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Amram Samuni

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Chemicals & Drugs

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Publications

TOP 3
Amram Samuni; Sara Goldstein
Redox properties and thiol reactivity of geldanamycin and its analogues in aqueous solutions.
Amram Samuni; Sara Goldstein
One-electron oxidation of acetohydroxamic acid: the intermediacy of nitroxyl and peroxynitrite.
Sara Goldstein; Amram Samuni; Gabor Merenyi
Kinetics of the reaction between nitroxide and thiyl radicals: nitroxides as antioxidants in the presence of thiols.

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All Publications

2012: Amram Samuni; Sara Goldstein
Redox properties and thiol reactivity of geldanamycin and its analogues in aqueous solutions.
The journal of physical chemistry. B 2012;116(22):6404-10.
2011: Amram Samuni; Sara Goldstein
One-electron oxidation of acetohydroxamic acid: the intermediacy of nitroxyl and peroxynitrite.
The journal of physical chemistry. A 2011;115(14):3022-8.
2008: Sara Goldstein; Amram Samuni; Gabor Merenyi
Kinetics of the reaction between nitroxide and thiyl radicals: nitroxides as antioxidants in the presence of thiols.
The journal of physical chemistry. A 2008;112(37):8600-5.
2008: Seonghun Ryu; Asher Ornoy; Amram Samuni; Sarah W Zangen; Ron Kohen
Oxidative stress in Cohen diabetic rat model by high-sucrose, low-copper diet: inducing pancreatic damage and diabetes.
Metabolism: clinical and experimental 2008;57(9):1253-61.
2007: Seonghun Ryu; Ron Kohen; Amram Samuni; Asher Ornoy
Nitroxide radicals protect cultured rat embryos and yolk sacs from diabetic-induced damage.
Birth defects research. Part A, Clinical and molecular teratology 2007;79(8):604-11.
2007: Yaacov Aronovitch; Dina Godinger; Avner Israeli; Murali K Cherukuri; Amram Samuni; Sara Goldstein
Dual activity of nitroxides as pro- and antioxidants: catalysis of copper-mediated DNA breakage and H2O2 dismutation.
Free radical biology & medicine 2007;42(9):1317-25.
2007: Sara Goldstein; Amram Samuni
Kinetics and mechanism of peroxyl radical reactions with nitroxides.
The journal of physical chemistry. A 2007;111(6):1066-72.
2006: Sara Goldstein; Amram Samuni; Kálmán Hideg; Gabor Merenyi
Structure-activity relationship of cyclic nitroxides as SOD mimics and scavengers of nitrogen dioxide and carbonate radicals.
The journal of physical chemistry. A 2006;110(10):3679-85.
2005: Sara Goldstein; Amram Samuni
Intra- and intermolecular oxidation of oxymyoglobin and oxyhemoglobin induced by hydroxyl and carbonate radicals.
Free radical biology & medicine 2005;39(4):511-9.
2005: Simeng Suy; James B Mitchell; Amram Samuni; Susette Mueller; Usha N Kasid
Nitroxide tempo, a small molecule, induces apoptosis in prostate carcinoma cells and suppresses tumor growth in athymic mice.
Cancer 2005;103(6):1302-13.
2005: Avner Israeli; Miriam Patt; Miriam Oron; Amram Samuni; Ron Kohen; Sara Goldstein
Kinetics and mechanism of the comproportionation reaction between oxoammonium cation and hydroxylamine derived from cyclic nitroxides.
Free radical biology & medicine 2005;38(3):317-24.
2005: Amram Samuni; Usha N Kasid; Eric Y Chuang; Simeng Suy; William DeGraff; Murali K Cherukuri; Angelo Russo; James B Mitchell
Effects of hypoxia on radiation-responsive stress-activated protein kinase, p53, and caspase 3 signals in TK6 human lymphoblastoid cells.
Cancer research 2005;65(2):579-86.
