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Varman Samuel

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Reverse Transcriptase Polymerase Chain Reaction

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Naoki Kumashiro; Romy Kursawe; Sachin K Majumdar; Vara Prasad Manchem; Kitt F Petersen; Varman T Samuel; Daniel F Vatner; Toru Yoshimura; Dongyan Zhang; Xian-Man Zhang; Sanjay Bhanot; Jennifer L Cantley; Gary W Cline; Derek M Erion; Ioana Fat; Glenn S Gerhard; Fitsum Guebre-Egziabher; Mario Kahn; Gerald I Shulman
Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats.
João Paulo G Camporez; Carla R O Carvalho; Blas A Guigni; François R Jornayvaz; Michael J Jurczak; Mario Kahn; Shoichi Kanda; Hui-Young Lee; Kitt Falk Petersen; Varman T Samuel; Gerald I Shulman
Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance.
Jennifer L Cantley; Gary W Cline; Fitsum Guebre-Egziabher; Blas A Guigni; Joseph Hankin; François R Jornayvaz; Michael J Jurczak; Mario Kahn; Naoki Kumashiro; Vara Prasad Manchem; Robert C Murphy; Varman T Samuel; Julie Serr; Sanjay Bhanot; J Mark Brown; Joao Paulo G Camporez; Toru Yoshimura; Dongyan Zhang; Gerald I Shulman
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance.

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All Publications

2013: Naoki Kumashiro; Romy Kursawe; Sachin K Majumdar; Vara Prasad Manchem; Kitt F Petersen; Varman T Samuel; Daniel F Vatner; Toru Yoshimura; Dongyan Zhang; Xian-Man Zhang; Sanjay Bhanot; Jennifer L Cantley; Gary W Cline; Derek M Erion; Ioana Fat; Glenn S Gerhard; Fitsum Guebre-Egziabher; Mario Kahn; Gerald I Shulman
Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats.
Hepatology (Baltimore, Md.) 2013;57(5):1763-72.
2013: João Paulo G Camporez; Carla R O Carvalho; Blas A Guigni; François R Jornayvaz; Michael J Jurczak; Mario Kahn; Shoichi Kanda; Hui-Young Lee; Kitt Falk Petersen; Varman T Samuel; Gerald I Shulman
Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance.
Endocrinology 2013;154(3):1021-8.
2013: Jennifer L Cantley; Gary W Cline; Fitsum Guebre-Egziabher; Blas A Guigni; Joseph Hankin; François R Jornayvaz; Michael J Jurczak; Mario Kahn; Naoki Kumashiro; Vara Prasad Manchem; Robert C Murphy; Varman T Samuel; Julie Serr; Sanjay Bhanot; J Mark Brown; Joao Paulo G Camporez; Toru Yoshimura; Dongyan Zhang; Gerald I Shulman
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(5):1869-74.
2013: Derek M Erion; Matthew P Gillum; Jennifer J Hsiao; Mario Kahn; Vara Prasad Manchem; Kisha Mitchell; Susan F Murray; Yoshio Nagai; Violetta Popov; Sanjay Bhanot; Gary W Cline; Jianying Dong; Gerald I Shulman; Daniel Vatner; Shin Yonemitsu; Varman T Samuel
The role of the carbohydrate response element-binding protein in male fructose-fed rats.
Endocrinology 2013;154(1):36-44.
2013: Eunsook S Jin; Craig R Malloy; Sara A Beddow; Varman T Samuel
Hepatic glucose production pathways after three days of a high-fat diet.
Metabolism: clinical and experimental 2013;62(1):152-62.
2012: Whitney H Brown; Joao Paulo G Camporez; Benjamin F Cravatt; Sabrina Diano; Derek M Erion; Matthew P Gillum; Blas A Guigni; Jin Kwon Jeong; Mario Kahn; Hui-Young Lee; Varman T Samuel; Tiago C Alves; Xian-Man Zhang; Gerald I Shulman
Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(37):14966-71.
2012: Sara A Beddow; Varman T Samuel
Fasting hyperglycemia in the Goto-Kakizaki rat is dependent on corticosterone: a confounding variable in rodent models of type 2 diabetes.
Disease models & mechanisms 2012;5(5):681-5.
2012: Hai-Bin Ruan; Varman T Samuel; Jay Prakash Singh; Jing Wu; Sascha Azarhoush; Anton M Bennett; Xuemei Han; Min-Dian Li; Kevin Qian; John R Yates; Lin Zhao; Xiaoyong Yang
O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability.
Cell metabolism 2012;16(2):226-37.
