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Michael Birrer

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Benjamin Frederick Ganzfried; Benjamin Haibe-Kains; Curtis Huttenhower; Ina Jazic; Giovanni Parmigiani; Markus Riester; Thomas Risch; Svitlana Tyekucheva; Mahnaz Ahmadifar; Michael J Birrer; Xin Victoria Wang; Levi Waldron
curatedOvarianData: clinically annotated data for the ovarian cancer transcriptome.
Hua Li; Tianyu Li; Margarita Sánchez-Beato; Vinod Vathipadiekal; Hong Wu; Michael J Birrer; Qi Cai; Zachary C Dobbin; Xiang Hua; Charles N Landen; Rugang Zhang
SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK.
Kathryn Alsop; Michael J Birrer; David Bowtell; Anna deFazio; Alexander Dobrovic; Catherine Emmanuel; Sian Fereday; Stephen Fox; Michael Friedlander; Joshy George; Cliff Meldrum; Colin Stewart; Penelope M Webb; Gillian Mitchell
BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group.

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2013: Benjamin Frederick Ganzfried; Benjamin Haibe-Kains; Curtis Huttenhower; Ina Jazic; Giovanni Parmigiani; Markus Riester; Thomas Risch; Svitlana Tyekucheva; Mahnaz Ahmadifar; Michael J Birrer; Xin Victoria Wang; Levi Waldron
curatedOvarianData: clinically annotated data for the ovarian cancer transcriptome.
Database : the journal of biological databases and curation 2013;2013():bat013.
2012: Hua Li; Tianyu Li; Margarita Sánchez-Beato; Vinod Vathipadiekal; Hong Wu; Michael J Birrer; Qi Cai; Zachary C Dobbin; Xiang Hua; Charles N Landen; Rugang Zhang
SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK.
Molecular cancer research : MCR 2012;10(11):1462-72.
2012: Kathryn Alsop; Michael J Birrer; David Bowtell; Anna deFazio; Alexander Dobrovic; Catherine Emmanuel; Sian Fereday; Stephen Fox; Michael Friedlander; Joshy George; Cliff Meldrum; Colin Stewart; Penelope M Webb; Gillian Mitchell
BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(21):2654-63.
2012: Diane C Bodurka; Robert L Coleman; Michael T Deavers; Robert E Emerson; Rebecca Baergen; Behnaz Behmaram; Michael J Birrer; Karen H Lu; Anais Malpica; Robert Ozols; Golnar Rasty; Anil K Sood; Margaret Steinhoff; Charlotte C Sun; Chunqiao Tian; David M Gershenson
Reclassification of serous ovarian carcinoma by a 2-tier system: a Gynecologic Oncology Group Study.
Cancer 2012;118(12):3087-94.
2012: Hua Li; Marie E Maradeo; Michael Slifker; Peter J Tummino; Vinod Vathipadiekal; Michael J Birrer; Benjamin G Bitler; Paul Cairns; Caretha L Creasy; Rugang Zhang
ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches.
Cancer prevention research (Philadelphia, Pa.) 2012;5(3):484-91.
2012: Geetika Sethi; Vinod Vathipadiekal; Hong Zhang; Yan Zhou; Michael J Birrer; Margret B Einarson; Sumedha Gunewardena; Harsh B Pathak; Andrew K Godwin
An RNA interference lethality screen of the human druggable genome to identify molecular vulnerabilities in epithelial ovarian cancer.
PloS one 2012;7(10):e47086.
2012: Susannah Kassler; Howard Donninger; Michael J Birrer; Geoffrey J Clark
RASSF1A and the Taxol Response in Ovarian Cancer.
Molecular biology international 2012;2012():263267.
2012: David A Engler; David M Gershenson; Joe W Gray; Jenny Gross; Whitfield B Growdon; Sumeet Gupta; Beth Y Karlan; Wen-Lin Kuo; Serena F Allred; Michael J Birrer; Michael T Deavers; Ronny I Drapkin; Mai Nitta; Sandra Orsulic; Bo R Rueda; Petra A Sergent; Gayatry Mohapatra
Genome wide DNA copy number analysis of serous type ovarian carcinomas identifies genetic markers predictive of clinical outcome.
PloS one 2012;7(2):e30996.
2012: Vinod Vathipadiekal; Peter V Hauschka; Samuel C Mok; Laurent Ozbun; Deepa Saxena; Michael J Birrer
Identification of a potential ovarian cancer stem cell gene expression profile from advanced stage papillary serous ovarian cancer.
PloS one 2012;7(1):e29079.
2011: Michelle F Maritz; Pauline J van der Watt; Nina Holderness; Michael J Birrer; Virna D Leaner
Inhibition of AP-1 suppresses cervical cancer cell proliferation and is associated with p21 expression.
Biological chemistry 2011;392(5):439-48.
2011: John Farley; Leia M Smith; Kathleen M Darcy; Mark F Brady; Jeffrey Bell; William McGuire; Michael J Birrer
Nuclear P27 expression in benign, borderline (LMP) and invasive tumors of the ovary and its association with prognosis: a gynecologic oncology group study.
Gynecologic oncology 2011;121(2):395-401.
2011: Junko Kikuchi; Ichiro Kinoshita; Yasushi Shimizu; Eiki Kikuchi; Kayoko Takeda; Hiroyuki Aburatani; Satoshi Oizumi; Jun Konishi; Kichizo Kaga; Yoshihiro Matsuno; Michael J Birrer; Masaharu Nishimura; Hirotoshi Dosaka-Akita
Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2011;72(2):229-37.
2011: Michael S Anglesio; Joshy George; Hagen Kulbe; Michael Friedlander; Danny Rischin; Charlotte Lemech; Jeremy Power; Jermaine Coward; Prue A Cowin; Colin M House; Probir Chakravarty; Kylie L Gorringe; Ian G Campbell; Aikou Okamoto; Michael J Birrer; David G Huntsman; Anna de Fazio; Steve Kalloger; Frances Balkwill; C Blake Gilks; David D L Bowtell
IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2538-48.
2011: Christopher K McCann; Gayatry Mohapatra; Jennifer L Proctor; Hana Sheikh; Vinod Vathipadiekal; Lawrence R Zukerberg; Michael J Birrer; Darrell R Borger; Michael D Curley; Igor Deyneko; Jeanne A Ferguson; Rosemary Foster; Anne M Friel; Whitfield B Growdon; Kashmira Kulkarni-Datar; John R Macdougall; Bo R Rueda
Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model.
PloS one 2011;6(11):e28077.
2010: Sue Ghosh; Lina Albitar; Richard G LeBaron; William R Welch; Goli Samimi; Michael J Birrer; Ross S Berkowitz; Samuel C Mok
Up-regulation of stromal versican expression in advanced stage serous ovarian cancer.
Gynecologic oncology 2010;119(1):114-20.
2010: Christina Annunziata; Helene Tuft Stavnes; Lilach Kleinberg; Aasmund Berner; Lidia F Hernandez; Michael J Birrer; Seth M Steinberg; Ben Davidson; Elise C Kohn
Nuclear factor kappaB transcription factors are coexpressed and convey a poor outcome in ovarian cancer.
Cancer 2010;116(13):3276-84.
2010: Lídia Hernandez; Sarah C Hsu; Ben Davidson; Michael J Birrer; Elise C Kohn; Christina M Annunziata
Activation of NF-kappaB signaling by inhibitor of NF-kappaB kinase beta increases aggressiveness of ovarian cancer.
Cancer research 2010;70(10):4005-14.
2010: Adam Clauss; Vivian Ng; Joyce Liu; Huiying Piao; Moises Russo; Natalie Vena; Qing Sheng; Michelle S Hirsch; Tomas Bonome; Ursula Matulonis; Azra H Ligon; Michael J Birrer; Ronny Drapkin
Overexpression of elafin in ovarian carcinoma is driven by genomic gains and activation of the nuclear factor kappaB pathway and is associated with poor overall survival.
Neoplasia (New York, N.Y.) 2010;12(2):161-72.
