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Alain Sarasin

Research Profile

Physiology

Disorders

Phenomena

Ultraviolet Rays

Living Beings

Simian virus 40

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Publications

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Daniela T Soltys; Miria Stefanini; Fernanda Cabral; Januário B Cabral-Neto; Tiago A de Souza; Letícia K Lerner; Veridiana Munford; Tiziana Nardo; Clarissa R R Rocha; Alain Sarasin; Carlos F M Menck
Novel XPG (ERCC5) mutations affect DNA repair and cell survival after ultraviolet but not oxidative stress.
Rémi Kazma; Hans E Krokan; Mark Lathrop; John R McLaughlin; Andres Metspalu; Alain Sarasin; Frank Skorpen; Kristjan Välk; Tõnu Vooder; Endre Anderssen; Marie-Claude Babron; Simone Benhamou; Paul Brennan; Maiken B Elvestad; John K Field; Valerie Gaborieau; Emmanuelle Génin; Rayjean J Hung
Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium.
Emilie Warrick; Fulvio Mavilio; Alain Sarasin; Daniela Sartori; Jaime F Angulo; Marie-Françoise Avril; Valérie Bergoglio; Françoise Bernerd; Corinne Chagnoleau; Odile Chevallier; Marcela Del Rio; Marta Garcia; Fernando Larcher; Thierry Magnaldo
Preclinical corrective gene transfer in xeroderma pigmentosum human skin stem cells.

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All Publications

2013: Daniela T Soltys; Miria Stefanini; Fernanda Cabral; Januário B Cabral-Neto; Tiago A de Souza; Letícia K Lerner; Veridiana Munford; Tiziana Nardo; Clarissa R R Rocha; Alain Sarasin; Carlos F M Menck
Novel XPG (ERCC5) mutations affect DNA repair and cell survival after ultraviolet but not oxidative stress.
Human mutation 2013;34(3):481-9.
2012: Rémi Kazma; Hans E Krokan; Mark Lathrop; John R McLaughlin; Andres Metspalu; Alain Sarasin; Frank Skorpen; Kristjan Välk; Tõnu Vooder; Endre Anderssen; Marie-Claude Babron; Simone Benhamou; Paul Brennan; Maiken B Elvestad; John K Field; Valerie Gaborieau; Emmanuelle Génin; Rayjean J Hung
Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium.
Carcinogenesis 2012;33(5):1059-64.
2012: Emilie Warrick; Fulvio Mavilio; Alain Sarasin; Daniela Sartori; Jaime F Angulo; Marie-Françoise Avril; Valérie Bergoglio; Françoise Bernerd; Corinne Chagnoleau; Odile Chevallier; Marcela Del Rio; Marta Garcia; Fernando Larcher; Thierry Magnaldo
Preclinical corrective gene transfer in xeroderma pigmentosum human skin stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(4):798-807.
2012: Alain Sarasin
UVSSA and USP7: new players regulating transcription-coupled nucleotide excision repair in human cells.
Genome medicine 2012;4(5):44.
2012: Maria Carolina S Moraes; Jenifer Saffi; Alain Sarasin; Anne Stary; Mateus H Agnoletto; Helotonio Carvalho; Annabel Quinet de Andrade; Temenouga Guecheva; João A P Henriques; Carlos F M Menck
Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions.
Cancer letters 2012;314(1):108-18.
2011: Daniele G Soares; Alexandre E Escargueil; Carlos M Galmarini; João A P Henriques; Miriana S Machado; Djamila Ouaret; Virginie Poindessous; Céline J Rocca; Alain Sarasin; Annette K Larsen
Trabectedin and its C subunit modified analogue PM01183 attenuate nucleotide excision repair and show activity toward platinum-resistant cells.
Molecular cancer therapeutics 2011;10(8):1481-9.
2010: Céline J Rocca; Virginie Poindessous; Daniele G Soares; Karima El Ouadrani; Alain Sarasin; Eric Guérin; Aimery de Gramont; João Antonio Pêgas Henriques; Alexandre E Escargueil; Annette K Larsen
The NER proteins XPC and CSB, but not ERCC1, regulate the sensitivity to the novel DNA binder S23906: implications for recognition and repair of antitumor alkylators.
Biochemical pharmacology 2010;80(3):335-43.
2010: Alain Sarasin; P Dessen
DNA repair pathways and human metastatic malignant melanoma.
Current molecular medicine 2010;10(4):413-8.
2010: Nadem Soufir; Cecile Ged; Agnes Bourillon; Frederic Austerlitz; Cécile Chemin; Anne Stary; Jacques Armier; Daniele Pham; Khadija Khadir; Joelle Roume; Smail Hadj-Rabia; Bakar Bouadjar; Alain Taieb; Hubert de Verneuil; Hakima Benchiki; Bernard Grandchamp; Alain Sarasin
A prevalent mutation with founder effect in xeroderma pigmentosum group C from north Africa.
The Journal of investigative dermatology 2010;130(6):1537-42.
2009: Damien Brégeon; Paul-Antoine Peignon; Alain Sarasin
Transcriptional mutagenesis induced by 8-oxoguanine in mammalian cells.
PLoS genetics 2009;5(7):e1000577.
2009: Ahmad Faili; Anne Stary; Frédéric Delbos; Sandra Weller; Said Aoufouchi; Alain Sarasin; Jean-Claude Weill; Claude-Agnes Reynaud
A backup role of DNA polymerase kappa in Ig gene hypermutation only takes place in the complete absence of DNA polymerase eta.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(10):6353-9.
2009: Stefan Michiels; Agnès Laplanche; Thomas Boulet; Philippe Dessen; Bertrand Guillonneau; Arnaud Méjean; François Desgrandchamps; Mark Lathrop; Alain Sarasin; Simone Benhamou
Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.
Carcinogenesis 2009;30(5):763-8.
2009: Tiziana Nardo; Roberta Oneda; Graciela Spivak; Bruno Vaz; Laurent Mortier; Pierre Thomas; Donata Orioli; Vincent Laugel; Anne Stary; Philip C Hanawalt; Alain Sarasin; Miria Stefanini
A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(15):6209-14.
2009: Caroline Kannengiesser; Sharon Brookes; Anna Gutierrez del Arroyo; Danielle Pham; Johny Bombled; Michel Barrois; Olivier Mauffret; Marie-Françoise M Avril; Agnès Chompret; Gilbert M Lenoir; Alain Sarasin; Gordon Peters; Brigitte Bressac-de Paillerets
Functional, structural, and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma-prone families or patients.
Human mutation 2009;30(4):564-74.
2008: Tomohisa Nishiwaki; Nobuhiko Kobayashi; Takaaki Iwamoto; Aya Yamamoto; Shigeki Sugiura; Yin-Chang Liu; Alain Sarasin; Yumiko Okahashi; Makito Hirano; Satoshi Ueno; Toshio Mori
Comparative study of nucleotide excision repair defects between XPD-mutated fibroblasts derived from trichothiodystrophy and xeroderma pigmentosum patients.
DNA repair 2008;7(12):1990-8.
2008: Tirzah Braz Petta; Satoshi Nakajima; Anastasia Zlatanou; Emmanuelle Despras; Sophie Couve-Privat; Alexander A Ishchenko; Alain Sarasin; Akira Yasui; Patricia Kannouche
Human DNA polymerase iota protects cells against oxidative stress.
The EMBO journal 2008;27(21):2883-95.
2008: Mathilde Fréchet; E Warrick; C Vioux; O Chevallier; Alain Spatz; Simone Benhamou; Alain Sarasin; Françoise Bernerd; Thierry Magnaldo
Overexpression of matrix metalloproteinase 1 in dermal fibroblasts from DNA repair-deficient/cancer-prone xeroderma pigmentosum group C patients.