2012: Xiaofeng Li; Dakai Liu; Varman T Samuel; Jufang Shan; Gerald I Shulman; Ju Bao; Woochul Chang; Ingyu Kim; Ho-Jin Lee; Xinxin Zhang; Jie J Zheng; Dianqing Wu
Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(28):11402-7.
2012: Katsutaro Morino; Kitt Falk Petersen; Varman T Samuel; Cheol Soo Choi; Robert H Eckel; Amy Gallo; Ira J Goldberg; Atsunori Kashiwagi; Aiping Lin; Hiroshi Maegawa; Saki Sono; Hong Wang; Hongyu Zhao; Gerald I Shulman
Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes.
Diabetes 2012;61(4):877-87.
2012: Varman T Samuel; Gerald I Shulman
Mechanisms for insulin resistance: common threads and missing links.
Cell 2012;148(5):852-71.
2012: Wenzhong Liu; Varman T Samuel; Gerald I Shulman; Rajvir Singh; Cheol Soo Choi; Ali R Keramati; Hui-Young Lee; Richard P Lifton; Arya Mani
Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure.
The Journal of biological chemistry 2012;287(10):7213-23.
2012: François R Jornayvaz; Michael J Jurczak; Hui-Young Lee; Varman T Samuel; Tiago C Alves; Fitsum Guebre-Egziabher; Blas A Guigni; J Enrique Silva; Dongyan Zhang; Gerald I Shulman
Thyroid hormone receptor-α gene knockout mice are protected from diet-induced hepatic insulin resistance.
Endocrinology 2012;153(2):583-91.
2012: Michael J Jurczak; Mario Kahn; Ann-Hwee Lee; Hui-Young Lee; Varman T Samuel; Andreas L Birkenfeld; Laurie H Glimcher; Blas A Guigni; François R Jornayvaz; Gerald I Shulman
Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice.
The Journal of biological chemistry 2012;287(4):2558-67.
2011: Alexander S Banks; Rebecca A Haeusler; Garrett Heinrich; Michael J Jurczak; Ja Young Kim-Muller; Natalie M Kofler; Dina Laznik; Teresa L Mastracci; Virginia E Papaioannou; Li Qiang; Varman T Samuel; Gerald I Shulman; Domenico Accili
Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice.
Cell metabolism 2011;14(5):587-97.
2011: Hui-Young Lee; Jae-Hak Park; Kitt F Petersen; Violeta Popov; Varman T Samuel; Dongyan Zhang; Kalyani G Bharadwaj; Andreas L Birkenfeld; Cheol Soo Choi; David W Frederick; Ira J Goldberg; Blas Guigni; François R Jornayvaz; Michael J Jurczak; Shoichi Kanda; Gerald I Shulman
Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance.
Hepatology (Baltimore, Md.) 2011;54(5):1650-60.
2011: Andreas L Birkenfeld; Joao Paulo Camporez; David W Frederick; Blas Guigni; François R Jornayvaz; Michael J Jurczak; Mario Kahn; Hui-Young Lee; Stefanie Lieske; Sachin Majumdar; Seiichi Oyadomari; Andreas F Pfeiffer; David Ron; Varman T Samuel; Dirk Weismann; Dongyang Zhang; Ayman M Arafat; Gerald I Shulman
Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism.
The Journal of biological chemistry 2011;286(42):36163-70.
2011: Naoki Kumashiro; Kitt Falk Petersen; Varman T Samuel; Sara A Beddow; Xin Chu; James Dziura; Derek M Erion; Glenn S Gerhard; Xianlin Han; Mario Kahn; Christopher D Still; Dongyan Zhang; Gerald I Shulman
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(39):16381-5.
2011: Utpal B Pajvani; Varman T Samuel; Carrie J Shawber; Gerald I Shulman; Andreas L Birkenfeld; Jan Kitajewski; Domenico Accili
Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner.
Nature medicine 2011;17(8):961-7.
2011: Maryam Ahmadian; Marcia J Abbott; Tianyi Tang; Carolyn S S Hudak; Yangha Kim; Matthew Bruss; Marc K Hellerstein; Hui-Young Lee; Varman T Samuel; Gerald I Shulman; Yuhui Wang; Robin E Duncan; Chulho Kang; Hei Sook Sul
Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype.
Cell metabolism 2011;13(6):739-48.
2011: François R Jornayvaz; Andreas L Birkenfeld; Michael J Jurczak; Shoichi Kanda; Blas A Guigni; Debbie C Jiang; Dongyan Zhang; Hui-Young Lee; Varman T Samuel; Gerald I Shulman
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(14):5748-52.