2010: Lucas Minig; Edward L Trimble; Michael J Birrer; Kelly Y Kim; Naoko Takebe; Jeffrey S Abrams
NIH and NCI support for development of novel therapeutics in gynecologic cancer: a user's guide.
Gynecologic oncology 2010;116(2):177-80.
2010: John H Farley; Chunqiao Tian; G Scott Rose; Carol L Brown; Michael J Birrer; John Risinger; J Tate Thigpen; Gini F Fleming; Holly H Gallion; G Larry Maxwell
Chemotherapy intensity and toxicity among black and white women with advanced and recurrent endometrial cancer: a Gynecologic Oncology Group Study.
Cancer 2010;116(2):355-61.
2009: Samuel C Mok; Tomas Bonome; Vinod Vathipadiekal; Aaron Bell; Michael E Johnson; Kwong-Kwok Wong; Dong-Choon Park; Ke Hao; Daniel K P Yip; Howard Donninger; Laurent Ozbun; Goli Samimi; John Brady; Mike Randonovich; Cynthia A Pise-Masison; J Carl Barrett; Wing H Wong; William R Welch; Ross S Berkowitz; Michael J Birrer
A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotein 2.
Cancer cell 2009;16(6):521-32.
2009: John H Farley; Chunqiao Tian; G Scott Rose; Carol L Brown; Michael J Birrer; G Larry Maxwell
Race does not impact outcome for advanced ovarian cancer patients treated with cisplatin/paclitaxel: an analysis of Gynecologic Oncology Group trials.
Cancer 2009;115(18):4210-7.
2009: Kathleen M Darcy; William E Brady; Jan K Blancato; Robert B Dickson; William J Hoskins; William P McGuire; Michael J Birrer
Prognostic relevance of c-MYC gene amplification and polysomy for chromosome 8 in suboptimally-resected, advanced stage epithelial ovarian cancers: a Gynecologic Oncology Group study.
Gynecologic oncology 2009;114(3):472-9.
2009: Xiao-Yang Wang; Abeba Demelash; Heungnam Kim; Sandra M Jensen-Taubman; El Habib Dakir; Laurent Ozbun; Michael J Birrer; R Ilona Linnoila
Matrilysin-1 mediates bronchiolization of alveoli, a potential premalignant change in lung cancer.
The American journal of pathology 2009;175(2):592-604.
2009: Joseph Kwong; Franky Leung Chan; Kwong-Kwok Wong; Michael J Birrer; Kyra M Archibald; Frances R Balkwill; Ross S Berkowitz; Samuel C Mok
Inflammatory cytokine tumor necrosis factor alpha confers precancerous phenotype in an organoid model of normal human ovarian surface epithelial cells.
Neoplasia (New York, N.Y.) 2009;11(6):529-41.
2009: Diego F Calvisi; Howard Donninger; Michele D Vos; Michael J Birrer; Laura Gordon; Virna Leaner; Geoffrey J Clark
NORE1A tumor suppressor candidate modulates p21CIP1 via p53.
Cancer research 2009;69(11):4629-37.
2009: Vladimir Nosov; Feng Su; Malaika Amneus; Michael J Birrer; Terry Robins; Jenny Kotlerman; Srinivasa Reddy; Robin Farias-Eisner
Validation of serum biomarkers for detection of early-stage ovarian cancer.
American journal of obstetrics and gynecology 2009;200(6):639.e1-5.
2009: John Farley; Sartoru Fuchiuji; Kathleen M Darcy; Chunqiao Tian; William J Hoskins; William P McGuire; Parviz Hanjani; David Warshal; Benjamin E Greer; Jerome Belinson; Michael J Birrer
Associations between ERBB2 amplification and progression-free survival and overall survival in advanced stage, suboptimally-resected epithelial ovarian cancers: a Gynecologic Oncology Group Study.
Gynecologic oncology 2009;113(3):341-7.
2009: Bo Wang; Levon M Khachigian; Luke Esau; Michael J Birrer; Xiaohang Zhao; M Iqbal Parker; Denver T Hendricks
A key role for early growth response-1 and nuclear factor-kappaB in mediating and maintaining GRO/CXCR2 proliferative signaling in esophageal cancer.
Molecular cancer research : MCR 2009;7(5):755-64.
2009: Sarvjeet Singh; Shilpa M Manda; Devanjan Sikder; Michael J Birrer; Beverly Rothermel; Daniel J Garry; Pradeep P.A. Mammen
Calcineurin activates cytoglobin transcription in hypoxic myocytes.
The Journal of biological chemistry 2009;284(16):10409-21.
2009: Pauline J van der Watt; Christopher P Maske; Denver T Hendricks; M Iqbal Parker; Lynette Denny; Dhirendra Govender; Michael J Birrer; Virna D Leaner
The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.
International journal of cancer. Journal international du cancer 2009;124(8):1829-40.
2009: Tony CHUNG; Tak-Hong Cheung; Ngar-Yee Huen; Katherine W Y Wong; Kwok-Wai Lo; So-Fan Yim; Nelson S S Siu; Yin-Mei Wong; Po-Ting Tsang; Man-Wah Pang; Mei-Yun Yu; Ka-Fei To; Samuel C Mok; Vivian W Wang; Chen Li; Albert Y K Cheung; Graeme Doran; Michael J Birrer; David I Smith; Yick Fu Wong
Dysregulated microRNAs and their predicted targets associated with endometrioid endometrial adenocarcinoma in Hong Kong women.
International journal of cancer. Journal international du cancer 2009;124(6):1358-65.
2009: John Farley; Michael J Birrer
Novel therapeutic targets.
Cancer treatment and research 2009;149():63-84.
2009: Virna D Leaner; Jeffrey F Chick; Howard Donninger; Ilona Linniola; Arnulfo Mendoza; Chand Khanna; Michael J Birrer
Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcoma.
The American journal of pathology 2009;174(1):265-75.
2008: Alexandra Mourad; Yvonne G Lin; Liz Y Han; Aparna A Kamat; Whitney A Spannuth; Rosemarie Schmandt; Diana Urbauer; Len A Pennacchio; Jan-Fang Cheng; Alpa M Nick; Michael T Deavers; Alexandra Mourad-Zeidan; Hua Wang; Peter Mueller; Marc E Lenburg; Joe Gray; Samuel Mok; Michael J Birrer; Gabriel Lopez-Berestein; Robert L Coleman; Menashe Bar-Eli; Anil K Sood
Dicer, Drosha, and outcomes in patients with ovarian cancer.
The New England journal of medicine 2008;359(25):2641-50.
2008: J Kikuchi; I Kinoshita; Y Shimizu; S Oizumi; M Nishimura; Michael J Birrer; H Dosaka-Akita
Simultaneous blockade of AP-1 and phosphatidylinositol 3-kinase pathway in non-small cell lung cancer cells.
British journal of cancer 2008;99(12):2013-9.
2008: Michael J Callahan; Zoltán Nagymányoki; Tomas Bonome; Michael E Johnson; Babak Litkouhi; Elizabeth H Sullivan; Michelle S Hirsch; Ursula Matulonis; Joyce Liu; Michael J Birrer; Ross S Berkowitz; Samuel C Mok
Increased HLA-DMB expression in the tumor epithelium is associated with increased CTL infiltration and improved prognosis in advanced-stage serous ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(23):7667-73.
2008: Michael S Anglesio; Jeremy M Arnold; joshy george; Anna V Tinker; Richard Tothill; Nic Waddell; Lisa Simms; Bianca Locandro; Sian Fereday; Nadia Traficante; Peter Russell; Raghwa Sharma; Michael J Birrer; Anna deFazio; Georgia Chenevix-Trench; David D L Bowtell
Mutation of ERBB2 provides a novel alternative mechanism for the ubiquitous activation of RAS-MAPK in ovarian serous low malignant potential tumors.
Molecular cancer research : MCR 2008;6(11):1678-90.
2008: Philip L Lorenzi; Jenny Llamas; Michele Gunsior; Laurent Ozbun; William C Reinhold; Sudhir Varma; Helen Ji; Hijoo Kim; Amy A Hutchinson; Elise C Kohn; Paul Goldsmith; Michael J Birrer; John N Weinstein
Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines.
