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Guy Salvesen
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28
Stennicke, Henning
19
Reed, John
12
Deveraux, Quinn
12
Denault, Jean-Bernard
11
Snipas, Scott
10
Riedl, Stefan
10
Scott, Fiona
10
Renatus, Martin
10
Dixit, Vishva
10
Mikolajczyk, Jowita
9
Bredesen, Dale
8
Ellerby, Lisa
8
Pop, Cristina
8
Shin, Hwain
7
Drag, Marcin
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All Publications
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2009: Timmer John C; Zhu Wenhong; Pop Cristina; Regan Tim; Snipas Scott J; Eroshkin Alexey M; Riedl Stefan J; Salvesen Guy S
Structural and kinetic determinants of protease substrates.
Nature structural & molecular biology 2009;16(10):1101-8.
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2009: Salvesen Guy S; Riedl Stefan J
Structure of the Fas/FADD complex: a conditional death domain complex mediating signaling by receptor clustering.
Cell cycle (Georgetown, Tex.) 2009;8(17):2723-7.
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2009: Pop Cristina; Salvesen Guy S
Human caspases: activation, specificity, and regulation.
The Journal of biological chemistry 2009;284(33):21777-81.
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2009: Békés Miklós; Salvesen Guy S
The CULt of caspase-8 ubiquitination.
Cell 2009;137(4):604-6.
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2009: Zhu Shanshan; Goeres Jacqueline; Sixt Katherine M; Békés Miklós; Zhang Xiang-Dong; Salvesen Guy S; Matunis Michael J
Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1.
Molecular cell 2009;33(5):570-80.
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2009: Scott Fiona L; Stec Boguslaw; Pop Cristina; Dobaczewska Malgorzata K; Lee JeongEun J; Monosov Edward; Robinson Howard; Salvesen Guy S; Schwarzenbacher Robert; Riedl Stefan J
The Fas-FADD death domain complex structure unravels signalling by receptor clustering.
Nature 2009;457(7232):1019-22.
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2008: Enoksson Mari; Salvesen Guy S
Proteolytic needles in the cellular haystack.
Nature chemical biology 2008;4(11):651-2.
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2008: Drag Marcin; Salvesen Guy S
DeSUMOylating enzymes--SENPs.
IUBMB life 2008;60(11):734-42.
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2008: Drag Marcin; Mikolajczyk Jowita; Bekes Miklos; Reyes-Turcu Francisca E; Ellman Jonathan A; Wilkinson Keith D; Salvesen Guy S
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes).
The Biochemical journal 2008;415(3):367-75.
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2008: Droga-Mazovec Gabriela; Bojic Lea; Petelin Ana; Ivanova Saska; Romih Rok; Repnik Urska; Salvesen Guy S; Stoka Veronika; Turk Vito; Turk Boris
Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues.
The Journal of biological chemistry 2008;283(27):19140-50.
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2008: Scott Fiona L; Fuchs Greg J; Boyd Sarah E; Denault Jean-Bernard; Hawkins Christine J; Dequiedt Franck; Salvesen Guy S
Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function.
The Journal of biological chemistry 2008;283(28):19499-510.
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2008: Snipas S J; Drag M; Stennicke H R; Salvesen G S
Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC.
Cell death and differentiation 2008;15(5):938-45.
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2008: Eckelman B P; Drag M; Snipas S J; Salvesen G S
The mechanism of peptide-binding specificity of IAP BIR domains.
Cell death and differentiation 2008;15(5):920-8.
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2008: Drag Marcin; Mikolajczyk Jowita; Krishnakumar I M; Huang Ziwei; Salvesen Guy S
Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family.
The Biochemical journal 2008;409(2):461-9.
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2008: Pop Cristina; Salvesen Guy S; Scott Fiona L
Caspase assays: identifying caspase activity and substrates in vitro and in vivo.
Methods in enzymology 2008;446():351-67.
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2008: Salvesen Guy S; Riedl Stefan J
Caspase mechanisms.
Advances in experimental medicine and biology 2008;615():13-23.
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2008: Denault Jean-Bernard; Salvesen Guy S
Apoptotic caspase activation and activity.
