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Jude Samulski

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Marc S Weinberg; R Jude Samulski; Thomas J McCown
Adeno-associated virus (AAV) gene therapy for neurological disease.
Yi He; Matt Hirsch; Mark C Johnson; R Jude Samulski; Roland Tisch; Marc S Weinberg; Chengwen Li
Kinetics of Adeno-Associated Virus Serotype 2 (AAV2) and AAV8 Capsid Antigen Presentation In Vivo Are Identical.
Balasubramanian Venkatakrishnan; Joseph Yarbrough; Antonette Bennett; Brian Bothner; John Domsic; Olga G Kozyreva; Robert McKenna; Nicholas Muzyczka; R Jude Samulski; Mavis Agbandje-McKenna
Structure and dynamics of adeno-associated virus serotype 1 VP1-unique N-terminal domain and its role in capsid trafficking.

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All Publications

2013: Marc S Weinberg; R Jude Samulski; Thomas J McCown
Adeno-associated virus (AAV) gene therapy for neurological disease.
Neuropharmacology 2013;69():82-8.
2013: Yi He; Matt Hirsch; Mark C Johnson; R Jude Samulski; Roland Tisch; Marc S Weinberg; Chengwen Li
Kinetics of Adeno-Associated Virus Serotype 2 (AAV2) and AAV8 Capsid Antigen Presentation In Vivo Are Identical.
Human gene therapy 2013;24(5):545-53.
2013: Balasubramanian Venkatakrishnan; Joseph Yarbrough; Antonette Bennett; Brian Bothner; John Domsic; Olga G Kozyreva; Robert McKenna; Nicholas Muzyczka; R Jude Samulski; Mavis Agbandje-McKenna
Structure and dynamics of adeno-associated virus serotype 1 VP1-unique N-terminal domain and its role in capsid trafficking.
Journal of virology 2013;87(9):4974-84.
2013: Marina O'Reilly; Eugene Rosenthal; R Jude Samulski; Sonia I Skarlatos; Brian Sorrentino; James M Wilson; Yun Xie; Jeffrey Bartlett; Janet Benson; Philip J Brooks; Barry J Byrne; Carlos Camozzi; Kenneth Cornetta; Ronald G Crystal; Yuman Fong; Linda Gargiulo; Rashmi Gopal-Srivastava; Katherine A High; Samuel G Jacobson; Robert C Jambou; Donald B Kohn; Maureen Montgomery; Jacqueline Corrigan-Curay
Gene therapy for rare diseases: summary of a national institutes of health workshop, september 13, 2012.
Human gene therapy 2013;24(4):355-62.
2013: Angela M Mitchell; Chengwen Li; R Jude Samulski
Arsenic trioxide stabilizes accumulations of adeno-associated virus virions at the perinuclear region, increasing transduction in vitro and in vivo.
Journal of virology 2013;87(8):4571-83.
2013: Chengwen Li; Sarah Nicolson; Yi He; Matt Hirsch; Tal Kafri; Marc S Weinberg; Ping Zhang; R Jude Samulski
Adeno-associated virus capsid antigen presentation is dependent on endosomal escape.
The Journal of clinical investigation 2013;123(3):1390-401.
2013: Kenneth M Fish; Lahouaria Hadri; Kiyotake Ishikawa; Dongtak Jeong; Ioannis Karakikes; Yoshiaki Kawase; Evangelia G Kranias; Dennis Ladage; Hung Ly; Jochen Muller-Ehmsen; R Jude Samulski; Lisa Tilemann; Roger J Hajjar
AAV9.I-1c delivered via direct coronary infusion in a porcine model of heart failure improves contractility and mitigates adverse remodeling.
Circulation. Heart failure 2013;6(2):310-7.
2013: Silke Mussche; Sahana Nagabhushan Kalburgi; R Jude Samulski; Hung-Jui Shih; Rudy Van Coster; Lavanya Bachaboina; Bart Devreese; Jonathan C Fox; Steven J Gray
Restoration of cytoskeleton homeostasis after gigaxonin gene transfer for giant axonal neuropathy.
Human gene therapy 2013;24(2):209-19.
2013: Incilay Sinici; Ilona Tkachyova; Warren Wakarchuk; Sayuri Yonekawa; Steven J Gray; Brian L Mark; R Jude Samulski; Don J Mahuran
In cellulo examination of a beta-alpha hybrid construct of beta-hexosaminidase A subunits, reported to interact with the GM2 activator protein and hydrolyze GM2 ganglioside.
PloS one 2013;8(3):e57908.
2013: Laurie R Goodrich; Steven J Gray; Joshua C Grieger; C Wayne McIlwraith; Jennifer N Phillips; Stacey B Foti; R Jude Samulski
Optimization of scAAVIL-1ra In Vitro and In Vivo to Deliver High Levels of Therapeutic Protein for Treatment of Osteoarthritis.
Molecular therapy. Nucleic acids 2013;2():e70.
2013: Kamal K E Gadalla; Steven J Gray; Sahana Nagabhushan Kalburgi; Paul D Ross; R Jude Samulski; Rosemary C Spike; Anne E West; Kenton T Woodard; Lavanya Bachaboina; Mark E S Bailey; Jie V Deng; Stuart R Cobb
Improved survival and reduced phenotypic severity following AAV9/MECP2 gene transfer to neonatal and juvenile male Mecp2 knockout mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(1):18-30.
2012: Paola Leone; S W J McPhee; R Jude Samulski; David Shera; Dah-Jyuu Wang; Deborah Young; Edwin H Kolodny; Mitra Assadi; Larissa T Bilaniuk; Matthew J During; Jeremy S Francis; Andrew Freese; Olga Goldfarb; H Warren Goldman; Christopher G Janson
Long-term follow-up after gene therapy for canavan disease.
Science translational medicine 2012;4(165):165ra163.
2012: Thomas B Lentz; Steven J Gray; R Jude Samulski
Viral vectors for gene delivery to the central nervous system.
Neurobiology of disease 2012;48(2):179-88.
2012: Ping-Jie Xiao; R Jude Samulski
Cytoplasmic trafficking, endosomal escape, and perinuclear accumulation of adeno-associated virus type 2 particles are facilitated by microtubule network.
Journal of virology 2012;86(19):10462-73.
2012: Chengwen Li; Paul E Monahan; Joseph Rabinowitz; Mavis Agbandje-McKenna; Aravind Asokan; Dawn E Bowles; Nina Diprimio; Matthew L Hirsch; R Jude Samulski
Single amino acid modification of adeno-associated virus capsid changes transduction and humoral immune profiles.
Journal of virology 2012;86(15):7752-9.
2012: Thais Federici; S J Gray; J C Grieger; C R Handy; K A Matthews; M A Passini; R Jude Samulski; J S Taub; G R Baum; Nicholas M Boulis
Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs.
Gene therapy 2012;19(8):852-9.
2012: Ping-Jie Xiao; Thomas B Lentz; R Jude Samulski
Recombinant adeno-associated virus: clinical application and development as a gene-therapy vector.
