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Pilar Santisteban

Research Profile

Anatomy

Living Beings

Rats

Chemicals & Drugs

Physiology

Disorders

Thyroid Neoplasms

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Publications

TOP 3
Lara P Fernández; Gonzalo Gómez-López; Arístides López-Márquez; Angel M Martínez; Pilar Santisteban
New Insights into FoxE1 Functions: Identification of Direct FoxE1 Targets in Thyroid Cells.
Miguel A Zaballos; Pilar Santisteban
FOXO1 controls thyroid cell proliferation in response to TSH and IGF-I and is involved in thyroid tumorigenesis.
Ana Chocarro-Calvo; Pilar Santisteban; Miguel A Zaballos; Custodia García-Jiménez
DARPP-32 is required for MAPK/ERK signaling in thyroid cells.

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All Publications

2013: Lara P Fernández; Gonzalo Gómez-López; Arístides López-Márquez; Angel M Martínez; Pilar Santisteban
New Insights into FoxE1 Functions: Identification of Direct FoxE1 Targets in Thyroid Cells.
PloS one 2013;8(5):e62849.
2013: Miguel A Zaballos; Pilar Santisteban
FOXO1 controls thyroid cell proliferation in response to TSH and IGF-I and is involved in thyroid tumorigenesis.
Molecular endocrinology (Baltimore, Md.) 2013;27(1):50-62.
2012: Ana Chocarro-Calvo; Pilar Santisteban; Miguel A Zaballos; Custodia García-Jiménez
DARPP-32 is required for MAPK/ERK signaling in thyroid cells.
Molecular endocrinology (Baltimore, Md.) 2012;26(3):471-80.
2012: Ana Sastre-Perona; Pilar Santisteban
Role of the wnt pathway in thyroid cancer.
Frontiers in endocrinology 2012;3():31.
2012: Sergio Ruiz-Llorente; Ana Sastre-Perona; Alfonso Valencia; Enrique Carrillo Santa de Pau; James A Fagin; Gonzalo Gómez-López; Cristina Montero-Conde; David Pisano; Pilar Santisteban
Genome-wide analysis of Pax8 binding provides new insights into thyroid functions.
BMC genomics 2012;13():147.
2011: Suzana G Leoni; Pilar Santisteban; Edna T Kimura; Antonio De la Vieja
Regulation of thyroid oxidative state by thioredoxin reductase has a crucial role in thyroid responses to iodide excess.
Molecular endocrinology (Baltimore, Md.) 2011;25(11):1924-35.
2011: Garcilaso Riesco-Eizaguirre; Irene Rodríguez; Antonio De la Vieja; Pilar Martín-Duque; Soledad Miranda; Georges VASSAUX; Pilar Santisteban
Telomerase-driven expression of the sodium iodide symporter (NIS) for in vivo radioiodide treatment of cancer: a new broad-spectrum NIS-mediated antitumor approach.
The Journal of clinical endocrinology and metabolism 2011;96(9):E1435-43.
2010: Pilar Santisteban; Pablo Recacha; David E Metzger; Kenneth S Zaret
Dynamic expression of Groucho-related genes Grg1 and Grg3 in foregut endoderm and antagonism of differentiation.
Developmental dynamics : an official publication of the American Association of Anatomists 2010;239(3):980-6.
2009: Garcilaso Riesco-Eizaguirre; Irene Rodríguez; Antonio De la Vieja; Eugenia Costamagna; Nancy Carrasco; Manuel Nistal; Pilar Santisteban
The BRAFV600E oncogene induces transforming growth factor beta secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer.
Cancer research 2009;69(21):8317-25.
2008: Miguel A Zaballos; Bibian Garcia; Pilar Santisteban
Gbetagamma dimers released in response to thyrotropin activate phosphoinositide 3-kinase and regulate gene expression in thyroid cells.
Molecular endocrinology (Baltimore, Md.) 2008;22(5):1183-99.
2007: Garcilaso Riesco-Eizaguirre; Pilar Santisteban
New insights in thyroid follicular cell biology and its impact in thyroid cancer therapy.
Endocrine-related cancer 2007;14(4):957-77.
2007: G Riesco-Eizaguirre; Pilar Santisteban