2004: Sara Goldstein; Gabor Merenyi; Amram Samuni
Kinetics and mechanism of *NO2 reacting with various oxidation states of myoglobin.
Journal of the American Chemical Society 2004;126(48):15694-701.
2004: Amram Samuni; William DeGraff; John A Cook; Murali K Cherukuri; Angelo Russo; James B Mitchell
The effects of antioxidants on radiation-induced apoptosis pathways in TK6 cells.
Free radical biology & medicine 2004;37(10):1648-55.
2004: Ronit Lavi; Michael S Sinyakov; Amram Samuni; Smadar Shatz; Harry Friedmann; Asher Shainberg; Haim Breitbart; Rachel Lubart
ESR detection of 1O2 reveals enhanced redox activity in illuminated cell cultures.
Free radical research 2004;38(9):893-902.
2004: Yuval Samuni; Janet Gamson; Amram Samuni; Kenichi Yamada; Angelo Russo; Murali K Cherukuri; James B Mitchell
Factors influencing nitroxide reduction and cytotoxicity in vitro.
Antioxidants & redox signaling 2004;6(3):587-95.
2004: Sandhya Xavier; Ester Piek; Makiko Fujii; Delphine Javelaud; Alain Mauviel; Kathleen C Flanders; Amram Samuni; Angelina Felici; Michael Reiss; Shai Yarkoni; Anastasia L Sowers; James B Mitchell; Anita B Roberts; Angelo Russo
Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone.
The Journal of biological chemistry 2004;279(15):15167-76.
2004: Sara Goldstein; Amram Samuni; Gabor Merenyi
Reactions of nitric oxide, peroxynitrite, and carbonate radicals with nitroxides and their corresponding oxoammonium cations.
Chemical research in toxicology 2004;17(2):250-7.
2004: Amram Samuni; Yechezkel Barenholz
Use of nitroxides to protect liposomes against oxidative damage.
Methods in enzymology 2004;387():299-314.
2003: Sara Goldstein; Angelo Russo; Amram Samuni
Reactions of PTIO and carboxy-PTIO with *NO, *NO2, and O2-*.
The Journal of biological chemistry 2003;278(51):50949-55.
2003: Azik Hoffman; Sara Goldstein; Amram Samuni; Joseph B Borman; Herzl Schwalb
Effect of nitric oxide and nitroxide SOD-mimic on the recovery of isolated rat heart following ischemia and reperfusion.
Biochemical pharmacology 2003;66(7):1279-86.
2003: Ziva Lurie; Tal Offer; Angelo Russo; Amram Samuni; Dorrit Nitzan
Do stable nitroxide radicals catalyze or inhibit the degradation of hyaluronic acid?
Free radical biology & medicine 2003;35(2):169-78.
2003: Sara Goldstein; Amram Samuni; Angelo Russo
Reaction of cyclic nitroxides with nitrogen dioxide: the intermediacy of the oxoammonium cations.
Journal of the American Chemical Society 2003;125(27):8364-70.
2003: Amram Samuni; Eric Y Chuang; Murali K Cherukuri; William Stein; William DeGraff; Angelo Russo; James B Mitchell
Semiquinone radical intermediate in catecholic estrogen-mediated cytotoxicity and mutagenesis: chemoprevention strategies with antioxidants.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5390-5.
2003: Sara Goldstein; Gabor Merenyi; Angelo Russo; Amram Samuni
The role of oxoammonium cation in the SOD-mimic activity of cyclic nitroxides.
Journal of the American Chemical Society 2003;125(3):789-95.
2003: Amram Samuni; Yechezkel Barenholz
Site-activity relationship of nitroxide radical's antioxidative effect.
Free radical biology & medicine 2003;34(2):177-85.
2002: Sandhya Xavier; Ken-ichi Yamada; Amram Samuni; Amram Samuni; William DeGraff; Murali K Cherukuri; James B Mitchell
Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage.
Biochimica et biophysica acta 2002;1573(2):109-20.
