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James Abbruzzese

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Li Donghui; Yeung Sai-Ching J; Hassan Manal M; Konopleva Marina; Abbruzzese James L
Antidiabetic therapies affect risk of pancreatic cancer.
Arumugam Thiruvengadam; Ramachandran Vijaya; Fournier Keith F; Wang Huamin; Marquis Lauren; Abbruzzese James L; Gallick Gary E; Logsdon Craig D; McConkey David J; Choi Woonyoung
Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer.
Li Donghui; Morris Jeffrey S; Liu Jun; Hassan Manal M; Day R Sue; Bondy Melissa L; Abbruzzese James L
Body mass index and risk, age of onset, and survival in patients with pancreatic cancer.

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All Publications

2009: Li Donghui; Yeung Sai-Ching J; Hassan Manal M; Konopleva Marina; Abbruzzese James L
Antidiabetic therapies affect risk of pancreatic cancer.
Gastroenterology 2009;137(2):482-8.
2009: Arumugam Thiruvengadam; Ramachandran Vijaya; Fournier Keith F; Wang Huamin; Marquis Lauren; Abbruzzese James L; Gallick Gary E; Logsdon Craig D; McConkey David J; Choi Woonyoung
Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer.
Cancer research 2009;69(14):5820-8.
2009: Li Donghui; Morris Jeffrey S; Liu Jun; Hassan Manal M; Day R Sue; Bondy Melissa L; Abbruzzese James L
Body mass index and risk, age of onset, and survival in patients with pancreatic cancer.
JAMA : the journal of the American Medical Association 2009;301(24):2553-62.
2009: Overman Michael J; Varadhachary Gauri R; Kopetz Scott; Adinin Rosni; Lin E; Morris Jeffrey S; Eng Cathy; Abbruzzese James L; Wolff Robert A
Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(16):2598-603.
2009: Ng Chaan S; Kodama Yoshihisa; Mullani Nizar A; Barron Bruce J; Wei Wei; Herbst Roy S; Abbruzzese James L; Charnsangavej Chusilp
Tumor blood flow measured by perfusion computed tomography and 15O-labeled water positron emission tomography: a comparison study.
Journal of computer assisted tomography 2009;33(3):460-5.
2009: Shin Sonyo; Asano Takayuki; Yao Yixin; Zhang Ronghua; Claret Francois-Xavier; Korc Murray; Sabapathy Kanaga; Menter David G; Abbruzzese James L; Reddy Shrikanth A G
Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism.
Molecular cancer research : MCR 2009;7(5):745-54.
2009: Hassan Manal M; Kaseb Ahmed; Li Donghui; Patt Yehuda Z; Vauthey Jean-Nicolas; Thomas Melanie B; Curley Steven A; Spitz Margaret R; Sherman Steven I; Abdalla Eddie K; Davila Marta; Lozano Richard D; Hassan Deena M; Chan Wenyaw; Brown Thomas D; Abbruzzese James L
Association between hypothyroidism and hepatocellular carcinoma: a case-control study in the United States.
Hepatology (Baltimore, Md.) 2009;49(5):1563-70.
2009: Kopetz Scott; Lesslie Donald P; Dallas Nikolas A; Park Serk I; Johnson Marjorie; Parikh Nila U; Kim Michael P; Abbruzzese James L; Ellis Lee M; Chandra Joya; Gallick Gary E
Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress.
Cancer research 2009;69(9):3842-9.
2009: Dong Xiaoqun; Jiao Li; Li Yanan; Evans Douglas B; Wang Huamin; Hess Kenneth R; Abbruzzese James L; Li Donghui
Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(10):1592-9.
2009: Katz Matthew H G; Wang Huamin; Fleming Jason B; Sun Charlotte C; Hwang Rosa F; Wolff Robert A; Varadhachary Gauri; Abbruzzese James L; Crane Christopher H; Krishnan Sunil; Vauthey Jean-Nicolas; Abdalla Eddie K; Lee Jeffrey E; Pisters Peter W T; Evans Douglas B
Long-term survival after multidisciplinary management of resected pancreatic adenocarcinoma.
