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Clifford Saper

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TOP 3
Satvinder Kaur; Michael Lazarus; Nigel P Pedersen; Nancy L Chamberlin; Patrick M Fuller; Elizabeth E Hur; Shigefumi Yokota; Clifford B Saper
Glutamatergic signaling from the parabrachial nucleus plays a critical role in hypercapnic arousal.
Clifford B Saper
The neurobiology of sleep.
Ramalingam Vetrivelan; Shigefumi Yokota; Patrick M Fuller; Jun Lu; Clifford B Saper
Metabolic effects of chronic sleep restriction in rats.

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2013: Satvinder Kaur; Michael Lazarus; Nigel P Pedersen; Nancy L Chamberlin; Patrick M Fuller; Elizabeth E Hur; Shigefumi Yokota; Clifford B Saper
Glutamatergic signaling from the parabrachial nucleus plays a critical role in hypercapnic arousal.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(18):7627-40.
2013: Clifford B Saper
The neurobiology of sleep.
Continuum (Minneapolis, Minn.) 2013;19(1 Sleep Disorders):19-31.
2012: Ramalingam Vetrivelan; Shigefumi Yokota; Patrick M Fuller; Jun Lu; Clifford B Saper
Metabolic effects of chronic sleep restriction in rats.
Sleep 2012;35(11):1511-20.
2012: Andrew S P Lim; Amanda Myers; Towfique Raj; Katherine Rothamel; Clifford B Saper; Joshua M Shulman; Jeanne F Duffy; David A Bennett; Christophe Benoist; Aron S Buchman; Sean W Cain; Anne-Marie Chang; Lori B Chibnik; Charles A Czeisler; Philip L De Jager
A common polymorphism near PER1 and the timing of human behavioral rhythms.
Annals of neurology 2012;72(3):324-34.
2012: Clifford B Saper; Andrej A Romanovsky; Thomas E Scammell
Neural circuitry engaged by prostaglandins during the sickness syndrome.
Nature neuroscience 2012;15(8):1088-95.
2012: Eveline Bruinstroop; Georgina Cano; Judney C Cavalcante; Miguel Sena-Esteves; Veronique G J M Vanderhorst; Jena Wirth; Clifford B Saper
Spinal projections of the A5, A6 (locus coeruleus), and A7 noradrenergic cell groups in rats.
The Journal of comparative neurology 2012;520(9):1985-2001.
2012: Andrew S P Lim; Lei Yu; David A Bennett; Aron S Buchman; Madalena D Costa; Sue E Leurgans; Clifford B Saper
Increased fragmentation of rest-activity patterns is associated with a characteristic pattern of cognitive impairment in older individuals.
Sleep 2012;35(5):633-40B.
2012: Patrick R Hof; Clifford B Saper
Passages 2012.
The Journal of comparative neurology 2012;520(1):1-5.
2011: Matthias Eikermann; Martina Grosse-Sundrup; Mark E Henry; Ulrike Hoffmann; Clifford B Saper; Ramalingam Vetrivelan; Shigefumi Yokota; Nancy L Chamberlin
The ventrolateral preoptic nucleus is not required for isoflurane general anesthesia.
Brain research 2011;1426():30-7.
2011: Andrew S P Lim; Lei Yu; David A Bennett; Aron S Buchman; Madalena D Costa; Sue E Leurgans; Clifford B Saper
Quantification of the fragmentation of rest-activity patterns in elderly individuals using a state transition analysis.
Sleep 2011;34(11):1569-81.
2011: Clifford B Saper
Goodbye to Edward G. (Ted) Jones, MD, DPhil, 1939-2011.
The Journal of comparative neurology 2011;519(16):3125-7.
2011: Patrick M Fuller; Patrick Fuller; David Sherman; Nigel P Pedersen; Clifford B Saper; Jun Lu
Reassessment of the structural basis of the ascending arousal system.
The Journal of comparative neurology 2011;519(5):933-56.
2011: Clifford B Saper
Animal behaviour: the nexus of sex and violence.
Nature 2011;470(7333):179-81.
2010: Clifford B Saper; Patrick M Fuller; Nigel P Pedersen; Jun Lu; Thomas E Scammell
Sleep state switching.
Neuron 2010;68(6):1023-42.
2010: Heinrich S Gompf; Christine Mathai; Patrick M Fuller; David A Wood; Nigel P Pedersen; Clifford B Saper; Jun Lu
Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(43):14543-51.
2010: Clifford B Saper; Robert Lenkinski
MR spectroscopy in translational neuroscience.
The Journal of comparative neurology 2010;518(20):4089-90.
2010: Clifford B Saper
A treasure trove of gene expression patterns.
Nature neuroscience 2010;13(6):658-9.
2010: Laurent Gautron; Michael Lazarus; Michael M Scott; Clifford B Saper; Joel K Elmquist
Identifying the efferent projections of leptin-responsive neurons in the dorsomedial hypothalamus using a novel conditional tracing approach.
The Journal of comparative neurology 2010;518(11):2090-108.
