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Massimo Santoro
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105
Fusco, Alfredo
55
Melillo, Rosa Marina
45
Carlomagno, Francesca
42
Vecchio, Giancarlo
35
Chiappetta, Gennaro
34
Viglietto, Giuseppe
28
Salvatore, Giuliana
26
Fedele, Monica
23
Grieco, Michele
21
Basolo, Fulvio
21
Berlingieri, Maria Teresa
20
Castellone, Maria Domenica
20
Visconti, Roberta
19
De Vita, Gabriella
17
Pierantoni, Giovanna Maria
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All Publications
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2009: Moretti Sonia; De Falco Valentina; Tamburrino Anna; Barbi Flavia; Tavano Maria; Avenia Nicola; Santeusanio Fausto; Santoro Massimo; Macchiarulo Antonio; Puxeddu Efisio
Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif.
Biochimica et biophysica acta 2009;1793(11):1634-45.
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2009: Mancini Marcello; Vergara Emilia; Salvatore Giuliana; Greco Adelaide; Troncone Giancarlo; Affuso Andrea; Liuzzi Raffaele; Salerno Paolo; Scotto di Santolo Maria; Santoro Massimo; Brunetti Arturo; Salvatore Marco
Morphological ultrasound microimaging of thyroid in living mice.
Endocrinology 2009;150(10):4810-5.
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2009: Cerrato Aniello; De Falco Valentina; Santoro Massimo
Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets.
Journal of molecular endocrinology 2009;43(4):143-55.
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2009: Fedele Monica; Palmieri Dario; Chiappetta Gennaro; Pasquinelli Rosa; De Martino Ivana; Arra Claudio; Palma Giuseppe; Valentino Teresa; Pierantoni Giovanna M; Viglietto Giuseppe; Rothstein Jay L; Santoro Massimo; Fusco Alfredo
Impairment of the p27kip1 function enhances thyroid carcinogenesis in TRK-T1 transgenic mice.
Endocrine-related cancer 2009;16(2):483-90.
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2009: Nappi Tito Claudio; Salerno Paolo; Zitzelsberger Horst; Carlomagno Francesca; Salvatore Giuliana; Santoro Massimo
Identification of Polo-like kinase 1 as a potential therapeutic target in anaplastic thyroid carcinoma.
Cancer research 2009;69(5):1916-23.
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2009: Castellone Maria Domenica; De Falco Valentina; Rao Deva Magendra; Bellelli Roberto; Muthu Magesh; Basolo Fulvio; Fusco Alfredo; Gutkind J Silvio; Santoro Massimo
The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation.
Cancer research 2009;69(5):1867-76.
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2009: Carlomagno Francesca; Guida Teresa; Anaganti Suresh; Provitera Livia; Kjaer Svend; McDonald Neil Q; Ryan Anderson J; Santoro Massimo
Identification of tyrosine 806 as a molecular determinant of RET kinase sensitivity to ZD6474.
Endocrine-related cancer 2009;16(1):233-41.
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2008: Castellone Maria Domenica; Carlomagno Francesca; Salvatore Giuliana; Santoro Massimo
Receptor tyrosine kinase inhibitors in thyroid cancer.
Best practice & research. Clinical endocrinology & metabolism 2008;22(6):1023-38.
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2008: De Falco Valentina; Giannini Riccardo; Tamburrino Anna; Ugolini Clara; Lupi Cristiana; Puxeddu Efisio; Santoro Massimo; Basolo Fulvio
Functional characterization of the novel T599I-VKSRdel BRAF mutation in a follicular variant papillary thyroid carcinoma.
The Journal of clinical endocrinology and metabolism 2008;93(11):4398-402.
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2008: Pallante Pierlorenzo; Federico Antonella; Berlingieri Maria Teresa; Bianco Mimma; Ferraro Angelo; Forzati Floriana; Iaccarino Antonino; Russo Maria; Pierantoni Giovanna Maria; Leone Vincenza; Sacchetti Silvana; Troncone Giancarlo; Santoro Massimo; Fusco Alfredo
Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer.
Cancer research 2008;68(16):6770-8.
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2008: Salvatore Giuliana; Carlomagno Francesca; Santoro Massimo
Pros and cons of cellular studies in developing new drugs for thyroid cancers.
Thyroid : official journal of the American Thyroid Association 2008;18(8):819-22.
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2008: Castellone Maria Domenica; Santoro Massimo
Dysregulated RET signaling in thyroid cancer.
Endocrinology and metabolism clinics of North America 2008;37(2):363-74, viii.
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2008: Chiappetta Gennaro; Ferraro Angelo; Vuttariello Emilia; Monaco Mario; Galdiero Francesca; De Simone Veronica; Califano Daniela; Pallante Pierlorenzo; Botti Gerardo; Pezzullo Luciano; Pierantoni Giovanna Maria; Santoro Massimo; Fusco Alfredo
HMGA2 mRNA expression correlates with the malignant phenotype in human thyroid neoplasias.
European journal of cancer (Oxford, England : 1990) 2008;44(7):1015-21.
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2007: De Falco Valentina; Guarino Valentina; Avilla Elvira; Castellone Maria Domenica; Salerno Paolo; Salvatore Giuliana; Faviana Pinuccia; Basolo Fulvio; Santoro Massimo; Melillo Rosa Marina
Biological role and potential therapeutic targeting of the chemokine receptor CXCR4 in undifferentiated thyroid cancer.
Cancer research 2007;67(24):11821-9.
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2007: Staibano S; Merolla F; Testa D; Iovine R; Mascolo M; Guarino V; Castellone M D; Di Benedetto M; Galli V; Motta S; Melillo R M; De Rosa G; Santoro M; Celetti A
OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome.
British journal of cancer 2007;97(11):1545-51.
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2007: Motti Maria Letizia; De Marco Carmela; Califano Daniela; De Gisi Silvia; Malanga Donatella; Troncone Giancarlo; Persico Angela; Losito Simona; Fabiani Fernanda; Santoro Massimo; Chiappetta Gennaro; Fusco Alfredo; Viglietto Giuseppe
Loss of p27 expression through RAS-->BRAF-->MAP kinase-dependent pathway in human thyroid carcinomas.
Cell cycle (Georgetown, Tex.) 2007;6(22):2817-25.
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2007: Salvatore Giuliana; Nappi Tito Claudio; Salerno Paolo; Jiang Yuan; Garbi Corrado; Ugolini Clara; Miccoli Paolo; Basolo Fulvio; Castellone Maria Domenica; Cirafici Anna Maria; Melillo Rosa Marina; Fusco Alfredo; Bittner Michael L; Santoro Massimo
A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma.
Cancer research 2007;67(21):10148-58.
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2007: Lupi Cristiana; Giannini Riccardo; Ugolini Clara; Proietti Agnese; Berti Piero; Minuto Michele; Materazzi Gabriele; Elisei Rossella; Santoro Massimo; Miccoli Paolo; Basolo Fulvio
Association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma.
The Journal of clinical endocrinology and metabolism 2007;92(11):4085-90.
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2007: Visone R; Pallante P; Vecchione A; Cirombella R; Ferracin M; Ferraro A; Volinia S; Coluzzi S; Leone V; Borbone E; Liu C-G; Petrocca F; Troncone G; Calin G A; Scarpa A; Colato C; Tallini G; Santoro M; Croce C M; Fusco A
Specific microRNAs are downregulated in human thyroid anaplastic carcinomas.
Oncogene 2007;26(54):7590-5.
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2007: Giannini Riccardo; Ugolini Clara; Lupi Cristiana; Proietti Agnese; Elisei Rossella; Salvatore Giuliana; Berti Piero; Materazzi Gabriele; Miccoli Paolo; Santoro Massimo; Basolo Fulvio
The heterogeneous distribution of BRAF mutation supports the independent clonal origin of distinct tumor foci in multifocal papillary thyroid carcinoma.
The Journal of clinical endocrinology and metabolism 2007;92(9):3511-6.
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2007: Santoro Massimo; Fusco Alfredo
New drugs in thyroid cancer.
