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Christine Biron

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M Pilar Gil; Yuka Kanno; Kwangsin Kim; Seung-Hwan Lee; John J O'Shea; Mickaël J-Y Ploquin; Xin Wang; Wendy T Watford; Christine A Biron
Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function.
Seung-Hwan Lee; Maria F Fragoso; Christine A Biron
Cutting edge: a novel mechanism bridging innate and adaptive immunity: IL-12 induction of CD25 to form high-affinity IL-2 receptors on NK cells.
Christine A Biron
Yet another role for natural killer cells: cytotoxicity in immune regulation and viral persistence.

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2012: M Pilar Gil; Yuka Kanno; Kwangsin Kim; Seung-Hwan Lee; John J O'Shea; Mickaël J-Y Ploquin; Xin Wang; Wendy T Watford; Christine A Biron
Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function.
Blood 2012;120(18):3718-28.
2012: Seung-Hwan Lee; Maria F Fragoso; Christine A Biron
Cutting edge: a novel mechanism bridging innate and adaptive immunity: IL-12 induction of CD25 to form high-affinity IL-2 receptors on NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(6):2712-6.
2012: Christine A Biron
Yet another role for natural killer cells: cytotoxicity in immune regulation and viral persistence.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(6):1814-5.
2011: Christine A Biron; Charles M Rice
Innate immunity: trolling, responding and protecting against viral infections.
Current opinion in virology 2011;1(6):443-6.
2011: Ethan A Mack; Delia A Demers; Lara E Kallal; Christine A Biron
Type 1 interferon induction of natural killer cell gamma interferon production for defense during lymphocytic choriomeningitis virus infection.
mBio 2011;2(4):.
2010: Christine A Biron
More things in heaven and earth: defining innate and adaptive immunity.
Nature immunology 2010;11(12):1080-2.
2010: Christine A Biron
Expansion, maintenance, and memory in NK and T cells during viral infections: responding to pressures for defense and regulation.
PLoS pathogens 2010;6(3):e1000816.
2010: Takuya Miyagi; Seung-Hwan Lee; Christine A Biron
Intracellular staining for analysis of the expression and phosphorylation of signal transducers and activators of transcription (STATs) in NK cells.
Methods in molecular biology (Clifton, N.J.) 2010;612():159-75.
2009: Seung-Hwan Lee; Kwang-Sin Kim; Nassima Fodil-Cornu; Silvia M Vidal; Christine A Biron
Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection.
The Journal of experimental medicine 2009;206(10):2235-51.
2007: Takuya Miyagi; M Pilar Gil; Xin Wang; Jennifer Louten; Wen-Ming Chu; Christine A Biron
High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells.
The Journal of experimental medicine 2007;204(10):2383-96.
2007: Stanimir Ivanov; Ana-Maria Dragoi; Xin Wang; Corrado Dallacosta; Jennifer Louten; Giovanna Musco; Giovanni Sitia; George S Yap; Yinsheng Wan; Christine A Biron; Marco E Bianchi; Haichao Wang; Wen-Ming Chu
A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA.
Blood 2007;110(6):1970-81.
2007: Nikhat Contractor; Jennifer Louten; Leesun Kim; Christine A Biron; Brian L Kelsall
Cutting edge: Peyer's patch plasmacytoid dendritic cells (pDCs) produce low levels of type I interferons: possible role for IL-10, TGFbeta, and prostaglandin E2 in conditioning a unique mucosal pDC phenotype.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):2690-4.
2007: Seung-Hwan Lee; Takuya Miyagi; Christine A Biron
Keeping NK cells in highly regulated antiviral warfare.
Trends in immunology 2007;28(6):252-9.
2007: Katherine Ryman; Christina L Gardner; Kathryn C Meier; Christine A Biron; Robert E Johnston; William B Klimstra
Early restriction of alphavirus replication and dissemination contributes to age-dependent attenuation of systemic hyperinflammatory disease.
The Journal of general virology 2007;88(Pt 2):518-29.
2006: David Allman; Marc Dalod; Carine Asselin-Paturel; Thomas Delale; Scott H Robbins; Giorgio Trinchieri; Christine A Biron; Philippe Kastner; Susan Chan
Ikaros is required for plasmacytoid dendritic cell differentiation.
Blood 2006;108(13):4025-34.
2006: Jennifer Louten; Nico van Rooijen; Christine A Biron
Type 1 IFN deficiency in the absence of normal splenic architecture during lymphocytic choriomeningitis virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):3266-72.