Methods in molecular biology (Clifton, N.J.) 2008;414():191-220.
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2007: Truscott Mary; Denault Jean-Bernard; Goulet Brigitte; Leduy Lam; Salvesen Guy S; Nepveu Alain
Carboxyl-terminal proteolytic processing of CUX1 by a caspase enables transcriptional activation in proliferating cells.
The Journal of biological chemistry 2007;282(41):30216-26.
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2007: Wu Yi I; Munshi Hidayatullah G; Snipas Scott J; Salvesen Guy S; Fridman Rafael; Stack M Sharon
Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking.
The Biochemical journal 2007;407(2):171-7.
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2007: Timmer John C; Enoksson Mari; Wildfang Eric; Zhu Wenhong; Igarashi Yoshinobu; Denault Jean-Benard; Ma Yuliang; Dummitt Benjamin; Chang Yie-Hwa; Mast Alan E; Eroshkin Alexey; Smith Jeffrey W; Tao W Andy; Salvesen Guy S
Profiling constitutive proteolytic events in vivo.
The Biochemical journal 2007;407(1):41-8.
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2007: Denault Jean-Bernard; Drag Marcin; Salvesen Guy S; Alves Juliano; Heidt Analeah B; Deveraux Quinn; Harris Jennifer L
Small molecules not direct activators of caspases.
Nature chemical biology 2007;3(9):519; author reply 520.
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2007: Mikolajczyk Jowita; Drag Marcin; Békés Miklós; Cao John T; Ronai Ze'ev; Salvesen Guy S
Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs.
The Journal of biological chemistry 2007;282(36):26217-24.
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2007: Enoksson Mari; Li Jingwei; Ivancic Melanie M; Timmer John C; Wildfang Eric; Eroshkin Alexey; Salvesen Guy S; Tao W Andy
Identification of proteolytic cleavage sites by quantitative proteomics.
Journal of proteome research 2007;6(7):2850-8.
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2007: Denault Jean-Bernard; Eckelman Brendan P; Shin Hwain; Pop Cristina; Salvesen Guy S
Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9.
The Biochemical journal 2007;405(1):11-9.
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2007: Salvesen Guy S; Riedl Stefan J
Caspase inhibition, specifically.
Structure (London, England : 1993) 2007;15(5):513-4.
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2007: Riedl Stefan J; Salvesen Guy S
The apoptosome: signalling platform of cell death.
Nature reviews. Molecular cell biology 2007;8(5):405-13.
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2007: Pop Cristina; Fitzgerald Patrick; Green Douglas R; Salvesen Guy S
Role of proteolysis in caspase-8 activation and stabilization.
Biochemistry 2007;46(14):4398-407.
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2006: Dobó József; Swanson Richard; Salvesen Guy S; Olson Steven T; Gettins Peter G W
Cytokine response modifier a inhibition of initiator caspases results in covalent complex formation and dissociation of the caspase tetramer.
The Journal of biological chemistry 2006;281(50):38781-90.
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2006: Eckelman Brendan P; Salvesen Guy S; Scott Fiona L
Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family.
EMBO reports 2006;7(10):988-94.
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2006: Ekici Ozlem Dogan; Li Zhao Zhao; Campbell Amy J; James Karen Ellis; Asgian Juliana L; Mikolajczyk Jowita; Salvesen Guy S; Ganesan Rajkumar; Jelakovic Stjepan; Grütter Markus G; Powers James C
Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10.
Journal of medicinal chemistry 2006;49(19):5728-49.
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2006: Denault Jean-Bernard; Békés Miklós; Scott Fiona L; Sexton Kelly M B; Bogyo Matthew; Salvesen Guy S
Engineered hybrid dimers: tracking the activation pathway of caspase-7.
Molecular cell 2006;23(4):523-33.
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2006: Berger Alicia B; Witte Martin D; Denault Jean-Bernard; Sadaghiani Amir Masoud; Sexton Kelly M B; Salvesen Guy S; Bogyo Matthew
Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes.
Molecular cell 2006;23(4):509-21.
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2006: Pop Cristina; Timmer John; Sperandio Sabina; Salvesen Guy S
The apoptosome activates caspase-9 by dimerization.
