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David Sanders

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Natasha D Vetter; Hongyan Zheng; David A R Sanders; Karin E van Straaten; Shazia Anjum; Isaac Asiamah; Julie Boisvert-Martel; Rajendra C Jagdhane; Ed S Krol; David M Langill; Egiroh Omene; David R J Palmer
A Previously Unrecognized Kanosamine Biosynthesis Pathway in Bacillus subtilis.
Md Kausar Alam; Amira M El-Ganiny; Juxin Liu; David A R Sanders; Sharmin Afroz; Susan Kaminskyj
Aspergillus nidulans galactofuranose biosynthesis affects antifungal drug sensitivity.
Karin E van Straaten; Francoise H Routier; David A R Sanders
Towards the crystal structure elucidation of eukaryotic UDP-galactopyranose mutase.

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All Publications

2013: Natasha D Vetter; Hongyan Zheng; David A R Sanders; Karin E van Straaten; Shazia Anjum; Isaac Asiamah; Julie Boisvert-Martel; Rajendra C Jagdhane; Ed S Krol; David M Langill; Egiroh Omene; David R J Palmer
A Previously Unrecognized Kanosamine Biosynthesis Pathway in Bacillus subtilis.
Journal of the American Chemical Society 2013;135(16):5970-3.
2012: Md Kausar Alam; Amira M El-Ganiny; Juxin Liu; David A R Sanders; Sharmin Afroz; Susan Kaminskyj
Aspergillus nidulans galactofuranose biosynthesis affects antifungal drug sensitivity.
Fungal genetics and biology : FG & B 2012;49(12):1033-43.
2012: Karin E van Straaten; Francoise H Routier; David A R Sanders
Towards the crystal structure elucidation of eukaryotic UDP-galactopyranose mutase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 4):455-9.
2012: Karin E van Straaten; Françoise H Routier; David A R Sanders
Structural insight into the unique substrate binding mechanism and flavin redox state of UDP-galactopyranose mutase from Aspergillus fumigatus.
The Journal of biological chemistry 2012;287(14):10780-90.
2011: Sharmin Afroz; Amira M El-Ganiny; David A R Sanders; Susan Kaminskyj
Roles of the Aspergillus nidulans UDP-galactofuranose transporter, UgtA in hyphal morphogenesis, cell wall architecture, conidiation, and drug sensitivity.
Fungal genetics and biology : FG & B 2011;48(9):896-903.
2011: Sean A Dalrymple; Susan Kaminskyj; Inder Sheoran; David A R Sanders
Preliminary X-ray crystallographic studies of UDP-glucose-4-epimerase from Aspergillus nidulans.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 8):885-7.
2011: Josiah Obiero; David A R Sanders
Design of Deinococcus radiodurans thioredoxin reductase with altered thioredoxin specificity using computational alanine mutagenesis.
Protein science : a publication of the Protein Society 2011;20(6):1021-9.
2010: Karin E van Straaten; Hongyan Zheng; David R J Palmer; David A R Sanders
Structural investigation of myo-inositol dehydrogenase from Bacillus subtilis: implications for catalytic mechanism and inositol dehydrogenase subfamily classification.
The Biochemical journal 2010;432(2):237-47.
2010: Sarathy Karunan Partha; Ali Sadeghi-Khomami; Kathryn Slowski; Toshihisa Kotake; Neil R Thomas; David L Jakeman; David A R Sanders
Chemoenzymatic synthesis, inhibition studies, and X-ray crystallographic analysis of the phosphono analog of UDP-Galp as an inhibitor and mechanistic probe for UDP-galactopyranose mutase.
Journal of molecular biology 2010;403(4):578-90.
2010: Silvia Borrelli; Wesley F Zandberg; Sankar Mohan; Mary Ko; Fidel Martinez-Gutierrez; Sarathy Karunan Partha; David A R Sanders; Yossef Av-Gay; B Mario Pinto
Antimycobacterial activity of UDP-galactopyranose mutase inhibitors.
International journal of antimicrobial agents 2010;36(4):364-8.