2006: Hanna Sjölin; Scott H Robbins; Gilles Bessou; Asa S Hidmark; Elena Tomasello; Maria Johansson; Håkan Hall; Férose Charifi; Gunilla B Karlsson Hedestam; Christine A Biron; Klas Kärre; Petter Höglund; Eric Vivier; Marc Dalod
DAP12 signaling regulates plasmacytoid dendritic cell homeostasis and down-modulates their function during viral infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):2908-16.
2006: DeRen Huang; Fu-Dong Shi; Steffen Jung; Gary C Pien; Jintang Wang; Thais P Salazar-Mather; Toby T He; Jennifer T Weaver; Hans-Gustaf Ljunggren; Christine A Biron; Dan R Littman; Richard M Ransohoff
The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(7):896-905.
2006: M Pilar Gil; Rachelle Salomon; Jennifer Louten; Christine A Biron
Modulation of STAT1 protein levels: a mechanism shaping CD8 T-cell responses in vivo.
Blood 2006;107(3):987-93.
2005: Thomas Delale; André Paquin; Carine Asselin-Paturel; Marc Dalod; Géraldine Brizard; Elizabeth E M Bates; Philippe Kastner; Susan Chan; Shizuo Akira; Alain P Vicari; Christine A Biron; Giorgio Trinchieri; Francine Brière
MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6723-32.
2005: Massimo Morra; Robert A Barrington; Ana C Abadia-Molina; Susumo Okamoto; Aimee Julien; Charles Gullo; Anuj Kalsy; Matthew J Edwards; Gang Chen; Rosanne Spolski; Warren J Leonard; Brigitte T Huber; Persephone Borrow; Christine A Biron; Abhay R Satoskar; Michael C Carroll; Cox Terhorst
Defective B cell responses in the absence of SH2D1A.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(13):4819-23.
2005: Kirsten L Hokeness; William Kuziel; Christine A Biron; Thais P Salazar-Mather
Monocyte chemoattractant protein-1 and CCR2 interactions are required for IFN-alpha/beta-induced inflammatory responses and antiviral defense in liver.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1549-56.
2003: Natalya V Serbina; Thais P Salazar-Mather; Christine A Biron; William Kuziel; Eric G Pamer
TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection.
Immunity 2003;19(1):59-70.
2003: Marc Dalod; Tanya Hamilton; Rachelle Salomon; Thais P Salazar-Mather; Stanley C Henry; John D Hamilton; Christine A Biron
Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha/beta.
The Journal of experimental medicine 2003;197(7):885-98.
2003: Joan E Durbin; Lesley A Doughty; Ken Nguyen; Michael Caligiuri; Jeff Van Deusen; Christine A Biron
The role of STAT1 in viral sensitization to LPS.
Journal of endotoxin research 2003;9(5):313-6.
2002: Gary C Pien; Khuong B Nguyen; Lene Malmgaard; Abhay R Satoskar; Christine A Biron
A unique mechanism for innate cytokine promotion of T cell responses to viral infections.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5827-37.
2002: Khuong B Nguyen; Thais P Salazar-Mather; Marc Dalod; Jeffrey B Van Deusen; Xiao-Qing Wei; Foo Y Liew; Michael A Caligiuri; Joan E Durbin; Christine A Biron
Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4279-87.
2002: Khuong B Nguyen; Wendy T Watford; Rachelle Salomon; Sigrun Hofmann; Gary C Pien; Akio Morinobu; Massimo Gadina; John O'Shea; Christine A Biron
Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection.
Science (New York, N.Y.) 2002;297(5589):2063-6.
2002: Thais P Salazar-Mather; Casey A Lewis; Christine A Biron
Type I interferons regulate inflammatory cell trafficking and macrophage inflammatory protein 1alpha delivery to the liver.
The Journal of clinical investigation 2002;110(3):321-30.
2002: Lene Malmgaard; Thais P Salazar-Mather; Casey A Lewis; Christine A Biron
Promotion of alpha/beta interferon induction during in vivo viral infection through alpha/beta interferon receptor/STAT1 system-dependent and -independent pathways.
Journal of virology 2002;76(9):4520-5.
2002: Scott H Robbins; Khuong B Nguyen; Nobuaki Takahashi; Toshifumi Mikayama; Christine A Biron; Laurent Brossay
Cutting edge: inhibitory functions of the killer cell lectin-like receptor G1 molecule during the activation of mouse NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2585-9.
2002: Marc Dalod; Thais P Salazar-Mather; Lene Malmgaard; Casey Lewis; Carine Asselin-Paturel; Francine Brière; Giorgio Trinchieri; Christine A Biron
Interferon alpha/beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivo.
The Journal of experimental medicine 2002;195(4):517-28.
2002: Christine A Biron; Khuong B Nguyen; Gary C Pien
Innate immune responses to LCMV infections: natural killer cells and cytokines.
Current topics in microbiology and immunology 2002;263():7-27.