2010: Rodrigo Noseda; Vanessa Kainz; Moshe Jakubowski; Joshua J Gooley; Clifford B Saper; Kathleen Digre; Rami Burstein
A neural mechanism for exacerbation of headache by light.
Nature neuroscience 2010;13(2):239-45.
2010: Yuko Kataoka; Paul S A Kalanithi; Heidi Grantz; Michael L Schwartz; Clifford B Saper; James F Leckman; Flora M Vaccarino
Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome.
The Journal of comparative neurology 2010;518(3):277-91.
2010: Clifford B Saper
The dance of the perivascular and endothelial cells: mechanisms of brain response to immune signaling.
Neuron 2010;65(1):4-6.
2009: Nancy L Chamberlin; Clifford B Saper
The agony of the ecstasy: serotonin and obstructive sleep apnea.
Neurology 2009;73(23):1947-8.
2009: Elda Arrigoni; Jun Lu; Ramalingam Vetrivelan; Clifford B Saper
Long-term synaptic plasticity is impaired in rats with lesions of the ventrolateral preoptic nucleus.
The European journal of neuroscience 2009;30(11):2112-20.
2009: Clifford B Saper
Opening up the JCN toolbox.
The Journal of comparative neurology 2009;516(6):455.
2009: Kyoko Yoshida; Xiaodong Li; Georgina Cano; Michael Lazarus; Clifford B Saper
Parallel preoptic pathways for thermoregulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(38):11954-64.
2009: Clifford B Saper; John H R Maunsell
The neuroscience peer review consortium.
Brain structure & function 2009;213(4-5):359-61.
2009: Clifford B Saper; John H R Maunsell
The Neuroscience Peer Review Consortium.
Neuroscience letters 2009;457(1):1-2.
2009: Clifford B Saper; John H R Maunsell
The Neuroscience Peer Review Consortium.
Neuroinformatics 2009;7(2):89-91.
2009: Luiz G S Branco; Thiago S Moreira; Patrice G Guyenet; Peter M Lalley; A Kawai; Robert W Putnam; Nancy L Chamberlin; Clifford B Saper; Alexander V Gourine; Mitsuko Kanamaru; Ikuo Homma
Commentaries on Viewpoint: Central chemoreception is a complex system function that involves multiple brain stem sites.
Journal of applied physiology (Bethesda, Md. : 1985) 2009;106(4):1467-70.
2009: Thomas C Jhou; Howard Fields; Mark G Baxter; Clifford B Saper; Peter C Holland
The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses.
Neuron 2009;61(5):786-800.
2009: Clifford B Saper
The Neuroscience Peer Review Consortium.
Neurobiology of disease 2009;33(3):313-4.
2009: Clifford B Saper
The Neuroscience Peer Review Consortium.
Experimental neurology 2009;216(1):1-2.
2009: Clifford B Saper; John H R Maunsell
The Neuroscience Peer Review Consortium.
The European journal of neuroscience 2009;29(3):435-6.
2009: Daniel Vardeh; Dairong Wang; Michael Costigan; Michael Lazarus; Clifford B Saper; Clifford J Woolf; garret fitzgerald; Tarek A Samad
COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice.
The Journal of clinical investigation 2009;119(2):287-94.
2009: Patrick M Fuller; Jun Lu; Clifford B Saper
Standards of evidence in chronobiology: A response.
Journal of circadian rhythms 2009;7():9.
2009: Clifford B Saper; John H R Maunsell
The Neuroscience Peer Review Consortium.
Neural development 2009;4():10.
2009: Clifford B Saper; John Maunsell
Neuroendocrinologies membership of the Neuroscience Peer Review Consortium.
Neuroendocrinology 2009;89(1):1-2.
2009: Clifford B Saper; John Maunsell; Terje Sagvolden
The neuroscience peer review consortium.
Behavioral and brain functions : BBF 2009;5():4.
2008: Beverley A Orser; Clifford B Saper
Multimodal anesthesia and systems neuroscience: the new frontier.
Anesthesiology 2008;109(6):948-50.
2008: Georgina Cano; Takatoshi Mochizuki; Clifford B Saper
Neural circuitry of stress-induced insomnia in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(40):10167-84.
2008: Jun Lu; Laura E Nelson; Nick Franks; Mervyn Maze; Nancy L Chamberlin; Clifford B Saper
Role of endogenous sleep-wake and analgesic systems in anesthesia.
The Journal of comparative neurology 2008;508(4):648-62.
2008: Patrick M Fuller; Jun Lu; Clifford B Saper
Differential rescue of light- and food-entrainable circadian rhythms.
Science (New York, N.Y.) 2008;320(5879):1074-7.
2008: Hiroyoshi Tsuchiya; Takakazu Oka; Kazuhiro Nakamura; Atsushi Ichikawa; Clifford B Saper; Yukihiko Sugimoto
Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors.
The Journal of biological chemistry 2008;283(16):11064-71.
2007: Joshua J Gooley; Clifford B Saper
Is food-directed behavior an appropriate measure of circadian entrainment to restricted daytime feeding?
