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Shyam Biswal

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Ulaganathan Mabalirajan; Rakhshinda Rehman; Suchita Singh; Vijay P Singh; Anurag Agrawal; Tanveer Ahmad; Jyotirmoi Aich; Shyam Biswal; Amit K Dinda; Kritika Khanna; Manish Kumar; SARVESH KUMAR; Geeta Leishangthem; Balaram Ghosh
Linoleic acid metabolite drives severe asthma by causing airway epithelial injury.
SARVESH KUMAR; Virinder S Parmar; Ashok K Prasad; Brajendra K Singh; Shyam Biswal; Balaram Ghosh
Ethyl 3',4',5'-trimethoxythionocinnamate modulates NF-κB and Nrf2 transcription factors.
Ulaganathan Mabalirajan; Rakhshinda Rehman; Suchita Singh; SARVESH KUMAR; Geeta Leishangthem; Anurag Agrawal; Tanveer Ahmad; Shyam Biswal; Amit Kumar Dinda; Balaram Ghosh
12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.

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All Publications

2013: Ulaganathan Mabalirajan; Rakhshinda Rehman; Suchita Singh; Vijay P Singh; Anurag Agrawal; Tanveer Ahmad; Jyotirmoi Aich; Shyam Biswal; Amit K Dinda; Kritika Khanna; Manish Kumar; SARVESH KUMAR; Geeta Leishangthem; Balaram Ghosh
Linoleic acid metabolite drives severe asthma by causing airway epithelial injury.
Scientific reports 2013;3():1349.
2013: SARVESH KUMAR; Virinder S Parmar; Ashok K Prasad; Brajendra K Singh; Shyam Biswal; Balaram Ghosh
Ethyl 3',4',5'-trimethoxythionocinnamate modulates NF-κB and Nrf2 transcription factors.
European journal of pharmacology 2013;700(1-3):32-41.
2013: Ulaganathan Mabalirajan; Rakhshinda Rehman; Suchita Singh; SARVESH KUMAR; Geeta Leishangthem; Anurag Agrawal; Tanveer Ahmad; Shyam Biswal; Amit Kumar Dinda; Balaram Ghosh
12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.
Scientific reports 2013;3():1540.
2013: SARVESH KUMAR; Ulanganathan Mabalirajan; Virinder S Parmar; Ashok K Prasad; Rakhshinda Rehman; Brajendra K Singh; Shyam Biswal; Balaram Ghosh
A novel cinnamate derivative attenuates asthma features and reduces bronchial epithelial injury in mouse model.
International immunopharmacology 2013;15(1):150-9.
2012: Rajesh K Thimmulappa; Joseph L Witztum; Xing Gang; Jung-Hyun Kim; Thomas E Sussan; Shyam Biswal
Oxidized phospholipids impair pulmonary antibacterial defenses: evidence in mice exposed to cigarette smoke.
Biochemical and biophysical research communications 2012;426(2):253-9.
2012: Ashish Jachak; Samuel Lai; Nina Markovic; Jung Soo Suk; Shyam Biswal; Patrick N Breysse; Kaoru Hida; Justin Hanes
Transport of metal oxide nanoparticles and single-walled carbon nanotubes in human mucus.
Nanotoxicology 2012;6(6):614-22.
2012: Andrew J Sandford; Mateusz Siedlinski; Vivien Wong; Loubna Akhabir; Nicholas R Anthonisen; H Marike Boezen; John E Connett; Jian-Qing He; Deepti Malhotra; Peter D Paré; Dirkje S Postma; Shyam Biswal
NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease.
Physiological genomics 2012;44(15):754-63.
2012: Shyam Biswal; Rajesh K Thimmulappa; Christopher J Harvey
Experimental therapeutics of Nrf2 as a target for prevention of bacterial exacerbations in COPD.
Proceedings of the American Thoracic Society 2012;9(2):47-51.
2012: SARVESH KUMAR; Vineet Kumar; Yogesh Kumar; Shashwat Malhotra; Sanjay V Malhotra; Mukesh K Pandey; Shyam Biswal; Anthony L DePass; Balaram Ghosh; Rajni Jain; Amit Kumar; Ashok K Prasad; Chandra Shekhar Reddy L; Sunil K Sharma; Brajendra K Singh; Rajesh K Thimmulappa; Erik Van Der Eycken; Virinder S Parmar
Arylalkyl ketones, benzophenones, desoxybenzoins and chalcones inhibit TNF-α induced expression of ICAM-1: structure-activity analysis.
Archiv der Pharmazie 2012;345(5):368-77.
2012: Kavita Bhalla; Shyam Biswal; Ruby E Dewi; Olga Goloubeva; Bor-Jang Hwang; Neeraj Saxena; William Twaddel; Kwok-Kin Wong; Geoffrey D Girnun
Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis.
Cancer prevention research (Philadelphia, Pa.) 2012;5(4):544-52.
