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Elizabeth Birzin

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J A Clark; Lawrence F Colwell; R Fleischer; R Flick; Chrisana Gundlah; M Hammond; E Hayes; K Ho; S Li; E Mattingly; Lee-Yuh Pai; B Rocha; James M Schaeffer; Sudha Warrier; R Wilkening; Hilary A Wilkinson; Joel B Yudkovitz; S Alves; Elizabeth T Birzin; S-J Cai; Susan P Rohrer
Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tryptophan hydroxylase-1 (TPH-1) mRNA expression and cause antidepressant-like effects in the forced swim test.
Evan E Opas; Angela Scafonas; Pascale V Nantermet; Robert R Wilkening; Elizabeth T Birzin; Hilary Wilkinson; Lawrence F Colwell; James M Schaeffer; Dwight A Towler; Gideon A Rodan; Azriel Schmidt
Control of rat tail skin temperature regulation by estrogen receptor-beta selective ligand.
Angela Scafonas; Alfred A Reszka; Donald B Kimmel; Xiaoli Shirley Hou; Qin Su; Elizabeth T Birzin; Seongkon Kim; Helen Y Chen; Qiang Tan; Susan P Roher; Frank DiNinno; Milton L Hammond; Gideon A Rodan; Dwight A Towler; Azriel Schmidt
Agonist-like SERM effects on ERalpha-mediated repression of MMP1 promoter activity predict in vivo effects on bone and uterus.

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All Publications

2012: J A Clark; Lawrence F Colwell; R Fleischer; R Flick; Chrisana Gundlah; M Hammond; E Hayes; K Ho; S Li; E Mattingly; Lee-Yuh Pai; B Rocha; James M Schaeffer; Sudha Warrier; R Wilkening; Hilary A Wilkinson; Joel B Yudkovitz; S Alves; Elizabeth T Birzin; S-J Cai; Susan P Rohrer
Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tryptophan hydroxylase-1 (TPH-1) mRNA expression and cause antidepressant-like effects in the forced swim test.
Neuropharmacology 2012;63(6):1051-63.
2009: Evan E Opas; Angela Scafonas; Pascale V Nantermet; Robert R Wilkening; Elizabeth T Birzin; Hilary Wilkinson; Lawrence F Colwell; James M Schaeffer; Dwight A Towler; Gideon A Rodan; Azriel Schmidt
Control of rat tail skin temperature regulation by estrogen receptor-beta selective ligand.
Maturitas 2009;64(1):46-51.
2008: Angela Scafonas; Alfred A Reszka; Donald B Kimmel; Xiaoli Shirley Hou; Qin Su; Elizabeth T Birzin; Seongkon Kim; Helen Y Chen; Qiang Tan; Susan P Roher; Frank DiNinno; Milton L Hammond; Gideon A Rodan; Dwight A Towler; Azriel Schmidt
Agonist-like SERM effects on ERalpha-mediated repression of MMP1 promoter activity predict in vivo effects on bone and uterus.
The Journal of steroid biochemistry and molecular biology 2008;110(3-5):197-206.
2007: Timothy A Blizzard; Candido Gude; Jerry D Morgan; Wanda Chan; Elizabeth T Birzin; Marina Mojena; Consuelo Tudela; Fang Chen; Kristin Knecht; Qin Su; Bryan Kraker; Ralph T Mosley; Mark A Holmes; Susan P Rohrer; Milton L Hammond
Androstene-3,5-dienes as ER-beta selective SERMs.
Bioorganic & medicinal chemistry letters 2007;17(22):6295-8.
2007: Timothy A Blizzard; Candido Gude; Wanda Chan; Elizabeth T Birzin; Marina Mojena; Consuelo Tudela; Fang Chen; Kristin Knecht; Qin Su; Bryan Kraker; Mark A Holmes; Susan P Rohrer; Milton L Hammond
Bridged androstenediol analogs as ER-beta selective SERMs.
Bioorganic & medicinal chemistry letters 2007;17(10):2944-8.
2007: Kevin D Dykstra; Liangqin Guo; Elizabeth T Birzin; Wanda Chan; Yi Tien Yang; Edward C Hayes; Carolyn A DaSilva; Lee-Yuh Pai; Ralph T Mosley; Bryan Kraker; Paula M D Fitzgerald; Frank DiNinno; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERalpha.