Therapeutic delivery 2012;3(7):835-56.
2012: Olivier Bockstael; Olivier De Witte; Marc Levivier; Douglas McCarty; C Melas; Catherine Pythoud; R Jude Samulski; Liliane Tenenbaum
Rapid transgene expression in multiple precursor cell types of adult rat subventricular zone mediated by adeno-associated type 1 vectors.
Human gene therapy 2012;23(7):742-53.
2012: Jerome Denard; Luis Garcia; Robert Kotin; René Lai-Kuen; Hervé Leh; Philippe Moullier; R Jude Samulski; Aravind Asokan; Cyriaque Beley; Stéphane Blot; Thomas Voit; Fedor Svinartchouk
Human galectin 3 binding protein interacts with recombinant adeno-associated virus type 6.
Journal of virology 2012;86(12):6620-31.
2012: Valentino Piacentino; Michael Bolanos; Nenad Bursac; Adam S Cockrell; Gayathri Devi; Edward Jones; Ava Krol; Lan Mao; Emily Messina; Carmelo A Milano; R Jude Samulski; Jacob Schroder; Dawn E Bowles
X-linked inhibitor of apoptosis protein-mediated attenuation of apoptosis, using a novel cardiac-enhanced adeno-associated viral vector.
Human gene therapy 2012;23(6):635-46.
2012: Chengwen Li; M J Manco-Johnson; P E Monahan; N Narkbunnam; R Jude Samulski; Aravind Asokan; G Hu; Linda J Jacobson
Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia.
Gene therapy 2012;19(3):288-94.
2012: Ping-Jie Xiao; Chengwen Li; Aaron Neumann; R Jude Samulski
Quantitative 3D tracing of gene-delivery viral vectors in human cells and animal tissues.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(2):317-28.
2012: Dawn E Bowles; Angelique S Camp; Lakshmanan Govindasamy; Steven J Gray; Joshua C Grieger; Chengwen Li; Juan Li; Scott W J McPhee; Paul E Monahan; Joseph E Rabinowitz; Jade J Samulski; Bing Wang; Xiao Xiao; Mavis Agbandje-McKenna; R Jude Samulski
Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(2):443-55.
2012: Joshua C Grieger; R Jude Samulski
Adeno-associated virus vectorology, manufacturing, and clinical applications.
Methods in enzymology 2012;507():229-54.
2011: Steven J Gray; Rebecca A Haberman; Thomas J McCown; Aravind Asokan; Vivian W Choi; R Jude Samulski
Production of recombinant adeno-associated viral vectors and use in in vitro and in vivo administration.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2011;Chapter 4():Unit 4.17.
2011: M S Weinberg; R Jude Samulski; B L Blake; Thomas J McCown
The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5.
Gene therapy 2011;18(10):961-8.
2011: Wuping Li; Raymond J Pickles; Zhijian Wu; Liqun Zhang; R Jude Samulski
AAV-6 mediated efficient transduction of mouse lower airways.
Virology 2011;417(2):327-33.
2011: Steven J Gray; Thomas J McCown; Joel W Schwartz; Bonnie Taylor-Blake; Mark J Zylka; Lavanya Bachaboina; Jennifer Coleman; Michael D Ehlers; Stacey B Foti; R Jude Samulski
Optimizing promoters for recombinant adeno-associated virus-mediated gene expression in the peripheral and central nervous system using self-complementary vectors.
Human gene therapy 2011;22(9):1143-53.
2011: Brooke R Snyder; Nicholas M Boulis; Steven J Gray; Jeremiah W Huang; Cary H Leung; Eric T Quach; R Jude Samulski; Thais Federici
Comparison of adeno-associated viral vector serotypes for spinal cord and motor neuron gene delivery.
Human gene therapy 2011;22(9):1129-35.
2011: Chengwen Li; Marc Scott Weinberg; Pingjie Xiao; Steven James Gray; R Jude Samulski
Combination therapy utilizing shRNA knockdown and an optimized resistant transgene for rescue of diseases caused by misfolded proteins.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(34):14258-63.
2011: Steven J Gray; Valerie Matagne; Lavanya Bachaboina; Swati Yadav; Sergio R Ojeda; R Jude Samulski
Preclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primates.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(6):1058-69.
2011: Jarrod S Johnson; Martina Gentzsch; Liqun Zhang; Carla M P Ribeiro; Boris Kantor; Tal Kafri; Raymond J Pickles; R Jude Samulski
AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis.
PLoS pathogens 2011;7(5):e1002053.
2011: Kevin S Goudy; Mark C Johnson; Alaina Garland; Chengwen Li; R Jude Samulski; Bo Wang; Roland Tisch
Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity.
European journal of immunology 2011;41(5):1480-90.
2011: Kevin S Goudy; Mark C Johnson; Alaina Garland; Chengwen Li; R Jude Samulski; Bo Wang; Roland Tisch
Inducible adeno-associated virus-mediated IL-2 gene therapy prevents autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(6):3779-86.
2011: Matthew L Hirsch; Larysa Pevny; Matthew H Porteus; Jacquelyn J Bower; Raluca Dumitru; B Matthew Fagan; Swati Yadav; R Jude Samulski
Viral single-strand DNA induces p53-dependent apoptosis in human embryonic stem cells.
PloS one 2011;6(11):e27520.
2011: Jana L Phillips; Julia Hegge; Jon A Wolff; R Jude Samulski; Aravind Asokan
Systemic gene transfer to skeletal muscle using reengineered AAV vectors.
Methods in molecular biology (Clifton, N.J.) 2011;709():141-51.
2010: Robert Ng; Lakshmanan Govindasamy; Brittney L Gurda; Robert McKenna; Olga G Kozyreva; R Jude Samulski; Kristin N Parent; Timothy S Baker; Mavis Agbandje-McKenna
Structural characterization of the dual glycan binding adeno-associated virus serotype 6.
Journal of virology 2010;84(24):12945-57.
2010: Paul E Monahan; Clinton D Lothrop; Junjiang Sun; Matthew L Hirsch; Tal Kafri; Boris Kantor; Rita Sarkar; D Michael Tillson; Joseph R Elia; R Jude Samulski
Proteasome inhibitors enhance gene delivery by AAV virus vectors expressing large genomes in hemophilia mouse and dog models: a strategy for broad clinical application.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(11):1907-16.
2010: Jerry R Mendell; Katherine Campbell; Louise Rodino-Klapac; Zarife Sahenk; Chris Shilling; Sarah Lewis; Dawn Bowles; Steven Gray; Chengwen Li; Gloria Galloway; Vinod Malik; Brian Coley; K Reed Clark; Juan Li; Xiao Xiao; Jade Samulski; Scott W McPhee; R Jude Samulski; Christopher M Walker
Dystrophin immunity in Duchenne's muscular dystrophy.
The New England journal of medicine 2010;363(15):1429-37.
2010: Steven J Gray; Kenton T Woodard; R Jude Samulski
Viral vectors and delivery strategies for CNS gene therapy.
Therapeutic delivery 2010;1(4):517-34.
