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Niek Sanders

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Oliwia Andries; Stefaan C De Smedt; Jo Demeester; Luc Peelman; Marina De Filette; Mario Van Poucke; Niek N Sanders
Innate immune response and programmed cell death following carrier-mediated delivery of unmodified mRNA to respiratory cells.
Steven K Cool; Stefaan C De Smedt; Bart Geers; Ine Lentacker; Niek N Sanders
Enhancing nucleic acid delivery with ultrasound and microbubbles.
Sofie Denies; Niek N Sanders
Recent progress in canine tumor vaccination: potential applications for human tumor vaccines.

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2013: Oliwia Andries; Stefaan C De Smedt; Jo Demeester; Luc Peelman; Marina De Filette; Mario Van Poucke; Niek N Sanders
Innate immune response and programmed cell death following carrier-mediated delivery of unmodified mRNA to respiratory cells.
Journal of controlled release : official journal of the Controlled Release Society 2013;167(2):157-66.
2013: Steven K Cool; Stefaan C De Smedt; Bart Geers; Ine Lentacker; Niek N Sanders
Enhancing nucleic acid delivery with ultrasound and microbubbles.
Methods in molecular biology (Clifton, N.J.) 2013;948():195-204.
2012: Sofie Denies; Niek N Sanders
Recent progress in canine tumor vaccination: potential applications for human tumor vaccines.
Expert review of vaccines 2012;11(11):1375-86.
2012: Kevin Buyens; Xavier de Mollerat du Jeu; Stefaan C De Smedt; Joseph Demeester; Katarina Farkasova; Manfred Ogris; Liesbeth Peeters; Rupa Sawant; Vladimir Torchilin; Leo A van Grunsven; Kevin Braeckmans; Niek N Sanders
Liposome based systems for systemic siRNA delivery: stability in blood sets the requirements for optimal carrier design.
Journal of controlled release : official journal of the Controlled Release Society 2012;158(3):362-70.
2012: Marina De Filette; Mike Diamond; Sebastian Ulbert; Niek N Sanders
Recent progress in West Nile virus diagnosis and vaccination.
Veterinary research 2012;43(1):16.
2011: Bart Geers; Ine Lentacker; Stephen Meairs; Niek N Sanders; Angelika Alonso; Jo Demeester; Stefaan C De Smedt
Elucidating the mechanisms behind sonoporation with adeno-associated virus-loaded microbubbles.
Molecular pharmaceutics 2011;8(6):2244-51.
2011: Bart Geers; Ine Lentacker; Stephen Meairs; Niek N Sanders; Jo Demeester; Stefaan C De Smedt
Self-assembled liposome-loaded microbubbles: The missing link for safe and efficient ultrasound triggered drug-delivery.
Journal of controlled release : official journal of the Controlled Release Society 2011;152(2):249-56.
2011: Geertrui Tavernier; Oliwia Andries; Jo Demeester; Niek N Sanders; Stefaan C De Smedt; Joanna Rejman
mRNA as gene therapeutic: how to control protein expression.
Journal of controlled release : official journal of the Controlled Release Society 2011;150(3):238-47.
2010: Bart Geers; Ine Lentacker; Angelika Alonso; Stephen Meairs; Jo Demeester; Stefaan C De Smedt; Niek N Sanders
Adeno-associated virus loaded microbubbles as a tool for targeted gene delivery.
Journal of controlled release : official journal of the Controlled Release Society 2010;148(1):e59.
2010: Bart Geers; Ine Lentacker; Steven Cool; Jo Demeester; Stefaan C De Smedt; Niek N Sanders
Ultrasound responsive doxorubicin-loaded microbubbles; towards an easy applicable drug delivery platform.
Journal of controlled release : official journal of the Controlled Release Society 2010;148(1):e59-60.
2010: Ine Lentacker; Bart Geers; Jo Demeester; Stefaan C De Smedt; Niek N Sanders
Tumor cell killing efficiency of doxorubicin loaded microbubbles after ultrasound exposure.
Journal of controlled release : official journal of the Controlled Release Society 2010;148(1):e113-4.
2010: Kevin Braeckmans; Kevin Buyens; Broes Naeye; Dries Vercauteren; Hendrik Deschout; Koen Raemdonck; Katrien Remaut; Niek N Sanders; Jo Demeester; Stefaan C De Smedt
Advanced fluorescence microscopy methods illuminate the transfection pathway of nucleic acid nanoparticles.
Journal of controlled release : official journal of the Controlled Release Society 2010;148(1):69-74.
2010: Kevin Braeckmans; Kevin Buyens; Wim Bouquet; Chris Vervaet; Philippe Joye; Filip De Vos; Laurent Plawinski; Loïc Doeuvre; Eduardo Angles-Cano; Niek N Sanders; Jo Demeester; Stefaan C De Smedt
Sizing nanomatter in biological fluids by fluorescence single particle tracking.