Oncogene 2008;27(39):5223-32.
2008: Quentin Gueranger; Anne Stary; Said Aoufouchi; Ahmad Faili; Alain Sarasin; Claude-Agnes Reynaud; Jean-Claude Weill
Role of DNA polymerases eta, iota and zeta in UV resistance and UV-induced mutagenesis in a human cell line.
DNA repair 2008;7(9):1551-62.
2008: Rosa Estela Caseira Cabral; Sophie Queille; Christine Bodemer; Yves de Prost; Januario Bispo Cabral Neto; Alain Sarasin; Leela Daya-Grosjean
Identification of new RECQL4 mutations in Caucasian Rothmund-Thomson patients and analysis of sensitivity to a wide range of genotoxic agents.
Mutation research 2008;643(1-2):41-7.
2008: Vanessa Chiganças; Keronninn M Lima-Bessa; Anne Stary; Carlos F M Menck; Alain Sarasin
Defective transcription/repair factor IIH recruitment to specific UV lesions in trichothiodystrophy syndrome.
Cancer research 2008;68(15):6074-83.
2008: Patrick Danoy; Stefan Michiels; Philippe Dessen; Cécile Pignat; Thomas Boulet; Marion Monet; Christine Bouchardy; Mark Lathrop; Alain Sarasin; Simone Benhamou
Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers.
International journal of cancer. Journal international du cancer 2008;123(2):457-63.
2008: Alain Sarasin; Audrey Kauffmann
Overexpression of DNA repair genes is associated with metastasis: a new hypothesis.
Mutation research 2008;659(1-2):49-55.
2008: Wim J Kleijer; Vincent Laugel; Mark Berneburg; Tiziana Nardo; Heather Fawcett; Alexei Gratchev; Nicolaas G J Jaspers; Alain Sarasin; Miria Stefanini; Alan Lehmann
Incidence of DNA repair deficiency disorders in western Europe: Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy.
DNA repair 2008;7(5):744-50.
2008: Alexandre E Escargueil; Virginie Poindessous; Daniele Grazziotin Soares; Alain Sarasin; Peter R Cook; Annette K Larsen
Influence of irofulven, a transcription-coupled repair-specific antitumor agent, on RNA polymerase activity, stability and dynamics in living mammalian cells.
Journal of cell science 2008;121(Pt 8):1275-83.
2008: Renata M A da Costa; Carolina Quayle; Jaqueline de Fátima Jacysyn; Gustavo Amarante-Mendes; Alain Sarasin; Carlos F M Menck
Resistance to ultraviolet-induced apoptosis in DNA repair deficient growth arrested human fibroblasts is not related to recovery from RNA transcription blockage.
Mutation research 2008;640(1-2):1-7.
2008: Caroline Kannengiesser; Alain Spatz; Stefan Michiels; Alain Eychène; Philippe Dessen; Vladimir Lazar; Véronique Winnepenninckx; Fabienne LESUEUR; Sabine Druillennec; Caroline Robert; Joost J van den Oord; Alain Sarasin; Brigitte Bressac De-Paillerets
Gene expression signature associated with BRAF mutations in human primary cutaneous melanomas.
Molecular oncology 2008;1(4):425-30.
2008: Vincent Laugel; Cecile Dalloz; Anne Stary; Valerie Cormier-Daire; Isabelle Desguerre; Michel Renouil; Alain Fourmaintraux; Renier Velez-Cruz; Jean-Marc Egly; Alain Sarasin; Hélène Dollfus
Deletion of 5' sequences of the CSB gene provides insight into the pathophysiology of Cockayne syndrome.
European journal of human genetics : EJHG 2008;16(3):320-7.
2008: Keronninn Moreno de Lima-Bessa; Melissa Gava Armelini; Vanessa Chiganças; Jacqueline F Jacysyn; Gustavo Amarante-Mendes; Alain Sarasin; Carlos F M Menck
CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells.
DNA repair 2008;7(2):303-12.
2008: Audrey Kauffmann; F Rosselli; V Lazar; Véronique Winnepenninckx; A Mansuet-Lupo; Philippe Dessen; Joost J van den Oord; A Spatz; Alain Sarasin
High expression of DNA repair pathways is associated with metastasis in melanoma patients.
Oncogene 2008;27(5):565-73.
2008: Alain Sarasin
Progress and prospects of xeroderma pigmentosum therapy.
Advances in experimental medicine and biology 2008;637():144-51.
2007: Joost J van den Oord; Alain Sarasin; Véronique Winnepenninckx; Alain Spatz
Expression profiling of melanoma cell lines: in search of a progression-related molecular signature.
Future oncology (London, England) 2007;3(6):609-11.
2007: Valérie Bergoglio; Fernando Larcher; Odile Chevallier-Lagente; Alain BERNHEIM; Olivier Danos; Alain Sarasin; Marcela Del Rio; Thierry Magnaldo
Safe selection of genetically manipulated human primary keratinocytes with very high growth potential using CD24.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(12):2186-93.
2007: Manuela Pastoriza Gallego; Jacques Armier; Alain Sarasin
Transcription through 8-oxoguanine in DNA repair-proficient and Csb(-)/Ogg1(-) DNA repair-deficient mouse embryonic fibroblasts is dependent upon promoter strength and sequence context.
Mutagenesis 2007;22(5):343-51.
2007: Catherine Miquel; S Jacob; Sophie Grandjouan; A Aimé; Jérôme Viguier; Jean-Christophe Sabourin; Alain Sarasin; Alex Duval; Françoise Praz
Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability.
Oncogene 2007;26(40):5919-26.
2007: Daniele Grazziotin Soares; Alexandre E Escargueil; Virginie Poindessous; Alain Sarasin; Aimery de Gramont; Diego Bonatto; João Antonio Pêgas Henriques; Annette K Larsen
Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(32):13062-7.
2007: Stefan Michiels; Patrick Danoy; Philippe Dessen; Alex Bera; Thomas Boulet; Christine Bouchardy; Mark Lathrop; Alain Sarasin; Simone Benhamou
Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers.
Carcinogenesis 2007;28(8):1731-9.
2007: Caroline Kannengiesser; Stéphane Dalle; Marie-Thérèse Leccia; Marie-Françoise Avril; Valérie Bonadona; Agnès Chompret; Christine Lasset; Dominique Leroux; Luc Thomas; Fabienne LESUEUR; Gilbert Lenoir; Alain Sarasin; Brigitte Bressac De-Paillerets
New founder germline mutations of CDKN2A in melanoma-prone families and multiple primary melanoma development in a patient receiving levodopa treatment.
Genes, chromosomes & cancer 2007;46(8):751-60.
2007: Lionel Luron; Marie-Françoise Avril; Alain Sarasin; Leela Daya-Grosjean
Prevalence of human papillomavirus in skin tumors from repair deficient xeroderma pigmentosum patients.
Cancer letters 2007;250(2):213-9.
2007: GOSSELET Fabien; Thierry Magnaldo; Raphaël M Culerrier; Alain Sarasin; Jean-Claude Ehrhart
BMP2 and BMP6 control p57(Kip2) expression and cell growth arrest/terminal differentiation in normal primary human epidermal keratinocytes.
Cellular signalling 2007;19(4):731-9.
2007: Sophie Queille; Lionel Luron; Alain Spatz; Marie-Françoise Avril; Vincent Ribrag; Pierre Duvillard; Christian Hiesse; Alain Sarasin; Jean-Pierre Armand; Leela Daya-Grosjean
Analysis of skin cancer risk factors in immunosuppressed renal transplant patients shows high levels of UV-specific tandem CC to TT mutations of the p53 gene.