2012: Narsa Reddy Machireddy; Suryanaraya Vegiraju; Navas-Acien Ana; Sergei Atamas; Shyam Biswal; Ashley Irving; Irina G Luzina; Wayne Mitzner; Bogdan C Paun; SEKHAR POTHIREDDY
Targeted deletion of Jun/AP-1 in alveolar epithelial cells causes progressive emphysema and worsens cigarette smoke-induced lung inflammation.
The American journal of pathology 2012;180(2):562-74.
2012: Ponvijay Kombairaju; JINFANG MA; Anju Singh; Rajesh K Thimmulappa; Shengbin G Yan; Edward Gabrielson; Shyam Biswal
Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer.
Journal of carcinogenesis 2012;11():8.
2012: George K Acquaah-Mensah; Deepti Malhotra; Jason E McDermott; Madhulika Vulimiri; Shyam Biswal
Suppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease.
PLoS computational biology 2012;8(7):e1002597.
2012: Kassim Traore; Shyam Biswal; Rajesh K Thimmulappa; Barry R Zirkin; Michael A Trush
Upregulation of TLR1, TLR2, TLR4, and IRAK-2 Expression During ML-1 Cell Differentiation to Macrophages: Role in the Potentiation of Cellular Responses to LPS and LTA.
ISRN oncology 2012;2012():641246.
2012: Dimas Yusuf; Mariastella Zannini; Xiao Yu Cindy Zhang; Chunyan Zhao; Carol F Webb; Elizabeth Wederell; Michael Wegner; Roland H Wenger; Miranda S C Wilson; Matthew E Witek; Mark W Woodcroft; Jarrod Bailey; Alison H Banham; Leonardo L Beccari; Bérénice A Benayoun; Shyam Biswal; Marissa Cathleen Blank; Bianca Blom; Eugene Bolotin; Gaylor Boulay; Paola Bovolenta; Philip H Bradley; Mary B Breslin; Jan J Brosens; Philip J Brown; Stefanie L Butland; Gieri Camenisch; Rumela Chakrabarti; Harini Chakravarthy; Edwin Chen; Warren A Cheung; Stephanie C Colvin; Rebecca L Cullum; Karin Dahlman-Wright; Juliet M Daniel; Tiziana de Cristofaro; Charles N de Leeuw; Jason P DeBruyne; Luis del Peso; Christopher T D Dickman; Astrid Eijkelenboom; G Nicholas Europe-Finner; Peggy J Farnham; Scott Ferrell; Douglas Forrest; Seth Frietze; Debra L Fulton; Richard M Gronostajski; Lars Grontved; Oliver Hankinson; Christopher J Harvey; Christophe Héligon; Robert F Hevner; John B Hogenesch; Pamela A Hoodless; Juan Hou; Margaret R Hough; Padma-Sheela Jayaraman; Magdalena Karolczak-Bayatti; Julien J Karrich; Ralf Kist; Eric W-F Lam; Michael S Lan; David Laperrière; David P LeBrun; Dominique Leprince; Michaela Liedtke; Jonathan S Lim; Xin M Luo; Sylvie Mader; M Michela Mancarelli; Susanne Mandrup; Raquel Marco-Ferreres; Michal Mikula; Kathleen Joyce Millen; Yuriko Mishima; Lara J Monteiro; Rachel D Mullen; Kyster K Nanan; Peter John Noy; Henriette O'Geen; Sam W Z Olechnowicz; Jerzy Ostrowski; Jason Park; Daniel J Peet; Elodie Portales-Casamar; Kelly L Prince; Marrit Putker; Venu Raman; Oscar H P Ramos; SEKHAR POTHIREDDY; Simon J Rhodes; Angie Rizzino; Marieke Rozendaal; Gerhart U Ryffel; Jake M Schnabl; Helma D C Schwenen; David S Sharlin; Elizabeth M Simpson; Satrajit Sinha; Frances M Sladek; Yunfu Sun; Magdalena I Swanson; Michael Taggart; Amy Ticoll; Bruce E Torbett; Mario P Tschan; Capucine Van Rechem; Mireille Vasseur-Cognet; Michelle Vaz; Reiner A Veitia; Farhad Vesuna; Scott A Waldman; Wyeth W Wasserman
The transcription factor encyclopedia.
Genome biology 2012;13(3):R24.
2011: Akil A Merchant; William Matsui; Anju Singh; Shyam Biswal
The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels.
Blood 2011;118(25):6572-9.
2011: Narsa Reddy Machireddy; Shyam Biswal; Thomas J Mariani; Haranatha R Potteti; SEKHAR POTHIREDDY
Conditional deletion of Nrf2 in airway epithelium exacerbates acute lung injury and impairs the resolution of inflammation.
American journal of respiratory cell and molecular biology 2011;45(6):1161-8.
2011: Deepti Malhotra; Nicolas Mercado; Rajesh K Thimmulappa; Robert Wise; DAVID FELLER-KOPMAN; Kazuhiro Ito; Ponvijay Kombairaju; SARVESH KUMAR; JINFANG MA; Peter Barnes; Shyam Biswal
Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients.
