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Owen Sansom

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Yafeng Ma; Owen J Sansom; Shigeko Yamashiro; William J Faller; Florencia Fiorito; David A F Gillespie; Ang Li; Silvana Libertini; Laura M Machesky
Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation.
S Radulescu; R A Ridgway; P Salgueiro; J Woodgett; Dimitris Athineos; N Barker; J Cordero; A Jung; J Neumann; K Oien; S Patel; R Poulsom; D M Pritchard; Owen J Sansom
Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation.
Thomas G Bird; Luke Boulter; Adriana Gambardella; Sabrina Gordon-Keylock; John P Iredale; Wei-Yu Lu; Rachel A Ridgway; Owen J Sansom; Jessica Taube; James A Thomas; Michael J Williams; Davina Wojtacha; Stuart J Forbes
Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling.

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2013: Yafeng Ma; Owen J Sansom; Shigeko Yamashiro; William J Faller; Florencia Fiorito; David A F Gillespie; Ang Li; Silvana Libertini; Laura M Machesky
Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation.
Development (Cambridge, England) 2013;140(10):2203-11.
2013: S Radulescu; R A Ridgway; P Salgueiro; J Woodgett; Dimitris Athineos; N Barker; J Cordero; A Jung; J Neumann; K Oien; S Patel; R Poulsom; D M Pritchard; Owen J Sansom
Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation.
Oncogene 2013;32(16):2048-57.
2013: Thomas G Bird; Luke Boulter; Adriana Gambardella; Sabrina Gordon-Keylock; John P Iredale; Wei-Yu Lu; Rachel A Ridgway; Owen J Sansom; Jessica Taube; James A Thomas; Michael J Williams; Davina Wojtacha; Stuart J Forbes
Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(16):6542-7.
2013: Jennifer P Morton; Owen J Sansom
MYC-y mice: from tumour initiation to therapeutic targeting of endogenous MYC.
Molecular oncology 2013;7(2):248-58.
2013: P A J Muller; P M Neilsen; Colin Nixon; J E Noll; J C Norman; Owen J Sansom; P Timpson; A G Trinidad; P V E van den Berghe; Patrick T Caswell; Cynthia R Coffill; S A Karim; David P Lane; Jennifer P Morton; S Zanivan; K H Vousden
Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion.
Oncogene 2013;32(10):1252-65.
2012: Rachel A Ridgway; Owen J Sansom; Bryan Serrels; Andrew Kinnaird; Susan Mason; Morwenna Muir; William J Muller; Hitesh Patel; Valerie G Brunton
Focal adhesion kinase is required for β-catenin-induced mobilization of epidermal stem cells.
Carcinogenesis 2012;33(12):2369-76.
2012: Laura M Machesky; Owen J Sansom
Rac1 in the driver's seat for melanoma.
Pigment cell & melanoma research 2012;25(6):762-4.
2012: Ang Li; Yafeng Ma; Karen Blyth; Meng Jin; Lionel Larue; Susan Mason; Richard L Mort; Owen J Sansom; Laura M Machesky
Activated mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism.
The Journal of investigative dermatology 2012;132(11):2610-21.
2012: Sorina Radulescu; Rachel A Ridgway; Pedro Salgueiro; Kurt Anderson; Matthew J Brookes; Samuel J Ford; Tariq H Iqbal; Ewan McGhee; Daniel H Stones; Chris Tselepis; Owen J Sansom
Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo.
Cell reports 2012;2(2):270-82.
2012: Imran Ahmad; Owen J Sansom; Hing Y Leung
Exploring molecular genetics of bladder cancer: lessons learned from mouse models.
Disease models & mechanisms 2012;5(3):323-32.
2012: L M Tho; S Libertini; R Rampling; Owen J Sansom; David A F Gillespie
Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis.
Oncogene 2012;31(11):1366-75.