Arquivos brasileiros de endocrinologia e metabologia 2007;51(5):857-61.
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2007: Fusco Alfredo; Santoro Massimo
20 years of RET/PTC in thyroid cancer: clinico-pathological correlations.
Arquivos brasileiros de endocrinologia e metabologia 2007;51(5):731-5.
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2007: Guida Teresa; Anaganti Suresh; Provitera Livia; Gedrich Richard; Sullivan Elizabeth; Wilhelm Scott M; Santoro Massimo; Carlomagno Francesca
Sorafenib inhibits imatinib-resistant KIT and platelet-derived growth factor receptor beta gatekeeper mutants.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(11):3363-9.
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2007: Ugolini Clara; Giannini Riccardo; Lupi Cristiana; Salvatore Giuliana; Miccoli Paolo; Proietti Agnese; Elisei Rossella; Santoro Massimo; Basolo Fulvio
Presence of BRAF V600E in very early stages of papillary thyroid carcinoma.
Thyroid : official journal of the American Thyroid Association 2007;17(5):381-8.
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2007: De Falco Valentina; Castellone Maria Domenica; De Vita Gabriella; Cirafici Anna Maria; Hershman Jerome M; Guerrero Carmen; Fusco Alfredo; Melillo Rosa Marina; Santoro Massimo
RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase.
Cancer research 2007;67(1):381-90.
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2007: Minopoli Giuseppina; Passaro Fabiana; Aloia Luigi; Carlomagno Francesca; Melillo Rosa Marina; Santoro Massimo; Forzati Floriana; Zambrano Nicola; Russo Tommaso
Receptor- and non-receptor tyrosine kinases induce processing of the amyloid precursor protein: role of the low-density lipoprotein receptor-related protein.
Neuro-degenerative diseases 2007;4(2-3):94-100.
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2006: Santoro Massimo; Melillo Rosa Marina; Fusco Alfredo
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
European journal of endocrinology / European Federation of Endocrine Societies 2006;155(5):645-53.
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2006: Vitagliano D; Portella G; Troncone G; Francione A; Rossi C; Bruno A; Giorgini A; Coluzzi S; Nappi T C; Rothstein J L; Pasquinelli R; Chiappetta G; Terracciano D; Macchia V; Melillo R M; Fusco A; Santoro M
Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas.
Oncogene 2006;25(39):5467-74.
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2006: Moretti S; Macchiarulo A; De Falco V; Avenia N; Barbi F; Carta C; Cavaliere A; Melillo R M; Passeri L; Santeusanio F; Tartaglia M; Santoro M; Puxeddu E
Biochemical and molecular characterization of the novel BRAF(V599Ins) mutation detected in a classic papillary thyroid carcinoma.
Oncogene 2006;25(30):4235-40.
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2006: Pallante P; Visone R; Ferracin M; Ferraro A; Berlingieri M T; Troncone G; Chiappetta G; Liu C G; Santoro M; Negrini M; Croce C M; Fusco A
MicroRNA deregulation in human thyroid papillary carcinomas.
Endocrine-related cancer 2006;13(2):497-508.
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2006: Rhoden Kerry J; Unger Kristian; Salvatore Giuliana; Yilmaz Yesim; Vovk Volodymyr; Chiappetta Gennaro; Qumsiyeh Mazin B; Rothstein Jay L; Fusco Alfredo; Santoro Massimo; Zitzelsberger Horst; Tallini Giovanni
RET/papillary thyroid cancer rearrangement in nonneoplastic thyrocytes: follicular cells of Hashimoto's thyroiditis share low-level recombination events with a subset of papillary carcinoma.
The Journal of clinical endocrinology and metabolism 2006;91(6):2414-23.
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2006: Iavarone Carlo; Acunzo Mario; Carlomagno Francesca; Catania Annunziata; Melillo Rosa M; Carlomagno Stella M; Santoro Massimo; Chiariello Mario
Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.
The Journal of biological chemistry 2006;281(15):10567-76.
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2006: Salvatore Giuliana; De Falco Valentina; Salerno Paolo; Nappi Tito Claudio; Pepe Stefano; Troncone Giancarlo; Carlomagno Francesca; Melillo Rosa Marina; Wilhelm Scott M; Santoro Massimo
BRAF is a therapeutic target in aggressive thyroid carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(5):1623-9.
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2006: Carlomagno Francesca; Anaganti Suresh; Guida Teresa; Salvatore Giuliana; Troncone Giancarlo; Wilhelm Scott M; Santoro Massimo
BAY 43-9006 inhibition of oncogenic RET mutants.
Journal of the National Cancer Institute 2006;98(5):326-34.
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2006: D'Aloiso Leonardo; Carlomagno Francesca; Bisceglia Michele; Anaganti Suresh; Ferretti Elisabetta; Verrienti Antonella; Arturi Franco; Scarpelli Daniela; Russo Diego; Santoro Massimo; Filetti Sebastiano
Clinical case seminar: in vivo and in vitro characterization of a novel germline RET mutation associated with low-penetrant nonaggressive familial medullary thyroid carcinoma.
The Journal of clinical endocrinology and metabolism 2006;91(3):754-9.
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2006: Santoro Massimo; Carlomagno Francesca
Drug insight: Small-molecule inhibitors of protein kinases in the treatment of thyroid cancer.
Nature clinical practice. Endocrinology & metabolism 2006;2(1):42-52.
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2005: Celetti Angela; Testa Domenico; Staibano Stefania; Merolla Francesco; Guarino Valentina; Castellone Maria Domenica; Iovine Renata; Mansueto Gelsomina; Somma Pasquale; De Rosa Gaetano; Galli Vieri; Melillo Rosa Marina; Santoro Massimo
Overexpression of the cytokine osteopontin identifies aggressive laryngeal squamous cell carcinomas and enhances carcinoma cell proliferation and invasiveness.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(22):8019-27.
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2005: Donati Valentina; Boldrini Laura; Dell'Omodarme Matteo; Prati Maria C; Faviana Pinuccia; Camacci Tiziano; Lucchi Marco; Mussi Alfredo; Santoro Massimo; Basolo Fulvio; Fontanini Gabriella
Osteopontin expression and prognostic significance in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(18):6459-65.
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2005: Guarino Valentina; Faviana Pinuccia; Salvatore Giuliana; Castellone Maria Domenica; Cirafici Anna Maria; De Falco Valentina; Celetti Angela; Giannini Riccardo; Basolo Fulvio; Melillo Rosa Marina; Santoro Massimo
Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness.
The Journal of clinical endocrinology and metabolism 2005;90(9):5270-8.
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2005: De Falco Valentina; Guarino Valentina; Malorni Luca; Cirafici Anna Maria; Troglio Flavia; Erreni Marco; Pelicci Giuliana; Santoro Massimo; Melillo Rosa Marina
RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors.
Oncogene 2005;24(41):6303-13.
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2005: Pallante P; Berlingieri M T; Troncone G; Kruhoffer M; Orntoft T F; Viglietto G; Caleo A; Migliaccio I; Decaussin-Petrucci M; Santoro M; Palombini L; Fusco A
UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas.
British journal of cancer 2005;93(4):464-71.
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2005: Boldrini L; Donati V; Dell'Omodarme M; Prati M C; Faviana P; Camacci T; Lucchi M; Mussi A; Santoro M; Basolo F; Fontanini G
Prognostic significance of osteopontin expression in early-stage non-small-cell lung cancer.
British journal of cancer 2005;93(4):453-7.
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2005: Guida Teresa; Salvatore Giuliana; Faviana Pinuccia; Giannini Riccardo; Garcia-Rostan Ginesa; Provitera Livia; Basolo Fulvio; Fusco Alfredo; Carlomagno Francesca; Santoro Massimo
Mitogenic effects of the up-regulation of minichromosome maintenance proteins in anaplastic thyroid carcinoma.
The Journal of clinical endocrinology and metabolism 2005;90(8):4703-9.
