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Severo Salvadori

Research Profile

Chemicals & Drugs

Concepts & Ideas

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Genes & Molecular Sequences

Amino Acid Sequences

Anatomy

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TOP 3
Giordano Lesma; Teresa Recca; Alessandro Sacchetti; Severo Salvadori; Francesco Airaghi; Gianfranco Balboni; Engin Bojnik; Anna Borsodi; Alessandra Silvani
Synthesis, pharmacological evaluation and conformational investigation of endomorphin-2 hybrid analogues.
Xiaozhou He; Xuezhi Kang; Dong H Kim; Meredith L Moore; Severo Salvadori; Rong Wang; Gianfranco Balboni; Dongman Chao; Yilin Yang; Feng Zhi; Ying Xia
δ-Opioid Receptor Activation Modified MicroRNA Expression in the Rat Kidney under Prolonged Hypoxia.
Dongman Chao; Xiaozhou He; Dong H Kim; Severo Salvadori; Gianfranco Balboni; Yilin Yang; Ying Xia
Hydrogen sulfide induced disruption of Na+ homeostasis in the cortex.

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All Publications

2013: Giordano Lesma; Teresa Recca; Alessandro Sacchetti; Severo Salvadori; Francesco Airaghi; Gianfranco Balboni; Engin Bojnik; Anna Borsodi; Alessandra Silvani
Synthesis, pharmacological evaluation and conformational investigation of endomorphin-2 hybrid analogues.
Molecular diversity 2013;17(1):19-31.
2013: Xiaozhou He; Xuezhi Kang; Dong H Kim; Meredith L Moore; Severo Salvadori; Rong Wang; Gianfranco Balboni; Dongman Chao; Yilin Yang; Feng Zhi; Ying Xia
δ-Opioid Receptor Activation Modified MicroRNA Expression in the Rat Kidney under Prolonged Hypoxia.
PloS one 2013;8(4):e61080.
2012: Dongman Chao; Xiaozhou He; Dong H Kim; Severo Salvadori; Gianfranco Balboni; Yilin Yang; Ying Xia
Hydrogen sulfide induced disruption of Na+ homeostasis in the cortex.
Toxicological sciences : an official journal of the Society of Toxicology 2012;128(1):198-208.
2012: C Ruzza; Severo Salvadori; Giovanni Vitale; Valeria Camarda; Monica Filaferro; Remo Guerrini; Erika Marzola; Giuliano Marzola; C Novi; A Pulga; Anna Rizzi; Valentina Ruggieri; Girolamo Calo'
[tBu-D-Gly5]NPS, a pure and potent antagonist of the neuropeptide S receptor: in vitro and in vivo studies.
Peptides 2012;34(2):404-11.
2011: Girolamo Calo'; Carlo Cifani; David G Lambert; Maurizio Massi; Maria Vittoria Micioni Di Bonaventura; Domenico Regoli; Anna Rizzi; Severo Salvadori; Remo Guerrini
UFP-112 a potent and long-lasting agonist selective for the Nociceptin/Orphanin FQ receptor.
CNS neuroscience & therapeutics 2011;17(3):178-98.
2011: Claudio Trapella; Michela Pela; Luisa Del Zoppo; Girolamo Calo; Valeria Camarda; Chiara Ruzza; Alberto Cavazzini; Valentina Costa; Valerio Bertolasi; Rainer K Reinscheid; Severo Salvadori; Remo Guerrini
Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68).
Journal of medicinal chemistry 2011;54(8):2738-44.
2011: Orit Jacobson; Ido D Weiss; Gang Niu; Gianfranco Balboni; Cenzo Congiu; Valentina Onnis; Dale O Kiesewetter; Roberta Lattanzi; Severo Salvadori; Xiaoyuan Chen
Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011;52(4):600-7.
2011: Tetsuya Kushikata; Hitoshi Yoshida; Mihoko Kudo; Severo Salvadori; Girolamo Calo; Kazuyoshi Hirota
The effects of neuropeptide S on general anesthesia in rats.
Anesthesia and analgesia 2011;112(4):845-9.
2011: Gianfranco Balboni; Severo Salvadori; Ewa D Marczak; Brian I Knapp; Jean M Bidlack; Lawrence H Lazarus; Xuemei Peng; Yu Gui Si; John L Neumeyer
Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic.
European journal of medicinal chemistry 2011;46(2):799-803.
2010: Dianella Savoia; Manuela Donalisio; Andrea Civra; Severo Salvadori; Remo Guerrini
In vitro activity of dermaseptin S1 derivatives against genital pathogens.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2010;118(9):674-80.
2010: Remo Guerrini; Severo Salvadori; Anna Rizzi; Domenico Regoli; Girolamo Calo'
Neurobiology, pharmacology, and medicinal chemistry of neuropeptide S and its receptor.
Medicinal research reviews 2010;30(5):751-77.
2010: Gianfranco Balboni; Erika Marzola; Yusuke Sasaki; Akihiro Ambo; Ewa D Marczak; Lawrence H Lazarus; Severo Salvadori
Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds.
Bioorganic & medicinal chemistry 2010;18(16):6024-30.
2010: Chiara Ruzza; Anna Rizzi; Claudio Trapella; Michela Pela'; Valeria Camarda; Valentina Ruggieri; Monica Filaferro; Carlo Cifani; Rainer K Reinscheid; Giovanni Vitale; Roberto Ciccocioppo; Severo Salvadori; Remo Guerrini; Girolamo Calo'
Further studies on the pharmacological profile of the neuropeptide S receptor antagonist SHA 68.
Peptides 2010;31(5):915-25.
2010: Steven Ballet; Ewa D Marczak; Debby Feytens; Severo Salvadori; Yusuke Sasaki; Andrew D Abell; Lawrence H Lazarus; Gianfranco Balboni; Dirk Tourwé
Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.
Bioorganic & medicinal chemistry letters 2010;20(5):1610-3.
2009: O S Mabrouk; Matteo Marti; Severo Salvadori; Michele Morari
The novel delta opioid receptor agonist UFP-512 dually modulates motor activity in hemiparkinsonian rats via control of the nigro-thalamic pathway.
Neuroscience 2009;164(2):360-9.
2009: Gianfranco Balboni; Claudio Trapella; Yusuke Sasaki; Akihiro Ambo; Ewa D Marczak; Lawrence H Lazarus; Severo Salvadori
Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore.
Journal of medicinal chemistry 2009;52(17):5556-9.
2009: Elisa Giannini; Roberta Lattanzi; Annalisa Nicotra; Antonio F Campese; Paola Grazioli; Isabella Screpanti; Gianfranco Balboni; Severo Salvadori; Paola Sacerdote; Lucia Negri
The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(34):14646-51.
2009: Ewa D Marczak; Yunden Jinsmaa; Page H Myers; Terry Blankenship; Ralph Wilson; Gianfranco Balboni; Severo Salvadori; Lawrence H Lazarus
Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent mu/delta-opioid receptor antagonist, regulates obese-related factors in mice.
European journal of pharmacology 2009;616(1-3):115-21.
2009: Claudio Trapella; Carmela Fischetti; Michela Pela'; Ilaria Lazzari; Remo Guerrini; Girolamo Calo'; Anna Rizzi; Valeria Camarda; David G Lambert; John McDonald; Domenico Regoli; Severo Salvadori
Structure-activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide.
Bioorganic & medicinal chemistry 2009;17(14):5080-95.
2009: Remo Guerrini; Valeria Camarda; Claudio Trapella; Girolamo Caló; Anna Rizzi; Chiara Ruzza; Stella Fiorini; Erika Marzola; Rainer K Reinscheid; Domenico Regoli; Severo Salvadori
Further studies at neuropeptide s position 5: discovery of novel neuropeptide S receptor antagonists.
Journal of medicinal chemistry 2009;52(13):4068-71.
2009: Carmela Fischetti; Valeria Camarda; Anna Rizzi; Michela Pelà; Claudio Trapella; Remo Guerrini; John McDonald; David G Lambert; Severo Salvadori; Domenico Regoli; Girolamo Calo'
Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24.
European journal of pharmacology 2009;614(1-3):50-7.
2009: Madura Batuwangala; Valeria Camarda; John McDonald; Erika Marzola; David G Lambert; Leong L Ng; Girolamo Calo'; Domenico Regoli; Claudio Trapella; Remo Guerrini; Severo Salvadori
Structure-activity relationship study on Tyr9 of urotensin-II(4-11): identification of a partial agonist of the UT receptor.