2010: Nina DiPrimio; Scott W J McPhee; R Jude Samulski
Adeno-associated virus for the treatment of muscle diseases: toward clinical trials.
Current opinion in molecular therapeutics 2010;12(5):553-60.
2010: Angela M Mitchell; Sarah C Nicolson; Jayme K Warischalk; R Jude Samulski
AAV's anatomy: roadmap for optimizing vectors for translational success.
Current gene therapy 2010;10(5):319-40.
2010: Jarrod S Johnson; Chengwen Li; Nina DiPrimio; Marc S Weinberg; Thomas J McCown; R Jude Samulski
Mutagenesis of adeno-associated virus type 2 capsid protein VP1 uncovers new roles for basic amino acids in trafficking and cell-specific transduction.
Journal of virology 2010;84(17):8888-902.
2010: M L Hirsch; L Green; M H Porteus; R Jude Samulski
Self-complementary AAV mediates gene targeting and enhances endonuclease delivery for double-strand break repair.
Gene therapy 2010;17(9):1175-80.
2010: Edmund R Hollis; Pouya Jamshidi; Ariana O Lorenzana; Jae Lee; Steven J Gray; R Jude Samulski; Binhai Zheng; Mark H Tuszynski
Transient demyelination increases the efficiency of retrograde AAV transduction.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(8):1496-500.
2010: Shufen Chen; Christie A Sanford; Junjiang Sun; Vivian Choi; Terry Van Dyke; R Jude Samulski; Wendy Rathmell
VHL and PTEN loss coordinate to promote mouse liver vascular lesions.
Angiogenesis 2010;13(1):59-69.
2010: Steven J Gray; Bonita L Blake; Hugh E Criswell; Sarah C Nicolson; R Jude Samulski; Thomas J McCown; Wuping Li
Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB).
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(3):570-8.
2010: Eleni A Markakis; Kenneth P Vives; Jeremy Bober; Stefan Leichtle; Csaba Leranth; Jeff Beecham; John D Elsworth; Robert H Roth; R Jude Samulski; D Eugene Redmond
Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brain.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(3):588-93.
2010: F Curtis Hewitt; R Jude Samulski
Creating a novel origin of replication through modulating DNA-protein interfaces.
PloS one 2010;5(1):e8850.
2010: Matthew L Hirsch; Mavis Agbandje-McKenna; R Jude Samulski
Little vector, big gene transduction: fragmented genome reassembly of adeno-associated virus.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(1):6-8.
2010: Aravind Asokan; Julia C Conway; Jana L Phillips; Chengwen Li; Julia Hegge; Rebecca Sinnott; Swati Yadav; Nina DiPrimio; Hyun-Joo Nam; Mavis Agbandje-McKenna; Scott McPhee; Jon Wolff; R Jude Samulski
Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle.
Nature biotechnology 2010;28(1):79-82.
2010: LaKisha K Buie; Carol A Rasmussen; Eric C Porterfield; Vinod S Ramgolam; Vivian W Choi; Silva Markovic-Plese; R Jude Samulski; Paul L Kaufman; Teresa Borrás
Self-complementary AAV virus (scAAV) safe and long-term gene transfer in the trabecular meshwork of living rats and monkeys.
Investigative ophthalmology & visual science 2010;51(1):236-48.
2009: Laurie R Goodrich; V W Choi; B A Duda Carbone; Wayne McIlwraith; R Jude Samulski
Ex vivo serotype-specific transduction of equine joint tissue by self-complementary adeno-associated viral vectors.
Human gene therapy 2009;20(12):1697-702.
2009: Wuping Li; Liqun Zhang; Jarrod S Johnson; Wu Zhijian; Joshua C Grieger; Xiao Ping-Jie; Lauren M Drouin; Mavis Agbandje-McKenna; Raymond J Pickles; R Jude Samulski
Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(12):2067-77.
2009: S B Foti; R Jude Samulski; Thomas J McCown
Delivering multiple gene products in the brain from a single adeno-associated virus vector.
Gene therapy 2009;16(11):1314-9.
2009: Karen M Frank; D Kyle Hogarth; Jonathan L Miller; Saptarshi Mandal; Philip J Mease; R Jude Samulski; Glen A Weisgerber; John Hart
Investigation of the cause of death in a gene-therapy trial.
The New England journal of medicine 2009;361(2):161-9.
2009: D Eugene Redmond; John D Elsworth; Robert H Roth; Csaba Leranth; Timothy J Collier; Barbara C Blanchard; Kimberly B Bjugstad; R Jude Samulski; P Aebischer; John R Sladek
Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF.
The Journal of comparative neurology 2009;515(1):31-40.
2009: Chengwen Li; Matt Hirsch; Nina DiPrimio; Aravind Asokan; Kevin Goudy; Roland Tisch; R Jude Samulski
Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo.
Journal of virology 2009;83(13):6817-24.
2009: Chengwen Li; Kevin Goudy; Matt Hirsch; Aravind Asokan; Yun Fan; Jeff Alexander; Junjiang Sun; Paul E Monahan; David Seiber; John Sidney; Alessandro Sette; Roland Tisch; Jeffrey Frelinger; R Jude Samulski
Cellular immune response to cryptic epitopes during therapeutic gene transfer.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(26):10770-4.
2009: S W J McPhee; R Jude Samulski
Gene therapy for cardiomyocytes, a heart beat away.
Gene therapy 2009;16(6):707-8.
2009: F Curtis Hewitt; Chengwen Li; Steven J Gray; Shelley Cockrell; Michael Washburn; R Jude Samulski
Reducing the risk of adeno-associated virus (AAV) vector mobilization with AAV type 5 vectors.
Journal of virology 2009;83(8):3919-29.
2009: Jarrod S Johnson; R Jude Samulski
Enhancement of adeno-associated virus infection by mobilizing capsids into and out of the nucleolus.
Journal of virology 2009;83(6):2632-44.
2009: Matthew L Hirsch; Francesca Storici; Chengwen Li; Vivian W Choi; R Jude Samulski
AAV recombineering with single strand oligonucleotides.
PloS one 2009;4(11):e7705.
2009: Chengwen Li; M Hirsch; P Carter; Aravind Asokan; X Zhou; Zhijian Wu; R Jude Samulski
A small regulatory element from chromosome 19 enhances liver-specific gene expression.
Gene therapy 2009;16(1):43-51.
2008: Junjiang Sun; Narine Hakobyan; Leonard A Valentino; Brian L Feldman; R Jude Samulski; Paul E Monahan
Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX.
Blood 2008;112(12):4532-41.
2008: Aravind Asokan; J S Johnson; C Li; R Jude Samulski
Bioluminescent virion shells: new tools for quantitation of AAV vector dynamics in cells and live animals.
Gene therapy 2008;15(24):1618-22.
2008: Cemal Yazici; Laura Yanoso; Chao Xie; David G Reynolds; R Jude Samulski; Jade Samulski; Judith Yannariello-Brown; Arthur A Gertzman; Xinping Zhang; Hani Awad; Edward M Schwarz
The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings.
Biomaterials 2008;29(28):3882-7.