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2005: Melillo Rosa Marina; Castellone Maria Domenica; Guarino Valentina; De Falco Valentina; Cirafici Anna Maria; Salvatore Giuliana; Caiazzo Fiorina; Basolo Fulvio; Giannini Riccardo; Kruhoffer Mogens; Orntoft Torben; Fusco Alfredo; Santoro Massimo
The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells.
The Journal of clinical investigation 2005;115(4):1068-81.
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2005: Salvatore Giuliana; Chiappetta Gennaro; Nikiforov Yuri E; Decaussin-Petrucci Myriam; Fusco Alfredo; Carney J Aidan; Santoro Massimo
Molecular profile of hyalinizing trabecular tumours of the thyroid: high prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutations.
European journal of cancer (Oxford, England : 1990) 2005;41(5):816-21.
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2005: Fusco Alfredo; Viglietto Giuseppe; Santoro Massimo
A new mechanism of BRAF activation in human thyroid papillary carcinomas.
The Journal of clinical investigation 2005;115(1):20-3.
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2005: Carlomagno Francesca; Santoro Massimo
Receptor tyrosine kinases as targets for anticancer therapeutics.
Current medicinal chemistry 2005;12(15):1773-81.
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2004: Santoro M; Carlomagno F; Melillo R M; Fusco A
Dysfunction of the RET receptor in human cancer.
Cellular and molecular life sciences : CMLS 2004;61(23):2954-64.
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2004: Santoro Massimo; Melillo Rosa Marina; Carlomagno Francesca; Vecchio Giancarlo; Fusco Alfredo
Minireview: RET: normal and abnormal functions.
Endocrinology 2004;145(12):5448-51.
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2004: Carlomagno F; Santoro M
Identification of RET kinase inhibitors as potential new treatment for sporadic and inherited thyroid cancer.
Journal of chemotherapy (Florence, Italy) 2004;16 Suppl 4():49-51.
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2004: Salvatore Giuliana; Giannini Riccardo; Faviana Pinuccia; Caleo Alessia; Migliaccio Ilenia; Fagin James A; Nikiforov Yuri E; Troncone Giancarlo; Palombini Lucio; Basolo Fulvio; Santoro Massimo
Analysis of BRAF point mutation and RET/PTC rearrangement refines the fine-needle aspiration diagnosis of papillary thyroid carcinoma.
The Journal of clinical endocrinology and metabolism 2004;89(10):5175-80.
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2004: Orgiana G; Pinna G; Camedda A; De Falco V; Santoro M; Melillo R M; Elisei R; Romei C; Lai S; Carcassi C; Mariotti S
A new germline RET mutation apparently devoid of transforming activity serendipitously discovered in a patient with atrophic autoimmune thyroiditis and primary ovarian failure.
The Journal of clinical endocrinology and metabolism 2004;89(10):4810-6.
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2004: Unger Kristian; Zitzelsberger Horst; Salvatore Giuliana; Santoro Massimo; Bogdanova Tatjana; Braselmann Herbert; Kastner Peter; Zurnadzhy Lyudmilla; Tronko Nikolay; Hutzler Peter; Thomas Gerry
Heterogeneity in the distribution of RET/PTC rearrangements within individual post-Chernobyl papillary thyroid carcinomas.
The Journal of clinical endocrinology and metabolism 2004;89(9):4272-9.
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2004: Melillo Rosa Marina; Cirafici Anna Maria; De Falco Valentina; Bellantoni Marie; Chiappetta Gennaro; Fusco Alfredo; Carlomagno Francesca; Picascia Antonella; Tramontano Donatella; Tallini Giovanni; Santoro Massimo
The oncogenic activity of RET point mutants for follicular thyroid cells may account for the occurrence of papillary thyroid carcinoma in patients affected by familial medullary thyroid carcinoma.
The American journal of pathology 2004;165(2):511-21.
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2004: Castellone Maria D; Guarino Valentina; De Falco Valentina; Carlomagno Francesca; Basolo Fulvio; Faviana Pinuccia; Kruhoffer Mogens; Orntoft Torben; Russell John P; Rothstein Jay L; Fusco Alfredo; Santoro Massimo; Melillo Rosa Marina
Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas.
Oncogene 2004;23(35):5958-67.
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2004: Carlomagno Francesca; Guida Teresa; Anaganti Suresh; Vecchio Giancarlo; Fusco Alfredo; Ryan Anderson J; Billaud Marc; Santoro Massimo
Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors.
Oncogene 2004;23(36):6056-63.
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2004: Vitagliano Donata; Carlomagno Francesca; Motti Maria Letizia; Viglietto Giuseppe; Nikiforov Yuri E; Nikiforova Marina N; Hershman Jerome M; Ryan Anderson J; Fusco Alfredo; Melillo Rosa Marina; Santoro Massimo
Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells.
Cancer research 2004;64(11):3823-9.
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2004: Castellone Maria Domenica; Celetti Angela; Guarino Valentina; Cirafici Anna Maria; Basolo Fulvio; Giannini Riccardo; Medico Enzo; Kruhoffer Mogens; Orntoft Torben F; Curcio Francesco; Fusco Alfredo; Melillo Rosa Marina; Santoro Massimo
Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells.
Oncogene 2004;23(12):2188-96.
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2004: Spalletti-Cernia D; Sorrentino R; Di Gaetano S; Piccoli R; Santoro M; D'Alessio G; Laccetti P; Vecchio G
Highly selective toxic and proapoptotic effects of two dimeric ribonucleases on thyroid cancer cells compared to the effects of doxorubicin.
British journal of cancer 2004;90(1):270-7.
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2003: Pierantoni Giovanna Maria; Battista Sabrina; Pentimalli Francesca; Fedele Monica; Visone Rosa; Federico Antonella; Santoro Massimo; Viglietto Giuseppe; Fusco Alfredo
A truncated HMGA1 gene induces proliferation of the 3T3-L1 pre-adipocytic cells: a model of human lipomas.
Carcinogenesis 2003;24(12):1861-9.
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2003: Pentimalli Francesca; Dentice Monica; Fedele Monica; Pierantoni Giovanna Maria; Cito Letizia; Pallante Pierlorenzo; Santoro Massimo; Viglietto Giuseppe; Dal Cin Paola; Fusco Alfredo
Suppression of HMGA2 protein synthesis could be a tool for the therapy of well differentiated liposarcomas overexpressing HMGA2.
Cancer research 2003;63(21):7423-7.
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2003: Pierantoni Giovanna Maria; Santulli Basilia; Caliendo Irene; Pentimalli Francesca; Chiappetta Gennaro; Zanesi Nicola; Santoro Massimo; Bulrich Florencia; Fusco Alfredo
HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia.
International journal of oncology 2003;23(2):363-7.
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2003: Russell John P; Shinohara Shogo; Melillo Rosa M; Castellone Maria D; Santoro Massimo; Rothstein Jay L
Tyrosine kinase oncoprotein, RET/PTC3, induces the secretion of myeloid growth and chemotactic factors.
Oncogene 2003;22(29):4569-77.
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2003: Spalletti-Cernia Daniela; Sorrentino Rosanna; Di Gaetano Sonia; Arciello Angela; Garbi Corrado; Piccoli Renata; D'Alessio Giuseppe; Vecchio Giancarlo; Laccetti Paolo; Santoro Massimo
Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis.
The Journal of clinical endocrinology and metabolism 2003;88(6):2900-7.
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2003: Andreozzi Francesco; Melillo Rosa Marina; Carlomagno Francesca; Oriente Francesco; Miele Claudia; Fiory Francesca; Santopietro Stefania; Castellone Maria Domenica; Beguinot Francesco; Santoro Massimo; Formisano Pietro
Protein kinase Calpha activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase.
Oncogene 2003;22(19):2942-9.
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2003: Carlomagno Francesca; Vitagliano Donata; Guida Teresa; Basolo Fulvio; Castellone Maria Domenica; Melillo Rosa Marina; Fusco Alfredo; Santoro Massimo
Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).
The Journal of clinical endocrinology and metabolism 2003;88(4):1897-902.