Peptides 2009;30(6):1130-6.
2009: Valeria Camarda; Anna Rizzi; Chiara Ruzza; Silvia Zucchini; Giuliano Marzola; Erika Marzola; Remo Guerrini; Severo Salvadori; Rainer K Reinscheid; Domenico Regoli; Girolamo Calò
In vitro and in vivo pharmacological characterization of the neuropeptide s receptor antagonist [D-Cys(tBu)5]neuropeptide S.
The Journal of pharmacology and experimental therapeutics 2009;328(2):549-55.
2009: Remo Guerrini; Valeria Camarda; Claudio Trapella; Girolamo Calò; Anna Rizzi; Chiara Ruzza; Stella Fiorini; Erika Marzola; Rainer K Reinscheid; Domenico Regoli; Severo Salvadori
Synthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonists.
Journal of medicinal chemistry 2009;52(2):524-9.
2009: Steven Ballet; Debby Feytens; Rien De Wachter; Magali De Vlaeminck; Ewa D Marczak; Severo Salvadori; Chris de Graaf; Didier Rognan; Lucia Negri; Roberta Lattanzi; Lawrence H Lazarus; Dirk Tourwé; Gianfranco Balboni
Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.
Bioorganic & medicinal chemistry letters 2009;19(2):433-7.
2008: Gianfranco Balboni; Ilaria Lazzari; Claudio Trapella; Lucia Negri; Roberta Lattanzi; Elisa Giannini; Annalisa Nicotra; Pietro Melchiorri; Sergio Visentin; Chiara De Nuccio; Severo Salvadori
Triazine compounds as antagonists at Bv8-prokineticin receptors.
Journal of medicinal chemistry 2008;51(23):7635-9.
2008: Valeria Camarda; Claudio Trapella; Girolamo Calo'; Remo Guerrini; Anna Rizzi; Chiara Ruzza; Stella Fiorini; Erika Marzola; Rainer K Reinscheid; Domenico Regoli; Severo Salvadori
Structure-activity study at positions 3 and 4 of human neuropeptide S.
Bioorganic & medicinal chemistry 2008;16(19):8841-5.
2008: Yunden Jinsmaa; Ewa D Marczak; Gianfranco Balboni; Severo Salvadori; Lawrence H Lazarus
Inhibition of the development of morphine tolerance by a potent dual mu-delta-opioid antagonist, H-Dmt-Tic-Lys-NH-CH2-Ph.
Pharmacology, biochemistry, and behavior 2008;90(4):651-7.
2008: Dianella Savoia; Remo Guerrini; Erika Marzola; Severo Salvadori
Synthesis and antimicrobial activity of dermaseptin S1 analogues.
Bioorganic & medicinal chemistry 2008;16(17):8205-9.
2008: Dongman Chao; Alia Bazzy-Asaad; Gianfranco Balboni; Severo Salvadori; Ying Xia
Activation of DOR attenuates anoxic K+ derangement via inhibition of Na+ entry in mouse cortex.
Cerebral cortex (New York, N.Y. : 1991) 2008;18(9):2217-27.
2008: Gianfranco Balboni; Stella Fiorini; Anna Baldisserotto; Claudio Trapella; Yusuke Sasaki; Akihiro Ambo; Ewa D Marczak; Lawrence H Lazarus; Severo Salvadori
Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.
Journal of medicinal chemistry 2008;51(16):5109-17.
2008: Anna Rizzi; Raffaella Vergura; Giuliano Marzola; C Ruzza; Remo Guerrini; Severo Salvadori; Domenico Regoli; Girolamo Calo
Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice.
British journal of pharmacology 2008;154(2):471-9.
2008: Erika Marzola; Valeria Camarda; Madura Batuwangala; David G Lambert; Girolamo Calo'; Remo Guerrini; Claudio Trapella; Domenico Regoli; Roberto Tomatis; Severo Salvadori
Structure-activity relationship study of position 4 in the urotensin-II receptor ligand U-II(4-11).
Peptides 2008;29(5):674-9.
2008: Eun Kyoung Ryu; Zhanhong Wu; kai chen; Lawrence H Lazarus; Ewa D Marczak; Yusuke Sasaki; Akihiro Ambo; Severo Salvadori; Chuancheng Ren; Heng Zhao; Gianfranco Balboni; Xiaoyuan Chen
Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging.
Journal of medicinal chemistry 2008;51(6):1817-23.
2008: Severo Salvadori; Stella Fiorini; Claudio Trapella; Frank Porreca; Peg Davis; Yusuke Sasaki; Akihiro Ambo; Ewa D Marczak; Lawrence H Lazarus; Gianfranco Balboni
Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502).
Bioorganic & medicinal chemistry 2008;16(6):3032-8.
2008: Valeria Camarda; Claudio Trapella; Girolamo Calo; Remo Guerrini; Anna Rizzi; Chiara Ruzza; Stella Fiorini; Erika Marzola; Rainer K Reinscheid; Domenico Regoli; Severo Salvadori
Synthesis and biological activity of human neuropeptide S analogues modified in position 2.
Journal of medicinal chemistry 2008;51(3):655-8.
2008: Raffaella Vergura; Gianfranco Balboni; Barbara Spagnolo; Elaine Gavioli; David G Lambert; John McDonald; Claudio Trapella; Lawrence H Lazarus; Domenico Regoli; Remo Guerrini; Severo Salvadori; Girolamo Caló
Anxiolytic- and antidepressant-like activities of H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), a novel selective delta opioid receptor agonist.
Peptides 2008;29(1):93-103.
2007: Severo Salvadori; Claudio Trapella; Stella Fiorini; Lucia Negri; Roberta Lattanzi; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Gianfranco Balboni
A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic.
Bioorganic & medicinal chemistry 2007;15(22):6876-81.
2007: Teodorico Tancredi; Remo Guerrini; Erika Marzola; Claudio Trapella; Girolamo Calo; Domenico Regoli; Rainer K Reinscheid; Valeria Camarda; Severo Salvadori; Piero A Temussi
Conformation-activity relationship of neuropeptide S and some structural mutants: helicity affects their interaction with the receptor.
Journal of medicinal chemistry 2007;50(18):4501-8.
2007: Marika Arduin; Barbara Spagnolo; Girolamo Calò; Remo Guerrini; Giacomo Carrà; Carmela Fischetti; Claudio Trapella; Erika Marzola; John McDonald; David G Lambert; Domenico Regoli; Severo Salvadori
Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha,alpha-dialkylated amino acids.
Bioorganic & medicinal chemistry 2007;15(13):4434-43.
2007: Anna Rizzi; Barbara Spagnolo; Richard D Wainford; Carmela Fischetti; Remo Guerrini; Giuliano Marzola; Anna Baldisserotto; Severo Salvadori; Domenico Regoli; Daniel R Kapusta; Girolamo Calo
In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor.
Peptides 2007;28(6):1240-51.
2007: Annalisa Pastore; Severo Salvadori; Piero A Temussi
Peptides and proteins in a confined environment: NMR spectra at natural isotopic abundance.
Journal of peptide science : an official publication of the European Peptide Society 2007;13(5):342-7.
2007: Gianfranco Balboni; Valentina Onnis; Cenzo Congiu; Margherita Zotti; Yusuke Sasaki; Akihiro Ambo; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Ilaria Lazzari; Claudio Trapella; Severo Salvadori
Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore.
Bioorganic & medicinal chemistry 2007;15(9):3143-51.
2007: Cristiano Nazzaro; Anna Rizzi; Severo Salvadori; Remo Guerrini; Domenico Regoli; Hanns Ulrich Zeilhofer; Girolamo Calo
UFP-101 antagonizes the spinal antinociceptive effects of nociceptin/orphanin FQ: behavioral and electrophysiological studies in mice.
Peptides 2007;28(3):663-9.
2006: Raffaella Vergura; Elena Valenti; Christopher P Hebbes; Elaine Gavioli; Barbara Spagnolo; John McDonald; David G Lambert; Gianfranco Balboni; Severo Salvadori; Domenico Regoli; Girolamo Calo'
Dmt-Tic-NH-CH2-Bid (UFP-502), a potent DOP receptor agonist: in vitro and in vivo studies.
Peptides 2006;27(12):3322-30.