The Journal of clinical investigation 2011;121(11):4289-302.
2011: SARVESH KUMAR; Shashwat Malhotra; Carl E Olsen; Virinder S Parmar; Ashok K Prasad; Brajendra K Singh; Rajesh K Thimmulappa; Erik Van Der Eycken; Pragya Arya; Shyam Biswal; Anthony L DePass; Balaram Ghosh
Novel natural product-based cinnamates and their thio and thiono analogs as potent inhibitors of cell adhesion molecules on human endothelial cells.
European journal of medicinal chemistry 2011;46(11):5498-511.
2011: Xiaoni Kong; SEKHAR POTHIREDDY; Florin Craciun; Ponvijay Kombairaju; Rajesh K Thimmulappa; Daniel Remick; Anju Singh; Christopher Harvey; Shyam Biswal
Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis.
American journal of respiratory and critical care medicine 2011;184(8):928-38.
2011: Jonathan K Alder; Wayne Mitzner; Erin M Parry; Nini Guo; Rubin M Tuder; Collin J Anderson; Amany I Gorgy; Frant Kembou; Michael F Walsh; Shyam Biswal; Thomas Sussan; Mary Armanios
Telomere length is a determinant of emphysema susceptibility.
American journal of respiratory and critical care medicine 2011;184(8):904-12.
2011: Weisong Zhou; Vasiliy V Polosukhin; Thomas Sussan; Shinji Toki; Pingsheng Wu; Shyam Biswal; Timothy S Blackwell; Robert D Collins; Dustin R Dowell; Mark W Geraci; Kasia Goleniewska; William E Lawson; Jason D Morrow; Dawn C Newcomb; Jamye O'Neal; R Stokes Peebles
PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression.
American journal of physiology. Lung cellular and molecular physiology 2011;301(4):L615-22.
2011: Bing Wang; Shyam Biswal; Wangsen Cao; Sylvain Doré
Carbon monoxide-activated Nrf2 pathway leads to protection against permanent focal cerebral ischemia.
Stroke; a journal of cerebral circulation 2011;42(9):2605-10.
2011: Sharon A McGrath-Morrow; Wayne Mitzner; Enid R Neptune; Michael O'Reilly; Robert Wise; Min Yee; J Michael Collaco; Thomas Lauer; Shyam Biswal
Neonatal hyperoxia contributes additively to cigarette smoke-induced chronic obstructive pulmonary disease changes in adult mice.
American journal of respiratory cell and molecular biology 2011;45(3):610-6.
2011: Sharon A McGrath-Morrow; Wayne Mitzner; Enid R Neptune; Robert Wise; J Michael Collaco; Thomas Lauer; Deepti Malhotra; Shyam Biswal
Exposure to neonatal cigarette smoke causes durable lung changes but does not potentiate cigarette smoke-induced chronic obstructive pulmonary disease in adult mice.
Experimental lung research 2011;37(6):354-63.
2011: SANJEEV NOEL; Mary Jane C Ong; Joy Saams; Shyam Biswal; Patrick N Breysse; Gregory B Diette; Elizabeth C Matsui
Opposing effects of nasal epithelial NAD(P)H dehydrogenase quinine 1 and heme oxygenase 1 expression on upper and lower airway symptoms in adolescents with asthma.
The Journal of allergy and clinical immunology 2011;128(2):422-4.e3.
2011: Vineet Kumar; Shyam Biswal; Mohammad Hassan; Amit Kumar; SARVESH KUMAR; Virinder S Parmar; Sunil K Sharma; Rajesh K Thimmulappa; Hailong Wu; Sanjay V Malhotra
Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.
Journal of medicinal chemistry 2011;54(12):4147-59.
2011: Mukesh K Pandey; SARVESH KUMAR; Rajesh K Thimmulappa; Virinder S Parmar; Shyam Biswal; Arthur C Watterson
Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2011;43(1-2):16-24.
2011: Christopher J Harvey; Rajesh K Thimmulappa; Sanjay Sethi; Xiaoni Kong; Lonny Brett Yarmus; Robert H Brown; DAVID FELLER-KOPMAN; Robert Wise; Shyam Biswal
Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model.
Science translational medicine 2011;3(78):78ra32.
2011: Nicolas Mercado; Rajesh K Thimmulappa; Catherine M R Thomas; Peter S Fenwick; Kirandeep K Chana; Louise E Donnelly; Shyam Biswal; Kazuhiro Ito; Peter J Barnes
Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress.
Biochemical and biophysical research communications 2011;406(2):292-8.
2011: QING KAY LI; Anju Singh; Shyam Biswal; Frederic B Askin; Edward Gabrielson
KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma.
Journal of human genetics 2011;56(3):230-4.
2011: Wanchang Cui; JINFANG MA; Yulei Wang; Shyam Biswal
Plasma miRNA as biomarkers for assessment of total-body radiation exposure dosimetry.
PloS one 2011;6(8):e22988.