Molecular biology of thyroid cancer initiation.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2007;9(11):686-93.
2007: Sergio Ruiz-Llorente; Cristina Montero-Conde; Roger L Milne; Christian M Moya; Arancha Cebrián; Rocío Letón; Alberto Cascón; Fátima Mercadillo; Iñigo Landa; Salud Borrego; Guiomar Pérez de Nanclares; Cristina Alvarez-Escolá; José Angel Díaz-Pérez; Angel Carracedo; Miguel Urioste; Anna González-Neira; Javier Benítez; Pilar Santisteban; Joaquín Dopazo; Bruce A J Ponder; Mercedes Robledo
Association study of 69 genes in the ret pathway identifies low-penetrance loci in sporadic medullary thyroid carcinoma.
Cancer research 2007;67(19):9561-7.
2007: Isabel Cuesta; Kenneth S Zaret; Pilar Santisteban
The forkhead factor FoxE1 binds to the thyroperoxidase promoter during thyroid cell differentiation and modifies compacted chromatin structure.
Molecular and cellular biology 2007;27(20):7302-14.
2007: Custodia García-Jiménez; Pilar Santisteban
TSH signalling and cancer.
Arquivos brasileiros de endocrinologia e metabologia 2007;51(5):654-71.
2006: Garcilaso Riesco-Eizaguirre; Pilar Santisteban
A perspective view of sodium iodide symporter research and its clinical implications.
European journal of endocrinology / European Federation of Endocrine Societies 2006;155(4):495-512.
2006: María L Vélez; Eugenia Costamagna; Edna T Kimura; Laura Fozzatti; Claudia G Pellizas; María M Montesinos; Ariel M Lucero; Aldo H Coleoni; Pilar Santisteban; Ana M Masini-Repiso
Bacterial lipopolysaccharide stimulates the thyrotropin-dependent thyroglobulin gene expression at the transcriptional level by involving the transcription factors thyroid transcription factor-1 and paired box domain transcription factor 8.
Endocrinology 2006;147(7):3260-75.
2006: Christian M Moya; Guiomar Perez de Nanclares; Luis Castaño; Neus Potau; J Ramón Bilbao; Antonio Carrascosa; María Bargadá; Raquel Coya; Pedro Martul; Enric Vicens-Calvet; Pilar Santisteban
Functional study of a novel single deletion in the TITF1/NKX2.1 homeobox gene that produces congenital hypothyroidism and benign chorea but not pulmonary distress.
The Journal of clinical endocrinology and metabolism 2006;91(5):1832-41.
2006: G Riesco-Eizaguirre; P Gutiérrez-Martínez; Miguel Angel García-Cabezas; Manuel Nistal; Pilar Santisteban
The oncogene BRAF V600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I- targeting to the membrane.
Endocrine-related cancer 2006;13(1):257-69.
2005: Custodia García-Jiménez; Miguel A Zaballos; Pilar Santisteban
DARPP-32 (dopamine and 3',5'-cyclic adenosine monophosphate-regulated neuronal phosphoprotein) is essential for the maintenance of thyroid differentiation.
Molecular endocrinology (Baltimore, Md.) 2005;19(12):3060-72.
2005: Pilar Santisteban; Juan Bernal
Thyroid development and effect on the nervous system.
Reviews in endocrine & metabolic disorders 2005;6(3):217-28.
2004: Marcos Rivas; Britt Mellström; Jose R Naranjo; Pilar Santisteban
Transcriptional repressor DREAM interacts with thyroid transcription factor-1 and regulates thyroglobulin gene expression.
The Journal of biological chemistry 2004;279(32):33114-22.
2004: Anna Novials; E Mato; M Lucas; C Franco; M Rivas; Pilar Santisteban; Ramon Gomis
Mutation at position -132 in the islet amyloid polypeptide ( IAPP) gene promoter enhances basal transcriptional activity through a new CRE-like binding site.
Diabetologia 2004;47(7):1167-74.
2004: Eugenia Costamagna; Bibian García; Pilar Santisteban
The functional interaction between the paired domain transcription factor Pax8 and Smad3 is involved in transforming growth factor-beta repression of the sodium/iodide symporter gene.