Annals of surgical oncology 2009;16(4):836-47.
2009: Wang Hua; Song Xianzhou; Logsdon Craig; Zhou Guisheng; Evans Douglas B; Abbruzzese James L; Hamilton Stanley R; Tan Tse-Hua; Wang Huamin
Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer.
Cancer research 2009;69(3):1063-70.
2009: Hassan Manal M; Spitz Margret R; Thomas Melanie B; Curley Steven A; Patt Yehuda Z; Vauthey Jean-Nicolas; Glover Katrina Y; Kaseb Ahmed; Lozano Richard D; El-Deeb Adel S; Nguyen Nga T; Wei Steven H; Chan Wenyaw; Abbruzzese James L; Li Donghui
The association of family history of liver cancer with hepatocellular carcinoma: a case-control study in the United States.
Journal of hepatology 2009;50(2):334-41.
2009: Sui X; Shin S; Zhang R; Firozi P F; Yang L; Abbruzzese J L; Reddy S A G
Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells.
Oncogene 2009;28(5):709-20.
2009: Chen Jinyun; Li Donghui; Killary Ann M; Sen Subrata; Amos Christopher I; Evans Douglas B; Abbruzzese James L; Frazier Marsha L
Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation.
Annals of surgical oncology 2009;16(2):431-9.
2009: Li Donghui; Suzuki Hideo; Liu Bingrong; Morris Jeffrey; Liu Jun; Okazaki Taro; Li Yanan; Chang Ping; Abbruzzese James L
DNA repair gene polymorphisms and risk of pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(2):740-6.
2009: Kim Michael P; Evans Douglas B; Wang Huamin; Abbruzzese James L; Fleming Jason B; Gallick Gary E
Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice.
Nature protocols 2009;4(11):1670-80.
2008: Suzuki Hideo; Li Yanan; Dong Xiaoqun; Hassan Manal M; Abbruzzese James L; Li Donghui
Effect of insulin-like growth factor gene polymorphisms alone or in interaction with diabetes on the risk of pancreatic cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(12):3467-73.
2008: Chen Jinyun; Killary Ann M; Sen Subrata; Amos Christopher I; Evans Douglas B; Abbruzzese James L; Frazier Marsha L
Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer.
Cancer letters 2008;272(1):32-9.
2008: Higginbotham Kimberly B; Lozano Richard; Brown Thomas; Patt Yehuda Z; Arima Takashi; Abbruzzese James L; Thomas Melanie B
A phase I/II trial of TAC-101, an oral synthetic retinoid, in patients with advanced hepatocellular carcinoma.
Journal of cancer research and clinical oncology 2008;134(12):1325-35.
2008: Hassan Manal M; Li Donghui; El-Deeb Adel S; Wolff Robert A; Bondy Melissa L; Davila Marta; Abbruzzese James L
Association between hepatitis B virus and pancreatic cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(28):4557-62.
2008: Overman Michael J; Kopetz Scott; Varadhachary Gauri; Fukushima Masakazu; Kuwata Keizo; Mita Akira; Wolff Robert A; Hoff Paulo; Xiong Henry; Abbruzzese James L
Phase I clinical study of three times a day oral administration of TAS-102 in patients with solid tumors.
Cancer investigation 2008;26(8):794-9.
2008: Overman Michael J; Kopetz Scott; Wen Sijin; Hoff Paulo M; Fogelman David; Morris Jeffrey; Abbruzzese James L; Ajani Jaffer A; Wolff Robert A
Chemotherapy with 5-fluorouracil and a platinum compound improves outcomes in metastatic small bowel adenocarcinoma.
Cancer 2008;113(8):2038-45.
2008: Hassan Manal M; Spitz Margaret R; Thomas Melanie B; El-Deeb Adel S; Glover Katrina Y; Nguyen Nga T; Chan Wenyaw; Kaseb Ahmed; Curley Steven A; Vauthey Jean-Nicolas; Ellis Lee M; Abdalla Eddie; Lozano Richard D; Patt Yehuda Z; Brown Thomas D; Abbruzzese James L; Li Donghui
Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women: case-control study.
