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Gopal Sapkota

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TOP 3
David L Bruce; Thomas Macartney; Weinian Shou; Weidong Yong; Gopal P Sapkota
Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-β pathway.
David L Bruce; Gopal P Sapkota
Phosphatases in SMAD regulation.
Janis Vogt; Ryan Traynor; Gopal P Sapkota
The specificities of small molecule inhibitors of the TGFß and BMP pathways.

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All Publications

2012: David L Bruce; Thomas Macartney; Weinian Shou; Weidong Yong; Gopal P Sapkota
Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-β pathway.
Cellular signalling 2012;24(11):1999-2006.
2012: David L Bruce; Gopal P Sapkota
Phosphatases in SMAD regulation.
FEBS letters 2012;586(14):1897-905.
2011: Janis Vogt; Ryan Traynor; Gopal P Sapkota
The specificities of small molecule inhibitors of the TGFß and BMP pathways.
Cellular signalling 2011;23(11):1831-42.
2007: Gopal P Sapkota; Lorna Cummings; Felicity S Newell; Christopher Armstrong; Jenny Bain; Morten Frodin; Matthias Grauert; Matthias Hoffmann; Gisela Schnapp; Martin Steegmaier; Philip Cohen; Dario R Alessi
BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.
The Biochemical journal 2007;401(1):29-38.
2004: Clive P Morgan; Alison Skippen; Bruno Segui; Andrew Ball; Victoria Allen-Baume; Banafshé Larijani; Judith Murray-Rust; Neil McDonald; Gopal P Sapkota; Nick Morrice; Shamshad Cockcroft
Phosphorylation of a distinct structural form of phosphatidylinositol transfer protein alpha at Ser166 by protein kinase C disrupts receptor-mediated phospholipase C signaling by inhibiting delivery of phosphatidylinositol to membranes.
The Journal of biological chemistry 2004;279(45):47159-71.
2003: Jérôme Boudeau; Gopal P Sapkota; Dario R Alessi
LKB1, a protein kinase regulating cell proliferation and polarity.
FEBS letters 2003;546(1):159-65.
2003: Annette F Baas; Jérôme Boudeau; Gopal P Sapkota; Linda Smit; R Medema; Nick A Morrice; Dario R Alessi; Hans Clevers
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
The EMBO journal 2003;22(12):3062-72.
2002: Gopal P Sapkota; Maria Deak; Agnieszka Kieloch; Nick Morrice; ALI GOODARZI; Carl Smythe; Yosef Shiloh; Susan Lees-Miller; Dario R Alessi
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
The Biochemical journal 2002;368(Pt 2):507-16.
2002: Pauline Douglas; Gopal P Sapkota; Nick Morrice; Yaping Yu; ALI GOODARZI; Dennis Merkle; Katheryn Meek; Dario R Alessi; Susan Lees-Miller
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.
The Biochemical journal 2002;368(Pt 1):243-51.
2002: Gopal P Sapkota; Jérôme Boudeau; Maria Deak; Agnieszka Kieloch; Nick Morrice; Dario R Alessi
Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome.
The Biochemical journal 2002;362(Pt 2):481-90.
2001: Gopal P Sapkota; Agnieszka Kieloch; Jose Lizcano; Sonia Lain; J Simon C Arthur; Michayla R Williams; Nick Morrice; Maria Deak; Dario R Alessi
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.
The Journal of biological chemistry 2001;276(22):19469-82.