Molecular cancer therapeutics 2008;7(10):3123-8.
2008: Dong Choon Park; Seung Geun Yeo; Mark R Wilson; Justin J Yerbury; Joseph Kwong; William R Welch; Yang-Kyu Choi; Michael J Birrer; Samuel C Mok; Kwong-Kwok Wong
Clusterin interacts with Paclitaxel and confer Paclitaxel resistance in ovarian cancer.
Neoplasia (New York, N.Y.) 2008;10(9):964-72.
2008: Anil K Sood; Michael J Birrer
Highlights from the 2008 Annual Meeting of the American Association for Cancer Research.
Gynecologic oncology 2008;110(1):5-6.
2008: Tomas Bonome; Douglas A Levine; Joanna Shih; Mike Randonovich; Cynthia A Pise-Masison; Faina Bogomolniy; Laurent Ozbun; John Brady; J Carl Barrett; Jeff Boyd; Michael J Birrer
A gene signature predicting for survival in suboptimally debulked patients with ovarian cancer.
Cancer research 2008;68(13):5478-86.
2008: Lin Zhang; Stefano Volinia; Tomas Bonome; George Adrian Calin; Joel Greshock; Nuo Yang; Chang-gong liu; Antonis Giannakakis; Pangiotis Alexiou; Kosei Hasegawa; Cameron N Johnstone; Molly S Megraw; Sarah Adams; Heini Lassus; Jia Huang; Sippy Kaur; Shun Liang; Praveen Sethupathy; Arto Leminen; Victor A Simossis; Raphael Sandaltzopoulos; Yoshio Naomoto; Dionyssios Katsaros; Phyllis A Gimotty; Angela DeMichele; Qihong Huang; Ralf Bützow; Anil K Rustgi; Barbara L Weber; Michael J Birrer; Artemis G Hatzigeorgiou; Carlo M Croce; George Coukos
Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(19):7004-9.
2008: John Farley; Laurent L Ozbun; Michael J Birrer
Genomic analysis of epithelial ovarian cancer.
Cell research 2008;18(5):538-48.
2008: Behrang Litkouhi; Babak Litkouhi; Evelyn Fleming; William R Welch; Ross S Berkowitz; Michael J Birrer; Samuel C Mok
Overexpression of CEACAM6 in borderline and invasive mucinous ovarian neoplasms.
Gynecologic oncology 2008;109(2):234-9.
2008: Y Shimizu; I Kinoshita; J Kikuchi; K Yamazaki; Masaharu Nishimura; Michael J Birrer; Hirotoshi Dosaka-Akita
Growth inhibition of non-small cell lung cancer cells by AP-1 blockade using a cJun dominant-negative mutant.
British journal of cancer 2008;98(5):915-22.
2008: Charles N Landen; Michael J Birrer; Anil K Sood
Early events in the pathogenesis of epithelial ovarian cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(6):995-1005.
2008: Enrique Zudaire; Natalia Cuesta; Vundavalli Murty; Karen Woodson; Lisa Adams; Nieves González; Alfredo Martínez; Gopeshwar Narayan; Ilan Kirsch; Wilbur Franklin; Fred Hirsch; Michael J Birrer; Frank Cuttitta
The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers.
The Journal of clinical investigation 2008;118(2):640-50.
2008: Carlos E Irarrazabal; Chester K Williams; Megan A Ely; Michael J Birrer; Arlyn Garcia-Perez; MAURICE BURG; Joan D Ferraris
Activator protein-1 contributes to high NaCl-induced increase in tonicity-responsive enhancer/osmotic response element-binding protein transactivating activity.
The Journal of biological chemistry 2008;283(5):2554-63.
2008: Shilpi Arora; Yipeng Wang; Zhenyu Jia; Saynur Vardar-Sengul; Ayla Munawar; Kutbuddin S Doctor; Michael J Birrer; Michael McClelland; Eileen Adamson; Dan Mercola
Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip.
Genome biology 2008;9(11):R166.
2008: Michael P Stany; Tomas Bonome; Fred Wamunyokoli; Kristen Zorn; Laurent Ozbun; Dong-Choon Park; Ke Hao; Jeff Boyd; Anil K Sood; David M Gershenson; Ross S Berkowitz; Samuel C Mok; Michael J Birrer
Classification of ovarian cancer: a genomic analysis.
Advances in experimental medicine and biology 2008;622():23-33.
2007: Nadia P C Allen; Howard Donninger; Michele D Vos; Kristin Eckfeld; Luke Hesson; L Gordon; Michael J Birrer; Farida Latif; Geoffrey J Clark
RASSF6 is a novel member of the RASSF family of tumor suppressors.
Oncogene 2007;26(42):6203-11.
2007: Catherine E Whibley; Kerry L McPhail; Robert A Keyzers; Michelle F Maritz; Virna D Leaner; Michael J Birrer; Michael T Davies-Coleman; Denver T Hendricks
Reactive oxygen species mediated apoptosis of esophageal cancer cells induced by marine triprenyl toluquinones and toluhydroquinones.
Molecular cancer therapeutics 2007;6(9):2535-43.
2007: Risto Kajanne; Päivi J Miettinen; Annika Mehlem; Suvi-Katri Leivonen; Michael J Birrer; Marco Foschi; Veli-Matti Kähäri; Sirpa Leppä
EGF-R regulates MMP function in fibroblasts through MAPK and AP-1 pathways.
Journal of cellular physiology 2007;212(2):489-97.
2007: David M Gershenson; Michael J Birrer
Time for action: a "sea change" in treatment strategies for rare types of epithelial ovarian cancer.
Gynecologic oncology 2007;106(1):1-3.
2007: Michael J Birrer; Michael E Johnson; Ke Hao; Kwong-Kwok Wong; Dong-Choon Park; Aaron Bell; William R Welch; Ross S Berkowitz; Samuel C Mok
Whole genome oligonucleotide-based array comparative genomic hybridization analysis identified fibroblast growth factor 1 as a prognostic marker for advanced-stage serous ovarian adenocarcinomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(16):2281-7.
2007: Yick Fu Wong; Tak-Hong Cheung; Kwok-Wai Lo; So-Fan Yim; N S S Siu; S C S Chan; T W F Ho; K W Y Wong; M Y Yu; Vivian W Wang; C Li; Ginger J Gardner; Tomas Bonome; W B Johnson; David I Smith; Tony CHUNG; Michael J Birrer
Identification of molecular markers and signaling pathway in endometrial cancer in Hong Kong Chinese women by genome-wide gene expression profiling.
Oncogene 2007;26(13):1971-82.
2007: Kongming Wu; Manran Liu; Anping Li; Howard Donninger; Mahadev Rao; Xuanmao Jiao; Michael P Lisanti; Ales Cvekl; Michael J Birrer; Richard G Pestell
Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth.
Molecular biology of the cell 2007;18(3):755-67.
2007: Chunhua Lu; Tomas Bonome; Yang Li; Aparna A Kamat; Liz Y Han; Rosemarie Schmandt; Robert L Coleman; David M Gershenson; Robert B Jaffe; Michael J Birrer; Anil K Sood
Gene alterations identified by expression profiling in tumor-associated endothelial cells from invasive ovarian carcinoma.
Cancer research 2007;67(4):1757-68.
2007: John Farley; Laurent L Ozbun; Goli Samimi; Michael J Birrer
Cell cycle and related protein.
Disease markers 2007;23(5-6):433-43.
2007: Goli Samimi; Laurent L Ozbun; Michael E Johnson; Samuel C Mok; Michael J Birrer
Biomarkers of mucinous tumors of the ovary.
Disease markers 2007;23(5-6):389-96.
2007: Samuel C Mok; Joseph Kwong; William R Welch; Goli Samimi; Laurent L Ozbun; Tomas Bonome; Michael J Birrer; Ross S Berkowitz; Kwong-Kwok Wong
Etiology and pathogenesis of epithelial ovarian cancer.
