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Helena Santos

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Pedro Lamosa; Christopher Maycock; Neil D H Raven; Marta V Rodrigues; Jean Carr; Luís Gonçalves; Rita Ventura; Helena Santos
Organic solutes in the deepest phylogenetic branches of the Bacteria: identification of α(1-6)glucosyl-α(1-2)glucosylglycerate in Persephonella marina.
Przemyslaw Nogly; Helena Santos; Rute Castro; Matteo de Rosa; Ana Rute Neves; Margarida Archer
Production and crystallization of α-phosphoglucomutase from Lactococcus lactis.
Tiago M Pais; Pedro Lamosa; Manolis Matzapetakis; David L Turner; Helena Santos
Mannosylglycerate stabilizes staphylococcal nuclease with restriction of slow β-sheet motions.

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All Publications

2013: Pedro Lamosa; Christopher Maycock; Neil D H Raven; Marta V Rodrigues; Jean Carr; Luís Gonçalves; Rita Ventura; Helena Santos
Organic solutes in the deepest phylogenetic branches of the Bacteria: identification of α(1-6)glucosyl-α(1-2)glucosylglycerate in Persephonella marina.
Extremophiles : life under extreme conditions 2013;17(1):137-46.
2012: Przemyslaw Nogly; Helena Santos; Rute Castro; Matteo de Rosa; Ana Rute Neves; Margarida Archer
Production and crystallization of α-phosphoglucomutase from Lactococcus lactis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 9):1113-5.
2012: Tiago M Pais; Pedro Lamosa; Manolis Matzapetakis; David L Turner; Helena Santos
Mannosylglycerate stabilizes staphylococcal nuclease with restriction of slow β-sheet motions.
Protein science : a publication of the Protein Society 2012;21(8):1126-37.
2012: Luís Gonçalves; Nuno Borges; Hernán Dopazo; Pedro Fernandes; François Serra; Helena Santos
Evolution of the biosynthesis of di-myo-inositol phosphate, a marker of adaptation to hot marine environments.
Environmental microbiology 2012;14(3):691-701.
2012: Fernando M Pimentel-Santos; Patricia Pinto; Sara Rabiais; Célia Ribeiro; Helena Santos; Rui André Santos; Elsa Vieira-Sousa; Anabela Barcelos; Jaime C Branco; Matthew A Brown; José Costa; Margarida Cruz; Jorge Félix; João Eurico Fonseca; Fátima Godinho; Henrique Guedes-Pinto; Ana Filipa Mourão
Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts.
Clinical rheumatology 2012;31(3):447-54.
2012: Fernando Manuel Pimentel-Santos; Patricia Pinto; Ana Ribeiro; Helena Santos; H Trindade; Elsa Vieira de Sousa; Anabela Barcelos; Jaime Branco; Matthew A Brown; Margarida Cruz; João Eurico Fonseca; Fatima Godinho; Henrique Guedes-Pinto; D Ligeiro; Mafalda Matos; Ana Filipa Mourão
ANKH and susceptibility to and severity of ankylosing spondylitis.
The Journal of rheumatology 2012;39(1):131-4.
2011: Susana Gonçalves; Nuno Borges; Ana M Esteves; Helena Santos; Pedro M Matias
Three-dimensional structure of mannosyl-3-phosphoglycerate phosphatase from Thermus thermophilus HB27: a new member of the haloalcanoic acid dehalogenase superfamily.
Biochemistry 2011;50(44):9551-67.
2011: Paula Gaspar; Michael J Gasson; Ana Rute Neves; Claire Shearman; Helena Santos
High yields of 2,3-butanediol and mannitol in Lactococcus lactis through engineering of NAD⁺ cofactor recycling.
Applied and environmental microbiology 2011;77(19):6826-35.
2011: Helena Santos; C Tavares; Carole Kerdelhué; M R Paiva; M Branco
Temperature niche shift observed in a Lepidoptera population under allochronic divergence.
Journal of evolutionary biology 2011;24(9):1897-905.
2011: Pedro Lamosa; Ana Mingote; Helena Santos; Ksenia Egorova; Tatiana Groudieva; Dina Jabbour; Barbara Klippel; Garabed Antranikian
Gluconeotrehalose is the principal organic solute in the psychrotolerant bacterium Carnobacterium strain 17-4.
Extremophiles : life under extreme conditions 2011;15(4):463-72.
2011: Ana Lúcia Carvalho; Ana Rute Neves; Andreas Bohn; Filipa S Cardoso; Helena Santos
Engineering trehalose synthesis in Lactococcus lactis for improved stress tolerance.
Applied and environmental microbiology 2011;77(12):4189-99.
2011: Carla D Jorge; Rita Ventura; Christopher Maycock; Tiago F Outeiro; Helena Santos; Júlia Costa
Assessment of the efficacy of solutes from extremophiles on protein aggregation in cell models of Huntington's and Parkinson's diseases.
Neurochemical research 2011;36(6):1005-11.
2011: José A Brito; Nuno Borges; Clemens Vonrhein; Helena Santos; Margarida Archer
Crystal structure of Archaeoglobus fulgidus CTP:inositol-1-phosphate cytidylyltransferase, a key enzyme for di-myo-inositol-phosphate synthesis in (hyper)thermophiles.