Carcinogenesis 2007;28(3):724-31.
2007: Alain Sarasin; Anne Stary
New insights for understanding the transcription-coupled repair pathway.
DNA repair 2007;6(2):265-9.
2007: Elena Botta; Judith Offman; Tiziana Nardo; Roberta Ricotti; Giovanna Zambruno; Daniela Sansone; Paolo Balestri; Anja Raams; Wim J Kleijer; Nicolaas G J Jaspers; Alain Sarasin; Alan Lehmann; Miria Stefanini
Mutations in the C7orf11 (TTDN1) gene in six nonphotosensitive trichothiodystrophy patients: no obvious genotype-phenotype relationships.
Human mutation 2007;28(1):92-6.
2006: Keronninn M Lima-Bessa; Vanessa Chiganças; Anne Stary; Patricia Kannouche; Alain Sarasin; Melissa Gava Armelini; Jacqueline de Fátima Jacysyn; Gustavo Amarante-Mendes; Marila Cordeiro-Stone; James E Cleaver; Carlos F M Menck
Adenovirus mediated transduction of the human DNA polymerase eta cDNA.
DNA repair 2006;5(8):925-34.
2006: Véronique Winnepenninckx; Vladimir Lazar; Stefan Michiels; Philippe Dessen; Marguerite Stas; Soledad R Alonso; Marie-Françoise Avril; Pablo L Ortiz-Romero; Thomas Robert; Ovidiu Balacescu; Alexander M M Eggermont; Gilbert Lenoir; Alain Sarasin; Thomas Tursz; Joost J van den Oord; Alain Spatz
Gene expression profiling of primary cutaneous melanoma and clinical outcome.
Journal of the National Cancer Institute 2006;98(7):472-82.
2006: Mathilde Fréchet; Valérie Bergoglio; Odile Chevallier-Lagente; Alain Sarasin; Thierry Magnaldo
Complementation assays adapted for DNA repair-deficient keratinocytes.
Methods in molecular biology (Clifton, N.J.) 2006;314():9-23.
2005: Florence Le Page; Ely E Kwoh; Anna V Avrutskaya; Alain Gentil; Steven A Leadon; Alain Sarasin; Priscilla K Cooper
Transcription-coupled repair of 8-oxoguanine: requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome.
Cell 2005;123(4):711.
2005: Damien Brégeon; Alain Sarasin
Hypothetical role of RNA damage avoidance in preventing human disease.
Mutation research 2005;577(1-2):293-302.
2005: Denis S F Biard; Emmanuelle Despras; Alain Sarasin; Jaime F Angulo
Development of new EBV-based vectors for stable expression of small interfering RNA to mimick human syndromes: application to NER gene silencing.
Molecular cancer research : MCR 2005;3(9):519-29.
2005: Jérôme Viguier; Valérie Boige; Catherine Miquel; Marc Pocard; Bruno Giraudeau; Jean-Christophe Sabourin; Michel Ducreux; Alain Sarasin; Françoise Praz
ERCC1 codon 118 polymorphism is a predictive factor for the tumor response to oxaliplatin/5-fluorouracil combination chemotherapy in patients with advanced colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6212-7.
2005: Leela Daya-Grosjean; Alain Sarasin
The role of UV induced lesions in skin carcinogenesis: an overview of oncogene and tumor suppressor gene modifications in xeroderma pigmentosum skin tumors.
Mutation research 2005;571(1-2):43-56.
2005: Melissa Gava Armelini; Alysson Renato Muotri; Maria C N Marchetto; Keronninn Moreno de Lima-Bessa; Alain Sarasin; Carlos F M Menck
Restoring DNA repair capacity of cells from three distinct diseases by XPD gene-recombinant adenovirus.
Cancer gene therapy 2005;12(4):389-96.
2005: Renata Maria Augusto da Costa; Lydia Riou; Apuã C M Paquola; Carlos F M Menck; Alain Sarasin
Transcriptional profiles of unirradiated or UV-irradiated human cells expressing either the cancer-prone XPB/CS allele or the noncancer-prone XPB/TTD allele.
Oncogene 2005;24(8):1359-74.
2005: Sandrine Jacob; Catherine Miquel; Alain Sarasin; Françoise Praz
Effects of camptothecin on double-strand break repair by non-homologous end-joining in DNA mismatch repair-deficient human colorectal cancer cell lines.
Nucleic acids research 2005;33(1):106-13.
2005: Françoise Bernerd; Daniel Asselineau; Mathilde Frechet; Alain Sarasin; Thierry Magnaldo
Reconstruction of DNA repair-deficient xeroderma pigmentosum skin in vitro: a model to study hypersensitivity to UV light.
Photochemistry and photobiology 2005;81(1):19-24.
2004: Florence Koeppel; Virginie Poindessous; Vladimir Lazar; Eric Raymond; Alain Sarasin; Annette K Larsen
Irofulven cytotoxicity depends on transcription-coupled nucleotide excision repair and is correlated with XPG expression in solid tumor cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(16):5604-13.
2004: Vanessa Chiganças; Alain Sarasin; Carlos F M Menck
CPD-photolyase adenovirus-mediated gene transfer in normal and DNA-repair-deficient human cells.
Journal of cell science 2004;117(Pt 16):3579-92.
2004: Romina Zanier; Delphine Briot; Jean-Antoine Dugas du Villard; Alain Sarasin; Filippo Rosselli
Fanconi anemia C gene product regulates expression of genes involved in differentiation and inflammation.
Oncogene 2004;23(29):5004-13.
2004: Sophie Couvé-Privat; Marc Le Bret; Elisabeth Traiffort; Sophie Queille; Josée Coulombe; Bakar Bouadjar; Marie-Françoise Avril; Martial Ruat; Alain Sarasin; Leela Daya-Grosjean
Functional analysis of novel sonic hedgehog gene mutations identified in basal cell carcinomas from xeroderma pigmentosum patients.
Cancer research 2004;64(10):3559-65.
2004: Florence Brellier; Claire Marionnet; Odile Chevallier-Lagente; Rune Toftgard; Alain Mauviel; Alain Sarasin; Thierry Magnaldo
Ultraviolet irradiation represses PATCHED gene transcription in human epidermal keratinocytes through an activator protein-1-dependent process.
Cancer research 2004;64(8):2699-704.
2004: Nadem Soufir; Sophie Queille; Karine Mollier; Emeric ROUX; Alain Sarasin; Frank R de Gruijl; Anny Fourtanier; Leela Daya-Grosjean; Nicole Basset-Seguin
INK4a-ARF mutations in skin carcinomas from UV irradiated hairless mice.
Molecular carcinogenesis 2004;39(4):195-8.
2004: Lydia Riou; Eric Eveno; Anneke Van Hoffen; Albert A van Zeeland; Alain Sarasin; Leon H F Mullenders
Differential repair of the two major UV-induced photolesions in trichothiodystrophy fibroblasts.
Cancer research 2004;64(3):889-94.
2004: Thierry Magnaldo; Alain Sarasin
Xeroderma pigmentosum: from symptoms and genetics to gene-based skin therapy.
Cells, tissues, organs 2004;177(3):189-98.
2003: Manuela Pastoriza Gallego; Alain Sarasin
Transcription-coupled repair of 8-oxoguanine in human cells and its deficiency in some DNA repair diseases.
Biochimie 2003;85(11):1073-82.
