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Stellan Sandler

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Tobias Rydgren; Andreas Börjesson; A Carlsson; Stellan Sandler
Elevated glucagon-like peptide-1 plasma levels, as a possible adaptive response, in diabetic NOD mice.
Andreas Börjesson; S G Rønn; A E Karlsen; N Billestrup; Stellan Sandler
β-cell specific overexpression of suppressor of cytokine signalling-3 does not protect against multiple low dose streptozotocin induced type 1 diabetes in mice.
Eva Ludvigsen; Eva Tiensuu Janson; Mats Stridsberg; Stellan Sandler
Altered expression of somatostatin receptors in pancreatic islets from NOD mice cultured at different glucose concentrations in vitro and in islets transplanted to diabetic NOD mice in vivo.

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All Publications

2012: Tobias Rydgren; Andreas Börjesson; A Carlsson; Stellan Sandler
Elevated glucagon-like peptide-1 plasma levels, as a possible adaptive response, in diabetic NOD mice.
Biochemical and biophysical research communications 2012;423(3):583-7.
2011: Andreas Börjesson; S G Rønn; A E Karlsen; N Billestrup; Stellan Sandler
β-cell specific overexpression of suppressor of cytokine signalling-3 does not protect against multiple low dose streptozotocin induced type 1 diabetes in mice.
Immunology letters 2011;136(1):74-9.
2011: Eva Ludvigsen; Eva Tiensuu Janson; Mats Stridsberg; Stellan Sandler
Altered expression of somatostatin receptors in pancreatic islets from NOD mice cultured at different glucose concentrations in vitro and in islets transplanted to diabetic NOD mice in vivo.
Experimental diabetes research 2011;2011():623472.
2010: Jan Sällström; Mattias Carlström; Johan Olerud; Bertil B Fredholm; Mattias Kouzmine; Stellan Sandler; A Erik G Persson
High-protein-induced glomerular hyperfiltration is independent of the tubuloglomerular feedback mechanism and nitric oxide synthases.
American journal of physiology. Regulatory, integrative and comparative physiology 2010;299(5):R1263-8.
2010: Martin Blixt; Bo Niklasson; Stellan Sandler
Pancreatic islets of bank vole show signs of dysfunction after prolonged exposure to high glucose concentrations in vitro.
The Journal of endocrinology 2010;206(1):47-54.
2009: Martin Blixt; Bo Niklasson; Stellan Sandler
Suppression of bank vole pancreatic islet function by proinflammatory cytokines.
Molecular and cellular endocrinology 2009;305(1-2):1-5.
2009: Tobias Rydgren; Stellan Sandler
The protective effect of simvastatin against low dose streptozotocin induced type 1 diabetes in mice is independent of inhibition of HMG-CoA reductase.
Biochemical and biophysical research communications 2009;379(4):1076-9.
2009: Johanna Henriksnäs; Christer Atuma; Mia Phillipson; Stellan Sandler; Lars Engstrand; Lena Holm
Acute effects of Helicobacter pylori extracts on gastric mucosal blood flow in the mouse.
World journal of gastroenterology : WJG 2009;15(2):219-25.
2008: Stellan Sandler; Annika K Andersson; Jenny Larsson; Natalia Makeeva; Therese Olsen; Per O G Arkhammar; John Bondo Hansen; F Anders Karlsson; Nils Welsh
Possible role of an ischemic preconditioning-like response mechanism in K(ATP) channel opener-mediated protection against streptozotocin-induced suppression of rat pancreatic islet function.
Biochemical pharmacology 2008;76(12):1748-56.
2008: Mia Phillipson; Malin E V Johansson; Johanna Henriksnäs; Joel Petersson; Sandra J Gendler; Stellan Sandler; A Erik G Persson; Gunnar Hansson; Lena Holm
The gastric mucus layers: constituents and regulation of accumulation.
American journal of physiology. Gastrointestinal and liver physiology 2008;295(4):G806-12.
2008: Lina Thorvaldson; S Stålhammar; Stellan Sandler
Effects of a diabetes-like environment in vitro on cytokine production by mouse splenocytes.
Cytokine 2008;43(1):93-7.
2008: Signe Hässler; Leena Peltonen; Stellan Sandler; Ola Winqvist
Aire deficiency causes increased susceptibility to streptozotocin-induced murine type 1 diabetes.
Scandinavian journal of immunology 2008;67(6):569-80.
2007: Martin Blixt; Bo Niklasson; Stellan Sandler
Characterization of beta-cell function of pancreatic islets isolated from bank voles developing glucose intolerance/diabetes: an animal model showing features of both type 1 and type 2 diabetes mellitus, and a possible role of the Ljungan virus.
General and comparative endocrinology 2007;154(1-3):41-7.
2007: Tobias Rydgren; Outi Vaarala; Stellan Sandler
Simvastatin protects against multiple low-dose streptozotocin-induced type 1 diabetes in CD-1 mice and recurrence of disease in nonobese diabetic mice.
The Journal of pharmacology and experimental therapeutics 2007;323(1):180-5.
2007: Arne Andersson; Ulf J Eriksson; Leif Jansson; Stellan Sandler; Michael Welsh; Nils Welsh
Claes Hellerström: a friendly islet explorer.
Diabetologia 2007;50(2):4 p following 496.
2007: Robert Hägerkvist; Stellan Sandler; Dariush Mokhtari; Nils Welsh
Amelioration of diabetes by imatinib mesylate (Gleevec): role of beta-cell NF-kappaB activation and anti-apoptotic preconditioning.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(2):618-28.