International journal of cancer. Journal international du cancer 2008;123(8):1883-91.
2008: Overman Michael J; Varadhachary Gauri; Kopetz Scott; Thomas Melanie B; Fukushima Masakazu; Kuwata Keizo; Mita Akira; Wolff Robert A; Hoff Paulo M; Xiong Henry; Abbruzzese James L
Phase 1 study of TAS-102 administered once daily on a 5-day-per-week schedule in patients with solid tumors.
Investigational new drugs 2008;26(5):445-54.
2008: Hoff P M; Kopetz S; Thomas M B; Langleben A; Rinaldi D; Anthony L; Wolff R A; Lassere Y; Abbruzzese J L
A phase II study of UFT with leucovorin administered as a twice daily schedule in the treatment of patients with metastatic colorectal cancer.
British journal of cancer 2008;99(5):722-6.
2008: Wei Yongkun; Xia Weiya; Zhang Zhihong; Liu Jinsong; Wang Huamin; Adsay Nazmi V; Albarracin Constance; Yu Dihua; Abbruzzese James L; Mills Gordon B; Bast Robert C; Hortobagyi Gabriel N; Hung Mien-Chie
Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers.
Molecular carcinogenesis 2008;47(9):701-6.
2008: Evans Douglas B; Varadhachary Gauri R; Crane Christopher H; Sun Charlotte C; Lee Jeffrey E; Pisters Peter W T; Vauthey Jean-Nicolas; Wang Huamin; Cleary Karen R; Staerkel Gregg A; Charnsangavej Chusilp; Lano Elizabeth A; Ho Linus; Lenzi Renato; Abbruzzese James L; Wolff Robert A
Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic head.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(21):3496-502.
2008: Varadhachary Gauri R; Wolff Robert A; Crane Christopher H; Sun Charlotte C; Lee Jeffrey E; Pisters Peter W T; Vauthey Jean-Nicolas; Abdalla Eddie; Wang Huamin; Staerkel Gregg A; Lee Jeffrey H; Ross William A; Tamm Eric P; Bhosale Priya R; Krishnan Sunil; Das Prajnan; Ho Linus; Xiong Henry; Abbruzzese James L; Evans Douglas B
Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic head.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(21):3487-95.
2008: Dhillon Navneet; Aggarwal Bharat B; Newman Robert A; Wolff Robert A; Kunnumakkara Ajaikumar B; Abbruzzese James L; Ng Chaan S; Badmaev Vladimir; Kurzrock Razelle
Phase II trial of curcumin in patients with advanced pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(14):4491-9.
2008: Varadhachary Gauri R; Raber Martin N; Matamoros Aurelio; Abbruzzese James L
Carcinoma of unknown primary with a colon-cancer profile-changing paradigm and emerging definitions.
The lancet oncology 2008;9(6):596-9.
2008: Suzuki Hideo; Morris Jeffrey S; Li Yanan; Doll Mark A; Hein David W; Liu Jun; Jiao Li; Hassan Manal M; Day Rena S; Bondy Melissa L; Abbruzzese James L; Li Donghui
Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer.
Carcinogenesis 2008;29(6):1184-91.
2008: Hwang Rosa F; Wang Huamin; Lara Axbal; Gomez Henry; Chang Tracy; Sieffert Nicole; Moon Younghee; Ram Sabina; Zimmerman Stuart; Lee Jeffrey H; Pisters Peter W T; Tamm Eric P; Fleming Jason B; Abbruzzese James L; Evans Douglas B
Development of an integrated biospecimen bank and multidisciplinary clinical database for pancreatic cancer.
Annals of surgical oncology 2008;15(5):1356-66.
2008: Kopetz Scott; Overman Michael; Chang David Z; Glover Katrina Y; Shureiqi Imad; Wolff Robert A; Abbruzzese James L; Eng Cathy
Systematic survey of therapeutic trials for metastatic colorectal cancer: room for improvement in the critical pathway.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(12):2000-5.