Molecular cell 2006;22(2):269-75.
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2006: Stennicke Henning R; Salvesen Guy S
Chemical ligation--an unusual paradigm in protease inhibition.
Molecular cell 2006;21(6):727-8.
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2006: Eckelman Brendan P; Salvesen Guy S
The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases.
The Journal of biological chemistry 2006;281(6):3254-60.
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2005: Pop Cristina; Salvesen Guy S
The nematode death machine in 3D.
Cell 2005;123(2):192-3.
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2005: Simonovic Miljan; Denault Jean-Bernard; Salvesen Guy S; Volz Karl; Gettins Peter G W
Lack of involvement of strand s1'A of the viral serpin CrmA in anti-apoptotic or caspase-inhibitory functions.
Archives of biochemistry and biophysics 2005;440(1):1-9.
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2005: Kato Daisuke; Boatright Kelly M; Berger Alicia B; Nazif Tamim; Blum Galia; Ryan Ciara; Chehade Kareem A H; Salvesen Guy S; Bogyo Matthew
Activity-based probes that target diverse cysteine protease families.
Nature chemical biology 2005;1(1):33-8.
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2005: Gregorc Uros; Dobersek Andreja; Salvesen Guy S; Turk Vito; Turk Boris; Kopitar-Jerala Natasa
A novel caspase-7 specific monoclonal antibody.
Immunology letters 2005;98(1):167-9.
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2005: Bruckner Shane; Rhamouni Souad; Tautz Lutz; Denault Jean-Bernard; Alonso Andres; Becattini Barbara; Salvesen Guy S; Mustelin Tomas
Yersinia phosphatase induces mitochondrially dependent apoptosis of T cells.
The Journal of biological chemistry 2005;280(11):10388-94.
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2005: Scott Fiona L; Denault Jean-Bernard; Riedl Stefan J; Shin Hwain; Renatus Martin; Salvesen Guy S
XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs.
The EMBO journal 2005;24(3):645-55.
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2005: Vucic Domagoj; Franklin Matthew C; Wallweber Heidi J A; Das Kanad; Eckelman Brendan P; Shin Hwain; Elliott Linda O; Kadkhodayan Saloumeh; Deshayes Kurt; Salvesen Guy S; Fairbrother Wayne J
Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.
The Biochemical journal 2005;385(Pt 1):11-20.
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2005: Shin Hwain; Renatus Martin; Eckelman Brendan P; Nunes Viviane A; Sampaio Claudio A M; Salvesen Guy S
The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition.
The Biochemical journal 2005;385(Pt 1):1-10.
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2004: Fuentes-Prior Pablo; Salvesen Guy S
The protein structures that shape caspase activity, specificity, activation and inhibition.
The Biochemical journal 2004;384(Pt 2):201-32.
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2004: Wilkinson John C; Wilkinson Amanda S; Scott Fiona L; Csomos Rebecca A; Salvesen Guy S; Duckett Colin S
Neutralization of Smac/Diablo by inhibitors of apoptosis (IAPs). A caspase-independent mechanism for apoptotic inhibition.
The Journal of biological chemistry 2004;279(49):51082-90.
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2004: Snipas Scott J; Wildfang Eric; Nazif Tamim; Christensen Leif; Boatright Kelly M; Bogyo Matthew; Stennicke Henning R; Salvesen Guy S
Characteristics of the caspase-like catalytic domain of human paracaspase.
Biological chemistry 2004;385(11):1093-8.
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2004: Krajewska Maryla; Rosenthal Robert E; Mikolajczyk Jowita; Stennicke Henning R; Wiesenthal Thomas; Mai Juergen; Naito Mikihiko; Salvesen Guy S; Reed John C; Fiskum Gary; Krajewski Stan
Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation.
Experimental neurology 2004;189(2):261-79.
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2004: Boatright Kelly M; Deis Cristina; Denault Jean-Bernard; Sutherlin Daniel P; Salvesen Guy S
Activation of caspases-8 and -10 by FLIP(L).
The Biochemical journal 2004;382(Pt 2):651-7.
