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Sadatoshi Sakuma

Research Profile

Chemicals & Drugs

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Mouse
Rats

Anatomy

Physiology

Cell Movement

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Publications

TOP 3
Hideki Yamamoto; Hisako Muramatsu; Takashi Nakanishi; Yukikazu Natori; Sadatoshi Sakuma; Naoki Ishiguro; Takashi Muramatsu
Midkine as a molecular target: comparison of effects of chondroitin sulfate E and siRNA.
Mitsuru Horiba; Kenji Kadomatsu; Kenji Yasui; Jong-Kook Lee; Hiroharu Takenaka; Arihiro Sumida; Kaichiro Kamiya; Sen Chen; Sadatoshi Sakuma; Takashi Muramatsu; Itsuo Kodama
Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction.
Kazuhiko Inoh; Hisako Muramatsu; Shuhei Torii; Shinya Ikematsu; Munehiro Oda; Hideshi Kumai; Sadatoshi Sakuma; Tatsuya Inui; Terutoshi Kimura; Takashi Muramatsu
Doxorubicin-conjugated anti-midkine monoclonal antibody as a potential anti-tumor drug.

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All Publications

2006: Hideki Yamamoto; Hisako Muramatsu; Takashi Nakanishi; Yukikazu Natori; Sadatoshi Sakuma; Naoki Ishiguro; Takashi Muramatsu
Midkine as a molecular target: comparison of effects of chondroitin sulfate E and siRNA.
Biochemical and biophysical research communications 2006;351(4):915-9.
2006: Mitsuru Horiba; Kenji Kadomatsu; Kenji Yasui; Jong-Kook Lee; Hiroharu Takenaka; Arihiro Sumida; Kaichiro Kamiya; Sen Chen; Sadatoshi Sakuma; Takashi Muramatsu; Itsuo Kodama
Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction.
Circulation 2006;114(16):1713-20.
2006: Kazuhiko Inoh; Hisako Muramatsu; Shuhei Torii; Shinya Ikematsu; Munehiro Oda; Hideshi Kumai; Sadatoshi Sakuma; Tatsuya Inui; Terutoshi Kimura; Takashi Muramatsu
Doxorubicin-conjugated anti-midkine monoclonal antibody as a potential anti-tumor drug.
Japanese journal of clinical oncology 2006;36(4):207-11.
2004: Hisako Muramatsu; Peng Zou; Hiromichi Suzuki; Yoshihiro Oda; Guo-Yun Chen; Nahoko Sakaguchi; Sadatoshi Sakuma; Nobuaki Maeda; Masaharu Noda; Yoshikazu Takada; Takashi Muramatsu
alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor.
Journal of cell science 2004;117(Pt 22):5405-15.
2003: Shinya Ikematsu; Kohji Okamoto; Yoshihiro Yoshida; Munehiro Oda; Hitomi Sugano-Nagano; Kinya Ashida; Hideshi Kumai; Kenji Kadomatsu; Hisako Muramatsu; Sadatoshi Sakuma
High levels of urinary midkine in various cancer patients.
Biochemical and biophysical research communications 2003;306(2):329-32.
2003: Shinya Ikematsu; A Nakagawara; Y Nakamura; Sadatoshi Sakuma; K Wakai; Takashi Muramatsu; Kenji Kadomatsu
Correlation of elevated level of blood midkine with poor prognostic factors of human neuroblastomas.
British journal of cancer 2003;88(10):1522-6.
2003: Nahoko Sakaguchi; Hisako Muramatsu; Keiko Ichihara-Tanaka; Nobuaki Maeda; Masaharu Noda; Tokuo Yamamoto; Makoto Michikawa; Shinya Ikematsu; Sadatoshi Sakuma; Takashi Muramatsu
Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons.
Neuroscience research 2003;45(2):219-24.
2003: Peng Zou; Kun Zou; Hisako Muramatsu; Keiko Ichihara-Tanaka; Osami Habuchi; Shiori Ohtake; Shinya Ikematsu; Sadatoshi Sakuma; Takashi Muramatsu
Glycosaminoglycan structures required for strong binding to midkine, a heparin-binding growth factor.
Glycobiology 2003;13(1):35-42.
2001: Nobuyuki Kurosawa; Guo-Yun Chen; Kenji Kadomatsu; Shinya Ikematsu; Sadatoshi Sakuma; Takashi Muramatsu
Glypican-2 binds to midkine: the role of glypican-2 in neuronal cell adhesion and neurite outgrowth.
Glycoconjugate journal 2001;18(6):499-507.
2001: M Qi; Shinya Ikematsu; Nobuaki Maeda; Keiko Ichihara-Tanaka; Sadatoshi Sakuma; Masaharu Noda; Takashi Muramatsu; Kenji Kadomatsu
Haptotactic migration induced by midkine. Involvement of protein-tyrosine phosphatase zeta. Mitogen-activated protein kinase, and phosphatidylinositol 3-kinase.
The Journal of biological chemistry 2001;276(19):15868-75.
2000: Shinya Ikematsu; A Yano; K Aridome; M Kikuchi; Hideshi Kumai; H Nagano; K Okamoto; M Oda; Sadatoshi Sakuma; T Aikou; Hisako Muramatsu; Kenji Kadomatsu; Takashi Muramatsu
Serum midkine levels are increased in patients with various types of carcinomas.
British journal of cancer 2000;83(6):701-6.
2000: Kun Zou; Hisako Muramatsu; Shinya Ikematsu; Sadatoshi Sakuma; Ragaa Salama; T Shinomura; K Kimata; Takashi Muramatsu
A heparin-binding growth factor, midkine, binds to a chondroitin sulfate proteoglycan, PG-M/versican.
European journal of biochemistry / FEBS 2000;267(13):4046-53.
2000: Hisako Muramatsu; Kun Zou; Nahoko Sakaguchi; Shinya Ikematsu; Sadatoshi Sakuma; Takashi Muramatsu
LDL receptor-related protein as a component of the midkine receptor.
Biochemical and biophysical research communications 2000;270(3):936-41.
2000: M Qi; Shinya Ikematsu; Keiko Ichihara-Tanaka; Sadatoshi Sakuma; Takashi Muramatsu; Kenji Kadomatsu
Midkine rescues Wilms' tumor cells from cisplatin-induced apoptosis: regulation of Bcl-2 expression by Midkine.
Journal of biochemistry 2000;127(2):269-77.
2000: Mitsuru Horiba; Kenji Kadomatsu; E Nakamura; Hisako Muramatsu; Shinya Ikematsu; Sadatoshi Sakuma; K Hayashi; Y Yuzawa; Seiichi Matsuo; M Kuzuya; Tadashi Kaname; M Hirai; Hidehiko Saito; Takashi Muramatsu
Neointima formation in a restenosis model is suppressed in midkine-deficient mice.
The Journal of clinical investigation 2000;105(4):489-95.
2000: Nobuyuki Kurosawa; Kenji Kadomatsu; Shinya Ikematsu; Sadatoshi Sakuma; Terutoshi Kimura; Takashi Muramatsu
Midkine binds specifically to sulfatide the role of sulfatide in cell attachment to midkine-coated surfaces.
European journal of biochemistry / FEBS 2000;267(2):344-51.