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Helton Santiago

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Bin Zhan; Jeffrey Bethony; L M de Oliveira; David J Diemert; X Feng; P Gillespie; P J Hotez; D Jiang; K Jones; B Keegan; Helton C Santiago; S-H Xiao; J Xue; Maria Elena Bottazzi
Fusion of Na-ASP-2 with human immunoglobulin Fcγ abrogates histamine release from basophils sensitized with anti-Na-ASP-2 IgE.
Helton C Santiago; Joseph Urban; Mark Wilson; Thomas Wynn; Sasisekhar Bennuru; David Garboczi; Elyse LeeVan; Edward Mitre; Ellen Mueller; Flavia Ribeiro-Gomes; Thomas B Nutman
Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization.
Helton C Santiago; Wagner L Tafuri; Mauro M Teixeira; Lara Utsch; Rosana O Alves; José C F Alves-Filho; Maria José Campagnole-Santos; Fernando Queiroz Cunha; Claudia Z Gonzalez Lombana; Juan P Macedo; Rafael Radi; Alvaro J Romanha; Leda Q Vieira
NADPH phagocyte oxidase knockout mice control Trypanosoma cruzi proliferation, but develop circulatory collapse and succumb to infection.

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All Publications

2012: Bin Zhan; Jeffrey Bethony; L M de Oliveira; David J Diemert; X Feng; P Gillespie; P J Hotez; D Jiang; K Jones; B Keegan; Helton C Santiago; S-H Xiao; J Xue; Maria Elena Bottazzi
Fusion of Na-ASP-2 with human immunoglobulin Fcγ abrogates histamine release from basophils sensitized with anti-Na-ASP-2 IgE.
Parasite immunology 2012;34(8-9):404-11.
2012: Helton C Santiago; Joseph Urban; Mark Wilson; Thomas Wynn; Sasisekhar Bennuru; David Garboczi; Elyse LeeVan; Edward Mitre; Ellen Mueller; Flavia Ribeiro-Gomes; Thomas B Nutman
Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization.
The Journal of allergy and clinical immunology 2012;130(1):248-56.e9.
2012: Helton C Santiago; Wagner L Tafuri; Mauro M Teixeira; Lara Utsch; Rosana O Alves; José C F Alves-Filho; Maria José Campagnole-Santos; Fernando Queiroz Cunha; Claudia Z Gonzalez Lombana; Juan P Macedo; Rafael Radi; Alvaro J Romanha; Leda Q Vieira
NADPH phagocyte oxidase knockout mice control Trypanosoma cruzi proliferation, but develop circulatory collapse and succumb to infection.
PLoS neglected tropical diseases 2012;6(2):e1492.
2011: Helton C Santiago; Sasisekhar Bennuru; Alexis Boyd; Mark Eberhard; Thomas B Nutman
Structural and immunologic cross-reactivity among filarial and mite tropomyosin: implications for the hygiene hypothesis.
The Journal of allergy and clinical immunology 2011;127(2):479-86.
2011: T U Maioli; F A Assis; P M A Vieira; P Borelli; Helton C Santiago; R Alves; Alvaro J Romanha; Cláudia Martins Carneiro; A M C Faria
Splenectomy increases mortality in murine Trypanosoma cruzi infection.
Scandinavian journal of immunology 2011;73(1):36-45.
2010: Ester Roffê; Fabiano Oliveira; Adriano L S Souza; Vanessa Pinho; Danielle G Souza; Patrícia R S Souza; Remo C Russo; Helton C Santiago; Alvaro J Romanha; Herbert B Tanowitz; Jesus G Valenzuela; Mauro M Teixeira
Role of CCL3/MIP-1alpha and CCL5/RANTES during acute Trypanosoma cruzi infection in rats.
Microbes and infection / Institut Pasteur 2010;12(8-9):669-76.
2010: Rodrigo Guabiraba; Ana Lucia Campanha-Rodrigues; Adriano L S Souza; Helton C Santiago; Lugnier Claire; Jacqueline Alvarez-Leite; Virgínia S Lemos; Mauro M Teixeira
The flavonoid dioclein reduces the production of pro-inflammatory mediators in vitro by inhibiting PDE4 activity and scavenging reactive oxygen species.
European journal of pharmacology 2010;633(1-3):85-92.
2009: Ricardo T Fujiwara; Guilherme G L Cançado; Paula A Freitas; Helton C Santiago; Cristiano Lara Massara; Omar Dos Santos Carvalho; Rodrigo Corrêa-Oliveira; Stefan M Geiger; Jeffrey Bethony
Necator americanus infection: a possible cause of altered dendritic cell differentiation and eosinophil profile in chronically infected individuals.
PLoS neglected tropical diseases 2009;3(3):e399.
2008: C Z González-Lombana; Helton C Santiago; J P Macedo; V A R Seixas; Remo C Russo; Washington Luiz Tafuri; Luis Afonso; Leda Q Vieira
Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth.
Acta tropica 2008;106(1):27-38.
2008: Luciane R Portugal; Luciana R Fernandes; Vinícius S Pietra Pedroso; Helton C Santiago; Ricardo T Gazzinelli; Jacqueline I Alvarez-Leite
Influence of low-density lipoprotein (LDL) receptor on lipid composition, inflammation and parasitism during Toxoplasma gondii infection.
Microbes and infection / Institut Pasteur 2008;10(3):276-84.
2007: sulay moreno; Carl G Feng; Helton C Santiago; Julio Aliberti; Allen W Cheever; Karen E Thomas; Gregory A Taylor; Stefanie N Vogel; Alan Sher
