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Tomofumi Santa

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Shuhei Murayama; Taihei Nishiyama; Tomofumi Santa; Kaihei Takagi; Fumi Ishizuka; Masaru Kato
Delivery, stabilization, and spatiotemporal activation of cargo molecules in cells with positively charged nanoparticles.
Masaru Kato; Atsushi Shimojima; Yusuke Suwanai; Tomofumi Santa
A surfactant-based, regularly arrayed nanostructure gel matrix for migration of small molecules.
Shuhei Murayama; Akira Sano; Tomofumi Santa; Kaihei Takagi; Hirotaka Inoda; Fumi Ishizuka; Masaru Kato
Small mesh size hydrogel for functional photocontrol of encapsulated enzymes and small probe molecules.

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2012: Shuhei Murayama; Taihei Nishiyama; Tomofumi Santa; Kaihei Takagi; Fumi Ishizuka; Masaru Kato
Delivery, stabilization, and spatiotemporal activation of cargo molecules in cells with positively charged nanoparticles.
Chemical communications (Cambridge, England) 2012;48(93):11461-3.
2012: Masaru Kato; Atsushi Shimojima; Yusuke Suwanai; Tomofumi Santa
A surfactant-based, regularly arrayed nanostructure gel matrix for migration of small molecules.
Electrophoresis 2012;33(22):3339-42.
2012: Shuhei Murayama; Akira Sano; Tomofumi Santa; Kaihei Takagi; Hirotaka Inoda; Fumi Ishizuka; Masaru Kato
Small mesh size hydrogel for functional photocontrol of encapsulated enzymes and small probe molecules.
Analytical chemistry 2012;84(3):1374-9.
2011: Hirotaka Inoda; Taihei Nishiyama; Takashi Yoshikado; Yusuke Suwanai; Tomofumi Santa
Compounds having thiourea moiety as derivatization reagents in liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS): synthesis of derivatization reagents for carboxylic acids.
Biomedical chromatography : BMC 2011;25(6):635-40.
2011: Takashi Yoshikado; Tappei Takada; Takehito Yamamoto; Hiroko Yamaji; Kousei Ito; Tomofumi Santa; Hiromitsu Yokota; Yutaka Yatomi; Haruhiko Yoshida; Jun Goto; Shoji Tsuji; Hiroshi Suzuki
Itraconazole-induced cholestasis: involvement of the inhibition of bile canalicular phospholipid translocator MDR3/ABCB4.
Molecular pharmacology 2011;79(2):241-50.
2011: Tomofumi Santa
Derivatization reagents in liquid chromatography/electrospray ionization tandem mass spectrometry.
Biomedical chromatography : BMC 2011;25(1-2):1-10.
2010: Tomofumi Santa
Isothiocyanates as derivatization reagents for amines in liquid chromatography/electrospray ionization-tandem mass spectrometry.
Biomedical chromatography : BMC 2010;24(9):915-8.
2009: Tomofumi Santa; Osama Y Al-Dirbashi; Takashi Yoshikado; Takeshi Fukushima; Kazuhiro Imai
Synthesis of benzofurazan derivatization reagents for short chain carboxylic acids in liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS).
Biomedical chromatography : BMC 2009;23(4):443-6.
2008: Osama Y Al-Dirbashi; Tomofumi Santa; Mohamed S Rashed; Zuhair Al-Hassnan; Nobuyuki Shimozawa; Aziza Chedrawi; Minnie Jacob; Manhal Al-Mokhadab
Rapid UPLC-MS/MS method for routine analysis of plasma pristanic, phytanic, and very long chain fatty acid markers of peroxisomal disorders.
Journal of lipid research 2008;49(8):1855-62.
2008: Tomofumi Santa; Takeshi Fukushima; Tomoko Ichibangase; Kazuhiro Imai
Recent progress in the development of derivatization reagents having a benzofurazan structure.
Biomedical chromatography : BMC 2008;22(4):343-53.
2008: Tomofumi Santa; Osama Y Al-Dirbashi; Tomoko Ichibangase; Mohamed S Rashed; Takeshi Fukushima; Kazuhiro Imai
Synthesis of 4-[2-(N,N-dimethylamino)ethylaminosulfonyl]-7-N-methylhydrazino-2,1,3-benzoxadiazole (DAABD-MHz) as a derivatization reagent for aldehydes in liquid chromatography/electrospray ionization-tandem mass spectrometry.
Biomedical chromatography : BMC 2008;22(2):115-8.