Bioorganic & medicinal chemistry letters 2007;17(8):2322-8.
2006: Mathias Z Strowski; Doreen E Cashen; Elizabeth T Birzin; Lihu Yang; Vandana Singh; Thomas M Jacks; Krzysztof W Nowak; Susan P Rohrer; Arthur A Patchett; Roy G Smith; James M Schaeffer
Antidiabetic activity of a highly potent and selective nonpeptide somatostatin receptor subtype-2 agonist.
Endocrinology 2006;147(10):4664-73.
2006: Kenneth J Wildonger; Ronald W Ratcliffe; Ralph T Mosley; Milton L Hammond; Elizabeth T Birzin; Susan P Rohrer
Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands.
Bioorganic & medicinal chemistry letters 2006;16(17):4462-6.
2006: Dann L Parker; Dongfang Meng; Ronald W Ratcliffe; Robert R Wilkening; Donald M Sperbeck; Mark L Greenlee; Lawrence F Colwell; Sherrie Lambert; Elizabeth T Birzin; Katalin Frisch; Susan P Rohrer; Stefan Nilsson; Ann-Gerd Thorsell; Milton L Hammond
Triazolo-tetrahydrofluorenones as selective estrogen receptor beta agonists.
Bioorganic & medicinal chemistry letters 2006;16(17):4652-6.
2006: Robert R Wilkening; Ronald W Ratcliffe; A K Fried; D Meng; W Sun; Lawrence F Colwell; S Lambert; Mark L Greenlee; Stefan Nilsson; Ann-Gerd Thorsell; Marina Mojena; Consuelo Tudela; Katalin Frisch; Wanda Chan; Elizabeth T Birzin; Susan P Rohrer; Milton L Hammond
Estrogen receptor beta-subtype selective tetrahydrofluorenones: use of a fused pyrazole as a phenol bioisostere.
Bioorganic & medicinal chemistry letters 2006;16(15):3896-901.
2006: Robert R Wilkening; Ronald W Ratcliffe; E C Tynebor; Kenneth J Wildonger; A K Fried; Milton L Hammond; Ralph T Mosley; Paula M D Fitzgerald; Nandini Sharma; Brian McKeever; Stefan Nilsson; M Carlquist; Ann-Gerd Thorsell; Louis Locco; R Katz; Katalin Frisch; Elizabeth T Birzin; Hilary A Wilkinson; S Mitra; S Cai; Edward C Hayes; James M Schaeffer; Susan P Rohrer
The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands.
Bioorganic & medicinal chemistry letters 2006;16(13):3489-94.
2006: Wanying Sun; Lovji D Cama; Elizabeth T Birzin; Sudha Warrier; Louis Locco; Ralph T Mosley; Milton L Hammond; Susan P Rohrer
6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists.
Bioorganic & medicinal chemistry letters 2006;16(6):1468-72.
2006: Lorraine Lipfert; John E Fisher; Nan Wei; Angela Scafonas; Qin Su; Joel B Yudkovitz; Fang Chen; Sudha Warrier; Elizabeth T Birzin; Seongkon Kim; Helen Y Chen; Qiang Tan; Azriel Schmidt; Frank DiNinno; Susan P Rohrer; Milton L Hammond; Gideon A Rodan; Leonard P Freedman; Alfred A Reszka
Antagonist-induced, activation function-2-independent estrogen receptor alpha phosphorylation.
Molecular endocrinology (Baltimore, Md.) 2006;20(3):516-33.
2006: Timothy A Blizzard; Candido Gude; Jerry D Morgan; Wanda Chan; Elizabeth T Birzin; Marina Mojena; Consuelo Tudela; Fang Chen; Kristin Knecht; Qin Su; Bryan Kraker; Ralph T Mosley; Mark A Holmes; Nandini Sharma; Paula M D Fitzgerald; Susan P Rohrer; Milton L Hammond
Androstenediol analogs as ER-beta-selective SERMs.
Bioorganic & medicinal chemistry letters 2006;16(4):834-8.
2005: Timothy A Blizzard; Jerry D Morgan; Wanda Chan; Elizabeth T Birzin; Lee-Yuh Pai; Edward C Hayes; Carolyn A DaSilva; Ralph T Mosley; Yi Tien Yang; Susan P Rohrer; Frank DiNinno; Milton L Hammond
Estrogen receptor ligands. Part 14: application of novel antagonist side chains to existing platforms.