Journal of biological rhythms 2007;22(6):479-83.
2007: Patrick M Fuller; Clifford B Saper; Jun Lu
The pontine REM switch: past and present.
The Journal of physiology 2007;584(Pt 3):735-41.
2007: Michael Lazarus; Kyoko Yoshida; Roberto Coppari; Caroline E Bass; Takatoshi Mochizuki; Bradford B Lowell; Clifford B Saper
EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses.
Nature neuroscience 2007;10(9):1131-3.
2007: Clifford B Saper
In living color.
The Journal of comparative neurology 2007;502(2):173-4.
2007: Inna Sukhotinsky; V Zalkind; Jun Lu; David A Hopkins; Clifford B Saper; Marshall Devor
Neural pathways associated with loss of consciousness caused by intracerebral microinjection of GABA A-active anesthetics.
The European journal of neuroscience 2007;25(5):1417-36.
2007: Thomas E Scammell; Clifford B Saper
Orexins: looking forward to sleep, back at addiction.
Nature medicine 2007;13(2):126-8.
2007: Clifford B Saper; P M Fuller
Inducible clocks: living in an unpredictable world.
Cold Spring Harbor symposia on quantitative biology 2007;72():543-50.
2006: Patrick M Fuller; Joshua J Gooley; Clifford B Saper
Neurobiology of the sleep-wake cycle: sleep architecture, circadian regulation, and regulatory feedback.
Journal of biological rhythms 2006;21(6):482-93.
2006: Inna Sukhotinsky; Keren Reiner; Ruth Govrin-Lippmann; Michael A Belenky; Jun Lu; David A Hopkins; Clifford B Saper; Marshall Devor
Projections from the mesopontine tegmental anesthesia area to regions involved in pain modulation.
Journal of chemical neuroanatomy 2006;32(2-4):159-78.
2006: Clifford B Saper
Biomedicine. Life, the universe, and body temperature.
Science (New York, N.Y.) 2006;314(5800):773-4.
2006: Clifford B Saper
No place for secrets in scientific research.
Nature 2006;442(7101):353.
2006: Elda Arrigoni; Nancy L Chamberlin; Clifford B Saper; Robert W McCarley
Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro.
Neuroscience 2006;140(2):403-13.
2006: Jun Lu; David Sherman; Marshall Devor; Clifford B Saper
A putative flip-flop switch for control of REM sleep.
Nature 2006;441(7093):589-94.
2006: William P Cheshire; Clifford B Saper
The insular cortex and cardiac response to stroke.
Neurology 2006;66(9):1296-7.
2006: Bradley Boeve; Clifford B Saper
REM sleep behavior disorder: a possible early marker for synucleinopathies.
Neurology 2006;66(6):796-7.
2006: Joshua J Gooley; Ashley Schomer; Clifford B Saper
The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms.
Nature neuroscience 2006;9(3):398-407.
2006: Jeffrey M Zigman; Juli E Jones; Charlotte E Lee; Clifford B Saper; Joel K Elmquist
Expression of ghrelin receptor mRNA in the rat and the mouse brain.
The Journal of comparative neurology 2006;494(3):528-48.
2006: Jun Lu; Thomas C Jhou; Clifford B Saper
Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(1):193-202.
2006: Clifford B Saper
Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms.
Progress in brain research 2006;153():243-52.
2005: Clifford B Saper
An open letter to our readers on the use of antibodies.
The Journal of comparative neurology 2005;493(4):477-8.
2005: Clifford B Saper; Georgina Cano; Thomas E Scammell
Homeostatic, circadian, and emotional regulation of sleep.
The Journal of comparative neurology 2005;493(1):92-8.
2005: Clifford B Saper; Thomas E Scammell; Jun Lu
Hypothalamic regulation of sleep and circadian rhythms.
Nature 2005;437(7063):1257-63.
2005: Amanda Crocker; Rodrigo A España; M Papadopoulou; Clifford B Saper; J Faraco; Takeshi Sakurai; M Honda; E Mignot; Thomas E Scammell
Concomitant loss of dynorphin, NARP, and orexin in narcolepsy.
Neurology 2005;65(8):1184-8.
2005: Andrew W Tarulli; Chun Lim; Jonathan D Bui; Clifford B Saper; Michael P Alexander
Central neurogenic hyperventilation: a case report and discussion of pathophysiology.
Archives of neurology 2005;62(10):1632-4.
2005: Thomas E Scammell; Clifford B Saper
Orexin, drugs and motivated behaviors.
Nature neuroscience 2005;8(10):1286-8.
2005: Paul S A Kalanithi; Wei Zheng; Yuko Kataoka; Marian DiFiglia; Heidi Grantz; Clifford B Saper; Michael L Schwartz; James F Leckman; Flora M Vaccarino
Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(37):13307-12.
2005: Inna Sukhotinsky; David A Hopkins; Jun Lu; Clifford B Saper; Marshall Devor
Movement suppression during anesthesia: neural projections from the mesopontine tegmentum to areas involved in motor control.
