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Jaime Sancho

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Esther J Pavón; Antonio Rosal-Vela; Mercedes Zubiaur; Esther Zumaquero; Joaquin Abian; José Luis Callejas Rubio; Montserrat Carrascal; Daniela Cerezo-Wallis; Sonia García-Rodríguez; Richard Graeff; Keng Meng Khoo; Fabio Malavasi; Norberto Ortego Centeno; Jaime Sancho
Increased CD38 expression in T cells and circulating anti-CD38 IgG autoantibodies differentially correlate with distinct cytokine profiles and disease activity in systemic lupus erythematosus patients.
S Garcia-Rodriguez; P Navarro; J Orgaz-Molina; R Perandrés-López; J-C Ruiz; Jaime Sancho; E Zumaquero; S Arias-Santiago; Agustin Buendía-Eisman; L Castellote
Increased gene expression of Toll-like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis.
Esther J Pavón; Rubén Perandrés-López; Antonio Rosal-Vela; Joaquín Abián; José Luis Callejas Rubio; Montserrat Carrascal; Sonia García-Rodríguez; Antonio Lario; Victoria Longobardo; Norberto Ortego Centeno; Mercedes Zubiaur; Esther Zumaquero; Jaime Sancho
Increased expression and phosphorylation of the two S100A9 isoforms in mononuclear cells from patients with systemic lupus erythematosus: a proteomic signature for circulating low-density granulocytes.

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All Publications

2013: Esther J Pavón; Antonio Rosal-Vela; Mercedes Zubiaur; Esther Zumaquero; Joaquin Abian; José Luis Callejas Rubio; Montserrat Carrascal; Daniela Cerezo-Wallis; Sonia García-Rodríguez; Richard Graeff; Keng Meng Khoo; Fabio Malavasi; Norberto Ortego Centeno; Jaime Sancho
Increased CD38 expression in T cells and circulating anti-CD38 IgG autoantibodies differentially correlate with distinct cytokine profiles and disease activity in systemic lupus erythematosus patients.
Cytokine 2013;62(2):232-43.
2013: S Garcia-Rodriguez; P Navarro; J Orgaz-Molina; R Perandrés-López; J-C Ruiz; Jaime Sancho; E Zumaquero; S Arias-Santiago; Agustin Buendía-Eisman; L Castellote
Increased gene expression of Toll-like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis.
Journal of the European Academy of Dermatology and Venereology : JEADV 2013;27(2):242-50.
2012: Esther J Pavón; Rubén Perandrés-López; Antonio Rosal-Vela; Joaquín Abián; José Luis Callejas Rubio; Montserrat Carrascal; Sonia García-Rodríguez; Antonio Lario; Victoria Longobardo; Norberto Ortego Centeno; Mercedes Zubiaur; Esther Zumaquero; Jaime Sancho
Increased expression and phosphorylation of the two S100A9 isoforms in mononuclear cells from patients with systemic lupus erythematosus: a proteomic signature for circulating low-density granulocytes.
Journal of proteomics 2012;75(6):1778-91.
2012: Sonia Garcia-Rodriguez; Pilar Navarro; Norberto Ortego Centeno; Raquel Ríos-Fernandez; Jaime Sancho; Salvador Arias-Santiago; José Luis Callejas Rubio; Esther Zumaquero; Mercedes Zubiaur
Altered AKT1 and MAPK1 gene expression on peripheral blood mononuclear cells and correlation with T-helper-transcription factors in systemic lupus erythematosus patients.
Mediators of inflammation 2012;2012():495934.
2008: Pilar Muñoz; María Mittelbrunn; Hortensia de la Fuente; Manuel Pérez-Martínez; Angélica García-Pérez; Adriana Ariza-Veguillas; Fabio Malavasi; Mercedes Zubiaur; Francisco Sánchez-Madrid; Jaime Sancho
Antigen-induced clustering of surface CD38 and recruitment of intracellular CD38 to the immunologic synapse.
Blood 2008;111(7):3653-64.
2006: Fabio Malavasi; Silvia Deaglio; Enza Ferrero; Ada Funaro; Jaime Sancho; Clara Maria Ausiello; Erika Ortolan; Tiziana Vaisitti; Mercedes Zubiaur; Giorgio Fedele; Semra Aydin; Elena V Tibaldi; Ilaria Durelli; Riccardo Lusso; Franco Cozno; Alberto L Horenstein
CD38 and CD157 as receptors of the immune system: a bridge between innate and adaptive immunity.
Molecular medicine (Cambridge, Mass.) 2006;12(11-12):334-41.
2006: Esther Caparrós; Pilar Munoz; Elena Sierra-Filardi; Diego Serrano-Gómez; Amaya Puig-Kröger; José Luis Rodríguez-Fernández; Mario Mellado; Jaime Sancho; Mercedes Zubiaur; Angel L Corbí
DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production.
Blood 2006;107(10):3950-8.