2007: Eva Ludvigsen; Mats Stridsberg; J E Taylor; M D Culler; Kjell Oberg; Eva Tiensuu Janson; Stellan Sandler
Regulation of insulin and glucagon secretion from rat pancreatic islets in vitro by somatostatin analogues.
Regulatory peptides 2007;138(1):1-9.
2006: Bo Niklasson; Annika Samsioe; M Blixt; Stellan Sandler; Ake Sjöholm; E Lagerquist; Ake Lernmark; William Klitz
Prenatal viral exposure followed by adult stress produces glucose intolerance in a mouse model.
Diabetologia 2006;49(9):2192-9.
2006: Tobias Rydgren; Daniel Bengtsson; Stellan Sandler
Complete protection against interleukin-1beta-induced functional suppression and cytokine-mediated cytotoxicity in rat pancreatic islets in vitro using an interleukin-1 cytokine trap.
Diabetes 2006;55(5):1407-12.
2006: Joey Lau; Andreas Börjesson; Maria Holstad; Stellan Sandler
Prolactin regulation of the expression of TNF-alpha, IFN-gamma and IL-10 by splenocytes in murine multiple low dose streptozotocin diabetes.
Immunology letters 2006;102(1):25-30.
2006: Andreas Börjesson; Annika K Andersson; Stellan Sandler
Survival of an islet allograft deficient in iNOS after implantation into diabetic NOD mice.
Cell transplantation 2006;15(8-9):769-75.
2005: Lina Thorvaldson; Sofia Johansson; Petter Höglund; Stellan Sandler
Impact of plastic adhesion in vitro on analysis of Th1 and Th2 cytokines and immune cell distribution from mice with multiple low-dose streptozotocin-induced diabetes.
Journal of immunological methods 2005;307(1-2):73-81.
2005: Joachim Størling; J Binzer; Annika K Andersson; R A Züllig; Morten Tonnesen; R Lehmann; Giatgen A Spinas; Stellan Sandler; Nils Billestrup; Thomas Mandrup-Poulsen
Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt.
Diabetologia 2005;48(10):2039-50.
2005: Eva Ludvigsen; Mats Stridsberg; Eva Tiensuu Janson; Stellan Sandler
Expression of somatostatin receptor subtypes 1-5 in pancreatic islets of normoglycaemic and diabetic NOD mice.
European journal of endocrinology / European Federation of Endocrine Societies 2005;153(3):445-54.
2005: Annika K Andersson; Andreas Börjesson; Johanna Sandgren; Stellan Sandler
Cytokines affect PDX-1 expression, insulin and proinsulin secretion from iNOS deficient murine islets.
Molecular and cellular endocrinology 2005;240(1-2):50-7.
2004: Annika K Andersson; Lina Thorvaldson; Carina Carlsson; Stellan Sandler
Cytokine-induced PGE(2) formation is reduced from iNOS deficient murine islets.
Molecular and cellular endocrinology 2004;220(1-2):21-9.
2004: Eva Ludvigsen; Richard Olsson; Mats Stridsberg; Eva Tiensuu Janson; Stellan Sandler
Expression and distribution of somatostatin receptor subtypes in the pancreatic islets of mice and rats.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(3):391-400.
2003: Lina Thorvaldson; Maria Holstad; Stellan Sandler
Cytokine release by murine spleen cells following multiple low dose streptozotocin-induced diabetes and treatment with a TNFalpha transcriptional inhibitor.
International immunopharmacology 2003;3(12):1609-17.
2003: Johan Wallström; Annika K Andersson; Stellan Sandler
Effects of interleukin-15 on suppression of rat pancreatic islets in vitro induced by proinflammatory cytokines.
Immunology letters 2003;88(2):141-5.
2003: Leif Jansson; Mikael Kullin; F Anders Karlsson; Birgitta Bodin; John Bondo Hansen; Stellan Sandler
K(ATP) channels and pancreatic islet blood flow in anesthetized rats: increased blood flow induced by potassium channel openers.
Diabetes 2003;52(8):2043-8.
2003: Aileen King; Arne Andersson; Berit L Strand; Joey Lau; Gudmund Skjåk-Braek; Stellan Sandler
The role of capsule composition and biologic responses in the function of transplanted microencapsulated islets of Langerhans.
Transplantation 2003;76(2):275-9.
2003: Mia Phillipson; Johanna Henriksnäs; Maria Holstad; Stellan Sandler; Lena Holm
Inducible nitric oxide synthase is involved in acid-induced gastric hyperemia in rats and mice.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(1):G154-62.
2003: Aileen King; Berit L Strand; Anne Mari Rokstad; Bård Kulseng; Arne Andersson; Gudmund Skjåk-Braek; Stellan Sandler
Improvement of the biocompatibility of alginate/poly-L-lysine/alginate microcapsules by the use of epimerized alginate as a coating.
Journal of biomedical materials research. Part A 2003;64(3):533-9.
2003: Annika M Svensson; Stellan Sandler; Leif Jansson
Role of superoxide anion in pancreatic islet blood flow regulation in anesthetized rats.
European journal of pharmacology 2003;459(1):59-64.
2003: Aileen King; Joey Lau; Astrid Nordin; Stellan Sandler; Arne Andersson
The effect of capsule composition in the reversal of hyperglycemia in diabetic mice transplanted with microencapsulated allogeneic islets.
Diabetes technology & therapeutics 2003;5(4):653-63.
2003: Johnny Sternesjö; Allan E Karlsen; Stellan Sandler
Involvement of the proteasome in IL-1beta induced suppression of islets of Langerhans in the rat.
Upsala journal of medical sciences 2003;108(1):37-50.