2008: Takeshi Fukushima; Kotaro Arai; Masayuki Tomiya; Shogo Mitsuhashi; Tsukasa Sasaki; Tomofumi Santa; Kazuhiro Imai; Toshimasa Toyo'oka
Fluorescence determination of N-acetylaspartic acid in the rat cerebrum homogenate using high-performance liquid chromatography with pre-column fluorescence derivatization.
Biomedical chromatography : BMC 2008;22(1):100-5.
2007: Tomofumi Santa; Osama Y Al-Dirbashi; Tomoko Ichibangase; Takeshi Fukushima; Mohamed S Rashed; Takashi Funatsu; Kazuhiro Imai
Synthesis of benzofurazan derivatization reagents for carboxylic acids in liquid chromatography/electrospray ionization-tandem mass spectrometry.
Biomedical chromatography : BMC 2007;21(11):1207-13.
2007: Sachiko Suzuki; Satoshi Nishida; Ken-Ichi Ohno; Tomofumi Santa
Modulation of coactivator recruitment by cooperative ligand binding to human Estrogen receptor alpha and beta.
Biological & pharmaceutical bulletin 2007;30(9):1641-7.
2007: Shogo Mitsuhashi; Takeshi Fukushima; Kotaro Arai; Masayuki Tomiya; Tomofumi Santa; Kazuhiro Imai; Toshimasa Toyo'oka
Development of a column-switching high-performance liquid chromatography for kynurenine enantiomers and its application to a pharmacokinetic study in rat plasma.
Analytica chimica acta 2007;587(1):60-6.
2007: Shogo Mitsuhashi; Takeshi Fukushima; Masayuki Tomiya; Tomofumi Santa; Kazuhiro Imai; Toshimasa Toyo'oka
Determination of kynurenine levels in rat plasma by high-performance liquid chromatography with pre-column fluorescence derivatization.
Analytica chimica acta 2007;584(2):315-21.
2007: Osama Y Al-Dirbashi; Tomofumi Santa; Khalid Al-Qahtani; Mohammed Al-Amoudi; Mohamed S Rashed
Analysis of organic acid markers relevant to inherited metabolic diseases by ultra-performance liquid chromatography/tandem mass spectrometry as benzofurazan derivatives.
Rapid communications in mass spectrometry : RCM 2007;21(13):1984-90.
2006: Yuhki Tsukamoto; Tomofumi Santa; Hiroo Yoshida; Hiroshi Miyano; Takeshi Fukushima; Kazuo Hirayama; Kazuhiro Imai; Takashi Funatsu
A further study on the combined use of internal standard and isotope-labeled derivatization reagent for expansion of linear dynamic ranges in liquid chromatography-electrospray mass spectrometry.
Biomedical chromatography : BMC 2006;20(10):1049-55.
2006: Masayuki Tomiya; Takeshi Fukushima; Junko Kawai; Chiaki Aoyama; Shogo Mitsuhashi; Tomofumi Santa; Kazuhiro Imai; Toshimasa Toyo'oka
Alterations of plasma and cerebrospinal fluid glutamate levels in rats treated with the N-methyl-D-aspartate receptor antagonist, ketamine.
Biomedical chromatography : BMC 2006;20(6-7):628-33.
2006: Tomofumi Santa; Chiaki Aoyama; Takeshi Fukushima; Kazuhiro Imai; Takashi Funatsu
Suppression of thiol exchange reaction in the determination of reduced-form thiols by high-performance liquid chromatography with fluorescence detection after derivatization with fluorogenic benzofurazan reagent, 7-fluoro-2,1,3-benzoxadiazole-4-sulfonate and 4-aminosulfonyl-7-fluoro-2,1,3-benzoxadiazole.
Biomedical chromatography : BMC 2006;20(6-7):656-61.
2006: Takaaki Shirahata; Makoto Tsunoda; Tomofumi Santa; Yutaka Kirino; Satoshi Watanabe
Depletion of serotonin selectively impairs short-term memory without affecting long-term memory in odor learning in the terrestrial slug Limax valentianus.
Learning & memory (Cold Spring Harbor, N.Y.) 2006;13(3):267-70.
2006: Yuhki Tsukamoto; Tomofumi Santa; Hiroo Yoshida; Hiroshi Miyano; Takeshi Fukushima; Kazuo Hirayama; Kazuhiro Imai; Takashi Funatsu
Synthesis of the isotope-labeled derivatization reagent for carboxylic acids, 7-(N,N-dimethylaminosulfonyl)-4-(aminoethyl)piperazino-2,1,3-benzoxadiazole (d6) [DBD-PZ-NH2 (D)], and its application to the quantification and the determination of relative amount of fatty acids in rat plasma samples by high-performance liquid chromatography/mass spectrometry.