2001: Carine Asselin-Paturel; A Boonstra; Marc Dalod; Isabelle Durand; N Yessaad; Colette Dezutter-Dambuyant; Alain P Vicari; Anne O'Garra; Christine A Biron; Francine Brière; Giorgio Trinchieri
Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology.
Nature immunology 2001;2(12):1144-50.
2001: HC Su; Khuong B Nguyen; Thais P Salazar-Mather; MC Ruzek; Marc Dalod; Christine A Biron
NK cell functions restrain T cell responses during viral infections.
European journal of immunology 2001;31(10):3048-55.
2001: Christine A Biron
Interferons alpha and beta as immune regulators--a new look.
Immunity 2001;14(6):661-4.
2001: Carl Wu; Khuong B Nguyen; Gary C Pien; Ninghai Wang; Charles Gullo; Duncan Howie; M R Sosa; M J Edwards; Persephone Borrow; Abhay R Satoskar; Arlene H Sharpe; Christine A Biron; Cox Terhorst
SAP controls T cell responses to virus and terminal differentiation of TH2 cells.
Nature immunology 2001;2(5):410-4.
2001: Lesley A Doughty; K Nguyen; Joan E Durbin; Christine A Biron
A role for IFN-alpha beta in virus infection-induced sensitization to endotoxin.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2658-64.
2000: J Sayós; Khuong B Nguyen; Carl Wu; Susan E Stepp; Duncan Howie; John Schatzle; Vinay Kumar; Christine A Biron; Cox Terhorst
Potential pathways for regulation of NK and T cell responses: differential X-linked lymphoproliferative syndrome gene product SAP interactions with SLAM and 2B4.
International immunology 2000;12(12):1749-57.
2000: Gary C Pien; Abhay R Satoskar; K Takeda; S Akira; Christine A Biron
Cutting edge: selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infection.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):4787-91.
2000: Khuong B Nguyen; LP Cousens; Lesley A Doughty; Gary C Pien; Joan E Durbin; Christine A Biron
Interferon alpha/beta-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox.
Nature immunology 2000;1(1):70-6.
2000: Thais P Salazar-Mather; Thomas Hamilton; Christine A Biron
A chemokine-to-cytokine-to-chemokine cascade critical in antiviral defense.
The Journal of clinical investigation 2000;105(7):985-93.
2000: Katherine Ryman; William B Klimstra; Khuong B Nguyen; Christine A Biron; Robert E Johnston
Alpha/beta interferon protects adult mice from fatal Sindbis virus infection and is an important determinant of cell and tissue tropism.
Journal of virology 2000;74(7):3366-78.
2000: Gregory A Taylor; Carmen M Collazo; George S Yap; K Nguyen; T A Gregorio; L S Taylor; B Eagleson; L Secrest; Eileen Southon; S W Reid; Lino Tessarollo; M Bray; Daniel W McVicar; Kristin L Komschlies; Howard A Young; Christine A Biron; Alan Sher; George Vande Woude
Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):751-5.
2000: Gary C Pien; Christine A Biron
Compartmental differences in NK cell responsiveness to IL-12 during lymphocytic choriomeningitis virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):994-1001.
1999: William B Klimstra; Katherine Ryman; Kristen A Bernard; Khuong B Nguyen; Christine A Biron; Robert E Johnston
Infection of neonatal mice with sindbis virus results in a systemic inflammatory response syndrome.
Journal of virology 1999;73(12):10387-98.
1999: Laura K Hanson; Jacquelyn S Slater; Zaruhi Karabekian; HW Virgin; Christine A Biron; MC Ruzek; Nico van Rooijen; Richard P Ciavarra; Richard M Stenberg; Ann E Campbell
Replication of murine cytomegalovirus in differentiated macrophages as a determinant of viral pathogenesis.
Journal of virology 1999;73(7):5970-80.
1999: J She; MC Ruzek; P Velupillai; I de Aos; Baoping Wang; Donald A Harn; J Sancho; Christine A Biron; Cox Terhorst
Generation of antigen-specific cytotoxic T lymphocytes and regulation of cytokine production takes place in the absence of CD3zeta.
International immunology 1999;11(5):845-57.
1999: Khuong B Nguyen; Christine A Biron
Synergism for cytokine-mediated disease during concurrent endotoxin and viral challenges: roles for NK and T cell IFN-gamma production.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(9):5238-46.
1999: LP Cousens; R Peterson; S Hsu; A Dorner; John D Altman; Rafi Ahmed; Christine A Biron
Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection.
The Journal of experimental medicine 1999;189(8):1315-28.
1999: MC Ruzek; B D Pearce; Andrew H Miller; Christine A Biron
Endogenous glucocorticoids protect against cytokine-mediated lethality during viral infection.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3527-33.