2011: Meixia Gao; K Macri; CURT REYNOLDS; Anju Singh; Vandana Singhal; Shyam Biswal; Ernst Wm Spannhake
Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system.
Respiratory research 2011;12():92.
2010: Anju Singh; Manish Bodas; Nobunao Wakabayashi; Fred Bunz; Shyam Biswal
Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance.
Antioxidants & redox signaling 2010;13(11):1627-37.
2010: Zahoor Ahmad Shah; Rung-chi Li; Abdullah Shafique Ahmad; Thomas W Kensler; Masayuki Yamamoto; Shyam Biswal; Sylvain Dore
The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010;30(12):1951-61.
2010: Deepti Malhotra; Elodie Portales-Casamar; Anju Singh; Siddhartha Srivastava; David Arenillas; Christine Happel; Casper Shyr; Nobunao Wakabayashi; Thomas W Kensler; Wyeth W Wasserman; Shyam Biswal
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis.
Nucleic acids research 2010;38(17):5718-34.
2010: Tirumalai Rangasamy; Marc A Williams; Stephen Bauer; Michael A Trush; Jason Emo; Steve N Georas; Shyam Biswal
Nuclear erythroid 2 p45-related factor 2 inhibits the maturation of murine dendritic cells by ragweed extract.
American journal of respiratory cell and molecular biology 2010;43(3):276-85.
2010: Anju Singh; Hailong Wu; Pingwu Zhang; Christine Happel; JINFANG MA; Shyam Biswal
Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype.
Molecular cancer therapeutics 2010;9(8):2365-76.
2010: Luisa M Solis; Carmen Behrens; Wenli Dong; Milind Suraokar; Natalie C Ozburn; Cesar A Moran; Alejandro Corvalan; Shyam Biswal; Stephen G Swisher; B Nebiyou Bekele; John D Minna; David J Stewart; Ignacio I Wistuba
Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(14):3743-53.
2010: Xiaoni Kong; Rajesh K Thimmulappa; Ponvijay Kombairaju; Shyam Biswal
NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(1):569-77.
2010: Toshinori Yoshida; Igor Mett; Anil K Bhunia; Joel Bowman; Mario Perez; Li Zhang; Aneta Gandjeva; Lijie Zhen; Ugonma Chukwueke; Tianzhi Mao; Amy Richter; Emile Brown; Hagit Ashush; Natalie Notkin; Anna Gelfand; Rajesh K Thimmulappa; Tirumalai Rangasamy; Thomas Sussan; Gregory Cosgrove; Majd Mouded; Steven D Shapiro; Irina Petrache; Shyam Biswal; Elena Feinstein; Rubin M Tuder
Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema.
Nature medicine 2010;16(7):767-73.
2010: Usha Singh; Ajit Kumar; Rajesh Sinha; Sushma Manral; Shvetambri Arora; Sant Ram; Rakesh K Mishra; Prachi Gupta; Surendra K Bansal; Ashok K Prasad; Shyam Biswal; Virinder S Parmar; Hanumantharao G Raj
Calreticulin transacetylase catalyzed modification of the TNF-alpha mediated pathway in the human peripheral blood mononuclear cells by polyphenolic acetates.
Chemico-biological interactions 2010;185(3):263-70.
2010: David J Blake; Anju Singh; Ponvijay Kombairaju; Deepti Malhotra; Thomas J Mariani; Rubin M Tuder; Edward Gabrielson; Shyam Biswal
Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation.
American journal of respiratory cell and molecular biology 2010;42(5):524-36.
2010: Marisol Cano; Rajesh Thimmalappula; Masashi Fujihara; Norihiro Nagai; Michael Sporn; A Wang; Arthur H Neufeld; Shyam Biswal; James T Handa
Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration.
Vision research 2010;50(7):652-64.
2010: Pingwu Zhang; Anju Singh; Srinivasan Yegnasubramanian; David Esopi; Ponvijay Kombairaju; Manish Bodas; Hailong Wu; G Steven Bova; Shyam Biswal
Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth.
Molecular cancer therapeutics 2010;9(2):336-46.
2010: Nobunao Wakabayashi; Soona Shin; Stephen L Slocum; Elin S Agoston; Junko Wakabayashi; Mi-Kyoung Kwak; Vikas Misra; Shyam Biswal; Masayuki Yamamoto; Thomas W Kensler
Regulation of notch1 signaling by nrf2: implications for tissue regeneration.
Science signaling 2010;3(130):ra52.
2009: Deepti Malhotra; Rajesh K Thimmulappa; Neeraj Vij; Ana Navas-Acien; Thomas Sussan; Salim Merali; Li Zhang; Steven G Kelsen; Allen C Myers; Robert Wise; Rubin M Tuder; Shyam Biswal
Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity.
American journal of respiratory and critical care medicine 2009;180(12):1196-207.
2009: Anne Le; Rachel Zielinski; Chaoxia He; Michael T Crow; Shyam Biswal; Rubin M Tuder; Patrice M Becker
Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema.
American journal of respiratory and critical care medicine 2009;180(5):396-406.
