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Michael Sanguinetti

Research Profile

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TOP 3
Vivek Garg; Anna Stary-Weinzinger; Michael C Sanguinetti
ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels.
Priyanka Garg; Michael C Sanguinetti
Structure-activity relationship of fenamates as Slo2.1 channel activators.
Vivek Garg; Frank B Sachse; Michael C Sanguinetti
Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule.

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All Publications

2013: Vivek Garg; Anna Stary-Weinzinger; Michael C Sanguinetti
ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels.
Molecular pharmacology 2013;83(4):805-13.
2012: Priyanka Garg; Michael C Sanguinetti
Structure-activity relationship of fenamates as Slo2.1 channel activators.
Molecular pharmacology 2012;82(5):795-802.
2012: Vivek Garg; Frank B Sachse; Michael C Sanguinetti
Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule.
The Journal of general physiology 2012;140(3):307-24.
2011: Vivek Garg; Frank B Sachse; Anna Stary-Weinzinger; Michael C Sanguinetti
Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide.
Molecular pharmacology 2011;80(4):630-7.
2010: Jennifer Abbruzzese; Frank B Sachse; Martin Tristani-Firouzi; Michael C Sanguinetti
Modification of hERG1 channel gating by Cd2+.
The Journal of general physiology 2010;136(2):203-24.
2010: Michael C Sanguinetti
HERG1 channelopathies.
Pflügers Archiv : European journal of physiology 2010;460(2):265-76.
2010: Li Dai; Vivek Garg; Michael C Sanguinetti
Activation of Slo2.1 channels by niflumic acid.
The Journal of general physiology 2010;135(3):275-95.
2009: Matthew Perry; Frank B Sachse; Jennifer Abbruzzese; Michael C Sanguinetti
PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(47):20075-80.
2009: Lan Cheng; Michael C Sanguinetti
Niflumic acid alters gating of HCN2 pacemaker channels by interaction with the outer region of S4 voltage sensing domains.
Molecular pharmacology 2009;75(5):1210-21.
2008: Guiscard Seebohm; Nathalie Strutz-Seebohm; Oana N Ureche; Ulrike Henrion; Ravshan Baltaev; Andreas F Mack; Ganna Korniychuk; Katja Steinke; Daniel Tapken; Arne Pfeufer; Stefan Kääb; Cecilia Bucci; Bernard Attali; Jean Merot; Jeremy M Tavare; Uta C Hoppe; Michael C Sanguinetti; Florian Lang
Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channels.
Circulation research 2008;103(12):1451-7.
2008: Niels Decher; Teresa Gonzalez; Anne Kathrin Streit; Frank B Sachse; Vijay Renigunta; Malle Soom; Stefan H Heinemann; Jürgen Daut; Michael C Sanguinetti
Structural determinants of Kvbeta1.3-induced channel inactivation: a hairpin modulated by PIP2.
The EMBO journal 2008;27(23):3164-74.
2008: Kaichiro Kamiya; Ryoko Niwa; Mikio Morishima; Haruo Honjo; Michael C Sanguinetti
Molecular determinants of hERG channel block by terfenadine and cisapride.
Journal of pharmacological sciences 2008;108(3):301-7.
2008: Lioara Restier; Lan Cheng; Michael C Sanguinetti
Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channels.
The Journal of physiology 2008;586(Pt 17):4179-91.
2008: David Fernandez; John Sargent; Frank B Sachse; Michael C Sanguinetti
Structural basis for ether-a-go-go-related gene K+ channel subtype-dependent activation by niflumic acid.
Molecular pharmacology 2008;73(4):1159-67.
2008: Matthew Perry; Michael C Sanguinetti
A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator.
Molecular pharmacology 2008;73(4):1044-51.
2008: David R Piper; Jason Rupp; Frank B Sachse; Michael C Sanguinetti; Martin Tristani-Firouzi
Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2008;21(1-3):37-46.
2007: Lan Cheng; Krista Kinard; Ramkumar Rajamani; Michael C Sanguinetti
Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels.
The Journal of pharmacology and experimental therapeutics 2007;322(3):931-9.
2007: Niels Decher; Vijay Renigunta; Marylou Zuzarte; Malle Soom; Stefan H Heinemann; Katherine W Timothy; Mark T Keating; Jürgen Daut; Michael C Sanguinetti; Igor Splawski
Impaired interaction between the slide helix and the C-terminus of Kir2.1: a novel mechanism of Andersen syndrome.
Cardiovascular research 2007;75(4):748-57.