2003: Helotonio Carvalho; Renata Maria Augusto da Costa; Vanessa Chiganças; Ricardo Weinlich; Gabriela Brumatti; Gustavo Amarante-Mendes; Alain Sarasin; Carlos F M Menck
Effect of cell confluence on ultraviolet light apoptotic responses in DNA repair deficient cells.
Mutation research 2003;544(2-3):159-66.
2003: Alain Sarasin
An overview of the mechanisms of mutagenesis and carcinogenesis.
Mutation research 2003;544(2-3):99-106.
2003: Jean-Claude Ehrhart; GOSSELET Fabien; Raphaël M Culerrier; Alain Sarasin
UVB-induced mutations in human key gatekeeper genes governing signalling pathways and consequences for skin tumourigenesis.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2003;2(8):825-34.
2003: Catherine Arnaudeau-Bégard; Florence Brellier; Odile Chevallier-Lagente; Jan H J Hoeijmakers; Françoise Bernerd; Alain Sarasin; Thierry Magnaldo
Genetic correction of DNA repair-deficient/cancer-prone xeroderma pigmentosum group C keratinocytes.
Human gene therapy 2003;14(10):983-96.
2003: Anne Stary; Patricia Kannouche; Alan Lehmann; Alain Sarasin
Role of DNA polymerase eta in the UV mutation spectrum in human cells.
The Journal of biological chemistry 2003;278(21):18767-75.
2003: Alain Sarasin
Choice between death by senescence or by cancer?
DNA repair 2003;2(4):437-9.
2003: Giuseppina Giglia-Mari; Alain Sarasin
TP53 mutations in human skin cancers.
Human mutation 2003;21(3):217-28.
2003: Christel Masson; Farid MENAA; Ghislaine Pinon-Lataillade; Yveline Frobert; Sylvie Chevillard; J Pablo Radicella; Alain Sarasin; Jaime F Angulo
Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):616-21.
2002: Sophie Couvé-Privat; Bakar Bouadjar; Marie-Françoise Avril; Alain Sarasin; Leela Daya-Grosjean
Significantly high levels of ultraviolet-specific mutations in the smoothened gene in basal cell carcinomas from DNA repair-deficient xeroderma pigmentosum patients.
Cancer research 2002;62(24):7186-9.
2002: Nadem Soufir; M Ribojad; T Magnaldo; O Thibaudeau; Gisèle Delestaing; Leela Daya-Grosjean; Jacqueline Rivet; Alain Sarasin; Nicole Basset-Seguin
Germline and somatic mutations of the INK4a-ARF gene in a xeroderma pigmentosum group C patient.
The Journal of investigative dermatology 2002;119(6):1355-60.
2002: Thierry Magnaldo; Alain Sarasin
Genetic reversion of inherited skin disorders.
Mutation research 2002;509(1-2):211-20.
2002: Christiane Lafarge-Frayssinet; Chantal Martin; Pascale Nguyen Van Binh; Sophie Achard-Ellouk; Huynh Thien Duc; Charles Frayssinet; Georges Cardoso; Genevieve Desauty; Jean-Michel Warnet; Christian Bréchot; Alain Sarasin
Adenovirus-mediated anti insulin-like growth factor I gene transfer for the treatment of hepatocellular carcinoma.
Anticancer research 2002;22(6C):3895-904.
2002: Alysson Renato Muotri; Maria C N Marchetto; Luiz F Zerbini; Towia Libermann; Armando Morais Ventura; Alain Sarasin; Carlos F M Menck
Complementation of the DNA repair deficiency in human xeroderma pigmentosum group a and C cells by recombinant adenovirus-mediated gene transfer.
Human gene therapy 2002;13(15):1833-44.
2002: Anne Stary; Alain Sarasin
Molecular mechanisms of UV-induced mutations as revealed by the study of DNA polymerase eta in human cells.
Research in microbiology 2002;153(7):441-5.
2002: Soraia A C Jorge; Carlos F M Menck; Helmut Sies; Martin R Osborne; David H Phillips; Alain Sarasin; Anne Stary
Mutagenic fingerprint of ozone in human cells.
DNA repair 2002;1(5):369-78.
2002: Bernard C Broughton; Agnes M Cordonnier; Wim J Kleijer; Nicolaas G J Jaspers; Heather Fawcett; Anja Raams; Victor H Garritsen; Anne Stary; Marie-Françoise Avril; François Boudsocq; Chikahide Masutani; Fumio Hanaoka; Robert Fuchs; Alain Sarasin; Alan Lehmann
Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):815-20.
2002: Alain Sarasin; Giuseppina Giglia-Mari
p53 gene mutations in human skin cancers.
Experimental dermatology 2002;11 Suppl 1():44-7.
2002: Florence Le Page; Januario Cabral-Neto; Priscilla K Cooper; Alain Sarasin
Transcription-coupled repair of 8-oxoguanine in human cells.
Methods in enzymology 2002;353():536-47.
2001: Sophie Queille; C Drougard; Alain Sarasin; Leela Daya-Grosjean
Effects of XPD mutations on ultraviolet-induced apoptosis in relation to skin cancer-proneness in repair-deficient syndromes.
The Journal of investigative dermatology 2001;117(5):1162-70.
2001: Bernard C Broughton; Mark Berneburg; Heather Fawcett; EM Taylor; Colin F Arlett; Tiziana Nardo; Miria Stefanini; Emory Menefee; Vera H Price; S Queille; Alain Sarasin; E Bohnert; Jean Krutmann; R Davidson; Kenneth H Kraemer; Alan Lehmann
Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene.
Human molecular genetics 2001;10(22):2539-47.
2001: Françoise Bernerd; Daniel Asselineau; Corinne Vioux; Odile Chevallier-Lagente; B Bouadjar; Alain Sarasin; Thierry Magnaldo
Clues to epidermal cancer proneness revealed by reconstruction of DNA repair-deficient xeroderma pigmentosum skin in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(14):7817-22.
2001: F Lachaise; G Martin; C Drougard; A Perl; M Vuillaume; Maurice Wegnez; Alain Sarasin; Leela Daya-Grosjean
Relationship between posttranslational modification of transaldolase and catalase deficiency in UV-sensitive repair-deficient xeroderma pigmentosum fibroblasts and SV40-transformed human cells.
Free radical biology & medicine 2001;30(12):1365-73.
2001: Alain Spatz; Giuseppina Giglia-Mari; Simone Benhamou; Alain Sarasin
Association between DNA repair-deficiency and high level of p53 mutations in melanoma of Xeroderma pigmentosum.
Cancer research 2001;61(6):2480-6.
2000: Nadem Soufir; Leela Daya-Grosjean; J P Moles; Louis Dubertret; Alain Sarasin; Nicole Basset-Seguin
Association between INK4a-ARF and p53 mutations in skin carcinomas of xeroderma pigmentosum patients.
Journal of the National Cancer Institute 2000;92(22):1841-7.
2000: F Le Page; Voahangy Randrianarison; Didier Marot; J Cabannes; Michel Perricaudet; Jean Feunteun; Alain Sarasin
BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells.
Cancer research 2000;60(19):5548-52.
2000: Patricia Kannouche; Philippe Mauffrey; Ghislaine Pinon-Lataillade; M G Mattei; Alain Sarasin; L Daya-Grosjean; Jaime F Angulo
Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans.
Carcinogenesis 2000;21(9):1701-10.
2000: Alain Gentil; Florence Le Page; J Cadet; Alain Sarasin
Mutation spectra induced by replication of two vicinal oxidative DNA lesions in mammalian cells.
Mutation research 2000;452(1):51-6.
2000: Florence Le Page; E E Kwoh; Anna V Avrutskaya; Alain Gentil; Steven A Leadon; Alain Sarasin; Priscilla K Cooper
Transcription-coupled repair of 8-oxoguanine: requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome.