Journal of bacteriology 2011;193(9):2177-85.
2011: Susana Gonçalves; Ana M Esteves; Nuno Borges; Helena Santos; Pedro M Matias
Crystallization and preliminary X-ray analysis of mannosyl-3-phosphoglycerate phosphatase from Thermus thermophilus HB27.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 3):390-6.
2011: Luis Fonseca; Claudia Sánchez; Helena Santos; Eberhard O Voit
Complex coordination of multi-scale cellular responses to environmental stress.
Molecular bioSystems 2011;7(3):731-41.
2011: Fernando M Pimentel-Santos; Patricia Pinto; Helena Santos; Anabela Barcelos; Jaime C Branco; Matthew A Brown; José Costa; Margarida Cruz; João Eurico Fonseca; Fátima Godinho; Henrique Guedes-Pinto; D Ligeiro; Mafalda Matos; Ana F Mourão; Gethin P Thomas
Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects.
Arthritis research & therapy 2011;13(2):R57.
2011: Helena Santos; C Burban; Jérôme Rousselet; J-P Rossi; M Branco; Carole Kerdelhué
Incipient allochronic speciation in the pine processionary moth (Thaumetopoea pityocampa, Lepidoptera, Notodontidae).
Journal of evolutionary biology 2011;24(1):146-58.
2010: José A Brito; Nuno Borges; Helena Santos; Margarida Archer
Production, crystallization and preliminary X-ray analysis of CTP:inositol-1-phosphate cytidylyltransferase from Archaeoglobus fulgidus.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 11):1463-5.
2010: Ana Rute Neves; Wietske A Pool; Ana Solopova; Jan Kok; Helena Santos; Oscar P Kuipers
Towards enhanced galactose utilization by Lactococcus lactis.
Applied and environmental microbiology 2010;76(21):7048-60.
2010: Tony Collins; Manolis Matzapetakis; Helena Santos
Backbone and side chain 1H, 15N and 13C assignments for a thiol-disulphide oxidoreductase from the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125.
Biomolecular NMR assignments 2010;4(2):151-4.
2010: Melinda Noronha; Hana Gerbelová; Tiago Q Faria; Daniel N Lund; D Alastair Smith; Helena Santos; António L Maçanita
Thermal unfolding kinetics of ubiquitin in the microsecond-to-second time range probed by Tyr-59 fluorescence.
The journal of physical chemistry. B 2010;114(30):9912-9.
2010: Susana Gonçalves; Nuno Borges; Ana M Esteves; Bruno L Victor; Cláudio M Soares; Helena Santos; Pedro M Matias
Structural analysis of Thermus thermophilus HB27 mannosyl-3-phosphoglycerate synthase provides evidence for a second catalytic metal ion and new insight into the retaining mechanism of glycosyltransferases.
The Journal of biological chemistry 2010;285(23):17857-68.
2010: Chantal Fernandes; Vitor Mendes; Joana Costa; Nuno Empadinhas; Carla Jorge; Pedro Lamosa; Helena Santos; Milton S da Costa
Two alternative pathways for the synthesis of the rare compatible solute mannosylglucosylglycerate in Petrotoga mobilis.
Journal of bacteriology 2010;192(6):1624-33.
2010: Nuno Borges; Rie Matsumi; Tadayuki Imanaka; Haruyuki Atomi; Helena Santos
Thermococcus kodakarensis mutants deficient in di-myo-inositol phosphate use aspartate to cope with heat stress.
Journal of bacteriology 2010;192(1):191-7.
2009: Tiago M Pais; Pedro Lamosa; Bertrand Garcia-Moreno; David L Turner; Helena Santos
Relationship between protein stabilization and protein rigidification induced by mannosylglycerate.
Journal of molecular biology 2009;394(2):237-50.
2009: Susana Gonçalves; Nuno Borges; Helena Santos; Pedro M Matias
Crystallization and preliminary X-ray analysis of mannosyl-3-phosphoglycerate synthase from Thermus thermophilus HB27.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 10):1014-7.
2009: Marta V Rodrigues; Nuno Borges; Carla P Almeida; Pedro Lamosa; Helena Santos
A unique beta-1,2-mannosyltransferase of Thermotoga maritima that uses di-myo-inositol phosphate as the mannosyl acceptor.
Journal of bacteriology 2009;191(19):6105-15.
2009: Melinda Noronha; Hana Gerbelová; Tiago Q Faria; Maria Manuel Sampaio; Rainer Rudolph; António L Maçanita; Helena Santos
Enhancing the fluorescence of tyr-59 in ubiquitin by blocking proton transfer.
Physical chemistry chemical physics : PCCP 2009;11(18):3580-3.
2009: Melinda Noronha; Raquel Santos; Emanuele Paci; Helena Santos; António L Maçanita
Fluorescence lifetimes of tyrosine residues in cytochrome c'' as local probes to study protein unfolding.
The journal of physical chemistry. B 2009;113(13):4466-74.
2009: Rute Castro; Ana Rute Neves; Luis Fonseca; Wietske A Pool; Jan Kok; Oscar P Kuipers; Helena Santos
Characterization of the individual glucose uptake systems of Lactococcus lactis: mannose-PTS, cellobiose-PTS and the novel GlcU permease.
Molecular microbiology 2009;71(3):795-806.