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2003: Santoro M; Melillo R M; Carlomagno F; Castellone M D; Vitagliano D; Guida T; Vecchio G; Fusco A
Genetic alterations in differentiated thyroid cancer: what can be expected for gene expression profiling of thyroid carcinomas.
Annales d'endocrinologie 2003;64(1):62-3.
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2003: Visconti Roberta; Schepis Filippo; Iuliano Rodolfo; Pierantoni Giovanna Maria; Zhang Li; Carlomagno Francesca; Battaglia Caterina; Martelli Maria Luisa; Trapasso Francesco; Santoro Massimo; Fusco Alfredo
Cloning and molecular characterization of a novel gene strongly induced by the adenovirus E1A gene in rat thyroid cells.
Oncogene 2003;22(7):1087-97.
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2003: Iuliano Rodolfo; Trapasso Francesco; Le Pera Ilaria; Schepis Filippo; Samà Irene; Clodomiro Alessandra; Dumon Kristoffel R; Santoro Massimo; Chiariotti Lorenzo; Viglietto Giuseppe; Fusco Alfredo
An adenovirus carrying the rat protein tyrosine phosphatase eta suppresses the growth of human thyroid carcinoma cell lines in vitro and in vivo.
Cancer research 2003;63(4):882-6.
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2003: Castellone Maria Domenica; Cirafici Anna Maria; De Vita Gabriella; De Falco Valentina; Malorni Luca; Tallini Giovanni; Fagin James A; Fusco Alfredo; Melillo Rosa Marina; Santoro Massimo
Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes.
Oncogene 2003;22(2):246-55.
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2002: Carlomagno Francesca; Vitagliano Donata; Guida Teresa; Ciardiello Fortunato; Tortora Giampaolo; Vecchio Giancarlo; Ryan Anderson J; Fontanini Gabriella; Fusco Alfredo; Santoro Massimo
ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases.
Cancer research 2002;62(24):7284-90.
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2002: Martelli Maria Luisa; Iuliano Rodolfo; Le Pera Ilaria; Sama' Irene; Monaco Carmen; Cammarota Simona; Kroll Todd; Chiariotti Lorenzo; Santoro Massimo; Fusco Alfredo
Inhibitory effects of peroxisome poliferator-activated receptor gamma on thyroid carcinoma cell growth.
The Journal of clinical endocrinology and metabolism 2002;87(10):4728-35.
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2002: Viglietto Giuseppe; Motti Maria Letizia; Bruni Paola; Melillo Rosa Marina; D'Alessio Amelia; Califano Daniela; Vinci Floriana; Chiappetta Gennaro; Tsichlis Philip; Bellacosa Alfonso; Fusco Alfredo; Santoro Massimo
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.
Nature medicine 2002;8(10):1136-44.
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2002: Pelicci Giuliana; Troglio Flavia; Bodini Alessandra; Melillo Rosa Marina; Pettirossi Valentina; Coda Laura; De Giuseppe Antonio; Santoro Massimo; Pelicci Pier Giuseppe
The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.
Molecular and cellular biology 2002;22(20):7351-63.
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2002: Santoro Massimo; Melillo Rosa Marina; Carlomagno Francesca; Fusco Alfredo; Vecchio Giancarlo
Molecular mechanisms of RET activation in human cancer.
Annals of the New York Academy of Sciences 2002;963():116-21.
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2002: Fusco Alfredo; Chiappetta Gennaro; Hui Pei; Garcia-Rostan Ginesa; Golden Lauren; Kinder Barbara K; Dillon Deborah A; Giuliano Ada; Cirafici Anna Maria; Santoro Massimo; Rosai Juan; Tallini Giovanni
Assessment of RET/PTC oncogene activation and clonality in thyroid nodules with incomplete morphological evidence of papillary carcinoma: a search for the early precursors of papillary cancer.
The American journal of pathology 2002;160(6):2157-67.
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2002: Fedele Monica; Battista Sabrina; Kenyon Lawrence; Baldassarre Gustavo; Fidanza Vincenzo; Klein-Szanto Andres J P; Parlow A F; Visone Rosa; Pierantoni Giovanna M; Outwater Eric; Santoro Massimo; Croce Carlo M; Fusco Alfredo
Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas.
Oncogene 2002;21(20):3190-8.
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2002: Berlingieri Maria Teresa; Pierantoni Giovanna M; Giancotti Vincenzo; Santoro Massimo; Fusco Alfredo
Thyroid cell transformation requires the expression of the HMGA1 proteins.
Oncogene 2002;21(19):2971-80.
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2002: Baldassarre Gustavo; Bruni Paola; Boccia Angelo; Salvatore Giuliana; Melillo Rosa Marina; Motti Maria Letizia; Napolitano Maria; Belletti Barbara; Fusco Alfredo; Santoro Massimo; Viglietto Giuseppe
Glial cell line-derived neurotrophic factor induces proliferative inhibition of NT2/D1 cells through RET-mediated up-regulation of the cyclin-dependent kinase inhibitor p27(kip1).
Oncogene 2002;21(11):1739-49.
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2002: Carlomagno Francesca; Vitagliano Donata; Guida Teresa; Napolitano Maria; Vecchio Giancarlo; Fusco Alfredo; Gazit Aviv; Levitzki Alexander; Santoro Massimo
The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes.
Cancer research 2002;62(4):1077-82.
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2002: Basolo Fulvio; Giannini Riccardo; Toniolo Antonio; Casalone Rosario; Nikiforova Marina; Pacini Furio; Elisei Rossella; Miccoli Paolo; Berti Piero; Faviana Pinuccia; Fiore Lisa; Monaco Carmen; Pierantoni Giovanna Maria; Fedele Monica; Nikiforov Yuri E; Santoro Massimo; Fusco Alfredo
Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement.
International journal of cancer. Journal international du cancer 2002;97(5):608-14.
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2002: Pierantoni Giovanna Maria; Bulfone Alessandro; Pentimalli Francesca; Fedele Monica; Iuliano Rodolfo; Santoro Massimo; Chiariotti Lorenzo; Ballabio Andrea; Fusco Alfredo
The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues.
Biochemical and biophysical research communications 2002;290(3):942-7.
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2002: Santoro Massimo; Papotti Mauro; Chiappetta Gennaro; Garcia-Rostan Ginesa; Volante Marco; Johnson Chaline; Camp Robert L; Pentimalli Francesca; Monaco Carmen; Herrero Agustin; Carcangiu Maria Luisa; Fusco Alfredo; Tallini Giovanni
RET activation and clinicopathologic features in poorly differentiated thyroid tumors.
The Journal of clinical endocrinology and metabolism 2002;87(1):370-9.
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2002: Chiappetta Gennaro; Toti Paolo; Cetta Francesco; Giuliano Ada; Pentimalli Francesca; Amendola Ida; Lazzi Stefano; Monaco Mario; Mazzuchelli Luca; Tosi Piero; Santoro Massimo; Fusco Alfredo
The RET/PTC oncogene is frequently activated in oncocytic thyroid tumors (Hurthle cell adenomas and carcinomas), but not in oncocytic hyperplastic lesions.
The Journal of clinical endocrinology and metabolism 2002;87(1):364-9.
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2002: Basolo Fulvio; Giannini Riccardo; Monaco Carmen; Melillo Rosa Marina; Carlomagno Francesca; Pancrazi Martina; Salvatore Giuliana; Chiappetta Gennaro; Pacini Furio; Elisei Rossella; Miccoli Paolo; Pinchera Aldo; Fusco Alfredo; Santoro Massimo
Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma.
The American journal of pathology 2002;160(1):247-54.
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2001: Basolo F; Molinaro E; Agate L; Pinchera A; Pollina L; Chiappetta G; Monaco C; Santoro M; Fusco A; Miccoli P; Elisei R; Capezzone M; Pacini F
RET protein expression has no prognostic impact on the long-term outcome of papillary thyroid carcinoma.
European journal of endocrinology / European Federation of Endocrine Societies 2001;145(5):599-604.
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2001: Barone M V; Sepe L; Melillo R M; Mineo A; Santelli G; Monaco C; Castellone M D; Tramontano D; Fusco A; Santoro M
RET/PTC1 oncogene signaling in PC Cl 3 thyroid cells requires the small GTP-binding protein Rho.