2006: Esther J Pavón; Pilar Muñoz; Antonio Lario; Victoria Longobardo; Montserrat Carrascal; Joaquín Abián; Ana B Martin; Salvador A Arias; José Luis Callejas Rubio; Ricardo Sola; Francisco Navarro-Pelayo; Enrique Raya Alvarez; Norberto Ortego Centeno; Mercedes Zubiaur; Jaime Sancho
Proteomic analysis of plasma from patients with systemic lupus erythematosus: increased presence of haptoglobin alpha2 polypeptide chains over the alpha1 isoforms.
Proteomics 2006;6 Suppl 1():S282-92.
2006: Esther J Pavón; Pilar Muñoz; María-del-Carmen Navarro; Enrique Raya Alvarez; José Luis Callejas Rubio; Francisco Navarro-Pelayo; Norberto Ortego Centeno; Jaime Sancho; Mercedes Zubiaur
Increased association of CD38 with lipid rafts in T cells from patients with systemic lupus erythematosus and in activated normal T cells.
Molecular immunology 2006;43(7):1029-39.
2003: Pilar Muñoz; María-del-Carmen Navarro; Esther J Pavón; Javier Salmerón; Fabio Malavasi; Jaime Sancho; Mercedes Zubiaur
CD38 signaling in T cells is initiated within a subset of membrane rafts containing Lck and the CD3-zeta subunit of the T cell antigen receptor.
The Journal of biological chemistry 2003;278(50):50791-802.
2002: Silvia Deaglio; Mercedes Zubiaur; Armando Gregorini; Flavia Bottarel; Clara Maria Ausiello; Umberto Dianzani; Jaime Sancho; Fabio Malavasi
Human CD38 and CD16 are functionally dependent and physically associated in natural killer cells.
Blood 2002;99(7):2490-8.
2002: María Guirado; Isabel de Aós; Teresa Orta; Luis Rivas; Cox Terhorst; Mercedes Zubiaur; Jaime Sancho
Phosphorylation of the N-terminal and C-terminal CD3-epsilon-ITAM tyrosines is differentially regulated in T cells.
Biochemical and biophysical research communications 2002;291(3):574-81.
2002: Duncan Howie; Maria Simarro; Joan Sayos; María Guirado; Jaime Sancho; Cox Terhorst
Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation.
Blood 2002;99(3):957-65.
2002: Mercedes Zubiaur; Olga Fernández; Enza Ferrero; Javier Salmerón; Bernard Malissen; Fabio Malavasi; Jaime Sancho
CD38 is associated with lipid rafts and upon receptor stimulation leads to Akt/protein kinase B and Erk activation in the absence of the CD3-zeta immune receptor tyrosine-based activation motifs.
The Journal of biological chemistry 2002;277(1):13-22.
2001: Roberto Mallone; Ada Funaro; Mercedes Zubiaur; Germano Baj; Clara Maria Ausiello; Carlo Tacchetti; Jaime Sancho; Carlo E Grossi; Fabio Malavasi
Signaling through CD38 induces NK cell activation.
International immunology 2001;13(4):397-409.
1999: Mercedes Zubiaur; María Guirado; Cox Terhorst; Fabio Malavasi; Jaime Sancho
The CD3-gamma delta epsilon transducing module mediates CD38-induced protein-tyrosine kinase and mitogen-activated protein kinase activation in Jurkat T cells.
The Journal of biological chemistry 1999;274(29):20633-42.
1998: Massimo Morra; Mercedes Zubiaur; Cox Terhorst; Jaime Sancho; Fabio Malavasi
CD38 is functionally dependent on the TCR/CD3 complex in human T cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(7):581-92.
1997: I de Aós; M H Metzger; M Exley; C E Dahl; S Misra; Dexian Zheng; L Varticovski; Cox Terhorst; Jaime Sancho
Tyrosine phosphorylation of the CD3-epsilon subunit of the T cell antigen receptor mediates enhanced association with phosphatidylinositol 3-kinase in Jurkat T cells.
The Journal of biological chemistry 1997;272(40):25310-8.
1997: Mercedes Zubiaur; M Izquierdo; Cox Terhorst; Fabio Malavasi; Jaime Sancho
CD38 ligation results in activation of the Raf-1/mitogen-activated protein kinase and the CD3-zeta/zeta-associated protein-70 signaling pathways in Jurkat T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):193-205.
1997: C López-Rodríguez; Mercedes Zubiaur; Jaime Sancho; A Concha; Angel L Corbi
An octamer element functions as a regulatory element in the differentiation-responsive CD11c integrin gene promoter: OCT-2 inducibility during myelomonocytic differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5833-40.
1995: Baoping Wang; C Levelt; M Salio; D Zheng; Jaime Sancho; C P Liu; J She; M Huang; K Higgins; M J Sunshine
Over-expression of CD3 epsilon transgenes blocks T lymphocyte development.
International immunology 1995;7(3):435-48.
1994: R Franco; M E Peter; M S Choi; B Malissen; Jaime Sancho; Cox Terhorst
Characterization of the GTP/GDP binding site in the murine CD3-zeta polypeptide chain.