2010: Carla Protsko; Claire Vieille; Maris Laivenieks; Lata Prasad; David A R Sanders; Louis T J Delbaere
Crystallization and preliminary X-ray diffraction analysis of the Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase I86A mutant.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 7):831-3.
2010: Amira M El-Ganiny; Inder Sheoran; David A R Sanders; Susan Kaminskyj
Aspergillus nidulans UDP-glucose-4-epimerase UgeA has multiple roles in wall architecture, hyphal morphogenesis, and asexual development.
Fungal genetics and biology : FG & B 2010;47(7):629-35.
2010: Maohai Fang; R Daniel Toogood; Andrea Macova; Karen Ho; Scott Franzblau; Michael R McNeil; David A R Sanders; David R J Palmer
Succinylphosphonate esters are competitive inhibitors of MenD that show active-site discrimination between homologous alpha-ketoglutarate-decarboxylating enzymes.
Biochemistry 2010;49(12):2672-9.
2010: Josiah Obiero; Vanessa Pittet; Sara A Bonderoff; David A R Sanders
Thioredoxin system from Deinococcus radiodurans.
Journal of bacteriology 2010;192(2):494-501.
2009: Sarathy Karunan Partha; Karin E van Straaten; David A R Sanders
Structural basis of substrate binding to UDP-galactopyranose mutase: crystal structures in the reduced and oxidized state complexed with UDP-galactopyranose and UDP.
Journal of molecular biology 2009;394(5):864-77.
2009: Karin E van Straaten; Claudio F Gonzalez; Ricardo B Valladares; Xiaohui Xu; Alexei V Savchenko; David A R Sanders
The structure of a putative S-formylglutathione hydrolase from Agrobacterium tumefaciens.
Protein science : a publication of the Protein Society 2009;18(10):2196-202.
2009: Sarathy Karunan Partha; Sara A Bonderoff; Karin E van Straaten; David A R Sanders
Expression, purification and preliminary X-ray crystallographic analysis of UDP-galactopyranose mutase from Deinococcus radiodurans.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 8):843-5.
2009: K E van Straaten; D M Langill; David R J Palmer; David A R Sanders
Purification, crystallization and preliminary X-ray analysis of NtdA, a putative pyridoxal phosphate-dependent aminotransferase from Bacillus subtilis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 4):426-9.
2009: Xiaohui Yao; Dustin W Bleile; Yue Yuan; Jay Chao; Karunan P Sarathy; David A R Sanders; B Mario Pinto; Melanie A O'Neill
Substrate directs enzyme dynamics by bridging distal sites: UDP-galactopyranose mutase.
Proteins 2009;74(4):972-9.
2008: Amira M El-Ganiny; David A R Sanders; Susan Kaminskyj
Aspergillus nidulans UDP-galactopyranose mutase, encoded by ugmA plays key roles in colony growth, hyphal morphogenesis, and conidiation.
Fungal genetics and biology : FG & B 2008;45(12):1533-42.
2008: Yi Yang; Amira M El-Ganiny; Geoffrey E Bray; David A R Sanders; Susan Kaminskyj
Aspergillus nidulans hypB encodes a Sec7-domain protein important for hyphal morphogenesis.
Fungal genetics and biology : FG & B 2008;45(5):749-59.
2008: Yue Yuan; Dustin W Bleile; Xin Wen; David A R Sanders; Kenji Itoh; Hung-wen Liu; B Mario Pinto
Investigation of binding of UDP-Galf and UDP-[3-F]Galf to UDP-galactopyranose mutase by STD-NMR spectroscopy, molecular dynamics, and CORCEMA-ST calculations.
Journal of the American Chemical Society 2008;130(10):3157-68.
2008: K E Van Straaten; A Hoffort; David R J Palmer; David A R Sanders
Purification, crystallization and preliminary X-ray analysis of inositol dehydrogenase (IDH) from Bacillus subtilis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 2):98-101.
2007: Richard Daniellou; Hongyan Zheng; David M Langill; David A R Sanders; David R J Palmer
Probing the promiscuous active site of myo-inositol dehydrogenase using synthetic substrates, homology modeling, and active site modification.
