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Reijo Salovaara

Research Profile

Disorders

Chemicals & Drugs

Physiology

Procedures

DNA Mutational Analysis

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Päivi Laiho; Antti Kokko; Sakari Vanharanta; Reijo Salovaara; Heli Sammalkorpi; Heikki Järvinen; Jukka-Pekka Mecklin; Tuomo J Karttunen; Karoliina Tuppurainen; Veronica Davalos; Simó Schwartz; Diego Arango; Markus Makinen; Lauri A Aaltonen
Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis.
Heli J Lehtonen; Maija Kiuru; Sanna K Ylisaukko-oja; Reijo Salovaara; Riitta Herva; Pasi A Koivisto; Outi Vierimaa; Kristiina Aittomäki; Eero Pukkala; Virpi Launonen; Lauri A Aaltonen
Increased risk of cancer in patients with fumarate hydratase germline mutation.
Tuija Hienonen; Reijo Salovaara; Jukka-Pekka Mecklin; Heikki Järvinen; Auli Karhu; Lauri A Aaltonen
Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers.

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All Publications

2007: Päivi Laiho; Antti Kokko; Sakari Vanharanta; Reijo Salovaara; Heli Sammalkorpi; Heikki Järvinen; Jukka-Pekka Mecklin; Tuomo J Karttunen; Karoliina Tuppurainen; Veronica Davalos; Simó Schwartz; Diego Arango; Markus Makinen; Lauri A Aaltonen
Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis.
Oncogene 2007;26(2):312-20.
2006: Heli J Lehtonen; Maija Kiuru; Sanna K Ylisaukko-oja; Reijo Salovaara; Riitta Herva; Pasi A Koivisto; Outi Vierimaa; Kristiina Aittomäki; Eero Pukkala; Virpi Launonen; Lauri A Aaltonen
Increased risk of cancer in patients with fumarate hydratase germline mutation.
Journal of medical genetics 2006;43(6):523-6.
2006: Tuija Hienonen; Reijo Salovaara; Jukka-Pekka Mecklin; Heikki Järvinen; Auli Karhu; Lauri A Aaltonen
Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers.
International journal of cancer. Journal international du cancer 2006;118(2):505-8.
2005: Pia Alhopuro; Hafid Alazzouzi; Heli Sammalkorpi; Verónica Dávalos; Reijo Salovaara; Akseli Hemminki; Heikki Järvinen; Jukka-Pekka Mecklin; Simo Schwartz; Lauri A Aaltonen; Diego Arango
SMAD4 levels and response to 5-fluorouracil in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6311-6.
2005: Diego Arango; Päivi Laiho; Antti Kokko; Pia Alhopuro; Heli Sammalkorpi; Reijo Salovaara; Daniel Nicorici; Sampsa Hautaniemi; Hafid Alazzouzi; Jukka-Pekka Mecklin; Heikki Järvinen; Akseli Hemminki; Jaakko Astola; Simo Schwartz; Lauri A Aaltonen
Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer.
Gastroenterology 2005;129(3):874-84.
2005: Mogens Kruhøffer; Jens Ledet Jensen; Päivi Laiho; Lars Dyrskjøt; Reijo Salovaara; Diego Arango; Karin Birkenkamp-Demtroder; Flemming Brandt Sørensen; Lise Lotte Christensen; L Buhl; Jukka-Pekka Mecklin; Heikki Järvinen; Thomas Thykjaer; Friedrik P Wikman; F Bech-Knudsen; M Juhola; Nina N Nupponen; Søren Laurberg; Claus L Andersen; Lauri A Aaltonen; Torben F Ørntoft
Gene expression signatures for colorectal cancer microsatellite status and HNPCC.
British journal of cancer 2005;92(12):2240-8.
2005: Tuija Hienonen; Heli Sammalkorpi; Susa Enholm; Pia Alhopuro; Thomas D Barber; Rainer Lehtonen; Nina N Nupponen; Heli J Lehtonen; Reijo Salovaara; Jukka-Pekka Mecklin; Heikki Järvinen; Riitta Koistinen; Diego Arango; Virpi Launonen; Bert Vogelstein; Auli Karhu; Lauri A Aaltonen
Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers.
Cancer research 2005;65(11):4607-13.
2005: Hafid Alazzouzi; Pia Alhopuro; Reijo Salovaara; Heli Sammalkorpi; Heikki Järvinen; Jukka-Pekka Mecklin; Akseli Hemminki; Simo Schwartz; Lauri A Aaltonen; Diego Arango
SMAD4 as a prognostic marker in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(7):2606-11.
2004: Peter Calabrese; Jen-Lan Tsao; Yasushi Yatabe; Reijo Salovaara; Jukka-Pekka Mecklin; Heikki J Järvinen; Lauri A Aaltonen; Simon Tavaré; Darryl Shibata
Colorectal pretumor progression before and after loss of DNA mismatch repair.
The American journal of pathology 2004;164(4):1447-53.
2004: Eeva Kettunen; Sisko Anttila; Jouni K Seppänen; Antti Karjalainen; Henrik Edgren; Irmeli Lindström; Reijo Salovaara; Anna-Maria Nissén; Jarmo Salo; Karin Mattson; Jaakko Hollmén; Sakari Knuutila; Harriet Wikman
Differentially expressed genes in nonsmall cell lung cancer: expression profiling of cancer-related genes in squamous cell lung cancer.
Cancer genetics and cytogenetics 2004;149(2):98-106.
2004: Rainer Lehtonen; Maija Kiuru; Sakari Vanharanta; Jari Sjöberg; Leena-Maija Aaltonen; Kristiina Aittomäki; Johanna Arola; Ralf Butzow; Charis Eng; Kirsti Husgafvel-Pursiainen; Jorma Isola; Heikki Järvinen; Pasi A Koivisto; Jukka-Pekka Mecklin; Päivi Peltomäki; Reijo Salovaara; Veli-Matti Wasenius; Auli Karhu; Virpi Launonen; Nina N Nupponen; Lauri A Aaltonen
Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors.
The American journal of pathology 2004;164(1):17-22.
2003: Elise Renkonen; Yange Zhang; Hannes Lohi; Reijo Salovaara; Wael M Abdel-Rahman; Mef Nilbert; Kristiina Aittomaki; Heikki J Jarvinen; Jukka-Pekka Mecklin; Annika Lindblom; Paivi Peltomaki
Altered expression of MLH1, MSH2, and MSH6 in predisposition to hereditary nonpolyposis colorectal cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(19):3629-37.
2003: Tuija Hienonen; Päivi Laiho; Reijo Salovaara; Jukka-Pekka Mecklin; Heikki Järvinen; Pertti Sistonen; Päivi Peltomäki; Rainer Lehtonen; Nina N Nupponen; Virpi Launonen; Auli Karhu; Lauri A Aaltonen
Little evidence for involvement of MLH3 in colorectal cancer predisposition.
International journal of cancer. Journal international du cancer 2003;106(2):292-6.
2003: Päivi Laiho; Tuija Hienonen; Auli Karhu; Lara Lipton; Yan Aalto; Huw J W Thomas; Karin Birkenkamp-Demtroder; Shirley Hodgson; Reijo Salovaara; Jukka-Pekka Mecklin; Heikki Järvinen; Sakari Knuutila; Stephanie Halford; Torben F Ørntoft; Ian Tomlinson; Virpi Launonen; richard Houlston; Lauri A Aaltonen
Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial cases.
Oncogene 2003;22(14):2206-14.
2002: Derrick J Rossi; Antti Ylikorkala; Nina Korsisaari; Reijo Salovaara; Keijo Luukko; Virpi Launonen; Mark Henkemeyer; Ari Ristimaki; Lauri A Aaltonen; Tomi P Makela
Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12327-32.
2002: Maija Kiuru; Rainer Lehtonen; Johanna Arola; Reijo Salovaara; Heikki Järvinen; Kristiina Aittomäki; Jari Sjöberg; Tapio Visakorpi; Sakari Knuutila; Jorma Isola; Brett Delahunt; Riitta Herva; Virpi Launonen; Auli Karhu; Lauri A Aaltonen
Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families.
Cancer research 2002;62(16):4554-7.
2002: Xiao-Ping Zhou; Anu Loukola; Reijo Salovaara; Minna Nystrom-Lahti; Päivi Peltomäki; Albert de La Chapelle; Lauri A Aaltonen; Charis Eng
PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers.
The American journal of pathology 2002;161(2):439-47.
2002: Reijo Salovaara; S Roth; Anu Loukola; Virpi Launonen; Pertti Sistonen; E Avizienyte; Paula Kristo; Heikki Järvinen; S Souchelnytskyi; Maarit Sarlomo-Rikala; Lauri A Aaltonen
Frequent loss of SMAD4/DPC4 protein in colorectal cancers.
Gut 2002;51(1):56-9.
2002: Shannon Kuismanen; Anu-Liisa Moisio; Pascal Schweizer; Kaspar Truninger; Reijo Salovaara; Johanna Arola; Ralf Butzow; Josef Jiricny; Minna Nyström-Lahti; Päivi Peltomäki
Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability.
The American journal of pathology 2002;160(6):1953-8.
2002: Kyoung-Mee Kim; Reijo Salovaara; Jukka-Pekka Mecklin; Heikki J Järvinen; Lauri A Aaltonen; Darryl Shibata
PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper.
The American journal of pathology 2002;160(4):1503-6.
2001: Hidewaki Nakagawa; Gerard J Nuovo; Emmanuel E Zervos; Edward W Martin; Reijo Salovaara; Lauri A Aaltonen; Albert de La Chapelle
Age-related hypermethylation of the 5' region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development.
Cancer research 2001;61(19):6991-5.
2001: Xiao-Ping Zhou; Kelly Woodford-Richens; Rainer Lehtonen; K Kurose; Micheala A Aldred; Heather Hampel; Virpi Launonen; S Virta; Robert Pilarski; Reijo Salovaara; Walter F Bodmer; B A Conrad; M Dunlop; Shirley V Hodgson; T Iwama; Heikki Järvinen; Ilmo Kellokumpu; J C Kim; B Leggett; D Markie; Jukka-Pekka Mecklin; Kay Neale; Robin Phillips; Juan Piris; P Rozen; richard Houlston; Lauri A Aaltonen; Ian P M Tomlinson; Charis Eng
Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes.
American journal of human genetics 2001;69(4):704-11.
2001: Maija Kiuru; Virpi Launonen; Marja Hietala; Kristiina Aittomäki; Outi Vierimaa; Reijo Salovaara; Johanna Arola; Eero Pukkala; Pertti Sistonen; Riitta Herva; Lauri A Aaltonen
Familial cutaneous leiomyomatosis is a two-hit condition associated with renal cell cancer of characteristic histopathology.
The American journal of pathology 2001;159(3):825-9.
2001: Heini Lassus; Reijo Salovaara; Lauri A Aaltonen; Ralf Butzow
Allelic analysis of serous ovarian carcinoma reveals two putative tumor suppressor loci at 18q22-q23 distal to SMAD4, SMAD2, and DCC.
The American journal of pathology 2001;159(1):35-42.
2001: Anu Loukola; K Eklin; Päivi Laiho; Reijo Salovaara; Paula Kristo; Heikki Järvinen; Jukka-Pekka Mecklin; Virpi Launonen; Lauri A Aaltonen
Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC).
Cancer research 2001;61(11):4545-9.
2001: Pascal Schweizer; Anu-Liisa Moisio; Shannon Kuismanen; Kaspar Truninger; R Vierumäki; Reijo Salovaara; Johanna Arola; Ralf Butzow; Josef Jiricny; Päivi Peltomäki; Minna Nyström-Lahti
Lack of MSH2 and MSH6 characterizes endometrial but not colon carcinomas in hereditary nonpolyposis colorectal cancer.
Cancer research 2001;61(7):2813-5.
2001: E Avizienyte; Virpi Launonen; Reijo Salovaara; T Kiviluoto; Lauri A Aaltonen
E-cadherin is not frequently mutated in hereditary gastric cancer.
Journal of medical genetics 2001;38(1):49-52.
2000: S Roth; Päivi Laiho; Reijo Salovaara; Virpi Launonen; Lauri A Aaltonen
No SMAD4 hypermethylation in colorectal cancer.
British journal of cancer 2000;83(8):1015-9.