Biomedical chromatography : BMC 2006;20(4):358-64.
2005: Kazuyuki Kubota; Takeshi Fukushima; Reiko Yuji; Hiroshi Miyano; Kazuo Hirayama; Tomofumi Santa; Kazuhiro Imai
Development of an HPLC-fluorescence determination method for carboxylic acids related to the tricarboxylic acid cycle as a metabolome tool.
Biomedical chromatography : BMC 2005;19(10):788-95.
2005: Yuhki Tsukamoto; Tomofumi Santa; Hiroshi Saimaru; Kazuhiro Imai; Takashi Funatsu
Synthesis of benzofurazan derivatization reagents for carboxylic acids and its application to analysis of fatty acids in rat plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry.
Biomedical chromatography : BMC 2005;19(10):802-8.
2005: Hiroshi Hamamoto; Koushirou Kamura; Iony Manitra Razanajatovo; Kazuhisa Murakami; Tomofumi Santa; Kazuhisa Sekimizu
Effects of molecular mass and hydrophobicity on transport rates through non-specific pathways of the silkworm larva midgut.
International journal of antimicrobial agents 2005;26(1):38-42.
2005: Maki Onoda; Hidetoshi Tokuyama; Seiichi Uchiyama; Ken-ichi Mawatari; Tomofumi Santa; Kiyoko Kaneko; Kazuhiro Imai; Kazuya Nakagomi
Fluorescence enhancement by hydroperoxides based on a change in the intramolecular charge transfer character of benzofurazan.
Chemical communications (Cambridge, England) 2005;(14):1848-50.
2005: Yumiko Ohike; Koichi Kozaki; Katsuya Iijima; Masato Eto; Taro Kojima; Eijiro Ohga; Tomofumi Santa; Kazuhiro Imai; Masayoshi Hashimoto; Masao Yoshizumi; Yasuyoshi Ouchi
Amelioration of vascular endothelial dysfunction in obstructive sleep apnea syndrome by nasal continuous positive airway pressure--possible involvement of nitric oxide and asymmetric NG, NG-dimethylarginine.
Circulation journal : official journal of the Japanese Circulation Society 2005;69(2):221-6.
2004: Mitsue Saito; Tomofumi Santa; Makoto Tsunoda; Hiroshi Hamamoto; Noriko Usui
An automated analyzer for vancomycin in plasma samples by column-switching high-performance liquid chromatography with UV detection.
Biomedical chromatography : BMC 2004;18(9):735-8.
2004: Chiaki Aoyama; Tomofumi Santa; Makoto Tsunoda; Takeshi Fukushima; Chieko Kitada; Kazuhiro Imai
A fully automated amino acid analyzer using NBD-F as a fluorescent derivatization reagent.
Biomedical chromatography : BMC 2004;18(9):630-6.
2004: Erika Uchino; Takeshi Fukushima; Makoto Tsunoda; Tomofumi Santa; Kazuhiro Imai
Determination of rat blood S-D-lactoylglutathione by a column-switching high-performance liquid chromatography with precolumn fluorescence derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole.
Analytical biochemistry 2004;330(2):186-92.
2004: Hiroshi Hamamoto; Kenji Kurokawa; Chikara Kaito; Koushirou Kamura; Iony Manitra Razanajatovo; Hiroyuki Kusuhara; Tomofumi Santa; Kazuhisa Sekimizu
Quantitative evaluation of the therapeutic effects of antibiotics using silkworms infected with human pathogenic microorganisms.
Antimicrobial agents and chemotherapy 2004;48(3):774-9.
2004: Mayumi Masuda; Chifuyu Toriumi; Tomofumi Santa; Kazuhiro Imai
Fluorogenic derivatization reagents suitable for isolation and identification of cysteine-containing proteins utilizing high-performance liquid chromatography-tandem mass spectrometry.
Analytical chemistry 2004;76(3):728-35.
2003: Cheng Zhi Huang; Tomofumi Santa; Kohki Okabe; Kazuhiro Imai
Capillary electrophoresis with laser induced-fluorescence detection of profens derivatized with the water-soluble fluorogenic reagent 4-N-(4-N'-aminoethyl)piperazino-7-nitro-2,1,3-benzoxadiazole.
Journal of chromatography. A 2003;1011(1-2):193-201.
2003: Ken-ichi Ohno; Sachiko Suzuki; Takeshi Fukushima; Masako Maeda; Tomofumi Santa; Kazuhiro Imai
Study on interactions of endocrine disruptors with estrogen receptor using fluorescence polarization.