2008: Melisi Davide; Ishiyama Satoshi; Sclabas Guido M; Fleming Jason B; Xia Qianghua; Tortora Giampaolo; Abbruzzese James L; Chiao Paul J
LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis.
Molecular cancer therapeutics 2008;7(4):829-40.
2008: Okazaki Taro; Jiao Li; Chang Ping; Evans Douglas B; Abbruzzese James L; Li Donghui
Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(7):2042-8.
2008: Mullani Nizar A; Herbst Roy S; O'Neil Roger G; Gould K Lance; Barron Bruce J; Abbruzzese James L
Tumor blood flow measured by PET dynamic imaging of first-pass 18F-FDG uptake: a comparison with 15O-labeled water-measured blood flow.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(4):517-23.
2008: Yao James C; Phan Alexandria; Hoff Paulo M; Chen Helen X; Charnsangavej Chusilp; Yeung Sai-Ching J; Hess Kenneth; Ng Chaan; Abbruzzese James L; Ajani Jaffer A
Targeting vascular endothelial growth factor in advanced carcinoid tumor: a random assignment phase II study of depot octreotide with bevacizumab and pegylated interferon alpha-2b.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(8):1316-23.
2008: Jiao Li; Hassan Manal M; Bondy Melissa L; Wolff Robert A; Evans Douglas B; Abbruzzese James L; Li Donghui
XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer.
The American journal of gastroenterology 2008;103(2):360-7.
2007: Hassan Manal M; Bondy Melissa L; Wolff Robert A; Abbruzzese James L; Vauthey Jean-Nicolas; Pisters Peter W; Evans Douglas B; Khan Rabia; Chou Ta-Hsu; Lenzi Renato; Jiao Li; Li Donghui
Risk factors for pancreatic cancer: case-control study.
The American journal of gastroenterology 2007;102(12):2696-707.
2007: Jiao Li; Doll Mark A; Hein David W; Bondy Melissa L; Hassan Manal M; Hixson James E; Abbruzzese James L; Li Donghui
Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(11):2379-86.
2007: Zhu Kuichun; Qin Hong; Cha Soung-Chul; Neelapu Sattva S; Overwijk Willem; Lizee Gregory A; Abbruzzese James L; Hwu Patrick; Radvanyi Laszlo; Kwak Larry W; Chang David Z
Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models.
Vaccine 2007;25(46):7955-61.
2007: Thomas Melanie B; Chadha Romil; Glover Katrina; Wang Xuemei; Morris Jeffrey; Brown Thomas; Rashid Asif; Dancey Janet; Abbruzzese James L
Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma.
Cancer 2007;110(5):1059-67.
2007: Reyes-Gibby Cielito C; Chan Wenyaw; Abbruzzese James L; Xiong Henry Q; Ho Linus; Evans Douglas B; Varadhachary Gauri; Bhat Samrat; Wolff Robert A; Crane Christopher
Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation.
Journal of pain and symptom management 2007;34(3):244-52.
2007: Pentz Rebecca D; Flamm Anne L; Sugarman Jeremy; Cohen Marlene Z; Xu Zhiheng; Herbst Roy S; Abbruzzese James L
Who should go first in trials with scarce agents? The views of potential participants.
IRB 2007;29(4):1-6.
2007: Xie Xiaoming; Xia Weiya; Li Zhongkui; Kuo Hsu-Ping; Liu Yuanfang; Li Zheng; Ding Qingqing; Zhang Su; Spohn Bill; Yang Yan; Wei Yongkun; Lang Jing-Yu; Evans Douglas B; Chiao Paul J; Abbruzzese James L; Hung Mien-Chie
Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models.
Cancer cell 2007;12(1):52-65.
2007: Krishnan Sunil; Rana Vishal; Janjan Nora A; Varadhachary Gauri R; Abbruzzese James L; Das Prajnan; Delclos Marc E; Gould Morris S; Evans Douglas B; Wolff Robert A; Crane Christopher H
Induction chemotherapy selects patients with locally advanced, unresectable pancreatic cancer for optimal benefit from consolidative chemoradiation therapy.