2006: Massimo Lazzeri; Girolamo Calò; Michele Spinelli; Silvia Malaguti; Remo Guerrini; Severo Salvadori; Patrizia Beneforti; Domenico Regoli; Damiano Turini
Daily intravesical instillation of 1 mg nociceptin/orphanin FQ for the control of neurogenic detrusor overactivity: a multicenter, placebo controlled, randomized exploratory study.
The Journal of urology 2006;176(5):2098-102.
2006: John L Neumeyer; Xuemei Peng; Brian I Knapp; Jean M Bidlack; Lawrence H Lazarus; Severo Salvadori; Claudio Trapella; Gianfranco Balboni
New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.
Journal of medicinal chemistry 2006;49(18):5640-3.
2006: Gianfranco Balboni; Valentina Onnis; Cenzo Congiu; Margherita Zotti; Yusuke Sasaki; Akihiro Ambo; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Claudio Trapella; Severo Salvadori
Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.
Journal of medicinal chemistry 2006;49(18):5610-7.
2006: Adelheid L Roth; Erika Marzola; Anna Rizzi; Marika Arduin; Claudio Trapella; Corrado Corti; Raffaella Vergura; Prisca Martinelli; Severo Salvadori; Domenico Regoli; Mauro Corsi; Paolo Cavanni; Girolamo Caló; Remo Guerrini
Structure-activity studies on neuropeptide S: identification of the amino acid residues crucial for receptor activation.
The Journal of biological chemistry 2006;281(30):20809-16.
2006: Steven Ballet; Severo Salvadori; Claudio Trapella; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Lucia Negri; Elisa Giannini; Roberta Lattanzi; Dirk Tourwé; Gianfranco Balboni
New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands.
Journal of medicinal chemistry 2006;49(13):3990-3.
2006: M. Eugenio Vázquez; Juan B Blanco; Severo Salvadori; Claudio Trapella; Roberto Argazzi; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Lucia Negri; Elisa Giannini; Roberta Lattanzi; Mariantonella Colucci; Gianfranco Balboni
6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.
Journal of medicinal chemistry 2006;49(12):3653-8.
2006: Claudio Trapella; Remo Guerrini; Laura Piccagli; Girolamo Calo'; Giacomo Carra'; Barbara Spagnolo; Samantha Rubini; Giulia Fanton; Christopher P Hebbes; John McDonald; David G Lambert; Domenico Regoli; Severo Salvadori
Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist.
Bioorganic & medicinal chemistry 2006;14(3):692-704.
2006: Valeria Camarda; Martina Spagnol; Wei Song; Raffaella Vergura; Adelheid L Roth; Jonathan P Thompson; David J Rowbotham; Remo Guerrini; Erika Marzola; Severo Salvadori; Paolo Cavanni; Domenico Regoli; Stephen Douglas; David G Lambert; Girolamo Calò
In vitro and in vivo pharmacological characterization of the novel UT receptor ligand [Pen5,DTrp7,Dab8]urotensin II(4-11) (UFP-803).
British journal of pharmacology 2006;147(1):92-100.
2005: Gianfranco Balboni; Remo Guerrini; Severo Salvadori; Lucia Negri; Elisa Giannini; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus
Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).
Journal of medicinal chemistry 2005;48(26):8112-4.
2005: Tingyou Li; Yoshio Fujita; Kimitaka Shiotani; Anna Miyazaki; Yuko Tsuda; Akihiro Ambo; Yusuke Sasaki; Yunden Jinsmaa; Ewa Marczak; Sharon D Bryant; Severo Salvadori; Lawrence H Lazarus; Yoshio Okada
Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists.
Journal of medicinal chemistry 2005;48(25):8035-44.
2005: Matteo Marti; Flora Mela; Martina Fantin; Silvia Zucchini; Jeffrey M Brown; Jassir Witta; Manuela Di Benedetto; Beata Buzas; Rainer K Reinscheid; Severo Salvadori; Remo Guerrini; Patrizia Romualdi; Sanzio Candeletti; Michele Simonato; Brian M Cox; Michele Morari
Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(42):9591-601.
2005: Gianfranco Balboni; Maria Teresa Cocco; Severo Salvadori; Romeo Romagnoli; Yusuke Sasaki; Yoshio Okada; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus
From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH.
Journal of medicinal chemistry 2005;48(17):5608-11.
2005: Giacomo Carra'; Girolamo Calo'; Barbara Spagnolo; Remo Guerrini; Marika Arduin; Erika Marzola; Claudio Trapella; Domenico Regoli; Severo Salvadori
Tryptophan replacement in the nociceptin/orphanin FQ receptor ligand Ac-RYYRWK-NH2.
The journal of peptide research : official journal of the American Peptide Society 2005;66(1):39-47.
2005: Nicola Marchetti; Francesco Dondi; attila felinger; Remo Guerrini; Severo Salvadori; Alberto Cavazzini
Modeling of overloaded gradient elution of nociceptin/orphanin FQ in reversed-phase liquid chromatography.
Journal of chromatography. A 2005;1079(1-2):162-72.
2005: Teodorico Tancredi; Giacomo Carrà; Remo Guerrini; Marika Arduin; Girolamo Calò; Domenico Regoli; Severo Salvadori; Piero A Temussi
The interaction of highly helical structural mutants with the NOP receptor discloses the role of the address domain of nociceptin/orphanin FQ.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(7):2061-70.
2005: Remo Guerrini; Girolamo Caló; David G Lambert; Giacomo Carrá; Marika Arduin; Timothy A Barnes; John McDonald; Daniela Rizzi; Claudio Trapella; Erika Marzola; David J Rowbotham; Domenico Regoli; Severo Salvadori
N- and C-terminal modifications of nociceptin/orphanin FQ generate highly potent NOP receptor ligands.
Journal of medicinal chemistry 2005;48(5):1421-7.
2005: Giacomo Carrà; Anna Rizzi; Remo Guerrini; Timothy A Barnes; John McDonald; Christopher P Hebbes; Flora Mela; Velga A Kenigs; Giuliano Marzola; Daniela Rizzi; Elaine Gavioli; Silvia Zucchini; Domenico Regoli; Michele Morari; Severo Salvadori; David J Rowbotham; David G Lambert; Daniel R Kapusta; Girolamo Calo'
[(pF)Phe4,Arg14,Lys15]N/OFQ-NH2 (UFP-102), a highly potent and selective agonist of the nociceptin/orphanin FQ receptor.
The Journal of pharmacology and experimental therapeutics 2005;312(3):1114-23.
2005: Remo Guerrini; Valeria Camarda; Erika Marzola; Marika Arduin; Girolamo Calo; Martina Spagnol; Anna Rizzi; Severo Salvadori; Domenico Regoli
Structure-activity relationship study on human urotensin II.
Journal of peptide science : an official publication of the European Peptide Society 2005;11(2):85-90.
2005: Girolamo Calo; Remo Guerrini; Anna Rizzi; Severo Salvadori; Melissa A Burmeister; Daniel R Kapusta; David G Lambert; Domenico Regoli
UFP-101, a peptide antagonist selective for the nociceptin/orphanin FQ receptor.
CNS drug reviews 2005;11(2):97-112.
2004: Gianfranco Balboni; Severo Salvadori; Alessandro Dal Piaz; Fabrizio Bortolotti; Roberto Argazzi; Lucia Negri; Roberta Lattanzi; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus
Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic.
Journal of medicinal chemistry 2004;47(26):6541-6.
2004: Stephen Martin; Rodolfo R Biekofsky; Murray A Skinner; Remo Guerrini; Severo Salvadori; James Feeney; Peter M Bayley
Interaction of calmodulin with the phosphofructokinase target sequence.
FEBS letters 2004;577(1-2):284-8.
2004: Raffaella Vergura; Valeria Camarda; Anna Rizzi; Martina Spagnol; Remo Guerrini; Girolamo Calo'; Severo Salvadori; Domenico Regoli
Urotensin II stimulates plasma extravasation in mice via UT receptor activation.
Naunyn-Schmiedeberg's archives of pharmacology 2004;370(5):347-52.
2004: Valeria Camarda; Wei Song; Erika Marzola; Martina Spagnol; Remo Guerrini; Severo Salvadori; Domenico Regoli; Jonathan P Thompson; David J Rowbotham; David J Behm; Stephen Douglas; Girolamo Calo'; David G Lambert
Urantide mimics urotensin-II induced calcium release in cells expressing recombinant UT receptors.
European journal of pharmacology 2004;498(1-3):83-6.