2003: Mikael Kullin; Z Li; J Bondo Hansen; Nils Welsh; F Anders Karlsson; Stellan Sandler
Protection of rat pancreatic islets by potassium channel openers against alloxan, sodium nitroprusside and interleukin-1beta mediated suppression--possible involvement of the mitochondrial membrane potential.
Diabetologia 2003;46(1):80-8.
2002: Tobias Rydgren; Stellan Sandler
Efficacy of 1400 W, a novel inhibitor of inducible nitric oxide synthase, in preventing interleukin-1beta-induced suppression of pancreatic islet function in vitro and multiple low-dose streptozotocin-induced diabetes in vivo.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(4):543-51.
2001: Aileen King; Stellan Sandler; Arne Andersson
The effect of host factors and capsule composition on the cellular overgrowth on implanted alginate capsules.
Journal of biomedical materials research 2001;57(3):374-83.
2001: E Karlsson; Stellan Sandler
Islet amyloid polypeptide promotes beta-cell proliferation in neonatal rat pancreatic islets.
Diabetologia 2001;44(8):1015-8.
2001: Maria Holstad; Stellan Sandler
A transcriptional inhibitor of TNF-alpha prevents diabetes induced by multiple low-dose streptozotocin injections in mice.
Journal of autoimmunity 2001;16(4):441-7.
2001: Annika K Andersson; Stellan Sandler
Melatonin protects against streptozotocin, but not interleukin-1beta-induced damage of rodent pancreatic beta-cells.
Journal of pineal research 2001;30(3):157-65.
2001: Annika K Andersson; M Flodström; Stellan Sandler
Cytokine-induced inhibition of insulin release from mouse pancreatic beta-cells deficient in inducible nitric oxide synthase.
Biochemical and biophysical research communications 2001;281(2):396-403.
2001: M Iwase; Stellan Sandler; Per-Ola Carlsson; Claes Hellerström; Leif Jansson
The pancreatic islets in spontaneously hypertensive rats: islet blood flow and insulin production.
European journal of endocrinology / European Federation of Endocrine Societies 2001;144(2):169-78.
2000: Per-Ola Carlsson; M Flodström; Stellan Sandler
Islet blood flow in multiple low dose streptozotocin-treated wild-type and inducible nitric oxide synthase-deficient mice.
Endocrinology 2000;141(8):2752-7.
2000: Aileen King; Arne Andersson; Stellan Sandler
Cytokine-induced functional suppression of microencapsulated rat pancreatic islets in vitro.
Transplantation 2000;70(2):380-3.
2000: Mikael Kullin; Z Li; John Bondo Hansen; Erik Björk; Stellan Sandler; F Anders Karlsson
K(ATP) channel openers protect rat islets against the toxic effect of streptozotocin.
Diabetes 2000;49(7):1131-6.
2000: D Liu; D Pavlovic; M C Chen; M Flodström; Stellan Sandler; Decio L Eizirik
Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).
Diabetes 2000;49(7):1116-22.
2000: Z Li; L Zhao; Stellan Sandler; F Anders Karlsson
Expression of pancreatic islet MHC class I, insulin, and ICA 512 tyrosine phosphatase in low-dose streptozotocin-induced diabetes in mice.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(6):761-7.
2000: Johan Saldeen; Stellan Sandler; Klaus Bendtzen; Nils Welsh
Liposome-mediated transfer of IL-1 receptor antagonist gene to dispersed islet cells does not prevent recurrence of disease in syngeneically transplanted NOD mice.
Cytokine 2000;12(4):405-8.
2000: Z Li; F Anders Karlsson; Stellan Sandler
Islet loss and alpha cell expansion in type 1 diabetes induced by multiple low-dose streptozotocin administration in mice.
The Journal of endocrinology 2000;165(1):93-9.
2000: E Karlsson; Mats Stridsberg; Stellan Sandler
Chromogranin-B regulation of IAPP and insulin secretion.
Regulatory peptides 2000;87(1-3):33-9.
2000: Per-Ola Carlsson; Arne Andersson; Carina Carlsson; Claes Hellerström; Erik Höglund; Aileen King; Orjan Källskog; Per Liss; Göran Mattsson; Richard Olsson; Fredrik Palm; Stellan Sandler; Björn Tyrberg; Leif Jansson
Engraftment and growth of transplanted pancreatic islets.
Upsala journal of medical sciences 2000;105(2):107-23.
2000: Stellan Sandler; Annika K Andersson; Andreea R Barbu; Claes Hellerström; Maria Holstad; Ella Karlsson; Jan-Olov Sandberg; E Strandell; Johan Saldeen; Johnny Sternesjö; Linda Tillmar; Decio L Eizirik; M Flodström; Nils Welsh
Novel experimental strategies to prevent the development of type 1 diabetes mellitus.
Upsala journal of medical sciences 2000;105(2):17-34.
1999: Maria Holstad; Stellan Sandler
Prolactin protects against diabetes induced by multiple low doses of streptozotocin in mice.
The Journal of endocrinology 1999;163(2):229-34.
1999: Jian-Man Lin; Johnny Sternesjö; Stellan Sandler; Peter Bergsten
Preserved pulsatile insulin release from prediabetic mouse islets.
Endocrinology 1999;140(9):3999-4004.
1999: M Flodström; Björn Tyrberg; Decio L Eizirik; Stellan Sandler
Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes.
Diabetes 1999;48(4):706-13.
1999: Michael Welsh; L Christmansson; T Karlsson; Stellan Sandler; Nils Welsh
Transgenic mice expressing Shb adaptor protein under the control of rat insulin promoter exhibit altered viability of pancreatic islet cells.