2009: Ann Zahle Andersen; Ana Lúcia Carvalho; Ana Rute Neves; Helena Santos; Ursula Kummer; Lars Folke Olsen
The metabolic pH response in Lactococcus lactis: an integrative experimental and modelling approach.
Computational biology and chemistry 2009;33(1):71-83.
2008: Tiago Q Faria; Ana Mingote; Filipa Siopa; Rita Ventura; Christopher D Maycock; Helena Santos
Design of new enzyme stabilizers inspired by glycosides of hyperthermophilic microorganisms.
Carbohydrate research 2008;343(18):3025-33.
2008: Luís Gonçalves; Pedro Lamosa; Robert Huber; Helena Santos
Di-myo-inositol phosphate and novel UDP-sugars accumulate in the extreme hyperthermophile Pyrolobus fumarii.
Extremophiles : life under extreme conditions 2008;12(3):383-9.
2008: César Fonseca; Ana Rute Neves; Alexandra M M Antunes; João Paulo Noronha; Bärbel Hahn-Hägerdal; Helena Santos; Isabel Spencer-Martins
Use of in vivo 13C nuclear magnetic resonance spectroscopy to elucidate L-arabinose metabolism in yeasts.
Applied and environmental microbiology 2008;74(6):1845-55.
2008: Carla D Jorge; Luis Fonseca; Winfried Boos; Helena Santos
Role of periplasmic trehalase in uptake of trehalose by the thermophilic bacterium Rhodothermus marinus.
Journal of bacteriology 2008;190(6):1871-8.
2008: Claudia Sánchez; Ana Rute Neves; João Cavalheiro; Margarida Moreira dos Santos; Nieves García-Quintáns; Paloma López; Helena Santos
Contribution of citrate metabolism to the growth of Lactococcus lactis CRL264 at low pH.
Applied and environmental microbiology 2008;74(4):1136-44.
2007: Paula Gaspar; Ana Rute Neves; Claire Shearman; Michael J Gasson; António M Baptista; David L Turner; Cláudio M Soares; Helena Santos
The lactate dehydrogenases encoded by the ldh and ldhB genes in Lactococcus lactis exhibit distinct regulation and catalytic properties - comparative modeling to probe the molecular basis.
The FEBS journal 2007;274(22):5924-36.
2007: Paulo Lemos; Yu Dai; Zhiguo Yuan; Jurg Keller; Helena Santos; Maria A M Reis
Elucidation of metabolic pathways in glycogen-accumulating organisms with in vivo 13C nuclear magnetic resonance.
Environmental microbiology 2007;9(11):2694-706.
2007: Filipe Santos; José L Vera; Pedro Lamosa; Graciela Font de Valdez; WILLEM DE VOS; Helena Santos; Fernando Sesma; Jeroen Hugenholtz
Pseudovitamin B(12) is the corrinoid produced by Lactobacillus reuteri CRL1098 under anaerobic conditions.
FEBS letters 2007;581(25):4865-70.
2007: Nuno Empadinhas; Vítor Mendes; Catarina Simões; Maria S Santos; Ana Mingote; Pedro Lamosa; Helena Santos; Milton S da Costa
Organic solutes in Rubrobacter xylanophilus: the first example of di-myo-inositol-phosphate in a thermophile.
Extremophiles : life under extreme conditions 2007;11(5):667-73.
2007: Marta V Rodrigues; Nuno Borges; Mafalda Henriques; Pedro Lamosa; Rita Ventura; Chantal Fernandes; Nuno Empadinhas; Christopher Maycock; Milton S da Costa; Helena Santos
Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles.
Journal of bacteriology 2007;189(15):5405-12.
2007: Melinda Noronha; João Lima; Emanuele Paci; Helena Santos; António L Maçanita
Tracking local conformational changes of ribonuclease A using picosecond time-resolved fluorescence of the six tyrosine residues.
Biophysical journal 2007;92(12):4401-14.
2007: Carla D Jorge; Pedro Lamosa; Helena Santos
Alpha-D-mannopyranosyl-(1-->2)-alpha-D-glucopyranosyl-(1-->2)-glycerate in the thermophilic bacterium Petrotoga miotherma--structure, cellular content and function.
The FEBS journal 2007;274(12):3120-7.
2007: Helena Santos; Jérôme Rousselet; Emmanuelle Magnoux; Maria-Rosa Paiva; Manuela Branco; Carole Kerdelhué
Genetic isolation through time: allochronic differentiation of a phenologically atypical population of the pine processionary moth.
Proceedings. Biological sciences / The Royal Society 2007;274(1612):935-41.
2007: Filipa S Cardoso; Rute F Castro; Nuno Borges; Helena Santos
Biochemical and genetic characterization of the pathways for trehalose metabolism in Propionibacterium freudenreichii, and their role in stress response.
Microbiology (Reading, England) 2007;153(Pt 1):270-80.
2007: Carla D Jorge; Maria Manuel Sampaio; Gudmundur O Hreggvidsson; Jakob K Kristjánson; Helena Santos
A highly thermostable trehalase from the thermophilic bacterium Rhodothermus marinus.
Extremophiles : life under extreme conditions 2007;11(1):115-22.