Oncogene 2001;20(48):6973-82.
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2001: Manié S; Santoro M; Fusco A; Billaud M
The RET receptor: function in development and dysfunction in congenital malformation.
Trends in genetics : TIG 2001;17(10):580-9.
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2001: Pero R; Lembo F; Di Vizio D; Boccia A; Chieffi P; Fedele M; Pierantoni G M; Rossi P; Iuliano R; Santoro M; Viglietto G; Bruni C B; Fusco A; Chiariotti L
RNF4 is a growth inhibitor expressed in germ cells but not in human testicular tumors.
The American journal of pathology 2001;159(4):1225-30.
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2001: Pierantoni G M; Fedele M; Pentimalli F; Benvenuto G; Pero R; Viglietto G; Santoro M; Chiariotti L; Fusco A
High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth.
Oncogene 2001;20(43):6132-41.
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2001: Baldassarre G; Fedele M; Battista S; Vecchione A; Klein-Szanto A J; Santoro M; Waldmann T A; Azimi N; Croce C M; Fusco A
Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(14):7970-5.
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2001: Melillo R M; Santoro M; Ong S H; Billaud M; Fusco A; Hadari Y R; Schlessinger J; Lax I
Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade.
Molecular and cellular biology 2001;21(13):4177-87.
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2001: Iuliano R; Trapasso F; Samà I; Le Pera I; Martelli M L; Lembo F; Santoro M; Viglietto G; Chiariotti L; Fusco A
Rat protein tyrosine phosphatase eta physically interacts with the PDZ domains of syntenin.
FEBS letters 2001;500(1-2):41-4.
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2001: Fedele M; Pierantoni G M; Berlingieri M T; Battista S; Baldassarre G; Munshi N; Dentice M; Thanos D; Santoro M; Viglietto G; Fusco A
Overexpression of proteins HMGA1 induces cell cycle deregulation and apoptosis in normal rat thyroid cells.
Cancer research 2001;61(11):4583-90.
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2001: Melillo R M; Pierantoni G M; Scala S; Battista S; Fedele M; Stella A; De Biasio M C; Chiappetta G; Fidanza V; Condorelli G; Santoro M; Croce C M; Viglietto G; Fusco A
Critical role of the HMGI(Y) proteins in adipocytic cell growth and differentiation.
Molecular and cellular biology 2001;21(7):2485-95.
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2001: de Nigris F; Mega T; Berger N; Barone M V; Santoro M; Viglietto G; Verde P; Fusco A
Induction of ETS-1 and ETS-2 transcription factors is required for thyroid cell transformation.
Cancer research 2001;61(5):2267-75.
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2001: Monaco C; Visconti R; Barone M V; Pierantoni G M; Berlingieri M T; De Lorenzo C; Mineo A; Vecchio G; Fusco A; Santoro M
The RFG oligomerization domain mediates kinase activation and re-localization of the RET/PTC3 oncoprotein to the plasma membrane.
Oncogene 2001;20(5):599-608.
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2001: Salvatore D; Melillo R M; Monaco C; Visconti R; Fenzi G; Vecchio G; Fusco A; Santoro M
Increased in vivo phosphorylation of ret tyrosine 1062 is a potential pathogenetic mechanism of multiple endocrine neoplasia type 2B.
Cancer research 2001;61(4):1426-31.
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2001: Melillo R M; Carlomagno F; De Vita G; Formisano P; Vecchio G; Fusco A; Billaud M; Santoro M
The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret.
Oncogene 2001;20(2):209-18.
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2001: Chiappetta G; Manfioletti G; Pentimalli F; Abe N; Di Bonito M; Vento M T; Giuliano A; Fedele M; Viglietto G; Santoro M; Watanabe T; Giancotti V; Fusco A
High mobility group HMGI(Y) protein expression in human colorectal hyperplastic and neoplastic diseases.
International journal of cancer. Journal international du cancer 2001;91(2):147-51.
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2001: Portella G; Borselli C; Santoro M; Gerbasio D; D'Armiento M R; Dumont J E; Ledent C; Rothstein J L; Vecchio G; Fusco A
Human papilloma virus 16 E7 oncogene does not cooperate with RET/PTC 3 oncogene in the neoplastic transformation of thyroid cells in transgenic mice.
Oncology research 2001;12(8):347-54.
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2000: Papotti M; Volante M; Giuliano A; Fassina A; Fusco A; Bussolati G; Santoro M; Chiappetta G
RET/PTC activation in hyalinizing trabecular tumors of the thyroid.
The American journal of surgical pathology 2000;24(12):1615-21.
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2000: Trapasso F; Iuliano R; Boccia A; Stella A; Visconti R; Bruni P; Baldassarre G; Santoro M; Viglietto G; Fusco A
Rat protein tyrosine phosphatase eta suppresses the neoplastic phenotype of retrovirally transformed thyroid cells through the stabilization of p27(Kip1).
Molecular and cellular biology 2000;20(24):9236-46.
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2000: Russell J P; Powell D J; Cunnane M; Greco A; Portella G; Santoro M; Fusco A; Rothstein J L
The TRK-T1 fusion protein induces neoplastic transformation of thyroid epithelium.
Oncogene 2000;19(50):5729-35.
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2000: Chiappetta G; Tallini G; De Biasio M C; Pentimalli F; de Nigris F; Losito S; Fedele M; Battista S; Verde P; Santoro M; Fusco A
FRA-1 expression in hyperplastic and neoplastic thyroid diseases.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(11):4300-6.
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2000: Iuliano R; Trapasso F; Stella A; Le Pera I; Melillo R M; Bruni P; Baldassarre G; Chiariotti L; Santoro M; Viglietto G; Fusco A
Pivotal role of the RB family proteins in in vitro thyroid cell transformation.
Experimental cell research 2000;260(2):257-67.
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2000: Salvatore D; Barone M V; Salvatore G; Melillo R M; Chiappetta G; Mineo A; Fenzi G; Vecchio G; Fusco A; Santoro M
Tyrosines 1015 and 1062 are in vivo autophosphorylation sites in ret and ret-derived oncoproteins.
The Journal of clinical endocrinology and metabolism 2000;85(10):3898-907.
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2000: Martelli M L; Miano M G; Battaglia C; Trapasso F; Stella A; Iuliano R; Visconti R; Fagin J A; Santoro M; Fusco A
The highly malignant phenotype of anaplastic thyroid carcinoma cell lines is recessive.
European journal of endocrinology / European Federation of Endocrine Societies 2000;143(4):515-21.
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2000: De Vita G; Berlingieri M T; Visconti R; Castellone M D; Viglietto G; Baldassarre G; Zannini M; Bellacosa A; Tsichlis P N; Fusco A; Santoro M
Akt/protein kinase B promotes survival and hormone-independent proliferation of thyroid cells in the absence of dedifferentiating and transforming effects.
Cancer research 2000;60(14):3916-20.
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2000: De Vita G; Melillo R M; Carlomagno F; Visconti R; Castellone M D; Bellacosa A; Billaud M; Fusco A; Tsichlis P N; Santoro M
Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival.
Cancer research 2000;60(14):3727-31.
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2000: Bruni P; Boccia A; Baldassarre G; Trapasso F; Santoro M; Chiappetta G; Fusco A; Viglietto G
PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1.
Oncogene 2000;19(28):3146-55.
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2000: Viglietto G; Dolci S; Bruni P; Baldassarre G; Chiariotti L; Melillo R M; Salvatore G; Chiappetta G; Sferratore F; Fusco A; Santoro M
Glial cell line-derived neutrotrophic factor and neurturin can act as paracrine growth factors stimulating DNA synthesis of Ret-expressing spermatogonia.
International journal of oncology 2000;16(4):689-94.
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2000: Fedele M; Benvenuto G; Pero R; Majello B; Battista S; Lembo F; Vollono E; Day P M; Santoro M; Lania L; Bruni C B; Fusco A; Chiariotti L
A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor.