Bioorganic & medicinal chemistry letters 2005;15(23):5124-8.
2005: Fang Chen; Kristin Knecht; Elizabeth T Birzin; John Fisher; Hilary A Wilkinson; Marina Mojena; Consuelo Tudela Moreno; Azriel Schmidt; Shun-ichi Harada; Leonard P Freedman; Alfred A Reszka
Direct agonist/antagonist functions of dehydroepiandrosterone.
Endocrinology 2005;146(11):4568-76.
2005: Timothy A Blizzard; Frank DiNinno; Helen Y Chen; Seongkon Kim; Jane Y Wu; Wanda Chan; Elizabeth T Birzin; Yi Tien Yang; Lee-Yuh Pai; Edward C Hayes; Carolyn A DaSilva; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 13: Dihydrobenzoxathiin SERAMs with an optimized antagonist side chain.
Bioorganic & medicinal chemistry letters 2005;15(17):3912-6.
2005: Santhosh Neelamkavil; Byron H Arison; Elizabeth T Birzin; Jin-Jye Feng; Kuo-Hsin Chen; Atsui Lin; Fong-Chi Cheng; Laurie Taylor; Edward R Thornton; Amos B Smith; Ralph Hirschmann
Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSST2 and hSST4. An unexpected effect of the chirality of Trp8 on NMR spectra in methanol.
Journal of medicinal chemistry 2005;48(12):4025-30.
2005: Angie R Angeles; Irina Neagu; Elizabeth T Birzin; Edward R Thornton; Amos B Smith; Ralph Hirschmann
Synthesis and binding affinities of novel SRIF-mimicking beta-D-glucosides satisfying the requirement for a pi-cloud at C1.
Organic letters 2005;7(6):1121-4.
2005: Qiang Tan; Timothy A Blizzard; Jerry D Morgan; Elizabeth T Birzin; Wanda Chan; Yi Tien Yang; Lee-Yuh Pai; Edward C Hayes; Carolyn A DaSilva; Sudha Warrier; Joel B Yudkovitz; Hilary A Wilkinson; Nandini Sharma; Paula M D Fitzgerald; Susan Li; Lawrence F Colwell; John E Fisher; Sharon Adamski; Alfred A Reszka; Donald B Kimmel; Frank DiNinno; Susan P Rohrer; Leonard P Freedman; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.
Bioorganic & medicinal chemistry letters 2005;15(6):1675-81.
2005: Jian Liu; Elizabeth T Birzin; Wanda Chan; Yi Tien Yang; Lee-Yuh Pai; Carolyn A DaSilva; Edward C Hayes; Ralph T Mosley; Frank DiNinno; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans.
Bioorganic & medicinal chemistry letters 2005;15(3):715-8.
2005: Timothy A Blizzard; Frank DiNinno; Jerry D Morgan; Helen Y Chen; Jane Y Wu; Seongkon Kim; Wanda Chan; Elizabeth T Birzin; Yi Tien Yang; Lee-Yuh Pai; Paula M D Fitzgerald; Nandini Sharma; Ying Li; Zhoupeng Zhang; Edward C Hayes; Carolyn A DaSilva; Wei Tang; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
Bioorganic & medicinal chemistry letters 2005;15(1):107-13.
2004: Timothy A Blizzard; Frank DiNinno; Jerry D Morgan; Jane Y Wu; Helen Y Chen; Seongkon Kim; Wanda Chan; Elizabeth T Birzin; Yi Tien Yang; Lee-Yuh Pai; Zhoupeng Zhang; Edward C Hayes; Carolyn A DaSilva; Wei Tang; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains.
Bioorganic & medicinal chemistry letters 2004;14(15):3865-8.
2004: Timothy A Blizzard; Frank DiNinno; Jerry D Morgan; Helen Y Chen; Jane Y Wu; Candido Gude; Seongkon Kim; Wanda Chan; Elizabeth T Birzin; Yi Tien Yang; Lee-Yuh Pai; Zhoupeng Zhang; Edward C Hayes; Carolyn A DaSilva; Wei Tang; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains.
Bioorganic & medicinal chemistry letters 2004;14(15):3861-4.