2006: Nuno Borges; Luís Gonçalves; Marta V Rodrigues; Filipa Siopa; Rita Ventura; Christopher Maycock; Pedro Lamosa; Helena Santos
Biosynthetic pathways of inositol and glycerol phosphodiesters used by the hyperthermophile Archaeoglobus fulgidus in stress adaptation.
Journal of bacteriology 2006;188(23):8128-35.
2006: Ana Rute Neves; Wietske A Pool; Rute Castro; Ana Mingote; Filipe Santos; Jan Kok; Oscar P Kuipers; Helena Santos
The alpha-phosphoglucomutase of Lactococcus lactis is unrelated to the alpha-D-phosphohexomutase superfamily and is encoded by the essential gene pgmH.
The Journal of biological chemistry 2006;281(48):36864-73.
2006: Pedro Lamosa; Luís Gonçalves; Marta V Rodrigues; Lígia O. Martins; Neil D H Raven; Helena Santos
Occurrence of 1-glyceryl-1-myo-inosityl phosphate in hyperthermophiles.
Applied and environmental microbiology 2006;72(9):6169-73.
2006: Wietske A Pool; Ana Rute Neves; Jan Kok; Helena Santos; Oscar P Kuipers
Natural sweetening of food products by engineering Lactococcus lactis for glucose production.
Metabolic engineering 2006;8(5):456-64.
2006: Eberhard O Voit; J Almeida; Simeone Marino; Raman Lall; G Goel; Ana Rute Neves; Helena Santos
Regulation of glycolysis in Lactococcus lactis: an unfinished systems biological case study.
Systems biology 2006;153(4):286-98.
2006: Eberhard O Voit; Ana Rute Neves; Helena Santos
The intricate side of systems biology.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9452-7.
2006: Francisco Enguita; Ehmke Pohl; David L Turner; Helena Santos; Maria Arménia Carrondo
Structural evidence for a proton transfer pathway coupled with haem reduction of cytochrome c" from Methylophilus methylotrophus.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2006;11(2):189-96.
2006: Joana Costa; Nuno Empadinhas; Luís Gonçalves; Pedro Lamosa; Helena Santos; Milton S da Costa
Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii.
Journal of bacteriology 2006;188(3):1022-30.
2005: Clélia Neves; Milton S da Costa; Helena Santos
Compatible solutes of the hyperthermophile Palaeococcus ferrophilus: osmoadaptation and thermoadaptation in the order thermococcales.
Applied and environmental microbiology 2005;71(12):8091-8.
2005: Elsa Wiame; Pedro Lamosa; Helena Santos; Emile Van Schaftingen
Identification of glucoselysine-6-phosphate deglycase, an enzyme involved in the metabolism of the fructation product glucoselysine.
The Biochemical journal 2005;392(Pt 2):263-9.
2005: Luis Fonseca; Miguel A R Monteiro; Paula M Alves; Manuel J T Carrondo; Helena Santos
Cultures of rat astrocytes challenged with a steady supply of glutamate: new model to study flux distribution in the glutamate-glutamine cycle.
Glia 2005;51(4):286-96.
2005: Ana Rute Neves; Wietske A Pool; Jan Kok; Oscar P Kuipers; Helena Santos
Overview on sugar metabolism and its control in Lactococcus lactis - the input from in vivo NMR.
FEMS microbiology reviews 2005;29(3):531-54.
2005: Susana Alarico; Nuno Empadinhas; Catarina Simões; zelia Silva; Anke Henne; Ana Mingote; Helena Santos; Milton S da Costa
Distribution of genes for synthesis of trehalose and Mannosylglycerate in Thermus spp. and direct correlation of these genes with halotolerance.
Applied and environmental microbiology 2005;71(5):2460-6.
2005: Tiago M Pais; Pedro Lamosa; Wagner Dos Santos; Jean Legall; David L Turner; Helena Santos
Structural determinants of protein stabilization by solutes. The important of the hairpin loop in rubredoxins.
The FEBS journal 2005;272(4):999-1011.
2005: zelia Silva; Maria-Manuel Sampaio; Anke Henne; Alex Böhm; Ruben Gutzat; Winfried Boos; Milton S da Costa; Helena Santos
The high-affinity maltose/trehalose ABC transporter in the extremely thermophilic bacterium Thermus thermophilus HB27 also recognizes sucrose and palatinose.
Journal of bacteriology 2005;187(4):1210-8.
2004: Tiago Q Faria; João Lima; Margarida Bastos; António L Maçanita; Helena Santos
Protein stabilization by osmolytes from hyperthermophiles: effect of mannosylglycerate on the thermal unfolding of recombinant nuclease a from Staphylococcus aureus studied by picosecond time-resolved fluorescence and calorimetry.
The Journal of biological chemistry 2004;279(47):48680-91.
2004: Melinda Noronha; João Lima; Margarida Bastos; Helena Santos; António L Maçanita
Unfolding of ubiquitin studied by picosecond time-resolved fluorescence of the tyrosine residue.
Biophysical journal 2004;87(4):2609-20.
2004: Nuno Empadinhas; Luciana Albuquerque; Joana Costa; Stephen H Zinder; Manuel A S Santos; Helena Santos; Milton S da Costa
A gene from the mesophilic bacterium Dehalococcoides ethenogenes encodes a novel mannosylglycerate synthase.
Journal of bacteriology 2004;186(13):4075-84.