2007: Matthew Perry; Frank B Sachse; Michael C Sanguinetti
Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(34):13827-32.
2007: Guiscard Seebohm; Nathalie Strutz-Seebohm; Ria Birkin; Ghislaine Dell; Cecilia Bucci; Maria R Spinosa; Ravshan Baltaev; Andreas F Mack; Ganna Korniychuk; Amit Choudhury; David Marks; Richard E Pagano; Bernard Attali; Arne Pfeufer; Robert Kass; Michael C Sanguinetti; Jeremy M Tavare; Florian Lang
Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels.
Circulation research 2007;100(5):686-92.
2007: Charles Antzelevitch; Guido D Pollevick; Jonathan M Cordeiro; Oscar Casis; Michael C Sanguinetti; Yoshiyasu Aizawa; Alejandra Guerchicoff; Ryan Pfeiffer; Antonio Oliva; Bernd Wollnik; Philip Gelber; Elias P Bonaros; Elena Burashnikov; Yuesheng Wu; John D Sargent; Stefan Schickel; Ralf Oberheiden; Atul Bhatia; Li-Fern Hsu; Michel Haïssaguerre; Rainer Schimpf; Martin Borggrefe; Christian Wolpert
Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death.
Circulation 2007;115(4):442-9.
2006: Niels Decher; Pradeep Kumar; Teresa Gonzalez; Bernard Pirard; Michael C Sanguinetti
Binding site of a novel Kv1.5 blocker: a "foot in the door" against atrial fibrillation.
Molecular pharmacology 2006;70(4):1204-11.
2006: Kaichiro Kamiya; Ryoko Niwa; John S Mitcheson; Michael C Sanguinetti
Molecular determinants of HERG channel block.
Molecular pharmacology 2006;69(5):1709-16.
2006: Michael C Sanguinetti; Martin Tristani-Firouzi
hERG potassium channels and cardiac arrhythmia.
Nature 2006;440(7083):463-9.
2006: Guiscard Seebohm; Nathalie Strutz-Seebohm; Oana Ureche; Ravshan Baltaev; Angelika Lampert; Ganna Kornichuk; Kaichiro Kamiya; Thomas V Wuttke; Holger Lerche; Michael C Sanguinetti; Florian Lang
Differential roles of S6 domain hinges in the gating of KCNQ potassium channels.
Biophysical journal 2006;90(6):2235-44.
2006: Oscar Casis; Søren-Peter Olesen; Michael C Sanguinetti
Mechanism of action of a novel human ether-a-go-go-related gene channel activator.
Molecular pharmacology 2006;69(2):658-65.
2005: Kui Hong; David R Piper; Aurora Diaz-Valdecantos; Josep Brugada; Antonio Oliva; Elena Burashnikov; José Santos De Soto; Josefina Grueso Montero; Ernesto Diaz-Enfante; Pedro Brugada; Frank Sachse; Michael C Sanguinetti; Ramon Brugada
De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in utero.
Cardiovascular research 2005;68(3):433-40.
2005: Niels Decher; Pradeep Kumar; Teresa Gonzalez; Vijay Renigunta; Michael C Sanguinetti
Structural basis for competition between drug binding and Kvbeta 1.3 accessory subunit-induced N-type inactivation of Kv1.5 channels.
Molecular pharmacology 2005;68(4):995-1005.
2005: David Fernandez; Azad Ghanta; Krista Kinard; Michael C Sanguinetti
Molecular mapping of a site for Cd2+-induced modification of human ether-à-go-go-related gene (hERG) channel activation.
The Journal of physiology 2005;567(Pt 3):737-55.
2005: Igor Splawski; Katherine W Timothy; Niels Decher; Pradeep Kumar; Frank B Sachse; Alan H Beggs; Michael C Sanguinetti; Mark T Keating
Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(23):8089-96; discussion 8086-8.
2005: Michael C Sanguinetti; John S Mitcheson
Predicting drug-hERG channel interactions that cause acquired long QT syndrome.
Trends in pharmacological sciences 2005;26(3):119-24.
2005: Guiscard Seebohm; Peter Westenskow; Florian Lang; Michael C Sanguinetti
Mutation of colocalized residues of the pore helix and transmembrane segments S5 and S6 disrupt deactivation and modify inactivation of KCNQ1 K+ channels.
The Journal of physiology 2005;563(Pt 2):359-68.
2005: David R Piper; William A Hinz; Chandra K Tallurri; Michael C Sanguinetti; Martin Tristani-Firouzi
Regional specificity of human ether-a'-go-go-related gene channel activation and inactivation gating.
