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Manuela Santos

Research Profile

Chemicals & Drugs

Living Beings

Activities & Behaviors

Environmental Monitoring

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Portugal

Disorders

Anatomy

Livers

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Publications

TOP 3
Antonio Layoun; Manuela M Santos
Bacterial cell wall constituents induce hepcidin expression in macrophages through MyD88 signaling.
J Soares; L Filipe C Castro; Nuno Monteiro; Maria Armanda Reis-Henriques; Manuela M Santos
Zebrafish (Danio rerio) life-cycle exposure to chronic low doses of ethinylestradiol modulates p53 gene transcription within the gonads, but not NER pathways.
Teresa Neuparth; Susana M Moreira; Manuela M Santos; Maria Armanda Reis-Henriques
Review of oil and HNS accidental spills in Europe: identifying major environmental monitoring gaps and drawing priorities.

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All Publications

2012: Antonio Layoun; Manuela M Santos
Bacterial cell wall constituents induce hepcidin expression in macrophages through MyD88 signaling.
Inflammation 2012;35(4):1500-6.
2012: J Soares; L Filipe C Castro; Nuno Monteiro; Maria Armanda Reis-Henriques; Manuela M Santos
Zebrafish (Danio rerio) life-cycle exposure to chronic low doses of ethinylestradiol modulates p53 gene transcription within the gonads, but not NER pathways.
Ecotoxicology (London, England) 2012;21(5):1513-22.
2012: Teresa Neuparth; Susana M Moreira; Manuela M Santos; Maria Armanda Reis-Henriques
Review of oil and HNS accidental spills in Europe: identifying major environmental monitoring gaps and drawing priorities.
Marine pollution bulletin 2012;64(6):1085-95.
2011: M P Sárria; J Soares; Maria Natividade Vieira; L Filipe C Castro; Manuela M Santos; Nuno Monteiro
Rapid-behaviour responses as a reliable indicator of estrogenic chemical toxicity in zebrafish juveniles.
Chemosphere 2011;85(10):1543-7.
2011: M P Sárria; N Vieira; Maria Armanda Reis-Henriques; Manuela M Santos; Nuno Monteiro
Drifting towards the surface: a shift in newborn pipefish's vertical distribution when exposed to the synthetic steroid ethinylestradiol.
Chemosphere 2011;84(5):618-24.
2011: M P Sárria; Manuela M Santos; Maria Armanda Reis-Henriques; N Vieira; Nuno Monteiro
The unpredictable effects of mixtures of androgenic and estrogenic chemicals on fish early life.
Environment international 2011;37(2):418-24.
2011: Deolinda Lima; M A Reis-Henriques; R Silva; A I Santos; L Filipe C Castro; Manuela M Santos
Tributyltin-induced imposex in marine gastropods involves tissue-specific modulation of the retinoid X receptor.
Aquatic toxicology (Amsterdam, Netherlands) 2011;101(1):221-7.
2011: Teresa Neuparth; S Moreira; Manuela M Santos; Maria Armanda Reis-Henriques
Hazardous and Noxious Substances (HNS) in the marine environment: prioritizing HNS that pose major risk in a European context.
Marine pollution bulletin 2011;62(1):21-8.
2010: Manuela M Santos; M Solé; Deolinda Lima; B Hambach; A M Ferreira; Maria Armanda Reis-Henriques
Validating a multi-biomarker approach with the shanny Lipophrys pholis to monitor oil spills in European marine ecosystems.
Chemosphere 2010;81(6):685-91.
2009: J Soares; Ana Maria Coimbra; Maria Armanda Reis-Henriques; Nuno Monteiro; Maria Natividade Vieira; Jorge Oliveira; P Guedes-Dias; A Fontaínhas-Fernandes; S Silva Parra; Arsélio P Carvalho; L Filipe C Castro; Manuela M Santos
Disruption of zebrafish (Danio rerio) embryonic development after full life-cycle parental exposure to low levels of ethinylestradiol.
Aquatic toxicology (Amsterdam, Netherlands) 2009;95(4):330-8.
2009: Manuela M Santos; P Enes; Maria Armanda Reis-Henriques; J Kuballa; L Filipe C Castro; Maria Natividade Vieira