2004: Ana Ramos; Ana Rute Neves; Rita Ventura; Christopher Maycock; Paloma López; Helena Santos
Effect of pyruvate kinase overproduction on glucose metabolism of Lactococcus lactis.
Microbiology (Reading, England) 2004;150(Pt 4):1103-11.
2004: Nuno Borges; Joey D Marugg; Nuno Empadinhas; Milton S da Costa; Helena Santos
Specialized roles of the two pathways for the synthesis of mannosylglycerate in osmoadaptation and thermoadaptation of Rhodothermus marinus.
The Journal of biological chemistry 2004;279(11):9892-8.
2004: Paula Gaspar; Ana Rute Neves; Ana Ramos; Michael J Gasson; Claire Shearman; Helena Santos
Engineering Lactococcus lactis for production of mannitol: high yields from food-grade strains deficient in lactate dehydrogenase and the mannitol transport system.
Applied and environmental microbiology 2004;70(3):1466-74.
2004: Filipa S Cardoso; Paula Gaspar; Jeroen Hugenholtz; Ana Ramos; Helena Santos
Enhancement of trehalose production in dairy propionibacteria through manipulation of environmental conditions.
International journal of food microbiology 2004;91(2):195-204.
2003: Rozalyn M Anderson; Magda Latorre-Esteves; Ana Rute Neves; Siva Lavu; Oliver Medvedik; Christopher Taylor; Konrad T Howitz; Helena Santos; David A Sinclair
Yeast life-span extension by calorie restriction is independent of NAD fluctuation.
Science (New York, N.Y.) 2003;302(5653):2124-6.
2003: Pedro Lamosa; David L Turner; Rita Ventura; Christopher Maycock; Helena Santos
Protein stabilization by compatible solutes. Effect of diglycerol phosphate on the dynamics of Desulfovibrio gigas rubredoxin studied by NMR.
European journal of biochemistry / FEBS 2003;270(23):4606-14.
2003: Tiago Q Faria; Stefan Knapp; Rudolf Ladenstein; António L Maçanita; Helena Santos
Protein stabilisation by compatible solutes: effect of mannosylglycerate on unfolding thermodynamics and activity of ribonuclease A.
Chembiochem : a European journal of chemical biology 2003;4(8):734-41.
2003: Nuno Empadinhas; Luciana Albuquerque; Anke Henne; Helena Santos; Milton S da Costa
The bacterium Thermus thermophilus, like hyperthermophilic archaea, uses a two-step pathway for the synthesis of mannosylglycerate.
Applied and environmental microbiology 2003;69(6):3272-9.
2003: Paula Fareleira; Bruno S Santos; Célia António; Pedro Moradas-Ferreira; Jean Legall; António V Xavier; Helena Santos
Response of a strict anaerobe to oxygen: survival strategies in Desulfovibrio gigas.
Microbiology (Reading, England) 2003;149(Pt 6):1513-22.
2003: Francisco Enguita; Luisa Rodrigues; Margarida Archer; Larry Sieker; Artur Rodrigues; Ehmke Pohl; David L Turner; Helena Santos; Maria Arménia Carrondo
Crystallization and preliminary X-ray characterization of cytochrome c" from the obligate methylotroph Methylophilus methylotrophus.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 3):580-3.
2003: André Antunes; Wolfgang Eder; Paula Fareleira; Helena Santos; Robert Huber
Salinisphaera shabanensis gen. nov., sp. nov., a novel, moderately halophilic bacterium from the brine-seawater interface of the Shaban Deep, Red Sea.
Extremophiles : life under extreme conditions 2003;7(1):29-34.
2003: Luís Gonçalves; Robert Huber; Milton S da Costa; Helena Santos
A variant of the hyperthermophile Archaeoglobus fulgidus adapted to grow at high salinity.
FEMS microbiology letters 2003;218(2):239-44.
2003: Paulo Lemos; Luisa Serafim; Helena Santos; Maria A M Reis
Production of polyhydroxyalkanoates by a mixed culture in a sequencing batch reactor: the use of propionate as carbon source.
Communications in agricultural and applied biological sciences 2003;68(2 Pt A):109-14.
2003: Paulo Lemos; Luisa Serafim; Margarida M Santos; Maria A M Reis; Helena Santos
Metabolic pathway for propionate utilization by phosphorus-accumulating organisms in activated sludge: 13C labeling and in vivo nuclear magnetic resonance.
Applied and environmental microbiology 2003;69(1):241-51.
2003: Maria-Manuel Sampaio; Helena Santos; Winfried Boos
Synthesis of GDP-mannose and mannosylglycerate from labeled mannose by genetically engineered Escherichia coli without loss of specific isotopic enrichment.
Applied and environmental microbiology 2003;69(1):233-40.
2002: Ana Rute Neves; Ana Ramos; Helena Costa; Iris I Van Swam; Jeroen Hugenholtz; Michiel Kleerebezem; WILLEM DE VOS; Helena Santos
Effect of different NADH oxidase levels on glucose metabolism by Lactococcus lactis: kinetics of intracellular metabolite pools determined by in vivo nuclear magnetic resonance.
Applied and environmental microbiology 2002;68(12):6332-42.