2009: Norihiro Nagai; Rajesh K Thimmulappa; Marisol Cano; Masashi Fujihara; Kanako Izumi-Nagai; Xiaoni Kong; Michael B. Sporn; Thomas W Kensler; Shyam Biswal; James T Handa
Nrf2 is a critical modulator of the innate immune response in a model of uveitis.
Free radical biology & medicine 2009;47(3):300-6.
2009: Tirumalai Rangasamy; Vikas Misra; Lijie Zhen; Clarke G Tankersley; Rubin M Tuder; Shyam Biswal
Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression.
American journal of physiology. Lung cellular and molecular physiology 2009;296(6):L888-900.
2009: Steven S An; Jina Kim; Kwangmi Ahn; Xavier Trepat; Kenneth J Drake; SARVESH KUMAR; Guoyu Ling; Carolyn Purington; Tirumalai Rangasamy; Thomas W Kensler; Wayne Mitzner; Jeffrey J Fredberg; Shyam Biswal
Cell stiffness, contractile stress and the role of extracellular matrix.
Biochemical and biophysical research communications 2009;382(4):697-703.
2009: Sharon A McGrath-Morrow; Thomas Lauer; Min Yee; Enid R Neptune; Megan Podowski; Rajesh K Thimmulappa; Michael O'Reilly; Shyam Biswal
Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia.
American journal of physiology. Lung cellular and molecular physiology 2009;296(4):L565-73.
2009: C J Harvey; Rajesh K Thimmulappa; Anju Singh; D J Blake; G Ling; Nobunao Wakabayashi; J Fujii; Allen C Myers; Shyam Biswal
Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress.
Free radical biology & medicine 2009;46(4):443-53.
2009: Trinity J Bivalacqua; Thomas E Sussan; Melina A Gebska; Travis D Strong; Dan E Berkowitz; Shyam Biswal; Arthur L Burnett; Hunter C Champion
Sildenafil inhibits superoxide formation and prevents endothelial dysfunction in a mouse model of secondhand smoke induced erectile dysfunction.
The Journal of urology 2009;181(2):899-906.
2009: Anju Singh; Guoyu Ling; Avvaru N Suhasini; Pingwu Zhang; Masayuki Yamamoto; Ana Navas-Acien; Gregory Cosgrove; Rubin M Tuder; Thomas W Kensler; WALTER WATSON; Shyam Biswal
Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs.
Free radical biology & medicine 2009;46(3):376-86.
2009: Thomas E Sussan; Tirumalai Rangasamy; David J Blake; Deepti Malhotra; Hazim El-Haddad; Djahida Bedja; Melinda S Yates; Ponvijay Kombairaju; Masayuki Yamamoto; Karen T Liby; Michael B. Sporn; Kathleen L Gabrielson; Hunter C Champion; Rubin M Tuder; Thomas W Kensler; Shyam Biswal
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(1):250-5.
2008: Sofiyan Saleem; Hean Zhuang; Shyam Biswal; Yves Christen; Sylvain Dore
Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury.
Stroke; a journal of cerebral circulation 2008;39(12):3389-96.
2008: Anju Singh; Swetlana Boldin-Adamsky; Rajesh K Thimmulappa; Srikanta Kumar Rath; Hagit Ashush; Jonathan Coulter; Amanda Blackford; Steven Goodman; Fred Bunz; WALTER WATSON; Edward Gabrielson; Elena Feinstein; Shyam Biswal
RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy.
Cancer research 2008;68(19):7975-84.
2008: Marc A Williams; Tirumalai Rangasamy; Stephen M Bauer; Smruti Killedar; Matthew Karp; Thomas W Kensler; Masayuki Yamamoto; Patrick N Breysse; Shyam Biswal; Steve N Georas
Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):4545-59.
2008: Deepti Malhotra; Rajesh K Thimmulappa; Ana Navas-Acien; Andrew Sandford; Mark Elliott; Anju Singh; Linan Chen; Xiaoxi Zhuang; James Hogg; Peter Pare; Rubin M Tuder; Shyam Biswal
Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1.
American journal of respiratory and critical care medicine 2008;178(6):592-604.
2008: Rajesh K Thimmulappa; Tirumalai Rangasamy; Jawed Alam; Shyam Biswal
Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA adducts in lungs.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2008;4(5):473-81.
2008: Kewu Huang; Richard Rabold; Eric Abston; Brian Schofield; Vikas Misra; Ewa Galdzicka; Hannah Lee; Shyam Biswal; Wayne Mitzner; Clarke G Tankersley
Effects of leptin deficiency on postnatal lung development in mice.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;105(1):249-59.
2008: Kassim Traore; Rajni Sharma; Rajesh K Thimmulappa; WALTER WATSON; Shyam Biswal; Michael A Trush
Redox-regulation of Erk1/2-directed phosphatase by reactive oxygen species: role in signaling TPA-induced growth arrest in ML-1 cells.
Journal of cellular physiology 2008;216(1):276-85.