2012: Daniel M Klotz; Karin Kroboth; Paul L Appleton; Scott A Nelson; Ian P Newton; Sorina Radulescu; Rachel A Ridgway; Owen J Sansom; Inke S Näthke
The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively.
Journal of cell science 2012;125(Pt 4):887-95.
2012: Marta A Dozynkiewicz; Charlie Gourley; Joan Grindlay; Nigel B Jamieson; Iain Macpherson; Colin J McKay; Jennifer P Morton; Colin Nixon; Owen J Sansom; David Strachan; Paul Timpson; Peter V E van den Berghe; Anne von Thun; Kurt Anderson; Ross Carter; Patrick T Caswell; Jim C Norman
Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression.
Developmental cell 2012;22(1):131-45.
2012: Nigel B Jamieson; Colin J McKay; Douglas C Morran; Jennifer P Morton; Asif Ali; Christopher R Carter; Euan J Dickson; T R Jeffry Evans; Owen J Sansom; Karin A Oien
MicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(2):534-45.
2011: Ang Li; Colin R Lindsay; Yafeng Ma; Jonathan Chernoff; Robert H Insall; Ian J Jackson; Lionel Larue; Richard L Mort; Owen J Sansom; Scott B Snapper; David Stevenson; Douglas Strathdee; Xinzi Yu; Laura M Machesky
Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression.
Developmental cell 2011;21(4):722-34.
2011: Imran Ahmad; Robert J Barnetson; Valerie G Brunton; Joanne Edwards; William J Muller; Colin Nixon; Rachana Patel; Owen J Sansom; Morag Seywright; Lukram Babloo Singh; Hing Y Leung
HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(39):16392-7.
2011: Imran Ahmad; Mona Foth; Hing Y Leung; Carol-Ann Morris; Owen J Sansom; Lukram Babloo Singh; Makoto Mark Taketo; Xue-Ru Wu; Tomoko Iwata
K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder.
Disease models & mechanisms 2011;4(4):548-55.
2011: Michael S Samuel; Owen J Sansom; Ewald Schröder; David Strachan; Paul Timpson; Valerie M Weaver; Jing Zhou; Kurt I Anderson; Nick Barker; Valerie G Brunton; Hans Clevers; Daniel R Croft; Jose I Lopez; Ewan J McGhee; June Munro; Michael F Olson
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.
Cancer cell 2011;19(6):776-91.
2011: Jennifer P Morton; Colin W Steele; Owen J Sansom
Timing is everything: Brca2 and p53 mutations in pancreatic cancer.
Gastroenterology 2011;140(4):1143-6.
2011: Daniel R Croft; Diane Crighton; Michael S Samuel; Filipe C Lourenco; June Munro; Jenifer Wood; Karim Bensaad; Karen H Vousden; Owen J Sansom; Kevin M Ryan; Michael F Olson
p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival.
Cell research 2011;21(4):666-82.
2011: I Ahmad; Jennifer P Morton; L B Singh; S M Radulescu; R A Ridgway; S Patel; J Woodgett; D J Winton; M M Taketo; X-R Wu; Hing Y Leung; Owen J Sansom
β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation.
Oncogene 2011;30(2):178-89.
2011: Kevin Myant; Owen J Sansom
Efficient Wnt mediated intestinal hyperproliferation requires the cyclin D2-CDK4/6 complex.
Cell division 2011;6(1):3.
2010: Alicia M Cole; Rachel A Ridgway; Sahra E Derkits; Lee Parry; Nick Barker; Hans Clevers; Alan R Clarke; Owen J Sansom
p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium.
EMBO molecular medicine 2010;2(11):472-86.
2010: Alicia M Cole; Kevin Myant; Karen R Reed; Rachel A Ridgway; Dimitris Athineos; Gijs R van den Brink; Vanesa Muncan; Hans Clevers; Alan R Clarke; Peter Sicinski; Owen J Sansom
Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss.