Biochemistry 2007;46(25):7469-77.
2007: Jennifer M Chad; Karunan Partha Sarathy; Todd D Gruber; Eshwari Addala; Laura L Kiessling; David A R Sanders
Site-directed mutagenesis of UDP-galactopyranose mutase reveals a critical role for the active-site, conserved arginine residues.
Biochemistry 2007;46(23):6723-32.
2007: Weihong Qiu; Lijuan Wang; Wenyun Lu; Amanda Boechler; David A R Sanders; Dongping Zhong
Dissection of complex protein dynamics in human thioredoxin.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(13):5366-71.
2007: Edyta A L Sieminska; Xiaohui Xu; Alexei Savchenko; David A R Sanders
The X-ray crystal structure of PA1607 from Pseudomonas aureginosa at 1.9 A resolution--a putative transcription factor.
Protein science : a publication of the Protein Society 2007;16(3):543-9.
2006: Josiah Obiero; Sara A Bonderoff; Meghan M Goertzen; David A R Sanders
Expression, purification, crystallization and preliminary X-ray crystallographic studies of Deinococcus radiodurans thioredoxin reductase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 8):757-60.
2006: Somenath Chowdhury; David A R Sanders; Gabriele Schatte; Heinz-Bernhard Kraatz
Discovery of a pseudo beta barrel: synthesis and formation by tiling of ferrocene cyclopeptides.
Angewandte Chemie (International ed. in English) 2006;45(5):751-4.
2005: Yue Yuan; Xin Wen; David A R Sanders; B Mario Pinto
Exploring the mechanism of binding of UDP-galactopyranose to UDP-galactopyranose mutase by STD-NMR spectroscopy and molecular modeling.
Biochemistry 2005;44(43):14080-9.
2005: David A R Sanders; John R Walker; Tatiana Skarina; Alexei Savchenko
The X-ray crystal structure of PA3566 from Pseudomonas aureginosa at 1.8 A resolution.
Proteins 2005;61(1):209-12.
2005: Konstantinos Beis; Velupillai Srikannathasan; Huanting Liu; Stephen W B Fullerton; Vicki A Bamford; David A R Sanders; Chris Whitfield; Mike R McNeil; James H Naismith
Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state.
Journal of molecular biology 2005;348(4):971-82.
2005: Edyta A L Sieminska; Andrea Macova; David R J Palmer; David A R Sanders
Crystallization and preliminary X-ray analysis of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) synthase (MenD) from Escherichia coli.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 5):489-92.
2004: Natacha Veerapen; Yue Yuan; David A R Sanders; B Mario Pinto
Synthesis of novel ammonium and selenonium ions and their evaluation as inhibitors of UDP-galactopyranose mutase.
Carbohydrate research 2004;339(13):2205-17.
2003: Heather Filson; Aine Fox; Dermot Kelleher; Henry J Windle; David A R Sanders
Purification, crystallization and preliminary X-ray analysis of an unusual thioredoxin from the gastric pathogen Helicobacter pylori.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 7):1280-2.
2003: Stephen W B Fullerton; Simon Daff; David A R Sanders; W John Ingledew; Chris Whitfield; Stephen K Chapman; James H Naismith
Potentiometric analysis of UDP-galactopyranose mutase: stabilization of the flavosemiquinone by substrate.
Biochemistry 2003;42(7):2104-9.
2001: David A R Sanders; AG Staines; Stephen McMahon; Mike R McNeil; Chris Whitfield; James H Naismith
UDP-galactopyranose mutase has a novel structure and mechanism.
Nature structural biology 2001;8(10):858-63.
2001: David A R Sanders; Stephen McMahon; G L Leonard; James H Naismith
Molecular placement of experimental electron density: a case study on UDP-galactopyranose mutase.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 10):1415-20.
2001: David A R Sanders; DN Moothoo; J Raftery; A J Howard; J R Helliwell; James H Naismith
The 1.2 A resolution structure of the Con A-dimannose complex.
Journal of molecular biology 2001;310(4):875-84.