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2004: Mikolajczyk Jowita; Scott Fiona L; Krajewski Stan; Sutherlin Daniel P; Salvesen Guy S
Activation and substrate specificity of caspase-14.
Biochemistry 2004;43(32):10560-9.
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2004: Dohi Takehiko; Okada Kazuya; Xia Fang; Wilford Casey E; Samuel Temesgen; Welsh Kate; Marusawa Hiroyouki; Zou Hua; Armstrong Robert; Matsuzawa Shu-ichi; Salvesen Guy S; Reed John C; Altieri Dario C
An IAP-IAP complex inhibits apoptosis.
The Journal of biological chemistry 2004;279(33):34087-90.
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2004: Pedersen Irene M; Zapata Juan M; Samuel Temesgen; Scott Fiona L; Salvesen Guy S; Honda Tadashi; Gribble Gordon W; Suh Nanjoo; Sporn Michael B; Kipps Thomas J; Reed John C
Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells.
Blood 2004;104(4):932.
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2004: Salvesen Guy S; Abrams John M
Caspase activation - stepping on the gas or releasing the brakes? Lessons from humans and flies.
Oncogene 2004;23(16):2774-84.
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2004: Ekici Ozlem Dogan; Götz Marion G; James Karen Ellis; Li Zhao Zhao; Rukamp Brian J; Asgian Juliana L; Caffrey Conor R; Hansell Elizabeth; Dvorák Jan; McKerrow James H; Potempa Jan; Travis James; Mikolajczyk Jowita; Salvesen Guy S; Powers James C
Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases.
Journal of medicinal chemistry 2004;47(8):1889-92.
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2004: James Karen Ellis; Asgian Juliana L; Li Zhao Zhao; Ekici Ozlem Dogan; Rubin John R; Mikolajczyk Jowita; Salvesen Guy S; Powers James C
Design, synthesis, and evaluation of aza-peptide epoxides as selective and potent inhibitors of caspases-1, -3, -6, and -8.
Journal of medicinal chemistry 2004;47(6):1553-74.
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2004: Wu Yi I; Munshi Hidayatullah G; Sen Ratna; Snipas Scott J; Salvesen Guy S; Fridman Rafael; Stack M Sharon
Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase.
The Journal of biological chemistry 2004;279(9):8278-89.
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2004: Schimmer Aaron D; Welsh Kate; Pinilla Clemencia; Wang Zhiliang; Krajewska Maryla; Bonneau Marie-Josee; Pedersen Irene M; Kitada Shinichi; Scott Fiona L; Bailly-Maitre Beatrice; Glinsky Gennadi; Scudiero Dominick; Sausville Edward; Salvesen Guy; Nefzi Adel; Ostresh John M; Houghten Richard A; Reed John C
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.
Cancer cell 2004;5(1):25-35.
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2004: Cirman Tina; Oresic Kristina; Mazovec Gabriela Droga; Turk Vito; Reed John C; Myers Richard M; Salvesen Guy S; Turk Boris
Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins.
The Journal of biological chemistry 2004;279(5):3578-87.
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2003: Boatright Kelly M; Salvesen Guy S
Mechanisms of caspase activation.
Current opinion in cell biology 2003;15(6):725-31.
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2003: Denault Jean-Bernard; Salvesen Guy S
Human caspase-7 activity and regulation by its N-terminal peptide.
The Journal of biological chemistry 2003;278(36):34042-50.
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2003: Shin Hwain; Okada Kazuya; Wilkinson John C; Solomon Katherine M; Duckett Colin S; Reed John C; Salvesen Guy S
Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein.
The Biochemical journal 2003;373(Pt 3):965-71.
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2003: Kashkar Hamid; Haefs Christiane; Shin Hwain; Hamilton-Dutoit Stephen J; Salvesen Guy S; Kronke Martin; Jurgensmeier Juliane M
XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells.
The Journal of experimental medicine 2003;198(2):341-7.
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2003: Ryan Ciara A; Salvesen Guy S
Caspases and neuronal development.
Biological chemistry 2003;384(6):855-61.