2000: Reijo Salovaara; Anu Loukola; Paula Kristo; Helena Kääriäinen; H Ahtola; Matti Eskelinen; N Härkönen; Risto Julkunen; E Kangas; S Ojala; J Tulikoura; E Valkamo; Heikki Järvinen; Jukka-Pekka Mecklin; Lauri A Aaltonen; Albert de La Chapelle
Population-based molecular detection of hereditary nonpolyposis colorectal cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(11):2193-200.
2000: Shannon Kuismanen; MT Holmberg; Reijo Salovaara; Albert de La Chapelle; Päivi Peltomäki
Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers.
The American journal of pathology 2000;156(5):1773-9.
2000: Virpi Launonen; E Avizienyte; Anu Loukola; Päivi Laiho; Reijo Salovaara; Heikki Järvinen; Jukka-Pekka Mecklin; A Oku; Miyuki Shimane; H C Kim; J C Kim; Jun-ichi Nezu; Lauri A Aaltonen
No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas.
Cancer research 2000;60(3):546-8.
2000: Jen-Lan Tsao; Yasushi Yatabe; Reijo Salovaara; Heikki J Järvinen; Jukka-Pekka Mecklin; Lauri A Aaltonen; Simon Tavaré; Darryl Shibata
Genetic reconstruction of individual colorectal tumor histories.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1236-41.
1999: Anu Loukola; Reijo Salovaara; Paula Kristo; Anu-Liisa Moisio; Helena Kääriäinen; H Ahtola; Matti Eskelinen; N Härkönen; Risto Julkunen; E Kangas; S Ojala; J Tulikoura; E Valkamo; Heikki Järvinen; Jukka-Pekka Mecklin; Albert de La Chapelle; Lauri A Aaltonen
Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer.
The American journal of pathology 1999;155(6):1849-53.
1999: Minna Nyström-Lahti; MT Holmberg; P Fidalgo; Reijo Salovaara; Albert de La Chapelle; Josef Jiricny; Päivi Peltomäki
Missense and nonsense mutations in codon 659 of MLH1 cause aberrant splicing of messenger RNA in HNPCC kindreds.
Genes, chromosomes & cancer 1999;26(4):372-5.
1999: A Riccio; Lauri A Aaltonen; A K Godwin; Anu Loukola; Antonio Percesepe; Reijo Salovaara; Valeria Masciullo; Maurizio Genuardi; M Paravatou-Petsotas; Daniel E Bassi; B A Ruggeri; Andres Klein-Szanto; J R Testa; Giovanni Neri; Alfonso Bellacosa
The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability.
Nature genetics 1999;23(3):266-8.
1999: Shannon Kuismanen; MT Holmberg; Reijo Salovaara; Pascal Schweizer; Lauri A Aaltonen; Albert de La Chapelle; Minna Nyström-Lahti; Päivi Peltomäki
Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12661-6.
1999: S Roth; Pertti Sistonen; Reijo Salovaara; Akseli Hemminki; Anu Loukola; M Johansson; E Avizienyte; K A Cleary; P Lynch; C I Amos; Paula Kristo; Jukka-Pekka Mecklin; Ilmo Kellokumpu; Heikki Järvinen; Lauri A Aaltonen
SMAD genes in juvenile polyposis.
Genes, chromosomes & cancer 1999;26(1):54-61.
1999: Jen-Lan Tsao; Simon Tavaré; Reijo Salovaara; J R Jass; Lauri A Aaltonen; Darryl Shibata
Colorectal adenoma and cancer divergence. Evidence of multilineage progression.
The American journal of pathology 1999;154(6):1815-24.
1999: Markku T Aarnio; Risto Sankila; Eero Pukkala; Reijo Salovaara; Lauri A Aaltonen; Albert de La Chapelle; Päivi Peltomäki; Jukka-Pekka Mecklin; Heikki J Järvinen
Cancer risk in mutation carriers of DNA-mismatch-repair genes.
International journal of cancer. Journal international du cancer 1999;81(2):214-8.
1999: E Avizienyte; Anu Loukola; S Roth; Akseli Hemminki; Maija Tarkkanen; Reijo Salovaara; Johanna Arola; Ralf Bützow; Kirsti Husgafvel-Pursiainen; Arto Kokkola; Heikki Järvinen; Lauri A Aaltonen
