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Derek Sant'Angelo

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Elisa Monzon-Casanova; Ingrid Müller; Daniel Paletta; Elwira Pyz; Derek B Sant'Angelo; Lisa Starick; Thomas Herrmann
Direct identification of rat iNKT cells reveals remarkable similarities to human iNKT cells and a profound deficiency in LEW rats.
Puspa Thapa; Rhianna Sundsbak; Sarah Tangen; Joshua Anderson; Joy Das; Stephen Desiderio; Scott Hiebert; Douglas McWilliams; Molly Nelson-Holte; Derek B Sant'Angelo; Michael Shapiro; Virginia Smith Shapiro
The transcriptional repressor NKAP is required for the development of iNKT cells.
Yu Qiao; Derek B Sant'Angelo; Pamela L Schwartzberg; Hanief Sofi; Gretta L Stritesky; Hung-Sia Teh; David L Wiest; Lingqiao Zhu; Xi He; Kristin A Hogquist; Reiko Horai; Dietmar J Kappes; Philip D King; Philip E Lapinski; Kristen Mueller; Cheong-Hee Chang
Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.

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2013: Elisa Monzon-Casanova; Ingrid Müller; Daniel Paletta; Elwira Pyz; Derek B Sant'Angelo; Lisa Starick; Thomas Herrmann
Direct identification of rat iNKT cells reveals remarkable similarities to human iNKT cells and a profound deficiency in LEW rats.
European journal of immunology 2013;43(2):404-15.
2013: Puspa Thapa; Rhianna Sundsbak; Sarah Tangen; Joshua Anderson; Joy Das; Stephen Desiderio; Scott Hiebert; Douglas McWilliams; Molly Nelson-Holte; Derek B Sant'Angelo; Michael Shapiro; Virginia Smith Shapiro
The transcriptional repressor NKAP is required for the development of iNKT cells.
Nature communications 2013;4():1582.
2012: Yu Qiao; Derek B Sant'Angelo; Pamela L Schwartzberg; Hanief Sofi; Gretta L Stritesky; Hung-Sia Teh; David L Wiest; Lingqiao Zhu; Xi He; Kristin A Hogquist; Reiko Horai; Dietmar J Kappes; Philip D King; Philip E Lapinski; Kristen Mueller; Cheong-Hee Chang
Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(40):16264-9.
2011: Aimee M Beaulieu; Derek B Sant'Angelo
The BTB-ZF family of transcription factors: key regulators of lineage commitment and effector function development in the immune system.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(6):2841-7.
2011: Yacine M Amrani; Eric S Alonzo; Jonathan Gill; Armine Matevossian; Malcolm A Moore; Christopher Y Park; Derek B Sant'Angelo; Jae-Hung Shieh; Chingwen Yang; Lisa K Denzin
The Paf oncogene is essential for hematopoietic stem cell function and development.
The Journal of experimental medicine 2011;208(9):1757-65.
2011: Scott M Gordon; Shannon A Carty; Jiyeon S Kim; Tao Zou; Jennifer Smith-Garvin; Eric S Alonzo; Ethan Haimm; Derek B Sant'Angelo; Gary A Koretzky; Steven L Reiner; Martha S Jordan
Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(8):4573-8.
2011: Eric S Alonzo; Derek B Sant'Angelo
Development of PLZF-expressing innate T cells.
Current opinion in immunology 2011;23(2):220-7.
2011: Maggie Eidson; Bernhard Horsthemke; Aimee M Beaulieu; Steven E Carsons; Peggy K Crow; Justin Wahlstrom; Dagmar Wieczorek; Jedd D Wolchok; Jianda Yuan; Bushra Zaidi; Derek B Sant'Angelo
Altered development of NKT cells, γδ T cells, CD8 T cells and NK cells in a PLZF deficient patient.
PloS one 2011;6(9):e24441.
2011: Jianwei Li; Omar Vandal; Derek B Sant'Angelo
TCR affinity for self-ligands influences the development and function of encephalitogenic T cells.
PloS one 2011;6(3):e17702.
2010: Rupali Das; Derek B Sant'Angelo; Kim E Nichols
Transcriptional control of invariant NKT cell development.
Immunological reviews 2010;238(1):195-215.
2010: Damian Kovalovsky; Eric S Alonzo; Olisambu U. Uche; Maggie Eidson; Kim E Nichols; Derek B Sant'Angelo
PLZF induces the spontaneous acquisition of memory/effector functions in T cells independently of NKT cell-related signals.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(12):6746-55.
2010: Woelsung Yi; Nilufer P Seth; Tom Martillotti; Kai W Wucherpfennig; Derek B Sant'Angelo; Lisa K Denzin
Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence.
The Journal of clinical investigation 2010;120(4):1324-36.