2002: Geetha Thiagarajan; Sushil Chandani; Sithamraju Harinarayana Rao; Amram Samuni; Krish Chandrasekaran; Dorairajan Balasubramanian
Molecular and cellular assessment of ginkgo biloba extract as a possible ophthalmic drug.
Experimental eye research 2002;75(4):421-30.
2002: Amram Samuni; Sara Goldstein; Angelo Russo; James B Mitchell; Murali K Cherukuri; Pedatsur Neta
Kinetics and mechanism of hydroxyl radical and OH-adduct radical reactions with nitroxides and with their hydroxylamines.
Journal of the American Chemical Society 2002;124(29):8719-24.
2002: Amram Samuni; Murali K Cherukuri; William DeGraff; Angelo Russo; Roy P Planalp; Martin W Brechbiel; James B Mitchell
Mechanisms underlying the cytotoxic effects of Tachpyr--a novel metal chelator.
Biochimica et biophysica acta 2002;1571(3):211-8.
2002: Amram Samuni; William DeGraff; Murali K Cherukuri; James B Mitchell
Nitroxides as antioxidants: Tempol protects against EO9 cytotoxicity.
Molecular and cellular biochemistry 2002;234-235(1-2):327-33.
2002: Sara Goldstein; Amram Samuni; Yaacov Aronovitch; Dina Godinger; Angelo Russo; James B Mitchell
Kinetics of paraquat and copper reactions with nitroxides: the effects of nitroxides on the aerobic and anoxic toxicity of paraquat.
Chemical research in toxicology 2002;15(5):686-91.
2002: Galina Zeltcer; Eduard Berenshtein; Nahum Kitrossky; Mordechai Chevion; Amram Samuni
Time window of nitroxide effect on myocardial ischemic-reperfusion injury potentiated by iron.
Free radical biology & medicine 2002;32(9):912-9.
2002: Tal Offer; Amram Samuni
Nitroxides inhibit peroxyl radical-mediated DNA scission and enzyme inactivation.
Free radical biology & medicine 2002;32(9):872-81.
2002: Gidon Czapski; Amram Samuni; Sara Goldstein
Superoxide dismutase mimics: antioxidative and adverse effects.
Methods in enzymology 2002;349():234-42.
2001: Amram Samuni; William DeGraff; Murali K Cherukuri; James B Mitchell
Cellular sites of H2O2-induced damage and their protection by nitroxides.
Biochimica et biophysica acta 2001;1525(1-2):70-6.
2001: Amram Samuni; M Afeworki; William Stein; Alexander T Yordanov; William DeGraff; Murali K Cherukuri; James B Mitchell; Martin W Brechbiel
Multifunctional antioxidant activity of HBED iron chelator.
Free radical biology & medicine 2001;30(2):170-7.
2000: Tal Offer; Angelo Russo; Amram Samuni
The pro-oxidative activity of SOD and nitroxide SOD mimics.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(9):1215-23.
2000: Amram Samuni; A Lipman; Yechezkel Barenholz
Damage to liposomal lipids: protection by antioxidants and cholesterol-mediated dehydration.
Chemistry and physics of lipids 2000;105(2):121-34.
1999: Dinorah Barasch; O Zipori; Israel Ringel; Isaac Ginsburg; Amram Samuni; Jehoshua Katzhendler
Novel anthraquinone derivatives with redox-active functional groups capable of producing free radicals by metabolism: are free radicals essential for cytotoxicity?
European journal of medicinal chemistry 1999;34(7-8):597-615.
1999: E Zamir; R Zhang; Amram Samuni; M Kogan; Jacob Pe'er
Nitroxide stable radical suppresses autoimmune uveitis in rats.
Free radical biology & medicine 1999;27(1-2):7-15.
1999: R Zhang; Sara Goldstein; Amram Samuni
Kinetics of superoxide-induced exchange among nitroxide antioxidants and their oxidized and reduced forms.
Free radical biology & medicine 1999;26(9-10):1245-52.