2008: An L Moens; Eiki Takimoto; Carlo G Tocchetti; Khalid Chakir; Djahida Bedja; Gianfranco Cormaci; Elizabeth A Ketner; Maulik Majmudar; Kathleen L Gabrielson; Marc K Halushka; James B Mitchell; Shyam Biswal; Keith M Channon; Michael S Wolin; Nicholas J Alp; Nazareno Paolocci; Hunter C Champion; David A Kass
Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy.
Circulation 2008;117(20):2626-36.
2008: Sharon A McGrath-Morrow; Tirumalai Rangasamy; Cecilia Cho; Thomas Sussan; Enid R Neptune; Robert Wise; Rubin M Tuder; Shyam Biswal
Impaired lung homeostasis in neonatal mice exposed to cigarette smoke.
American journal of respiratory cell and molecular biology 2008;38(4):393-400.
2008: Thomas E Sussan; Jonathan Jun; Rajesh K Thimmulappa; Djahida Bedja; Maria Antero; Kathleen L Gabrielson; Vsevolod Y Polotsky; Shyam Biswal
Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice.
PloS one 2008;3(11):e3791.
2008: Ronald C Taylor; George K Acquaah-Mensah; Mudita Singhal; Deepti Malhotra; Shyam Biswal
Network inference algorithms elucidate Nrf2 regulation of mouse lung oxidative stress.
PLoS computational biology 2008;4(8):e1000166.
2008: Masashi Fujihara; Norihiro Nagai; Thomas E Sussan; Shyam Biswal; James T Handa
Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice.
PloS one 2008;3(9):e3119.
2007: Narsa Reddy Machireddy; Steven R Kleeberger; Masayuki Yamamoto; Thomas W Kensler; Catherine Scollick; Shyam Biswal; SEKHAR POTHIREDDY
Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection.
Physiological genomics 2007;32(1):74-81.
2007: Srinivas Papaiahgari; Adi Yerrapureddy; Swetha R Reddy; Narsa Reddy Machireddy; Jeffrey M Dodd-o; Michael T Crow; Dmitry N Grigoryev; Kathleen C Barnes; Rubin M Tuder; Masayuki Yamamoto; Thomas W Kensler; Shyam Biswal; Wayne Mitzner; Paul M Hassoun; SEKHAR POTHIREDDY
Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice.
American journal of respiratory and critical care medicine 2007;176(12):1222-35.
2007: Vikas Misra; Hannah Lee; Anju Singh; Kewu Huang; Rajesh K Thimmulappa; Wayne Mitzner; Shyam Biswal; Clarke G Tankersley
Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes.
Physiological genomics 2007;31(3):429-40.
2007: Rajesh K Thimmulappa; RALPH FUCHS; Deepti Malhotra; Catherine Scollick; Kassim Traore; Jay H Bream; Michael A Trush; Karen T Liby; Michael B. Sporn; Thomas W Kensler; Shyam Biswal
Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.
Antioxidants & redox signaling 2007;9(11):1963-70.
2007: Shyam Biswal; Daniel G Remick
Sepsis: redox mechanisms and therapeutic opportunities.
Antioxidants & redox signaling 2007;9(11):1959-61.
2007: Soona Shin; Nobunao Wakabayashi; Vikas Misra; Shyam Biswal; Gum Hwa Lee; Elin Agoston; Masayuki Yamamoto; Thomas W Kensler
NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis.
Molecular and cellular biology 2007;27(20):7188-97.
2007: Jian Wang; Jocelyn Fields; Chunying Zhao; John Langer; Rajesh K Thimmulappa; Thomas W Kensler; Masayuki Yamamoto; Shyam Biswal; Sylvain Dore
Role of Nrf2 in protection against intracerebral hemorrhage injury in mice.
Free radical biology & medicine 2007;43(3):408-14.
2007: Narsa Reddy Machireddy; Steven R Kleeberger; Hye-Youn Cho; Masayuki Yamamoto; Thomas W Kensler; Shyam Biswal; SEKHAR POTHIREDDY
Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants.
American journal of respiratory cell and molecular biology 2007;37(1):3-8.
2007: Zahoor Shah; Rung-chi Li; Rajesh K Thimmulappa; Thomas W Kensler; Masayuki Yamamoto; Shyam Biswal; Sylvain Dore
Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury.
Neuroscience 2007;147(1):53-9.
2007: Samuel J Rulli; Catherine S Hibbert; Jane Mirro; Thoru Pederson; Shyam Biswal; Alan Rein
Selective and nonselective packaging of cellular RNAs in retrovirus particles.
Journal of virology 2007;81(12):6623-31.
2007: Shyam Biswal
Erratum: figure.
American journal of respiratory cell and molecular biology 2007;36(5):642.
2007: Kewu Huang; Wayne Mitzner; Richard Rabold; Brian Schofield; Hannah Lee; Shyam Biswal; Clarke G Tankersley
Variation in senescent-dependent lung changes in inbred mouse strains.