2004: Anna Maria D'Ursi; Maria Rosaria Armenante; Remo Guerrini; Severo Salvadori; Giuseppe Sorrentino; Delia Picone
Solution structure of amyloid beta-peptide (25-35) in different media.
Journal of medicinal chemistry 2004;47(17):4231-8.
2004: Gianfranco Balboni; Severo Salvadori; Remo Guerrini; Lucia Negri; Elisa Giannini; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus
Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism.
Journal of medicinal chemistry 2004;47(16):4066-71.
2004: Matteo Marti; Flora Mela; Carlo Veronesi; Remo Guerrini; Severo Salvadori; Mauro Federici; Nicola B Mercuri; Anna Rizzi; Gianfranco Franchi; Lorenzo Beani; Clementina Bianchi; Michele Morari
Blockade of nociceptin/orphanin FQ receptor signaling in rat substantia nigra pars reticulata stimulates nigrostriatal dopaminergic transmission and motor behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(30):6659-66.
2004: Elaine Gavioli; Christopher W Vaughan; Giuliano Marzola; Remo Guerrini; V A Mitchell; Silvia Zucchini; Thereza C M De Lima; Giles A Rae; Severo Salvadori; Domenico Regoli; Girolamo Calo'
Antidepressant-like effects of the nociceptin/orphanin FQ receptor antagonist UFP-101: new evidence from rats and mice.
Naunyn-Schmiedeberg's archives of pharmacology 2004;369(6):547-53.
2004: Remo Guerrini; Giacomo Carra'; Girolamo Calo'; Claudio Trapella; Erika Marzola; Daniela Rizzi; Domenico Regoli; Severo Salvadori
Nonpeptide/peptide chimeric ligands for the nociceptin/orphanin FQ receptor: design, synthesis and in vitro pharmacological activity.
The journal of peptide research : official journal of the American Peptide Society 2004;63(6):477-84.
2004: Teodorico Tancredi; Annalisa Pastore; Severo Salvadori; Veronica Esposito; Piero A Temussi
Interaction of sweet proteins with their receptor. A conformational study of peptides corresponding to loops of brazzein, monellin and thaumatin.
European journal of biochemistry / FEBS 2004;271(11):2231-40.
2004: Flora Mela; Matteo Marti; Linda Ulazzi; Elvis Vaccari; Silvia Zucchini; Claudio Trapella; Severo Salvadori; Lorenzo Beani; Clementina Bianchi; Michele Morari
Pharmacological profile of nociceptin/orphanin FQ receptors regulating 5-hydroxytryptamine release in the mouse neocortex.
The European journal of neuroscience 2004;19(5):1317-24.
2004: Severo Salvadori; Piero A Temussi
Antagonism in opioid peptides: the role of conformation.
Current topics in medicinal chemistry 2004;4(1):145-57.
2003: Gianfranco Balboni; Severo Salvadori; Remo Guerrini; Lucia Negri; Elisa Giannini; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus
Synthesis and opioid activity of N,N-dimethyl-Dmt-Tic-NH-CH(R)-R' analogues: acquisition of potent delta antagonism.
Bioorganic & medicinal chemistry 2003;11(24):5435-41.
2003: Yoshio Okada; Yuko Tsuda; Yoshio Fujita; Toshio Yokoi; Yusuke Sasaki; Akihiro Ambo; Ryoji Konishi; Mitsuhiro Nagata; Severo Salvadori; Yunden Jinsmaa; Sharon D Bryant; Lawrence H Lazarus
Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia.
Journal of medicinal chemistry 2003;46(15):3201-9.
2003: Kimmo Ingman; Severo Salvadori; Larry Lazarus; Esa R Korpi; Aapo Honkanen
Selective delta-opioid receptor antagonist N,N(CH3)2-Dmt-Tic-OH does not reduce ethanol intake in alcohol-preferring AA rats.
Addiction biology 2003;8(2):173-9.
2003: Elaine Gavioli; Giuliano Marzola; Remo Guerrini; R Bertorelli; Silvia Zucchini; Thereza C M De Lima; Giles A Rae; Severo Salvadori; Domenico Regoli; Girolamo Calo
Blockade of nociceptin/orphanin FQ-NOP receptor signalling produces antidepressant-like effects: pharmacological and genetic evidences from the mouse forced swimming test.
The European journal of neuroscience 2003;17(9):1987-90.
2003: Michele Tognetto; Michael R D'Andrea; Marcello Trevisani; Remo Guerrini; Severo Salvadori; Lorella Spisani; Carlo Daniele; Patricia Andrade-Gordon; Pierangelo Geppetti; Selena Harrison
Proteinase-activated receptor-1 (PAR-1) activation contracts the isolated human renal artery in vitro.
British journal of pharmacology 2003;139(1):21-7.
2003: Massimo Lazzeri; Girolamo Calò; Michele Spinelli; Remo Guerrini; Severo Salvadori; Patrizia Beneforti; Sandro Sandri; Domenico Regoli; Damiano Turini
Urodynamic effects of intravesical nociceptin/orphanin FQ in neurogenic detrusor overactivity: a randomized, placebo-controlled, double-blind study.
Urology 2003;61(5):946-50.
2003: Remo Guerrini; Daniela Rizzi; Marina Zucchini; Roberto Tomatis; Domenico Regoli; Girolamo Calo'; Severo Salvadori
Nociceptin/Orphanin FQ(1-13)NH2 analogues modified in the Phe1-Gly2 peptide bond.
Bioorganic & medicinal chemistry letters 2003;13(3):365-8.
2003: Sharon D Bryant; Yunden Jinsmaa; Severo Salvadori; Yoshio Okada; Lawrence H Lazarus
Dmt and opioid peptides: a potent alliance.
Biopolymers 2003;71(2):86-102.
2002: Gianfranco Balboni; Severo Salvadori; Remo Guerrini; Lucia Negri; Elisa Giannini; Yunden Jinsmaa; Sharon D Bryant; Lawrence H Lazarus
Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.
Journal of medicinal chemistry 2002;45(25):5556-63.
2002: Sharon D Bryant; Clifford George; Judith L Flippen-Anderson; Jeffrey Deschamps; Severo Salvadori; Gianfranco Balboni; Remo Guerrini; Lawrence H Lazarus
Crystal structures of dipeptides containing the Dmt-Tic pharmacophore.
Journal of medicinal chemistry 2002;45(25):5506-13.
2002: Orlando Crescenzi; Simona Tomaselli; Remo Guerrini; Severo Salvadori; Anna Maria D'Ursi; Piero A Temussi; Delia Picone
Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain.
European journal of biochemistry / FEBS 2002;269(22):5642-8.
2002: Valeria Camarda; Remo Guerrini; Evi Kostenis; Anna Rizzi; Girolamo Calò; Almut Hattenberger; Marina Zucchini; Severo Salvadori; Domenico Regoli
A new ligand for the urotensin II receptor.
British journal of pharmacology 2002;137(3):311-4.
2002: Pietro Amodeo; Remo Guerrini; Delia Picone; Severo Salvadori; Roberta Spadaccini; Teodorico Tancredi; Piero A Temussi
Solution structure of nociceptin peptides.
Journal of peptide science : an official publication of the European Peptide Society 2002;8(9):497-509.
2002: Valeria Camarda; Anna Rizzi; Girolamo Calo; Remo Guerrini; Severo Salvadori; Domenico Regoli
Pharmacological profile of hemokinin 1: a novel member of the tachykinin family.
Life sciences 2002;71(4):363-70.
2002: Anna Rizzi; Maria Bonaria Salis; Roberto Ciccocioppo; Giuliano Marzola; Raffaella Bigoni; Remo Guerrini; Maurizio Massi; Paolo Madeddu; Severo Salvadori; Domenico Regoli; Girolamo Calo'
Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)NH2 analogues. 2. In vivo studies.
Naunyn-Schmiedeberg's archives of pharmacology 2002;365(6):450-6.
2002: Raffaella Bigoni; Daniela Rizzi; Anna Rizzi; Valeria Camarda; Remo Guerrini; David G Lambert; Eiji Hashiba; Hartmut Berger; Severo Salvadori; Domenico Regoli; Girolamo Calo'
Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. In vitro studies.
Naunyn-Schmiedeberg's archives of pharmacology 2002;365(6):442-9.
2002: Cinzia Severini; Giovanna Improta; Giuliana Falconieri-Erspamer; Severo Salvadori; Vittorio Erspamer
The tachykinin peptide family.
Pharmacological reviews 2002;54(2):285-322.
