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Azucena Salas

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Nathan S Astrof; Azucena Salas; Motomu Shimaoka; JianFeng Chen; Timothy A Springer
Importance of force linkage in mechanochemistry of adhesion receptors.
WEI YANG; Christopher V Carman; Minsoo Kim; Azucena Salas; Motomu Shimaoka; Timothy A Springer
A small molecule agonist of an integrin, alphaLbeta2.
Lili Huang; Motomu Shimaoka; Isaac J Rondon; Illa Roy; Qing Chang; Melody Po; Daniel T Dransfield; Robert C Ladner; Albert S B Edge; Azucena Salas; Clive R Wood; Timothy A Springer; Edward H Cohen
Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1.

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All Publications

2006: Nathan S Astrof; Azucena Salas; Motomu Shimaoka; JianFeng Chen; Timothy A Springer
Importance of force linkage in mechanochemistry of adhesion receptors.
Biochemistry 2006;45(50):15020-8.
2006: WEI YANG; Christopher V Carman; Minsoo Kim; Azucena Salas; Motomu Shimaoka; Timothy A Springer
A small molecule agonist of an integrin, alphaLbeta2.
The Journal of biological chemistry 2006;281(49):37904-12.
2006: Lili Huang; Motomu Shimaoka; Isaac J Rondon; Illa Roy; Qing Chang; Melody Po; Daniel T Dransfield; Robert C Ladner; Albert S B Edge; Azucena Salas; Clive R Wood; Timothy A Springer; Edward H Cohen
Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1.
Journal of leukocyte biology 2006;80(4):905-14.
2006: Motomu Shimaoka; Minsoo Kim; Edward H Cohen; WEI YANG; Nathan S Astrof; Dan Peer; Azucena Salas; Audrey Ferrand; Timothy A Springer
AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(38):13991-6.
2006: Azucena Salas; Motomu Shimaoka; Uyen T Phan; Minsoo Kim; Timothy A Springer
Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity state.
The Journal of biological chemistry 2006;281(16):10876-82.
2004: Minsoo Kim; Christopher V Carman; WEI YANG; Azucena Salas; Timothy A Springer
The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2.
The Journal of cell biology 2004;167(6):1241-53.
2004: Chafen Lu; Motomu Shimaoka; Azucena Salas; Timothy A Springer
The binding sites for competitive antagonistic, allosteric antagonistic, and agonistic antibodies to the I domain of integrin LFA-1.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3972-8.
2004: Azucena Salas; Motomu Shimaoka; Avi N Kogan; Charlotte Harwood; Ulrich H von Andrian; Timothy A Springer
Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction.
Immunity 2004;20(4):393-406.
2004: WEI YANG; Motomu Shimaoka; Azucena Salas; Junichi Takagi; Timothy A Springer
Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):2906-11.
2003: Christopher V Carman; Chang-Duk Jun; Azucena Salas; Timothy A Springer
Endothelial cells proactively form microvilli-like membrane projections upon intercellular adhesion molecule 1 engagement of leukocyte LFA-1.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6135-44.
2003: JianFeng Chen; Azucena Salas; Timothy A Springer
Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster.
Nature structural biology 2003;10(12):995-1001.
2003: Motomu Shimaoka; Azucena Salas; WEI YANG; Gabriele Weitz-Schmidt; Timothy A Springer
Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other.
Immunity 2003;19(3):391-402.
2002: Azucena Salas; Motomu Shimaoka; Shuqi Chen; Christopher V Carman; Timothy A Springer
Transition from rolling to firm adhesion is regulated by the conformation of the I domain of the integrin lymphocyte function-associated antigen-1.
The Journal of biological chemistry 2002;277(52):50255-62.
2002: Motomu Shimaoka; Chafen Lu; Azucena Salas; Tsan Xiao; Junichi Takagi; Timothy A Springer
Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16737-41.
2001: M de Château; Selby Chen; Azucena Salas; Timothy A Springer
Kinetic and mechanical basis of rolling through an integrin and novel Ca2+-dependent rolling and Mg2+-dependent firm adhesion modalities for the alpha 4 beta 7-MAdCAM-1 interaction.
Biochemistry 2001;40(46):13972-9.