The Analyst 2003;128(8):1091-6.
2003: Sachiko Suzuki; Ken-ichi Ohno; Tomofumi Santa; Kazuhiro Imai
Study on interactions of endocrine disruptors with estrogen receptor-beta using fluorescence polarization.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 2003;19(8):1103-8.
2003: Maki Onoda; Seiichi Uchiyama; Atsushi Endo; Hidetoshi Tokuyama; Tomofumi Santa; Kazuhiro Imai
First fluorescent photoinduced electron transfer (PET) reagent for hydroperoxides.
Organic letters 2003;5(9):1459-61.
2003: Kentaro Azuma; Sachiko Suzuki; Seiichi Uchiyama; Toshi Kajiro; Tomofumi Santa; Kazuhiro Imai
A study of the relationship between the chemical structures and the fluorescence quantum yields of coumarins, quinoxalinones and benzoxazinones for the development of sensitive fluorescent derivatization reagents.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2003;2(4):443-9.
2003: Seiichi Uchiyama; Kazuyuki Takehira; Shigeru Kohtani; Kazuhiro Imai; Ryoichi Nakagaki; Seiji Tobita; Tomofumi Santa
Fluorescence on-off switching mechanism of benzofurazans.
Organic & biomolecular chemistry 2003;1(6):1067-72.
2003: Takeshi Fukushima; Noriko Usui; Tomofumi Santa; Kazuhiro Imai
Recent progress in derivatization methods for LC and CE analysis.
Journal of pharmaceutical and biomedical analysis 2003;30(6):1655-87.
2002: Kohki Okabe; Reiko Wada; Ken-ichi Ohno; Seiichi Uchiyama; Tomofumi Santa; Kazuhiro Imai
Development of hydrophilic fluorogenic derivatization reagents for thiols: 4-(N-acetylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole and 4-(N-trichloroacetylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole.
Journal of chromatography. A 2002;982(1):111-8.
2002: Tomofumi Santa; Daisuke Matsumura; ChengZhi Huang; Chieko Kitada; Kazuhiro Imai
Design and synthesis of a hydrophilic fluorescent derivatization reagent for carboxylic acids, 4-N-(4-N-aminoethyl)piperazino-7-nitro-2,1,3-benzoxadiazole (NBD-PZ-NH2), and its application to capillary electrophoresis with laser-induced fluorescence detection.
Biomedical chromatography : BMC 2002;16(8):523-8.
2002: Ken-ichi Ohno; Takeshi Fukushima; Tomofumi Santa; Nobuaki Waizumi; Hidetoshi Tokuyama; Masako Maeda; Kazuhiro Imai
Estrogen receptor binding assay method for endocrine disruptors using fluorescence polarization.
Analytical chemistry 2002;74(17):4391-6.
2002: Maki Onoda; Seiichi Uchiyama; Tomofumi Santa; Kazuhiro Imai
A photoinduced electron-transfer reagent for peroxyacetic acid, 4-ethylthioacetylamino-7-phenylsulfonyl-2,1,3-benzoxadiazole, based on the method for predicting the fluorescence quantum yields.
Analytical chemistry 2002;74(16):4089-96.
2002: Cheng Zhi Huang; Tomofumi Santa; Kazuhiro Imai
Development of 7-(N,N-dimethylaminosulfonyl)-5-N-(4-N-aminoethyl)piperazino-2,1,3-benzoxadiazole as a water-soluble fluorogenic reagent for the sensitive liquid chromatographic determination of saturated carboxylic acids.
The Analyst 2002;127(6):741-7.
2002: Natsuko Okiyama; Tomofumi Santa; Akira Toriba; Kazuya Nakagomi; Kazuhiro Imai; Hidenori Hiranuma; Hiroshi Tanaka
An automated fluorescence protein sequencer using 7-methylthio-4-(2,1,3-benzoxadiazolyl) isothiocyanate (MTBD-NCS) as an Edman reagent.
Biomedical chromatography : BMC 2002;16(3):183-6.
2002: Yasuo Dobashi; Tomofumi Santa; Kazuya Nakagomi; Kazuhiro Imai
An automated analyzer for methylated arginines in rat plasma by high-performance liquid chromatography with post-column fluorescence reaction.
The Analyst 2002;127(1):54-9.
2002: Maki Onoda; Seiichi Uchiyama; Tomofumi Santa; Kazuhiro Imai
The effects of spacer length on the fluorescence quantum yields of the benzofurazan compounds bearing a donor-acceptor system.
Luminescence : the journal of biological and chemical luminescence 2002;17(1):11-4.