Nano letters 2010;10(11):4435-42.
2010: Kristel Verminnen; Delphine Beeckman; Niek N Sanders; Stefaan De Smedt; Daisy Vanrompay
Vaccination of turkeys against Chlamydophila psittaci through optimised DNA formulation and administration.
Vaccine 2010;28(18):3095-105.
2010: Dries Vercauteren; Roosmarijn Vandenbroucke; Arwyn T Jones; Joanna Rejman; Jo Demeester; Stefaan C De Smedt; Niek N Sanders; Kevin Braeckmans
The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(3):561-9.
2010: Mathieu Vinken; Elke Decrock; Elke De Vuyst; Marijke De Bock; Roosmarijn E Vandenbroucke; Bruno G De Geest; Jo Demeester; Niek N Sanders; Tamara Vanhaecke; Luc Leybaert; Vera Rogiers
Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death.
Cellular and molecular life sciences : CMLS 2010;67(6):907-18.
2010: Kevin Buyens; Martin Meyer; Ernst Wagner; Jo Demeester; Stefaan C De Smedt; Niek N Sanders
Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy.
Journal of controlled release : official journal of the Controlled Release Society 2010;141(1):38-41.
2010: Ine Lentacker; Bart Geers; Jo Demeester; Stefaan C De Smedt; Niek N Sanders
Design and evaluation of doxorubicin-containing microbubbles for ultrasound-triggered doxorubicin delivery: cytotoxicity and mechanisms involved.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(1):101-8.
2009: Olivia Merkel; Damiano Librizzi; Andreas Pfestroff; Tino Schurrat; Kevin Buyens; Niek N Sanders; Stefaan C De Smedt; Martin Béhé; Thomas Kissel
Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging.
Journal of controlled release : official journal of the Controlled Release Society 2009;138(2):148-59.
2009: Kevin Buyens; Jo Demeester; Stefaan S De Smedt; Niek N Sanders
Elucidating the encapsulation of short interfering RNA in PEGylated cationic liposomes.
Langmuir : the ACS journal of surfaces and colloids 2009;25(9):4886-91.
2009: Ine Lentacker; Nan Wang; Roosmarijn Vandenbroucke; Jo Demeester; Stefaan C De Smedt; Niek N Sanders
Ultrasound exposure of lipoplex loaded microbubbles facilitates direct cytoplasmic entry of the lipoplexes.
Molecular pharmaceutics 2009;6(2):457-67.
2009: Niek N Sanders; Carsten Rudolph; Kevin Braeckmans; Stefaan C De Smedt; Jo Demeester
Extracellular barriers in respiratory gene therapy.
Advanced drug delivery reviews 2009;61(2):115-27.
2008: Ine Lentacker; Roosmarijn Vandenbroucke; Bart Lucas; Jo Demeester; Stefaan C De Smedt; Niek N Sanders
New strategies for nucleic acid delivery to conquer cellular and nuclear membranes.
Journal of controlled release : official journal of the Controlled Release Society 2008;132(3):279-88.
2008: Liesbeth Peeters; Ine Lentacker; Roosmarijn Vandenbroucke; Bart Lucas; Jo Demeester; Niek N Sanders; Stefaan C De Smedt
Can ultrasound solve the transport barrier of the neural retina?
Pharmaceutical research 2008;25(11):2657-65.
2008: Koen Raemdonck; Roosmarijn Vandenbroucke; Jo Demeester; Niek N Sanders; Stefaan C De Smedt
Maintaining the silence: reflections on long-term RNAi.
Drug discovery today 2008;13(21-22):917-31.
2008: Roosmarijn Vandenbroucke; Bruno G De Geest; Stefan Bonné; Mathieu Vinken; Tamara Van Haecke; Harry Heimberg; Ernst Wagner; Vera Rogiers; Stefaan C De Smedt; Jo Demeester; Niek N Sanders
Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters).
The journal of gene medicine 2008;10(7):783-94.
2008: Roosmarijn Vandenbroucke; Ine Lentacker; Jo Demeester; Stefaan C De Smedt; Niek N Sanders
Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles.
Journal of controlled release : official journal of the Controlled Release Society 2008;126(3):265-73.
2008: Kevin Buyens; Bart Lucas; Koen Raemdonck; Kevin Braeckmans; Jo Vercammen; Jelle Hendrix; Yves Engelborghs; Stefaan C De Smedt; Niek N Sanders
A fast and sensitive method for measuring the integrity of siRNA-carrier complexes in full human serum.
Journal of controlled release : official journal of the Controlled Release Society 2008;126(1):67-76.
2007: Niek N Sanders; Liesbeth Peeters; Ine Lentacker; Jo Demeester; Stefaan C De Smedt
Wanted and unwanted properties of surface PEGylated nucleic acid nanoparticles in ocular gene transfer.