2002: Girolamo Calo; Anna Rizzi; Daniela Rizzi; Raffaella Bigoni; Remo Guerrini; Giuliano Marzola; Matteo Marti; John McDonald; Michele Morari; David G Lambert; Severo Salvadori; Domenico Regoli
[Nphe1,Arg14,Lys15]nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor.
British journal of pharmacology 2002;136(2):303-11.
2002: Girolamo Calo'; Anna Rizzi; Raffaella Bigoni; Remo Guerrini; Severo Salvadori; Domenico Regoli
Pharmacological profile of nociceptin/orphanin FQ receptors.
Clinical and experimental pharmacology & physiology 2002;29(3):223-8.
2002: Anastasia S Politou; Roberta Spadaccini; Catherine Joseph; Barbara Brannetti; Remo Guerrini; Manuela Helmer-Citterich; Severo Salvadori; Piero A Temussi; Annalisa Pastore
The SH3 domain of nebulin binds selectively to type II peptides: theoretical prediction and experimental validation.
Journal of molecular biology 2002;316(2):305-15.
2002: Gianfranco Balboni; Remo Guerrini; Severo Salvadori; Clementina Bianchi; Daniela Rizzi; Sharon D Bryant; Lawrence H Lazarus
Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.
Journal of medicinal chemistry 2002;45(3):713-20.
2002: Roberto Ciccocioppo; Carlo Polidori; Lorena Antonelli; Severo Salvadori; Remo Guerrini; Maurizio Massi
Pharmacological characterization of the nociceptin receptor which mediates reduction of alcohol drinking in rats.
Peptides 2002;23(1):117-25.
2001: Amalia Di Giannuario; A Rizzi; Stefano Pieretti; Remo Guerrini; R Bertorelli; Severo Salvadori; Domenico Regoli; Girolamo Calo
Studies on the antinociceptive effect of [Nphe1]nociceptin(1-13)NH2 in mice.
Neuroscience letters 2001;316(1):25-8.
2001: Remo Guerrini; Girolamo Caló; Raffaella Bigoni; Daniela Rizzi; Anna Rizzi; M Zucchini; Katia Varani; Eiji Hashiba; David G Lambert; Géza Toth; Pier Andrea Borea; Severo Salvadori; Domenico Regoli
Structure-activity studies of the Phe(4) residue of nociceptin(1-13)-NH(2): identification of highly potent agonists of the nociceptin/orphanin FQ receptor.
Journal of medicinal chemistry 2001;44(23):3956-64.
2001: Anna Rizzi; Giuliano Marzola; Raffaella Bigoni; Remo Guerrini; Severo Salvadori; J S Mogil; Domenico Regoli; Girolamo Calò
Endogenous nociceptin signaling and stress-induced analgesia.
Neuroreport 2001;12(14):3009-13.
2001: Vincenzo Santagada; Giuseppe Caliendo; Beatrice Severino; Elisa Perissutti; Francesca Ceccarelli; Laura Giusti; Maria R Mazzoni; Severo Salvadori; Piero A Temussi
Probing the shape of a hydrophobic pocket in the active site of delta-opioid antagonists.
Journal of peptide science : an official publication of the European Peptide Society 2001;7(7):374-85.
2001: T Lovekamp; PS Cooper; J Hardison; Sharon D Bryant; Remo Guerrini; Gianfranco Balboni; Severo Salvadori; Lawrence H Lazarus
Inhibition of human multidrug resistance P-glycoprotein 1 by analogues of a potent delta-opioid antagonist.
Brain research 2001;902(1):131-4.
2001: Mauro Marastoni; Martina Bazzaro; Severo Salvadori; Federica Bortolotti; Roberto Tomatis
HIV-1 protease inhibitors containing an N-hydroxyamino acid core structure.
Bioorganic & medicinal chemistry 2001;9(4):939-45.
2001: Remo Guerrini; Girolamo Calo'; Raffaella Bigoni; Daniela Rizzi; Domenico Regoli; Severo Salvadori
Structure-activity relationship of [Nphe1]-NC-(1-13)-NH2, a pure and selective nociceptin/orphanin FQ receptor antagonist.
The journal of peptide research : official journal of the American Peptide Society 2001;57(3):215-22.
2001: Anna Rizzi; Raffaella Bigoni; Giuliano Marzola; Remo Guerrini; Severo Salvadori; Domenico Regoli; Girolamo Calo'
Characterization of the locomotor activity-inhibiting effect of nociceptin/orphanin FQ in mice.
Naunyn-Schmiedeberg's archives of pharmacology 2001;363(2):161-5.
2000: Vincenzo Santagada; Gianfranco Balboni; Giuseppe Caliendo; Remo Guerrini; Severo Salvadori; C Bianchi; Sharon D Bryant; Lawrence H Lazarus
Assessment of substitution in the second pharmacophore of Dmt-Tic analogues.
Bioorganic & medicinal chemistry letters 2000;10(24):2745-8.
2000: Gianfranco Balboni; Severo Salvadori; Remo Guerrini; C Bianchi; Vincenzo Santagada; G Calliendo; Sharon D Bryant; Lawrence H Lazarus
Opioid pseudopeptides containing heteroaromatic or heteroaliphatic nuclei.
Peptides 2000;21(11):1663-71.
2000: Cinzia Severini; Severo Salvadori; R Guerrini; Giuliana Falconieri-Erspamer; Giuseppina Mignogna; Vittorio Erspamer
Parallel bioassay of 39 tachykinins on 11 smooth muscle preparations. Structure and receptor selectivity/affinity relationship.
Peptides 2000;21(11):1587-95.
2000: Anna Rizzi; Raffaella Bigoni; Giuliano Marzola; Remo Guerrini; Severo Salvadori; Domenico Regoli; Girolamo Calo
The nociceptin/orphanin FQ receptor antagonist, [Nphe1]NC(1-13)NH2, potentiates morphine analgesia.
Neuroreport 2000;11(11):2369-72.
2000: Remo Guerrini; Girolamo Caló; Raffaella Bigoni; Anna Rizzi; Katia Varani; Géza Toth; Stefania Gessi; Eiji Hashiba; Y Hashimoto; David G Lambert; Pier Andrea Borea; Roberto Tomatis; Severo Salvadori; Domenico Regoli
Further studies on nociceptin-related peptides: discovery of a new chemical template with antagonist activity on the nociceptin receptor.
Journal of medicinal chemistry 2000;43(15):2805-13.
2000: Girolamo Calo'; Raffaella Bigoni; Anna Rizzi; Remo Guerrini; Severo Salvadori; Domenico Regoli
Nociceptin/orphanin FQ receptor ligands.
Peptides 2000;21(7):935-47.
2000: Remo Guerrini; Girolamo Calo'; Anna Rizzi; Raffaella Bigoni; Daniela Rizzi; Domenico Regoli; Severo Salvadori
Structure-activity relationships of nociceptin and related peptides: comparison with dynorphin A.
Peptides 2000;21(7):923-33.
2000: Fabio L M Ricciardolo; Martin Steinhoff; Silvia Amadesi; Remo Guerrini; Michele Tognetto; Marcello Trevisani; Christophe Creminon; C Bertrand; Nigel W Bunnett; Leonardo M Fabbri; Severo Salvadori; Pierangelo Geppetti
Presence and bronchomotor activity of protease-activated receptor-2 in guinea pig airways.
American journal of respiratory and critical care medicine 2000;161(5):1672-80.
2000: Girolamo Calo'; Remo Guerrini; Anna Rizzi; Severo Salvadori; Domenico Regoli
Pharmacology of nociceptin and its receptor: a novel therapeutic target.
British journal of pharmacology 2000;129(7):1261-83.
2000: Girolamo Calo'; Remo Guerrini; Raffaella Bigoni; Anna Rizzi; Giuliano Marzola; H Okawa; Clementina Bianchi; David G Lambert; Severo Salvadori; Domenico Regoli
Characterization of [Nphe(1)]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist.
British journal of pharmacology 2000;129(6):1183-93.
2000: Orlando Crescenzi; Remo Guerrini; Delia Picone; Severo Salvadori; Teodorico Tancredi; Piero A Temussi
Solution structure of nocistatin, a new peptide analgesic.
Biopolymers 2000;53(3):257-64.
1999: Anna Rizzi; Raffaella Bigoni; Girolamo Caló; Remo Guerrini; Severo Salvadori; Domenico Regoli
[Nphe(1)]nociceptin-(1-13)-NH(2) antagonizes nociceptin effects in the mouse colon.