2008: Steven J Gray; R Jude Samulski
Optimizing gene delivery vectors for the treatment of heart disease.
Expert opinion on biological therapy 2008;8(7):911-22.
2008: Wuping Li; Aravind Asokan; Zhijian Wu; Terry Van Dyke; Nina DiPrimio; Jarrod S Johnson; Lakshmanan Govindaswamy; Mavis Agbandje-McKenna; Stefan Leichtle; D Eugene Redmond; Thomas J McCown; Kimberly B Petermann; Norman E Sharpless; R Jude Samulski
Engineering and selection of shuffled AAV genomes: a new strategy for producing targeted biological nanoparticles.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(7):1252-60.
2008: Nina DiPrimio; Aravind Asokan; Lakshmanan Govindasamy; Mavis Agbandje-McKenna; R Jude Samulski
Surface loop dynamics in adeno-associated virus capsid assembly.
Journal of virology 2008;82(11):5178-89.
2008: John D Elsworth; D Eugene Redmond; Csaba Leranth; Kimberly B Bjugstad; John R Sladek; Timothy J Collier; S B Foti; R Jude Samulski; Kenneth P Vives; Robert H Roth
AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons.
Experimental neurology 2008;211(1):252-8.
2008: Xiaohuai Zhou; Xinghua Zeng; Zhenghong Fan; Chengwen Li; Thomas J McCown; R Jude Samulski; Xiao Xiao
Adeno-associated virus of a single-polarity DNA genome is capable of transduction in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(3):494-9.
2008: Edmund R Hollis; Ken Kadoya; Matthew Hirsch; R Jude Samulski; Mark H Tuszynski
Efficient retrograde neuronal transduction utilizing self-complementary AAV1.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(2):296-301.
2008: Li Zhong; Xiaohuai Zhou; Yanjun Li; Keyun Qing; Xiao Xiao; R Jude Samulski; Arun Srivastava
Single-polarity recombinant adeno-associated virus 2 vector-mediated transgene expression in vitro and in vivo: mechanism of transduction.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(2):290-5.
2008: Zhijian Wu; Junjiang Sun; Taiping Zhang; Chaoying Yin; Fang Yin; Terry Van Dyke; R Jude Samulski; Paul E Monahan
Optimization of self-complementary AAV vectors for liver-directed expression results in sustained correction of hemophilia B at low vector dose.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(2):280-9.
2008: A R Lyon; M Sato; R J Hajjar; R Jude Samulski; S E Harding
Gene therapy: targeting the myocardium.
Heart (British Cardiac Society) 2008;94(1):89-99.
2007: S Foti; Rebecca P Haberman; R Jude Samulski; Thomas J McCown
Adeno-associated virus-mediated expression and constitutive secretion of NPY or NPY13-36 suppresses seizure activity in vivo.
Gene therapy 2007;14(21):1534-6.
2007: Jinhui Wang; Jing Xie; Hui Lu; Lingxia Chen; Bernd Hauck; R Jude Samulski; Weidong Xiao
Existence of transient functional double-stranded DNA intermediates during recombinant AAV transduction.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(32):13104-9.
2007: Joshua C Grieger; Jarrod S Johnson; Brittney Gurda-Whitaker; Mavis Agbandje-McKenna; R Jude Samulski
Surface-exposed adeno-associated virus Vp1-NLS capsid fusion protein rescues infectivity of noninfectious wild-type Vp2/Vp3 and Vp3-only capsids but not that of fivefold pore mutant virions.
Journal of virology 2007;81(15):7833-43.
2007: Katsutoshi Yokoi; Shu Kachi; H Steve Zhang; Philip D Gregory; S Kaye Spratt; R Jude Samulski; Peter A Campochiaro
Ocular gene transfer with self-complementary AAV vectors.
Investigative ophthalmology & visual science 2007;48(7):3324-8.
2007: Chengwen Li; Matthew Hirsch; Aravind Asokan; Brian Zeithaml; Hong Ma; Tal Kafri; R Jude Samulski
Adeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivo.
Journal of virology 2007;81(14):7540-7.
2007: Benjamin W Maynor; Isaac LaRue; Zhaokang Hu; Jason P Rolland; Ashish Pandya; Qiang Fu; Jie Liu; Richard J Spontak; Sergei S Sheiko; R Jude Samulski; Edward T Samulski; Joseph M DeSimone
Supramolecular nanomimetics: replication of micelles, viruses, and other naturally occurring nanoscale objects.
Small (Weinheim an der Bergstrasse, Germany) 2007;3(5):845-9.
2007: Vivian W Choi; Aravind Asokan; Rebecca A Haberman; R Jude Samulski
Production of recombinant adeno-associated viral vectors.
Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] 2007;Chapter 12():Unit 12.9.
2007: Vivian W Choi; Aravind Asokan; Rebecca A Haberman; R Jude Samulski
Production of recombinant adeno-associated viral vectors for in vitro and in vivo use.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2007;Chapter 16():Unit 16.25.
2006: Vivian W Choi; Douglass Mccarty; R Jude Samulski
Host cell DNA repair pathways in adeno-associated viral genome processing.
Journal of virology 2006;80(21):10346-56.
2006: Zhijian Wu; Aravind Asokan; Joshua C Grieger; Lakshmanan Govindasamy; Mavis Agbandje-McKenna; R Jude Samulski
Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes.
Journal of virology 2006;80(22):11393-7.
2006: Zhijian Wu; Edward Miller; Mavis Agbandje-McKenna; R Jude Samulski
Alpha2,3 and alpha2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6.
Journal of virology 2006;80(18):9093-103.
2006: Aravind Asokan; Julie B Hamra; Lakshmanan Govindasamy; Mavis Agbandje-McKenna; R Jude Samulski
Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry.
Journal of virology 2006;80(18):8961-9.
2006: Zhijian Wu; Aravind Asokan; R Jude Samulski
Adeno-associated virus serotypes: vector toolkit for human gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(3):316-27.
2006: R J Hajjar; R Jude Samulski
Heart failure: a silver bullet to treat heart failure.
Gene therapy 2006;13(13):997.
2006: Joshua C Grieger; Stephen Snowdy; R Jude Samulski
Separate basic region motifs within the adeno-associated virus capsid proteins are essential for infectivity and assembly.
Journal of virology 2006;80(11):5199-210.
2006: Vivian W Choi; Aravind Asokan; Rebecca A Haberman; Thomas J McCown; R Jude Samulski
Production of recombinant adeno-associated viral vectors and use for in vitro and in vivo administration.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2006;Chapter 4():Unit 4.17.
2006: S W J McPhee; Christopher G Janson; C Li; R Jude Samulski; A S Camp; Jeremy Francis; David Shera; L Lioutermann; M Feely; Andrew Freese; Paola Leone
Immune responses to AAV in a phase I study for Canavan disease.
The journal of gene medicine 2006;8(5):577-88.
2006: Teresa Borrás; Wei Xue; Vivian W Choi; Jeffrey S Bartlett; Guorong Li; R Jude Samulski; Sarah S Chisolm
Mechanisms of AAV transduction in glaucoma-associated human trabecular meshwork cells.