Disease markers 2007;23(5-6):367-76.
2007: Gary J Kelloff; Daniel C Sullivan; Houston Baker; Lawrence P Clarke; Robert Nordstrom; James L Tatum; Gary S Dorfman; Paula Jacobs; Christine D Berg; Martin G Pomper; Michael J Birrer; Margaret Tempero; Howard R Higley; Brenda Gumbs Petty; Caroline C Sigman; Carlo Maley; Prateek Sharma; Adam Wax; Gregory G Ginsberg; Andrew J Dannenberg; Ernest T Hawk; Edward M Messing; H Barton Grossman; Mukesh Harisinghani; Irving J Bigio; Donna Griebel; Donald E Henson; Carol J Fabian; Katherine Ferrara; Sergio Fantini; Mitchell D Schnall; Jo Anne Zujewski; Wendy Hayes; Eric A Klein; Angelo M DeMarzo; Iclal Ocak; Jeffrey A Ketterling; Clare Tempany; Faina Shtern; Howard L Parnes; Jorge Gomez; sudhir srivastava; Eva Szabo; Stephen Lam; Eric J Seibel; Pierre Massion; Geoffrey McLennan; Kevin Cleary; Robert Suh; Randall W Burt; Ruth M Pfeiffer; John M Hoffman; Hemant K Roy; Thomas D Wang; Paul J Limburg; Wafik S El-Deiry; Vali Papadimitrakopoulou; Walter N Hittelman; Calum MacAulay; Robert W Veltri; Diane Solomon; Jose Jeronimo; Rebecca Richards-Kortum; Karen A Johnson; Jaye L Viner; Steven P Stratton; Milind Rajadhyaksha; Atam Dhawan
Workshop on imaging science development for cancer prevention and preemption.
Cancer biomarkers : section A of Disease markers 2007;3(1):1-33.
2007: Samuel C Mok; Kevin M Elias; Kwong-Kwok Wong; Kae Ho; Tomas Bonome; Michael J Birrer
Biomarker discovery in epithelial ovarian cancer by genomic approaches.
Advances in cancer research 2007;96():1-22.
2006: John Farley; Michael J Birrer; Michaele C Christian
The future of phase II trials.
Gynecologic oncology 2006;103(2 Suppl 1):S20-2.
2006: John Farley; Robert C Bast; Michael J Birrer
Biomarkers and clinical trial design.
Gynecologic oncology 2006;103(2 Suppl 1):S3-5.
2006: Jane Fountain; Edward L Trimble; Michael J Birrer
Summary and discussion of session recommendations.
Gynecologic oncology 2006;103(2 Suppl 1):S23-5.
2006: Jan S Sunde; Howard Donninger; Kongming Wu; Michael E Johnson; Richard G Pestell; G Scott Rose; Samuel C Mok; John Brady; Tomas Bonome; Michael J Birrer
Expression profiling identifies altered expression of genes that contribute to the inhibition of transforming growth factor-beta signaling in ovarian cancer.
Cancer research 2006;66(17):8404-12.
2006: Michael J Birrer
Ovarian cancer: not a borderline issue!
Cancer biology & therapy 2006;5(7):786-7.
2006: Analisa Difeo; Goutham Narla; Jennifer Hirshfeld; Olga Camacho-Vanegas; Jyothsna Narla; Stephen L Rose; Tamara Kalir; Shen Yao; Alice Levine; Michael J Birrer; Tomas Bonome; Scott L Friedman; Richard E Buller; John A Martignetti
Roles of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(12):3730-9.
2006: Fred W Wamunyokoli; Tomas Bonome; Ji-Young Lee; Colleen M Feltmate; William R Welch; Michael F Radonovich; Cynthia A Pise-Masison; John Brady; Ke Hao; Ross S Berkowitz; Samuel Mok; Michael J Birrer
Expression profiling of mucinous tumors of the ovary identifies genes of clinicopathologic importance.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(3 Pt 1):690-700.
2006: Pirjo Nummela; Miao Yin; Mari Kielosto; Virna D Leaner; Michael J Birrer; Erkki Hölttä
Thymosin beta4 is a determinant of the transformed phenotype and invasiveness of S-adenosylmethionine decarboxylase-transfected fibroblasts.
Cancer research 2006;66(2):701-12.
2005: Tomas Bonome; Ji-Young Lee; Dong-Choon Park; Michael F Radonovich; Cynthia A Pise-Masison; John Brady; Ginger J Gardner; Ke Hao; Wing H Wong; J Carl Barrett; Karen H Lu; Anil K Sood; David M Gershenson; Samuel C Mok; Michael J Birrer
Expression profiling of serous low malignant potential, low-grade, and high-grade tumors of the ovary.
Cancer research 2005;65(22):10602-12.
2005: Hiroshi Tsuda; Yoichi M Ito; Yasuo Ohashi; Kwong-Kwok Wong; Yasunori Hashiguchi; William R Welch; Ross S Berkowitz; Michael J Birrer; Samuel C Mok
Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(19 Pt 1):6880-8.
2005: Kristin K Zorn; Tomas Bonome; Lisa Gangi; Gadisetti V R Chandramouli; Christopher S Awtrey; Ginger J Gardner; J Carl Barrett; Jeff Boyd; Michael J Birrer
Gene expression profiles of serous, endometrioid, and clear cell subtypes of ovarian and endometrial cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(18):6422-30.
2005: Amir A Jazaeri; Christopher S Awtrey; Gadisetti V R Chandramouli; Yao Eric Chuang; Javed Khan; Christos Sotiriou; Olga Aprelikova; Cindy J Yee; Kristin K Zorn; Michael J Birrer; J Carl Barrett; Jeff Boyd
Gene expression profiles associated with response to chemotherapy in epithelial ovarian cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6300-10.
2005: Motoo Katabami; Howard Donninger; Fumihiro Hommura; Virna D Leaner; Ichiro Kinoshita; Jeffrey F B Chick; Michael J Birrer
Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells.
The Journal of biological chemistry 2005;280(17):16728-38.
2005: Candice Elam; Luke Hesson; Michele D Vos; Kristin Eckfeld; Chad A Ellis; Aaron Bell; Dietmar Krex; Michael J Birrer; Farida Latif; Geoffrey J Clark
RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor suppressor potential.
Cancer research 2005;65(8):3117-25.
2005: Virna D Leaner; Howard Donninger; Chad A Ellis; Geoffrey J Clark; Michael J Birrer
p75-Ras-GRF1 is a c-Jun/AP-1 target protein: its up regulation results in increased Ras activity and is necessary for c-Jun-induced nonadherent growth of Rat1a cells.
Molecular and cellular biology 2005;25(8):3324-37.
2004: Hiroshi Tsuda; Michael J Birrer; Yoichi M Ito; Yasuo Ohashi; Ming Lin; Cheng Lee; Wing H Wong; Pulivarthi H Rao; Ching C Lau; Ross S Berkowitz; Kwong-Kwok Wong; Samuel C Mok
Identification of DNA copy number changes in microdissected serous ovarian cancer tissue using a cDNA microarray platform.
Cancer genetics and cytogenetics 2004;155(2):97-107.
2004: Howard Donninger; Tomas Bonome; Michael F Radonovich; Cynthia A Pise-Masison; John Brady; Joanna H Shih; J Carl Barrett; Michael J Birrer
Whole genome expression profiling of advance stage papillary serous ovarian cancer reveals activated pathways.
Oncogene 2004;23(49):8065-77.
2004: Kamaleldin E Elagib; Mang Xiao; Isa M Hussaini; Lorrie L Delehanty; Lisa A Palmer; Frederick K Racke; Michael J Birrer; Ganapath Shanmugasundaram; A MICHAEL MCDEVITT; Adam N Goldfarb
Jun blockade of erythropoiesis: role for repression of GATA-1 by HERP2.
Molecular and cellular biology 2004;24(17):7779-94.
2004: Mark E Sherman; Jules Berman; Michael J Birrer; Kathleen R Cho; Lora Hedrick Ellenson; Fred Gorstein; Jeffrey D Seidman
Current challenges and opportunities for research on borderline ovarian tumors.
