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Jan Sap

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Kinnosuke Yahiro; Junzo Hisatsune; Hajime Isomoto; Joel Moss; Masayuki Nakano; Masatoshi Noda; Fumio Nomura; Jan Sap; Mamoru Satoh; Hidekazu Suzuki; Toshiya Hirayama
Low-density lipoprotein receptor-related protein-1 (LRP1) mediates autophagy and apoptosis caused by Helicobacter pylori VacA.
Nagahide Takahashi; Hiroshi Ujike; Nathalie Vacaresse; Branko Aleksic; Joseph Buxbaum; Véronique Dubreuil; Masashi Ikeda; Nakao Iwata; Itaru Kushima; Naheed Mirza; Karin Sandager Nielsen; Norio Ozaki; Steffen Petersen; Takeshi Sakurai; Jan Sap
Loss of function studies in mice and genetic association link receptor protein tyrosine phosphatase α to schizophrenia.
Marli F Curcio; Wagner L Batista; Edlaine Linares; Fabio D Nascimento; Miriam S Moraes; Roberta E Borges; Jan Sap; Arnold Stern; Hugo P Monteiro
Regulatory effects of nitric oxide on Src kinase, FAK, p130Cas, and receptor protein tyrosine phosphatase alpha (PTP-alpha): a role for the cellular redox environment.