Organotin levels in seafood from Portuguese markets and the risk for consumers.
Chemosphere 2009;75(5):661-6.
2009: Hua Huang; Marco Constante; Antonio Layoun; Manuela M Santos
Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli.
Blood 2009;113(15):3593-9.
2009: Hua Huang; Shizuo Akira; Manuela M Santos
Is the iron donor lipocalin 2 implicated in the pathophysiology of hereditary hemochromatosis?
Hepatology (Baltimore, Md.) 2009;49(3):1012-6.
2008: Wenlei Jiang; Marco Constante; Manuela M Santos
Anemia upregulates lipocalin 2 in the liver and serum.
Blood cells, molecules & diseases 2008;41(2):169-74.
2008: Manuela M Santos; Maria Armanda Reis-Henriques; R Guillot; D Lima; R Franco-Duarte; I Mendes; S Queirós; L Filipe C Castro
Anti-androgenic effects of sewage treatment plant effluents in the prosobranch gastropod Nucella lapillus.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2008;148(1):87-93.
2008: D Lima; Manuela M Santos; A M Ferreira; C Micaelo; Maria Armanda Reis-Henriques
The use of the shanny Lipophrys pholis for pollution monitoring: a new sentinel species for the northwestern European marine ecosystems.
Environment international 2008;34(1):94-101.
2007: L Filipe C Castro; D Lima; A Machado; C Melo; Y Hiromori; J Nishikawa; T Nakanishi; Maria Armanda Reis-Henriques; Manuela M Santos
Imposex induction is mediated through the Retinoid X Receptor signalling pathway in the neogastropod Nucella lapillus.
Aquatic toxicology (Amsterdam, Netherlands) 2007;85(1):57-66.
2007: J Micael; Maria Armanda Reis-Henriques; A P Carvalho; Manuela M Santos
Genotoxic effects of binary mixtures of xenoandrogens (tributyltin, triphenyltin) and a xenoestrogen (ethinylestradiol) in a partial life-cycle test with Zebrafish (Danio rerio).
Environment international 2007;33(8):1035-9.
2007: L Filipe C Castro; C Melo; R Guillot; I Mendes; S Queirós; D Lima; Maria Armanda Reis-Henriques; Manuela M Santos
The estrogen receptor of the gastropod Nucella lapillus: modulation following exposure to an estrogenic effluent?
Aquatic toxicology (Amsterdam, Netherlands) 2007;84(4):465-8.
2007: Marco Constante; Dongmei Wang; Valérie-Ann Raymond; Marc Bilodeau; Manuela M Santos
Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha.
The American journal of pathology 2007;170(2):497-504.
2006: Marco Constante; Wenlei Jiang; Dongmei Wang; Valérie-Ann Raymond; Marc Bilodeau; Manuela M Santos
Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(2):G229-37.
2006: José Luis Gómez-Ariza; Manuela M Santos; Emilio Morales; Inmaculada Giráldez; Daniel Sánchez-Rodas; N Vieira; J F Kemp; Jan P Boon; Cato C Ten Hallers-Tjabbes
Organotin contamination in the Atlantic Ocean off the Iberian Peninsula in relation to shipping.
Chemosphere 2006;64(7):1100-8.
2006: P Rodrigues; Maria Armanda Reis-Henriques; J Campos; Manuela M Santos
Urogenital papilla feminization in male Pomatoschistus minutus from two estuaries in northwestern Iberian Peninsula.
Marine environmental research 2006;62 Suppl():S258-62.
2006: Manuela M Santos; Maria Armanda Reis-Henriques; Maria Natividade Vieira; Montserrat Solé
Triphenyltin and tributyltin, single and in combination, promote imposex in the gastropod Bolinus brandaris.
Ecotoxicology and environmental safety 2006;64(2):155-62.
2006: Giovanni Coppola; Sang-Hyun Choi; Manuela M Santos; Carlos Miranda; Dmitri Tentler; Eric Wexler; Massimo Pandolfo; Daniel Geschwind
Gene expression profiling in frataxin deficient mice: microarray evidence for significant expression changes without detectable neurodegeneration.
Neurobiology of disease 2006;22(2):302-11.
2006: Maria do Carmo Costa; Andreia Teixeira-Castro; Marco Constante; Marina Magalhães; Paula Magalhães; Joana Cerqueira; José Vale; Vitorina Passão; Célia Barbosa; Conceição Robalo; Paula Coutinho; José Barros; Manuela M Santos; Jorge Sequeiros; Patrícia Maciel