Cancer 2007;110(1):47-55.
2007: Gutierrez-Barrera Angelica M; Menter David G; Abbruzzese James L; Reddy Shrikanth A G
Establishment of three-dimensional cultures of human pancreatic duct epithelial cells.
Biochemical and biophysical research communications 2007;358(3):698-703.
2007: Cohen Marlene Zichi; Slomka Jacquelyn; Pentz Rebecca D; Flamm Anne L; Gold David; Herbst Roy S; Abbruzzese James L
Phase I participants' views of quality of life and trial participation burdens.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2007;15(7):885-90.
2007: Hassan Manal M; Abbruzzese James L; Bondy Melissa L; Wolff Robert A; Vauthey Jean-Nicolas; Pisters Peter W; Evans Douglas B; Khan Rabia; Lenzi Renato; Jiao Li; Li Donghui
Passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer: a case-control study.
Cancer 2007;109(12):2547-56.
2007: Chen Jinyun; Li Donghui; Wei Chongjuan; Sen Subrata; Killary Ann M; Amos Christopher I; Evans Douglas B; Abbruzzese James L; Frazier Marsha L
Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(10):3100-4.
2007: Uwagawa Tadashi; Li Zhongkui; Chang Zhe; Xia Qianghua; Peng Bailu; Sclabas Guido M; Ishiyama Satoshi; Hung Mien-Chie; Evans Douglas B; Abbruzzese James L; Chiao Paul J
Mechanisms of synthetic serine protease inhibitor (FUT-175)-mediated cell death.
Cancer 2007;109(10):2142-53.
2007: Zhu Kuichun; Lizee Gregory; Cano Pedro; Fernando-Vina Marcelo; Ji Baoan; Abbruzzese James L; Hwu Patrick; Radvanyi Laszlo; Chang David Z
HLA-A0201 positive pancreatic cell lines: new findings and discrepancies.
Cancer immunology, immunotherapy : CII 2007;56(5):719-24.
2007: Li Donghui; Day Rena Sue; Bondy Melissa L; Sinha Rashmi; Nguyen Nga T; Evans Douglas B; Abbruzzese James L; Hassan Manal M
Dietary mutagen exposure and risk of pancreatic cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(4):655-61.
2007: Li Donghui; Li Yanan; Jiao Li; Chang David Z; Beinart Garth; Wolff Robert A; Evans Douglas B; Hassan Manal M; Abbruzzese James L
Effects of base excision repair gene polymorphisms on pancreatic cancer survival.
International journal of cancer. Journal international du cancer 2007;120(8):1748-54.
2007: Aloia Thomas A; Lee Jeffrey E; Vauthey Jean-Nicolas; Abdalla Eddie K; Wolff Robert A; Varadhachary Gauri R; Abbruzzese James L; Crane Christopher H; Evans Douglas B; Pisters Peter W T
Delayed recovery after pancreaticoduodenectomy: a major factor impairing the delivery of adjuvant therapy?
Journal of the American College of Surgeons 2007;204(3):347-55.
2007: Jiao Li; Bondy Melissa L; Hassan Manal M; Chang David Z; Abbruzzese James L; Evans Douglas B; Smolensky Michael H; Li Donghui
Glutathione S-transferase gene polymorphisms and risk and survival of pancreatic cancer.
Cancer 2007;109(5):840-8.
2007: Jiao Li; Chang Ping; Firozi Pervez F; Lai Dejian; Abbruzzese James L; Li Donghui
Polymorphisms of phase II xenobiotic-metabolizing and DNA repair genes and in vitro N-ethyl-N-nitrosourea-induced O6-ethylguanine levels in human lymphocytes.
Mutation research 2007;627(2):146-57.
2007: Yao James C; Zhang Jun X; Rashid Asif; Yeung Sai-Ching J; Szklaruk Janio; Hess Kenneth; Xie Keping; Ellis Lee; Abbruzzese James L; Ajani Jaffer A
Clinical and in vitro studies of imatinib in advanced carcinoid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(1):234-40.