European journal of pharmacology 1999;385(2-3):R3-5.
1999: Severo Salvadori; Remo Guerrini; Gianfranco Balboni; Clementina Bianchi; Sharon D Bryant; PS Cooper; Lawrence H Lazarus
Further studies on the Dmt-Tic pharmacophore: hydrophobic substituents at the C-terminus endow delta antagonists to manifest mu agonism or mu antagonism.
Journal of medicinal chemistry 1999;42(24):5010-9.
1999: Severo Salvadori; Remo Guerrini; Girolamo Calo; Domenico Regoli
Structure-activity studies on nociceptin/orphanin FQ: from full agonist, to partial agonist, to pure antagonist.
Farmaco (Società chimica italiana : 1989) 1999;54(11-12):810-25.
1999: Katia Varani; Anna Rizzi; Girolamo Calo; Raffaella Bigoni; Géza Toth; Remo Guerrini; Stefania Gessi; Severo Salvadori; Pier Andrea Borea; Domenico Regoli
Pharmacology of [Tyr1]nociceptin analogs: receptor binding and bioassay studies.
Naunyn-Schmiedeberg's archives of pharmacology 1999;360(3):270-7.
1999: Mauro Marastoni; Martina Bazzaro; Federica Bortolotti; Severo Salvadori; Roberto Tomatis
Symmetry-based inhibitors of HIV-1 protease. Design, synthesis and preliminary structure-activity studies of acylated 2,3-diamino-1-hydroxypropanes and 2,4 diamino-1-hydroxybutanes.
European journal of medicinal chemistry 1999;34(7-8):651-7.
1999: Lucia Negri; Roberta Lattanzi; Anna Borsodi; G Toth; Severo Salvadori
Differential knockdown of delta-opioid receptor subtypes in the rat brain by antisense oligodeoxynucleotides targeting mRNA.
Antisense & nucleic acid drug development 1999;9(2):203-11.
1999: Raffaella Bigoni; Sandro Giuliani; Girolamo Calo'; Anna Rizzi; Remo Guerrini; Severo Salvadori; Domenico Regoli; C A Maggi
Characterization of nociceptin receptors in the periphery: in vitro and in vivo studies.
Naunyn-Schmiedeberg's archives of pharmacology 1999;359(3):160-7.
1999: Lawrence H Lazarus; Sharon D Bryant; PS Cooper; Severo Salvadori
What peptides these deltorphins be.
Progress in neurobiology 1999;57(4):377-420.
1999: Anna Rizzi; Girolamo Calò; Marcello Trevisani; Michele Tognetto; L Fabbri; Cristina E Mapp; Remo Guerrini; Severo Salvadori; Domenico Regoli; Pierangelo Geppetti
Nociceptin receptor activation inhibits tachykinergic non adrenergic non cholinergic contraction of guinea pig isolated bronchus.
Life sciences 1999;64(13):PL157-63.
1999: Mauro Marastoni; Remo Guerrini; Gianfranco Balboni; Severo Salvadori; Giancarlo Fantin; Marco Fogagnolo; Lawrence H Lazarus; Roberto Tomatis
Opioid deltorphin C analogues containing cis- or trans-2- or 3- or 4-aminocyclohexanecarboxylic acid residues.
Arzneimittel-Forschung 1999;49(1):6-12.
1998: Katia Varani; Girolamo Calo; Anna Rizzi; Stefania Merighi; Géza Toth; Remo Guerrini; Severo Salvadori; Pier Andrea Borea; Domenico Regoli
Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships.
British journal of pharmacology 1998;125(7):1485-90.
1998: Girolamo Calò; Anna Rizzi; Giuliano Marzola; Remo Guerrini; Severo Salvadori; Lorenzo Beani; Domenico Regoli; Clementina Bianchi
Pharmacological characterization of the nociceptin receptor mediating hyperalgesia in the mouse tail withdrawal assay.
British journal of pharmacology 1998;125(2):373-8.
1998: Girolamo Calo'; Remo Guerrini; Raffaella Bigoni; Anna Rizzi; Clementina Bianchi; Domenico Regoli; Severo Salvadori
Structure-activity study of the nociceptin(1-13)-NH2 N-terminal tetrapeptide and discovery of a nociceptin receptor antagonist.
Journal of medicinal chemistry 1998;41(18):3360-6.
1998: Mauro Marastoni; Federica Bortolotti; Severo Salvadori; Roberto Tomatis
Structure-activity relationships of HIV-1 protease inhibitors containing gem-diaminoserine core unit.
Arzneimittel-Forschung 1998;48(6):709-12.
1998: Sharon D Bryant; Severo Salvadori; PS Cooper; Lawrence H Lazarus
New delta-opioid antagonists as pharmacological probes.
Trends in pharmacological sciences 1998;19(2):42-6.
1998: Remo Guerrini; Anna Capasso; Mauro Marastoni; Sharon D Bryant; PS Cooper; Lawrence H Lazarus; Piero A Temussi; Severo Salvadori
Rational design of dynorphin A analogues with delta-receptor selectivity and antagonism for delta- and kappa-receptors.
Bioorganic & medicinal chemistry 1998;6(1):57-62.
1998: Remo Guerrini; Girolamo Calo; Anna Rizzi; Raffaella Bigoni; Clementina Bianchi; Severo Salvadori; Domenico Regoli
A new selective antagonist of the nociceptin receptor.
British journal of pharmacology 1998;123(2):163-5.
1997: Anna Capasso; Pietro Amodeo; Gianfranco Balboni; Remo Guerrini; Lawrence H Lazarus; Piero A Temussi; Severo Salvadori
Design of mu selective opioid dipeptide antagonists.
FEBS letters 1997;417(1):141-4.
1997: Severo Salvadori; Gianfranco Balboni; Remo Guerrini; Roberto Tomatis; Clementina Bianchi; Sharon D Bryant; PS Cooper; Lawrence H Lazarus
Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.
Journal of medicinal chemistry 1997;40(19):3100-8.
1997: Roberto Tomatis; Mauro Marastoni; Gianfranco Balboni; Remo Guerrini; Anna Capasso; Ludovico Sorrentino; Vincenzo Santagada; G Caliendo; Lawrence H Lazarus; Severo Salvadori
Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.
Journal of medicinal chemistry 1997;40(18):2948-52.
1997: Sharon D Bryant; Remo Guerrini; Severo Salvadori; C Bianchi; Roberto Tomatis; M Attila; Lawrence H Lazarus
Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues.
Journal of medicinal chemistry 1997;40(16):2579-87.
1997: Orlando Crescenzi; Franca Fraternali; Delia Picone; Teodorico Tancredi; Gianfranco Balboni; Remo Guerrini; Lawrence H Lazarus; Severo Salvadori; Piero A Temussi
Design and solution structure of a partially rigid opioid antagonist lacking the basic center--models of antagonism.
European journal of biochemistry / FEBS 1997;247(1):66-73.
1997: Remo Guerrini; Girolamo Calo; Anna Rizzi; Clementina Bianchi; Lawrence H Lazarus; Severo Salvadori; Piero A Temussi; Domenico Regoli
Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin-(1-13)-peptide amide.
Journal of medicinal chemistry 1997;40(12):1789-93.
1997: Girolamo Calò; Anna Rizzi; M Bodin; W Neugebauer; Severo Salvadori; Remo Guerrini; Clementina Bianchi; Domenico Regoli
Pharmacological characterization of nociceptin receptor: an in vitro study.
Canadian journal of physiology and pharmacology 1997;75(6):713-8.
1997: Mauro Marastoni; Severo Salvadori; F Bortolotti; Roberto Tomatis
HIV-1 protease inhibitors containing a novel C2 symmetrical hydroxyalkylgem-diamino core structure.
The journal of peptide research : official journal of the American Peptide Society 1997;49(6):538-44.
1997: Severo Salvadori; Delia Picone; Teodorico Tancredi; Remo Guerrini; Roberta Spadaccini; Lawrence H Lazarus; D Regoli; Piero A Temussi
Solution conformation of nociceptin.
Biochemical and biophysical research communications 1997;233(3):640-3.
1997: Sharon D Bryant; Gianfranco Balboni; Remo Guerrini; Severo Salvadori; Roberto Tomatis; Lawrence H Lazarus
Opioid diketopiperazines: refinement of the delta opioid antagonist pharmacophore.
Biological chemistry 1997;378(2):107-14.