2002: Ana Rute Neves; Ana Ramos; Claire Shearman; Michael J Gasson; Helena Santos
Catabolism of mannitol in Lactococcus lactis MG1363 and a mutant defective in lactate dehydrogenase.
Microbiology (Reading, England) 2002;148(Pt 11):3467-76.
2002: Helena Santos; Milton S da Costa
Compatible solutes of organisms that live in hot saline environments.
Environmental microbiology 2002;4(9):501-9.
2002: Luisa Serafim; Paulo Lemos; Caterina Levantesi; Valter Tandoi; Helena Santos; Maria A M Reis
Methods for detection and visualization of intracellular polymers stored by polyphosphate-accumulating microorganisms.
Journal of microbiological methods 2002;51(1):1-18.
2002: Ana Rute Neves; Rita Ventura; Nahla Mansour; Claire Shearman; Michael J Gasson; Christopher Maycock; Ana Ramos; Helena Santos
Is the glycolytic flux in Lactococcus lactis primarily controlled by the redox charge? Kinetics of NAD(+) and NADH pools determined in vivo by 13C NMR.
The Journal of biological chemistry 2002;277(31):28088-98.
2002: Ana Ramos; Ana Rute Neves; Helena Santos
Metabolism of lactic acid bacteria studied by nuclear magnetic resonance.
Antonie van Leeuwenhoek 2002;82(1-4):249-61.
2002: Nuno Borges; Ana Ramos; Neil D H Raven; Richard J Sharp; Helena Santos
Comparative study of the thermostabilizing properties of mannosylglycerate and other compatible solutes on model enzymes.
Extremophiles : life under extreme conditions 2002;6(3):209-16.
2002: Alexandre Antunes; Fred A Rainey; M Fernanda Nobre; Peter Schumann; Ana Margarida Ferreira; Ana Ramos; Helena Santos; Costa Milton S da
Leuconostoc ficulneum sp. nov., a novel lactic acid bacterium isolated from a ripe fig, and reclassification of Lactobacillus fructosus as Leuconostoc fructosum comb. nov.
International journal of systematic and evolutionary microbiology 2002;52(Pt 2):647-55.
2001: Luis Fonseca; Paula M Alves; Manuel J T Carrondo; Helena Santos
Effect of ethanol on the metabolism of primary astrocytes studied by (13)C- and (31)P-NMR spectroscopy.
Journal of neuroscience research 2001;66(5):803-11.
2001: Alexandra M C R Alves; Gert-Jan W Euverink; Helena Santos; Lubbert Dijkhuizen
Different physiological roles of ATP- and PP(i)-dependent phosphofructokinase isoenzymes in the methylotrophic actinomycete Amycolatopsis methanolica.
Journal of bacteriology 2001;183(24):7231-40.
2001: Nuno Empadinhas; Joey D Marugg; Nuno Borges; Helena Santos; Milton S da Costa
Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes.
The Journal of biological chemistry 2001;276(47):43580-8.
2001: Pedro Lamosa; L Brennan; H Vis; David L Turner; Helena Santos
NMR structure of Desulfovibrio gigas rubredoxin: a model for studying protein stabilization by compatible solutes.
Extremophiles : life under extreme conditions 2001;5(5):303-11.
2001: L Brennan; David L Turner; Paula Fareleira; Helena Santos
Solution structure of Methylophilus methylotrophus cytochrome c": insights into the structural basis of haem-ligand detachment.
Journal of molecular biology 2001;308(2):353-65.
2001: Helena Santos; Milton S da Costa
Organic solutes from thermophiles and hyperthermophiles.
Methods in enzymology 2001;334():302-15.
2001: Ana Ramos; I C Boels; WILLEM DE VOS; Helena Santos
Relationship between glycolysis and exopolysaccharide biosynthesis in Lactococcus lactis.
Applied and environmental microbiology 2001;67(1):33-41.
2000: Paula M Alves; Luis Fonseca; Cristina C Peixoto; A C Almeida; Manuel J T Carrondo; Helena Santos
NMR studies on energy metabolism of immobilized primary neurons and astrocytes during hypoxia, ischemia and hypoglycemia.
NMR in biomedicine 2000;13(8):438-48.
2000: Nicholas J Price; L Brennan; Tiago Q Faria; Erik Vijgenboom; Gerard W Canters; David L Turner; Helena Santos
High yield of Methylophilus methylotrophus cytochrome c by coexpression with cytochrome c maturation gene cluster from Escherichia coli.
Protein expression and purification 2000;20(3):444-50.
2000: Ghislain Delpierre; Mark H Rider; François Collard; Vincent Stroobant; Florent Vanstapel; Helena Santos; Emile Van Schaftingen
Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase.
Diabetes 2000;49(10):1627-34.
2000: Paula M Alves; R Nunes; C Zhang; Christopher Maycock; U Sonnewald; Manuel J T Carrondo; Helena Santos
Metabolism of 3-(13)C-malate in primary cultures of mouse astrocytes.
Developmental neuroscience 2000;22(5-6):456-62.
2000: KB Xavier; Milton S da Costa; Helena Santos
Demonstration of a novel glycolytic pathway in the hyperthermophilic archaeon Thermococcus zilligii by (13)C-labeling experiments and nuclear magnetic resonance analysis.
Journal of bacteriology 2000;182(16):4632-6.