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All Publications

2012: Kinnosuke Yahiro; Junzo Hisatsune; Hajime Isomoto; Joel Moss; Masayuki Nakano; Masatoshi Noda; Fumio Nomura; Jan Sap; Mamoru Satoh; Hidekazu Suzuki; Toshiya Hirayama
Low-density lipoprotein receptor-related protein-1 (LRP1) mediates autophagy and apoptosis caused by Helicobacter pylori VacA.
The Journal of biological chemistry 2012;287(37):31104-15.
2011: Nagahide Takahashi; Hiroshi Ujike; Nathalie Vacaresse; Branko Aleksic; Joseph Buxbaum; Véronique Dubreuil; Masashi Ikeda; Nakao Iwata; Itaru Kushima; Naheed Mirza; Karin Sandager Nielsen; Norio Ozaki; Steffen Petersen; Takeshi Sakurai; Jan Sap
Loss of function studies in mice and genetic association link receptor protein tyrosine phosphatase α to schizophrenia.
Biological psychiatry 2011;70(7):626-35.
2010: Marli F Curcio; Wagner L Batista; Edlaine Linares; Fabio D Nascimento; Miriam S Moraes; Roberta E Borges; Jan Sap; Arnold Stern; Hugo P Monteiro
Regulatory effects of nitric oxide on Src kinase, FAK, p130Cas, and receptor protein tyrosine phosphatase alpha (PTP-alpha): a role for the cellular redox environment.
Antioxidants & redox signaling 2010;13(2):109-25.
2008: Junzo Hisatsune; Masaaki Nakayama; Hajime Isomoto; Hisao Kurazono; Naofumi Mukaida; Asish K Mukhopadhyay; Takeshi Azuma; Yoshio Yamaoka; Jan Sap; Eiki Yamasaki; Kinnosuke Yahiro; Joel Moss; Toshiya Hirayama
Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):5017-27.
2007: Ana Kostic; Jan Sap; Michael P Sheetz
RPTPalpha is required for rigidity-dependent inhibition of extension and differentiation of hippocampal neurons.
Journal of cell science 2007;120(Pt 21):3895-904.
2007: Junzo Hisatsune; Eiki Yamasaki; Masaaki Nakayama; Daisuke Shirasaka; Hisao Kurazono; Yohtaro Katagata; Hiroyasu Inoue; Jiahuai Han; Jan Sap; Kinnosuke Yahiro; Joel Moss; Toshiya Hirayama
Helicobacter pylori VacA enhances prostaglandin E2 production through induction of cyclooxygenase 2 expression via a p38 mitogen-activated protein kinase/activating transcription factor 2 cascade in AZ-521 cells.
Infection and immunity 2007;75(9):4472-81.
2006: Masaaki Nakayama; Junzo Hisatsune; Eiki Yamasaki; Yoshito Nishi; Akihiro Wada; Hisao Kurazono; Jan Sap; Kinnosuke Yahiro; Joel Moss; Toshiya Hirayama
Clustering of Helicobacter pylori VacA in lipid rafts, mediated by its receptor, receptor-like protein tyrosine phosphatase beta, is required for intoxication in AZ-521 Cells.
Infection and immunity 2006;74(12):6571-80.
2006: Zohar Tiran; Asher Peretz; Tal Sines; Vera Shinder; Jan Sap; Bernard Attali; Ari Elson
Tyrosine phosphatases epsilon and alpha perform specific and overlapping functions in regulation of voltage-gated potassium channels in Schwann cells.
Molecular biology of the cell 2006;17(10):4330-42.
2004: Kinnosuke Yahiro; Akihiro Wada; Eiki Yamasaki; Masaaki Nakayama; Yoshito Nishi; Junzo Hisatsune; Naoko Morinaga; Jan Sap; Masatoshi Noda; Joel Moss; Toshiya Hirayama
Essential domain of receptor tyrosine phosphatase beta (RPTPbeta) for interaction with Helicobacter pylori vacuolating cytotoxin.
The Journal of biological chemistry 2004;279(49):51013-21.
2003: Angiola Petrone; Fortunato Battaglia; Cheng Wang; Adina Dusa; Jing Su; David Zagzag; Riccardo Bianchi; Patrizia Casaccia-Bonnefil; Ottavio Arancio; Jan Sap
Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation.
The EMBO journal 2003;22(16):4121-31.
2003: Goetz von Wichert; Guoying Jiang; Ana Kostic; Kurt J De Vos; Jan Sap; Michael P Sheetz
RPTP-alpha acts as a transducer of mechanical force on alphav/beta3-integrin-cytoskeleton linkages.
The Journal of cell biology 2003;161(1):143-53.
2002: Huogen Lu; Poonam Shah; David Ennis; Gail Shinder; Jan Sap; Hoang Le-Tien; I George Fantus
The differentiation of skeletal muscle cells involves a protein-tyrosine phosphatase-alpha-mediated C-Src signaling pathway.
The Journal of biological chemistry 2002;277(48):46687-95.
2002: Liang-Tung Yang; Konstantina Alexandropoulos; Jan Sap
c-SRC mediates neurite outgrowth through recruitment of Crk to the scaffolding protein Sin/Efs without altering the kinetics of ERK activation.
The Journal of biological chemistry 2002;277(20):17406-14.
2000: Elena Ardini; Roberto Agresti; Elda Tagliabue; M Greco; Piera Aiello; Liang-Tung Yang; Sylvie Ménard; Jan Sap
Expression of protein tyrosine phosphatase alpha (RPTPalpha) in human breast cancer correlates with low tumor grade, and inhibits tumor cell growth in vitro and in vivo.
Oncogene 2000;19(43):4979-87.
2000: A Petrone; Jan Sap
Emerging issues in receptor protein tyrosine phosphatase function: lifting fog or simply shifting?
Journal of cell science 2000;113 ( Pt 13)():2345-54.
1999: J Su; M Muranjan; Jan Sap
Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts.
Current biology : CB 1999;9(10):505-11.
1999: P Shen; PD Canoll; Jan Sap; J M Musacchio
Expression of a truncated receptor protein tyrosine phosphatase kappa in the brain of an adult transgenic mouse.
Brain research 1999;826(2):157-71.
1998: Kirsten K Jacob; Jan Sap; Frederick M Stanley
Receptor-like protein-tyrosine phosphatase alpha specifically inhibits insulin-increased prolactin gene expression.
The Journal of biological chemistry 1998;273(8):4800-9.
1996: J Su; L T Yang; Jan Sap
Association between receptor protein-tyrosine phosphatase RPTPalpha and the Grb2 adaptor. Dual Src homology (SH) 2/SH3 domain requirement and functional consequences.
The Journal of biological chemistry 1996;271(45):28086-96.
1995: GC Zondag; G M Koningstein; Y P Jiang; Jan Sap; Wouter H Moolenaar; M F Gebbink
Homophilic interactions mediated by receptor tyrosine phosphatases mu and kappa. A critical role for the novel extracellular MAM domain.
The Journal of biological chemistry 1995;270(24):14247-50.
1994: D M Desai; Jan Sap; O Silvennoinen; Joseph Schlessinger; Arthur Weiss
The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation.
The EMBO journal 1994;13(17):4002-10.
1994: J Su; A Batzer; Jan Sap
Receptor tyrosine phosphatase R-PTP-alpha is tyrosine-phosphorylated and associated with the adaptor protein Grb2.
The Journal of biological chemistry 1994;269(29):18731-4.
1994: Gilad Barnea; Martin Grumet; P Milev; O Silvennoinen; J B Levy; Jan Sap; Joseph Schlessinger
Receptor tyrosine phosphatase beta is expressed in the form of proteoglycan and binds to the extracellular matrix protein tenascin.
The Journal of biological chemistry 1994;269(20):14349-52.
1994: Gilad Barnea; Martin Grumet; Jan Sap; R U Margolis; Joseph Schlessinger
Close similarity between receptor-linked tyrosine phosphatase and rat brain proteoglycan.
Cell 1994;76(2):205.
1994: Jan Sap; Y P Jiang; David R Friedlander; Martin Grumet; Joseph Schlessinger
Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding.
Molecular and cellular biology 1994;14(1):1-9.
1993: P D Canoll; Gilad Barnea; J B Levy; Jan Sap; M Ehrlich; O Silvennoinen; Joseph Schlessinger; J M Musacchio
The expression of a novel receptor-type tyrosine phosphatase suggests a role in morphogenesis and plasticity of the nervous system.
Brain research. Developmental brain research 1993;75(2):293-8.
1993: D M Desai; Jan Sap; Joseph Schlessinger; Arthur Weiss
Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase.
Cell 1993;73(3):541-54.
1993: Y P Jiang; H Wang; Peter D'Eustachio; J M Musacchio; Joseph Schlessinger; Jan Sap
Cloning and characterization of R-PTP-kappa, a new member of the receptor protein tyrosine phosphatase family with a proteolytically cleaved cellular adhesion molecule-like extracellular region.
Molecular and cellular biology 1993;13(5):2942-51.
1990: Jan Sap; Peter D'Eustachio; D Givol; Joseph Schlessinger
Cloning and expression of a widely expressed receptor tyrosine phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(16):6112-6.