1999: Amram Samuni; Fanny Karmeli; M Moshen; Daniel Rachmilewitz
Mechanisms underlying gastric antiulcerative activity of nitroxides in rats.
Free radical research 1999;30(2):133-40.
1998: Tal Offer; M Mohsen; Amram Samuni
An SOD-mimicry mechanism underlies the role of nitroxides in protecting papain from oxidative inactivation.
Free radical biology & medicine 1998;25(7):832-8.
1998: R Zhang; Esther Shohami; Elie Beit-Yannai; R Bass; Victoria Trembovler; Amram Samuni
Mechanism of brain protection by nitroxide radicals in experimental model of closed-head injury.
Free radical biology & medicine 1998;24(2):332-40.
1998: R Zhang; A Pinson; Amram Samuni
Both hydroxylamine and nitroxide protect cardiomyocytes from oxidative stress.
Free radical biology & medicine 1998;24(1):66-75.
1997: G Zeltcer; Eduard Berenshtein; Amram Samuni; Mordechai Chevion
Nitroxide radicals prevent metal-aggravated reperfusion injury in isolated rat heart.
Free radical research 1997;27(6):627-35.
1997: Amram Samuni; Yechezkel Barenholz; Daniel Crommelin; NJ Zuidam
Gamma-irradiation damage to liposomes differing in composition and their protection by nitroxides.
Free radical biology & medicine 1997;23(7):972-9.
1997: Amram Samuni; Yechezkel Barenholz
Stable nitroxide radicals protect lipid acyl chains from radiation damage.
Free radical biology & medicine 1997;22(7):1165-74.
1996: Murali K Cherukuri; A Russo; J B Mitchell; S Goldstein; H Dafni; Amram Samuni
Do nitroxide antioxidants act as scavengers of O2-. or as SOD mimics?
The Journal of biological chemistry 1996;271(42):26026-31.
1996: Murali K Cherukuri; Amram Samuni; J Taira; S Goldstein; James B Mitchell; Angelo Russo
Stimulation by nitroxides of catalase-like activity of hemeproteins. Kinetics and mechanism.
The Journal of biological chemistry 1996;271(42):26018-25.
1996: Elie Beit-Yannai; R Zhang; Victoria Trembovler; Amram Samuni; Esther Shohami
Cerebroprotective effect of stable nitroxide radicals in closed head injury in the rat.
Brain research 1996;717(1-2):22-8.
1996: G Wang; D Godinger; J Aronovitch; Amram Samuni
Opposing effects of nitroxide free radicals in Escherichia coli mutants deficient in DNA repair.
Biochimica et biophysica acta 1996;1305(1-2):71-8.
1995: R Pacelli; David A Wink; John A Cook; Murali K Cherukuri; William DeGraff; N Friedman; M Tsokos; Amram Samuni; James B Mitchell
Nitric oxide potentiates hydrogen peroxide-induced killing of Escherichia coli.
The Journal of experimental medicine 1995;182(5):1469-79.
1995: M Mohsen; A Pinson; R Zhang; Amram Samuni
Do nitroxides protect cardiomyocytes from hydrogen peroxide or superoxide?
Molecular and cellular biochemistry 1995;145(2):103-10.
1994: Murali K Cherukuri; R F Halevy; R Zhang; Peter L Gutierrez; Amram Samuni
Modulation of streptonigrin cytotoxicity by nitroxide SOD mimics.
Free radical biology & medicine 1994;17(5):379-88.
1994: R Zhang; O Hirsch; M Mohsen; Amram Samuni
Effects of nitroxide stable radicals on juglone cytotoxicity.
Archives of biochemistry and biophysics 1994;312(2):385-91.
1994: Stephen M Hahn; Murali K Cherukuri; Amram Samuni; William DeGraff; D O Cuscela; P Johnstone; James B Mitchell
Potential use of nitroxides in radiation oncology.
Cancer research 1994;54(7 Suppl):2006s-2010s.