Cell 2000;101(2):159-71.
2000: S Benhamou; Alain Sarasin
Variability in nucleotide excision repair and cancer risk: a review.
Mutation research 2000;462(2-3):149-58.
1999: Françoise Bernerd; Alain Sarasin; Thierry Magnaldo
Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11329-34.
1999: L Riou; L Zeng; O Chevallier-Lagente; A Stary; O Nikaido; A Taïeb; Geert Weeda; M Mezzina; Alain Sarasin
The relative expression of mutated XPB genes results in xeroderma pigmentosum/Cockayne's syndrome or trichothiodystrophy cellular phenotypes.
Human molecular genetics 1999;8(6):1125-33.
1999: Giuseppina Giglia-Mari; E Bouffet; A Jouvet; H Ohgaki; P Kleihues; Alain Sarasin
Molecular analysis of glioma and skin-tumour alterations in a xeroderma-pigmentosum child.
International journal of cancer. Journal international du cancer 1999;81(3):345-50.
1999: N Bodak; Sophie Queille; Marie-Françoise Avril; Bakar Bouadjar; C Drougard; Alain Sarasin; Leela Daya-Grosjean
High levels of patched gene mutations in basal-cell carcinomas from patients with xeroderma pigmentosum.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(9):5117-22.
1999: A I Otto; L Riou; Claire Marionnet; T Mori; Alain Sarasin; Thierry Magnaldo
Differential behaviors toward ultraviolet A and B radiation of fibroblasts and keratinocytes from normal and DNA-repair-deficient patients.
Cancer research 1999;59(6):1212-8.
1999: Florence Le Page; Alain Gentil; Alain Sarasin
Repair and mutagenesis survey of 8-hydroxyguanine in bacteria and human cells.
Biochimie 1999;81(1-2):147-53.
1998: S Ellouk-Achard; S Djenabi; G A De Oliveira; G Desauty; Huynh Thien Duc; M Zohair; Jerzy Trojan; Jean-Roger Claude; Alain Sarasin; Christiane Lafarge-Frayssinet
Induction of apoptosis in rat hepatocarcinoma cells by expression of IGF-I antisense c-DNA.
Journal of hepatology 1998;29(5):807-18.
1998: Giuseppina Giglia-Mari; Nicolas Dumaz; C Drougard; Marie-Françoise Avril; Leela Daya-Grosjean; Alain Sarasin
p53 mutations in skin and internal tumors of xeroderma pigmentosum patients belonging to the complementation group C.
Cancer research 1998;58(19):4402-9.
1998: Nicolas Dumaz; C Drougard; X Quilliet; M Mezzina; Alain Sarasin; Leela Daya-Grosjean
Recovery of the normal p53 response after UV treatment in DNA repair-deficient fibroblasts by retroviral-mediated correction with the XPD gene.
Carcinogenesis 1998;19(9):1701-4.
1998: Sophie Queille; S Seite; Sylvie Tison; Chantal Medaisko; C Drougard; Anny Fourtanier; Alain Sarasin; Leela Daya-Grosjean
p53 mutations in cutaneous lesions induced in the hairless mouse by a solar ultraviolet light simulator.
Molecular carcinogenesis 1998;22(3):167-74.
1998: Patricia Kannouche; Ghislaine Pinon-Lataillade; Agnes TISSIER; O Chevalier-Lagente; Alain Sarasin; M Mezzina; Jaime F Angulo
The nuclear concentration of kin17, a mouse protein that binds to curved DNA, increases during cell proliferation and after UV irradiation.
Carcinogenesis 1998;19(5):781-9.
1998: F Hoffschir; Leela Daya-Grosjean; Patrice X. PETIT; Silvano Nocentini; B Dutrillaux; Alain Sarasin; M Vuillaume
Low catalase activity in xeroderma pigmentosum fibroblasts and SV40-transformed human cell lines is directly related to decreased intracellular levels of the cofactor, NADPH.
Free radical biology & medicine 1998;24(5):809-16.
1998: F Leprat; Claire Alapetite; Filippo Rosselli; A Ridet; M Schlumberger; Alain Sarasin; H G Suarez; Ethel Moustacchi
Impaired DNA repair as assessed by the "comet" assay in patients with thyroid tumors after a history of radiation therapy: a preliminary study.
International journal of radiation oncology, biology, physics 1998;40(5):1019-26.
1998: Florence Le Page; A Guy; J Cadet; Alain Sarasin; Alain Gentil
Repair and mutagenic potency of 8-oxoG:A and 8-oxoG:C base pairs in mammalian cells.
Nucleic acids research 1998;26(5):1276-81.
1998: C Marionnet; J Armier; Alain Sarasin; A Stary
Cyclobutane pyrimidine dimers are the main mutagenic DNA photoproducts in DNA repair-deficient trichothiodystrophy cells.
Cancer research 1998;58(1):102-8.
1997: X Quilliet; O Chevallier-Lagente; L Zeng; R Calvayrac; M Mezzina; Alain Sarasin; M Vuillaume
Retroviral-mediated correction of DNA repair defect in xeroderma pigmentosum cells is associated with recovery of catalase activity.
Mutation research 1997;385(3):235-42.
1997: Nicolas Dumaz; A Duthu; J C Ehrhart; C Drougard; E Appella; C W Anderson; P May; Alain Sarasin; Leela Daya-Grosjean
Prolonged p53 protein accumulation in trichothiodystrophy fibroblasts dependent on unrepaired pyrimidine dimers on the transcribed strands of cellular genes.
Molecular carcinogenesis 1997;20(4):340-7.
1997: Alain Gentil; Florence Le Page; Alain Sarasin
The consequence of translesional replication of unique UV-induced photoproducts.
Biological chemistry 1997;378(11):1287-92.
1997: L Zeng; X Quilliet; O Chevallier-Lagente; Eric Eveno; Alain Sarasin; M Mezzina
Retrovirus-mediated gene transfer corrects DNA repair defect of xeroderma pigmentosum cells of complementation groups A, B and C.
Gene therapy 1997;4(10):1077-84.
1997: Christiane Lafarge-Frayssinet; Huynh Thien Duc; Charles Frayssinet; Alain Sarasin; D Anthony; Y Guo; Jerzy Trojan
Antisense insulin-like growth factor I transferred into a rat hepatoma cell line inhibits tumorigenesis by modulating major histocompatibility complex I cell surface expression.
Cancer gene therapy 1997;4(5):276-85.
1997: EM Taylor; Bernard C Broughton; Elena Botta; Miria Stefanini; Alain Sarasin; Nicolaas G J Jaspers; Heather Fawcett; SA Harcourt; Colin F Arlett; Alan Lehmann
Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair/transcription gene.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8658-63.
1997: T Stojkovic; Luc Defebvre; X Quilliet; Eric Eveno; Alain Sarasin; M Mezzina; Alain Destée
Neurological manifestations in two related xeroderma pigmentosum group D patients: complications of the late-onset type of the juvenile form.
Movement disorders : official journal of the Movement Disorder Society 1997;12(4):616-9.
1997: C Ahrens; Markus Grewe; Mark Berneburg; Susanne Grether-Beck; X Quilliet; M Mezzina; Alain Sarasin; Alan Lehmann; Colin F Arlett; Jean Krutmann
Photocarcinogenesis and inhibition of intercellular adhesion molecule 1 expression in cells of DNA-repair-defective individuals.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6837-41.
1997: X Veaute; Alain Sarasin
Differential replication of a single N-2-acetylaminofluorene lesion in the leading or lagging strand DNA in a human cell extract.