2004: Qiang Tan; Elizabeth T Birzin; Wanda Chan; Yi Tien Yang; Lee-Yuh Pai; Edward C Hayes; Carolyn A DaSilva; Frank DiNinno; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 6: Synthesis and binding affinity of dihydrobenzodithiins.
Bioorganic & medicinal chemistry letters 2004;14(14):3753-5.
2004: Qiang Tan; Elizabeth T Birzin; Wanda Chan; Yi Tien Yang; Lee-Yuh Pai; Edward C Hayes; Carolyn A DaSilva; Frank DiNinno; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 5: The SAR of dihydrobenzoxathiins containing modified basic side chains.
Bioorganic & medicinal chemistry letters 2004;14(14):3747-51.
2004: Seongkon Kim; Jane Wu; Helen Y Chen; Elizabeth T Birzin; Wanda Chan; Yi Tien Yang; Lawrence F Colwell; Susan Li; Johanna Dahllund; Frank DiNinno; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 4: The SAR of the syn-dihydrobenzoxathiin SERAMs.
Bioorganic & medicinal chemistry letters 2004;14(11):2741-5.
2004: Helen Y Chen; Seongkon Kim; Jane Y Wu; Elizabeth T Birzin; Wanda Chan; Yi Tien Yang; Johanna Dahllund; Frank DiNinno; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs.
Bioorganic & medicinal chemistry letters 2004;14(10):2551-4.
2004: Seongkon Kim; Jane Y Wu; Elizabeth T Birzin; Katalin Frisch; Wanda Chan; Lee-Yuh Pai; Yi Tien Yang; Ralph T Mosley; Paula M D Fitzgerald; Nandini Sharma; Johanna Dahllund; Ann-Gerd Thorsell; Frank DiNinno; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators.
Journal of medicinal chemistry 2004;47(9):2171-5.
2004: Helen Y Chen; Kevin D Dykstra; Elizabeth T Birzin; Katalin Frisch; Wanda Chan; Yi Tien Yang; Ralph T Mosley; Frank DiNinno; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity.
Bioorganic & medicinal chemistry letters 2004;14(6):1417-21.
2004: Timothy A Blizzard; Ralph T Mosley; Elizabeth T Birzin; Wanda Chan; Milton L Hammond
Comparison of 2-phenylspiroindenes and 2-phenylspiroindenediones as estrogen receptor ligands--modeling and binding data don't agree!
Bioorganic & medicinal chemistry letters 2004;14(5):1317-21.
2003: Norbert T Peekhaus; Marc Ferrer; Tina Chang; Oleg Kornienko; Jonathan E Schneeweis; Todd S Smith; Ira Hoffman; Lyndon J Mitnaul; Jayne Chin; Paul A Fischer; Timothy A Blizzard; Elizabeth T Birzin; Wanda Chan; James Inglese; Berta Strulovici; Susan P Rohrer; James M Schaeffer
A beta-lactamase-dependent Gal4-estrogen receptor beta transactivation assay for the ultra-high throughput screening of estrogen receptor beta agonists in a 3456-well format.
Assay and drug development technologies 2003;1(6):789-800.
2003: Vidya Prasad; Elizabeth T Birzin; Cheryl T McVaugh; Rachel D Van Rijn; Susan P Rohrer; Gary G Chicchi; Dennis J Underwood; Edward R Thornton; Amos B Smith; Ralph Hirschmann
Effects of heterocyclic aromatic substituents on binding affinities at two distinct sites of somatostatin receptors. Correlation with the electrostatic potential of the substituents.
Journal of medicinal chemistry 2003;46(10):1858-69.
2003: Timothy A Blizzard; Jerry D Morgan; Ralph T Mosley; Elizabeth T Birzin; Katalin Frisch; Susan P Rohrer; Milton L Hammond
2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs).
Bioorganic & medicinal chemistry letters 2003;13(3):479-83.
2002: Elizabeth T Birzin; Susan P Rohrer
High-throughput receptor-binding methods for somatostatin receptor 2.
Analytical biochemistry 2002;307(1):159-66.
2001: Changyou Zhou; Liangqin Guo; Gregori J Morriello; Alexander Pasternak; Y Pan; Susan P Rohrer; Elizabeth T Birzin; S E Huskey; Thomas M Jacks; Klaus D Schleim; Kang Cheng; James M Schaeffer; Arthur A Patchett; Lihu Yang
Nipecotic and iso-nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists.