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2003: Reed John C; Doctor Kutbuddin; Rojas Ana; Zapata Juan M; Stehlik Christian; Fiorentino Loredana; Damiano Jason; Roth Wilfried; Matsuzawa Shu-Ichi; Newman Ruchi; Takayama Shinichi; Marusawa Hiroyuki; Xu Famming; Salvesen Guy; Godzik Adam;
Comparative analysis of apoptosis and inflammation genes of mice and humans.
Genome research 2003;13(6B):1376-88.
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2003: Salvesen Guy S; Scott Fiona L
Serpins are getting hotter.
Structure (London, England : 1993) 2003;11(4):364-5.
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2003: Mikolajczyk Jowita; Boatright Kelly M; Stennicke Henning R; Nazif Tamim; Potempa Jan; Bogyo Matthew; Salvesen Guy S
Sequential autolytic processing activates the zymogen of Arg-gingipain.
The Journal of biological chemistry 2003;278(12):10458-64.
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2003: Denault Jean-Bernard; Salvesen Guy S
Expression, purification, and characterization of caspases.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2003;Chapter 21():Unit 21.13.
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2003: Boatright Kelly M; Renatus Martin; Scott Fiona L; Sperandio Sabina; Shin Hwain; Pedersen Irene M; Ricci Jean Ehrland; Edris Wade A; Sutherlin Daniel P; Green Douglas R; Salvesen Guy S
A unified model for apical caspase activation.
Molecular cell 2003;11(2):529-41.
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2003: Boatright Kelly M; Salvesen Guy S
Caspase activation.
Biochemical Society symposium 2003;(70):233-42.
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2002: Denault Jean-Bernard; Salvesen Guy S
Caspases: keys in the ignition of cell death.
Chemical reviews 2002;102(12):4489-500.
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2002: Asgian Juliana L; James Karen Ellis; Li Zhao Zhao; Carter Wendy; Barrett Alan J; Mikolajczyk Jowita; Salvesen Guy S; Powers James C
Aza-peptide epoxides: a new class of inhibitors selective for clan CD cysteine proteases.
Journal of medicinal chemistry 2002;45(23):4958-60.
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2002: Ryan Ciara A; Stennicke Henning R; Nava Victor E; Burch Jennifer B; Hardwick J Marie; Salvesen Guy S
Inhibitor specificity of recombinant and endogenous caspase-9.
The Biochemical journal 2002;366(Pt 2):595-601.
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2002: Troy Carol M; Salvesen Guy S
Caspases on the brain.
Journal of neuroscience research 2002;69(2):145-50.
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2002: Gil-Parrado Shirley; Fernández-Montalván Amaury; Assfalg-Machleidt Irmgard; Popp Oliver; Bestvater Felix; Holloschi Andreas; Knoch Tobias A; Auerswald Ennes A; Welsh Katherine; Reed John C; Fritz Hans; Fuentes-Prior Pablo; Spiess Eberhard; Salvesen Guy S; Machleidt Werner
Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.
The Journal of biological chemistry 2002;277(30):27217-26.
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2002: Salvesen Guy S; Duckett Colin S
IAP proteins: blocking the road to death's door.
Nature reviews. Molecular cell biology 2002;3(6):401-10.
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2002: Okamoto Shu-ichi; Li Zhen; Ju Chung; Scholzke Marion N; Mathews Emily; Cui Jiankun; Salvesen Guy S; Bossy-Wetzel Ella; Lipton Stuart A
Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3974-9.
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2002: Salvesen Guy S; Renatus Martin
Apoptosome: the seven-spoked death machine.
Developmental cell 2002;2(3):256-7.
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2002: Denault Jean-Bernard; Salvesen Guy S
Caspases.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2002;Chapter 21():Unit 21.8.
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2002: Stennicke Henning R; Ryan Ciara A; Salvesen Guy S
Reprieval from execution: the molecular basis of caspase inhibition.
Trends in biochemical sciences 2002;27(2):94-101.
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2002: Salvesen Guy S
Caspases: opening the boxes and interpreting the arrows.
Cell death and differentiation 2002;9(1):3-5.
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2002: Salvesen Guy S
Caspases and apoptosis.
Essays in biochemistry 2002;38():9-19.