The Journal of biological chemistry 1997;272(24):15351-7.
1997: Nicolas Dumaz; Henk J van Kranen; Annemieke de Vries; Rob J W Berg; Piet W Wester; Coen F van Kreijl; Alain Sarasin; Leela Daya-Grosjean; Frank R de Gruijl
The role of UV-B light in skin carcinogenesis through the analysis of p53 mutations in squamous cell carcinomas of hairless mice.
Carcinogenesis 1997;18(5):897-904.
1997: Geert Weeda; Eric Eveno; I Donker; Wim Vermeulen; O Chevallier-Lagente; A Taïeb; A Stary; Jan H J Hoeijmakers; M Mezzina; Alain Sarasin
A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy.
American journal of human genetics 1997;60(2):320-9.
1997: Claire Alapetite; A Benoit; Ethel Moustacchi; Alain Sarasin
The comet assay as a repair test for prenatal diagnosis of Xeroderma pigmentosum and trichothiodystrophy.
The Journal of investigative dermatology 1997;108(2):154-9.
1996: C Hera; C Madzak; Alain Sarasin
Use of an infectious Simian virus 40-based shuttle vector to analyse UV-induced mutagenesis in monkey cells.
Mutation research 1996;364(3):235-43.
1996: X Quilliet; O Chevallier-Lagente; Eric Eveno; T Stojkovic; Alain Destée; Alain Sarasin; M Mezzina
Long-term complementation of DNA repair deficient human primary fibroblasts by retroviral transduction of the XPD gene.
Mutation research 1996;364(3):161-9.
1996: C Marionnet; X Quilliet; A Benoit; J Armier; Alain Sarasin; A Stary
Recovery of normal DNA repair and mutagenesis in trichothiodystrophy cells after transduction of the XPD human gene.
Cancer research 1996;56(23):5450-6.
1996: R Rossi; Alessandra Montecucco; L Capolongo; M Mezzina; O Chevallier-Lagente; Alain Sarasin; G Ciarrocchi
The alkylating antitumor drug tallimustine does not induce DNA repair.
Anticancer research 1996;16(6B):3779-83.
1996: Alain Gentil; Florence Le Page; A Margot; Christopher W Lawrence; Angela Borden; Alain Sarasin
Mutagenicity of a unique thymine-thymine dimer or thymine-thymine pyrimidine pyrimidone (6-4) photoproduct in mammalian cells.
Nucleic acids research 1996;24(10):1837-40.
1996: C Robert; B Muel; A Benoit; L Dubertret; Alain Sarasin; A Stary
Cell survival and shuttle vector mutagenesis induced by ultraviolet A and ultraviolet B radiation in a human cell line.
The Journal of investigative dermatology 1996;106(4):721-8.
1996: K Takayama; Edmund P Salazar; Bernard C Broughton; Alan Lehmann; Alain Sarasin; Larry H Thompson; C A Weber
Defects in the DNA repair and transcription gene ERCC2(XPD) in trichothiodystrophy.
American journal of human genetics 1996;58(2):263-70.
1996: A Stary; Alain Sarasin
The genetic basis of xeroderma pigmentosum and trichothiodystrophy syndromes.
Cancer surveys 1996;26():155-71.
1996: B Bouadjar; F Aït-Belkacem; Leela Daya-Grosjean; Alain Sarasin; S L Larbaoui; R Ferhat; M C Cherid; A Bendissari; A Chouiter; K Bouzid; T Henni; A Hafiz; A Allouache; M Ysmail-Dahlouk
[Xeroderma pigmentosum. A study in 40 Algerian patients].
Annales de dermatologie et de vénéréologie 1996;123(5):303-6.
1995: Florence Le Page; A Margot; A P Grollman; Alain Sarasin; Alain Gentil
Mutagenicity of a unique 8-oxoguanine in a human Ha-ras sequence in mammalian cells.
Carcinogenesis 1995;16(11):2779-84.
1995: C Marionnet; A Benoit; S Benhamou; Alain Sarasin; A Stary
Characteristics of UV-induced mutation spectra in human XP-D/ERCC2 gene-mutated xeroderma pigmentosum and trichothiodystrophy cells.
Journal of molecular biology 1995;252(5):550-62.
1995: M Carreau; X Quilliet; Eric Eveno; A Salvetti; O Danos; J M Heard; M Mezzina; Alain Sarasin
Functional retroviral vector for gene therapy of xeroderma pigmentosum group D patients.
Human gene therapy 1995;6(10):1307-15.
1995: Christiane Lafarge-Frayssinet; L Daya-Grosjean; S Estrade; G Frezouls; Alain Sarasin; R Cassingena
Cellular genes possibly involved in the transformation process of the human melanoma cell line XP44 RO (Mel).
Anticancer research 1995;15(4):1205-13.
1995: M Carreau; Eric Eveno; X Quilliet; O Chevalier-Lagente; A Benoit; B Tanganelli; M Stefanini; Wim Vermeulen; Jan H J Hoeijmakers; Alain Sarasin
Development of a new easy complementation assay for DNA repair deficient human syndromes using cloned repair genes.
Carcinogenesis 1995;16(5):1003-9.
1995: Leela Daya-Grosjean; Nicolas Dumaz; Alain Sarasin
The specificity of p53 mutation spectra in sunlight induced human cancers.
Journal of photochemistry and photobiology. B, Biology 1995;28(2):115-24.
1994: Januário Cabral-Neto; R E Cabral; A Margot; Florence Le Page; Alain Sarasin; Alain Gentil
Coding properties of a unique apurinic/apyrimidinic site replicated in mammalian cells.
Journal of molecular biology 1994;240(5):416-20.
1994: M J Pillaire; A Margot; Giuseppe Villani; Alain Sarasin; Martine Defais; Alain Gentil
Mutagenesis in monkey cells of a vector containing a single d(GPG) cis-diamminedichloroplatinum(II) adduct placed on codon 13 of the human H-ras proto-oncogene.
Nucleic acids research 1994;22(13):2519-24.
1994: L Schaeffer; V Moncollin; R Roy; A Staub; M Mezzina; Alain Sarasin; Geert Weeda; Jan H J Hoeijmakers; Jean-Marc Egly
The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor.
The EMBO journal 1994;13(10):2388-92.
1994: Nicolas Dumaz; A Stary; thierry soussi; Leela Daya-Grosjean; Alain Sarasin
Can we predict solar ultraviolet radiation as the causal event in human tumours by analysing the mutation spectra of the p53 gene?
Mutation research 1994;307(1):375-86.
1993: Nicolas Dumaz; C Drougard; Alain Sarasin; Leela Daya-Grosjean
Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10529-33.
1993: M Stefanini; Wim Vermeulen; Geert Weeda; S Giliani; Tiziana Nardo; M Mezzina; Alain Sarasin; J I Harper; C F Arlett; Jan H J Hoeijmakers
A new nucleotide-excision-repair gene associated with the disorder trichothiodystrophy.
American journal of human genetics 1993;53(4):817-21.
1993: F Hoffschir; Monique Vuillaume; Laure Sabatier; Michelle Ricoul; L Daya-Grosjean; S Estrade; R Cassingena; R Calvayrac; Alain Sarasin; Bernard Dutrillaux
Decrease in catalase activity and loss of the 11p chromosome arm in the course of SV40 transformation of human fibroblasts.
Carcinogenesis 1993;14(8):1569-72.
1993: Januário Cabral-Neto; Alain Gentil; R E Cabral; Alain Sarasin
Implication of uracil in spontaneous mutagenesis on a single-stranded shuttle vector replicated in mammalian cells.
Mutation research 1993;288(2):249-55.