Bioorganic & medicinal chemistry letters 2001;11(3):415-7.
2000: Zhixiong Ye; Y Gao; Raman K Bakshi; Meng-Hsin Chen; Susan P Rohrer; Scott Feighner; Sheng-Shung Pong; Andrew D Howard; A Blake; Elizabeth T Birzin; Louis Locco; Rupa M Parmar; Wanda W-S Chan; James M Schaeffer; Roy G Smith; Arthur A Patchett; Ravi P Nargund
Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues.
Bioorganic & medicinal chemistry letters 2000;10(1):5-8.
1999: Scott Berk; Susan P Rohrer; SJ Degrado; Elizabeth T Birzin; Ralph T Mosley; Steven M Hutchins; Alexander Pasternak; James M Schaeffer; Dennis J Underwood; Kevin Chapman
A combinatorial approach toward the discovery of non-peptide, subtype-selective somatostatin receptor ligands.
Journal of combinatorial chemistry 1999;1(5):388-96.
1999: Alexander Pasternak; Y Pan; D Marino; P E Sanderson; Ralph T Mosley; Susan P Rohrer; Elizabeth T Birzin; S E Huskey; Thomas M Jacks; Klaus D Schleim; Kang Cheng; James M Schaeffer; Arthur A Patchett; Lihu Yang
Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization.
Bioorganic & medicinal chemistry letters 1999;9(3):491-6.
1998: Susan P Rohrer; Elizabeth T Birzin; Ralph T Mosley; Scott Berk; Steven M Hutchins; Dong-Ming Shen; Y Xiong; Edward C Hayes; Rupa M Parmar; F Foor; Sudha Warrier Mitra; SJ Degrado; M Shu; J M Klopp; S J Cai; A Blake; Wanda W-S Chan; Alexander Pasternak; Lihu Yang; Arthur A Patchett; Roy G Smith; Kevin Chapman; James M Schaeffer
Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.
Science (New York, N.Y.) 1998;282(5389):737-40.
1998: Lihu Yang; Scott Berk; Susan P Rohrer; Ralph T Mosley; Liangqin Guo; Dennis J Underwood; Byron H Arison; Elizabeth T Birzin; Edward C Hayes; Sudha Warrier Mitra; Rupa M Parmar; Kang Cheng; Tsuei-Ju Wu; B S Butler; F Foor; Alexander Pasternak; Y Pan; M Silva; Roger M Freidinger; Roy G Smith; Kevin Chapman; James M Schaeffer; Arthur A Patchett
Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10836-41.
1998: Lihu Yang; Liangqin Guo; Alexander Pasternak; Ralph T Mosley; Susan P Rohrer; Elizabeth T Birzin; F Foor; Kang Cheng; James M Schaeffer; Arthur A Patchett
Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists.
Journal of medicinal chemistry 1998;41(13):2175-9.
1996: A Tsipouras; A A Adefarati; J S Tkacz; E G Frazier; Susan P Rohrer; Elizabeth T Birzin; A Rosegay; Deborah L Zink; Michael A Goetz; S B Singh; James M Schaeffer
Ophiobolin M and analogues, noncompetitive inhibitors of ivermectin binding with nematocidal activity.
Bioorganic & medicinal chemistry 1996;4(4):531-6.
1995: Susan P Rohrer; Elizabeth T Birzin; S D Costa; JP Arena; Edward C Hayes; James M Schaeffer
Identification of neuron-specific ivermectin binding sites in Drosophila melanogaster and Schistocerca americana.
Insect biochemistry and molecular biology 1995;25(1):11-7.
1994: Susan P Rohrer; E B Jacobson; Edward C Hayes; Elizabeth T Birzin; James M Schaeffer
Immunoaffinity purification of avermectin-binding proteins from the free-living nematode Caenorhabditis elegans and the fruitfly Drosophila melanogaster.
The Biochemical journal 1994;302 ( Pt 2)():339-45.
1994: Susan P Rohrer; Elizabeth T Birzin; C H Eary; James M Schaeffer; W L Shoop
Ivermectin binding sites in sensitive and resistant Haemonchus contortus.
The Journal of parasitology 1994;80(3):493-7.