Human pathology 2004;35(8):961-70.
2004: Mari Kielosto; Pirjo Nummela; Riikka Katainen; Virna D Leaner; Michael J Birrer; Erkki Hölttä
Reversible regulation of the transformed phenotype of ornithine decarboxylase- and ras-overexpressing cells by dominant-negative mutants of c-Jun.
Cancer research 2004;64(11):3772-9.
2004: Fumihiro Hommura; Motoo Katabami; Virna D Leaner; Howard Donninger; Takita F Sumter; Linda M. Resar; Michael J Birrer
HMG-I/Y is a c-Jun/activator protein-1 target gene and is necessary for c-Jun-induced anchorage-independent growth in Rat1a cells.
Molecular cancer research : MCR 2004;2(5):305-14.
2004: Xiaofeng Zhou; RICHARD JORDAN; Samuel Mok; Michael J Birrer; David T W Wong
DNA copy number abnormality of oral squamous cell carcinoma detected with cDNA array-based comparative genomic hybridization.
Cancer genetics and cytogenetics 2004;151(1):90-2.
2004: Mauricio Cuello; A O Coats; I Darko; Seth A Ettenberg; Ginger J Gardner; Marion M Nau; J Rebecca Liu; Michael J Birrer; Stan Lipkowitz
N-(4-hydroxyphenyl) retinamide (4HPR) enhances TRAIL-mediated apoptosis through enhancement of a mitochondrial-dependent amplification loop in ovarian cancer cell lines.
Cell death and differentiation 2004;11(5):527-41.
2004: Shengquan Liu; Chad W Brown; K Darrell Berlin; Arindam Dhar; Suresh Guruswamy; David Brown; Ginger J Gardner; Michael J Birrer; Doris M Benbrook
Synthesis of flexible sulfur-containing heteroarotinoids that induce apoptosis and reactive oxygen species with discrimination between malignant and benign cells.
Journal of medicinal chemistry 2004;47(4):999-1007.
2004: John J Farley; Catherine Uyehara; Glenn Hashiro; Christina Belnap; Michael J Birrer; Eric Salminen
Cyclooxygenase-2 expression predicts recurrence of cervical dysplasia following loop electrosurgical excision procedure.
Gynecologic oncology 2004;92(2):596-602.
2004: Hiroshi Tsuda; Christina A Bandera; Michael J Birrer; Yasunori Hashiguchi; Ross S Berkowitz; Samuel C Mok
Cyclin E amplification and overexpression in clear cell adenocarcinoma of the ovary.
Oncology 2004;67(3-4):291-9.
2003: John H Farley; Michael J Birrer
Biologic directed therapies in gynecologic oncology.
Current oncology reports 2003;5(6):459-67.
2003: Kristin K Zorn; Amir A Jazaeri; Christopher S Awtrey; Ginger J Gardner; Samuel C Mok; Jeff Boyd; Michael J Birrer
Choice of normal ovarian control influences determination of differentially expressed genes in ovarian cancer expression profiling studies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):4811-8.
2003: John Romashko; Stuart Horowitz; William R Franek; Thomas Palaia; Edmund Miller; Anning Lin; Michael J Birrer; William Scott; Lin L Mantell
MAPK pathways mediate hyperoxia-induced oncotic cell death in lung epithelial cells.
Free radical biology & medicine 2003;35(8):978-93.
2003: William E Winter; Jeffrey D Seidman; Thomas Krivak; Suman Chauhan; Jay W Carlson; G Scott Rose; Michael J Birrer
Clinicopathological analysis of c-kit expression in carcinosarcomas and leiomyosarcomas of the uterine corpus.
Gynecologic oncology 2003;91(1):3-8.
2003: Jane Trepel; Michael J Birrer
A link between histone deacetylase inhibitors and NF- kappaB signaling.
Cell cycle (Georgetown, Tex.) 2003;2(5):452-3.
2003: Virna D Leaner; Ichiro Kinoshita; Michael J Birrer
AP-1 complexes containing cJun and JunB cause cellular transformation of Rat1a fibroblasts and share transcriptional targets.
Oncogene 2003;22(36):5619-29.
2003: Ying H Shen; Jakub Godlewski; Jun Zhu; Pradeep Sathyanarayana; Virna D Leaner; Michael J Birrer; Ajay Rana; Guri Tzivion
Cross-talk between JNK/SAPK and ERK/MAPK pathways: sustained activation of JNK blocks ERK activation by mitogenic factors.
The Journal of biological chemistry 2003;278(29):26715-21.
2003: Ichiro Kinoshita; Virna D Leaner; Motoo Katabami; Ramon G Manzano; Paul Dent; Anita L Sabichi; Michael J Birrer
Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of stathmin is necessary for cJun-mediated anchorage-independent growth.
Oncogene 2003;22(18):2710-22.
2003: John Farley; Leia M Smith; Kathleen M Darcy; Eugene Sobel; Dennis O'Connor; Benita Henderson; Larry E Morrison; Michael J Birrer
Cyclin E expression is a significant predictor of survival in advanced, suboptimally debulked ovarian epithelial cancers: a Gynecologic Oncology Group study.
Cancer research 2003;63(6):1235-41.
2003: Ziad Zeinoun; Erik Teugels; Joanna Vermeij; Bart Neyns; Michael J Birrer; Jacques De Grève
Restoration of an impaired TGF-beta1 autocrine growth-inhibitory circuit results in growth inhibition of ovarian epithelial cancer cells and complete inhibition of their tumorigenicity.
Cancer detection and prevention 2003;27(5):380-8.
2003: Paul Dent; Liang Qiao; Donna Gilfor; Michael J Birrer; Steven Grant; Paul B Fisher
The regulation of tumor suppressor genes by oncogenes.
Methods in molecular biology (Clifton, N.J.) 2003;222():269-92.
2002: Judy Quong; Serenella Eppenberger-Castori; Dan Moore; Gary K Scott; Michael J Birrer; Willy Kueng; Urs Eppenberger; Christopher C Benz
Age-dependent changes in breast cancer hormone receptors and oxidant stress markers.
Breast cancer research and treatment 2002;76(3):221-36.
2002: Cai Bowen; Michael J Birrer; Edward P Gelmann
Retinoblastoma protein-mediated apoptosis after gamma-irradiation.
The Journal of biological chemistry 2002;277(47):44969-79.
2002: Ramon G Manzano; Luis M Montuenga; Mark Dayton; Paul Dent; Ichiro Kinoshita; Silvestre Vicent; Ginger J Gardner; Phuongmai Nguyen; Yung Hyun Choi; Jane Trepel; Nelly Auersperg; Michael J Birrer
CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential.
Oncogene 2002;21(28):4435-47.
2001: Ginger J Gardner; Michael J Birrer
Ovarian tumors of low malignant potential: Can molecular biology solve this enigma?
Journal of the National Cancer Institute 2001;93(15):1122-3.
2001: M Fan; Mary E Goodwin; Michael J Birrer; Timothy C Chambers
The c-Jun NH(2)-terminal protein kinase/AP-1 pathway is required for efficient apoptosis induced by vinblastine.
Cancer research 2001;61(11):4450-8.
2001: Thomas Krivak; John W McBroom; J Seidman; D Venzon; Barbara A Crothers; Paul J MacKoul; G Scott Rose; Jay W Carlson; Michael J Birrer
Abnormal fragile histidine triad (FHIT) expression in advanced cervical carcinoma: a poor prognostic factor.
Cancer research 2001;61(11):4382-5.
2001: M Ebina; Alfredo Martínez; Michael J Birrer; R Ilona Linnoila
In situ detection of unexpected patterns of mutant p53 gene expression in non-small cell lung cancers.
Oncogene 2001;20(20):2579-86.
2001: Lawrence R Nycum; L M Smith; John H Farley; Edward R Kost; M W Method; Michael J Birrer
The role of p27 in endometrial carcinoma.
Gynecologic oncology 2001;81(2):242-6.