Molecular medicine (Cambridge, Mass.) 1999;5(3):169-80.
1999: Aileen King; Stellan Sandler; Arne Andersson; Claes Hellerström; Bård Kulseng; Gudmund Skjåk-Braek
Glucose metabolism in vitro of cultured and transplanted mouse pancreatic islets microencapsulated by means of a high-voltage electrostatic field.
Diabetes care 1999;22 Suppl 2():B121-6.
1999: Henrik Krook; J Wallström; Stellan Sandler
Function of rat pancreatic islets exposed to interleukin-18 in vitro.
Autoimmunity 1999;29(4):263-7.
1998: E Karlsson; Mats Stridsberg; Stellan Sandler
Leptin regulation of islet amyloid polypeptide secretion from mouse pancreatic islets.
Biochemical pharmacology 1998;56(10):1339-46.
1998: Per-Ola Carlsson; Stellan Sandler; Leif Jansson
Pancreatic islet blood perfusion in the nonobese diabetic mouse: diabetes-prone female mice exhibit a higher blood flow compared with male mice in the prediabetic phase.
Endocrinology 1998;139(8):3534-41.
1998: Johnny Sternesjö; Stellan Sandler
Effects of interleukin-12 in vitro on pancreatic islets isolated from normal rodents and from non-obese diabetic mice.
The Journal of endocrinology 1998;158(1):69-75.
1997: Maria Holstad; L Jansson; Stellan Sandler
Inhibition of nitric oxide formation by aminoguanidine: an attempt to prevent insulin-dependent diabetes mellitus.
General pharmacology 1997;29(5):697-700.
1997: Stellan Sandler; Arne Andersson; Decio L Eizirik; Claes Hellerström; Terje Espevik; Bård Kulseng; B Thu; Daniel G Pipeleers; Gudmund Skjåk-Braek
Assessment of insulin secretion in vitro from microencapsulated fetal porcine islet-like cell clusters and rat, mouse, and human pancreatic islets.
Transplantation 1997;63(12):1712-8.
1997: Johnny Sternesjö; Nils Welsh; Stellan Sandler
S-methyl-L-thiocitrulline counteracts interleukin 1 beta induced suppression of pancreatic islet function in vitro, but does not protect against multiple low-dose streptozotocin-induced diabetes in vivo.
Cytokine 1997;9(5):352-9.
1997: J O Sandberg; D L Eizirik; Stellan Sandler
IL-1 receptor antagonist inhibits recurrence of disease after syngeneic pancreatic islet transplantation to spontaneously diabetic non-obese diabetic (NOD) mice.
Clinical and experimental immunology 1997;108(2):314-7.
1997: E Strandell; Stellan Sandler
In vitro response to interleukin-1 beta and streptozotocin in pancreatic islets isolated from male and female nonobese diabetic mice.
The Journal of endocrinology 1997;153(1):81-6.
1997: C Oberg-Welsh; Stellan Sandler; A Andersson; Michael Welsh
Effects of vascular endothelial growth factor on pancreatic duct cell replication and the insulin production of fetal islet-like cell clusters in vitro.
Molecular and cellular endocrinology 1997;126(2):125-32.
1997: Johnny Sternesjö; Stellan Sandler
Interleukin-13 counteracts suppression induced by interleukin-1beta of glucose metabolism but not of insulin secretion in rat pancreatic islets.
Autoimmunity 1997;26(3):153-9.
1996: P O Carlsson; Stellan Sandler; Leif Jansson
Influence of the neurotoxin capsaicin on rat pancreatic islets in culture, and on the pancreatic islet blood flow of rats.
European journal of pharmacology 1996;312(1):75-81.
1996: Maria Holstad; L Jansson; Stellan Sandler
Effects of aminoguanidine on rat pancreatic islets in culture and on the pancreatic islet blood flow of anaesthetized rats.
Biochemical pharmacology 1996;51(12):1711-7.
1995: Decio L Eizirik; Stellan Sandler; Nils Welsh; L Juntti-Berggren; Per-Olof Berggren
Interleukin-1 beta-induced stimulation of insulin release in mouse pancreatic islets is related to diacylglycerol production and protein kinase C activation.
Molecular and cellular endocrinology 1995;111(2):159-65.
1995: S Reddy; N Salari-Lak; Stellan Sandler
Long-term effects of nicotinamide-induced inhibition of poly(adenosine diphosphate-ribose) polymerase activity in rat pancreatic islets exposed to interleukin-1 beta.
Endocrinology 1995;136(5):1907-12.
1995: Stellan Sandler; Johnny Sternesjö
Interleukin 4 impairs rat pancreatic islet function in vitro by an action different to that of interleukin 1.
Cytokine 1995;7(3):296-300.
1995: A M Svensson; Stellan Sandler; Leif Jansson
The blood flow in pancreatico-duodenal grafts in rats: inhibition of nitric oxide synthase preferentially decreases islet blood flow.
European journal of pharmacology 1995;275(1):99-103.
1995: Michael Welsh; Nils Welsh; K Bendtzen; J Mares; E Strandell; C Oberg; Stellan Sandler
Comparison of mRNA contents of interleukin-1 beta and nitric oxide synthase in pancreatic islets isolated from female and male nonobese diabetic mice.
Diabetologia 1995;38(2):153-60.
1995: S Reddy; Stellan Sandler
Age-dependent sensitivity to streptozotocin of pancreatic islets isolated from female NOD mice.
Autoimmunity 1995;22(2):121-6.
1995: Johnny Sternesjö; K Bendtzen; Stellan Sandler
Effects of prolonged exposure in vitro to interferon-gamma and tumour necrosis factor-alpha on nitric oxide and insulin production of rat pancreatic islets.