Journal of applied physiology (Bethesda, Md. : 1985) 2007;102(4):1632-9.
2007: Alexander Balbir; Hannah Lee; Mariko Okumura; Shyam Biswal; Robert S Fitzgerald; Machiko Shirahata
A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice.
American journal of physiology. Lung cellular and molecular physiology 2007;292(3):L704-15.
2007: Thomas W Kensler; Nobunao Wakabayashi; Shyam Biswal
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.
Annual review of pharmacology and toxicology 2007;47():89-116.
2006: Rajesh K Thimmulappa; Catherine Scollick; Kassim Traore; Melinda Yates; Michael A Trush; Karen T Liby; Michael B. Sporn; Masayuki Yamamoto; Thomas W Kensler; Shyam Biswal
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide.
Biochemical and biophysical research communications 2006;351(4):883-9.
2006: Anju Singh; Tirumalai Rangasamy; Rajesh K Thimmulappa; Hannah Lee; William O Osburn; Regina Brigelius-Flohé; Thomas W Kensler; Masayuki Yamamoto; Shyam Biswal
Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2.
American journal of respiratory cell and molecular biology 2006;35(6):639-50.
2006: Rubin M Tuder; Toshinori Yoshida; Iwona Fijalkowka; Shyam Biswal; Irina Petrache
Role of lung maintenance program in the heterogeneity of lung destruction in emphysema.
Proceedings of the American Thoracic Society 2006;3(8):673-9.
2006: Anju Singh; Vikas Misra; Rajesh K Thimmulappa; Hannah Lee; Stephen Ames; Mohammad Hoque; James G Herman; Stephen B Baylin; David Sidransky; Edward Gabrielson; Malcolm V Brock; Shyam Biswal
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer.
PLoS medicine 2006;3(10):e420.
2006: William O Osburn; Nobunao Wakabayashi; Vikas Misra; Tricia Nilles; Shyam Biswal; Michael A Trush; Thomas W Kensler
Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion.
Archives of biochemistry and biophysics 2006;454(1):7-15.
2006: Sunil K Manna; Thirumalai Rangasamy; Kimberly Wise; Shubhashish Sarkar; Shishir Shishodia; Shyam Biswal; Govindarajan T Ramesh
Long term environmental tobacco smoke activates nuclear transcription factor-kappa B, activator protein-1, and stress responsive kinases in mouse brain.
Biochemical pharmacology 2006;71(11):1602-9.
2006: Rajesh K Thimmulappa; Hannah Lee; Tirumalai Rangasamy; SEKHAR POTHIREDDY; Masayuki Yamamoto; Thomas W Kensler; Shyam Biswal
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.
The Journal of clinical investigation 2006;116(4):984-95.
2006: B Do; C Mari; Shyam Biswal; J Kalinyak; A Quon; S S Gambhir
Diagnosis of aseptic deep venous thrombosis of the upper extremity in a cancer patient using fluorine-18 fluorodeoxyglucose positron emission tomography/computerized tomography (FDG PET/CT).
Annals of nuclear medicine 2006;20(2):151-5.
2006: George K Acquaah-Mensah; Vikas Misra; Shyam Biswal
Ethanol sensitivity: a central role for CREB transcription regulation in the cerebellum.
BMC genomics 2006;7():308.
2005: Jane Tian; Kazuki Ishibashi; Kazuko Ishibashi; Karen M Reiser; Rhonda Grebe; Shyam Biswal; Peter L Gehlbach; James T Handa
Advanced glycation endproduct-induced aging of the retinal pigment epithelium and choroid: a comprehensive transcriptional response.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(33):11846-51.
2005: Tirumalai Rangasamy; Jia Guo; Wayne Mitzner; Jesse Roman; Anju Singh; Allison Fryer; Masayuki Yamamoto; Thomas W Kensler; Rubin M Tuder; Steve N Georas; Shyam Biswal
Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice.
The Journal of experimental medicine 2005;202(1):47-59.
2005: Hexin Chen; Ethel Rubin; Huiping Zhang; Seung Chung; Chunfa Jie; Elizabeth Garrett-Mayer; Shyam Biswal; Saraswati Sukumar
Identification of transcriptional targets of HOXA5.
The Journal of biological chemistry 2005;280(19):19373-80.
2005: Rafael A Irizarry; Daniel S Warren; Forrest Spencer; Irene F Kim; Shyam Biswal; Bryan C Frank; Edward Gabrielson; Joe G. N. Garcia; Joel Geoghegan; Gregory G Germino; Constance A Griffin; Sara C Hilmer; Eric Hoffman; Anne E Jedlicka; Ernest Kawasaki; Francisco Martínez-Murillo; Laura Morsberger; Hannah Lee; David Petersen; John Quackenbush; Alan L Scott; Michael Wilson; Yanqin Yang; Shui Q Ye; Wayne Yu
Multiple-laboratory comparison of microarray platforms.
Nature methods 2005;2(5):345-50.