Journal of controlled release : official journal of the Controlled Release Society 2007;122(3):226-35.
2007: Liesbeth Peeters; Niek N Sanders; A Jones; Jo Demeester; Stefaan C De Smedt
Post-pegylated lipoplexes are promising vehicles for gene delivery in RPE cells.
Journal of controlled release : official journal of the Controlled Release Society 2007;121(3):208-17.
2007: Niek N Sanders; Vincent G H Eijsink; Petra S van den Pangaart; R J Joost van Neerven; Peter J Simons; Stefaan C De Smedt; Jo Demeester
Mucolytic activity of bacterial and human chitinases.
Biochimica et biophysica acta 2007;1770(5):839-46.
2007: Bruno G De Geest; Niek N Sanders; Gleb B Sukhorukov; Jo Demeester; Stefaan C De Smedt
Release mechanisms for polyelectrolyte capsules.
Chemical Society reviews 2007;36(4):636-49.
2007: Marc Sutter; Sabrina Oliveira; Niek N Sanders; Bart Lucas; Arie van Hoek; Mark A Hink; Antonie J W G Visser; Stefaan C De Smedt; Wim E Hennink; Wim Jiskoot
Sensitive spectroscopic detection of large and denatured protein aggregates in solution by use of the fluorescent dye Nile red.
Journal of fluorescence 2007;17(2):181-92.
2007: Roosmarijn Vandenbroucke; Stefaan C De Smedt; Jo Demeester; Niek N Sanders
Cellular entry pathway and gene transfer capacity of TAT-modified lipoplexes.
Biochimica et biophysica acta 2007;1768(3):571-9.
2007: Liesbeth Peeters; Niek N Sanders; Jo Demeester; Stefaan C De Smedt
Challenges in non-viral ocular gene transfer.
Biochemical Society transactions 2007;35(Pt 1):47-9.
2007: Roosmarijn Vandenbroucke; Bart Lucas; Jo Demeester; Stefaan C De Smedt; Niek N Sanders
Nuclear accumulation of plasmid DNA can be enhanced by non-selective gating of the nuclear pore.
Nucleic acids research 2007;35(12):e86.
2006: Ine Lentacker; Stefaan C De Smedt; Jo Demeester; Niek N Sanders
Microbubbles which bind and protect DNA against nucleases.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e73-5.
2006: Niek N Sanders; Hilde Franckx; Kris De Boeck; J Haustraete; Stefaan C De Smedt; Jo Demeester
Role of magnesium in the failure of rhDNase therapy in patients with cystic fibrosis.
Thorax 2006;61(11):962-8.
2006: Katharina von Gersdorff; Niek N Sanders; Roosmarijn Vandenbroucke; Stefaan C De Smedt; Ernst Wagner; Manfred Ogris
The internalization route resulting in successful gene expression depends on both cell line and polyethylenimine polyplex type.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(5):745-53.
2006: Katrien Remaut; Niek N Sanders; Farzaneh Fayazpour; Jo Demeester; Stefaan C De Smedt
Influence of plasmid DNA topology on the transfection properties of DOTAP/DOPE lipoplexes.
Journal of controlled release : official journal of the Controlled Release Society 2006;115(3):335-43.
2006: Farzaneh Fayazpour; Bart Lucas; Carmen Alvarez-Lorenzo; Niek N Sanders; Jo Demeester; Stefaan C De Smedt
Physicochemical and transfection properties of cationic Hydroxyethylcellulose/DNA nanoparticles.
Biomacromolecules 2006;7(10):2856-62.
2006: Koen Raemdonck; Katrien Remaut; Bart Lucas; Niek N Sanders; Jo Demeester; Stefaan C De Smedt
In situ analysis of single-stranded and duplex siRNA integrity in living cells.
Biochemistry 2006;45(35):10614-23.
2006: Ine Lentacker; Bruno G De Geest; Roosmarijn Vandenbroucke; Liesbeth Peeters; Jo Demeester; Stefaan C De Smedt; Niek N Sanders
Ultrasound-responsive polymer-coated microbubbles that bind and protect DNA.
Langmuir : the ACS journal of surfaces and colloids 2006;22(17):7273-8.
2006: W L J Hinrichs; F A Manceñido; Niek N Sanders; Kevin Braeckmans; Stefaan C De Smedt; Jo Demeester; Henderik W Frijlink
The choice of a suitable oligosaccharide to prevent aggregation of PEGylated nanoparticles during freeze thawing and freeze drying.
International journal of pharmaceutics 2006;311(1-2):237-44.
2006: Katrien Remaut; Bart Lucas; Kevin Braeckmans; Niek N Sanders; Jo Demeester; Stefaan C De Smedt
Delivery of phosphodiester oligonucleotides: can DOTAP/DOPE liposomes do the trick?