Autoimmunity 1995;20(3):185-90.
1994: Nils Welsh; B Margulis; Klaus Bendtzen; Stellan Sandler
Liposomal delivery of antioxidant enzymes protects against hydrogen peroxide- but not interleukin-1 beta-induced inhibition of glucose metabolism in rat pancreatic islets.
The Journal of endocrinology 1994;143(1):151-6.
1994: N Bigdeli; A Niemann; Stellan Sandler; Decio L Eizirik
Dissociation between interleukin-1 beta-induced expression of mRNA for superoxide dismutase and nitric oxide synthase in insulin-producing cells.
Biochemical and biophysical research communications 1994;203(3):1542-7.
1994: Stellan Sandler; Mats Stridsberg
Chronic exposure of cultured rat pancreatic islets to elevated concentrations of islet amyloid polypeptide (IAPP) causes a decrease in islet DNA content and medium insulin accumulation.
Regulatory peptides 1994;53(2):103-9.
1994: A M Svensson; C G Ostenson; Stellan Sandler; S Efendic; Leif Jansson
Inhibition of nitric oxide synthase by NG-nitro-L-arginine causes a preferential decrease in pancreatic islet blood flow in normal rats and spontaneously diabetic GK rats.
Endocrinology 1994;135(3):849-53.
1994: Jan-Olov Sandberg; A Andersson; Decio L Eizirik; Stellan Sandler
Interleukin-1 receptor antagonist prevents low dose streptozotocin induced diabetes in mice.
Biochemical and biophysical research communications 1994;202(1):543-8.
1994: Nils Welsh; Stellan Sandler
Protective action by hemin against interleukin-1 beta induced inhibition of rat pancreatic islet function.
Molecular and cellular endocrinology 1994;103(1-2):109-14.
1994: Stellan Sandler; Karsten Buschard; K Bendtzen
Effects of 1,25-dihydroxyvitamin D3 and the analogues MC903 and KH1060 on interleukin-1 beta-induced inhibition of rat pancreatic islet beta-cell function in vitro.
Immunology letters 1994;41(1):73-7.
1994: Decio L Eizirik; Stellan Sandler; Nils Welsh; M Cetkovic-Cvrlje; A Nieman; D A Geller; Daniel G Pipeleers; Klaus Bendtzen; Claes Hellerström
Cytokines suppress human islet function irrespective of their effects on nitric oxide generation.
The Journal of clinical investigation 1994;93(5):1968-74.
1994: Stellan Sandler; Jan-Olov Sandberg; A Andersson
RS-61443-induced glucose intolerance in mice.
Transplantation proceedings 1994;26(2):741-2.
1994: A M Svensson; Stellan Sandler; Leif Jansson
Pancreatic islet blood flow in the rat after administration of islet amyloid polypeptide or calcitonin gene-related peptide.
Diabetes 1994;43(3):454-8.
1994: Stellan Sandler; D L Eizirik; Johnny Sternesjö; Nils Welsh
Role of cytokines in regulation of pancreatic B-cell function.
Biochemical Society transactions 1994;22(1):26-30.
1994: Stellan Sandler
The biological role of islet amyloid polypeptide (amylin) in diabetes: some recent results.
Diabetologia 1994;37(2):225-6.
1994: Nils Welsh; Decio L Eizirik; Stellan Sandler
Nitric oxide and pancreatic beta-cell destruction in insulin dependent diabetes mellitus: don't take NO for an answer.
Autoimmunity 1994;18(4):285-90.
1994: Decio L Eizirik; Stellan Sandler; Nils Welsh; K Bendtzen; Claes Hellerström
Nicotinamide decreases nitric oxide production and partially protects human pancreatic islets against the suppressive effects of combinations of cytokines.
Autoimmunity 1994;19(3):193-8.
1993: Stellan Sandler; Claes Hellerström; D L Eizirk
Effects of nicotinamide supplementation on human pancreatic islet function in tissue culture.
The Journal of clinical endocrinology and metabolism 1993;77(6):1574-6.
1993: Jan-Olov Sandberg; Decio L Eizirik; Stellan Sandler; D E Tracey; A Andersson
Treatment with an interleukin-1 receptor antagonist protein prolongs mouse islet allograft survival.
Diabetes 1993;42(12):1845-51.
1993: Jan-Olov Sandberg; A Andersson; Stellan Sandler
Exposure of rat pancreatic islets to RS-61443 inhibits beta-cell function.
Transplantation 1993;56(5):1197-201.
1993: Decio L Eizirik; Stellan Sandler; J P Palmer
Repair of pancreatic beta-cells. A relevant phenomenon in early IDDM?
Diabetes 1993;42(10):1383-91.
1993: M Cetkovic-Cvrlje; Stellan Sandler; Decio L Eizirik
Nicotinamide and dexamethasone inhibit interleukin-1-induced nitric oxide production by RINm5F cells without decreasing messenger ribonucleic acid expression for nitric oxide synthase.
Endocrinology 1993;133(4):1739-43.
1993: Stellan Sandler; Nils Welsh
Interleukin-10 stimulates rat pancreatic islets in vitro, but fails to protect against interleukin-1.
Biochemical and biophysical research communications 1993;195(2):859-65.
1993: Mats Stridsberg; Stellan Sandler; Erik Wilander
Cosecretion of islet amyloid polypeptide (IAPP) and insulin from isolated rat pancreatic islets following stimulation or inhibition of beta-cell function.
Regulatory peptides 1993;45(3):363-70.