Cancer research 2010;70(20):8149-58.
2010: Brendan Doyle; Jennifer P Morton; David W Delaney; Rachel A Ridgway; Julie A Wilkins; Owen J Sansom
p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma.
The Journal of pathology 2010;222(2):129-37.
2010: Gabrielle H Ashton; Jennifer P Morton; Kevin Myant; Toby J Phesse; Rachel A Ridgway; Victoria Marsh; Julie A Wilkins; Dimitris Athineos; Vanesa Muncan; Richard Kemp; Kristi Neufeld; Hans Clevers; Valerie G Brunton; Douglas J Winton; Xiaoyan Wang; Rosalie C Pelz; Alan R Clarke; Margaret C Frame; Owen J Sansom
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.
Developmental cell 2010;19(2):259-69.
2010: Jennifer P Morton; Nigel B Jamieson; Saadia A Karim; Dimitris Athineos; Rachel A Ridgway; Colin Nixon; Colin J McKay; Ross Carter; Valerie G Brunton; Margaret C Frame; Alan Ashworth; Karin A Oien; T R Jeffry Evans; Owen J Sansom
LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest.
Gastroenterology 2010;139(2):586-97, 597.e1-6.
2010: Imran Ahmad; Owen J Sansom
Today's research: tomorrow's therapies.
Future oncology (London, England) 2010;6(7):1095-7.
2010: Jennifer P Morton; Saadia A Karim; Kathryn Graham; Paul Timpson; Nigel Jamieson; Dimitris Athineos; Brendan Doyle; Colin McKay; Man-Yeung Heung; Karin A Oien; Margaret C Frame; T R Jeffry Evans; Owen J Sansom; Valerie G Brunton
Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma.
Gastroenterology 2010;139(1):292-303.
2010: D Athineos; Owen J Sansom
Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine.
Oncogene 2010;29(17):2585-90.
2010: Aaron J Quyn; Paul L Appleton; Francis A Carey; Robert J C Steele; Nick Barker; Hans Clevers; Rachel A Ridgway; Owen J Sansom; Inke S Näthke
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.
Cell stem cell 2010;6(2):175-81.
2010: Jennifer P Morton; Paul Timpson; Saadia A Karim; Rachel A Ridgway; Dimitris Athineos; Brendan Doyle; Nigel B Jamieson; Karin A Oien; Andrew M Lowy; Valerie G Brunton; Margaret C Frame; T R Jeffry Evans; Owen J Sansom
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(1):246-51.
2009: Julia Cordero; Marcos Vidal; Owen J Sansom
APC as a master regulator of intestinal homeostasis and transformation: from flies to vertebrates.
Cell cycle (Georgetown, Tex.) 2009;8(18):2926-31.
2009: Imran Ahmad; Owen J Sansom; Hing Y Leung
The role of murine models of prostate cancer in drug target discovery and validation.
Expert opinion on drug discovery 2009;4(8):879-88.
2009: Bryan Serrels; Alan Serrels; Susan M Mason; Christine Baldeschi; Gabrielle H Ashton; M Canel; Lorna J Mackintosh; Brendan Doyle; Tim P Green; Margaret C Frame; Owen J Sansom; Valerie G Brunton
A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model.
Carcinogenesis 2009;30(2):249-57.
2009: Nick Barker; Rachel A Ridgway; Johan H van Es; Marc van de Wetering; Harry Begthel; Maaike van den Born; Esther Danenberg; Alan R Clarke; Owen J Sansom; Hans Clevers
Crypt stem cells as the cells-of-origin of intestinal cancer.
Nature 2009;457(7229):608-11.
2009: Craig Stevens; Yao Lin; Ben Harrison; Lindsay Burch; Rachel A Ridgway; Owen J Sansom; Ted R Hupp
Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling.
The Journal of biological chemistry 2009;284(1):334-44.