The Journal of biological chemistry 2000;275(11):7894-901.
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2000: Villone G; De Vita G; Chieffi P; Picascia A; Stanzione R; Santoro M; Fusco A; Tramontano D
Association between the expression of E1A oncogene and increased sensitivity to growth inhibition induced by sustained levels of cAMP in rat thyroid cells.
European journal of endocrinology / European Federation of Endocrine Societies 2000;142(3):286-93.
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2000: Giannini R; Salvatore G; Monaco C; Sferratore F; Pollina L; Pacini F; Basolo F; Fusco A; Santoro M
Identification of a novel subtype of H4-RET rearrangement in a thyroid papillary carcinoma and lymph node metastasis.
International journal of oncology 2000;16(3):485-9.
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2000: Vecchio G; Santoro M
Oncogenes and thyroid cancer.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2000;38(2):113-6.
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2000: Santoro M; Thomas G A; Vecchio G; Williams G H; Fusco A; Chiappetta G; Pozcharskaya V; Bogdanova T I; Demidchik E P; Cherstvoy E D; Voscoboinik L; Tronko N D; Carss A; Bunnell H; Tonnachera M; Parma J; Dumont J E; Keller G; Höfler H; Williams E D
Gene rearrangement and Chernobyl related thyroid cancers.
British journal of cancer 2000;82(2):315-22.
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1999: Santoro M; Carlomagno F; Melillo R M; Billaud M; Vecchio G; Fusco A
Molecular mechanisms of RET activation in human neoplasia.
Journal of endocrinological investigation 1999;22(10):811-9.
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1999: Thomas G A; Bunnell H; Cook H A; Williams E D; Nerovnya A; Cherstvoy E D; Tronko N D; Bogdanova T I; Chiappetta G; Viglietto G; Pentimalli F; Salvatore G; Fusco A; Santoro M; Vecchio G
High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant.
The Journal of clinical endocrinology and metabolism 1999;84(11):4232-8.
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1999: Battista S; Fidanza V; Fedele M; Klein-Szanto A J; Outwater E; Brunner H; Santoro M; Croce C M; Fusco A
The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis.
Cancer research 1999;59(19):4793-7.
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1999: Geneste O; Bidaud C; De Vita G; Hofstra R M; Tartare-Deckert S; Buys C H; Lenoir G M; Santoro M; Billaud M
Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effectors to a multifunctional docking site.
Human molecular genetics 1999;8(11):1989-99.
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1999: Viglietto G; Califano D; Bruni P; Baldassarre G; Vento M T; Belletti B; Fedele M; Santelli G; Boccia A; Manzo G; Santoro M; Fusco A
Regulation of thymosin beta10 expression by TSH and other mitogenic signals in the thyroid gland and in cultured thyrocytes.
European journal of endocrinology / European Federation of Endocrine Societies 1999;140(6):597-607.
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1999: Santoro M; Melillo R M; Carlomagno F; Visconti R; De Vita G; Salvatore G; Fusco A; Vecchio G
Different mutations of the RET gene cause different human tumoral diseases.
Biochimie 1999;81(4):397-402.
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1999: Melillo R M; Barone M V; Lupoli G; Cirafici A M; Carlomagno F; Visconti R; Matoskova B; Di Fiore P P; Vecchio G; Fusco A; Santoro M
Ret-mediated mitogenesis requires Src kinase activity.
Cancer research 1999;59(5):1120-6.
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1999: Forestieri P; De Luca M; Formato A; Loffredo A; Santoro M
Restrictive versus malabsorptive procedures: criteria for patient selection.
Obesity surgery 1999;9(1):48-50.
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1999: Portella G; Vitagliano D; Borselli C; Melillo R M; Salvatore D; Rothstein J L; Vecchio G; Fusco A; Santoro M
Human N-ras, TRK-T1, and RET/PTC3 oncogenes, driven by a thyroglobulin promoter, differently affect the expression of differentiation markers and the proliferation of thyroid epithelial cells.
Oncology research 1999;11(9):421-7.
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1998: Chappuis-Flament S; Pasini A; De Vita G; Ségouffin-Cariou C; Fusco A; Attié T; Lenoir G M; Santoro M; Billaud M
Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines.
Oncogene 1998;17(22):2851-61.
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1998: Powell D J; Russell J; Nibu K; Li G; Rhee E; Liao M; Goldstein M; Keane W M; Santoro M; Fusco A; Rothstein J L
The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids.
Cancer research 1998;58(23):5523-8.
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1998: Martelli M L; Trapasso F; Bruni P; Berlingieri M T; Battaglia C; Vento M T; Belletti B; Iuliano R; Santoro M; Viglietto G; Fusco A
Protein tyrosine phosphatase-eta expression is upregulated by the PKA-dependent and is downregulated by the PKC-dependent pathways in thyroid cells.
Experimental cell research 1998;245(1):195-202.
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1998: Santoro A; Santoro M; Maiorino L; Forestieri V; Forestieri P
Primary non-Hodgkin's lymphoma of the liver: case report.
Journal of chemotherapy (Florence, Italy) 1998;10(5):422-4.
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1998: de Nigris F; Visconti R; Cerutti J; Califano D; Mineo A; Santoro M; Santelli G; Fusco A
Overexpression of the HIP gene coding for a heparin/heparan sulfate-binding protein in human thyroid carcinomas.
Cancer research 1998;58(20):4745-51.
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1998: Chiappetta G; Tallini G; De Biasio M C; Manfioletti G; Martinez-Tello F J; Pentimalli F; de Nigris F; Mastro A; Botti G; Fedele M; Berger N; Santoro M; Giancotti V; Fusco A
Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma.
Cancer research 1998;58(18):4193-8.
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1998: Carlomagno F; Melillo R M; Visconti R; Salvatore G; De Vita G; Lupoli G; Yu Y; Jing S; Vecchio G; Fusco A; Santoro M
Glial cell line-derived neurotrophic factor differentially stimulates ret mutants associated with the multiple endocrine neoplasia type 2 syndromes and Hirschsprung's disease.
Endocrinology 1998;139(8):3613-9.
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1998: Fedele M; Berlingieri M T; Scala S; Chiariotti L; Viglietto G; Rippel V; Bullerdiek J; Santoro M; Fusco A
Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts.
Oncogene 1998;17(4):413-8.
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1998: Battista S; de Nigris F; Fedele M; Chiappetta G; Scala S; Vallone D; Pierantoni G M; Mega T; Santoro M; Viglietto G; Verde P; Fusco A;
Increase in AP-1 activity is a general event in thyroid cell transformation in vitro and in vivo.
Oncogene 1998;17(3):377-85.
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1998: Santoro M; Melillo R M; Carlomagno F; Visconti R; De Vita G; Salvatore G; Lupoli G; Fusco A; Vecchio G
Molecular biology of the MEN2 gene.
Journal of internal medicine 1998;243(6):505-8.
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1998: Chiariello M; Visconti R; Carlomagno F; Melillo R M; Bucci C; de Franciscis V; Fox G M; Jing S; Coso O A; Gutkind J S; Fusco A; Santoro M
Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKS): evidence for a divergence of the ERKs and JNKs pathways induced by Ret.
Oncogene 1998;16(19):2435-45.
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1998: Califano D; Monaco C; Santelli G; Giuliano A; Veronese M L; Berlingieri M T; de Franciscis V; Berger N; Trapasso F; Santoro M; Viglietto G; Fusco A
Thymosin beta-10 gene overexpression correlated with the highly malignant neoplastic phenotype of transformed thyroid cells in vivo and in vitro.
Cancer research 1998;58(4):823-8.
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1998: Pacini F; Vivaldi A; Santoro M; Fedele M; Fusco A; Romei C; Basolo F; Pinchera A
Simian virus 40-like DNA sequences in human papillary thyroid carcinomas.
Oncogene 1998;16(5):665-9.
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1998: Chiariotti L; Benvenuto G; Fedele M; Santoro M; Simeone A; Fusco A; Bruni C B
Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3.
Genomics 1998;47(2):258-65.