2004: Tirumalai Rangasamy; Chung Y Cho; Rajesh K Thimmulappa; Lijie Zhen; Sorachai Srisuma; Thomas W Kensler; Masayuki Yamamoto; Irina Petrache; Rubin M Tuder; Shyam Biswal
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice.
The Journal of clinical investigation 2004;114(9):1248-59.
2003: Shyam Biswal; Terrie Maxwell; Tirumalai Rangasamy; James P Kehrer
Modulation of benzo[a]pyrene-induced p53 DNA activity by acrolein.
Carcinogenesis 2003;24(8):1401-6.
2003: Sorachai Srisuma; Shyam Biswal; Wayne Mitzner; Sandra J Gallagher; Kim H Mai; Elizabeth M Wagner
Identification of genes promoting angiogenesis in mouse lung by transcriptional profiling.
American journal of respiratory cell and molecular biology 2003;29(2):172-9.
2003: Xuli Wu; Shyam Biswal; James P Kehrer
Roles of 5-lipoxygenase activating protein in cell proliferation and apoptosis.
Cell biology and toxicology 2003;19(3):135-43.
2002: Rajesh K Thimmulappa; Kim H Mai; Sorachai Srisuma; Thomas W Kensler; Masayuki Yamamoto; Shyam Biswal
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.
Cancer research 2002;62(18):5196-203.
2002: R Tirumalai; T Rajesh Kumar; Kim H Mai; Shyam Biswal
Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells.
Toxicology letters 2002;132(1):27-36.
2002: Shyam Biswal; George K Acquaah-Mensah; Kaushik Datta; Xuli Wu; James P Kehrer
Inhibition of cell proliferation and AP-1 activity by acrolein in human A549 lung adenocarcinoma cells due to thiol imbalance and covalent modifications.
Chemical research in toxicology 2002;15(2):180-6.
2001: K Datta; Julie C Kern; Shyam Biswal; James P Kehrer
Proteolytic loss of bcl-x(L) in FL5.12 Cells undergoing apoptosis induced by MK886.
Toxicology and applied pharmacology 2001;174(3):273-81.
2001: James P Kehrer; Shyam Biswal; Eunhye La; Philippe Thuillier; K Datta; Susan M Fischer; J P Vanden Heuvel
Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886.
The Biochemical journal 2001;356(Pt 3):899-906.
2001: Shyam Biswal; K Datta; James P Kehrer
Association between bcl-x(L) and 5-lipoxygenase activating protein (FLAP) levels in IL-3-dependent FL5.12 cells.
Toxicology 2001;160(1-3):97-103.
2000: Shyam Biswal; K Datta; George K Acquaah-Mensah; James P Kehrer
Changes in ceramide and sphingomyelin following fludarabine treatment of human chronic B-cell leukemia cells.
Toxicology 2000;154(1-3):45-53.
2000: James P Kehrer; Shyam Biswal
The molecular effects of acrolein.
Toxicological sciences : an official journal of the Society of Toxicology 2000;57(1):6-15.
2000: Shyam Biswal; K Datta; S D Shaw; X Feng; JD Robertson; James P Kehrer
Glutathione oxidation and mitochondrial depolarization as mechanisms of nordihydroguaiaretic acid-induced apoptosis in lipoxygenase-deficient FL5.12 cells.
Toxicological sciences : an official journal of the Society of Toxicology 2000;53(1):77-83.
1999: JD Robertson; K Datta; Shyam Biswal; James P Kehrer
Heat-shock protein 70 antisense oligomers enhance proteasome inhibitor-induced apoptosis.
The Biochemical journal 1999;344 Pt 2():477-85.
1999: K Datta; Shyam Biswal; James P Kehrer
The 5-lipoxygenase-activating protein (FLAP) inhibitor, MK886, induces apoptosis independently of FLAP.
The Biochemical journal 1999;340 ( Pt 2)():371-5.
1999: ND Horton; Shyam Biswal; L L Corrigan; J Bratta; James P Kehrer
Acrolein causes inhibitor kappaB-independent decreases in nuclear factor kappaB activation in human lung adenocarcinoma (A549) cells.
The Journal of biological chemistry 1999;274(14):9200-6.
1998: K Datta; Shyam Biswal; Jing Xu; Kelly M Towndrow; X Feng; James P Kehrer
A relationship between 5-lipoxygenase-activating protein and bcl-xL expression in murine pro-B lymphocytic FL5.12 cells.
The Journal of biological chemistry 1998;273(43):28163-9.
1997: YT Ahn; X L Wu; Shyam Biswal; Soundarapandian Velmurugan; F C Volkert; Makkuni Jayaram
The 2microm-plasmid-encoded Rep1 and Rep2 proteins interact with each other and colocalize to the Saccharomyces cerevisiae nucleus.
Journal of bacteriology 1997;179(23):7497-506.
1993: N Nath; S Biswas; A Bhelwa; A Ittoop; Shyam Biswal
Plausible involvement of a diabetic serum factor in neutrophil membrane pathology.
Indian journal of biochemistry & biophysics 1993;30(4):244-6.