2009: Boris Y Shorning; Joanna Zabkiewicz; Afshan McCarthy; Helen B Pearson; Douglas J Winton; Owen J Sansom; Alan Ashworth; Alan R Clarke
Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine.
PloS one 2009;4(1):e4264.
2008: Karen R Reed; Dimitris Athineos; Valerie S Meniel; Julie A Wilkins; Rachel A Ridgway; Zoé D Burke; Vanesa Muncan; Alan R Clarke; Owen J Sansom
B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(48):18919-23.
2008: Victoria Marsh; Douglas J Winton; Geraint T Williams; Nicole Dubois; Andreas Trumpp; Owen J Sansom; Alan R Clarke
Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation.
Nature genetics 2008;40(12):1436-44.
2008: Toby J Phesse; Lee Parry; Karen R Reed; Kenneth B Ewan; Trevor C Dale; Owen J Sansom; Alan R Clarke
Deficiency of Mbd2 attenuates Wnt signaling.
Molecular and cellular biology 2008;28(19):6094-103.
2008: Julie A Wilkins; Owen J Sansom
C-Myc is a critical mediator of the phenotypes of Apc loss in the intestine.
Cancer research 2008;68(13):4963-6.
2008: Charles E Patek; Mark J Arends; William A H Wallace; Feijun Luo; Suzanne Hagan; David G Brownstein; Lorraine Rose; Paul S Devenney; Marion Walker; Sarah J Plowman; Rachel L Berry; Walter Kolch; Owen J Sansom; David J Harrison; Martin L Hooper
Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis.
Experimental cell research 2008;314(5):1105-14.
2008: Charles E Patek; Mark J Arends; Lorraine Rose; Feijun Luo; Marion Walker; Paul S Devenney; Rachel L Berry; Nicola J Lawrence; Rachel A Ridgway; Owen J Sansom; Martin L Hooper
The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine.
BMC gastroenterology 2008;8():24.
2008: Imran Ahmad; Owen J Sansom; Hing Y Leung
Advances in mouse models of prostate cancer.
Expert reviews in molecular medicine 2008;10():e16.
2008: Karen R Reed; Valerie Meniel; Victoria Marsh; Alicia Cole; Owen J Sansom; Alan R Clarke
A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine.
BMC cancer 2008;8():162.
2007: Owen J Sansom; Fiona C Mansergh; Martin J Evans; Julie A Wilkins; Alan R Clarke
Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice.
Gut 2007;56(10):1410-4.
2007: Alan R Clarke; N Jones; F Pryde; Y Adachi; Owen J Sansom
53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy.
Oncogene 2007;26(43):6349-55.
2007: Jennifer Berger; Owen J Sansom; Alan Clarke; Adrian Bird
MBD2 is required for correct spatial gene expression in the gut.
Molecular and cellular biology 2007;27(11):4049-57.
2007: Owen J Sansom; Kathryn Maddison; Alan R Clarke
Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer.
Nature clinical practice. Oncology 2007;4(5):305-15.
2007: Lesley Stark; Kirsten Reid; Owen J Sansom; Farhat V Din; Sylvie M Guichard; Iain Mayer; Duncan I Jodrell; Alan R Clarke; Malcolm G Dunlop
Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer.
Carcinogenesis 2007;28(5):968-76.
2007: Owen J Sansom; Valerie Meniel; Vanesa Muncan; Toby J Phesse; Julie A Wilkins; Karen R Reed; J Keith Vass; Dimitris Athineos; Hans Clevers; Alan R Clarke
Myc deletion rescues Apc deficiency in the small intestine.
Nature 2007;446(7136):676-9.
2007: Dina Dikovskaya; David Schiffmann; Ian P Newton; Abigail Oakley; Karin Kroboth; Owen J Sansom; Thomas J Jamieson; Valerie Meniel; Alan Clarke; Inke S Näthke
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis.
The Journal of cell biology 2007;176(2):183-95.