1993: C Madzak; J Armier; A Stary; Leela Daya-Grosjean; Alain Sarasin
UV-induced mutations in a shuttle vector replicated in repair deficient trichothiodystrophy cells differ with those in genetically-related cancer prone xeroderma pigmentosum.
Carcinogenesis 1993;14(7):1255-60.
1993: M Stefanini; P Lagomarsini; S Giliani; Tiziana Nardo; Elena Botta; A Peserico; W J Kleijer; Alan Lehmann; Alain Sarasin
Genetic heterogeneity of the excision repair defect associated with trichothiodystrophy.
Carcinogenesis 1993;14(6):1101-5.
1993: Leela Daya-Grosjean; C Robert; C Drougard; H Suarez; Alain Sarasin
High mutation frequency in ras genes of skin tumors isolated from DNA repair deficient xeroderma pigmentosum patients.
Cancer research 1993;53(7):1625-9.
1992: Alain Sarasin; C Blanchet-Bardon; G Renault; A Lehmann; C Arlett; Y Dumez
Prenatal diagnosis in a subset of trichothiodystrophy patients defective in DNA repair.
The British journal of dermatology 1992;127(5):485-91.
1992: Alain Gentil; Januário Cabral-Neto; R Mariage-Samson; A Margot; Jean-Louis Imbach; B Rayner; Alain Sarasin
Mutagenicity of a unique apurinic/apyrimidinic site in mammalian cells.
Journal of molecular biology 1992;227(4):981-4.
1992: A Stary; Carlos F M Menck; Alain Sarasin
Description of a new amplifiable shuttle vector for mutagenesis studies in human cells: application to N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation spectrum.
Mutation research 1992;272(2):101-10.
1992: J B Neto; Alain Gentil; R E Cabral; Alain Sarasin
Mutation spectrum of heat-induced abasic sites on a single-stranded shuttle vector replicated in mammalian cells.
The Journal of biological chemistry 1992;267(27):19718-23.
1992: Vassiliki Pletsa; Alain Gentil; A Margot; J Armier; Soterios A Kyrtopoulos; Alain Sarasin
Mutagenesis by O6 meG residues within codon 12 of the human Ha-ras proto-oncogene in monkey cells.
Nucleic acids research 1992;20(18):4897-901.
1992: A Stary; Alain Sarasin
Molecular analysis of DNA junctions produced by illegitimate recombination in human cells.
Nucleic acids research 1992;20(16):4269-74.
1992: C Madzak; Januário Cabral-Neto; Carlos F M Menck; Alain Sarasin
Spontaneous and ultraviolet-induced mutations on a single-stranded shuttle vector transfected into monkey cells.
Mutation research 1992;274(2):135-45.
1992: A Stary; Alain Sarasin
Simian virus 40 (SV40) large T antigen-dependent amplification of an Epstein-Barr virus-SV40 hybrid shuttle vector integrated into the human HeLa cell genome.
The Journal of general virology 1992;73 ( Pt 7)():1679-85.
1992: D S Biard; A Cordier; Alain Sarasin
Establishment of a human cell line for the detection of demethylating agents.
Experimental cell research 1992;200(2):263-71.
1992: C Madzak; A Margot; Alain Sarasin
Efficient in vivo encapsidation of a shuttle vector into pseudo-simian virus 40 virions using a shuttle virus as helper.
The Journal of general virology 1992;73 ( Pt 6)():1533-6.
1992: D T Ribeiro; F Bourre; Alain Sarasin; P Di Mascio; Carlos F M Menck
DNA synthesis blocking lesions induced by singlet oxygen are targeted to deoxyguanosines.
Nucleic acids research 1992;20(10):2465-9.
1992: Monique Vuillaume; L Daya-Grosjean; P Vincens; J L Pennetier; P Tarroux; A Baret; R Calvayrac; A Taieb; Alain Sarasin
Striking differences in cellular catalase activity between two DNA repair-deficient diseases: xeroderma pigmentosum and trichothiodystrophy.
Carcinogenesis 1992;13(3):321-8.
1992: D S Biard; M R James; A Cordier; Alain Sarasin
Regulation of the Escherichia coli lac operon expressed in human cells.
Biochimica et biophysica acta 1992;1130(1):68-74.
1992: Alain Sarasin; C Robert-Knebelmann; A Stary
[DNA repair and related diseases].
Pathologie-biologie 1992;40(2):169-77.
1992: D T Ribeiro; C Madzak; Alain Sarasin; P Di Mascio; H Sies; Carlos F M Menck
Singlet oxygen induced DNA damage and mutagenicity in a single-stranded SV40-based shuttle vector.
Photochemistry and photobiology 1992;55(1):39-45.
1991: C Madzak; Alain Sarasin
Conversion of a single-stranded simian virus 40 (SV40)-based shuttle vector to its double-stranded form does not require the SV40 T antigen in monkey cells.
The Journal of general virology 1991;72 ( Pt 12)():3091-3.
1991: S Michelin; I Varlet; Cécile Martinerie; Bernard Perbal; Alain Sarasin; H G Suárez
v-myb transformation of Xeroderma pigmentosum human fibroblasts: overexpression of the c-Ha-ras oncogene in the transformed cells.
Experimental cell research 1991;196(2):314-22.
1991: F Bourre; A Lichtenberger; Alain Sarasin
Comparison of spontaneous and ultraviolet-induced mutagenesis on naked SV40 DNA and SV40 virus.
Mutation research 1991;250(1-2):49-53.
1991: C Madzak; Alain Sarasin
Mutation spectrum following transfection of ultraviolet-irradiated single-stranded or double-stranded shuttle vector DNA into monkey cells.
Journal of molecular biology 1991;218(4):667-73.
1991: A Stary; Alain Sarasin
Amplification of Epstein-Barr virus-based shuttle vectors by ultraviolet light in human cells.
Biochimie 1991;73(4):509-14.
1991: A Stary; Alain Sarasin
Ultraviolet-light induces a copy number increase of Epstein-Barr virus-based shuttle vectors.
Progress in clinical and biological research 1991;372():291-9.
1990: Alain Gentil; G Renault; C Madzak; A Margot; Januário Cabral-Neto; Jean-Jacques Vasseur; B Rayner; Jean-Louis Imbach; Alain Sarasin
Mutagenic properties of a unique abasic site in mammalian cells.
Biochemical and biophysical research communications 1990;173(2):704-10.
1990: Alain Gentil; G Renault; A Margot; R Teoule; Alain Sarasin
Mammalian cell processing of a unique uracil residue in simian virus 40 DNA.
Nucleic acids research 1990;18(21):6361-7.
1990: Alain Sarasin; F Bourre; Leela Daya-Grosjean; Alain Gentil; C Madzak; A Stary
Mechanisms and consequences of mutation induction in mammalian cells.
International journal of radiation biology 1990;57(4):665-76.
1990: P Di Mascio; Carlos F M Menck; R G Nigro; Alain Sarasin; Helmut Sies
Singlet molecular oxygen induced mutagenicity in a mammalian SV40-based shuttle vector.
Photochemistry and photobiology 1990;51(3):293-8.
1990: M R James; Alain Sarasin; M Perricaudet; I Joab
Regulated expression of Epstein-Barr virus nuclear antigen 3-encoding gene carried on stable episomal vectors in human cells.
Gene 1990;86(2):233-9.
1990: Bernard C Broughton; Alan Lehmann; S A Harcourt; Colin F Arlett; Alain Sarasin; W J Kleijer; F A Beemer; R Nairn; D L Mitchell
Relationship between pyrimidine dimers, 6-4 photoproducts, repair synthesis and cell survival: studies using cells from patients with trichothiodystrophy.