2001: T Iida; Tomofumi Santa; Akira Toriba; Kohzoh Imai
Amino acid sequence and D/L-configuration determination methods for D-amino acid-containing peptides in living organisms.
Biomedical chromatography : BMC 2001;15(5):319-27.
2001: Seiichi Uchiyama; Tomofumi Santa; N Okiyama; Takeshi Fukushima; Kohzoh Imai
Fluorogenic and fluorescent labeling reagents with a benzofurazan skeleton.
Biomedical chromatography : BMC 2001;15(5):295-318.
2001: Seiichi Uchiyama; Tomofumi Santa; Kohzoh Imai
A fluorogenic reagent, 4-mercapto-7-methylthio-2,1,3-benzoxadiazole for carboxylic acids, designed by prediction of the fluorescence intensity.
Analytical chemistry 2001;73(10):2165-70.
2000: Makoto Tsunoda; Kazuko Takezawa; Tomofumi Santa; Y Ina; K Nagashima; K Ohmori; S Kobayashi; Kohzoh Imai
New approach for measurement of sympathetic nervous abnormality in conscious, spontaneously hypertensive rats.
Japanese journal of pharmacology 2000;83(1):39-45.
2000: Y Huang; Tomofumi Santa; Seiichi Uchiyama; Kohzoh Imai
Fluorescent oxidation products derived from DBD-thiocarbamoyl amino acid in the modified Edman sequencing analysis.
Biomedical chromatography : BMC 2000;14(2):133-6.
2000: Akira Toriba; K Adzuma; Tomofumi Santa; Kohzoh Imai
Development of an amino acid sequence and D/L-configuration determination method of peptide with a new fluorescence Edman reagent, 7-methylthio-4-(2,1,3-benzoxadiazolyl) isothiocyanate.
Analytical chemistry 2000;72(4):732-9.
2000: Kazuko Takezawa; Makoto Tsunoda; K Murayama; Tomofumi Santa; Kohzoh Imai
Automatic semi-microcolumn liquid chromatographic determination of catecholamines in rat plasma utilizing peroxyoxalate chemiluminescence reaction.
The Analyst 2000;125(2):293-6.
1999: Seiichi Uchiyama; H Yokosu; Tomofumi Santa; S Suzuki; Kohzoh Imai
A Fluorogenic Reagent, 7-Phenylsulfonyl-4-(2,1,3-benzoxadiazolyl) Isocyanate for Alcohols, with Development Based on the Empirical Method for Prediction.
Analytical chemistry 1999;71(23):5367-71.
1999: Makoto Tsunoda; Masahiro Kato; Takeshi Fukushima; Tomofumi Santa; Hiroshi Homma; H Yanai; T Soga; Kohzoh Imai
Determination of aspartic acid enantiomers in bio-samples by capillary electrophoresis.
Biomedical chromatography : BMC 1999;13(5):335-9.
1999: Y Huang; H Matsunaga; Akira Toriba; Tomofumi Santa; Takeshi Fukushima; Kohzoh Imai
Detection of DBD-carbamoyl amino acids in amino acid sequence and D/L configuration determination of peptides with fluorogenic Edman reagent 7-[(N,N-dimethylamino)sulfonyl]-2,1,3-benzoxadiazol-4-yl isothiocyanate.
Analytical biochemistry 1999;270(2):257-67.
1999: Makoto Tsunoda; Kazuko Takezawa; Tomofumi Santa; Kohzoh Imai
Simultaneous automatic determination of catecholamines and their 3-O-methyl metabolites in rat plasma by high-performance liquid chromatography using peroxyoxalate chemiluminescence reaction.
Analytical biochemistry 1999;269(2):386-92.
1999: P Prados; H Matsunaga; T Mori; Tomofumi Santa; Takeshi Fukushima; Hiroshi Homma; C Kasai; Kohzoh Imai
Changes of plasma L-arginine levels in spontaneously hypertensive rats under induced hypotension.
Biomedical chromatography : BMC 1999;13(1):27-32.
1998: Masahiro Kato; Takeshi Fukushima; Tomofumi Santa; K Nakashima; R Nishioka; Kohzoh Imai
Preparation and evaluation of new Pirkle type chiral stationary phases with long alkyl chains for the separation of amino acid enantiomers derivatized with NBD-F.
The Analyst 1998;123(12):2877-82.