1999: Christine A Biron; Khuong B Nguyen; Gary C Pien; LP Cousens; Thais P Salazar-Mather
Natural killer cells in antiviral defense: function and regulation by innate cytokines.
Annual review of immunology 1999;17():189-220.
1998: HC Su; LP Cousens; Loren D Fast; Mark K Slifka; RD Bungiro; Rafi Ahmed; Christine A Biron
CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):5007-17.
1998: Thais P Salazar-Mather; JS Orange; Christine A Biron
Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1alpha (MIP-1alpha)-dependent pathways.
The Journal of experimental medicine 1998;187(1):1-14.
1998: Christine A Biron; LP Cousens; MC Ruzek; HC Su; Thais P Salazar-Mather
Early cytokine responses to viral infections and their roles in shaping endogenous cellular immunity.
Advances in experimental medicine and biology 1998;452():143-9.
1997: JS Orange; Thais P Salazar-Mather; S M Opal; Christine A Biron
Mechanisms for virus-induced liver disease: tumor necrosis factor-mediated pathology independent of natural killer and T cells during murine cytomegalovirus infection.
Journal of virology 1997;71(12):9248-58.
1997: MC Ruzek; Andrew H Miller; S M Opal; B D Pearce; Christine A Biron
Characterization of early cytokine responses and an interleukin (IL)-6-dependent pathway of endogenous glucocorticoid induction during murine cytomegalovirus infection.
The Journal of experimental medicine 1997;185(7):1185-92.
1997: LP Cousens; JS Orange; HC Su; Christine A Biron
Interferon-alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):634-9.
1996: Thais P Salazar-Mather; R Ishikawa; Christine A Biron
NK cell trafficking and cytokine expression in splenic compartments after IFN induction and viral infection.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(7):3054-64.
1996: J S Orange; Christine A Biron
Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(12):4746-56.
1996: J S Orange; Christine A Biron
An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(3):1138-42.
1995: LP Cousens; J S Orange; Christine A Biron
Endogenous IL-2 contributes to T cell expansion and IFN-gamma production during lymphocytic choriomeningitis virus infection.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(12):5690-9.
1995: J S Orange; Baoping Wang; Cox Terhorst; Christine A Biron
Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration.
The Journal of experimental medicine 1995;182(4):1045-56.
1995: Christine A Biron; J S Orange
IL12 in acute viral infectious disease.
Research in immunology 1995;146(7-8):590-600.
1995: J S Orange; Thais P Salazar-Mather; S M Opal; Robert L Spencer; Andrew H Miller; Bruce McEwen; Christine A Biron
Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids.
The Journal of experimental medicine 1995;181(3):901-14.
1994: HC Su; J S Orange; L D Fast; A T Chan; Stephen J Simpson; Cox Terhorst; Christine A Biron
IL-2-dependent NK cell responses discovered in virus-infected beta 2-microglobulin-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5674-81.
1994: J S Orange; Stanley Wolf; Christine A Biron
Effects of IL-12 on the response and susceptibility to experimental viral infections.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(3):1253-64.
1993: HC Su; R Ishikawa; Christine A Biron
Transforming growth factor-beta expression and natural killer cell responses during virus infection of normal, nude, and SCID mice.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(9):4874-90.
1993: R Ishikawa; Christine A Biron
IFN induction and associated changes in splenic leukocyte distribution.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(9):3713-27.
1991: HC Su; Kimberly A Leite-Morris; L Braun; Christine A Biron
A role for transforming growth factor-beta 1 in regulating natural killer cell and T lymphocyte proliferative responses during acute infection with lymphocytic choriomeningitis virus.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(8):2717-27.
1991: M T Kasaian; Kimberly A Leite-Morris; Christine A Biron
The role of CD4+ cells in sustaining lymphocyte proliferation during lymphocytic choriomeningitis virus infection.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(6):1955-63.
1990: M T Kasaian; Christine A Biron
Cyclosporin A inhibition of interleukin 2 gene expression, but not natural killer cell proliferation, after interferon induction in vivo.
The Journal of experimental medicine 1990;171(3):745-62.
1990: M T Kasaian; Christine A Biron
Effects of cyclosporin A on IL-2 production and lymphocyte proliferation during infection of mice with lymphocytic choriomeningitis virus.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(1):299-306.
1990: Christine A Biron; H A Young; M T Kasaian
Interleukin 2-induced proliferation of murine natural killer cells in vivo.
The Journal of experimental medicine 1990;171(1):173-88.
1989: M T Kasaian; Christine A Biron
The activation of IL-2 transcription in L3T4+ and Lyt-2+ lymphocytes during virus infection in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(4):1287-92.