The Journal of comparative neurology 2005;489(4):425-48.
2005: Daphne J Holt; Susan E Bachus; Thomas M Hyde; Michael Wittie; Mary M Herman; Mark Vangel; Clifford B Saper; Joel E Kleinman
Reduced density of cholinergic interneurons in the ventral striatum in schizophrenia: an in situ hybridization study.
Biological psychiatry 2005;58(5):408-16.
2005: Clifford B Saper; Jun Lu; Thomas C Chou; Joshua Gooley
The hypothalamic integrator for circadian rhythms.
Trends in neurosciences 2005;28(3):152-7.
2005: Elda Arrigoni; Amanda Crocker; Clifford B Saper; Robert W Greene; Thomas E Scammell
Deletion of presynaptic adenosine A1 receptors impairs the recovery of synaptic transmission after hypoxia.
Neuroscience 2005;132(3):575-80.
2004: Thomas C Chou; Stephen R Rotman; Clifford B Saper
Lateral hypothalamic acetylcholinesterase-immunoreactive neurons co-express either orexin or melanin concentrating hormone.
Neuroscience letters 2004;370(2-3):123-6.
2004: Dmitry Gerashchenko; Thomas C Chou; Carlos Blanco-Centurion; Clifford B Saper; Priyattam J Shiromani
Effects of lesions of the histaminergic tuberomammillary nucleus on spontaneous sleep in rats.
Sleep 2004;27(7):1275-81.
2004: Joseph F Kelly; Carol F Elias; Charlotte E Lee; Rexford S Ahima; Randy J Seeley; Christian Bjørbaek; Takakazu Oka; Clifford B Saper; Jeffrey S Flier; Joel K Elmquist
Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain.
Diabetes 2004;53(4):911-20.
2004: Clifford B Saper; Thomas E Scammell
Modafinil: a drug in search of a mechanism.
Sleep 2004;27(1):11-2.
2003: Jean K Matheson; Clifford B Saper
REM sleep behavior disorder: a dopaminergic deficiency disorder?
Neurology 2003;61(10):1328-9.
2003: Thomas C Chou; Thomas E Scammell; Joshua J Gooley; Stephanie E Gaus; Clifford B Saper; Jun Lu
Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(33):10691-702.
2003: Clifford B Saper; Paul E Sawchenko
Magic peptides, magic antibodies: guidelines for appropriate controls for immunohistochemistry.
The Journal of comparative neurology 2003;465(2):161-3.
2003: Takakazu Oka; Kae Oka; Takuya Kobayashi; Yukihiko Sugimoto; Atsushi Ichikawa; Fumitaka Ushikubi; Shuh Narumiya; Clifford B Saper
Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors.
The Journal of physiology 2003;551(Pt 3):945-54.
2003: Yi-Hong Zhang; Jun Lu; Joel K Elmquist; Clifford B Saper
Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain.
The Journal of comparative neurology 2003;463(1):3-12.
2003: Joshua J Gooley; Jun Lu; Dietmar Fischer; Clifford B Saper
A broad role for melanopsin in nonvisual photoreception.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(18):7093-106.
2003: Thomas E Scammell; Elda Arrigoni; Margaret A Thompson; Patrick J Ronan; Clifford B Saper; Robert W Greene
Focal deletion of the adenosine A1 receptor in adult mice using an adeno-associated viral vector.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(13):5762-70.
2003: Takakazu Oka; Kae Oka; Clifford B Saper
Contrasting effects of E type prostaglandin (EP) receptor agonists on core body temperature in rats.
Brain research 2003;968(2):256-62.
2003: Toshiro Kishi; Carl J Aschkenasi; Charlotte E Lee; Kathleen G Mountjoy; Clifford B Saper; Joel K Elmquist
Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat.
The Journal of comparative neurology 2003;457(3):213-35.
2003: Laura E Nelson; Jun Lu; Tianzhi Guo; Clifford B Saper; Nicholas P Franks; Mervyn Maze
The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects.
Anesthesiology 2003;98(2):428-36.
2003: F Torrealba; M Yanagisawa; Clifford B Saper
Colocalization of orexin a and glutamate immunoreactivity in axon terminals in the tuberomammillary nucleus in rats.
Neuroscience 2003;119(4):1033-44.
2003: Nancy L Chamberlin; Elda Arrigoni; Thomas C Chou; Thomas E Scammell; Robert W Greene; Clifford B Saper
Effects of adenosine on gabaergic synaptic inputs to identified ventrolateral preoptic neurons.
Neuroscience 2003;119(4):913-8.
2002: Clifford B Saper; Thomas C Chou; Joel K Elmquist
The need to feed: homeostatic and hedonic control of eating.
Neuron 2002;36(2):199-211.
2002: Laura E Nelson; Tian-Zhi Guo; J Lu; Clifford B Saper; Nicholas P Franks; Mervyn Maze
The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway.
Nature neuroscience 2002;5(10):979-84.