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2002: Turk Boris; Turk Dusan; Salvesen Guy S
Regulating cysteine protease activity: essential role of protease inhibitors as guardians and regulators.
Current pharmaceutical design 2002;8(18):1623-37.
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2002: Lu Chengbiao; Fu Weiming; Salvesen Guy S; Mattson Mark P
Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: implications for synaptic plasticity and excitotoxic neuronal death.
Neuromolecular medicine 2002;1(1):69-79.
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2001: Riedl S J; Fuentes-Prior P; Renatus M; Kairies N; Krapp S; Huber R; Salvesen G S; Bode W
Structural basis for the activation of human procaspase-7.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):14790-5.
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2001: Renatus M; Stennicke H R; Scott F L; Liddington R C; Salvesen G S
Dimer formation drives the activation of the cell death protease caspase 9.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(25):14250-5.
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2001: Riedl S J; Renatus M; Snipas S J; Salvesen G S
Mechanism-based inactivation of caspases by the apoptotic suppressor p35.
Biochemistry 2001;40(44):13274-80.
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2001: Snipas S J; Stennicke H R; Riedl S; Potempa J; Travis J; Barrett A J; Salvesen G S
Inhibition of distant caspase homologues by natural caspase inhibitors.
The Biochemical journal 2001;357(Pt 2):575-80.
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2001: Riedl S J; Renatus M; Schwarzenbacher R; Zhou Q; Sun C; Fesik S W; Liddington R C; Salvesen G S
Structural basis for the inhibition of caspase-3 by XIAP.
Cell 2001;104(5):791-800.
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2001: Leo E; Deveraux Q L; Buchholtz C; Welsh K; Matsuzawa S; Stennicke H R; Salvesen G S; Reed J C
TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis.
The Journal of biological chemistry 2001;276(11):8087-93.
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2001: Stoka V; Turk B; Schendel S L; Kim T H; Cirman T; Snipas S J; Ellerby L M; Bredesen D; Freeze H; Abrahamson M; Bromme D; Krajewski S; Reed J C; Yin X M; Turk V; Salvesen G S
Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route.
The Journal of biological chemistry 2001;276(5):3149-57.
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2000: Vucic D; Stennicke H R; Pisabarro M T; Salvesen G S; Dixit V M
ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas.
Current biology : CB 2000;10(21):1359-66.
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2000: Stennicke H R; Renatus M; Meldal M; Salvesen G S
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8.
The Biochemical journal 2000;350 Pt 2():563-8.
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2000: Renatus M; Zhou Q; Stennicke H R; Snipas S J; Turk D; Bankston L A; Liddington R C; Salvesen G S
Crystal structure of the apoptotic suppressor CrmA in its cleaved form.
Structure (London, England : 1993) 2000;8(7):789-97.
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2000: Lu D C; Rabizadeh S; Chandra S; Shayya R F; Ellerby L M; Ye X; Salvesen G S; Koo E H; Bredesen D E
A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor.
Nature medicine 2000;6(4):397-404.
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2000: Stennicke H R; Salvesen G S
Caspases - controlling intracellular signals by protease zymogen activation.
Biochimica et biophysica acta 2000;1477(1-2):299-306.
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2000: Huang Q; Deveraux Q L; Maeda S; Salvesen G S; Stennicke H R; Hammock B D; Reed J C
Evolutionary conservation of apoptosis mechanisms: lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1427-32.
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2000: Zhou Q; Salvesen G S
Viral caspase inhibitors CrmA and p35.
Methods in enzymology 2000;322():143-54.
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2000: Stennicke H R; Salvesen G S
Caspase assays.
Methods in enzymology 2000;322():91-100.
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1999: Deveraux Q L; Stennicke H R; Salvesen G S; Reed J C
Endogenous inhibitors of caspases.
Journal of clinical immunology 1999;19(6):388-98.
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1999: Stennicke H R; Salvesen G S
Catalytic properties of the caspases.
Cell death and differentiation 1999;6(11):1054-9.
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1999: Salvesen G S
Caspase 8: igniting the death machine.
Structure (London, England : 1993) 1999;7(10):R225-9.
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1999: Deveraux Q L; Leo E; Stennicke H R; Welsh K; Salvesen G S; Reed J C
Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases.