1998: Tomofumi Santa; A Takeda; Seiichi Uchiyama; Takeshi Fukushima; Hiroshi Homma; S Suzuki; H Yokosu; C K Lim; Kohzoh Imai
N-(4-nitro-2,1,3-benzoxadiazoyl-7-yl)-N-methyl-2-aminoacetohydrazide (NBD-CO-Hz) as a precolumn fluorescent derivatization reagent for carboxylic acids in high-performance liquid chromatography.
Journal of pharmaceutical and biomedical analysis 1998;17(6-7):1065-70.
1998: Salma M Z Al-Kindy; Tomofumi Santa; Takeshi Fukushima; Hiroshi Homma; Kohzoh Imai
Enantiomeric determination of amines by high-performance liquid chromatography using chiral fluorescent derivatization reagents.
Biomedical chromatography : BMC 1998;12(5):276-80.
1998: P Prados; Tomofumi Santa; Takeshi Fukushima; Hiroshi Homma; C Kasai; M A Martin; Benito del Castillo; Kohzoh Imai
Age-related weakening of baroreflex-mediated sympathetic activity in spontaneously hypertensive rats in response to blood pressure reduction.
Hypertension research : official journal of the Japanese Society of Hypertension 1998;21(3):147-53.
1998: Yorinobu Takigawa; Hiroshi Homma; JA Lee; Takeshi Fukushima; Tomofumi Santa; Takeshi Iwatsubo; Kohzoh Imai
D-aspartate uptake into cultured rat pinealocytes and the concomitant effect on L-aspartate levels and melatonin secretion.
Biochemical and biophysical research communications 1998;248(3):641-7.
1998: T Iida; H Matsunaga; Tomofumi Santa; Takeshi Fukushima; H Homma; Kazuhiro Imai
Amino acid sequence and D/L-configuration determination of peptides utilizing liberated N-terminus phenylthiohydantoin amino acids.
Journal of chromatography. A 1998;813(2):267-75.
1998: Tomofumi Santa; J Luo; C K Lim; Kohzoh Imai
Enantiomeric separation and detection by high-performance liquid chromatography-mass spectrometry of 2-arylpropionic acids derivatized with benzofurazan fluorescent reagents.
Biomedical chromatography : BMC 1998;12(2):73-7.
1998: Y Huang; T Nishikawa; Kazue Satoh; T Iwata; Takeshi Fukushima; Tomofumi Santa; Hiroshi Homma; Kohzoh Imai
Urinary excretion of D-serine in human: comparison of different ages and species.
Biological & pharmaceutical bulletin 1998;21(2):156-62.
1998: Takeshi Fukushima; K Murayama; Tomofumi Santa; Hiroshi Homma; Kohzoh Imai
Enantiomeric separation of d-/l-norepinephrine and -epinephrine by high-performance liquid chromatography with a beta-cyclodextrin type chiral stationary phase.
Biomedical chromatography : BMC 1998;12(1):1-3.
1997: T Iida; H Matsunaga; Takeshi Fukushima; Tomofumi Santa; Hiroshi Homma; Kohzoh Imai
Complete enantiomeric separation of phenylthiocarbamoylated amino acids on a tandem column of reversed and chiral stationary phases.
Analytical chemistry 1997;69(21):4463-8.
1997: X Yang; Takeshi Fukushima; Tomofumi Santa; Hiroshi Homma; Kohzoh Imai
Enantiomeric separation and sensitive detection of propranolol, metoprolol and atenolol derivatized with a fluorogenic reagent, 4-(N-chloroformylmethyl-N-methyl)amino-7-N,N-dimethylaminosulf onyl-2,1, 3-benzoxadiazole (DBD-COCl), on cellulose chiral columns in the reversed-phase mode.
The Analyst 1997;122(11):1365-9.
1997: Kenichi Sakai; Hiroshi Homma; JA Lee; Takeshi Fukushima; Tomofumi Santa; Kei Tashiro; Takeshi Iwatsubo; Kohzoh Imai
D-aspartic acid localization during postnatal development of rat adrenal gland.
Biochemical and biophysical research communications 1997;235(2):433-6.
1997: Takeshi Fukushima; Tomofumi Santa; Hiroshi Homma; Salma M Z Al-Kindy; Kohzoh Imai
Enantiomeric Separation and Detection of 2-Arylpropionic Acids Derivatized with [(N,N-Dimethylamino)sulfonyl]benzofurazan Reagents on a Modified Cellulose Stationary Phase by High-Performance Liquid Chromatography.
Analytical chemistry 1997;69(9):1793-9.
1997: Salma M Z Al-Kindy; Tomofumi Santa; Takeshi Fukushima; Hiroshi Homma; Kohzoh Imai
1-(5-Dimethylamino-1-naphthalenesulphonyl)-(S)-3-aminopyrrolidine (DNS-Apy) as a fluorescence chiral labelling reagent for carboxylic acid enantiomers.