2002: Hiroshi Yamamoto; Charlotte E Lee; Jacob N Marcus; Todd D Williams; J Michael Overton; Marisol E Lopez; Anthony N Hollenberg; Laurie Baggio; Clifford B Saper; Daniel J Drucker; Joel K Elmquist
Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons.
The Journal of clinical investigation 2002;110(1):43-52.
2002: Jun Lu; Alvhild A Bjorkum; Man Xu; Stephanie E Gaus; Priyattam J Shiromani; Clifford B Saper
Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleep.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(11):4568-76.
2002: Thomas C Chou; Alvhild A Bjorkum; Stephanie E Gaus; Jun Lu; Thomas E Scammell; Clifford B Saper
Afferents to the ventrolateral preoptic nucleus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(3):977-90.
2002: Clifford B Saper
The central autonomic nervous system: conscious visceral perception and autonomic pattern generation.
Annual review of neuroscience 2002;25():433-69.
2001: J J Gooley; Jun Lu; Thomas C Chou; Thomas E Scammell; Clifford B Saper
Melanopsin in cells of origin of the retinohypothalamic tract.
Nature neuroscience 2001;4(12):1165.
2001: Thomas C Chou; Charlotte E Lee; Jun Lu; Joel K Elmquist; J Hara; Jon T Willie; Carsten T Beuckmann; Richard M Chemelli; Takeshi Sakurai; Masashi Yanagisawa; Clifford B Saper; Thomas E Scammell
Orexin (hypocretin) neurons contain dynorphin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(19):RC168.
2001: A Malick; Moshe Jakubowski; Joel K Elmquist; Clifford B Saper; Rami Burstein
A neurohistochemical blueprint for pain-induced loss of appetite.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9930-5.
2001: Jun Lu; Y H Zhang; Thomas C Chou; Stephanie E Gaus; Joel K Elmquist; Priyattam J Shiromani; Clifford B Saper
Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(13):4864-74.
2001: Thomas E Scammell; S Nishino; E Mignot; Clifford B Saper
Narcolepsy and low CSF orexin (hypocretin) concentration after a diencephalic stroke.
Neurology 2001;56(12):1751-3.
2001: Jacob N Marcus; Carl J Aschkenasi; Charlotte E Lee; Richard M Chemelli; Clifford B Saper; Masashi Yanagisawa; Joel K Elmquist
Differential expression of orexin receptors 1 and 2 in the rat brain.
The Journal of comparative neurology 2001;435(1):6-25.
2001: CF Elias; Charlotte E Lee; JF Kelly; Rexford S Ahima; Michael J Kuhar; Clifford B Saper; Joel K Elmquist
Characterization of CART neurons in the rat and human hypothalamus.
The Journal of comparative neurology 2001;432(1):1-19.
2001: Ivy V Estabrooke; MT McCarthy; E Ko; Thomas C Chou; Richard M Chemelli; Masashi Yanagisawa; Clifford B Saper; Thomas E Scammell
Fos expression in orexin neurons varies with behavioral state.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(5):1656-62.
2001: Thomas E Scammell; DY Gerashchenko; T Mochizuki; MT McCarthy; Ivy V Estabrooke; C A Sears; Clifford B Saper; Yoshihiro Urade; Osamu Hayaishi
An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons.
Neuroscience 2001;107(4):653-63.
2000: T Oka; K Oka; Thomas E Scammell; C Lee; JF Kelly; F Nantel; Joel K Elmquist; Clifford B Saper
Relationship of EP(1-4) prostaglandin receptors with rat hypothalamic cell groups involved in lipopolysaccharide fever responses.
The Journal of comparative neurology 2000;428(1):20-32.
2000: Thomas E Scammell; Ivy V Estabrooke; MT McCarthy; Richard M Chemelli; Masashi Yanagisawa; M S Miller; Clifford B Saper
Hypothalamic arousal regions are activated during modafinil-induced wakefulness.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(22):8620-8.
2000: Y H Zhang; Jun Lu; Joel K Elmquist; Clifford B Saper
Lipopolysaccharide activates specific populations of hypothalamic and brainstem neurons that project to the spinal cord.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(17):6578-86.
2000: CF Elias; JF Kelly; Charlotte E Lee; Rexford S Ahima; D J Drucker; Clifford B Saper; Joel K Elmquist
Chemical characterization of leptin-activated neurons in the rat brain.
The Journal of comparative neurology 2000;423(2):261-81.
2000: Jun Lu; Mary A Greco; Priyattam J Shiromani; Clifford B Saper
Effect of lesions of the ventrolateral preoptic nucleus on NREM and REM sleep.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(10):3830-42.
2000: Clifford B Saper
Hypothalamic connections with the cerebral cortex.
Progress in brain research 2000;126():39-48.
2000: S de Lacalle; Clifford B Saper
Calcitonin gene-related peptide-like immunoreactivity marks putative visceral sensory pathways in human brain.
Neuroscience 2000;100(1):115-30.
2000: Clifford B Saper
Pain as a visceral sensation.
Progress in brain research 2000;122():237-43.