The Journal of biological chemistry 2004;279(5):3439-46.
2004: Pierfrancesco Vargiu; Ricardo De Abajo; Juan Antonio Garcia-Ranea; Alfonso Valencia; Pilar Santisteban; Piero Crespo; Juan Bernal
The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors.
Oncogene 2004;23(2):559-68.
2003: Marcos Rivas; Pilar Santisteban
TSH-activated signaling pathways in thyroid tumorigenesis.
Molecular and cellular endocrinology 2003;213(1):31-45.
2002: Bibian García; Pilar Santisteban
PI3K is involved in the IGF-I inhibition of TSH-induced sodium/iodide symporter gene expression.
Molecular endocrinology (Baltimore, Md.) 2002;16(2):342-52.
2002: Diego L Medina; Marcos Rivas; Patricia Cruz; Isabel Barroso; Javier Regadera; Pilar Santisteban
RhoA activation promotes transformation and loss of thyroid cell differentiation interfering with thyroid transcription factor-1 activity.
Molecular endocrinology (Baltimore, Md.) 2002;16(1):33-44.
2000: Diego L Medina; Pilar Santisteban
Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems.
European journal of endocrinology / European Federation of Endocrine Societies 2000;143(2):161-78.
2000: A Losada; Juan A Tovar; H M Xia; Juan A Diez-Pardo; Pilar Santisteban
Down-regulation of thyroid transcription factor-1 gene expression in fetal lung hypoplasia is restored by glucocorticoids.
Endocrinology 2000;141(6):2166-73.
2000: Diego L Medina; M J Toro; Pilar Santisteban
Somatostatin interferes with thyrotropin-induced G1-S transition mediated by cAMP-dependent protein kinase and phosphatidylinositol 3-kinase. Involvement of RhoA and cyclin E x cyclin-dependent kinase 2 complexes.
The Journal of biological chemistry 2000;275(20):15549-56.
2000: Diego L Medina; Koichi Suzuki; M Pietrarelli; F Okajima; Leonard D Kohn; Pilar Santisteban
Role of insulin and serum on thyrotropin regulation of thyroid transcription factor-1 and pax-8 genes expression in FRTL-5 thyroid cells.
Thyroid : official journal of the American Thyroid Association 2000;10(4):295-303.
2000: Tatiana Dilla; Juan A Velasco; Diego L Medina; J F González-Palacios; Pilar Santisteban
The MDM2 oncoprotein promotes apoptosis in p53-deficient human medullary thyroid carcinoma cells.
Endocrinology 2000;141(1):420-9.
1999: A I Loaiza-Pérez; M T Seisdedos; Diana L Kleiman de Pisarev; Horacio A Sancovich; Andrea S Randi; Ana M Ferramola de Sancovich; Pilar Santisteban
Hexachlorobenzene, a dioxin-type compound, increases malic enzyme gene transcription through a mechanism involving the thyroid hormone response element.
Endocrinology 1999;140(9):4142-51.
1999: Isabel Barroso; B Benito; C Garcí-Jiménez; Arturo Hernández; Maria Jesus Obregón; Pilar Santisteban
Norepinephrine, tri-iodothyronine and insulin upregulate glyceraldehyde-3-phosphate dehydrogenase mRNA during Brown adipocyte differentiation.
European journal of endocrinology / European Federation of Endocrine Societies 1999;141(2):169-79.
1999: Isabel Barroso; Pilar Santisteban
Insulin-induced early growth response gene (Egr-1) mediates a short term repression of rat malic enzyme gene transcription.
The Journal of biological chemistry 1999;274(25):17997-8004.
1999: L Ortiz; P Aza-Blanc; Mariastella Zannini; Andrew C B Cato; Pilar Santisteban
The interaction between the forkhead thyroid transcription factor TTF-2 and the constitutive factor CTF/NF-1 is required for efficient hormonal regulation of the thyroperoxidase gene transcription.
The Journal of biological chemistry 1999;274(21):15213-21.
1999: P Ros; D L Rossi; A Acebrón; Pilar Santisteban