LKB1 somatic mutations in sporadic tumors.
The American journal of pathology 1999;154(3):677-81.
1998: Jen-Lan Tsao; J Zhang; Reijo Salovaara; Z H Li; Heikki J Järvinen; Jukka-Pekka Mecklin; Lauri A Aaltonen; Darryl Shibata
Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture.
The American journal of pathology 1998;153(4):1189-200.
1998: Marcelo L Larramendy; Wa'el El-Rifai; Arto Kokkola; Pauli Puolakkainen; Outi Monni; Reijo Salovaara; Markku T Aarnio; Sakari Knuutila
Comparative genomic hybridization reveals differences in DNA copy number changes between sporadic gastric carcinomas and gastric carcinomas from patients with hereditary nonpolyposis colorectal cancer.
Cancer genetics and cytogenetics 1998;106(1):62-5.
1998: Lauri A Aaltonen; Reijo Salovaara; Paula Kristo; F Canzian; Akseli Hemminki; Päivi Peltomäki; R B Chadwick; Helena Kääriäinen; Matti Eskelinen; Heikki Järvinen; Jukka-Pekka Mecklin; Albert de La Chapelle
Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease.
The New England journal of medicine 1998;338(21):1481-7.
1998: E Avizienyte; S Roth; Anu Loukola; Akseli Hemminki; Ragnhild A Lothe; Anna E Stenwig; Sophie D Fosså; Reijo Salovaara; Lauri A Aaltonen
Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors.
Cancer research 1998;58(10):2087-90.
1998: A Hemminki; P Höglund; Eero Pukkala; Reijo Salovaara; Heikki Järvinen; Reijo Norio; Lauri A Aaltonen
Intestinal cancer in patients with a germline mutation in the down-regulated in adenoma (DRA) gene.
Oncogene 1998;16(5):681-4.
1998: Akseli Hemminki; D Markie; Ian Tomlinson; E Avizienyte; S Roth; Anu Loukola; Graham R Bignell; William Warren; M Aminoff; Pia Höglund; Heikki Järvinen; Paula Kristo; Katarina Pelin; Maaret Ridanpää; Reijo Salovaara; T Toro; Walter Bodmer; S Olschwang; A S Olsen; Michael R Stratton; Albert de La Chapelle; Lauri A Aaltonen
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.
Nature 1998;391(6663):184-7.
1997: Markku T Aarnio; Reijo Salovaara; Lauri A Aaltonen; Jukka-Pekka Mecklin; Heikki J Järvinen
Features of gastric cancer in hereditary non-polyposis colorectal cancer syndrome.
International journal of cancer. Journal international du cancer 1997;74(5):551-5.
1997: Akseli Hemminki; Ian Tomlinson; D Markie; Heikki Järvinen; Pertti Sistonen; AM Björkqvist; Sakari Knuutila; Reijo Salovaara; Walter Bodmer; D Shibata; Albert de La Chapelle; Lauri A Aaltonen
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis.
Nature genetics 1997;15(1):87-90.
1996: F Canzian; Reijo Salovaara; Akseli Hemminki; Paula Kristo; R B Chadwick; Lauri A Aaltonen; Albert de La Chapelle
Semiautomated assessment of loss of heterozygosity and replication error in tumors.
Cancer research 1996;56(14):3331-7.
1996: Darryl Shibata; William Navidi; Reijo Salovaara; Z H Li; Lauri A Aaltonen
Somatic microsatellite mutations as molecular tumor clocks.
Nature medicine 1996;2(6):676-81.
1996: Z H Li; Reijo Salovaara; Lauri A Aaltonen; Darryl Shibata
Telomerase activity is commonly detected in hereditary nonpolyposis colorectal cancers.
The American journal of pathology 1996;148(4):1075-9.
1994: Akseli Hemminki; Päivi Peltomäki; Jukka-Pekka Mecklin; Heikki Järvinen; Reijo Salovaara; Minna Nyström-Lahti; Albert de La Chapelle; Lauri A Aaltonen
Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer.
Nature genetics 1994;8(4):405-10.