1994: Murali K Cherukuri; Mark Dewhirst; H S Friedman; J A Cook; William DeGraff; Amram Samuni; A Russo; J B Mitchell
Hyperthermic sensitization by the radical initiator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH). I. In vitro studies.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1994;10(2):271-81.
1994: Murali K Cherukuri; Amram Samuni
Nitroxides as antioxidants.
Methods in enzymology 1994;234():580-9.
1993: Yechezkel Barenholz; S Amselem; Dorit Goren; R Cohen; D Gelvan; Amram Samuni; E B Golden; Alberto Gabizon
Stability of liposomal doxorubicin formulations: problems and prospects.
Medicinal research reviews 1993;13(4):449-91.
1993: Murali K Cherukuri; Amram Samuni
The effect of oxygen at physiological levels on the detection of free radical intermediates by electron paramagnetic resonance.
Free radical research communications 1993;18(4):239-47.
1992: Stephen M Hahn; L Wilson; Murali K Cherukuri; J Liebmann; William DeGraff; Janet Gamson; Amram Samuni; David Venzon; James B Mitchell
Identification of nitroxide radioprotectors.
Radiation research 1992;132(1):87-93.
1992: Murali K Cherukuri; D A Grahame; Amram Samuni; James B Mitchell; Angelo Russo
Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5537-41.
1992: Stephen M Hahn; Z Tochner; Murali K Cherukuri; J Glass; L Wilson; Amram Samuni; M Sprague; David Venzon; E Glatstein; James B Mitchell
Tempol, a stable free radical, is a novel murine radiation protector.
Cancer research 1992;52(7):1750-3.
1991: Murali K Cherukuri; William DeGraff; S Tamura; Frank J Gonzalez; Amram Samuni; Angelo Russo; James B Mitchell
Mechanisms of hypoxic and aerobic cytotoxicity of mitomycin C in Chinese hamster V79 cells.
Cancer research 1991;51(24):6622-8.
1991: James B Mitchell; William DeGraff; D Kaufman; Murali K Cherukuri; Amram Samuni; E Finkelstein; M S Ahn; Stephen M Hahn; Janet Gamson; Angelo Russo
Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol.
Archives of biochemistry and biophysics 1991;289(1):62-70.
1991: Stephen M Hahn; Murali K Cherukuri; Amram Samuni; James B Mitchell; Angelo Russo
Mn(III)-desferrioxamine superoxide dismutase-mimic: alternative modes of action.
Archives of biochemistry and biophysics 1991;288(1):215-9.
1991: H Pogrebniak; W Matthews; J Mitchell; Angelo Russo; Amram Samuni; Harvey I Pass
Spin trap protection from tumor necrosis factor cytotoxicity.
The Journal of surgical research 1991;50(5):469-74.
1991: Amram Samuni; D Winkelsberg; A Pinson; Stephen M Hahn; James B Mitchell; Angelo Russo
Nitroxide stable radicals protect beating cardiomyocytes against oxidative damage.
The Journal of clinical investigation 1991;87(5):1526-30.
1991: C D Black; Amram Samuni; John A Cook; Murali K Cherukuri; D C Kaufman; H L Malech; Angelo Russo
Kinetics of superoxide production by stimulated neutrophils.
Archives of biochemistry and biophysics 1991;286(1):126-31.
1991: Amram Samuni; D Godinger; J Aronovitch; Angelo Russo; James B Mitchell
Nitroxides block DNA scission and protect cells from oxidative damage.
Biochemistry 1991;30(2):555-61.
1991: Amram Samuni; Murali K Cherukuri; J Cook; C D Black; Angelo Russo
On radical production by PMA-stimulated neutrophils as monitored by luminol-amplified chemiluminescence.
Free radical biology & medicine 1991;10(5):305-13.
1991: C D Black; John A Cook; Angelo Russo; Amram Samuni
Superoxide production by stimulated neutrophils: temperature effect.
Free radical research communications 1991;12-13 Pt 1():27-37.