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1998: De Vita G; Zannini M; Cirafici A M; Melillo R M; Di Lauro R; Fusco A; Santoro M
Expression of the RET/PTC1 oncogene impairs the activity of TTF-1 and Pax-8 thyroid transcription factors.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(1):97-103.
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1998: Portella G; Vitagliano D; Li Z; Sferratore F; Santoro M; Vecchio G; Fusco A
TPA induces a block of differentiation and increases the susceptibility to neoplastic transformation of a rat thyroid epithelial cell line.
Oncology research 1998;10(9):441-7.
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1997: Visconti R; Cerutti J; Battista S; Fedele M; Trapasso F; Zeki K; Miano M P; de Nigris F; Casalino L; Curcio F; Santoro M; Fusco A
Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression.
Oncogene 1997;15(16):1987-94.
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1997: Vallone D; Battista S; Pierantoni G M; Fedele M; Casalino L; Santoro M; Viglietto G; Fusco A; Verde P
Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product.
The EMBO journal 1997;16(17):5310-21.
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1997: Zhang L; Martelli M L; Battaglia C; Trapasso F; Tramontano D; Viglietto G; Porcellini A; Santoro M; Fusco A
Thyroid cell transformation inhibits the expression of a novel rat protein tyrosine phosphatase.
Experimental cell research 1997;235(1):62-70.
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1997: Santoro M; Santoro A; Maiorino L; Di Buono E; Quarto G; Forestieri P
Medulloblastoma in an adult: case report.
Journal of chemotherapy (Florence, Italy) 1997;9(2):161.
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1997: Gattei V; Celetti A; Cerrato A; Degan M; De Iuliis A; Rossi F M; Chiappetta G; Consales C; Improta S; Zagonel V; Aldinucci D; Agosti V; Santoro M; Vecchio G; Pinto A; Grieco M
Expression of the RET receptor tyrosine kinase and GDNFR-alpha in normal and leukemic human hematopoietic cells and stromal cells of the bone marrow microenvironment.
Blood 1997;89(8):2925-37.
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1997: Cirafici A M; Salvatore G; De Vita G; Carlomagno F; Dathan N A; Visconti R; Melillo R M; Fusco A; Santoro M
Only the substitution of methionine 918 with a threonine and not with other residues activates RET transforming potential.
Endocrinology 1997;138(4):1450-5.
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1997: Carlomagno F; Salvatore G; Cirafici A M; De Vita G; Melillo R M; de Franciscis V; Billaud M; Fusco A; Santoro M
The different RET-activating capability of mutations of cysteine 620 or cysteine 634 correlates with the multiple endocrine neoplasia type 2 disease phenotype.
Cancer research 1997;57(3):391-5.
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1997: Wirtschafter A; Schmidt R; Rosen D; Kundu N; Santoro M; Fusco A; Multhaupt H; Atkins J P; Rosen M R; Keane W M; Rothstein J L
Expression of the RET/PTC fusion gene as a marker for papillary carcinoma in Hashimoto's thyroiditis.
The Laryngoscope 1997;107(1):95-100.
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1996: Chiappetta G; Avantaggiato V; Visconti R; Fedele M; Battista S; Trapasso F; Merciai B M; Fidanza V; Giancotti V; Santoro M; Simeone A; Fusco A
High level expression of the HMGI (Y) gene during embryonic development.
Oncogene 1996;13(11):2439-46.
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1996: Portella G; Salvatore D; Botti G; Cerrato A; Zhang L; Mineo A; Chiappetta G; Santelli G; Pozzi L; Vecchio G; Fusco A; Santoro M
Development of mammary and cutaneous gland tumors in transgenic mice carrying the RET/PTC1 oncogene.
Oncogene 1996;13(9):2021-6.
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1996: Rizzo C; Califano D; Colucci-D'Amato G L; De Vita G; D'Alessio A; Dathan N A; Fusco A; Monaco C; Santelli G; Vecchio G; Santoro M; de Franciscis V
Ligand stimulation of a Ret chimeric receptor carrying the activating mutation responsible for the multiple endocrine neoplasia type 2B.
The Journal of biological chemistry 1996;271(46):29497-501.
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1996: Colucci-D'Amato G L; D'Alessio A; Filliatreau G; Florio T; Di Giamberardino L; Chiappetta G; Vecchio G; Fusco A; Santoro M; de Franciscis V
Presence of physiologically stimulated RET in adult rat brain: induction of RET expression during nerve regeneration.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(8):1081-6.
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1996: Califano D; D'Alessio A; Colucci-D'Amato G L; De Vita G; Monaco C; Santelli G; Di Fiore P P; Vecchio G; Fusco A; Santoro M; de Franciscis V
A potential pathogenetic mechanism for multiple endocrine neoplasia type 2 syndromes involves ret-induced impairment of terminal differentiation of neuroepithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7933-7.
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1996: Carlomagno F; De Vita G; Berlingieri M T; de Franciscis V; Melillo R M; Colantuoni V; Kraus M H; Di Fiore P P; Fusco A; Santoro M
Molecular heterogeneity of RET loss of function in Hirschsprung's disease.
The EMBO journal 1996;15(11):2717-25.
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1996: Santoro M; Chiappetta G; Cerrato A; Salvatore D; Zhang L; Manzo G; Picone A; Portella G; Santelli G; Vecchio G; Fusco A
Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice.
Oncogene 1996;12(8):1821-6.
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1996: Fedele M; Bandiera A; Chiappetta G; Battista S; Viglietto G; Manfioletti G; Casamassimi A; Santoro M; Giancotti V; Fusco A
Human colorectal carcinomas express high levels of high mobility group HMGI(Y) proteins.
Cancer research 1996;56(8):1896-901.
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1996: Salvatore D; Celetti A; Fabien N; Paulin C; Martelli M L; Battaglia C; Califano D; Monaco C; Viglietto G; Santoro M; Fusco A
Low frequency of p53 mutations in human thyroid tumours; p53 and Ras mutation in two out of fifty-six thyroid tumours.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(2):177-83.
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1996: Cerutti J; Trapasso F; Battaglia C; Zhang L; Martelli M L; Visconti R; Berlingieri M T; Fagin J A; Santoro M; Fusco A
Block of c-myc expression by antisense oligonucleotides inhibits proliferation of human thyroid carcinoma cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(1):119-26.
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1995: D'Alessio A; De Vita G; Calì G; Nitsch L; Fusco A; Vecchio G; Santelli G; Santoro M; de Franciscis V
Expression of the RET oncogene induces differentiation of SK-N-BE neuroblastoma cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(11):1387-94.
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1995: Santoro M; Grieco M; Melillo R M; Fusco A; Vecchio G
Molecular defects in thyroid carcinomas: role of the RET oncogene in thyroid neoplastic transformation.
European journal of endocrinology / European Federation of Endocrine Societies 1995;133(5):513-22.
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1995: Battista S; Martelli M L; Fedele M; Chiappetta G; Trapasso F; De Vita G; Battaglia C; Santoro M; Viglietto G; Fagin J A
A mutated p53 gene alters thyroid cell differentiation.
Oncogene 1995;11(10):2029-37.
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1995: Viglietto G; Chiappetta G; Martinez-Tello F J; Fukunaga F H; Tallini G; Rigopoulou D; Visconti R; Mastro A; Santoro M; Fusco A
RET/PTC oncogene activation is an early event in thyroid carcinogenesis.
Oncogene 1995;11(6):1207-10.
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1995: Califano D; Monaco C; de Vita G; D'Alessio A; Dathan N A; Possenti R; Vecchio G; Fusco A; Santoro M; de Franciscis V
Activated RET/PTC oncogene elicits immediate early and delayed response genes in PC12 cells.
Oncogene 1995;11(1):107-12.
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1995: Chiappetta G; Bandiera A; Berlingieri M T; Visconti R; Manfioletti G; Battista S; Martinez-Tello F J; Santoro M; Giancotti V; Fusco A
The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias.
Oncogene 1995;10(7):1307-14.