Biomedical chromatography : BMC 1997;11(3):137-42.
1997: P Prados; Tomofumi Santa; Hiroshi Homma; H Doi; H Narita; Benito del Castillo; M A Martin; Kohzoh Imai
Comparison of the sympathetic nervous system activity between spontaneously hypertensive and Wistar-Kyoto rats to respond to blood pressure reduction.
Biological & pharmaceutical bulletin 1997;20(4):341-4.
1997: K Hamase; Hiroshi Homma; Yorinobu Takigawa; Takeshi Fukushima; Tomofumi Santa; Kohzoh Imai
Regional distribution and postnatal changes of D-amino acids in rat brain.
Biochimica et biophysica acta 1997;1334(2-3):214-22.
1997: Kohzoh Imai; R Gohda; Takeshi Fukushima; Tomofumi Santa; Hiroshi Homma
Optimization of the reaction conditions for the peroxyoxalate chemiluminescence detection system of fluorescent compounds in HPLC.
Biomedical chromatography : BMC 1997;11(2):73.
1997: JA Lee; Hiroshi Homma; Kenichi Sakai; Takeshi Fukushima; Tomofumi Santa; Kei Tashiro; Takeshi Iwatsubo; M Yoshikawa; Kohzoh Imai
Immunohistochemical localization of D-aspartate in the rat pineal gland.
Biochemical and biophysical research communications 1997;231(2):505-8.
1996: K Imai; Takeshi Fukushima; Tomofumi Santa; Hiroshi Homma; K Hamase; K Sakai; Masahiro Kato
Analytical chemistry and biochemistry of D-amino acids.
Biomedical chromatography : BMC 1996;10(6):303-12.
1996: H Matsunaga; Tomofumi Santa; T Iida; T Fukushima; Hiroshi Homma; K Imai
Proton: a major factor for the racemization and the dehydration at the cyclization/cleavage stage in the Edman sequencing method.
Analytical chemistry 1996;68(17):2850-6.
1996: K Kimoto; R Gohda; K Murayama; Tomofumi Santa; Takeshi Fukushima; Hiroshi Homma; K Imai
Sensitive detection of near-infrared fluorescent dyes using high-performance liquid chromatography with peroxyoxalate chemiluminescence detection system.
Biomedical chromatography : BMC 1996;10(4):189-90.
1996: Tomofumi Santa; K Kimoto; Takeshi Fukushima; Hiroshi Homma; K Imai
4-(N-hydrazinoformylmethyl-N-methyl)-amino-7-N, N-dimethylaminosulphonyl-2,1,3-benzoxadiazole (DBD-CO-Hz) as a precolumn fluorescence derivatization reagent for carboxylic acids in high-performance liquid chromatography.
Biomedical chromatography : BMC 1996;10(4):183-5.
1996: H Matsunaga; T Iida; Takeshi Fukushima; Tomofumi Santa; Hiroshi Homma; K Imai
Boron trifluoride-etherate (Lewis acid) as an efficient acid at cyclization/cleavage reaction of D/L-amino acids affording the retention of their original configuration in the Edman sequencing method of peptides.
Biomedical chromatography : BMC 1996;10(2):95-6.
1995: H Matsunaga; Tomofumi Santa; K Hagiwara; Hiroshi Homma; K Imai; S Uzu; K Nakashima; S Akiyama
Development of an efficient amino acid sequencing method using fluorescent Edman reagent 7-[(N,N-dimethylamino)sulfonyl]-2,1,3-benzoxadiazol-4-yl isothiocyanate.
Analytical chemistry 1995;67(23):4276-82.
1995: Tomofumi Santa; D Yoshioka; Hiroshi Homma; K Imai; M Satoh; I Takayanagi
High-performance liquid chromatography of fullerence (C60) in plasma using ultraviolet and mass spectrometric detection.
Biological & pharmaceutical bulletin 1995;18(9):1171-4.
1995: T Fukushima; Tomofumi Santa; Hiroshi Homma; R Nagatomo; K Imai
Determination of D-amino acids in serum from patients with renal dysfunction.
Biological & pharmaceutical bulletin 1995;18(8):1130-2.
1995: K Imai; H Matsunaga; Tomofumi Santa; Hiroshi Homma
Availability of phenylisothiocyanate for the amino acid sequence/configuration determination of peptides containing D/L-amino acids.
Biomedical chromatography : BMC 1995;9(4):195-6.