2000: Joong Su Kim; F Pirnia; Young Hun Choi; P M Nguyen; B Knepper; Maria Tsokos; TW Schulte; Michael J Birrer; Mikhail V Blagosklonny; O Schaefer; J Frederic Mushinski; Jane Trepel
Lovastatin induces apoptosis in a primitive neuroectodermal tumor cell line in association with RB down-regulation and loss of the G1 checkpoint.
Oncogene 2000;19(52):6082-90.
2000: Michele D Vos; Chad A Ellis; A Bell; Michael J Birrer; Geoffrey J Clark
Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis.
The Journal of biological chemistry 2000;275(46):35669-72.
2000: A Paasinen-Sohns; Mari Kielosto; Essi Kääriäinen; T Eloranta; A Laine; Olli A Jänne; Michael J Birrer; Erkki Hölttä
c-Jun activation-dependent tumorigenic transformation induced paradoxically by overexpression or block of S-adenosylmethionine decarboxylase.
The Journal of cell biology 2000;151(4):801-10.
2000: J Rinehart-Kim; M Johnston; Michael J Birrer; Timothy J Bos
Alterations in the gene expression profile of MCF-7 breast tumor cells in response to c-Jun.
International journal of cancer. Journal international du cancer 2000;88(2):180-90.
2000: John H Farley; Lawrence R Nycum; Michael J Birrer; RC Park; RR Taylor
Age-specific survival of women with endometrioid adenocarcinoma of the uterus.
Gynecologic oncology 2000;79(1):86-9.
2000: J Farley; K Gray; Lawrence R Nycum; Margaret A Prentice; Michael J Birrer; Sonia B Jakowlew
Endocervical cancer is associated with an increase in the ligands and receptors for transforming growth factor-beta and a contrasting decrease in p27(Kip1).
Gynecologic oncology 2000;78(2):113-22.
2000: M J Schmitz; Denver T Hendricks; John Farley; RR Taylor; Joseph Geradts; G Scott Rose; Michael J Birrer
p27 and cyclin D1 abnormalities in uterine papillary serous carcinoma.
Gynecologic oncology 2000;77(3):439-45.
2000: Hongtao Liu; P Sidiropoulos; G Song; Lisa J Pagliari; Michael J Birrer; B Stein; J Anrather; Richard M Pope
TNF-alpha gene expression in macrophages: regulation by NF-kappa B is independent of c-Jun or C/EBP beta.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(8):4277-85.
2000: Leanne Cartee; Julie Vrana; Zhiliang Wang; Jong Sung Park; Michael J Birrer; Paul B Fisher; Steven Grant; Paul Dent
Inhibition of the mitogen activated protein kinase pathway potentiates radiation-induced cell killing via cell cycle arrest at the G2/M transition and independently of increased signaling by the JNK/c-Jun pathway.
International journal of oncology 2000;16(2):413-22.
2000: Jong Sung Park; S Boyer; K Mitchell; Donna Gilfor; Michael J Birrer; G Darlington; Wafik S El-Deiry; G L Firestone; K Munger; V Band; Paul B Fisher; Paul Dent
Expression of human papilloma virus E7 protein causes apoptosis and inhibits DNA synthesis in primary hepatocytes via increased expression of p21(Cip-1/WAF1/MDA6).
The Journal of biological chemistry 2000;275(1):18-28.
2000: Alfred C Johnson; Barbara A Murphy; C M Matelis; Yaffa R Rubinstein; E C Piebenga; L M Akers; G Neta; Charles Vinson; Michael J Birrer
Activator protein-1 mediates induced but not basal epidermal growth factor receptor gene expression.
Molecular medicine (Cambridge, Mass.) 2000;6(1):17-27.
1999: L M Smith; S C Wise; Denver T Hendricks; Anita L Sabichi; T Bos; P Reddy; P H Brown; Michael J Birrer
cJun overexpression in MCF-7 breast cancer cells produces a tumorigenic, invasive and hormone resistant phenotype.
Oncogene 1999;18(44):6063-70.
1999: Michael J Birrer; Denver T Hendricks; J Farley; M J Sundborg; Tomas Bonome; M J Walts; Joseph Geradts
Abnormal Fhit expression in malignant and premalignant lesions of the cervix.
Cancer research 1999;59(20):5270-4.
1999: Nanping Wang; Lynne Verna; S Hardy; Yi Zhu; KS Ma; Michael J Birrer; Michael B Stemerman
c-Jun triggers apoptosis in human vascular endothelial cells.
Circulation research 1999;85(5):387-93.
1999: Joseph Geradts; R Maynard; Michael J Birrer; Denver T Hendricks; S L Abbondanzo; Kwun M Fong; J C Barrett; D P Lombardi
Frequent loss of KAI1 expression in squamous and lymphoid neoplasms. An immunohistochemical study of archival tissues.
The American journal of pathology 1999;154(6):1665-71.
1999: GN Rao; K A Katki; Nageswara R Madamanchi; Yaxu Wu; Michael J Birrer
JunB forms the majority of the AP-1 complex and is a target for redox regulation by receptor tyrosine kinase and G protein-coupled receptor agonists in smooth muscle cells.
The Journal of biological chemistry 1999;274(9):6003-10.
1998: Paul Dent; W D Jarvis; Michael J Birrer; Paul B Fisher; R K Schmidt-Ullrich; Steven Grant
The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity.
Leukemia 1998;12(12):1843-50.
1998: Weiping Yu; Marla Menchaca; H You; P Brown; Michael J Birrer; Bob G Sanders; Kimberly Kline
RRR-alpha-tocopheryl succinate induction of prolonged activation of c-jun amino-terminal kinase and c-jun during induction of apoptosis in human MDA-MB-435 breast cancer cells.
Molecular carcinogenesis 1998;22(4):247-57.
1998: Sarah Helber; Amittha Wickrema; Michael J Birrer; Stephen T Sawyer
AP1 regulation of proliferation and initiation of apoptosis in erythropoietin-dependent erythroid cells.
Molecular and cellular biology 1998;18(7):3699-707.
1998: S Carter; KL Auer; DB Reardon; Michael J Birrer; Paul B Fisher; Kristoffer Valerie; Rupert K Schmidt-Ullrich; Ross B Mikkelsen; Paul Dent
Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells.
Oncogene 1998;16(21):2787-96.
1998: Alexander Zagariya; S Mungre; R Lovis; Michael J Birrer; S Ness; Bayar Thimmapaya; R Pope
Tumor necrosis factor alpha gene regulation: enhancement of C/EBPbeta-induced activation by c-Jun.
Molecular and cellular biology 1998;18(5):2815-24.
1998: S C Wise; L A Burmeister; Xiao-Feng Zhou; A Bubulya; J L Oberfield; Michael J Birrer; Lirim Shemshedini
Identification of domains of c-Jun mediating androgen receptor transactivation.
Oncogene 1998;16(15):2001-9.
1998: Anita L Sabichi; Denver T Hendricks; M A Bober; Michael J Birrer
Retinoic acid receptor beta expression and growth inhibition of gynecologic cancer cells by the synthetic retinoid N-(4-hydroxyphenyl) retinamide.
Journal of the National Cancer Institute 1998;90(8):597-605.
1998: Julius Leyton; T Coelho; David H Coy; Sonia B Jakowlew; Michael J Birrer; Terry W Moody
PACAP(6-38) inhibits the growth of prostate cancer cells.
Cancer letters 1998;125(1-2):131-9.
1998: KL Auer; Joseph N Contessa; Stefano Brenz-Verca; Luciano Pirola; S Rusconi; G Cooper; A Abo; M P Wymann; R J Davis; Michael J Birrer; Paul Dent
The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes.
Molecular biology of the cell 1998;9(3):561-73.
1998: E Szabo; J Francis; Michael J Birrer
Alterations in differentiation and apoptosis induced by bufalin in cJun overexpressing U-937 cells.
International journal of oncology 1998;12(2):403-9.
1997: W David Jarvis; FA Fornari; KL Auer; AJ Freemerman; E Szabo; Michael J Birrer; Charlene R Johnson; S E Barbour; Paul Dent; Steven Grant
Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine.