2007: Jiao Li; Zhu Jijiang; Hassan Manal M; Evans Douglas B; Abbruzzese James L; Li Donghui
K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking.
Pancreas 2007;34(1):55-62.
2007: Jiao Li; Hassan Manal M; Bondy Melissa L; Abbruzzese James L; Evans Douglas B; Li Donghui
The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.
Cancer letters 2007;245(1-2):61-8.
2006: Krishnan Sunil; Rana Vishal; Janjan Nora A; Abbruzzese James L; Gould Morris S; Das Prajnan; Delclos Marc E; Palla Shana; Guha Sushovan; Varadhachary Gauri; Evans Douglas B; Wolff Robert A; Crane Christopher H
Prognostic factors in patients with unresectable locally advanced pancreatic adenocarcinoma treated with chemoradiation.
Cancer 2006;107(11):2589-96.
2006: Tsuda Naotake; Ishiyama Satoshi; Li Yufeng; Ioannides Constantin G; Abbruzzese James L; Chang David Z
Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(21):6557-64.
2006: Trent Jonathan C; Ramdas Latha; Dupart Jheri; Hunt Kelly; Macapinlac Homer; Taylor Ellen; Hu Limei; Salvado August; Abbruzzese James L; Pollock Raphael; Benjamin Robert S; Zhang Wei
Early effects of imatinib mesylate on the expression of insulin-like growth factor binding protein-3 and positron emission tomography in patients with gastrointestinal stromal tumor.
Cancer 2006;107(8):1898-908.
2006: Khanbolooki Sanaz; Nawrocki Steffan T; Arumugam Thiruvengadam; Andtbacka Robert; Pino Maria S; Kurzrock Razelle; Logsdon Craig D; Abbruzzese James L; McConkey David J
Nuclear factor-kappaB maintains TRAIL resistance in human pancreatic cancer cells.
Molecular cancer therapeutics 2006;5(9):2251-60.
2006: Hong David S; Abbruzzese James L; Bogaard Karla; Lassere Yvonne; Fukushima Masakazu; Mita Akira; Kuwata Keizo; Hoff Paulo M
Phase I study to determine the safety and pharmacokinetics of oral administration of TAS-102 in patients with solid tumors.
Cancer 2006;107(6):1383-90.
2006: Varadhachary Gauri R; Tamm Eric P; Abbruzzese James L; Xiong Henry Q; Crane Christopher H; Wang Huamin; Lee Jeffrey E; Pisters Peter W T; Evans Douglas B; Wolff Robert A
Borderline resectable pancreatic cancer: definitions, management, and role of preoperative therapy.
Annals of surgical oncology 2006;13(8):1035-46.
2006: Hoff Paulo M; Wolff Robert A; Xiong Henry; Jones Dennie; Lin Edward; Eng Cathy; Dutta Ankhi; Bogaard Karla R; Abbruzzese James L
Phase II trial of combined irinotecan and oxaliplatin given every 3 weeks to patients with metastatic colorectal cancer.
Cancer 2006;106(10):2241-6.
2006: Li Zheng; Ding Qingqing; Li Yan; Miller Stephanie A; Abbruzzese James L; Hung Mien-Chie
Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant.
Cancer letters 2006;236(1):58-63.
2006: Pino Maria S; Shrader Marissa; Baker Cheryl H; Cognetti Francesco; Xiong Henry Q; Abbruzzese James L; McConkey David J
Transforming growth factor alpha expression drives constitutive epidermal growth factor receptor pathway activation and sensitivity to gefitinib (Iressa) in human pancreatic cancer cell lines.
Cancer research 2006;66(7):3802-12.
2006: Nawrocki Steffan T; Carew Jennifer S; Pino Maria S; Highshaw Ralph A; Andtbacka Robert H I; Dunner Kenneth; Pal Ashutosh; Bornmann William G; Chiao Paul J; Huang Peng; Xiong Henry; Abbruzzese James L; McConkey David J
Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells.
Cancer research 2006;66(7):3773-81.