1993: C Svensson; Stellan Sandler; Claes Hellerström
Lack of long-term beta-cell glucotoxicity in vitro in pancreatic islets isolated from two mouse strains (C57BL/6J; C57BL/KsJ) with different sensitivities of the beta-cells to hyperglycaemia in vivo.
The Journal of endocrinology 1993;136(2):289-96.
1993: Olle Korsgren; A Andersson; Stellan Sandler
In vitro screening of putative compounds inducing fetal porcine pancreatic beta-cell differentiation: implications for cell transplantation in insulin-dependent diabetes mellitus.
Upsala journal of medical sciences 1993;98(1):39-52.
1993: Maria Holstad; Stellan Sandler
Aminoguanidine, an inhibitor of nitric oxide formation, fails to protect against insulitis and hyperglycemia induced by multiple low dose streptozotocin injections in mice.
Autoimmunity 1993;15(4):311-4.
1992: E Strandell; Stellan Sandler; C Boitard; Decio L Eizirik
Role of infiltrating T cells for impaired glucose metabolism in pancreatic islets isolated from non-obese diabetic mice.
Diabetologia 1992;35(10):924-31.
1992: Stellan Sandler; Leif Jansson; Nils Welsh
Adaptive response in beta-cell function in pancreatic islets isolated from partially pancreatectomized rats.
Molecular and cellular endocrinology 1992;86(3):149-56.
1992: Leif Jansson; Stellan Sandler
Alloxan, but not streptozotocin, increases blood perfusion of pancreatic islets in rats.
The American journal of physiology 1992;263(1 Pt 1):E57-63.
1992: Stellan Sandler; Leif Jansson; Olle Korsgren; A Andersson; Claes Hellerström
Engraftment of isolated islets after syngeneic transplantation into normal and diabetic mice.
Transplantation proceedings 1992;24(3):983-4.
1992: Leif Jansson; Stellan Sandler
The blood perfusion of transplanted pancreatic islets--evidence of a maturation of the blood-flow response to D-glucose with time after implantation.
Transplantation 1992;53(6):1368-9.
1992: Stellan Sandler; Decio L Eizirik; C Svensson; E Strandell; Michael Welsh; Nils Welsh
[Are cytokines mediators in the development of insulin-dependent diabetes mellitus?].
Läkartidningen 1992;89(20):1777-9.
1992: L A Håkan Borg; E Cagliero; Stellan Sandler; Nils Welsh; Decio L Eizirik
Interleukin-1 beta increases the activity of superoxide dismutase in rat pancreatic islets.
Endocrinology 1992;130(5):2851-7.
1992: Nils Welsh; Stellan Sandler
Interleukin-1 beta induces nitric oxide production and inhibits the activity of aconitase without decreasing glucose oxidation rates in isolated mouse pancreatic islets.
Biochemical and biophysical research communications 1992;182(1):333-40.
1992: Leif Jansson; Stellan Sandler
Dissociation between the blood flow response of transplanted pancreatic islets and that of the implantation organ.
Pancreas 1992;7(2):240-4.
1992: Decio L Eizirik; D E Tracey; K Bendtzen; Stellan Sandler
Role of receptor binding and gene transcription for both the stimulatory and inhibitory effects of interleukin-1 in pancreatic beta-cells.
Autoimmunity 1992;12(2):127-33.
1992: E Strandell; Stellan Sandler
Protection against hyperglycemia in female nonobese diabetic mice treated with 15-deoxyspergualin.
Autoimmunity 1992;14(2):159-65.
1991: Nils Welsh; Decio L Eizirik; K Bendtzen; Stellan Sandler
Interleukin-1 beta-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase.
Endocrinology 1991;129(6):3167-73.
1991: Decio L Eizirik; Stellan Sandler; G Ahnström; Michael Welsh
Exposure of pancreatic islets to different alkylating agents decreases mitochondrial DNA content but only streptozotocin induces long-lasting functional impairment of B-cells.
Biochemical pharmacology 1991;42(12):2275-82.
1991: B A Margulis; Stellan Sandler; Decio L Eizirik; Nils Welsh; Michael Welsh
Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 1 beta-induced impaired beta-cell function.
Diabetes 1991;40(11):1418-22.
1991: Leif Jansson; Stellan Sandler
Partial pancreatectomy in rats causes an impairment of the glucose-induced stimulation of pancreatic islet blood flow.
Experientia 1991;47(6):627-9.
1991: Decio L Eizirik; D E Tracey; K Bendtzen; Stellan Sandler
An interleukin-1 receptor antagonist protein protects insulin-producing beta cells against suppressive effects of interleukin-1 beta.
Diabetologia 1991;34(6):445-8.
1991: Leif Jansson; Stellan Sandler
The nitric oxide synthase II inhibitor NG-nitro-L-arginine stimulates pancreatic islet insulin release in vitro, but not in the perfused pancreas.
Endocrinology 1991;128(6):3081-5.
1991: Decio L Eizirik; K Bendtzen; Stellan Sandler
Short exposure of rat pancreatic islets to interleukin-1 beta induces a sustained but reversible impairment in beta-cell function: influence of protease activation, gene transcription, and protein synthesis.
Endocrinology 1991;128(3):1611-6.
1991: Nils Welsh; K Bendtzen; Stellan Sandler
Influence of protease on inhibitory and stimulatory effects of interleukin 1 beta on beta-cell function.
Diabetes 1991;40(2):290-4.
1991: Decio L Eizirik; E Strandell; Stellan Sandler
Prolonged exposure of pancreatic islets isolated from "pre-diabetic" non-obese diabetic mice to a high glucose concentration does not impair beta-cell function.