The journal of gene medicine 2006;8(5):589-602.
2006: Thorsten G Lehmann; Tom Luedde; Robert F Schwabe; Hartwig Bunzendahl; R Jude Samulski; John J Lemasters; David A Brenner
Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2006;12(4):550-9.
2006: Aravind Asokan; R Jude Samulski
AAV does the shuffle.
Nature biotechnology 2006;24(2):158-60.
2006: Joshua C Grieger; Vivian W Choi; R Jude Samulski
Production and characterization of adeno-associated viral vectors.
Nature protocols 2006;1(3):1412-28.
2005: Chengwen Li; Dawn E Bowles; Terry Van Dyke; R Jude Samulski
Adeno-associated virus vectors: potential applications for cancer gene therapy.
Cancer gene therapy 2005;12(12):913-25.
2005: Ulrich T Hacker; Lisa Wingenfeld; David M Kofler; Natascha K Schuhmann; Sandra Lutz; Tobias Herold; Susan B S King; Franz M Gerner; Luca Perabo; Joseph Rabinowitz; Douglass Mccarty; R Jude Samulski; Michael Hallek; Hildegard Büning
Adeno-associated virus serotypes 1 to 5 mediated tumor cell directed gene transfer and improvement of transduction efficiency.
The journal of gene medicine 2005;7(11):1429-38.
2005: Joshua C Grieger; R Jude Samulski
Packaging capacity of adeno-associated virus serotypes: impact of larger genomes on infectivity and postentry steps.
Journal of virology 2005;79(15):9933-44.
2005: Vivian W Choi; Douglass Mccarty; R Jude Samulski
AAV hybrid serotypes: improved vectors for gene delivery.
Current gene therapy 2005;5(3):299-310.
2005: Vivian W Choi; R Jude Samulski; Douglass Mccarty
Effects of adeno-associated virus DNA hairpin structure on recombination.
Journal of virology 2005;79(11):6801-7.
2005: Aravind Asokan; R Jude Samulski
From crystal structure to clinic: highlights of the Tenth International Parvovirus Workshop.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(5):656-60.
2005: Chengwen Li; R Jude Samulski
Serotype-specific replicating AAV helper constructs increase recombinant AAV type 2 vector production.
Virology 2005;335(1):10-21.
2005: Dong Xu; Douglass Mccarty; Alda Fernandes; Michael Fisher; R Jude Samulski; Rudy L Juliano
Delivery of MDR1 small interfering RNA by self-complementary recombinant adeno-associated virus vector.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(4):523-30.
2005: A Flierl; Y Chen; Pinar E Coskun; R Jude Samulski; Douglas C Wallace
Adeno-associated virus-mediated gene transfer of the heart/muscle adenine nucleotide translocator (ANT) in mouse.
Gene therapy 2005;12(7):570-8.
2005: Hiromu Ito; Mette Koefoed; Prarop Tiyapatanaputi; Kirill Gromov; J Jeffrey Goater; Jonathan Carmouche; Xinping Zhang; Paul T Rubery; Joseph Rabinowitz; R Jude Samulski; Takashi Nakamura; Kjeld Soballe; Regis J O'Keefe; Brendan F Boyce; Edward M Schwarz
Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy.
Nature medicine 2005;11(3):291-7.
2005: Sifeng Chen; Matthias H Kapturczak; Scott A Loiler; Sergei Zolotukhin; Olena Y Glushakova; Kirsten M Madsen; R Jude Samulski; William W Hauswirth; Martha Campbell-Thompson; Kenneth I Berns; Terence R Flotte; Mark A Atkinson; C Craig Tisher; Anupam Agarwal
Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors.
Human gene therapy 2005;16(2):235-47.
2005: Joshua C Grieger; R Jude Samulski
Adeno-associated virus as a gene therapy vector: vector development, production and clinical applications.
Advances in biochemical engineering/biotechnology 2005;99():119-45.
2004: Atsuko Negishi; Jinghua Chen; Douglass Mccarty; R Jude Samulski; Jian Liu; Joy van Baren
Analysis of the interaction between adeno-associated virus and heparan sulfate using atomic force microscopy.
Glycobiology 2004;14(11):969-77.
2004: Lingling Du; Masakuni Kido; Darwin Lee; Joseph E Rabinowitz; R Jude Samulski; Stuart W Jamieson; Matthew D Weitzman; Patricia A Thistlethwaite
Differential myocardial gene delivery by recombinant serotype-specific adeno-associated viral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(3):604-8.
2004: Joseph E Rabinowitz; Dawn E Bowles; Susan M Faust; Julie G Ledford; Scott E Cunningham; R Jude Samulski
Cross-dressing the virion: the transcapsidation of adeno-associated virus serotypes functionally defines subgroups.
Journal of virology 2004;78(9):4421-32.
2004: Pierre Chenuaud; Thibaut Larcher; Joseph E Rabinowitz; Nathalie Provost; Yan Cherel; Nicole Casadevall; R Jude Samulski; Philippe Moullier
Autoimmune anemia in macaques following erythropoietin gene therapy.
Blood 2004;103(9):3303-4.
2004: Pierre Chenuaud; Thibaut Larcher; Joseph E Rabinowitz; Nathalie Provost; Béatrice Joussemet; Hermann Bujard; R Jude Samulski; David Favre; Philippe Moullier
Optimal design of a single recombinant adeno-associated virus derived from serotypes 1 and 2 to achieve more tightly regulated transgene expression from nonhuman primate muscle.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(3):410-8.
2004: Jackie L Stilwell; R Jude Samulski
Role of viral vectors and virion shells in cellular gene expression.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(3):337-46.
2004: Douglass Mccarty; Samuel M Young; R Jude Samulski
Integration of adeno-associated virus (AAV) and recombinant AAV vectors.
Annual review of genetics 2004;38():819-45.
2003: Haiyan Fu; Joseph Muenzer; R Jude Samulski; George R Breese; Jerillyn Sifford; Xinhua Zeng; Douglass Mccarty
Self-complementary adeno-associated virus serotype 2 vector: global distribution and broad dispersion of AAV-mediated transgene expression in mouse brain.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(6):911-7.
2003: Douglass Mccarty; Haiyan Fu; Paul E Monahan; C E Toulson; P Naik; R Jude Samulski
Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo.
Gene therapy 2003;10(26):2112-8.
2003: Jackie L Stilwell; Douglass Mccarty; Atsuko Negishi; Joy van Baren; R Jude Samulski
Development and characterization of novel empty adenovirus capsids and their impact on cellular gene expression.
Journal of virology 2003;77(23):12881-5.
2003: Michael D Wheeler; Olivia M Smutney; R Jude Samulski
Secretion of extracellular superoxide dismutase from muscle transduced with recombinant adenovirus inhibits the growth of B16 melanomas in mice.
Molecular cancer research : MCR 2003;1(12):871-81.
2003: Rebecca P Haberman; R Jude Samulski; Thomas J McCown
Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion.