Immunology letters 1994;43(3):167-75.
1994: Mark A Exley; L Varticovski; M Peter; Jaime Sancho; Cox Terhorst
Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation.
The Journal of biological chemistry 1994;269(21):15140-6.
1993: C P Liu; R Ueda; J She; Jaime Sancho; Baoping Wang; G Weddell; Jeanne F Loring; C Kurahara; E C Dudley; Adrian C Hayday
Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.
The EMBO journal 1993;12(12):4863-75.
1993: I J Molina; Jaime Sancho; Cox Terhorst; Fred S Rosen; Eileen Remold-O'Donnell
T cells of patients with the Wiskott-Aldrich syndrome have a restricted defect in proliferative responses.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(8):4383-90.
1993: C G Hall; Jaime Sancho; Cox Terhorst
Reconstitution of T cell receptor zeta-mediated calcium mobilization in nonlymphoid cells.
Science (New York, N.Y.) 1993;261(5123):915-8.
1993: Jaime Sancho; R Franco; Talal A Chatila; C Hall; Cox Terhorst
The T cell receptor associated CD3-epsilon protein is phosphorylated upon T cell activation in the two tyrosine residues of a conserved signal transduction motif.
European journal of immunology 1993;23(7):1636-42.
1993: Jaime Sancho; M E Peter; R Franco; S Danielian; J S Kang; Remi Fagard; J Woods; J C Reed; M Kamoun; Cox Terhorst
Coupling of GTP-binding to the T cell receptor (TCR) zeta-chain with TCR-mediated signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(8 Pt 1):3230-42.
1993: Cox Terhorst; Mark A Exley; R Franco; C Hall; J Kang; B Mueller; Jaime Sancho; J She; T Wileman
Coupling of T-cell activation with T-cell receptor assembly.
The Year in immunology 1993;7():1-24.
1992: Jaime Sancho; Jeffrey A Ledbetter; M S Choi; Steven B Kanner; J P Deans; Cox Terhorst
CD3-zeta surface expression is required for CD4-p56lck-mediated upregulation of T cell antigen receptor-CD3 signaling in T cells.
The Journal of biological chemistry 1992;267(11):7871-9.
1992: M E Peter; C Hall; A Rühlmann; Jaime Sancho; Cox Terhorst
The T-cell receptor zeta chain contains a GTP/GDP binding site.
The EMBO journal 1992;11(3):933-41.
1992: Jaime Sancho; L B Silverman; E Castigli; D Ahern; A P Laudano; Cox Terhorst; Raif S Geha; Talal A Chatila
Developmental regulation of transmembrane signaling via the T cell antigen receptor/CD3 complex in human T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(5):1315-21.
1991: C Hall; Ben Berkhout; B Alarcon; Jaime Sancho; T Wileman; Cox Terhorst
Requirements for cell surface expression of the human TCR/CD3 complex in non-T cells.
International immunology 1991;3(4):359-68.
1991: Richard S Blumberg; Jaime Sancho; Steven C Ley; F V McDermott; K N Tan; J Breitmeyer; Cox Terhorst
Genetic reconstitution of the T cell receptor (TcR) alpha/beta heterodimer restores the association of CD3 zeta 2 with the TcR/CD3 complex.
European journal of immunology 1991;21(2):473-81.
1990: Richard S Blumberg; Steven C Ley; Jaime Sancho; N Lonberg; Elizabeth Lacy; F McDermott; V Schad; J L Greenstein; Cox Terhorst
Structure of the T-cell antigen receptor: evidence for two CD3 epsilon subunits in the T-cell receptor-CD3 complex.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(18):7220-4.
1990: Richard S Blumberg; B Alarcon; Jaime Sancho; F V McDermott; P Lopez; J Breitmeyer; Cox Terhorst
Assembly and function of the T cell antigen receptor. Requirement of either the lysine or arginine residues in the transmembrane region of the alpha chain.
The Journal of biological chemistry 1990;265(23):14036-43.
1990: R C Wong; Eileen Remold-O'Donnell; Donata Vercelli; Jaime Sancho; Cox Terhorst; Fred S Rosen; Raif S Geha; Talal A Chatila
Signal transduction via leukocyte antigen CD43 (sialophorin). Feedback regulation by protein kinase C.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(4):1455-60.
1989: Jaime Sancho; Talal A Chatila; R C Wong; C Hall; Richard S Blumberg; B Alarcon; Raif S Geha; Cox Terhorst
T-cell antigen receptor (TCR)-alpha/beta heterodimer formation is a prerequisite for association of CD3-zeta 2 into functionally competent TCR.CD3 complexes.
The Journal of biological chemistry 1989;264(34):20760-9.
1989: L B Silverman; R C Wong; Eileen Remold-O'Donnell; Donata Vercelli; Jaime Sancho; Cox Terhorst; Fred S Rosen; Raif S Geha; Talal A Chatila
Mechanism of mononuclear cell activation by an anti-CD43 (sialophorin) agonistic antibody.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(12):4194-200.