Diabetologia 1991;34(1):6-11.
1991: Stellan Sandler; Decio L Eizirik; C Svensson; E Strandell; Michael Welsh; Nils Welsh
Biochemical and molecular actions of interleukin-1 on pancreatic beta-cells.
Autoimmunity 1991;10(3):241-53.
1991: Nils Welsh; Michael Welsh; S Lindquist; Decio L Eizirik; K Bendtzen; Stellan Sandler
Interleukin-1 beta increases the biosynthesis of the heat shock protein hsp70 and selectively decreases the biosynthesis of five proteins in rat pancreatic islets.
Autoimmunity 1991;9(1):33-40.
1990: Olle Korsgren; Leif Jansson; Stellan Sandler; A Andersson
Hyperglycemia-induced B cell toxicity. The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background.
The Journal of clinical investigation 1990;86(6):2161-8.
1990: Stellan Sandler; K Bendtzen; Decio L Eizirik; E Strandell; Michael Welsh; Nils Welsh
Metabolism and beta-cell function of rat pancreatic islets exposed to human interleukin-1 beta in the presence of a high glucose concentration.
Immunology letters 1990;26(3):245-51.
1990: A Sjöholm; Nils Welsh; Stellan Sandler; Claes Hellerström
Role of polyamines in mitogenic and secretory responses of pancreatic beta-cells to growth factors.
The American journal of physiology 1990;259(5 Pt 1):C828-33.
1990: Decio L Eizirik; Michael Welsh; E Strandell; Nils Welsh; Stellan Sandler
Interleukin-1 beta depletes insulin messenger ribonucleic acid and increases the heat shock protein hsp70 in mouse pancreatic islets without impairing the glucose metabolism.
Endocrinology 1990;127(5):2290-7.
1990: Leif Jansson; Stellan Sandler
Altered blood flow regulation in autotransplanted pancreatic islets of rats.
The American journal of physiology 1990;259(1 Pt 1):E52-6.
1990: E Strandell; Decio L Eizirik; Stellan Sandler
Reversal of beta-cell suppression in vitro in pancreatic islets isolated from nonobese diabetic mice during the phase preceding insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1990;85(6):1944-50.
1990: Leif Jansson; Stellan Sandler
The blood perfusion of autotransplanted pancreatic islets in the rat.
Transplantation proceedings 1990;22(2):775-6.
1990: Stellan Sandler; K Bendtzen; Decio L Eizirik; Michael Welsh
Interleukin-6 affects insulin secretion and glucose metabolism of rat pancreatic islets in vitro.
Endocrinology 1990;126(2):1288-94.
1990: Leif Jansson; Olle Korsgren; Stellan Sandler; A Andersson
Influence of persistent hyperglycemia on transplanted pancreatic islets.
Hormone and metabolic research. Supplement series 1990;25():137-42.
1989: Decio L Eizirik; Stellan Sandler; Olle Korsgren; Leif Jansson; A Andersson
Persistent impairment of the insulin response to glucose both in vivo and in vitro after streptozotocin exposure: studies with grafted pancreatic islets and islets maintained in culture.
Acta endocrinologica 1989;121(6):849-56.
1989: Decio L Eizirik; Stellan Sandler
Human interleukin-1 beta induced stimulation of insulin release from rat pancreatic islets is accompanied by an increase in mitochondrial oxidative events.
Diabetologia 1989;32(11):769-73.
1989: Nils Welsh; T Nilsson; A Hallberg; P Arkhammar; Per-Olof Berggren; Stellan Sandler
Human interleukin 1 beta stimulates islet insulin release by a mechanism not dependent on changes in phospholipase C and protein kinase C activities or Ca2+ handling.
Acta endocrinologica 1989;121(5):698-704.
1989: Leif Jansson; Stellan Sandler
Pancreatic and islet blood flow in the regenerating pancreas after a partial pancreatectomy in adult rats.
Surgery 1989;106(5):861-6.
1989: Stellan Sandler; K Bendtzen; Decio L Eizirik; A Sjöholm; Nils Welsh
Decreased cell replication and polyamine content in insulin-producing cells after exposure to human interleukin 1 beta.
Immunology letters 1989;22(4):267-72.
1989: Decio L Eizirik; Stellan Sandler
Sustained exposure of toxically damaged mouse pancreatic islets to high glucose does not increase beta-cell dysfunction.
The Journal of endocrinology 1989;123(1):47-51.
1989: Decio L Eizirik; Stellan Sandler
Function and metabolism of pancreatic beta-cells maintained in culture following experimentally induced damage.
Pharmacology & toxicology 1989;65(3):163-8.
1989: Decio L Eizirik; Stellan Sandler; A Hallberg; K Bendtzen; A Sener; W J Malaisse
Differential sensitivity to beta-cell secretagogues in cultured rat pancreatic islets exposed to human interleukin-1 beta.
Endocrinology 1989;125(2):752-9.
1989: E Strandell; A Andersson; Carl G Groth; Stellan Sandler
Effects of (-)15-deoxyspergualin on pancreatic islet B-cell function in vitro and on the development of diabetes after multiple low dose streptozotocin administration.
Pharmacology & toxicology 1989;65(2):114-8.
1989: E Strandell; Decio L Eizirik; Stellan Sandler
Survival and B-cell function of mouse pancreatic islets maintained in culture after concomitant exposure to streptozotocin and nicotinamide.
Experimental and clinical endocrinology 1989;93(2-3):219-24.
1989: Stellan Sandler; K Bendtzen; L A Håkan Borg; Decio L Eizirik; E Strandell; Nils Welsh
Studies on the mechanisms causing inhibition of insulin secretion in rat pancreatic islets exposed to human interleukin-1 beta indicate a perturbation in the mitochondrial function.