Molecular pharmacology 1997;52(6):935-47.
1997: L M Smith; Michael J Birrer; M R Stampfer; P H Brown
Breast cancer cells have lower activating protein 1 transcription factor activity than normal mammary epithelial cells.
Cancer research 1997;57(14):3046-54.
1997: B Zhao; Weiping Yu; M Qian; Marla Menchaca; P Brown; Michael J Birrer; Bob G Sanders; Kimberly Kline
Involvement of activator protein-1 (AP-1) in induction of apoptosis by vitamin E succinate in human breast cancer cells.
Molecular carcinogenesis 1997;19(3):180-90.
1997: Denver T Hendricks; R Taylor; M Reed; Michael J Birrer
FHIT gene expression in human ovarian, endometrial, and cervical cancer cell lines.
Cancer research 1997;57(11):2112-5.
1997: Olga Potapova; Ali Haghighi; Frédéric Bost; C Liu; Michael J Birrer; Ruth A Gjerset; Dan Mercola
The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin.
The Journal of biological chemistry 1997;272(22):14041-4.
1997: K L Hall; M G Teneriello; RR Taylor; S Lemon; M Ebina; RI Linnoila; J H Norris; RC Park; Michael J Birrer
Analysis of Ki-ras, p53, and MDM2 genes in uterine leiomyomas and leiomyosarcomas.
Gynecologic oncology 1997;65(2):330-5.
1997: Mary F Parker; G F Arroyo; Joseph Geradts; Anita L Sabichi; RC Park; RR Taylor; Michael J Birrer
Molecular characterization of adenocarcinoma of the cervix.
Gynecologic oncology 1997;64(2):242-51.
1997: Michael J Birrer
Discoveries in the cell cycle and ovarian cancer.
Gynecologic oncology 1997;64(2):187-8.
1997: Joseph R Pisegna; Julius Leyton; T Coelho; T Hida; Sonia B Jakowlew; Michael J Birrer; Mati Fridkin; Illana Gozes; Terry W Moody
PACAP hybrid: a new PACAP receptor antagonist.
Life sciences 1997;61(6):631-9.
1996: L M Smith; Michael J Birrer
Use of transcription factors as agents and targets for drug development.
Oncology (Williston Park, N.Y.) 1996;10(10):1532-8; discussion 1541-2.
1996: P H Brown; S H Kim; S C Wise; Anita L Sabichi; Michael J Birrer
Dominant-negative mutants of cJun inhibit AP-1 activity through multiple mechanisms and with different potencies.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(8):1013-21.
1996: H Zia; T Hida; Sonia B Jakowlew; Michael J Birrer; Y Gozes; J C Reubi; Mati Fridkin; Illana Gozes; Terry W Moody
Breast cancer growth is inhibited by vasoactive intestinal peptide (VIP) hybrid, a synthetic VIP receptor antagonist.
Cancer research 1996;56(15):3486-9.
1996: Steven Grant; AJ Freemerman; Michael J Birrer; H A Martin; A J Turner; E Szabo; J Chelliah; W David Jarvis
Effect of 1-beta-D-arabinofuranosylcytosine on apoptosis and differentiation in human monocytic leukemia cells (U937) expressing a c-Jun dominant-negative mutant protein (TAM67).
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(5):603-13.
1996: AJ Freemerman; A J Turner; Michael J Birrer; E Szabo; K Valerie; Steven Grant
Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase C.
Molecular pharmacology 1996;49(5):788-95.
1996: M J Antinore; Michael J Birrer; D Patel; L Nader; Dennis J McCance
The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors.
The EMBO journal 1996;15(8):1950-60.
1996: S Kim; P H Brown; Michael J Birrer
The inhibitory activity of a transdominant c-jun mutant fused to the ligand binding domain of the estrogen receptor.
Oncogene 1996;12(5):1043-53.
1996: Marcel Verheij; R Bose; X H Lin; B Yao; W David Jarvis; Steven Grant; Michael J Birrer; E Szabo; L I Zon; J M Kyriakis; Adriana Haimovitz-Friedman; Zvi Fuks; Richard Kolesnick
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.
Nature 1996;380(6569):75-9.
1996: T K Chen; L M Smith; D K Gebhardt; Michael J Birrer; P H Brown
Activation and inhibition of the AP-1 complex in human breast cancer cells.
Molecular carcinogenesis 1996;15(3):215-26.
1996: E Szabo; M E Riffe; Seth M Steinberg; Michael J Birrer; RI Linnoila
Altered cJUN expression: an early event in human lung carcinogenesis.
Cancer research 1996;56(2):305-15.
1996: Anita L Sabichi; Michael J Birrer
Regulation of nuclear oncogenes expressed in lung cancer cell lines.
Journal of cellular biochemistry. Supplement 1996;24():218-27.
1996: M Draoui; T Hida; Sonia B Jakowlew; Michael J Birrer; Farah zia; Terry W Moody
PACAP stimulates c-fos mRNAs in small cell lung cancer cells.
Life sciences 1996;59(4):307-13.
1995: E Lengye; B Singh; R Gum; C Nerlov; A Sabichi; Michael J Birrer; D Boyd
Regulation of urokinase-type plasminogen activator expression by the v-mos oncogene.
Oncogene 1995;11(12):2639-48.
1995: RR Taylor; RI Linnoila; J Gerardts; M G Teneriello; J D Nash; R C Park; Michael J Birrer
Abnormal expression of the retinoblastoma gene in ovarian neoplasms and correlation to p53 and K-ras mutations.
Gynecologic oncology 1995;58(3):307-11.
1995: Michael J Birrer
Translational research and epithelial carcinogenesis: molecular diagnostic assays now--molecular screening assays soon?
Journal of the National Cancer Institute 1995;87(14):1041-3.
1995: M Cippitelli; A Sica; V Viggiano; J Ye; P Ghosh; Michael J Birrer; Howard A Young
Negative transcriptional regulation of the interferon-gamma promoter by glucocorticoids and dominant negative mutants of c-Jun.
The Journal of biological chemistry 1995;270(21):12548-56.
1995: R G Watts; E T Ben-Ari; L R Bernstein; Michael J Birrer; D Winterstein; E Wendel; Nancy H Colburn
c-jun and multistage carcinogenesis: association of overexpression of introduced c-jun with progression toward a neoplastic endpoint in mouse JB6 cells sensitive to tumor promoter-induced transformation.
Molecular carcinogenesis 1995;13(1):27-36.
1995: M Draoui; P Chung; M Park; Michael J Birrer; Sonia B Jakowlew; Terry W Moody
Bombesin stimulates c-fos and c-jun mRNAs in small cell lung cancer cells.
Peptides 1995;16(2):289-92.
1994: U R Rapp; J Troppmair; T Beck; Michael J Birrer
Transformation by Raf and other oncogenes renders cells differentially sensitive to growth inhibition by a dominant negative c-jun mutant.
Oncogene 1994;9(12):3493-8.
1994: RR Taylor; M G Teneriello; J D Nash; R C Park; Michael J Birrer
The molecular genetics of gyn malignancies.
Oncology (Williston Park, N.Y.) 1994;8(10):63-70, 73; discussion 73, 78-82.
1994: D Petrak; S A Memon; Michael J Birrer; Jonathan D Ashwell; C M Zacharchuk
Dominant negative mutant of c-Jun inhibits NF-AT transcriptional activity and prevents IL-2 gene transcription.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):2046-51.
1994: E Szabo; L H Preis; Michael J Birrer
Constitutive cJun expression induces partial macrophage differentiation in U-937 cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(4):439-46.
1994: P H Brown; T K Chen; Michael J Birrer
Mechanism of action of a dominant-negative mutant of c-Jun.
Oncogene 1994;9(3):791-9.
1994: Z Dong; Michael J Birrer; R G Watts; L M Matrisian; Nancy H Colburn
Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(2):609-13.