The Journal of biological chemistry 2005;280(8):7206-17.
2005: Michael C Sanguinetti; Jun Chen; David Fernandez; Kaichiro Kamiya; John S Mitcheson; Jose A Sanchez-Chapula
Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs.
Novartis Foundation symposium 2005;266():159-66; discussion 166-70.
2005: John S Mitcheson; Matthew Perry; Phillip J Stansfeld; Michael C Sanguinetti; Harry Witchel; Jules Hancox
Structural determinants for high-affinity block of hERG potassium channels.
Novartis Foundation symposium 2005;266():136-50; discussion 150-8.
2005: David R Piper; Michael C Sanguinetti; Martin Tristani-Firouzi
Voltage sensor movement in the hERG K+ channel.
Novartis Foundation symposium 2005;266():46-52; discussion 52-6, 95-9.
2004: José A Sánchez-Chapula; Ricardo A Navarro-Polanco; Michael C Sanguinetti
Block of wild-type and inactivation-deficient human ether-a-go-go-related gene K+ channels by halofantrine.
Naunyn-Schmiedeberg's archives of pharmacology 2004;370(6):484-91.
2004: Igor Splawski; Katherine W Timothy; Leah M Sharpe; Niels Decher; Pradeep Kumar; Raffaella Bloise; Carlo Napolitano; Peter J Schwartz; Robert M Joseph; Karen Condouris; Helen Tager-Flusberg; silvia priori; Michael C Sanguinetti; Mark T Keating
Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism.
Cell 2004;119(1):19-31.
2004: Matthew Perry; Marcel J de Groot; Ray Helliwell; Derek Leishman; Martin Tristani-Firouzi; Michael C Sanguinetti; John S Mitcheson
Structural determinants of HERG channel block by clofilium and ibutilide.
Molecular pharmacology 2004;66(2):240-9.
2004: Niels Decher; Andreas S Barth; Teresa Gonzalez; Klaus Steinmeyer; Michael C Sanguinetti
Novel KChIP2 isoforms increase functional diversity of transient outward potassium currents.
The Journal of physiology 2004;557(Pt 3):761-72.
2004: Peter Westenskow; Igor Splawski; Katherine W Timothy; Mark T Keating; Michael C Sanguinetti
Compound mutations: a common cause of severe long-QT syndrome.
Circulation 2004;109(15):1834-41.
2004: Niels Decher; Jun Chen; Michael C Sanguinetti
Voltage-dependent gating of hyperpolarization-activated, cyclic nucleotide-gated pacemaker channels: molecular coupling between the S4-S5 and C-linkers.
The Journal of biological chemistry 2004;279(14):13859-65.
2004: David Fernandez; Azad Ghanta; Gregory W Kauffman; Michael C Sanguinetti
Physicochemical features of the HERG channel drug binding site.
The Journal of biological chemistry 2004;279(11):10120-7.
2004: Niels Decher; Bernard Pirard; Florian Bundis; Stefan Peukert; Karl-Heinz Baringhaus; Andreas E Busch; Klaus Steinmeyer; Michael C Sanguinetti
Molecular basis for Kv1.5 channel block: conservation of drug binding sites among voltage-gated K+ channels.
The Journal of biological chemistry 2004;279(1):394-400.
2003: Nanda A Singh; Peter Westenskow; Carole Charlier; Chris Pappas; Jonathan Leslie; Jessica Dillon; V Elving Anderson; Michael C Sanguinetti; Mark F Leppert
KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum.
Brain : a journal of neurology 2003;126(Pt 12):2726-37.
2003: Guiscard Seebohm; Michael Pusch; Jun Chen; Michael C Sanguinetti
Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels.
Circulation research 2003;93(10):941-7.
2003: Guiscard Seebohm; Michael C Sanguinetti; Michael Pusch
Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels.
The Journal of physiology 2003;552(Pt 2):369-78.
2003: Michael C Sanguinetti; Paul Bennett
Antiarrhythmic drug target choices and screening.
Circulation research 2003;93(6):491-9.
2003: David R Piper; Anthony Varghese; Michael C Sanguinetti; Martin Tristani-Firouzi
Gating currents associated with intramembrane charge displacement in HERG potassium channels.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(18):10534-9.
2003: Guiscard Seebohm; Jun Chen; Nathalie Strutz; Chris Culberson; Christian Lerche; Michael C Sanguinetti
Molecular determinants of KCNQ1 channel block by a benzodiazepine.