2010: Eric S Alonzo; Rachel A Gottschalk; Joy Das; Takeshi Egawa; Robin M Hobbs; Pier Paolo Pandolfi; Pablo Pereira; Kim E Nichols; Gary A Koretzky; Martha S Jordan; Derek B Sant'Angelo
Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(3):1268-79.
2010: Stefan Knirr; Janette Gomos-Klein; Blanca E Andino; Faith Harrow; Karl F Erhard; Damian Kovalovsky; Derek B Sant'Angelo; Benjamin D Ortiz
Ectopic T cell receptor-α locus control region activity in B cells is suppressed by direct linkage to two flanking genes at once.
PloS one 2010;5(11):e15527.
2010: Hye-Jung Kim; Eric S Alonzo; Guillaume Dorothee; Jeffrey W Pollard; Derek B Sant'Angelo
Selective depletion of eosinophils or neutrophils in mice impacts the efficiency of apoptotic cell clearance in the thymus.
PloS one 2010;5(7):e11439.
2010: Damian Kovalovsky; Mark Pezzano; Benjamin D Ortiz; Derek B Sant'Angelo
A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway.
PloS one 2010;5(1):e8675.
2009: Eirini P Papapetrou; Damian Kovalovsky; Laurent Beloeil; Derek B Sant'Angelo; Michel Sadelain
Harnessing endogenous miR-181a to segregate transgenic antigen receptor expression in developing versus post-thymic T cells in murine hematopoietic chimeras.
The Journal of clinical investigation 2009;119(1):157-68.
2008: Milica Stojakovic; Laura I Salazar-Fontana; Zohreh Tatari-Calderone; Vladimir P Badovinac; Fabio R Santori; Damian Kovalovsky; Derek B Sant'Angelo; John T Harty; Stanislav Vukmanovic
Adaptable TCR avidity thresholds for negative selection.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):6770-8.
2008: Damian Kovalovsky; Olisambu U. Uche; Sonia Eladad; Robin M Hobbs; Woelsung Yi; Eric Alonzo; Kevin Chua; Maggie Eidson; Hye-Jung Kim; Jin S Im; Pier Paolo Pandolfi; Derek B Sant'Angelo
The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions.
Nature immunology 2008;9(9):1055-64.
2008: Johannes L Zakrzewski; David Suh; John C Markley; Odette M Smith; Christopher King; Gabrielle Goldberg; Robert R Jenq; Amanda M Holland; Jeremy Grubin; Javier Cabrera Perez; Renier J Brentjens; Sydney X Lu; Gabrielle Rizzuto; Derek B Sant'Angelo; Isabelle Riviere; Michel Sadelain; Glenn Heller; Juan Carlos Zúñiga-Pflücker; Chen Lu; Marcel R M van den Brink
Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors.
Nature biotechnology 2008;26(4):453-61.
2006: Amariliz Rivera; Grace Ro; Heather L Van Epps; Tyler Simpson; Ingrid Leiner; Derek B Sant'Angelo; Eric G Pamer
Innate immune activation and CD4+ T cell priming during respiratory fungal infection.
Immunity 2006;25(4):665-75.
2005: Wei Li; Moon Gyo Kim; Tania S Gourley; Brian P McCarthy; Derek B Sant'Angelo; Cheong-Hee Chang
An alternate pathway for CD4 T cell development: thymocyte-expressed MHC class II selects a distinct T cell population.
Immunity 2005;23(4):375-86.
2005: Amy L Stolzer; Michel Sadelain; Derek B Sant'Angelo
Fulminant experimental autoimmune encephalo-myelitis induced by retrovirally mediated TCR gene transfer.
European journal of immunology 2005;35(6):1822-30.
2005: Hye-Jung Kim; Donglin Guo; Derek B Sant'Angelo
Coevolution of TCR-MHC interactions: conserved MHC tertiary structure is not sufficient for interactions with the TCR.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(20):7263-7.
2005: Lisa K Denzin; Derek B Sant'Angelo
Dipping into the cytosol to broaden the MHC class II peptide repertoire.
Immunity 2005;22(5):536-7.
2004: Tao Dao; Donglin Guo; Alexander Ploss; Amy L Stolzer; Carolyn Saylor; Tamar E Boursalian; Jin Seon Im; Derek B Sant'Angelo
Development of CD1d-restricted NKT cells in the mouse thymus.
European journal of immunology 2004;34(12):3542-52.
2004: Jennifer L Fallas; Helen M Tobin; Olivia Lou; Donglin Guo; Derek B Sant'Angelo; Lisa K Denzin
Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1549-60.
2003: Julie M. Blander; Derek B Sant'Angelo; Daniela Metz; Sang-Won Kim; Richard A Flavell; Kim Bottomly; Charles A Janeway
A pool of central memory-like CD4 T cells contains effector memory precursors.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):2940-8.