2000: Ana Rute Neves; Ana Ramos; Claire Shearman; Michael J Gasson; Jonas Almeida; Helena Santos
Metabolic characterization of Lactococcus lactis deficient in lactate dehydrogenase using in vivo 13C-NMR.
European journal of biochemistry / FEBS 2000;267(12):3859-68.
2000: Pedro Lamosa; A Burke; Ralf Peist; Robert Huber; Ming Y Liu; G Silva; Claudina Rodrigues-Pousada; Jean Legall; Christopher Maycock; Helena Santos
Thermostabilization of proteins by diglycerol phosphate, a new compatible solute from the hyperthermophile Archaeoglobus fulgidus.
Applied and environmental microbiology 2000;66(5):1974-9.
2000: L Brennan; David L Turner; Ana C Messias; M L Teodoro; Jean Legall; Helena Santos; António V Xavier
Structural basis for the network of functional cooperativities in cytochrome c(3) from Desulfovibrio gigas: solution structures of the oxidised and reduced states.
Journal of molecular biology 2000;298(1):61-82.
1999: Lígia O. Martins; Nuno Empadinhas; Joey D Marugg; C Miguel; C Ferreira; Milton S da Costa; Helena Santos
Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase.
The Journal of biological chemistry 1999;274(50):35407-14.
1999: Pedro E Cruz; P C Martins; Paula M Alves; Cristina C Peixoto; Helena Santos; JL Moreira; Manuel J T Carrondo
Proteolytic activity in infected and noninfected insect cells: degradation of HIV-1 Pr55gag particles.
Biotechnology and bioengineering 1999;65(2):133-43.
1999: Nicholas J Price; Erik Vijgenboom; G Ribeiro; JV Costa; Gerard W Canters; Helena Santos
Cloning and sequence analysis of the gene encoding Methylophilus methylotrophus cytochrome c", a unique protein with a perpendicular orientation of the histidinyl ligands.
Biochimica et biophysica acta 1999;1413(1):55-61.
1999: David L Turner; L Brennan; Helmut E Meyer; Christiane Lohaus; C Siethoff; H S Costa; B Gonzalez; Helena Santos; J E Suárez
Solution structure of plantaricin C, a novel lantibiotic.
European journal of biochemistry / FEBS 1999;264(3):833-9.
1999: M M Santos; Paulo Lemos; Maria A M Reis; Helena Santos
Glucose metabolism and kinetics of phosphorus removal by the fermentative bacterium Microlunatus phosphovorus.
Applied and environmental microbiology 1999;65(9):3920-8.
1999: Ana Rute Neves; Ana Ramos; M C Nunes; Michiel Kleerebezem; Jeroen Hugenholtz; WILLEM DE VOS; J Almeida; Helena Santos
In vivo nuclear magnetic resonance studies of glycolytic kinetics in Lactococcus lactis.
Biotechnology and bioengineering 1999;64(2):200-12.
1999: KB Xavier; Ralf Peist; M Kossmann; Winfried Boos; Helena Santos
Maltose metabolism in the hyperthermophilic archaeon Thermococcus litoralis: purification and characterization of key enzymes.
Journal of bacteriology 1999;181(11):3358-67.
1999: zelia Silva; Nuno Borges; Lígia O. Martins; R Wait; Milton S da Costa; Helena Santos
Combined effect of the growth temperature and salinity of the medium on the accumulation of compatible solutes by Rhodothermus marinus and Rhodothermus obamensis.
Extremophiles : life under extreme conditions 1999;3(2):163-72.
1998: Ana C Messias; D H Kastrau; H S Costa; Jean Legall; David L Turner; Helena Santos; António V Xavier
Solution structure of Desulfovibrio vulgaris (Hildenborough) ferrocytochrome c3: structural basis for functional cooperativity.
Journal of molecular biology 1998;281(4):719-39.
1998: Reinhold Horlacher; KB Xavier; Helena Santos; Jocelyne DiRuggiero; M Kossmann; Winfried Boos
Archaeal binding protein-dependent ABC transporter: molecular and biochemical analysis of the trehalose/maltose transport system of the hyperthermophilic archaeon Thermococcus litoralis.
Journal of bacteriology 1998;180(3):680-9.
1998: Milton S da Costa; Helena Santos; E A Galinski
An overview of the role and diversity of compatible solutes in Bacteria and Archaea.
Advances in biochemical engineering/biotechnology 1998;61():117-53.
1997: M Miranda; A Ramos; M Veiga-da-Cunha; M C Loureiro-Dias; Helena Santos
Biochemical basis for glucose-induced inhibition of malolactic fermentation in Leuconostoc oenos.
Journal of bacteriology 1997;179(17):5347-54.
1997: Paula Fareleira; Jean Legall; António V Xavier; Helena Santos
Pathways for utilization of carbon reserves in Desulfovibrio gigas under fermentative and respiratory conditions.
Journal of bacteriology 1997;179(12):3972-80.
1996: W F Sijbesma; Jonas Almeida; Maria A M Reis; Helena Santos
Uncoupling effect of nitrite during denitrification by Pseudomonas fluorescens: An in vivo (31)P-NMR study.
Biotechnology and bioengineering 1996;52(1):176-82.
1996: Lígia O. Martins; L S Carreto; Milton S da Costa; Helena Santos
New compatible solutes related to Di-myo-inositol-phosphate in members of the order Thermotogales.