1999: Richard M Chemelli; Jon T Willie; Christopher M Sinton; Joel K Elmquist; Thomas E Scammell; Charles Lee; James A Richardson; S Clay Williams; Y Xiong; Yaz Y Kisanuki; TE Fitch; M Nakazato; Robert E Hammer; Clifford B Saper; Masashi Yanagisawa
Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.
Cell 1999;98(4):437-51.
1999: CF Elias; Carl J Aschkenasi; C Lee; J Kelly; Rexford S Ahima; C Bjorbaek; Jeffrey S Flier; Clifford B Saper; Joel K Elmquist
Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area.
Neuron 1999;23(4):775-86.
1999: NL Chamberlin; A Mansour; Stanley J Watson Jr; Clifford B Saper
Localization of mu-opioid receptors on amygdaloid projection neurons in the parabrachial nucleus of the rat.
Brain research 1999;827(1-2):198-204.
1999: Dara S Manoach; Daniel Z Press; V Thangaraj; M M Searl; Donald C Goff; Elkan Halpern; Clifford B Saper; S Warach
Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI.
Biological psychiatry 1999;45(9):1128-37.
1999: KF Manaye; R Zweig; D Wu; Louis B Hersh; S De Lacalle; Clifford B Saper; Dwight C German
Quantification of cholinergic and select non-cholinergic mesopontine neuronal populations in the human brain.
Neuroscience 1999;89(3):759-70.
1999: Joel K Elmquist; CF Elias; Clifford B Saper
From lesions to leptin: hypothalamic control of food intake and body weight.
Neuron 1999;22(2):221-32.
1999: Daphne J Holt; Mary M Herman; Thomas M Hyde; Joel E Kleinman; Christopher M Sinton; Dwight C German; Louis B Hersh; Ann M Graybiel; Clifford B Saper
Evidence for a deficit in cholinergic interneurons in the striatum in schizophrenia.
Neuroscience 1999;94(1):21-31.
1999: Jun Lu; Priyattam J Shiromani; Clifford B Saper
Retinal input to the sleep-active ventrolateral preoptic nucleus in the rat.
Neuroscience 1999;93(1):209-14.
1998: CF Elias; Clifford B Saper; Eleftheria Maratos-Flier; Nicholas A Tritos; C Lee; J Kelly; Jeffrey B Tatro; Gloria E Hoffman; MM Ollmann; Gregory S Barsh; T Sakurai; Masashi Yanagisawa; Joel K Elmquist
Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area.
The Journal of comparative neurology 1998;402(4):442-59.
1998: CF Elias; C Lee; J Kelly; Carl J Aschkenasi; Rexford S Ahima; P R Couceyro; Michael J Kuhar; Clifford B Saper; Joel K Elmquist
Leptin activates hypothalamic CART neurons projecting to the spinal cord.
Neuron 1998;21(6):1375-85.
1998: NL Chamberlin; Clifford B Saper
A brainstem network mediating apneic reflexes in the rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(15):6048-56.
1998: Thomas E Scammell; DY Gerashchenko; Yoshihiro Urade; H Onoe; Clifford B Saper; Osamu Hayaishi
Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7754-9.
1998: Joel K Elmquist; Christian Bjørbaek; Rexford S Ahima; Jeffrey S Flier; Clifford B Saper
Distributions of leptin receptor mRNA isoforms in the rat brain.
The Journal of comparative neurology 1998;395(4):535-47.
1998: JE Sherin; Joel K Elmquist; F Torrealba; Clifford B Saper
Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(12):4705-21.
1998: Thomas E Scammell; J D Griffin; Joel K Elmquist; Clifford B Saper
Microinjection of a cyclooxygenase inhibitor into the anteroventral preoptic region attenuates LPS fever.
The American journal of physiology 1998;274(3 Pt 2):R783-9.
1998: Joel K Elmquist; Rexford S Ahima; C F Elias; Jeffrey S Flier; Clifford B Saper
Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):741-6.
1997: R Basheer; JE Sherin; Clifford B Saper; J I Morgan; R W McCarley; Priyattam J Shiromani
Effects of sleep on wake-induced c-fos expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(24):9746-50.
1997: C Lim; Elliott J Mufson; Jeffrey Kordower; H W Blume; J R Madsen; Clifford B Saper
Connections of the hippocampal formation in humans: II. The endfolial fiber pathway.
The Journal of comparative neurology 1997;385(3):352-71.
1997: C Lim; H W Blume; J R Madsen; Clifford B Saper
Connections of the hippocampal formation in humans: I. The mossy fiber pathway.
The Journal of comparative neurology 1997;385(3):325-51.
1997: Daphne J Holt; Ann M Graybiel; Clifford B Saper
Neurochemical architecture of the human striatum.
The Journal of comparative neurology 1997;384(1):1-25.
1997: Joel K Elmquist; Christopher Breder; JE Sherin; Thomas E Scammell; W F Hickey; D Dewitt; Clifford B Saper
Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages.
The Journal of comparative neurology 1997;381(2):119-29.
1996: Joel K Elmquist; Clifford B Saper
Activation of neurons projecting to the paraventricular hypothalamic nucleus by intravenous lipopolysaccharide.