2011: James W Perfield; Yunkyoung Lee; Gerald I Shulman; Varman T Samuel; Michael J Jurczak; Eugene Chang; Chen Xie; Phillip N Tsichlis; Martin S Obin; Andrew S Greenberg
Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance.
Diabetes 2011;60(4):1168-76.
2011: D Weismann; D M Erion; I Ignatova-Todorava; Y Nagai; R Stark; J J Hsiao; C Flannery; A L Birkenfeld; T May; M Kahn; D Zhang; Xing Xian Yu; S F Murray; Sanjay Bhanot; Brett P Monia; Gary W Cline; Gerald I Shulman; Varman T Samuel
Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance.
Diabetologia 2011;54(4):935-44.
2011: Serkan Kir; Sara A Beddow; Varman T Samuel; Paul Miller; Stephen F Previs; Kelly Suino-Powell; H Eric Xu; Gerald I Shulman; Steven A Kliewer; David J Mangelsdorf
FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis.
Science (New York, N.Y.) 2011;331(6024):1621-4.
2011: Michael J Jurczak; Hui-Young Lee; Andreas L Birkenfeld; Francois R Jornayvaz; David W Frederick; Rebecca L Pongratz; Xiaoxian Zhao; Gilbert W Moeckel; Varman T Samuel; Jean M Whaley; Gerald I Shulman; Richard G Kibbey
SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function.
Diabetes 2011;60(3):890-8.
2011: Hua V Lin; Hongxia Ren; Varman T Samuel; Hui-Young Lee; Taylor Y Lu; Gerald I Shulman; Domenico Accili
Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues.
Diabetes 2011;60(3):700-9.
2011: Varman T Samuel
Fructose induced lipogenesis: from sugar to fat to insulin resistance.
Trends in endocrinology and metabolism: TEM 2011;22(2):60-5.
2010: Hui-Young Lee; Cheol Soo Choi; Andreas L Birkenfeld; Tiago C Alves; François R Jornayvaz; Michael J Jurczak; Dongyan Zhang; Dong Kyun Woo; Gerald S Shadel; Warren Ladiges; Peter S Rabinovitch; Janine H Santos; Kitt F Petersen; Varman T Samuel; Gerald I Shulman
Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.
Cell metabolism 2010;12(6):668-74.
2010: François R Jornayvaz; Michael J Jurczak; Hui-Young Lee; Andreas L Birkenfeld; David W Frederick; Dongyang Zhang; Xian-Man Zhang; Varman T Samuel; Gerald I Shulman
A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain.
American journal of physiology. Endocrinology and metabolism 2010;299(5):E808-15.
2010: Julio E Ayala; Varman T Samuel; Gregory J Morton; Silvana Obici; Colleen Croniger; Gerald I Shulman; David H Wasserman; Owen P McGuinness
Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice.
Disease models & mechanisms 2010;3(9-10):525-34.
2010: François R Jornayvaz; Varman T Samuel; Gerald I Shulman
The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome.
Annual review of nutrition 2010;30():273-90.
2010: Varman T Samuel; Kitt Falk Petersen; Gerald I Shulman
Lipid-induced insulin resistance: unravelling the mechanism.
Lancet 2010;375(9733):2267-77.
2010: William A Chutkow; Andreas L Birkenfeld; Jonathan D Brown; Hui-Young Lee; David W Frederick; Jun Yoshioka; Parth Patwari; Romy Kursawe; Samuel W Cushman; Jorge Plutzky; Gerald I Shulman; Varman T Samuel; Richard T Lee
Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity.
Diabetes 2010;59(6):1424-34.
2009: Derek M Erion; Irena D Ignatova; Shin Yonemitsu; Yoshio Nagai; Paula Chatterjee; Dirk Weismann; Jennifer J Hsiao; Dongyan Zhang; Takanori Iwasaki; Romana Stark; Clare Flannery; Mario Kahn; Christopher M Carmean; Xing Xian Yu; Susan F Murray; Sanjay Bhanot; Brett P Monia; Gary W Cline; Varman T Samuel; Gerald I Shulman
Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein.
Cell metabolism 2009;10(6):499-506.
2009: Rachel J Roth; Annie M Le; Lei Zhang; Mario Kahn; Varman T Samuel; Gerald I Shulman; Anton M Bennett
MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice.
The Journal of clinical investigation 2009;119(12):3817-29.
2009: Varman T Samuel; Sara A Beddow; Takanori Iwasaki; Xian-Man Zhang; Xin Chu; Christopher D Still; Glenn S Gerhard; Gerald I Shulman
Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):12121-6.