Biochemistry 2006;45(6):1755-64.
2005: Katrien Remaut; Bart Lucas; Kevin Braeckmans; Niek N Sanders; Jo Demeester; Stefaan C De Smedt
Protection of oligonucleotides against nucleases by pegylated and non-pegylated liposomes as studied by fluorescence correlation spectroscopy.
Journal of controlled release : official journal of the Controlled Release Society 2005;110(1):212-26.
2005: Liesbeth Peeters; Niek N Sanders; Kevin Braeckmans; Koen Boussery; Johan Van de Voorde; Stefaan C De Smedt; Jo Demeester
Vitreous: a barrier to nonviral ocular gene therapy.
Investigative ophthalmology & visual science 2005;46(10):3553-61.
2005: Bart Lucas; Katrien Remaut; Niek N Sanders; Kevin Braeckmans; Stefaan C De Smedt; Jo Demeester
Studying the intracellular dissociation of polymer-oligonucleotide complexes by dual color fluorescence fluctuation spectroscopy and confocal imaging.
Biochemistry 2005;44(29):9905-12.
2005: W L J Hinrichs; Niek N Sanders; Stefaan C De Smedt; Jo Demeester; Henderik W Frijlink
Inulin is a promising cryo- and lyoprotectant for PEGylated lipoplexes.
Journal of controlled release : official journal of the Controlled Release Society 2005;103(2):465-79.
2005: Bart Lucas; Katrien Remaut; Niek N Sanders; Kevin Braeckmans; Stefaan C De Smedt; Jo Demeester
Towards a better understanding of the dissociation behavior of liposome-oligonucleotide complexes in the cytosol of cells.
Journal of controlled release : official journal of the Controlled Release Society 2005;103(2):435-50.
2005: Katrien Remaut; Bart Lucas; Kevin Braeckmans; Niek N Sanders; Stefaan C De Smedt; Jo Demeester
FRET-FCS as a tool to evaluate the stability of oligonucleotide drugs after intracellular delivery.
Journal of controlled release : official journal of the Controlled Release Society 2005;103(1):259-71.
2005: Katrien Remaut; Bart Lucas; Kevin Braeckmans; Niek N Sanders; Stefaan C De Smedt; Jo Demeester
Fluorescence energy transfer to study the degradation of double-labeled oligonucleotides.
Journal of controlled release : official journal of the Controlled Release Society 2005;101(1-3):352-4.
2005: Stefaan C De Smedt; Katrien Remaut; Bart Lucas; Kevin Braeckmans; Niek N Sanders; Jo Demeester
Studying biophysical barriers to DNA delivery by advanced light microscopy.
Advanced drug delivery reviews 2005;57(1):191-210.
2004: Bart Lucas; Elsa Van Rompaey; Katrien Remaut; Niek N Sanders; Stefaan C De Smedt; Jo Demeester
On the biological activity of anti-ICAM-1 oligonucleotides complexed to non-viral carriers.
Journal of controlled release : official journal of the Controlled Release Society 2004;96(1):207-19.
2003: Kevin Braeckmans; Liesbeth Peeters; Niek N Sanders; Stefaan C De Smedt; Jo Demeester
Three-dimensional fluorescence recovery after photobleaching with the confocal scanning laser microscope.
Biophysical journal 2003;85(4):2240-52.
2003: Niek N Sanders; Stefaan C De Smedt; Jo Demeester
Mobility and stability of gene complexes in biogels.
Journal of controlled release : official journal of the Controlled Release Society 2003;87(1-3):117-29.
2002: Niek N Sanders; Elsa Van Rompaey; Stefaan C De Smedt; Jo Demeester
On the transport of lipoplexes through cystic fibrosis sputum.
Pharmaceutical research 2002;19(4):451-6.
2002: Niek N Sanders; Stefaan C De Smedt; Seng Cheng; Jo Demeester
Pegylated GL67 lipoplexes retain their gene transfection activity after exposure to components of CF mucus.
Gene therapy 2002;9(6):363-71.
2001: Niek N Sanders; Elsa Van Rompaey; Stefaan C De Smedt; Jo Demeester
Structural alterations of gene complexes by cystic fibrosis sputum.
American journal of respiratory and critical care medicine 2001;164(3):486-93.
2001: Elsa Van Rompaey; Yves Engelborghs; Niek N Sanders; Stefaan C De Smedt; Jo Demeester
Interactions between oligonucleotides and cationic polymers investigated by fluorescence correlation spectroscopy.
Pharmaceutical research 2001;18(7):928-36.
2000: Niek N Sanders; Stefaan C De Smedt; Elsa Van Rompaey; P Simoens; Frans De Baets; Jo Demeester
Cystic fibrosis sputum: a barrier to the transport of nanospheres.
American journal of respiratory and critical care medicine 2000;162(5):1905-11.