Molecular pharmacology 2003;64(1):70-7.
2003: Jose A Sănchez-Chapula; Tania Ferrer; Ricardo A Navarro-Polanco; Michael C Sanguinetti
Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain.
Molecular pharmacology 2003;63(5):1051-8.
2003: Martin Tristani-Firouzi; Michael C Sanguinetti
Structural determinants and biophysical properties of HERG and KCNQ1 channel gating.
Journal of molecular and cellular cardiology 2003;35(1):27-35.
2002: Jun Chen; Guiscard Seebohm; Michael C Sanguinetti
Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12461-6.
2002: José A Sánchez-Chapula; Ricardo A Navarro-Polanco; Chris Culberson; Jun Chen; Michael C Sanguinetti
Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block.
The Journal of biological chemistry 2002;277(26):23587-95.
2002: Martin Tristani-Firouzi; Jun Chen; Michael C Sanguinetti
Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels.
The Journal of biological chemistry 2002;277(21):18994-9000.
2002: Jun Chen; David R Piper; Michael C Sanguinetti
Voltage sensing and activation gating of HCN pacemaker channels.
Trends in cardiovascular medicine 2002;12(1):42-5.
2001: Jun Chen; John S Mitcheson; Martin Tristani-Firouzi; M Lin; Michael C Sanguinetti
The S4-S5 linker couples voltage sensing and activation of pacemaker channels.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11277-82.
2001: Fu-De Huang; Jun Chen; M Lin; Mark T Keating; Michael C Sanguinetti
Long-QT syndrome-associated missense mutations in the pore helix of the HERG potassium channel.
Circulation 2001;104(9):1071-5.
2001: Kaichiro Kamiya; John S Mitcheson; Kenji Yasui; Itsuo Kodama; Michael C Sanguinetti
Open channel block of HERG K(+) channels by vesnarinone.
Molecular pharmacology 2001;60(2):244-53.
2001: Kaichiro Kamiya; A Nishiyama; Kenji Yasui; M Hojo; Michael C Sanguinetti; Itsuo Kodama
Short- and long-term effects of amiodarone on the two components of cardiac delayed rectifier K(+) current.
Circulation 2001;103(9):1317-24.
2001: Mark T Keating; Michael C Sanguinetti
Molecular and cellular mechanisms of cardiac arrhythmias.
Cell 2001;104(4):569-80.
2001: Martin Tristani-Firouzi; Jun Chen; John S Mitcheson; Michael C Sanguinetti
Molecular biology of K(+) channels and their role in cardiac arrhythmias.
The American journal of medicine 2001;110(1):50-9.
2000: Jun Chen; John S Mitcheson; M Lin; Michael C Sanguinetti
Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel.
The Journal of biological chemistry 2000;275(46):36465-71.
2000: John S Mitcheson; Jun Chen; M Lin; Chris Culberson; Michael C Sanguinetti
A structural basis for drug-induced long QT syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12329-33.
2000: Jose A Sanchez-Chapula; Michael C Sanguinetti
Altered gating of HERG potassium channels by cobalt and lanthanum.
Pflügers Archiv : European journal of physiology 2000;440(2):264-74.
2000: Michael C Sanguinetti
Long QT syndrome: ionic basis and arrhythmia mechanism in long QT syndrome type 1.
Journal of cardiovascular electrophysiology 2000;11(6):710-2.
2000: Michael C Sanguinetti
Maximal function of minimal K+ channel subunits.
Trends in pharmacological sciences 2000;21(6):199-201.
2000: John S Mitcheson; Jun Chen; Michael C Sanguinetti
Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.
The Journal of general physiology 2000;115(3):229-40.
2000: J Zhang; Saïd Bendahhou; Michael C Sanguinetti; Louis J Ptácek
Functional consequences of chloride channel gene (CLCN1) mutations causing myotonia congenita.
Neurology 2000;54(4):937-42.
2000: J Zhang; Michael C Sanguinetti; Hubert Kwiecinski; Louis J Ptácek
Mechanism of inverted activation of ClC-1 channels caused by a novel myotonia congenita mutation.
The Journal of biological chemistry 2000;275(4):2999-3005.
1999: L Franqueza; M Lin; J Shen; Igor Splawski; Mark T Keating; Michael C Sanguinetti
Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits.
The Journal of biological chemistry 1999;274(30):21063-70.
1999: Z Wang; Martin Tristani-Firouzi; Q Xu; M Lin; Mark T Keating; Michael C Sanguinetti
Functional effects of mutations in KvLQT1 that cause long QT syndrome.