The Journal of comparative neurology 1996;374(3):315-31.
1996: Thomas E Scammell; Joel K Elmquist; James D Griffin; Clifford B Saper
Ventromedial preoptic prostaglandin E2 activates fever-producing autonomic pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(19):6246-54.
1996: D J Holt; Louis B Hersh; Clifford B Saper
Cholinergic innervation in the human striatum: a three-compartment model.
Neuroscience 1996;74(1):67-87.
1996: Thomas E Scammell; Joel K Elmquist; Clifford B Saper
Inhibition of nitric oxide synthase produces hypothermia and depresses lipopolysaccharide fever.
The American journal of physiology 1996;271(2 Pt 2):R333-8.
1996: Joel K Elmquist; Thomas E Scammell; CD Jacobson; Clifford B Saper
Distribution of Fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration.
The Journal of comparative neurology 1996;371(1):85-103.
1996: PETER NELSON; Clifford B Saper
Injections of okadaic acid, but not beta-amyloid peptide, induce Alz-50 immunoreactive dystrophic neurites in the cerebral cortex of sheep.
Neuroscience letters 1996;208(2):77-80.
1996: Christopher Breder; Clifford B Saper
Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide.
Brain research 1996;713(1-2):64-9.
1996: J E Sherin; Priyattam J Shiromani; Robert W McCarley; Clifford B Saper
Activation of ventrolateral preoptic neurons during sleep.
Science (New York, N.Y.) 1996;271(5246):216-9.
1996: Clifford B Saper
Role of the cerebral cortex and striatum in emotional motor response.
Progress in brain research 1996;107():537-50.
1995: N L Chamberlin; Clifford B Saper
Differential distribution of AMPA-selective glutamate receptor subunits in the parabrachial nucleus of the rat.
Neuroscience 1995;68(2):435-43.
1995: Clifford B Saper
Of hearts and minds: natriuretic peptides in the brain.
The Journal of comparative neurology 1995;356(2):166-7.
1995: PETER NELSON; Clifford B Saper
Ultrastructure of neurofibrillary tangles in the cerebral cortex of sheep.
Neurobiology of aging 1995;16(3):315-23.
1995: Clifford B Saper
The spinoparabrachial pathway: shedding new light on an old path.
The Journal of comparative neurology 1995;353(4):477-9.
1994: Christopher Breder; C Hazuka; T Ghayur; C Klug; M Huginin; K Yasuda; M Teng; Clifford B Saper
Regional induction of tumor necrosis factor alpha expression in the mouse brain after systemic lipopolysaccharide administration.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11393-7.
1994: N L Chamberlin; Clifford B Saper
Topographic organization of respiratory responses to glutamate microstimulation of the parabrachial nucleus in the rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(11 Pt 1):6500-10.
1994: S De Lacalle; C Lim; T Sobreviela; Elliott J Mufson; Louis B Hersh; Clifford B Saper
Cholinergic innervation in the human hippocampal formation including the entorhinal cortex.
The Journal of comparative neurology 1994;345(3):321-44.
1994: PETER NELSON; S G Greenberg; Clifford B Saper
Neurofibrillary tangles in the cerebral cortex of sheep.
Neuroscience letters 1994;170(1):187-90.
1993: Christopher Breder; M Tsujimoto; Y Terano; D W Scott; Clifford B Saper
Distribution and characterization of tumor necrosis factor-alpha-like immunoreactivity in the murine central nervous system.
The Journal of comparative neurology 1993;337(4):543-67.
1993: Clifford B Saper
Limitations of morphological studies in human brain: opportunities for studies in nonhuman primates.
Neurobiology of aging 1993;14(6):705-6.
1993: S de Lacalle; Louis B Hersh; Clifford B Saper
Cholinergic innervation of the human cerebellum.
The Journal of comparative neurology 1993;328(3):364-76.
1993: PETER NELSON; L Marton; Clifford B Saper
Alz-50 immunohistochemistry in the normal sheep striatum: a light and electron microscope study.
Brain research 1993;600(2):285-97.
1993: Clifford B Saper
On not-so-simple tests of simple hypotheses: a commentary on the review and model system by De Lacoste and White.
Neurobiology of aging 1993;14(1):49-50; discussion 55-6.
1992: K Yasuda; S Rens-Domiano; Christopher Breder; S F Law; Clifford B Saper; Terry Reisine; Graeme I Bell
Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase.
The Journal of biological chemistry 1992;267(28):20422-8.
1992: Christopher Breder; Yoshihiko Yamada; K Yasuda; S Seino; Clifford B Saper; Graeme I Bell
Differential expression of somatostatin receptor subtypes in brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(10):3920-34.
1992: Christopher Breder; William L Smith; A Raz; J Masferrer; K Seibert; P Needleman; Clifford B Saper
Distribution and characterization of cyclooxygenase immunoreactivity in the ovine brain.
The Journal of comparative neurology 1992;322(3):409-38.
1992: Clifford B Saper; Christopher Breder
Endogenous pyrogens in the CNS: role in the febrile response.