Mutation research 1990;235(1):33-40.
1990: F Bourre; A Lichtenberger; Alain Sarasin
Analysis of spontaneous and UV-induced mutagenesis on SV40:pyrimidine dimers versus pyrimidine (6-4) pyrimidones and viral infection versus DNA transfection.
Progress in clinical and biological research 1990;340A():327-35.
1990: Carlos F M Menck; M James; A Benoit; Alain Sarasin
Constraints in simian virus 40 (SV40) encapsidation, as determined by SV40-based shuttle viruses.
The Journal of general virology 1990;71 ( Pt 1)():143-50.
1989: Alain Sarasin
[Deficiency in reparases].
Pathologie-biologie 1989;37(9):953-4.
1989: F Bourre; A Benoit; Alain Sarasin
Respective roles of pyrimidine dimer and pyrimidine (6-4) pyrimidone photoproducts in UV mutagenesis of simian virus 40 DNA in mammalian cells.
Journal of virology 1989;63(11):4520-4.
1989: A Stary; M R James; Alain Sarasin
High recombination rate of an Epstein-Barr virus-simian virus 40 hybrid shuttle vector in human cells.
Journal of virology 1989;63(9):3837-43.
1989: Monique Vuillaume; M Best-Belpomme; R Lafont; M Hubert; Y Decroix; Alain Sarasin
Stimulated production of ATP by H2O2 disproportionation in extracts from normal and xeroderma pigmentosum skins, and from normal, xeroderma pigmentosum, ataxia telangiectasia and simian virus 40 transformed cell lines.
Carcinogenesis 1989;10(8):1375-81.
1989: M Mezzina; J Nardelli; S Nocentini; G Remault; Alain Sarasin
DNA ligase activity in human cell lines from normal donors and Bloom's syndrome patients.
Nucleic acids research 1989;17(8):3091-106.
1989: Alain Sarasin
Molecular mechanisms of mutagenesis in mammalian cells: present and future.
Mutation research 1989;220(2-3):51-3.
1989: H G Suarez; Leela Daya-Grosjean; daniel schlaifer; P Nardeux; G Renault; J L Bos; Alain Sarasin
Activated oncogenes in human skin tumors from a repair-deficient syndrome, xeroderma pigmentosum.
Cancer research 1989;49(5):1223-8.
1989: M R James; A Stary; Leela Daya-Grosjean; C Drougard; Alain Sarasin
Comparative study of Epstein-Barr virus and SV40-based shuttle-expression vectors in human repair-deficient cells.
Mutation research 1989;220(2-3):169-85.
1989: Carlos F M Menck; C Madzak; G Renault; A Margot; Alain Sarasin
SV40-based shuttle viruses.
Mutation research 1989;220(2-3):101-6.
1989: C Madzak; Carlos F M Menck; J Armier; Alain Sarasin
Analysis of single-stranded DNA stability and damage-induced strand loss in mammalian cells using SV40-based shuttle vectors.
Journal of molecular biology 1989;205(3):501-9.
1989: M Mezzina; S Nocentini; J Nardelli; G Renault; E Moustacchi; Alain Sarasin
Enhanced deoxyribonuclease activity in human transformed cells and in Bloom's syndrome cells.
Molecular carcinogenesis 1989;2(4):179-83.
1989: Alain Gentil; F Bourre; Alain Sarasin
Carcinogen-induced mutagenesis in the simian virus 40 genome.
Annali dell'Istituto superiore di sanità 1989;25(1):171-6.
1988: M Mezzina; Carlos F M Menck; P Courtin; Alain Sarasin
Replication of simian virus 40 DNA after UV irradiation: evidence of growing fork blockage and single-stranded gaps in daughter strands.
Journal of virology 1988;62(11):4249-58.
1988: H Suarez; Leela Daya-Grosjean; I Varlet; Alain Sarasin
Susceptibility of Xeroderma pigmentosum cells to transformation with oncogenes.
Biochimie 1988;70(7):969-73.
1988: J Armier; M Mezzina; M Leng; Robert Fuchs; Alain Sarasin
N-acetoxy-N-2-acetylaminofluorene-induced damage on SV40 DNA: inhibition of DNA replication and visualization of DNA lesions.
Carcinogenesis 1988;9(5):789-95.
1987: F Bourre; G Renault; Alain Sarasin
Sequence effect on alkali-sensitive sites in UV-irradiated SV40 DNA.
Nucleic acids research 1987;15(21):8861-75.
1987: H G Suàrez; P C Nardeux; Y Andéol; Alain Sarasin
Multiple activated oncogenes in human tumors.
Oncogene research 1987;1(2):201-7.
1987: Leela Daya-Grosjean; M R James; C Drougard; Alain Sarasin
An immortalized xeroderma pigmentosum, group C, cell line which replicates SV40 shuttle vectors.
Mutation research 1987;183(2):185-96.
1987: Carlos F M Menck; Alain Sarasin; M R James
SV40-based Escherichia coli shuttle vectors infectious for monkey cells.
Gene 1987;53(1):21-9.
1987: Carlos F M Menck; M R James; A Gentil; Alain Sarasin
Strategies to analyse mutagenesis in mammalian cells using simian virus 40 or shuttle vectors.
Journal of cell science. Supplement 1987;6():323-31.
1986: Alain Gentil; A Margot; Alain Sarasin
2-(N-acetoxy-N-acetylamino)fluorene mutagenesis in mammalian cells: sequence-specific hot spot.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(24):9556-60.
1986: Monique Vuillaume; R Calvayrac; M Best-Belpomme; P Tarroux; M Hubert; Y Decroix; Alain Sarasin
Deficiency in the catalase activity of xeroderma pigmentosum cell and simian virus 40-transformed human cell extracts.
Cancer research 1986;46(2):538-44.
1985: Alain Sarasin; F Bourre; A Benoit; Leela Daya-Grosjean; Alain Gentil
Molecular analysis of mutagenesis in mammalian cells.
International journal of radiation biology and related studies in physics, chemistry, and medicine 1985;47(5):479-88.
1985: Alain Gentil; Leela Daya-Grosjean; A Margot; Alain Sarasin
Survival and mutagenesis of ultraviolet irradiated simian virus 40 in foetal human fibroblasts.
Biochimie 1985;67(3-4):393-8.
1985: F Bourre; G Renault; P C Seawell; Alain Sarasin
Distribution of ultraviolet-induced lesions in simian virus 40 DNA.
Biochimie 1985;67(3-4):293-9.
1984: Alain Gentil; A Margot; Alain Sarasin
Apurinic sites cause mutations in simian virus 40.
Mutation research 1984;129(2):141-7.
1982: M Mezzina; H G Suarez; R Cassingena; Alain Sarasin
Increased activity of polynucleotide ligase in 5-iodo-2'-deoxyuridine and mitomycin C-pretreated simian virus 40 (SV40)-infected monkey kidney cells.
Nucleic acids research 1982;10(16):5073-84.
1982: M Mezzina; S Nocentini; Alain Sarasin
DNA ligase activity in carcinogen-treated human fibroblasts.
Biochimie 1982;64(8-9):743-8.
1982: Alain Sarasin; F Bourre; A Benoit
Error-prone replication of ultraviolet-irradiated simian virus 40 in carcinogen-treated monkey kidney cells.
Biochimie 1982;64(8-9):815-21.
1982: Alain Gentil; A Margot; Alain Sarasin
Enhanced reactivation and mutagenesis after transfection of carcinogen-treated monkey kidney cells with UV-irradiated simian virus 40 (SV40) DNA.
Biochimie 1982;64(8-9):693-6.