Thyroid-specific gene expression in the multi-step process of thyroid carcinogenesis.
Biochimie 1999;81(4):389-96.
1999: A Losada; H Xia; L Migliazza; Juan A Diez-Pardo; Pilar Santisteban; Juan A Tovar
Lung hypoplasia caused by nitrofen is mediated by down-regulation of thyroid transcription factor TTF-1.
Pediatric surgery international 1999;15(3-4):188-91.
1999: Diego L Medina; Juan A Velasco; Pilar Santisteban
Somatostatin is expressed in FRTL-5 thyroid cells and prevents thyrotropin-mediated down-regulation of the cyclin-dependent kinase inhibitor p27kip1.
Endocrinology 1999;140(1):87-95.
1998: Juan A Velasco; A Acebrón; Mariastella Zannini; Jorge Martín-Pérez; Roberto Di Lauro; Pilar Santisteban
Ha-ras interference with thyroid cell differentiation is associated with a down-regulation of thyroid transcription factor-1 phosphorylation.
Endocrinology 1998;139(6):2796-802.
1998: Fátima Cruz; S R Scott; Isabel Barroso; Pilar Santisteban; Sebastián Cerdán
Ontogeny and cellular localization of the pyruvate recycling system in rat brain.
Journal of neurochemistry 1998;70(6):2613-9.
1998: A I Loaiza Perez; Horacio A Sancovich; Diana L Kleiman de Pisarev; Andrea S Randi; M Seisdedos; Ana M Ferramola de Sancovich; Pilar Santisteban
[Effect of thyroid hormones on the modulation of genetic expression of liver cytosolic malic enzyme, in rats poisoned with hexachlorobenzene].
Acta physiologica, pharmacologica et therapeutica latinoamericana : órgano de la Asociación Latinoamericana de Ciencias Fisiológicas y [de] la Asociación Latinoamericana de Farmacología 1998;48(3):125-36.
1997: Juan A Velasco; Diego L Medina; J Romero; M E Mato; Pilar Santisteban
Introduction of p53 induces cell-cycle arrest in p53-deficient human medullary-thyroid-carcinoma cells.
International journal of cancer. Journal international du cancer 1997;73(3):449-55.
1997: E Mato; Pilar Santisteban; J A Chowen; O Fornas; M Bouwens; M Puig-Domingo; J Argente; S M Webb
Circannual somatostatin gene and somatostatin receptor gene expression in the early post-natal rat pineal gland.
Neuroendocrinology 1997;66(5):368-74.
1997: L Ortiz; Mariastella Zannini; Roberto Di Lauro; Pilar Santisteban
Transcriptional control of the forkhead thyroid transcription factor TTF-2 by thyrotropin, insulin, and insulin-like growth factor I.
The Journal of biological chemistry 1997;272(37):23334-9.
1997: A de la Vieja; Miguel Calero; Pilar Santisteban; L Lamas
Identification and quantitation of iodotyrosines and iodothyronines in proteins using high-performance liquid chromatography by photodiode-array ultraviolet-visible detection.
Journal of chromatography. B, Biomedical sciences and applications 1997;688(1):143-9.
1996: Mariastella Zannini; A Acebron; M De Felice; M I Arnone; J Martin-Pérez; Pilar Santisteban; Roberto Di Lauro
Mapping and functional role of phosphorylation sites in the thyroid transcription factor-1 (TTF-1).
The Journal of biological chemistry 1996;271(4):2249-54.
1995: D L Rossi; A Acebrón; Pilar Santisteban
Function of the homeo and paired domain proteins TTF-1 and Pax-8 in thyroid cell proliferation.
The Journal of biological chemistry 1995;270(39):23139-42.
1995: A Acebrón; P Aza-Blanc; D L Rossi; L Lamas; Pilar Santisteban
Congenital human thyroglobulin defect due to low expression of the thyroid-specific transcription factor TTF-1.
The Journal of clinical investigation 1995;96(2):781-5.
1995: M Rodríguez; F Rodríguez; T Jolin; Pilar Santisteban
Comparative effects of food restriction, fasting, diabetes and thyroidectomy on growth hormone and thyrotropin gene expression in the rat pituitary.