Nature medicine 2003;9(8):1076-80.
2003: Thorsten G Lehmann; Michael D Wheeler; Matthias Froh; Robert F Schwabe; Hartwig Bunzendahl; R Jude Samulski; John J Lemasters; David A Brenner; Ronald G Thurman
Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat.
Transplantation 2003;76(1):28-37.
2003: Terry J Amiss; Douglass Mccarty; Anna Skulimowski; R Jude Samulski
Identification and characterization of an adeno-associated virus integration site in CV-1 cells from the African green monkey.
Journal of virology 2003;77(3):1904-15.
2003: R Jude Samulski
AAV vectors, the future workhorse of human gene therapy.
Ernst Schering Research Foundation workshop 2003;(43):25-40.
2003: Jackie L Stilwell; R Jude Samulski
Adeno-associated virus vectors for therapeutic gene transfer.
BioTechniques 2003;34(1):148-50, 152, 154 passim.
2003: Matthew D Weitzman; Samuel M Young; Toni Cathomen; R Jude Samulski
Targeted integration by adeno-associated virus.
Methods in molecular medicine 2003;76():201-19.
2003: Dawn E Bowles; Joseph E Rabinowitz; R Jude Samulski
Marker rescue of adeno-associated virus (AAV) capsid mutants: a novel approach for chimeric AAV production.
Journal of virology 2003;77(1):423-32.
2002: Karen McAllister; Peter Sazani; Mirielle Adam; Moo Je Cho; Michael Rubinstein; R Jude Samulski; Joseph M DeSimone
Polymeric nanogels produced via inverse microemulsion polymerization as potential gene and antisense delivery agents.
Journal of the American Chemical Society 2002;124(51):15198-207.
2002: Joseph E Rabinowitz; R Jude Samulski
Vector biophysics: crystal-clear view.
Gene therapy 2002;9(21):1413-4.
2002: Rebecca P Haberman; Hugh E Criswell; Stephen Snowdy; Zhen Ming; George R Breese; R Jude Samulski; Thomas J McCown
Therapeutic liabilities of in vivo viral vector tropism: adeno-associated virus vectors, NMDAR1 antisense, and focal seizure sensitivity.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(4):495-500.
2002: Joseph E Rabinowitz; R Jude Samulski
The adeno-associated virus crystal: impact inversely proportional to size.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(4):443-5.
2002: Haiyan Fu; R Jude Samulski; Thomas J McCown; Yoana J Picornell; David Fletcher; Joseph Muenzer
Neurological correction of lysosomal storage in a mucopolysaccharidosis IIIB mouse model by adeno-associated virus-mediated gene delivery.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(1):42-9.
2002: Joseph E Rabinowitz; Fabienne Rolling; Chengwen Li; Hervé Conrath; Weidong Xiao; Xiao Xiao; R Jude Samulski
Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity.
Journal of virology 2002;76(2):791-801.
2001: Michael D Wheeler; Hiroshi Kono; M Yin; M Nakagami; Takehiko Uesugi; Gavin E Arteel; Erwin Gäbele; Ivan Rusyn; S Yamashina; Matthias Froh; Y Adachi; Yuji Iimuro; Blair U Bradford; Olivia M Smutney; Henry D Connor; Ronald P Mason; Sanna Goyert; J M Peters; F J Gonzalez; R Jude Samulski; Ronald G Thurman
The role of Kupffer cell oxidant production in early ethanol-induced liver disease.
Free radical biology & medicine 2001;31(12):1544-9.
2001: Michael D Wheeler; M Katuna; Olivia M Smutney; Matthias Froh; Anna Dikalova; Ronald P Mason; R Jude Samulski; Ronald G Thurman
Comparison of the effect of adenoviral delivery of three superoxide dismutase genes against hepatic ischemia-reperfusion injury.
Human gene therapy 2001;12(18):2167-77.
2001: M Yin; Michael D Wheeler; Henry D Connor; Zhi Zhong; Hartwig Bunzendahl; Anna Dikalova; R Jude Samulski; Robert Schoonhoven; R P Mason; James A Swenberg; Ronald G Thurman
Cu/Zn-superoxide dismutase gene attenuates ischemia-reperfusion injury in the rat kidney.
Journal of the American Society of Nephrology : JASN 2001;12(12):2691-700.
2001: Samuel M Young; R Jude Samulski
Adeno-associated virus (AAV) site-specific recombination does not require a Rep-dependent origin of replication within the AAV terminal repeat.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13525-30.
2001: Hengjun Chao; Paul E Monahan; Y Liu; R Jude Samulski; Christopher E Walsh
Sustained and complete phenotype correction of hemophilia B mice following intramuscular injection of AAV1 serotype vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(3):217-22.
2001: Douglass Mccarty; Paul E Monahan; R Jude Samulski
Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis.
Gene therapy 2001;8(16):1248-54.
2001: Michael D Wheeler; Hiroshi Kono; M Yin; Ivan Rusyn; Matthias Froh; Henry D Connor; Ronald P Mason; R Jude Samulski; Ronald G Thurman
Delivery of the Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats.
Gastroenterology 2001;120(5):1241-50.
2001: T J Amiss; R Jude Samulski
Methods for adeno-associated virus-mediated gene transfer into muscle.
Methods in molecular biology (Clifton, N.J.) 2001;175():455-69.
2000: Joseph E Rabinowitz; R Jude Samulski
Building a better vector: the manipulation of AAV virions.
Virology 2000;278(2):301-8.
2000: Hengjun Chao; Y Liu; J Rabinowitz; Chengwen Li; R Jude Samulski; Christopher E Walsh
Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(6):619-23.
2000: Paul E Monahan; R Jude Samulski
Adeno-associated virus vectors for gene therapy: more pros than cons?
Molecular medicine today 2000;6(11):433-40.
2000: Michael D Wheeler; Hiroshi Kono; Ivan Rusyn; Gavin E Arteel; Douglass Mccarty; R Jude Samulski; Ronald G Thurman
Chronic ethanol increases adeno-associated viral transgene expression in rat liver via oxidant and NFkappaB-dependent mechanisms.
Hepatology (Baltimore, Md.) 2000;32(5):1050-9.
2000: Rebecca P Haberman; Thomas J McCown; R Jude Samulski
Novel transcriptional regulatory signals in the adeno-associated virus terminal repeat A/D junction element.
Journal of virology 2000;74(18):8732-9.
2000: P J Carter; R Jude Samulski
Adeno-associated viral vectors as gene delivery vehicles.
International journal of molecular medicine 2000;6(1):17-27.
2000: R Jude Samulski
Expanding the AAV package.
Nature biotechnology 2000;18(5):497-8.
2000: Samuel M Young; Douglass Mccarty; Natasha P Degtyareva; R Jude Samulski
Roles of adeno-associated virus Rep protein and human chromosome 19 in site-specific recombination.
Journal of virology 2000;74(9):3953-66.
2000: Ajay K Malik; Paul E Monahan; David L Allen; B G Chen; R Jude Samulski; Kotoku Kurachi
Kinetics of recombinant adeno-associated virus-mediated gene transfer.