Endocrinology 1989;124(3):1492-501.
1989: Leif Jansson; D L Eizirik; Stellan Sandler
Terbutaline decreases the blood flow of the pancreatic islets but does not reduce the diabetogenic action of streptozotocin in the rat.
European journal of pharmacology 1989;161(1):79-83.
1989: Olle Korsgren; Stellan Sandler; Leif Jansson; Carl G Groth; Claes Hellerström; A Andersson
Effects of culture conditions on formation and hormone content of fetal porcine isletlike cell clusters.
Diabetes 1989;38 Suppl 1():209-12.
1989: Stellan Sandler; I Swenne
Effects of streptozotocin exposure in vitro on the replication and repair of DNA in fetal rat pancreatic islet cells.
Pancreas 1989;4(1):53-8.
1989: Stellan Sandler; A Andersson; Olle Korsgren; J Tollemar; B Petersson; Carl G Groth; Claes Hellerström
Tissue culture of human fetal pancreas. Effects of nicotinamide on insulin production and formation of isletlike cell clusters.
Diabetes 1989;38 Suppl 1():168-71.
1989: Leif Jansson; Stellan Sandler
Influence of hyperglycemia on blood perfusion of autotransplanted pancreatic islets in diabetic rats.
Diabetes 1989;38 Suppl 1():196-8.
1988: Claes Hellerström; A Andersson; Carl G Groth; Stellan Sandler; Leif Jansson; Olle Korsgren; I Swenne; B Petersson; J Tollemar; G Tydén
Experimental pancreatic transplantation in diabetes.
Diabetes care 1988;11 Suppl 1():45-53.
1988: Decio L Eizirik; Stellan Sandler
Functional restoration of cultured mouse pancreatic islets after in vitro exposure to alloxan.
Pharmacology & toxicology 1988;63(5):396-9.
1988: E Strandell; Decio L Eizirik; Olle Korsgren; Stellan Sandler
Functional characteristics of cultured mouse pancreatic islets following exposure to different streptozotocin concentrations.
Molecular and cellular endocrinology 1988;59(1-2):83-91.
1988: Nils Welsh; A Hallberg; Stellan Sandler; Claes Hellerström
Use of liposomes to introduce substances into pancreatic islet cells.
Diabetes 1988;37(8):1123-8.
1988: Decio L Eizirik; Stellan Sandler; A Sener; W J Malaisse
Defective catabolism of D-glucose and L-glutamine in mouse pancreatic islets maintained in culture after streptozotocin exposure.
Endocrinology 1988;123(2):1001-7.
1988: Decio L Eizirik; E Strandell; K Bendtzen; Stellan Sandler
Functional characteristics of rat pancreatic islets maintained in culture after exposure to human interleukin 1.
Diabetes 1988;37(7):916-9.
1988: Stellan Sandler; A Andersson
Stimulation of cell replication in transplanted pancreatic islets by nicotinamide treatment.
Transplantation 1988;46(1):30-1.
1988: Decio L Eizirik; Stellan Sandler; Nils Welsh; Claes Hellerström
Preferential reduction of insulin production in mouse pancreatic islets maintained in culture after streptozotocin exposure.
Endocrinology 1988;122(4):1242-9.
1988: Olle Korsgren; Stellan Sandler; A S Landström; Leif Jansson; A Andersson
Large-scale production of fetal porcine pancreatic isletlike cell clusters. An experimental tool for studies of islet cell differentiation and xenotransplantation.
Transplantation 1988;45(3):509-14.
1988: Decio L Eizirik; E Strandell; Stellan Sandler
Culture of mouse pancreatic islets in different glucose concentrations modifies B cell sensitivity to streptozotocin.
Diabetologia 1988;31(3):168-74.
1987: Stellan Sandler; A Andersson; Olle Korsgren; J Tollemar; B Petersson; Carl G Groth; Claes Hellerström
Tissue culture of human fetal pancreas: growth hormone stimulates the formation and insulin production of islet-like cell clusters.
The Journal of clinical endocrinology and metabolism 1987;65(6):1154-8.
1987: Stellan Sandler; A Andersson; A S Landström; J Tollemar; H Borg; B Petersson; Carl G Groth; Claes Hellerström
Tissue culture of human fetal pancreas. Effects of human serum on development and endocrine function of isletlike cell clusters.
Diabetes 1987;36(12):1401-7.
1987: Decio L Eizirik; Stellan Sandler
The partial protective effect of branched chain amino acids against streptozotocin-induced cytotoxicity to mouse pancreatic islets in vitro.
Pharmacology & toxicology 1987;61(5):320-4.
1987: Stellan Sandler; A Andersson; Claes Hellerström
Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets.
Endocrinology 1987;121(4):1424-31.
1987: Stellan Sandler; B Nilsson; A Andersson
Cryopreservation of mouse pancreatic islets: effects of human serum on islet survival.
Upsala journal of medical sciences 1987;92(2):177-84.
1985: Stellan Sandler; A Andersson; A Schnell; A Mellgren; J Tollemar; H Borg; B Petersson; Carl G Groth; Claes Hellerström
Tissue culture of human fetal pancreas. Development and function of B-cells in vitro and transplantation of explants to nude mice.
Diabetes 1985;34(11):1113-9.
1984: A Andersson; H Borg; A Hallberg; C Hellerström; Stellan Sandler; A Schnell
Long-term effects of cyclosporin A on cultured mouse pancreatic islets.
Diabetologia 1984;27 Suppl():66-9.