2006: Raut Chandrajit P; Cleary Karen R; Staerkel Gregg A; Abbruzzese James L; Wolff Robert A; Lee Jeffrey H; Vauthey Jean-Nicolas; Lee Jeffrey E; Pisters Peter W T; Evans Douglas B
Intraductal papillary mucinous neoplasms of the pancreas: effect of invasion and pancreatic margin status on recurrence and survival.
Annals of surgical oncology 2006;13(4):582-94.
2006: Li Donghui; Frazier Marsha; Evans Douglas B; Hess Kenneth R; Crane Christopher H; Jiao Li; Abbruzzese James L
Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(11):1720-8.
2006: Hess Kenneth R; Varadhachary Gauri R; Taylor Sarah H; Wei Wei; Raber Martin N; Lenzi Renato; Abbruzzese James L
Metastatic patterns in adenocarcinoma.
Cancer 2006;106(7):1624-33.
2006: Li Donghui; Liu Hui; Jiao Li; Chang David Z; Beinart Garth; Wolff Robert A; Evans Douglas B; Hassan Manal M; Abbruzzese James L
Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival.
Cancer research 2006;66(6):3323-30.
2006: Trevino Jose G; Summy Justin M; Lesslie Donald P; Parikh Nila U; Hong David S; Lee Francis Y; Donato Nicholas J; Abbruzzese James L; Baker Cheryl H; Gallick Gary E
Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model.
The American journal of pathology 2006;168(3):962-72.
2006: Crane Christopher H; Ellis Lee M; Abbruzzese James L; Amos Christina; Xiong Henry Q; Ho Linus; Evans Douglas B; Tamm Eric P; Ng Chaan; Pisters Peter W T; Charnsangavej Chusilp; Delclos Marc E; O'Reilly Michael; Lee Jeffrey E; Wolff Robert A
Phase I trial evaluating the safety of bevacizumab with concurrent radiotherapy and capecitabine in locally advanced pancreatic cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(7):1145-51.
2006: Hoff Paulo M; Wolff Robert A; Bogaard Karla; Waldrum Sherry; Abbruzzese James L
A Phase I study of escalating doses of the tyrosine kinase inhibitor semaxanib (SU5416) in combination with irinotecan in patients with advanced colorectal carcinoma.
Japanese journal of clinical oncology 2006;36(2):100-3.
2006: Li Donghui; Jiao Li; Li Yanan; Doll Mark A; Hein David W; Bondy Melissa L; Evans Douglas B; Wolff Robert A; Lenzi Renato; Pisters Peter W; Abbruzzese James L; Hassan Manal M
Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer.
Carcinogenesis 2006;27(1):103-11.
2006: Das Prajnan; Wolff Robert A; Abbruzzese James L; Varadhachary Gauri R; Evans Douglas B; Vauthey Jean Nicolas; Baschnagel Andrew; Delclos Marc E; Krishnan Sunil; Janjan Nora A; Crane Christopher H
Concurrent capecitabine and upper abdominal radiation therapy is well tolerated.
Radiation oncology (London, England) 2006;1():41.
2006: Jiao Li; Bondy Melissa L; Hassan Manal M; Wolff Robert A; Evans Douglas B; Abbruzzese James L; Li Donghui
Selected polymorphisms of DNA repair genes and risk of pancreatic cancer.
Cancer detection and prevention 2006;30(3):284-91.
2006: Xiong Henry Q; Carr Kelli; Abbruzzese James L
Cytotoxic chemotherapy for pancreatic cancer: Advances to date and future directions.
Drugs 2006;66(8):1059-72.
2005: Nawrocki Steffan T; Carew Jennifer S; Pino Maria S; Highshaw Ralph A; Dunner Kenneth; Huang Peng; Abbruzzese James L; McConkey David J
Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis.
Cancer research 2005;65(24):11658-66.
2005: Nawrocki Steffan T; Carew Jennifer S; Dunner Kenneth; Boise Lawrence H; Chiao Paul J; Huang Peng; Abbruzzese James L; McConkey David J
Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells.