The EMBO journal 1999;18(19):5242-51.
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1999: Salvesen G S; Dixit V M
Caspase activation: the induced-proximity model.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):10964-7.
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1999: Wolf B B; Goldstein J C; Stennicke H R; Beere H; Amarante-Mendes G P; Salvesen G S; Green D R
Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation.
Blood 1999;94(5):1683-92.
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1999: Krajewski S; Krajewska M; Ellerby L M; Welsh K; Xie Z; Deveraux Q L; Salvesen G S; Bredesen D E; Rosenthal R E; Fiskum G; Reed J C
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5752-7.
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1999: Ellerby L M; Andrusiak R L; Wellington C L; Hackam A S; Propp S S; Wood J D; Sharp A H; Margolis R L; Ross C A; Salvesen G S; Hayden M R; Bredesen D E
Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.
The Journal of biological chemistry 1999;274(13):8730-6.
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1999: Stennicke H R; Deveraux Q L; Humke E W; Reed J C; Dixit V M; Salvesen G S
Caspase-9 can be activated without proteolytic processing.
The Journal of biological chemistry 1999;274(13):8359-62.
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1999: Salvesen G S
Programmed cell death and the caspases.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1999;107(1):73-9.
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1999: Ellerby L M; Hackam A S; Propp S S; Ellerby H M; Rabizadeh S; Cashman N R; Trifiro M A; Pinsky L; Wellington C L; Salvesen G S; Hayden M R; Bredesen D E
Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity.
Journal of neurochemistry 1999;72(1):185-95.
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1998: Yang X; Stennicke H R; Wang B; Green D R; Jänicke R U; Srinivasan A; Seth P; Salvesen G S; Froelich C J
Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.
The Journal of biological chemistry 1998;273(51):34278-83.
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1998: Cardone M H; Roy N; Stennicke H R; Salvesen G S; Franke T F; Stanbridge E; Frisch S; Reed J C
Regulation of cell death protease caspase-9 by phosphorylation.
Science (New York, N.Y.) 1998;282(5392):1318-21.
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1998: Hu S; Snipas S J; Vincenz C; Salvesen G; Dixit V M
Caspase-14 is a novel developmentally regulated protease.
The Journal of biological chemistry 1998;273(45):29648-53.
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1998: Mehlen P; Rabizadeh S; Snipas S J; Assa-Munt N; Salvesen G S; Bredesen D E
The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis.
Nature 1998;395(6704):801-4.
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1998: Stennicke H R; Jürgensmeier J M; Shin H; Deveraux Q; Wolf B B; Yang X; Zhou Q; Ellerby H M; Ellerby L M; Bredesen D; Green D R; Reed J C; Froelich C J; Salvesen G S
Pro-caspase-3 is a major physiologic target of caspase-8.
The Journal of biological chemistry 1998;273(42):27084-90.
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1998: Stennicke H R; Salvesen G S
Properties of the caspases.
Biochimica et biophysica acta 1998;1387(1-2):17-31.
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1998: Amarante-Mendes G P; Finucane D M; Martin S J; Cotter T G; Salvesen G S; Green D R
Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death.
Cell death and differentiation 1998;5(4):298-306.
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1998: Deveraux Q L; Roy N; Stennicke H R; Van Arsdale T; Zhou Q; Srinivasula S M; Alnemri E S; Salvesen G S; Reed J C
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.
The EMBO journal 1998;17(8):2215-23.
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1998: Wellington C L; Ellerby L M; Hackam A S; Margolis R L; Trifiro M A; Singaraja R; McCutcheon K; Salvesen G S; Propp S S; Bromm M; Rowland K J; Zhang T; Rasper D; Roy S; Thornberry N; Pinsky L; Kakizuka A; Ross C A; Nicholson D W; Bredesen D E; Hayden M R
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
The Journal of biological chemistry 1998;273(15):9158-67.
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1998: Takahashi R; Deveraux Q; Tamm I; Welsh K; Assa-Munt N; Salvesen G S; Reed J C
A single BIR domain of XIAP sufficient for inhibiting caspases.
The Journal of biological chemistry 1998;273(14):7787-90.