Journal of cardiovascular electrophysiology 1999;10(6):817-26.
1999: Michael C Sanguinetti
Dysfunction of delayed rectifier potassium channels in an inherited cardiac arrhythmia.
Annals of the New York Academy of Sciences 1999;868():406-13.
1999: Jun Chen; A Zou; Igor Splawski; Mark T Keating; Michael C Sanguinetti
Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation.
The Journal of biological chemistry 1999;274(15):10113-8.
1999: Michael C Sanguinetti; Q P Xu
Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes.
The Journal of physiology 1999;514 ( Pt 3)():667-75.
1999: John S Mitcheson; Michael C Sanguinetti
Biophysical properties and molecular basis of cardiac rapid and slow delayed rectifier potassium channels.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 1999;9(4-5):201-16.
1998: Zhi Su; A Zou; A Nonaka; I Zubair; Michael C Sanguinetti; William H Barry
Influence of prior Na+ pump activity on pump and Na+/Ca2+ exchange currents in mouse ventricular myocytes.
The American journal of physiology 1998;275(5 Pt 2):H1808-17.
1998: Martin Tristani-Firouzi; Michael C Sanguinetti
Voltage-dependent inactivation of the human K+ channel KvLQT1 is eliminated by association with minimal K+ channel (minK) subunits.
The Journal of physiology 1998;510 ( Pt 1)():37-45.
1998: A Zou; Q P Xu; Michael C Sanguinetti
A mutation in the pore region of HERG K+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation.
The Journal of physiology 1998;509 ( Pt 1)():129-37.
1997: Igor Splawski; Martin Tristani-Firouzi; Michael H Lehmann; Michael C Sanguinetti; Mark T Keating
Mutations in the hminK gene cause long QT syndrome and suppress IKs function.
Nature genetics 1997;17(3):338-40.
1997: Michael C Sanguinetti; P S Spector
Potassium channelopathies.
Neuropharmacology 1997;36(6):755-62.
1997: A Zou; Mark E Curran; Mark T Keating; Michael C Sanguinetti
Single HERG delayed rectifier K+ channels expressed in Xenopus oocytes.
The American journal of physiology 1997;272(3 Pt 2):H1309-14.
1997: Michael C Sanguinetti; A Zou
Molecular physiology of cardiac delayed rectifier K+ channels.
Heart and vessels 1997;Suppl 12():170-2.
1996: Michael C Sanguinetti; Mark E Curran; A Zou; J Shen; P S Spector; Donald L Atkinson; Mark T Keating
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel.
Nature 1996;384(6604):80-3.
1996: S J Compton; Robert L Lux; M R Ramsey; K R Strelich; Michael C Sanguinetti; LS Green; Mark T Keating; Jay W Mason
Genetically defined therapy of inherited long-QT syndrome. Correction of abnormal repolarization by potassium.
Circulation 1996;94(5):1018-22.
1996: Mark T Keating; Michael C Sanguinetti
Pathophysiology of ion channel mutations.
Current opinion in genetics & development 1996;6(3):326-33.
1996: Mark T Keating; Michael C Sanguinetti
Molecular genetic insights into cardiovascular disease.
Science (New York, N.Y.) 1996;272(5262):681-5.
1996: P S Spector; Mark E Curran; A Zou; Mark T Keating; Michael C Sanguinetti
Fast inactivation causes rectification of the IKr channel.
The Journal of general physiology 1996;107(5):611-9.
1996: Michael C Sanguinetti; Mark E Curran; P S Spector; Mark T Keating
Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(5):2208-12.
1996: P S Spector; Mark E Curran; Mark T Keating; Michael C Sanguinetti
Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides.
Circulation research 1996;78(3):499-503.
1995: H Konarzewska; G A Peeters; Michael C Sanguinetti
Repolarizing K+ currents in nonfailing human hearts. Similarities between right septal subendocardial and left subepicardial ventricular myocytes.
Circulation 1995;92(5):1179-87.
1995: Michael C Sanguinetti; C Jiang; Mark E Curran; Mark T Keating
A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel.
Cell 1995;81(2):299-307.
1995: G A Peeters; Michael C Sanguinetti; Y Eki; H Konarzewska; Dale G Renlund; Shreekanth V Karwande; William H Barry
Method for isolation of human ventricular myocytes from single endocardial and epicardial biopsies.
The American journal of physiology 1995;268(4 Pt 2):H1757-64.