Journal of virology 2000;74(8):3555-65.
2000: Thorsten G Lehmann; Michael D Wheeler; Robert Schoonhoven; Hartwig Bunzendahl; R Jude Samulski; Ronald G Thurman
Delivery of Cu/Zn-superoxide dismutase genes with a viral vector minimizes liver injury and improves survival after liver transplantation in the rat.
Transplantation 2000;69(6):1051-7.
2000: R Pruchnic; B Cao; Z Q Peterson; Xiao Xiao; J Li; R Jude Samulski; M Epperly; J Huard
The use of adeno-associated virus to circumvent the maturation-dependent viral transduction of muscle fibers.
Human gene therapy 2000;11(4):521-36.
2000: Jeffrey S Bartlett; R Wilcher; R Jude Samulski
Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors.
Journal of virology 2000;74(6):2777-85.
2000: Paul E Monahan; R Jude Samulski
AAV vectors: is clinical success on the horizon?
Gene therapy 2000;7(1):24-30.
2000: Samuel M Young; Weidong Xiao; R Jude Samulski
Site-specific targeting of DNA plasmids to chromosome 19 using AAV cis and trans sequences.
Methods in molecular biology (Clifton, N.J.) 2000;133():111-26.
1999: Joseph E Rabinowitz; Weidong Xiao; R Jude Samulski
Insertional mutagenesis of AAV2 capsid and the production of recombinant virus.
Virology 1999;265(2):274-85.
1999: D K Gavin; Samuel M Young; Weidong Xiao; Brenda Temple; C R Abernathy; DJ Pereira; Nicholas Muzyczka; R Jude Samulski
Charge-to-alanine mutagenesis of the adeno-associated virus type 2 Rep78/68 proteins yields temperature-sensitive and magnesium-dependent variants.
Journal of virology 1999;73(11):9433-45.
1999: Hengjun Chao; R Jude Samulski; Dwight A Bellinger; Paul E Monahan; Timothy C Nichols; Christopher E Walsh
Persistent expression of canine factor IX in hemophilia B canines.
Gene therapy 1999;6(10):1695-704.
1999: D Grimm; Andrea Kern; Michael Pawlita; F Ferrari; R Jude Samulski; Jürgen A Kleinschmidt
Titration of AAV-2 particles via a novel capsid ELISA: packaging of genomes can limit production of recombinant AAV-2.
Gene therapy 1999;6(7):1322-30.
1999: Sergei Zolotukhin; Barry J Byrne; Edward Mason; Irene Zolotukhin; Mark Potter; Kye A Chesnut; C Summerford; R Jude Samulski; Nicholas Muzyczka
Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield.
Gene therapy 1999;6(6):973-85.
1999: C Summerford; R Jude Samulski
Viral receptors and vector purification: new approaches for generating clinical-grade reagents.
Nature medicine 1999;5(5):587-8.
1999: Jeffrey S Bartlett; J Kleinschmidt; Richard C Boucher; R Jude Samulski
Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab'gamma)2 antibody.
Nature biotechnology 1999;17(2):181-6.
1999: C Summerford; Jeffrey S Bartlett; R Jude Samulski
AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection.
Nature medicine 1999;5(1):78-82.
1998: Rebecca P Haberman; Thomas J McCown; R Jude Samulski
Inducible long-term gene expression in brain with adeno-associated virus gene transfer.
Gene therapy 1998;5(12):1604-11.
1998: S Teramoto; Jeffrey S Bartlett; Douglass Mccarty; Xiao Xiao; R Jude Samulski; Richard C Boucher
Factors influencing adeno-associated virus-mediated gene transfer to human cystic fibrosis airway epithelial cells: comparison with adenovirus vectors.
Journal of virology 1998;72(11):8904-12.
1998: Matthew J During; R Jude Samulski; John D Elsworth; Michael Gordon Kaplitt; Paola Leone; Xiao Xiao; J Li; Andrew Freese; Jane R Taylor; Robert H Roth; John R Sladek; Karen L O'Malley; D Eugene Redmond
In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector.
Gene therapy 1998;5(6):820-7.
1998: Jeffrey S Bartlett; R Jude Samulski; Thomas J McCown
Selective and rapid uptake of adeno-associated virus type 2 in brain.
Human gene therapy 1998;9(8):1181-6.
1998: Jeffrey S Bartlett; R Jude Samulski
Fluorescent viral vectors: a new technique for the pharmacological analysis of gene therapy.
Nature medicine 1998;4(5):635-7.
1998: Xiao Xiao; J Li; R Jude Samulski
Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus.
Journal of virology 1998;72(3):2224-32.
1998: C Summerford; R Jude Samulski
Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions.
Journal of virology 1998;72(2):1438-45.
1998: Paul E Monahan; R Jude Samulski; J Tazelaar; Xiao Xiao; Timothy C Nichols; Dwight A Bellinger; Marjorie S Read; Christopher E Walsh
Direct intramuscular injection with recombinant AAV vectors results in sustained expression in a dog model of hemophilia.
Gene therapy 1998;5(1):40-9.
1997: C C Yang; Xiao Xiao; X Zhu; D C Ansardi; N D Epstein; Mark R Frey; A Gregory Matera; R Jude Samulski
Cellular recombination pathways and viral terminal repeat hairpin structures are sufficient for adeno-associated virus integration in vivo and in vitro.
Journal of virology 1997;71(12):9231-47.
1997: F K Ferrari; Xiao Xiao; Douglass Mccarty; R Jude Samulski
New developments in the generation of Ad-free, high-titer rAAV gene therapy vectors.
Nature medicine 1997;3(11):1295-7.
1997: Stuart D Keir; J Miller; G Yu; R Hamilton; R Jude Samulski; Xiao Xiao; Carlo Tornatore
Efficient gene transfer into primary and immortalized human fetal glial cells using adeno-associated virus vectors: establishment of a glial cell line with a functional CD4 receptor.
Journal of neurovirology 1997;3(5):322-30.
1997: J Li; R Jude Samulski; Xiao Xiao
Role for highly regulated rep gene expression in adeno-associated virus vector production.
Journal of virology 1997;71(7):5236-43.
1997: Xiao Xiao; Thomas J McCown; J Li; George R Breese; A Leslie Morrow; R Jude Samulski
Adeno-associated virus (AAV) vector antisense gene transfer in vivo decreases GABA(A) alpha1 containing receptors and increases inferior collicular seizure sensitivity.
Brain research 1997;756(1-2):76-83.
1997: Xiao Xiao; J Li; Thomas J McCown; R Jude Samulski
Gene transfer by adeno-associated virus vectors into the central nervous system.
Experimental neurology 1997;144(1):113-24.
1997: Xiao Xiao; Weidong Xiao; J Li; R Jude Samulski
A novel 165-base-pair terminal repeat sequence is the sole cis requirement for the adeno-associated virus life cycle.
Journal of virology 1997;71(2):941-8.