Journal of bacteriology 1996;178(19):5644-51.
1996: K B Xavier; Lígia O. Martins; Ralf Peist; M Kossmann; Winfried Boos; Helena Santos
High-affinity maltose/trehalose transport system in the hyperthermophilic archaeon Thermococcus litoralis.
Journal of bacteriology 1996;178(16):4773-7.
1996: P M Alves; U Flögel; A Brand; Dieter Leibfritz; Manuel J T Carrondo; Helena Santos; U Sonnewald
Immobilization of primary astrocytes and neurons for online monitoring of biochemical processes by NMR.
Developmental neuroscience 1996;18(5-6):478-83.
1995: K B Xavier; M Kossmann; Helena Santos; Winfried Boos
Kinetic analysis by in vivo 31P nuclear magnetic resonance of internal Pi during the uptake of sn-glycerol-3-phosphate by the pho regulon-dependent Ugp system and the glp regulon-dependent GlpT system.
Journal of bacteriology 1995;177(3):699-704.
1994: H S Costa; Helena Santos; David L Turner
An unusual conformation of the methionine haem ligand in cytochrome cL established by two-dimensional 1H-NMR.
European journal of biochemistry / FEBS 1994;223(3):783-9.
1994: A Ramos; K N Jordan; T M Cogan; Helena Santos
C Nuclear Magnetic Resonance Studies of Citrate and Glucose Cometabolism by Lactococcus lactis.
Applied and environmental microbiology 1994;60(6):1739-48.
1993: Helena Santos; P Fareleira; António V Xavier; L Chen; Ming Y Liu; Jean Legall
Aerobic metabolism of carbon reserves by the "obligate anaerobe" Desulfovibrio gigas.
Biochemical and biophysical research communications 1993;195(2):551-7.
1993: L Chen; Ming Y Liu; Jean Legall; P Fareleira; Helena Santos; António V Xavier
Purification and characterization of an NADH-rubredoxin oxidoreductase involved in the utilization of oxygen by Desulfovibrio gigas.
European journal of biochemistry / FEBS 1993;216(2):443-8.
1993: H S Costa; Helena Santos; David L Turner
Characterization of the haem environment in Methylophilus methylotrophus ferricytochrome c" by 1H-NMR.
European journal of biochemistry / FEBS 1993;215(3):817-24.
1993: Maria Veiga-da-Cunha; Helena Santos; Emile Van Schaftingen
Pathway and regulation of erythritol formation in Leuconostoc oenos.
Journal of bacteriology 1993;175(13):3941-8.
1993: L Chen; Ming Y Liu; Jean Legall; P Fareleira; Helena Santos; António V Xavier
Rubredoxin oxidase, a new flavo-hemo-protein, is the site of oxygen reduction to water by the "strict anaerobe" Desulfovibrio gigas.
Biochemical and biophysical research communications 1993;193(1):100-5.
1993: Miguel Teixeira; A P Campos; A P Aguiar; H S Costa; Helena Santos; David L Turner; António V Xavier
Pitfalls in assigning heme axial coordination by EPR. c-Type cytochromes with atypical Met-His ligation.
FEBS letters 1993;317(3):233-6.
1992: Carlos A Salgueiro; David L Turner; Helena Santos; Jean Legall; António V Xavier
Assignment of the redox potentials to the four haems in Desulfovibrio vulgaris cytochrome c3 by 2D-NMR.
FEBS letters 1992;314(2):155-8.
1992: H S Costa; Helena Santos; David L Turner; António V Xavier
Involvement of a labile axial histidine in coupling electron and proton transfer in Methylophilus methylotrophus cytochrome c''.
European journal of biochemistry / FEBS 1992;208(2):427-33.
1992: David L Turner; Helena Santos; P Fareleira; Isabel Pacheco; Jean Legall; António V Xavier
Structure determination of a novel cyclic phosphocompound isolated from Desulfovibrio desulfuricans.
The Biochemical journal 1992;285 ( Pt 2)():387-90.
1992: Helena Santos; David L Turner
13C and proton NMR studies of horse cytochrome c. Systematic assignment of methyl and methine resonances in both oxidation states.
European journal of biochemistry / FEBS 1992;206(3):721-8.
1991: Helena Santos; P Fareleira; C Pedregal; Jean Legall; António V Xavier
In vivo 31P-NMR studies of Desulfovibrio species. Detection of a novel phosphorus-containing compound.
European journal of biochemistry / FEBS 1991;201(1):283-7.
1990: M C Loureiro-Dias; Helena Santos
Effects of ethanol on Saccharomyces cerevisiae as monitored by in vivo 31P and 13C nuclear magnetic resonance.
Archives of microbiology 1990;153(4):384-91.
1989: Helena Santos; P Fareleira; R Toci; Jean Legall; H D Peck; António V Xavier
In vivo 31P- and 13C-NMR studies of ATP synthesis and methane formation by Methanosarcina barkeri.
European journal of biochemistry / FEBS 1989;180(2):421-7.
1989: M C Loureiro-Dias; Helena Santos
Effects of 2-deoxyglucose on Saccharomyces cerevisiae as observed by in vivo 31P-NMR.
FEMS microbiology letters 1989;48(1):25-8.