European journal of endocrinology / European Federation of Endocrine Societies 1995;133(1):110-6.
1994: C García-Jiménez; B Benito; T Jolin; Pilar Santisteban
Insulin regulation of malic enzyme gene expression in rat liver: evidence for nuclear proteins that bind to two putative insulin response elements.
Molecular endocrinology (Baltimore, Md.) 1994;8(10):1361-9.
1993: P Aza-Blanc; R Di Lauro; Pilar Santisteban
Identification of a cis-regulatory element and a thyroid-specific nuclear factor mediating the hormonal regulation of rat thyroid peroxidase promoter activity.
Molecular endocrinology (Baltimore, Md.) 1993;7(10):1297-306.
1993: A Hernandez; C Garcia-Jimenez; Pilar Santisteban; Maria Jesus Obregón
Regulation of malic-enzyme-gene expression by cAMP and retinoic acid in differentiating brown adipocytes.
European journal of biochemistry / FEBS 1993;215(2):285-90.
1993: C García-Jimenez; A Hernández; Maria Jesus Obregón; Pilar Santisteban
Malic enzyme gene expression in differentiating brown adipocytes: regulation by insulin and triiodothyronine.
Endocrinology 1993;132(4):1537-43.
1992: Pilar Santisteban; A Acebrón; Maria Polycarpou-Schwarz; Roberto Di Lauro
Insulin and insulin-like growth factor I regulate a thyroid-specific nuclear protein that binds to the thyroglobulin promoter.
Molecular endocrinology (Baltimore, Md.) 1992;6(8):1310-7.
1992: M Rodríguez; Pilar Santisteban; A Acebrón; L C Hernandez; M del Valle; T Jolin
Expression of thyroglobulin gene in maternal and fetal thyroid in rats.
Endocrinology 1992;131(1):415-22.
1991: Gabriela Bedo; Pilar Santisteban; T Jolin; Ana Aranda
Expression of the growth hormone gene and the pituitary-specific transcription factor GHF-1 in diabetic rats.
Molecular endocrinology (Baltimore, Md.) 1991;5(11):1730-9.
1989: Alan Jeffrey Hargreaves; L Lamas; Pilar Santisteban; Jesús Avila
Subcellular localization of iodinated thyroid tubulin.
Bioscience reports 1989;9(3):375-82.
1989: Gabriela Bedo; Pilar Santisteban; Ana Aranda
Retinoic acid regulates growth hormone gene expression.
Nature 1989;339(6221):231-4.
1986: L Lamas; Pilar Santisteban; C Turmo; A M Seguido
Evidence, by in vitro enzymatic iodination of thyroglobulin, that the efficiency of coupling is determined by the initial iodide concentration.
Endocrinology 1986;118(5):2131-6.
1985: Pilar Santisteban; Alan Jeffrey Hargreaves; J Cano; Jesús Avila; L Lamas
Effects of high doses of iodide on thyroid secretion: evidence for the presence of iodinated membrane tubulin.
Endocrinology 1985;117(2):607-12.
1984: Maria Jesus Obregón; Pilar Santisteban; A Rodríguez-Peña; A Pascual; P Cartagena; Antonio Ruiz-Marcos; L Lamas; Francisco Escobar del Rey; Gabriella Morreale de Escobar
Cerebral hypothyroidism in rats with adult-onset iodine deficiency.
Endocrinology 1984;115(2):614-24.
1982: Pilar Santisteban; Maria Jesus Obregón; A Rodriguez-Peña; L Lamas; F E Del Rey; G M De Escobar
Are iodine-deficient rats euthyroid?
Endocrinology 1982;110(5):1780-9.
1982: M F van den Hove-Vandenbroucke; Pilar Santisteban; M Couvreur; Maria Jesus Obregón; L Lamas
Involution of rat iodoprive hyperplastic goiter: effect of iodide administration on thyroid function and lysosomal properties.
Endocrinology 1982;110(5):1812-8.
1981: Pilar Santisteban; L Lamas
The effect of varying iodine content on the proteolytic activity of rat thyroid lysosomes.
Acta endocrinologica 1981;98(4):556-63.
1980: L Lamas; Pilar Santisteban
Re-evaluation of some factors affecting the stability of rat thyroglobulin.
Biochimica et biophysica acta 1980;621(2):265-72.