1996: Michael Gordon Kaplitt; Xiao Xiao; R Jude Samulski; J Li; Kaie Ojamaa; I L Klein; H Makimura; M J Kaplitt; R K Strumpf; E B Diethrich
Long-term gene transfer in porcine myocardium after coronary infusion of an adeno-associated virus vector.
The Annals of thoracic surgery 1996;62(6):1669-76.
1996: Xiao Xiao; J Li; R Jude Samulski
Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector.
Journal of virology 1996;70(11):8098-108.
1996: C McKeon; R Jude Samulski
NIDDK Workshop on AAV Vectors: Gene Transfer into Quiescent Cells.
Human gene therapy 1996;7(13):1615-9.
1996: Jeffrey S Bartlett; M Sethna; L Ramamurthy; S A Gowen; R Jude Samulski; William F Marzluff
Efficient expression of protein coding genes from the murine U1 small nuclear RNA promoters.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):8852-7.
1996: F K Ferrari; T Samulski; Thomas Shenk; R Jude Samulski
Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors.
Journal of virology 1996;70(5):3227-34.
1996: Thomas J McCown; Xiao Xiao; J Li; George R Breese; R Jude Samulski
Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector.
Brain research 1996;713(1-2):99-107.
1996: Douglass Mccarty; R Jude Samulski
Adeno-associated virus vectors for gene transfer into erythroid cells.
Current topics in microbiology and immunology 1996;218():75-91.
1995: F Rolling; R Jude Samulski
AAV as a viral vector for human gene therapy. Generation of recombinant virus.
Molecular biotechnology 1995;3(1):9-15.
1994: J L Miller; Robert E Donahue; Stephanie Sellers; R Jude Samulski; Neal S Young; A W Nienhuis
Recombinant adeno-associated virus (rAAV)-mediated expression of a human gamma-globin gene in human progenitor-derived erythroid cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(21):10183-7.
1994: Christopher E Walsh; A W Nienhuis; R Jude Samulski; M G Brown; J L Miller; Neal S Young; Johnson Ming-Yu Liu
Phenotypic correction of Fanconi anemia in human hematopoietic cells with a recombinant adeno-associated virus vector.
The Journal of clinical investigation 1994;94(4):1440-8.
1994: Michael Gordon Kaplitt; Paola Leone; R Jude Samulski; Xiao Xiao; Donald Pfaff; Karen L O'Malley; Matthew J During
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain.
Nature genetics 1994;8(2):148-54.
1994: S Goodman; Xiaodong Xiao; Robert E Donahue; A Moulton; J Miller; Christopher E Walsh; Neal S Young; R Jude Samulski; A W Nienhuis
Recombinant adeno-associated virus-mediated gene transfer into hematopoietic progenitor cells.
Blood 1994;84(5):1492-500.
1994: J F Wei; F S Wei; R Jude Samulski; John A Barranger
Expression of the human glucocerebrosidase and arylsulfatase A genes in murine and patient primary fibroblasts transduced by an adeno-associated virus vector.
Gene therapy 1994;1(4):261-8.
1993: Christopher E Walsh; Johnson Ming-Yu Liu; J L Miller; A W Nienhuis; R Jude Samulski
Gene therapy for human hemoglobinopathies.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1993;204(3):289-300.
1993: R O Snyder; D S Im; T Ni; Xiao Xiao; R Jude Samulski; Nicholas Muzyczka
Features of the adeno-associated virus origin involved in substrate recognition by the viral Rep protein.
Journal of virology 1993;67(10):6096-104.
1993: J L Miller; Christopher E Walsh; Paul A Ney; R Jude Samulski; A W Nienhuis
Single-copy transduction and expression of human gamma-globin in K562 erythroleukemia cells using recombinant adeno-associated virus vectors: the effect of mutations in NF-E2 and GATA-1 binding motifs within the hypersensitivity site 2 enhancer.
Blood 1993;82(6):1900-6.
1993: R Jude Samulski
Adeno-associated virus: integration at a specific chromosomal locus.
Current opinion in genetics & development 1993;3(1):74-80.
1992: Christopher E Walsh; Johnson Ming-Yu Liu; Xiaodong Xiao; Neal S Young; A W Nienhuis; R Jude Samulski
Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(15):7257-61.
1992: C A Muro-Cacho; R Jude Samulski; D Kaplan
Gene transfer in human lymphocytes using a vector based on adeno-associated virus.
Journal of immunotherapy : official journal of the Society for Biological Therapy 1992;11(4):231-7.
1992: L A Hunter; R Jude Samulski
Colocalization of adeno-associated virus Rep and capsid proteins in the nuclei of infected cells.
Journal of virology 1992;66(1):317-24.
1991: R Jude Samulski; X Zhu; Xiao Xiao; J D Brook; D E Housman; N Epstein; L A Hunter
Targeted integration of adeno-associated virus (AAV) into human chromosome 19.
The EMBO journal 1991;10(12):3941-50.
1990: robert kotin; M Siniscalco; R Jude Samulski; X D Zhu; L Hunter; C A Laughlin; S McLaughlin; Nicholas Muzyczka; M Rocchi; K I Berns
Site-specific integration by adeno-associated virus.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(6):2211-5.
1990: R O Snyder; R Jude Samulski; Nicholas Muzyczka
In vitro resolution of covalently joined AAV chromosome ends.
Cell 1990;60(1):105-13.
1989: C H Srivastava; R Jude Samulski; L Lu; S H Larsen; Arun Srivastava
Construction of a recombinant human parvovirus B19: adeno-associated virus 2 (AAV) DNA inverted terminal repeats are functional in an AAV-B19 hybrid virus.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):8078-82.
1989: R Jude Samulski; Long-sheng Chang; Thomas Shenk
Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression.
Journal of virology 1989;63(9):3822-8.
1988: R Jude Samulski; Thomas Shenk
Adenovirus E1B 55-Mr polypeptide facilitates timely cytoplasmic accumulation of adeno-associated virus mRNAs.
Journal of virology 1988;62(1):206-10.
1987: R Jude Samulski; Long-sheng Chang; Thomas Shenk
A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication.
Journal of virology 1987;61(10):3096-101.
1987: P Hearing; R Jude Samulski; W L Wishart; Thomas Shenk
Identification of a repeated sequence element required for efficient encapsidation of the adenovirus type 5 chromosome.
Journal of virology 1987;61(8):2555-8.
1984: Nicholas Muzyczka; R Jude Samulski; P Hermonat; Arun Srivastava; K I Berns
The genetics of adeno-associated virus.
Advances in experimental medicine and biology 1984;179():151-61.
1983: R Jude Samulski; Arun Srivastava; K I Berns; Nicholas Muzyczka
Rescue of adeno-associated virus from recombinant plasmids: gene correction within the terminal repeats of AAV.
Cell 1983;33(1):135-43.
1982: R Jude Samulski; K I Berns; M Tan; Nicholas Muzyczka
Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(6):2077-81.
1980: G K McMaster; R Jude Samulski; J L Stein; G S Stein
Rapid purification of covalently closed circular DNAs of bacterial plasmids and animal tumor viruses.
Analytical biochemistry 1980;109(1):47-54.