The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(8):5514-22.
2007: Andrea A Silva; Ester Roffê; Helton C Santiago; Ana Paula M P Marino; Karina Kroll-Palhares; Mauro Teixeira; Ricardo T Gazzinelli; Joseli Lannes-Vieira
Trypanosoma cruzi-triggered meningoencephalitis is a CCR1/CCR5-independent inflammatory process.
Journal of neuroimmunology 2007;184(1-2):156-63.
2006: Ester Roffê; Adriano L S Souza; Bráulia C Caetano; Patrícia P Machado; Lucíola S Barcelos; Remo C Russo; Helton C Santiago; Danielle G Souza; Vanessa Pinho; Herbert B Tanowitz; Elizabeth R S Camargos; Oscar Bruña-Romero; Mauro Teixeira
A DNA vaccine encoding CCL4/MIP-1beta enhances myocarditis in experimental Trypanosoma cruzi infection in rats.
Microbes and infection / Institut Pasteur 2006;8(12-13):2745-55.
2006: sulay moreno; Helton C Santiago; Romina S Goldszmid; Catherine Ropert; Ricardo T Gazzinelli; Alan Sher
Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(6):3515-9.
2006: Helton C Santiago; Maíra Faria Braga Pires; Danielle G Souza; Ester Roffê; Denise F Côrtes; Washington Luiz Tafuri; Mauro Teixeira; Leda Q Vieira
Platelet activating factor receptor-deficient mice present delayed interferon-gamma upregulation and high susceptibility to Leishmania amazonensis infection.
Microbes and infection / Institut Pasteur 2006;8(11):2569-77.
2005: Helton C Santiago; Carl G Feng; sulay moreno; Ester Roffe; Rosa M E Arantes; Allen W Cheever; Gregory Taylor; Leda Q Vieira; Leda Q Vierira; Julio Aliberti; Ricardo T Gazzinelli; Alan Sher
Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):8165-72.
2004: Helton C Santiago; Carolina Ferreira Oliveira; Luciana Santiago; Fernanda Oliveira Ferraz; Daniele da Glória de Souza; Luiz A R De Freitas; Luis Afonso; Mauro Teixeira; Ricardo T Gazzinelli; Leda Q Vieira
Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania major.
Infection and immunity 2004;72(8):4918-23.
2004: Luciane R Portugal; Luciana R Fernandes; Giovana C Cesar; Helton C Santiago; Dirce R Oliveira; Neide M Silva; Andrea A Silva; Joseli Lannes-Vieira; Rosa M E Arantes; Ricardo T Gazzinelli; Jacqueline I Alvarez-Leite
Infection with Toxoplasma gondii increases atherosclerotic lesion in ApoE-deficient mice.
Infection and immunity 2004;72(6):3571-6.
2003: Maria C G Peluzio; Emir Miguel; Thaís C Drumond; Giovana C César; Helton C Santiago; Mauro Teixeira; Enio C Vieira; Rosa M E Arantes; Jacqueline I Alvarez-Leite
Monocyte chemoattractant protein-1 involvement in the alpha-tocopherol-induced reduction of atherosclerotic lesions in apolipoprotein E knockout mice.
The British journal of nutrition 2003;90(1):3-11.
2001: Paula V A dos Santos; Ester Roffê; Helton C Santiago; R A Torres; Ana Paula M P Marino; Cláudia N Paiva; Andrea A Silva; Ricardo T Gazzinelli; Joseli Lannes-Vieira
Prevalence of CD8(+)alpha beta T cells in Trypanosoma cruzi-elicited myocarditis is associated with acquisition of CD62L(Low)LFA-1(High)VLA-4(High) activation phenotype and expression of IFN-gamma-inducible adhesion and chemoattractant molecules.
Microbes and infection / Institut Pasteur 2001;3(12):971-84.
2001: Ana Paula Fernandes; Fernando Aécio Amorim Carvalho; Carlos Alberto Pereira Tavares; Helton C Santiago; G A Castro; Washington Luiz Tafuri; Lucas A M Ferreira; Ricardo T Gazzinelli
Combined interleukin-12 and topical chemotherapy for established Leishmaniasis drastically reduces tissue parasitism and relapses in susceptible mice.
The Journal of infectious diseases 2001;183(11):1646-52.
2000: M A P Oliveira; Helton C Santiago; C R Lisboa; I P Ceravollo; Trinchieri Giorgio; Ricardo T Gazzinelli; Leda Q Vieira
Leishmania sp: comparative study with Toxoplasma gondii and Trypanosoma cruzi in their ability to initialize IL-12 and IFN-gamma synthesis.
Experimental parasitology 2000;95(2):96-105.
1999: Helton C Santiago; M A P Oliveira; Eduardo A Bambirra; A M Faria; Luis Afonso; Leda Q Vieira; Ricardo T Gazzinelli
Coinfection with Toxoplasma gondii inhibits antigen-specific Th2 immune responses, tissue inflammation, and parasitism in BALB/c mice infected with Leishmania major.
Infection and immunity 1999;67(9):4939-44.
1998: Ricardo T Gazzinelli; Andre Talvani; Maristela Martins de Camargo; Helton C Santiago; M A P Oliveira; Leda Q Vieira; Gislaine Martins; Julio Aliberti; João S Silva
Induction of cell-mediated immunity during early stages of infection with intracellular protozoa.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1998;31(1):89-104.