1997: Gianfranco Balboni; Remo Guerrini; Severo Salvadori; Roberto Tomatis; Sharon D Bryant; Clementina Bianchi; M Attila; Lawrence H Lazarus
Opioid diketopiperazines: synthesis and activity of a prototypic class of opioid antagonists.
Biological chemistry 1997;378(1):19-29.
1996: Girolamo Calò; Anna Rizzi; G Bogoni; V Neugebauer; Severo Salvadori; Remo Guerrini; Clementina Bianchi; D Regoli
The mouse vas deferens: a pharmacological preparation sensitive to nociceptin.
European journal of pharmacology 1996;311(1):R3-5.
1996: Orlando Crescenzi; Pietro Amodeo; G Cavicchioni; Remo Guerrini; Delia Picone; Severo Salvadori; Teodorico Tancredi; Piero A Temussi
Delta-selective opioid peptides containing a single aromatic residue in the message domain: an NMR conformational analysis.
Journal of peptide science : an official publication of the European Peptide Society 1996;2(5):290-308.
1996: Remo Guerrini; A Capasso; Ludovico Sorrentino; R Anacardio; Sharon D Bryant; Lawrence H Lazarus; M Attila; Severo Salvadori
Opioid receptor selectivity alteration by single residue replacement: synthesis and activity profile of [Dmt1]deltorphin B.
European journal of pharmacology 1996;302(1-3):37-42.
1996: A Breveglieri; Remo Guerrini; Severo Salvadori; Clementina Bianchi; Sharon D Bryant; M Attila; Lawrence H Lazarus
Design and synthesis of 1-aminocycloalkane-1-carboxylic acid-substituted deltorphin analogues: unique delta and mu opioid activity in modified peptides.
Journal of medicinal chemistry 1996;39(3):773-80.
1996: Lawrence H Lazarus; Sharon D Bryant; Severo Salvadori; M Attila; L Sargent Jones
Opioid infidelity: novel opioid peptides with dual high affinity for delta- and mu-receptors.
Trends in neurosciences 1996;19(1):31-5.
1996: A Capasso; Remo Guerrini; Gianfranco Balboni; Ludovico Sorrentino; Piero A Temussi; Lawrence H Lazarus; Sharon D Bryant; Severo Salvadori
Dmt-Tic-OH a highly selective and potent delta-opioid dipeptide receptor antagonist after systemic administration in the mouse.
Life sciences 1996;59(8):PL93-8.
1995: Pietro Amodeo; Gianfranco Balboni; Orlando Crescenzi; Remo Guerrini; Delia Picone; Severo Salvadori; Teodorico Tancredi; Piero A Temussi
Conformational analysis of potent and very selective delta opioid dipeptide antagonists.
FEBS letters 1995;377(3):363-7.
1995: Severo Salvadori; M Attila; Gianfranco Balboni; Clementina Bianchi; Sharon D Bryant; Orlando Crescenzi; Remo Guerrini; Delia Picone; Teodorico Tancredi; Piero A Temussi
Delta opioidmimetic antagonists: prototypes for designing a new generation of ultraselective opioid peptides.
Molecular medicine (Cambridge, Mass.) 1995;1(6):678-89.
1995: M R Ciajolo; Gianfranco Balboni; Delia Picone; Severo Salvadori; Teodorico Tancredi; Piero A Temussi; A Tuzi
Solution and solid-state structure of the diketopiperazine of tyrosyl-tetrahydroisoquinoline-3-carboxylic acid.
International journal of peptide and protein research 1995;46(2):134-8.
1995: Ettore C degli Uberti; Severo Salvadori; Giorgio Trasforini; Maria Rosaria Ambrosio; Angelo Margutti; Marta Bondanelli; Roberta Rossi; A Valentini
Differential effects of deltorphin on arginine and galanin-induced growth hormone secretion in healthy man.
Regulatory peptides 1995;58(1-2):41-6.
1995: S Capasso; Filomena Sica; Lelio Mazzarella; Gianfranco Balboni; Remo Guerrini; Severo Salvadori
Acid catalysis in the formation of dioxopiperazines from peptides containing tetrahydroisoquinoline-3-carboxylic acid at position 2.
International journal of peptide and protein research 1995;45(6):567-73.
1995: Gianfranco Balboni; Severo Salvadori; F D'Angeli; P Marchetti; Lawrence H Lazarus; Sharon D Bryant; Clementina Bianchi
Single diastereomeric desaminotyrosylalanyl tetra- and heptapeptides with opioid antagonistic activity.
International journal of peptide and protein research 1995;45(2):187-93.
1995: Mauro Marastoni; Severo Salvadori; Gianfranco Balboni; V Scaranari; Pier Andrea Borea; A Tomatis
Synthesis and opioid activity of tyrosine sulfate containing dermorphin and deltorphin peptides.
Arzneimittel-Forschung 1995;45(2):116-9.
1995: Ettore C degli Uberti; Felice Petraglia; Marta Bondanelli; A L Guo; A Valentini; Severo Salvadori; M Criscuolo; Rossella E Nappi; Andrea R Genazzani
Involvement of mu-opioid receptors in the modulation of pituitary-adrenal axis in normal and stressed rats.
Journal of endocrinological investigation 1995;18(1):1-7.
1994: Mauro Marastoni; Severo Salvadori; V Scaranari; Susanna Spisani; E Reali; Serena Traniello; A Tomatis
Synthesis and activity of new linear and cyclic peptide T derivatives.
Arzneimittel-Forschung 1994;44(9):1073-6.
1994: Teodorico Tancredi; Severo Salvadori; Pietro Amodeo; Delia Picone; Lawrence H Lazarus; Sharon D Bryant; Remo Guerrini; G Marzola; Piero A Temussi
Conversion of enkephalin and dermorphin into delta-selective opioid antagonists by single-residue substitution.
European journal of biochemistry / FEBS 1994;224(1):241-7.
1994: Lawrence H Lazarus; Sharon D Bryant; M Attila; Severo Salvadori
Frog skin opioid peptides: a case for environmental mimicry.
Environmental health perspectives 1994;102(8):648-54.
1994: Sharon D Bryant; M Attila; Severo Salvadori; Remo Guerrini; Lawrence H Lazarus
Molecular dynamics conformations of deltorphin analogues advocate delta opioid binding site models.
Peptide research 1994;7(4):175-84.
1994: Piero A Temussi; Severo Salvadori; Pietro Amodeo; C Bianchi; Remo Guerrini; Roberto Tomatis; Lawrence H Lazarus; Delia Picone; Teodorico Tancredi
Selective opioid dipeptides.
Biochemical and biophysical research communications 1994;198(3):933-9.
1993: Ettore C degli Uberti; Maria Rosaria Ambrosio; L Vergnani; Francesco Portaluppi; Marta Bondanelli; Giorgio Trasforini; Angelo Margutti; Severo Salvadori
Stress-induced activation of sympathetic nervous system is attenuated by the delta-opioid receptor agonist deltorphin in healthy man.
The Journal of clinical endocrinology and metabolism 1993;77(6):1490-4.
1993: M Attila; Severo Salvadori; Gianfranco Balboni; Sharon D Bryant; Lawrence H Lazarus
Synthesis and receptor binding analysis of dermorphin hepta-, hexa- and pentapeptide analogues. Evidence for one- and two-side binding models for the mu-opioid receptor.
International journal of peptide and protein research 1993;42(6):550-9.
1993: Severo Salvadori; Sharon D Bryant; Clementina Bianchi; Gianfranco Balboni; V Scaranari; M Attila; Lawrence H Lazarus
Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors.
Journal of medicinal chemistry 1993;36(24):3748-56.
1993: Mauro Marastoni; Severo Salvadori; Gianfranco Balboni; V Scaranari; Susanna Spisani; E Reali; Serena Traniello; Roberto Tomatis
Structure-activity relationships of cyclic and linear peptide T analogues.
International journal of peptide and protein research 1993;41(5):447-54.
1993: Giuliano Fontani; L Vergnani; Severo Salvadori; N Voglino; Anna Maria Aloisi; Francesco Portaluppi; Ettore C degli Uberti
Effect of deltorphin on behavior and hippocampal electrical activity in rabbits.
Physiology & behavior 1993;53(2):285-90.
1993: Severo Salvadori; Sharon D Bryant; Piero A Temussi; D M Bundy; M Attila; Roberto Tomatis; Lawrence H Lazarus
Relationship between receptor affinity and topography of N-terminally extended and bridged [Tyr1-->Asp4]deltorphin C analogues: novel probes for the delta-opioid receptor.