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1998: Zapata J M; Takahashi R; Salvesen G S; Reed J C
Granzyme release and caspase activation in activated human T-lymphocytes.
The Journal of biological chemistry 1998;273(12):6916-20.
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1998: Muzio M; Stockwell B R; Stennicke H R; Salvesen G S; Dixit V M
An induced proximity model for caspase-8 activation.
The Journal of biological chemistry 1998;273(5):2926-30.
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1997: Roy N; Deveraux Q L; Takahashi R; Salvesen G S; Reed J C
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases.
The EMBO journal 1997;16(23):6914-25.
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1997: Salvesen G S; Dixit V M
Caspases: intracellular signaling by proteolysis.
Cell 1997;91(4):443-6.
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1997: Stennicke H R; Salvesen G S
Biochemical characteristics of caspases-3, -6, -7, and -8.
The Journal of biological chemistry 1997;272(41):25719-23.
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1997: Caulín C; Salvesen G S; Oshima R G
Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis.
The Journal of cell biology 1997;138(6):1379-94.
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1997: Ellerby H M; Martin S J; Ellerby L M; Naiem S S; Rabizadeh S; Salvesen G S; Casiano C A; Cashman N R; Green D R; Bredesen D E
Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(16):6165-78.
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1997: Cardone M H; Salvesen G S; Widmann C; Johnson G; Frisch S M
The regulation of anoikis: MEKK-1 activation requires cleavage by caspases.
Cell 1997;90(2):315-23.
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1997: Deveraux Q L; Takahashi R; Salvesen G S; Reed J C
X-linked IAP is a direct inhibitor of cell-death proteases.
Nature 1997;388(6639):300-4.
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1997: Zhou Q; Snipas S; Orth K; Muzio M; Dixit V M; Salvesen G S
Target protease specificity of the viral serpin CrmA. Analysis of five caspases.
The Journal of biological chemistry 1997;272(12):7797-800.
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1997: Muzio M; Salvesen G S; Dixit V M
FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens.
The Journal of biological chemistry 1997;272(5):2952-6.
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1997: Salvesen G S
Serpins and programmed cell death.
Advances in experimental medicine and biology 1997;425():177-83.
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1996: Froelich C J; Hanna W L; Poirier G G; Duriez P J; D'Amours D; Salvesen G S; Alnemri E S; Earnshaw W C; Shah G M
Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment.
Biochemical and biophysical research communications 1996;227(3):658-65.
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1996: Orth K; O'Rourke K; Salvesen G S; Dixit V M
Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases.
The Journal of biological chemistry 1996;271(35):20977-80.
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1996: Quan L T; Tewari M; O'Rourke K; Dixit V; Snipas S J; Poirier G G; Ray C; Pickup D J; Salvesen G S
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(5):1972-6.
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1996: Komiyama T; Quan L T; Salvesen G S
Inhibition of cysteine and serine proteinases by the cowpox virus serpin CRMA.
Advances in experimental medicine and biology 1996;389():173-6.
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1995: Tewari M; Quan L T; O'Rourke K; Desnoyers S; Zeng Z; Beidler D R; Poirier G G; Salvesen G S; Dixit V M
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.
Cell 1995;81(5):801-9.
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1995: Quan L T; Caputo A; Bleackley R C; Pickup D J; Salvesen G S
Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.
The Journal of biological chemistry 1995;270(18):10377-9.
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1993: Strittmatter W J; Weisgraber K H; Huang D Y; Dong L M; Salvesen G S; Pericak-Vance M; Schmechel D; Saunders A M; Goldgaber D; Roses A D
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(17):8098-102.
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1993: Strittmatter W J; Saunders A M; Schmechel D; Pericak-Vance M; Enghild J; Salvesen G S; Roses A D
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(5):1977-81.
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1992: Ray C A; Black R A; Kronheim S R; Greenstreet T A; Sleath P R; Salvesen G S; Pickup D J
Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme.
Cell 1992;69(4):597-604.
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1988: Roche P A; Salvesen G S; Pizzo S V
Symmetry of the inhibitory unit of human alpha 2-macroglobulin.
Biochemistry 1988;27(20):7876-81.
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