2009: Derek M Erion; Shin Yonemitsu; Yongzhan Nie; Yoshio Nagai; Matthew P Gillum; Jennifer J Hsiao; Takanori Iwasaki; Romana Stark; Dirk Weismann; Xing Xian Yu; Susan F Murray; Sanjay Bhanot; Brett P Monia; Tamas L Horvath; Qian Gao; Varman T Samuel; Gerald I Shulman
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(27):11288-93.
2009: Maryam Ahmadian; Robin Duncan; Kristina A. Varady; Danubia Frasson; Marc K Hellerstein; Andreas L Birkenfeld; Varman T Samuel; Gerald I Shulman; Yuhui Wang; Chulho Kang; Hei Sook Sul
Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity.
Diabetes 2009;58(4):855-66.
2009: Yoshio Nagai; Shin Yonemitsu; Derek M Erion; Takanori Iwasaki; Romana Stark; Dirk Weismann; Jianying Dong; Dongyan Zhang; Michael J Jurczak; Michael Löffler; James Cresswell; Xing Xian Yu; Susan F Murray; Sanjay Bhanot; Brett P Monia; Jonathan S Bogan; Varman T Samuel; Gerald I Shulman
The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.
Cell metabolism 2009;9(3):252-64.
2009: Kathy Jaworski; Maryam Ahmadian; Robin Duncan; Eszter Sarkadi-Nagy; Kristina A. Varady; Marc K Hellerstein; Hui-Young Lee; Varman T Samuel; Gerald I Shulman; Kee-Hong Kim; Sarah De Val; Chulho Kang; Hei Sook Sul
AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency.
Nature medicine 2009;15(2):159-68.
2008: Katsutaro Morino; Susanne Neschen; Stefan Bilz; Saki Sono; Dimitrios Tsirigotis; Richard M Reznick; Irene Moore; Yoshio Nagai; Varman T Samuel; David Sebastian; Morris White; William Philbrick; Gerald I Shulman
Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle.
Diabetes 2008;57(10):2644-51.
2007: Esben S Buhl; Susanne Neschen; Shin Yonemitsu; Jörg Rossbacher; Dongyan Zhang; Katsutaro Morino; Allan Flyvbjerg; Pascale Perret; Varman T Samuel; Jung Kim; Gary W Cline; Kitt Falk Petersen
Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats.
American journal of physiology. Endocrinology and metabolism 2007;293(5):E1451-8.
2007: Cheol Soo Choi; David B Savage; Ameya Kulkarni; Xing Xian Yu; Zhen-Xiang Liu; Katsutaro Morino; Sheene Kim; Alberto Distefano; Varman T Samuel; Susanne Neschen; Dongyan Zhang; Amy Wang; Xian-Man Zhang; Mario Kahn; Gary W Cline; Sanjay K Pandey; John Gerard Geisler; Sanjay Bhanot; Brett P Monia; Gerald I Shulman
Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.
The Journal of biological chemistry 2007;282(31):22678-88.
2007: Varman T Samuel; Zhen-Xiang Liu; Amy Wang; Sara A Beddow; John Gerard Geisler; Mario Kahn; Xian-Man Zhang; Brett P Monia; Sanjay Bhanot; Gerald I Shulman
Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease.
The Journal of clinical investigation 2007;117(3):739-45.
2006: Varman T Samuel; Cheol Soo Choi; Trevor G Phillips; Anthony J Romanelli; John Gerard Geisler; Sanjay Bhanot; Robert McKay; Brett P Monia; John R Shutter; Richard A Lindberg; Gerald I Shulman; Murielle M Veniant
Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action.
Diabetes 2006;55(7):2042-50.
2006: Stefan Bilz; Varman T Samuel; Katsutaro Morino; David Savage; Cheol Soo Choi; Gerald I Shulman
Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters.
American journal of physiology. Endocrinology and metabolism 2006;290(4):E716-22.
2006: David B Savage; Cheol Soo Choi; Varman T Samuel; Zhen-Xiang Liu; Dongyan Zhang; Amy Wang; Xian-Man Zhang; Gary W Cline; Xing Xian Yu; John Gerard Geisler; Sanjay Bhanot; Brett P Monia; Gerald I Shulman
Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.
The Journal of clinical investigation 2006;116(3):817-24.
2004: Varman T Samuel; Zhen-Xiang Liu; Xianqin Qu; Benjamin D Elder; Stefan Bilz; Douglas Befroy; Anthony J Romanelli; Gerald I Shulman
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.
The Journal of biological chemistry 2004;279(31):32345-53.