European journal of pharmacology 1993;230(3):357-61.
1993: Lawrence H Lazarus; Severo Salvadori; M Attila; P Grieco; D M Bundy; W E Wilson; Roberto Tomatis
Interaction of deltorphin with opioid receptors: molecular determinants for affinity and selectivity.
Peptides 1993;14(1):21-8.
1993: Giuliano Fontani; L Vergnani; Severo Salvadori; N Voglino; Anna Maria Aloisi; Francesco Portaluppi; Ettore C degli Uberti
Effect of dermorphin on behavior and hippocampal electrical activity in rabbits.
Life sciences 1993;52(3):323-8.
1992: Severo Salvadori; Clementina Bianchi; Lawrence H Lazarus; V Scaranari; M Attila; Roberto Tomatis
Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites.
Journal of medicinal chemistry 1992;35(25):4651-7.
1992: Ettore C degli Uberti; Severo Salvadori; Giorgio Trasforini; Angelo Margutti; Maria Rosaria Ambrosio; Roberta Rossi; Francesco Portaluppi; L Vergnani; R Pansini
delta-Opioid receptors and the secretion of growth hormone in man: effect of opioid delta-receptor agonist deltorphin on GH responses to GH-releasing hormone and insulin-induced hypoglycemia.
Neuroendocrinology 1992;56(6):907-12.
1992: Severo Salvadori; Remo Guerrini; Pier Andrea Borea; Roberto Tomatis
Synthesis and pharmacological activity of the N-terminal dermorphin tetrapeptide analogs with CH2-NH peptide bond isosteres.
International journal of peptide and protein research 1992;40(5):437-44.
1992: Ettore C degli Uberti; Severo Salvadori; Giorgio Trasforini; Angelo Margutti; Maria Rosaria Ambrosio; Roberta Rossi; Francesco Portaluppi; R Pansini
Effect of deltorphin on pituitary-adrenal response to insulin-induced hypoglycemia and ovine corticotropin-releasing hormone in healthy man.
The Journal of clinical endocrinology and metabolism 1992;75(2):370-4.
1992: Lawrence H Lazarus; Severo Salvadori; Gianfranco Balboni; Roberto Tomatis; W E Wilson
Stereospecificity of amino acid side chains in deltorphin defines binding to opioid receptors.
Journal of medicinal chemistry 1992;35(7):1222-7.
1992: Piero A Temussi; Delia Picone; Gabriella Saviano; Pietro Amodeo; Andrea Motta; Teodorico Tancredi; Severo Salvadori; Roberto Tomatis
Conformational analysis of an opioid peptide in solvent media that mimic cytoplasm viscosity.
Biopolymers 1992;32(4):367-72.
1992: Pietro Amodeo; Andrea Motta; Teodorico Tancredi; Severo Salvadori; Roberto Tomatis; Delia Picone; Gabriella Saviano; Piero A Temussi
Solution structure of deltorphin I at 265 K: a quantitative NMR study.
Peptide research 1992;5(1):48-55.
1991: Mauro Marastoni; V Scaranari; Severo Salvadori; Roberto Tomatis; Susanna Spisani; Serena Traniello
Synthesis and antiaggregatory activity of antiflammin related peptides.
Farmaco (Società chimica italiana : 1989) 1991;46(11):1265-72.
1991: Mauro Marastoni; Roberto Tomatis; Gianfranco Balboni; Severo Salvadori; Lawrence H Lazarus
On the degradation of the deltorphin peptides by plasma and brain homogenate.
Farmaco (Società chimica italiana : 1989) 1991;46(11):1273-9.
1991: Lawrence H Lazarus; Severo Salvadori; Roberto Tomatis; W E Wilson
Opioid receptor selectivity reversal in deltorphin tetrapeptide analogues.
Biochemical and biophysical research communications 1991;178(1):110-5.
1991: Teodorico Tancredi; Piero A Temussi; Delia Picone; Pietro Amodeo; Roberto Tomatis; Severo Salvadori; Mauro Marastoni; Vincenzo Santagada; Gianfranco Balboni
New insights on mu/delta selectivity of opioid peptides: conformational analysis of deltorphin analogues.
Biopolymers 1991;31(6):751-60.
1991: Severo Salvadori; Mauro Marastoni; Gianfranco Balboni; Pier Andrea Borea; Michele Morari; Roberto Tomatis
Synthesis and structure-activity relationships of deltorphin analogues.
Journal of medicinal chemistry 1991;34(5):1656-61.
1991: Lawrence H Lazarus; Severo Salvadori; Vincenzo Santagada; Roberto Tomatis; W E Wilson
Function of negative charge in the "address domain" of deltorphins.
Journal of medicinal chemistry 1991;34(4):1350-5.
1991: Mauro Marastoni; Severo Salvadori; Gianfranco Balboni; V Scaranari; Vincenzo Santagada; Patrizia Romualdi; S Ferri; Roberto Tomatis
Studies on the anti-phospholipase A2 and anti-inflammatory activities of a synthetic nonapeptide from uteroglobin.
Arzneimittel-Forschung 1991;41(3):240-3.
1990: Gianfranco Balboni; Mauro Marastoni; Delia Picone; Severo Salvadori; Teodorico Tancredi; Piero A Temussi; Roberto Tomatis
New features of the delta opioid receptor: conformational properties of deltorphin I analogues.
Biochemical and biophysical research communications 1990;169(2):617-22.
1990: Mauro Marastoni; Severo Salvadori; Gianfranco Balboni; Susanna Spisani; Riccardo Gavioli; Serena Traniello; Roberto Tomatis
Synthesis, metabolic stability and chemotactic activity of peptide T and its analogues.
International journal of peptide and protein research 1990;35(2):81-8.
1989: Mauro Marastoni; Gianfranco Balboni; Roberto Tomatis; Severo Salvadori; P A Borea; L Uccelli
Opioid peptides. Partially modified retro-inverso dermorphin analogues. XIII.
Farmaco (Società chimica italiana : 1989) 1989;44(11):1083-93.
1989: Mauro Marastoni; Severo Salvadori; Gianfranco Balboni; Susanna Spisani; Riccardo Gavioli; Serena Traniello; Roberto Tomatis
Structure-activity relationships of peptide T-related pentapeptides.
Arzneimittel-Forschung 1989;39(8):926-8.
1989: Mauro Marastoni; Severo Salvadori; Gianfranco Balboni; Pier Andrea Borea; Roberto Tomatis
Synthesis and activity of dermorphin-growth hormone releasing factor hybrid peptides.
Arzneimittel-Forschung 1989;39(6):639-41.
1989: Piero A Temussi; Delia Picone; Teodorico Tancredi; Roberto Tomatis; Severo Salvadori; Mauro Marastoni; Gianfranco Balboni
Conformational properties of deltorphin: new features of the delta-opioid receptor.
FEBS letters 1989;247(2):283-8.
1989: Severo Salvadori; Mauro Marastoni; Gianfranco Balboni; Pier Andrea Borea; Roberto Tomatis
Opioid peptides. Synthesis and binding properties of dermorphin related heptapeptides.
International journal of peptide and protein research 1989;33(2):94-102.
1989: M A Castiglione-Morelli; Gabriella Saviano; Piero A Temussi; Gianfranco Balboni; Severo Salvadori; Roberto Tomatis
NMR studies of a series of dehydrodermorphins.
Biopolymers 1989;28(1):129-38.
1988: M A Castiglione-Morelli; Teodorico Tancredi; E Trivellone; Gianfranco Balboni; Mauro Marastoni; Severo Salvadori; Roberto Tomatis; Piero A Temussi
Structure-activity relationship of tetrapeptides related to dermorphin: a 500-MHz 1H-nmr study.
Biopolymers 1988;27(9):1353-61.
1987: Severo Salvadori; Mauro Marastoni; Gianfranco Balboni; Roberto Tomatis; P A Borea
Opioid peptides. Synthesis and binding assays of desamino-Tyr1 dermorphin analogues. XII.
Il Farmaco; edizione scientifica 1987;42(12):931-40.
1987: M A Castiglione-Morelli; F Lelj; A Pastore; Severo Salvadori; Teodorico Tancredi; Roberto Tomatis; E Trivellone; Piero A Temussi
A 500-MHz proton nuclear magnetic resonance study of mu opioid peptides in a simulated receptor environment.
Journal of medicinal chemistry 1987;30(11):2067-73.