Progress in brain research 1992;93():419-28; discussion 428-9.
1991: S E Spencer; Melina R Kibbe; K M Hurley; P Needleman; Clifford B Saper
Origin of porcine brain natriuretic peptide-like immunoreactive innervation of the middle cerebral artery in the rat.
Neuroscience letters 1991;128(2):217-20.
1991: Yukihiko Yasui; Clifford B Saper; D F Cechetto
Calcitonin gene-related peptide (CGRP) immunoreactive projections from the thalamus to the striatum and amygdala in the rat.
The Journal of comparative neurology 1991;308(2):293-310.
1991: K M Hurley; H Herbert; M M Moga; Clifford B Saper
Efferent projections of the infralimbic cortex of the rat.
The Journal of comparative neurology 1991;308(2):249-76.
1991: Clifford B Saper; D M Sorrentino; Dwight C German; S de Lacalle
Medullary catecholaminergic neurons in the normal human brain and in Parkinson's disease.
Annals of neurology 1991;29(6):577-84.
1991: Yukihiko Yasui; Christopher Breder; Clifford B Saper; D F Cechetto
Autonomic responses and efferent pathways from the insular cortex in the rat.
The Journal of comparative neurology 1991;303(3):355-74.
1990: Clifford B Saper; Melina R Kibbe; K M Hurley; S Spencer; H R Holmes; K M Leahy; P Needleman
Brain natriuretic peptide-like immunoreactive innervation of the cardiovascular and cerebrovascular systems in the rat.
Circulation research 1990;67(6):1345-54.
1990: Clifford B Saper; Melina R Kibbe; K M Hurley; S Spencer
Brain natriuretic peptide-like immunoreactive innervation of the cerebrovascular system in the rat.
Stroke; a journal of cerebral circulation 1990;21(11 Suppl):III166-7.
1990: Yukihiko Yasui; D F Cechetto; Clifford B Saper
Evidence for a cholinergic projection from the pedunculopontine tegmental nucleus to the rostral ventrolateral medulla in the rat.
Brain research 1990;517(1-2):19-24.
1990: M M Moga; Clifford B Saper; Thackery S Gray
Neuropeptide organization of the hypothalamic projection to the parabrachial nucleus in the rat.
The Journal of comparative neurology 1990;295(4):662-82.
1990: M M Moga; H Herbert; K M Hurley; Yukihiko Yasui; Thackery S Gray; Clifford B Saper
Organization of cortical, basal forebrain, and hypothalamic afferents to the parabrachial nucleus in the rat.
The Journal of comparative neurology 1990;295(4):624-61.
1990: H Herbert; Clifford B Saper
Cholecystokinin-, galanin-, and corticotropin-releasing factor-like immunoreactive projections from the nucleus of the solitary tract to the parabrachial nucleus in the rat.
The Journal of comparative neurology 1990;293(4):581-98.
1990: H Herbert; M M Moga; Clifford B Saper
Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat.
The Journal of comparative neurology 1990;293(4):540-80.
1989: Yukihiko Yasui; Clifford B Saper; D F Cechetto
Calcitonin gene-related peptide immunoreactivity in the visceral sensory cortex, thalamus, and related pathways in the rat.
The Journal of comparative neurology 1989;290(4):487-501.
1989: Dwight C German; KF Manaye; W K Smith; D J Woodward; Clifford B Saper
Midbrain dopaminergic cell loss in Parkinson's disease: computer visualization.
Annals of neurology 1989;26(4):507-14.
1989: M M Moga; Clifford B Saper; Thackery S Gray
Bed nucleus of the stria terminalis: cytoarchitecture, immunohistochemistry, and projection to the parabrachial nucleus in the rat.
The Journal of comparative neurology 1989;283(3):315-32.
1989: Clifford B Saper; K M Hurley; M M Moga; H R Holmes; S A Adams; K M Leahy; P Needleman
Brain natriuretic peptides: differential localization of a new family of neuropeptides.
Neuroscience letters 1989;96(1):29-34.
1988: D F Cechetto; Clifford B Saper
Neurochemical organization of the hypothalamic projection to the spinal cord in the rat.
The Journal of comparative neurology 1988;272(4):579-604.
1988: Christopher Breder; C A Dinarello; Clifford B Saper
Interleukin-1 immunoreactive innervation of the human hypothalamus.
Science (New York, N.Y.) 1988;240(4850):321-4.
1988: D B Rye; H J Lee; Clifford B Saper; B H Wainer
Medullary and spinal efferents of the pedunculopontine tegmental nucleus and adjacent mesopontine tegmentum in the rat.
The Journal of comparative neurology 1988;269(3):315-41.
1987: Clifford B Saper
The value of alternative morphological approaches to Alzheimer's disease.
Neurobiology of aging 1987;8(6):576-7.
1987: Clifford B Saper; B H Wainer; Dwight C German
Axonal and transneuronal transport in the transmission of neurological disease: potential role in system degenerations, including Alzheimer's disease.
Neuroscience 1987;23(2):389-98.