1995: Masahiro Kato; Takeshi Fukushima; Tomofumi Santa; Hiroshi Homma; K Imai
Determination of D-amino acids, derivatized with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F), in wine samples by high-performance liquid chromatography.
Biomedical chromatography : BMC 1995;9(4):193-4.
1995: K Imai; H Matsunaga; Takeshi Fukushima; Tomofumi Santa; Hiroshi Homma; K Nakashima; S Akiyama
A novel method for the amino acid sequence/configuration determination of peptides containing D/L-amino acids utilizing a fluorogenic Edman reagent, 7-N,N-dimethylaminosulphonyl-4-(2,1,3-benzoxadiazolyl)isothiocyanate (DBD-NCS).
Biomedical chromatography : BMC 1995;9(3):152-4.
1995: Tomofumi Santa; D Koga; K Imai
Reversed-phase high-performance liquid chromatography of fullerenes with tetrahydrofuran-water as a mobile phase and sensitive ultraviolet or electrochemical detection.
Biomedical chromatography : BMC 1995;9(2):110-1.
1995: K Imai; Takeshi Fukushima; K Hagiwara; Tomofumi Santa
Occurrence of D-aspartic acid in rat brain pineal gland.
Biomedical chromatography : BMC 1995;9(2):106-9.
1995: Y Yamamura; Tomofumi Santa; H Kotaki; K Uchino; Yasufumi Sawada; Tatsuji Iga
Administration-route dependency of absorption of glycyrrhizin in rats: intraperitoneal administration dramatically enhanced bioavailability.
Biological & pharmaceutical bulletin 1995;18(2):337-41.
1995: D Koga; Tomofumi Santa; K Hagiwara; K Imai; H Takizawa; T Nagano; M Hirobe; M Ogawa; T Sato; K Inoue
High-performance liquid chromatography and fluorometric detection of arachidonylethanolamide (anandamide) and its analogues, derivatized with 4-(N-chloroformylmethyl-N-methyl)amino-7-N,N-dimethylaminosulp honyl-2,1 ,3- benzoxadiazole (DBD-COCl).
Biomedical chromatography : BMC 1995;9(1):56-7.
1995: Takeshi Fukushima; Masahiro Kato; Tomofumi Santa; K Imai
Enantiomeric separation and sensitive determination of D,L-amino acids derivatized with fluorogenic benzofurazan reagents on Pirkle type stationary phases.
Biomedical chromatography : BMC 1995;9(1):10-7.
1995: Y Yamamura; N Tanaka; Tomofumi Santa; H Kotaki; T Aikawa; K Uchino; Toshiaki Osuga; Yasufumi Sawada; Tatsuji Iga
The relationship between pharmacokinetic behaviour of glycyrrhizin and hepatic function in patients with acute hepatitis and liver cirrhosis.
Biopharmaceutics & drug disposition 1995;16(1):13-21.
1994: K Imai; S Higashidate; P R Prados; Tomofumi Santa; Satomi Adachi-Akahane; Taku Nagao
Relation between blood pressure and plasma catecholamine concentration after administration of calcium antagonists to rats.
Biological & pharmaceutical bulletin 1994;17(7):907-10.
1993: N Tanaka; Y Yamamura; Tomofumi Santa; H Kotaki; K Uchino; Yasufumi Sawada; T Aikawa; Toshiaki Osuga; Tatsuji Iga
Pharmacokinetic profiles of glycyrrhizin in patients with chronic hepatitis.
Biopharmaceutics & drug disposition 1993;14(7):609-14.
1993: J Kawakami; Y Yamamura; Tomofumi Santa; H Kotaki; K Uchino; Yasufumi Sawada; Tatsuji Iga
Kinetic analysis of glycyrrhetic acid, an active metabolite of glycyrrhizin, in rats: role of enterohepatic circulation.
Journal of pharmaceutical sciences 1993;82(3):301-5.
1992: Y Yamamura; J Kawakami; Tomofumi Santa; H Kotaki; K Uchino; Yasufumi Sawada; N Tanaka; Tatsuji Iga
Pharmacokinetic profile of glycyrrhizin in healthy volunteers by a new high-performance liquid chromatographic method.
Journal of pharmaceutical sciences 1992;81(10):1042-6.
1991: Y Yamamura; J Kawakami; Tomofumi Santa; H Kotaki; K Uchino; Yasufumi Sawada; Tatsuji Iga
Selective high-performance liquid chromatographic method for the determination of glycyrrhizin and glycyrrhetic acid-3-O-glucuronide in biological fluids: application of ion-pair extraction and fluorescence labelling agent.
Journal of chromatography 1991;567(1):151-60.