Exclusion of mutations in the PRNP, JPH3, TBP, ATN1, CREBBP, POU3F2 and FTL genes as a cause of disease in Portuguese patients with a Huntington-like phenotype.
Journal of human genetics 2006;51(8):645-51.
2006: Manuela M Santos; J Micael; A P Carvalho; R Morabito; Petra Booy; P Massanisso; Marja Lamoree; Maria Armanda Reis-Henriques
Estrogens counteract the masculinizing effect of tributyltin in zebrafish.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2006;142(1-2):151-5.
2005: Hortence Makui; Ricardo J Soares; Wenlei Jiang; Marco Constante; Manuela M Santos
Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading.
Blood 2005;106(6):2189-95.
2005: Patrícia Maciel; Vitor Tedim Cruz; Marco Constante; I Iniesta; Maria do Carmo Costa; S Gallati; Nuno Sousa; Jorge Sequeiros; Paula Coutinho; Manuela M Santos
Neuroferritinopathy: missense mutation in FTL causing early-onset bilateral pallidal involvement.
Neurology 2005;65(4):603-5.
2005: Manuela M Santos; L Filipe C Castro; Maria Natividade Vieira; J Micael; R Morabito; P Massanisso; Maria Armanda Reis-Henriques
New insights into the mechanism of imposex induction in the dogwhelk Nucella lapillus.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2005;141(1):101-9.
2005: L Filipe C Castro; Manuela M Santos; Maria Armanda Reis-Henriques
The genomic environment around the Aromatase gene: evolutionary insights.
BMC evolutionary biology 2005;5():43.
2004: Carlos Miranda; Manuela M Santos; Keiichi Ohshima; Marco Tessaro; Jorge Sequeiros; Massimo Pandolfo
Frataxin overexpressing mice.
FEBS letters 2004;572(1-3):281-8.
2004: Maria do Carmo Costa; Joana Gomes-da-Silva; Carlos Miranda; Jorge Sequeiros; Manuela M Santos; Patrícia Maciel
Genomic structure, promoter activity, and developmental expression of the mouse homologue of the Machado-Joseph disease (MJD) gene.
Genomics 2004;84(2):361-73.
2004: M Castro; Manuela M Santos; Nuno Monteiro; N Vieira
Measuring lysosomal stability as an effective tool for marine coastal environmental monitoring.
Marine environmental research 2004;58(2-5):741-5.
2004: Manuela M Santos; N Vieira; Maria Armanda Reis-Henriques; A M Santos; J L Gomez-Ariza; I Giraldez; Cato C Ten Hallers-Tjabbes
Imposex and butyltin contamination off the Oporto Coast (NW Portugal): a possible effect of the discharge of dredged material.
Environment international 2004;30(6):793-8.
2004: Carlos Miranda; Hortence Makui; Nancy C Andrews; Manuela M Santos
Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knock-out mice.
Blood 2004;103(7):2847-9.
2003: Carlos Miranda; Hortence Makui; Ricardo J Soares; Marc Bilodeau; Jeannie Mui; Hojatollah Vali; Richard Bertrand; Nancy C Andrews; Manuela M Santos
Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin.
Blood 2003;102(7):2574-80.
2003: Manuela M Santos; Carlos Miranda; Joanne E Levy; Lynne K Montross; Mireille Cossée; Jorge Sequeiros; Nancy Andrews; Michel Koenig; Massimo Pandolfo
Iron metabolism in mice with partial frataxin deficiency.
Cerebellum (London, England) 2003;2(2):146-53.
2002: Manuela M Santos; Cato C Ten Hallers-Tjabbes; N Vieira; Jan P Boon; C Porte
Cytochrome P450 differences in normal and imposex-affected female whelk Buccinum undatum from the open North Sea.
Marine environmental research 2002;54(3-5):661-5.
2002: Carlos Miranda; Manuela M Santos; Keiichi Ohshima; Julie Smith; Liangtao Li; Michaeline Bunting; Mireille Cossée; Michel Koenig; Jorge Sequeiros; Jerry Kaplan; Massimo Pandolfo
Frataxin knockin mouse.
FEBS letters 2002;512(1-3):291-7.
2001: Manuela M Santos; Keiichi Ohshima; Massimo Pandolfo
Frataxin deficiency enhances apoptosis in cells differentiating into neuroectoderm.
Human molecular genetics 2001;10(18):1935-44.