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1995: Berlingieri M T; Manfioletti G; Santoro M; Bandiera A; Visconti R; Giancotti V; Fusco A
Inhibition of HMGI-C protein synthesis suppresses retrovirally induced neoplastic transformation of rat thyroid cells.
Molecular and cellular biology 1995;15(3):1545-53.
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1995: Carlomagno F; Salvatore D; Santoro M; de Franciscis V; Quadro L; Panariello L; Colantuoni V; Fusco A
Point mutation of the RET proto-oncogene in the TT human medullary thyroid carcinoma cell line.
Biochemical and biophysical research communications 1995;207(3):1022-8.
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1995: Fusco A; Santoro M; Grieco M; Carlomagno F; Dathan N; Fabien N; Berlingieri M T; Li Z; De Franciscis V; Salvatore D
RET/PTC activation in human thyroid carcinomas.
Journal of endocrinological investigation 1995;18(2):127-9.
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1995: Santoro M; Carlomagno F; Romano A; Bottaro D P; Dathan N A; Grieco M; Fusco A; Vecchio G; Matoskova B; Kraus M H
Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B.
Science (New York, N.Y.) 1995;267(5196):381-3.
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1995: Bova R; Cascino A; Cipollaro M; Gargano S; Grau O; Micheli M R; Santoro M; Scarlato V; Storlazzi A
Bacteriophage T4 gene 28.
DNA sequence : the journal of DNA sequencing and mapping 1995;5(3):199-201.
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1994: Romano A; Wong W T; Santoro M; Wirth P J; Thorgeirsson S S; Di Fiore P P
The high transforming potency of erbB-2 and ret is associated with phosphorylation of paxillin and a 23 kDa protein.
Oncogene 1994;9(10):2923-33.
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1994: Grieco M; Cerrato A; Santoro M; Fusco A; Melillo R M; Vecchio G
Cloning and characterization of H4 (D10S170), a gene involved in RET rearrangements in vivo.
Oncogene 1994;9(9):2531-5.
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1994: Santoro M; Battaglia C; Zhang L; Carlomagno F; Martelli M L; Salvatore D; Fusco A
Cloning of the rat tissue inhibitor of metalloproteinases type 2 (TIMP-2) gene: analysis of its expression in normal and transformed thyroid cells.
Experimental cell research 1994;213(2):398-403.
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1994: Bongarzone I; Butti M G; Coronelli S; Borrello M G; Santoro M; Mondellini P; Pilotti S; Fusco A; Della Porta G; Pierotti M A
Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas.
Cancer research 1994;54(11):2979-85.
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1994: Fabien N; Fusco A; Santoro M; Barbier Y; Dubois P M; Paulin C
Description of a human papillary thyroid carcinoma cell line. Morphologic study and expression of tumoral markers.
Cancer 1994;73(8):2206-12.
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1994: Avantaggiato V; Dathan N A; Grieco M; Fabien N; Lazzaro D; Fusco A; Simeone A; Santoro M
Developmental expression of the RET protooncogene.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(3):305-11.
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1994: Santoro M; Dathan N A; Berlingieri M T; Bongarzone I; Paulin C; Grieco M; Pierotti M A; Vecchio G; Fusco A
Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma.
Oncogene 1994;9(2):509-16.
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1994: Santoro M; Wong W T; Aroca P; Santos E; Matoskova B; Grieco M; Fusco A; di Fiore P P
An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway.
Molecular and cellular biology 1994;14(1):663-75.
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1993: Santoro M; Sabino N; Ishizaka Y; Ushijima T; Carlomagno F; Cerrato A; Grieco M; Battaglia C; Martelli M L; Paulin C
Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours.
British journal of cancer 1993;68(3):460-4.
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1993: Santoro M; Melillo R M; Grieco M; Berlingieri M T; Vecchio G; Fusco A
The TRK and RET tyrosine kinase oncogenes cooperate with ras in the neoplastic transformation of a rat thyroid epithelial cell line.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(2):77-84.
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1993: Berlingieri M T; Santoro M; Battaglia C; Grieco M; Fusco A
The Adenovirus E1A gene blocks the differentiation of a thyroid epithelial cell line, however the neoplastic phenotype is achieved only after cooperation with other oncogenes.
Oncogene 1993;8(2):249-55.
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1992: Fabien N; Paulin C; Santoro M; Berger N; Grieco M; Galvain D; Barbier Y; Dubois P M; Fusco A
Detection of RET oncogene activation in human papillary thyroid carcinomas by in situ hybridisation.
British journal of cancer 1992;66(6):1094-8.
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1992: Santoro M; Carlomagno F; Hay I D; Herrmann M A; Grieco M; Melillo R; Pierotti M A; Bongarzone I; Della Porta G; Berger N
Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype.
The Journal of clinical investigation 1992;89(5):1517-22.
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1992: Pierotti M A; Santoro M; Jenkins R B; Sozzi G; Bongarzone I; Grieco M; Monzini N; Miozzo M; Herrmann M A; Fusco A
Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1616-20.
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1991: Sozzi G; Pierotti M A; Miozzo M; Donghi R; Radice P; De Benedetti V; Grieco M; Santoro M; Fusco A; Vecchio G
Refined localization to contiguous regions on chromosome 10q of the two genes (H4 and RET) that form the oncogenic sequence PTC.
Oncogene 1991;6(2):339-42.
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1990: Santoro M; Rosati R; Grieco M; Berlingieri M T; D'Amato G L; de Franciscis V; Fusco A
The ret proto-oncogene is consistently expressed in human pheochromocytomas and thyroid medullary carcinomas.
Oncogene 1990;5(10):1595-8.
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1990: Bova R; Cascino A; Cipollaro M; Grau O; Micheli M R; Santoro M; Storlazzi A; Scarlato V; Gargano S
Bacteriophage T4 gene 27.
Nucleic acids research 1990;18(10):3046.
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1990: Grieco M; Santoro M; Berlingieri M T; Melillo R M; Donghi R; Bongarzone I; Pierotti M A; Della Porta G; Fusco A; Vecchio G
PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas.
Cell 1990;60(4):557-63.
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1989: Bongarzone I; Pierotti M A; Monzini N; Mondellini P; Manenti G; Donghi R; Pilotti S; Grieco M; Santoro M; Fusco A
High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinoma.
Oncogene 1989;4(12):1457-62.
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1989: Donghi R; Sozzi G; Pierotti M A; Biunno I; Miozzo M; Fusco A; Grieco M; Santoro M; Vecchio G; Spurr N K
The oncogene associated with human papillary thyroid carcinoma (PTC) is assigned to chromosome 10 q11-q12 in the same region as multiple endocrine neoplasia type 2A (MEN2A).
Oncogene 1989;4(4):521-3.
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1989: Portella G; Ferulano G; Santoro M; Grieco M; Fusco A; Vecchio G
The Kirsten murine sarcoma virus induces rat thyroid carcinomas in vivo.
Oncogene 1989;4(2):181-8.
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1988: Santoro M; Scarlato V; Franzé A; Grau O; Cipollaro M; Gargano S; Bova R; Micheli M R; Storlazzi A; Cascino A
Symmetric transcription of bacteriophage T4 base plate genes.
Gene 1988;72(1-2):241-5.
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1988: Radice P; Donghi R; Pierotti M A; Longoni A; Fusco A; Grieco M; Santoro M; Vecchio G; Della Porta G
RFLP for TaqI of the human thyroid papillary carcinoma (PTC) oncogene.
Nucleic acids research 1988;16(18):9062.
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1988: Berlingieri M T; Portella G; Grieco M; Santoro M; Fusco A
Cooperation between the polyomavirus middle-T-antigen gene and the human c-myc oncogene in a rat thyroid epithelial differentiated cell line: model of in vitro progression.
Molecular and cellular biology 1988;8(5):2261-6.
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1988: Grieco M; Santoro M; Berlingieri M T; Donghi R; Pierotti M A; Della Porta G; Fusco A; Vecchio G
Molecular cloning of PTC, a new oncogene found activated in human thyroid papillary carcinomas and their lymph node metastases.
Annals of the New York Academy of Sciences 1988;551():380-1.
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