2006: Alan Serrels; I R J MacPherson; T R J Evans; Francis Y Lee; Edwin A Clark; Owen J Sansom; Gabrielle H Ashton; Margaret C Frame; Valerie G Brunton
Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib.
Molecular cancer therapeutics 2006;5(12):3014-22.
2006: Vanesa Muncan; Owen J Sansom; Leon Tertoolen; Toby J Phesse; Harry Begthel; Elena Sancho; Alicia M Cole; Alex Gregorieff; Ignacio Moreno de Alboran; Hans Clevers; Alan R Clarke
Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc.
Molecular and cellular biology 2006;26(22):8418-26.
2006: Owen J Sansom; Valerie Meniel; Julie A Wilkins; Alicia M Cole; Karin A Oien; Victoria Marsh; Thomas J Jamieson; Carmen Guerra; Gabrielle H Ashton; Mariano Barbacid; Alan R Clarke
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(38):14122-7.
2006: Karen R Reed; Owen J Sansom; Anthony J Hayes; Andreas J Gescher; Jeffrey M Peters; Alan R Clarke
PPARdelta status and mismatch repair mediated neoplasia in the mouse intestine.
BMC cancer 2006;6():113.
2006: Anna Prokhortchouk; Owen J Sansom; Jim Selfridge; Isabel Martín Caballero; Sergey Salozhin; Dana Aithozhina; Leandro C A Cerchietti; Fan-Guo Meng; Leonard H Augenlicht; John M Mariadason; Brian Hendrich; Ari Melnick; Egor Prokhortchouk; Alan Clarke; Adrian Bird
Kaiso-deficient mice show resistance to intestinal cancer.
Molecular and cellular biology 2006;26(1):199-208.
2005: Owen J Sansom; David F R Griffiths; Karen R Reed; Douglas J Winton; Alan R Clarke
Apc deficiency predisposes to renal carcinoma in the mouse.
Oncogene 2005;24(55):8205-10.
2005: Trevor Hay; Helen Jenkins; Owen J Sansom; Niall M B Martin; Graeme C M Smith; Alan R Clarke
Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy.
Cancer research 2005;65(22):10145-8.
2005: Owen J Sansom; Karen R Reed; Marc van de Wetering; Vanesa Muncan; Douglas J Winton; Hans Clevers; Alan R Clarke
Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.
The Journal of biological chemistry 2005;280(31):28463-7.
2005: Trevor Hay; Teresa Patrick; Douglas J Winton; Owen J Sansom; Alan R Clarke
Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells.
Oncogene 2005;24(23):3842-6.
2005: Owen J Sansom; Stefan M Bishop; Adrian Bird; Alan R Clarke
MBD2 deficiency does not accelerate p53 mediated lymphomagenesis.
Oncogene 2005;24(14):2430-2.
2005: Valérie Méniel; Trevor Hay; Anthony Douglas-Jones; Owen J Sansom; Alan R Clarke
Mutations in Apc and p53 synergize to promote mammary neoplasia.
Cancer research 2005;65(2):410-6.
2004: Karen R Reed; Owen J Sansom; Anthony J Hayes; Andreas J Gescher; Douglas J Winton; Jeffrey M Peters; Alan R Clarke
PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine.
Oncogene 2004;23(55):8992-6.
2004: Owen J Sansom; Stefan M Bishop; Adrian Bird; Alan R Clarke
MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR.
Oncogene 2004;23(33):5693-6.
2004: Owen J Sansom; Karen R Reed; Anthony J Hayes; Heather Ireland; Hannah Brinkmann; Ian P Newton; Eduard Batlle; Patricia Simon-Assmann; Hans Clevers; Inke S Nathke; Alan R Clarke; Douglas J Winton
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.
Genes & development 2004;18(12):1385-90.
2004: Heather Ireland; Richard Kemp; Carol Houghton; Louise Howard; Alan R Clarke; Owen J Sansom; Douglas J Winton
Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin.