2003: Tao Dao; Julie M. Blander; Derek B Sant'Angelo
Recognition of a specific self-peptide: self-MHC class II complex is critical for positive selection of thymocytes expressing the D10 TCR.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):48-54.
2002: Derek B Sant'Angelo; Eve Robinson; Charles A Janeway; Lisa K Denzin
Recognition of core and flanking amino acids of MHC class II-bound peptides by the T cell receptor.
European journal of immunology 2002;32(9):2510-20.
2002: Derek B Sant'Angelo; Charles A Janeway
Negative selection of thymocytes expressing the D10 TCR.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6931-6.
2001: Derek B Sant'Angelo; Peter Cresswell; Charles A Janeway; Lisa K Denzin
Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6824-9.
2001: Christophe Viret; Derek B Sant'Angelo; X He; H Ramaswamy; Charles A Janeway
A role for accessibility to self-peptide-self-MHC complexes in intrathymic negative selection.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4429-37.
2000: Julie M. Blander; Derek B Sant'Angelo; Kim Bottomly; Charles A Janeway
Alteration at a single amino acid residue in the T cell receptor alpha chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2.
The Journal of experimental medicine 2000;191(12):2065-74.
2000: M H Levine; Ann M Haberman; Derek B Sant'Angelo; Lynn G Hannum; M P Cancro; Charles A Janeway; Mark J Shlomchik
A B-cell receptor-specific selection step governs immature to mature B cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2743-8.
1998: Derek B Sant'Angelo; Bruno LUCAS; PG Waterbury; B Cohen; Thea Brabb; Joan Goverman; Ronald N Germain; Charles A Janeway
A molecular map of T cell development.
Immunity 1998;9(2):179-86.
1997: Soon-Cheol Hong; Derek B Sant'Angelo; Bonnie N Dittel; Ruslan Medzhitov; S T Yoon; PG Waterbury; Charles A Janeway
The orientation of a T cell receptor to its MHC class II:peptide ligands.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4395-402.
1997: Lisa K Denzin; Derek B Sant'Angelo; C Hammond; MJ Surman; Peter Cresswell
Negative regulation by HLA-DO of MHC class II-restricted antigen processing.
Science (New York, N.Y.) 1997;278(5335):106-9.
1997: Derek B Sant'Angelo; PG Waterbury; B E Cohen; W D Martin; Luc Van Kaer; Adrian C Hayday; Charles A Janeway
The imprint of intrathymic self-peptides on the mature T cell receptor repertoire.
Immunity 1997;7(4):517-24.
1997: Bonnie N Dittel; Derek B Sant'Angelo; Charles A Janeway
Peptide antagonists inhibit proliferation and the production of IL-4 and/or IFN-gamma in T helper 1, T helper 2, and T helper 0 clones bearing the same TCR.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4065-73.
1997: Charles A Janeway; Alexander V Chervonsky; Derek B Sant'Angelo
T-cell receptors: is the repertoire inherently MHC-specific?
Current biology : CB 1997;7(5):R299-300.
1997: Thea Brabb; Eric S Huseby; Todd M Morgan; Derek B Sant'Angelo; J Kirchner; A G Farr; Joan Goverman
Thymic stromal organization is regulated by the specificity of T cell receptor/major histocompatibility complex interactions.
European journal of immunology 1997;27(1):136-46.
1996: Derek B Sant'Angelo; G Waterbury; Paula Preston-Hurlburt; S T Yoon; Ruslan Medzhitov; Soon-Cheol Hong; Charles A Janeway
The specificity and orientation of a TCR to its peptide-MHC class II ligands.
Immunity 1996;4(4):367-76.
1995: Antonio Campos-Neto; Lynn Soong; J L Cordova; Derek B Sant'Angelo; Yasir A W Skeiky; Nancy H Ruddle; Steven G Reed; C Janeway; Diane McMahon-Pratt
Cloning and expression of a Leishmania donovani gene instructed by a peptide isolated from major histocompatibility complex class II molecules of infected macrophages.
The Journal of experimental medicine 1995;182(5):1423-33.
1995: Stephanie L Constant; Derek B Sant'Angelo; T Pasqualini; T Taylor; D Levin; Richard A Flavell; Kim Bottomly
Peptide and protein antigens require distinct antigen-presenting cell subsets for the priming of CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(10):4915-23.
1992: Derek B Sant'Angelo; W P Lafuse; H C Passmore
Evidence that nucleotide sequence identity is a requirement for meiotic crossing over within the mouse Eb recombinational hot spot.
Genomics 1992;13(4):1334-6.
1992: E C Bryda; J A DePari; Derek B Sant'Angelo; D B Murphy; H C Passmore
Multiple sites of crossing over within the Eb recombinational hotspot in the mouse.
Mammalian genome : official journal of the International Mammalian Genome Society 1992;2(2):123-9.