1994: F E Domann; J P Levy; Michael J Birrer; George Bowden
Stable expression of a c-JUN deletion mutant in two malignant mouse epidermal cell lines blocks tumor formation in nude mice.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(1):9-16.
1993: J M Kurie; P Brown; E Salk; David A Scheinberg; Michael J Birrer; P Deutsch; Ethan Dmitrovsky
Cooperation between retinoic acid and phorbol esters enhances human teratocarcinoma differentiation.
Differentiation; research in biological diversity 1993;54(2):115-22.
1993: E Szabo; Michael J Birrer; James L Mulshine
Early detection of lung cancer.
Seminars in oncology 1993;20(4):374-82.
1993: M G Teneriello; M Ebina; RI Linnoila; M Henry; J D Nash; R C Park; Michael J Birrer
p53 and Ki-ras gene mutations in epithelial ovarian neoplasms.
Cancer research 1993;53(13):3103-8.
1993: Anita L Sabichi; Michael J Birrer
The molecular biology of lung cancer: application to early detection and prevention.
Oncology (Williston Park, N.Y.) 1993;7(6):19-26; discussion 31-2, 37.
1993: P H Brown; Rhoda M Alani; L H Preis; E Szabo; Michael J Birrer
Suppression of oncogene-induced transformation by a deletion mutant of c-jun.
Oncogene 1993;8(4):877-86.
1993: James L Mulshine; AM Treston; P H Brown; Michael J Birrer; G L Shaw
Initiators and promoters of lung cancer.
Chest 1993;103(1 Suppl):4S-11S.
1992: J Barrett; Michael J Birrer; Gregory Kato ; H Dosaka-Akita; Chi Dang
Activation domains of L-Myc and c-Myc determine their transforming potencies in rat embryo cells.
Molecular and cellular biology 1992;12(7):3130-7.
1992: Michael J Birrer; P H Brown
Application of molecular genetics to the early diagnosis and screening of lung cancer.
Cancer research 1992;52(9 Suppl):2658s-2664s.
1992: M Bar-Ner; L T Messing; C M Cultraro; Michael J Birrer; S Segal
Regions within the c-Myc protein that are necessary for transformation are also required for inhibition of differentiation of murine erythroleukemia cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992;3(3):183-90.
1992: James L Mulshine; RI Linnoila; AM Treston; F M Scott; K Quinn; Ingalill Avis; G L Shaw; S M Jensen; P Brown; Michael J Birrer
Candidate biomarkers for application as intermediate end points of lung carcinogenesis.
Journal of cellular biochemistry. Supplement 1992;16G():183-6.
1992: James L Mulshine; Michael J Birrer; AM Treston; F Scott; K Quinn; Ingalill Avis; Frank Cuttitta
Growth factors and other targets for rational application as intervention agents.
Advances in experimental medicine and biology 1992;320():81-8.
1992: Michael J Birrer; Rhoda M Alani; Frank Cuttitta; L H Preis; A L Sabich; D A Sanders; J M Siegfried; E Szabo; P H Brown
Early events in the neoplastic transformation of respiratory epithelium.
Journal of the National Cancer Institute. Monographs 1992;(13):31-7.
1992: James L Mulshine; RI Linnoila; S M Jensen; J L Magnani; M S Tockman; P K Gupta; F S Scott; Ingalill Avis; K Quinn; Michael J Birrer
Rational targets for the early detection of lung cancer.
Journal of the National Cancer Institute. Monographs 1992;(13):183-90.
1991: T Smeal; B Binetruy; Dan Mercola; Michael J Birrer; Michael Karin
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73.
Nature 1991;354(6353):494-6.
1991: Rhoda M Alani; P Brown; B Binétruy; H Dosaka; R K Rosenberg; P Angel; Michael Karin; Michael J Birrer
The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells.
Molecular and cellular biology 1991;11(12):6286-95.
1991: E Szabo; L H Preis; P H Brown; Michael J Birrer
The role of jun and fos gene family members in 12-O-tetradecanoylphorbol-13-acetate induced hemopoietic differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(10):475-82.
1991: J H Kim; T Takahashi; I Chiba; J G Park; Michael J Birrer; J K Roh; H De Lee; J P Kim; John D Minna; Adi F Gazdar
Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines.
Journal of the National Cancer Institute 1991;83(13):938-43.
1991: H Dosaka-Akita; R K Rosenberg; John D Minna; Michael J Birrer
A complex pattern of translational initiation and phosphorylation in L-myc proteins.
Oncogene 1991;6(3):371-8.
1990: D P Bliss; James F Battey; RI Linnoila; Michael J Birrer; Adi F Gazdar; Bruce E Johnson
Expression of the atrial natriuretic factor gene in small cell lung cancer tumors and tumor cell lines.
Journal of the National Cancer Institute 1990;82(4):305-10.
1989: T Takahashi; Marion M Nau; I Chiba; Michael J Birrer; R K Rosenberg; M Vinocour; M Levitt; Harvey I Pass; Adi F Gazdar; John D Minna
p53: a frequent target for genetic abnormalities in lung cancer.
Science (New York, N.Y.) 1989;246(4929):491-4.
1989: Michael J Birrer; L Raveh; H Dosaka; S Segal
A transfected L-myc gene can substitute for c-myc in blocking murine erythroleukemia differentiation.
Molecular and cellular biology 1989;9(6):2734-7.
1989: J Schütte; John D Minna; Michael J Birrer
Deregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms rat-1a cells as a single gene.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2257-61.
1989: Michael J Birrer; John D Minna
Genetic changes in the pathogenesis of lung cancer.
Annual review of medicine 1989;40():305-17.
1989: John D Minna; J Schütte; J Viallet; F Thomas; Frederic J Kaye; T Takahashi; Marion M Nau; J Whang-Peng; Michael J Birrer; Adi F Gazdar
Transcription factors and recessive oncogenes in the pathogenesis of human lung cancer.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1989;4():32-4.
1988: J De Greve; J Battey; J Fedorko; Michael J Birrer; G Evan; Frederic J Kaye; Edward A Sausville; John D Minna
The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs.
Molecular and cellular biology 1988;8(10):4381-8.
1988: G Krystal; Michael J Birrer; J Way; Marion M Nau; Edward A Sausville; Craig Thompson; John D Minna; J Battey
Multiple mechanisms for transcriptional regulation of the myc gene family in small-cell lung cancer.
Molecular and cellular biology 1988;8(8):3373-81.
1988: Michael J Birrer; John D Minna
Molecular genetics of lung cancer.
Seminars in oncology 1988;15(3):226-35.
1988: Michael J Birrer; S Segal; J S DeGreve; Frederic J Kaye; Edward A Sausville; John D Minna
L-myc cooperates with ras to transform primary rat embryo fibroblasts.
Molecular and cellular biology 1988;8(6):2668-73.
1988: Frederic J Kaye; J Battey; Marion M Nau; B Brooks; E Seifter; J De Greve; Michael J Birrer; Edward A Sausville; John D Minna
Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing.
Molecular and cellular biology 1988;8(1):186-95.
1987: Michael J Birrer; R C Young
Differential diagnosis of jaundice in lymphoma patients.
Seminars in liver disease 1987;7(3):269-77.
1986: John D Minna; James F Battey; Michael J Birrer; B J Brooks; Frank Cuttitta; J DeGreve; Adi F Gazdar; Bruce E Johnson; Marion M Nau; Edward A Sausville
Chromosomal deletion, gene amplification, alternative processing, and autocrine growth factor production in the pathogenesis of human lung cancer.
Princess Takamatsu symposia 1986;17():109-22.
1981: Michael J Birrer; S Udem; Stanley G Nathenson; B R Bloom
Antigenic variants of measles virus.
Nature 1981;293(5827):67-9.
1981: Michael J Birrer; B R Bloom; S Udem
Characterization of measles polypeptides by monoclonal antibodies.
Virology 1981;108(2):381-90.
1980: G Ju; Michael J Birrer; S Udem; B R Bloom
Complementation analysis of measles virus mutants isolated from persistently infected lymphoblastoid cell lines.
Journal of virology 1980;33(3):1004-12.