1991: Amram Samuni; James B Mitchell; William DeGraff; Murali K Cherukuri; U Samuni; Angelo Russo
Nitroxide SOD-mimics: modes of action.
Free radical research communications 1991;12-13 Pt 1():187-94.
1990: D Gelvan; E Berg; P Saltman; Amram Samuni
Time-dependent modifications of ferric-adriamycin.
Biochemical pharmacology 1990;39(8):1289-95.
1990: James B Mitchell; Amram Samuni; Murali K Cherukuri; William DeGraff; M S Ahn; U Samuni; Angelo Russo
Biologically active metal-independent superoxide dismutase mimics.
Biochemistry 1990;29(11):2802-7.
1990: Amram Samuni; A Min; Murali K Cherukuri; James B Mitchell; Angelo Russo
SOD-like activity of 5-membered ring nitroxide spin labels.
Advances in experimental medicine and biology 1990;264():85-92.
1990: Amram Samuni; Murali K Cherukuri; James B Mitchell; C R Collins; Angelo Russo
Superoxide reaction with nitroxides.
Free radical research communications 1990;9(3-6):241-9.
1989: A Sion; Amram Samuni; Mordechai Chevion
Mechanistic aspects of paraquat toxicity in E. coli. A spin trapping study.
Biochemical pharmacology 1989;38(22):3903-7.
1989: A E Alegria; Amram Samuni; James B Mitchell; Péter Riesz; Angelo Russo
Free radicals induced by adriamycin-sensitive and adriamycin-resistant cells: a spin-trapping study.
Biochemistry 1989;28(21):8653-8.
1989: Amram Samuni; A Samuni; H M Swartz
The cellular-induced decay of DMPO spin adducts of .OH and .O2.
Free radical biology & medicine 1989;6(2):179-83.
1989: Amram Samuni; Murali K Cherukuri; Péter Riesz; E Finkelstein; Angelo Russo
Superoxide reaction with nitroxide spin-adducts.
Free radical biology & medicine 1989;6(2):141-8.
1988: Amram Samuni; Murali K Cherukuri; Péter Riesz; E Finkelstein; Angelo Russo
A novel metal-free low molecular weight superoxide dismutase mimic.
The Journal of biological chemistry 1988;263(34):17921-4.
1988: D Gelvan; Amram Samuni
Reappraisal of the association between adriamycin and iron.
Cancer research 1988;48(20):5645-9.
1988: Amram Samuni; C D Black; Murali K Cherukuri; H L Malech; E F Bernstein; Angelo Russo
Hydroxyl radical production by stimulated neutrophils reappraised.
The Journal of biological chemistry 1988;263(27):13797-801.
1987: M Lerner; Amram Samuni; Ehud Razin
Stimulation of murine cultured mast cells under anaerobic conditions: inhibition of arachidonic acid release.
Immunology letters 1987;16(2):121-4.
1987: J Aronovitch; D Godinger; Amram Samuni; Gidon Czapski
Ascorbic acid oxidation and DNA scission catalyzed by iron and copper chelates.
Free radical research communications 1987;2(4-6):241-58.
1986: D Gelvan; Amram Samuni
Cellular targets of adriamycin-induced damage in Escherichia coli.
Biochemical pharmacology 1986;35(19):3267-75.
1984: Amram Samuni; M Chevion; Gidon Czapski
Roles of copper and O(2) in the radiation-induced inactivation of T7 bacteriophage.
Radiation research 1984;99(3):562-72.
1983: Amram Samuni; J Aronovitch; D Godinger; M Chevion; Gidon Czapski
On the cytotoxicity of vitamin C and metal ions. A site-specific Fenton mechanism.
European journal of biochemistry / FEBS 1983;137(1-2):119-24.
1981: Amram Samuni; M Chevion; Gidon Czapski
Unusual copper-induced sensitization of the biological damage due to superoxide radicals.
The Journal of biological chemistry 1981;256(24):12632-5.

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