Gastroenterology 2004;126(5):1236-46.
2004: Nuria Márquez; Sally C Chappell; Owen J Sansom; Alan R Clarke; Paul Teesdale-Spittle; Rachel J Errington; Paul J Smith
Microtubule stress modifies intra-nuclear location of Msh2 in mouse embryonic fibroblasts.
Cell cycle (Georgetown, Tex.) 2004;3(5):662-71.
2003: Nuria Márquez; Sally C Chappell; Owen J Sansom; Alan R Clarke; Jon Court; Rachel J Errington; Paul J Smith
Single cell tracking reveals that Msh2 is a key component of an early-acting DNA damage-activated G2 checkpoint.
Oncogene 2003;22(48):7642-8.
2003: Owen J Sansom; Joanna Zabkiewicz; Stefan M Bishop; Jacky Guy; Adrian Bird; Alan R Clarke
MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine.
Oncogene 2003;22(46):7130-6.
2003: Owen J Sansom; Stefan M Bishop; Helen Court; Sandra Dudley; R Michael Liskay; Alan R Clarke
Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo.
DNA repair 2003;2(9):1029-39.
2003: Owen J Sansom; Jennifer Berger; Stefan M Bishop; Brian Hendrich; Adrian Bird; Alan R Clarke
Deficiency of Mbd2 suppresses intestinal tumorigenesis.
Nature genetics 2003;34(2):145-7.
2003: Robert A Screaton; Stephan Kiessling; Owen J Sansom; Catherine B Millar; Kathryn Maddison; Adrian Bird; Alan R Clarke; Steven M Frisch
Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5211-6.
2003: Alan R Clarke; Owen J Sansom
Analyzing tumor suppressor activities in the murine small intestine.
Oncology research 2003;13(6-10):333-7.
2002: Ronald C J Gallagher; Trevor Hay; Valerie Meniel; Catherine Naughton; Thomas J Anderson; Hiroyuki Shibata; Masaki Ito; Hans Clevers; Tetsuo Noda; Owen J Sansom; John O Mason; Alan R Clarke
Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency.
Oncogene 2002;21(42):6446-57.
2002: Neil J Toft; Lucy J Curtis; Owen J Sansom; Andrea L Leitch; Andrew H Wyllie; Hein te Riele; Mark J Arends; Alan R Clarke
Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background.
Oncogene 2002;21(41):6299-306.
2002: Owen J Sansom; Alan R Clarke
The ability to engage enterocyte apoptosis does not predict long-term crypt survival in p53 and Msh2 deficient mice.
Oncogene 2002;21(38):5934-9.
2002: Catherine B Millar; Jacky Guy; Owen J Sansom; Jim Selfridge; Eilidh MacDougall; Brian Hendrich; Peter D Keightley; Stefan M Bishop; Alan R Clarke; Adrian Bird
Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.
Science (New York, N.Y.) 2002;297(5580):403-5.
2001: Owen J Sansom; Lesley Stark; Malcolm G Dunlop; Alan R Clarke
Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice.
Cancer research 2001;61(19):7060-4.
2001: Owen J Sansom; Neil J Toft; Douglas J Winton; Alan R Clarke
Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner.
Oncogene 2001;20(27):3580-4.
2000: Owen J Sansom; Alan R Clarke
P53 null mice: damaging the hypothesis?
Mutation research 2000;452(2):149-62.
2000: Neil J Toft; Owen J Sansom; R A Brookes; Mark J Arends; M Wood; G P Margison; Douglas J Winton; Alan R Clarke
In vivo administration of O(6)-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit P450-dependent activation of dacarbazine.
Carcinogenesis 2000;21(4):593-8.
1999: R Kongkanuntn; Vivien J Bubb; Owen J Sansom; Andrew H Wyllie; David J Harrison; Alan R Clarke
Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice.
Oncogene 1999;18(51):7219-25.