Cancer research 2005;65(24):11510-9.
2005: Yokoi Kenji; Sasaki Takamitsu; Bucana Corazon D; Fan Dominic; Baker Cheryl H; Kitadai Yasuhiko; Kuwai Toshio; Abbruzzese James L; Fidler Isaiah J
Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model.
Cancer research 2005;65(22):10371-80.
2005: Thomas Melanie B; Abbruzzese James L
Opportunities for targeted therapies in hepatocellular carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(31):8093-108.
2005: Yokoi Kenji; Shih Li-Chen Nancy; Kobayashi Ryuji; Koomen John; Hawke David; Li Donghui; Hamilton Stanley R; Abbruzzese James L; Coombes Kevin R; Fidler Isaiah J
Serum amyloid A as a tumor marker in sera of nude mice with orthotopic human pancreatic cancer and in plasma of patients with pancreatic cancer.
International journal of oncology 2005;27(5):1361-9.
2005: Zhang Qian; Li Jiang; Deavers Michael; Abbruzzese James L; Ho Linus
The subcellular localization of syntaxin 17 varies among different cell types and is altered in some malignant cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(11):1371-82.
2005: Asano Takayuki; Yao Yixin; Shin Sonyo; McCubrey James; Abbruzzese James L; Reddy Shrikanth A G
Insulin receptor substrate is a mediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells.
Cancer research 2005;65(20):9164-8.
2005: Yokoi Kenji; Kim Sun-Jin; Thaker Premal; Yazici Sertac; Nam Do-Hyun; He Junqin; Sasaki Takamitsu; Chiao Paul J; Sclabas Guido M; Abbruzzese James L; Hamilton Stanley R; Fidler Isaiah J
Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice.
Neoplasia (New York, N.Y.) 2005;7(7):696-704.
2005: Li Donghui; Ahmed Maha; Li Yanan; Jiao Li; Chou Ta-Hsu; Wolff Robert A; Lenzi Renato; Evans Douglas B; Bondy Melissa L; Pisters Peter W; Abbruzzese James L; Hassan Manal M
5,10-Methylenetetrahydrofolate reductase polymorphisms and the risk of pancreatic cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(6):1470-6.
2005: Sclabas Guido M; Uwagawa Tadashi; Schmidt Christian; Hess Kenneth R; Evans Douglas B; Abbruzzese James L; Chiao Paul J
Nuclear factor kappa B activation is a potential target for preventing pancreatic carcinoma by aspirin.
Cancer 2005;103(12):2485-90.
2005: Xiong Henry Q; Plunkett William; Wolff Robert; Du Min; Lenzi Renato; Abbruzzese James L
A pharmacological study of celecoxib and gemcitabine in patients with advanced pancreatic cancer.
Cancer chemotherapy and pharmacology 2005;55(6):559-64.
2005: Koomen John M; Li Donghui; Xiao Lian-chun; Liu Thomas C; Coombes Kevin R; Abbruzzese James; Kobayashi Ryuji
Direct tandem mass spectrometry reveals limitations in protein profiling experiments for plasma biomarker discovery.
Journal of proteome research 2005;4(3):972-81.
2005: Yokoi Kenji; Thaker Premal H; Yazici Sertac; Rebhun Robert R; Nam Do-Hyun; He Junqin; Kim Sun-Jin; Abbruzzese James L; Hamilton Stanley R; Fidler Isaiah J
Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model.
Cancer research 2005;65(9):3716-25.
2005: Zhu Jijiang; Abbruzzese James L; Izzo Julie; Hittelman Walter N; Li Donghui
AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells.
Cancer genetics and cytogenetics 2005;159(1):10-7.
2005: Asano Takayuki; Yao Yixin; Zhu Jijiang; Li Donghui; Abbruzzese James L; Reddy Shrikanth A
The rapamycin analog CCI-779 is a potent inhibitor of pancreatic cancer cell proliferation.
Biochemical and biophysical research communications 2005;331(1):295-302.
2005: Koomen John M; Shih Lichen Nancy; Coombes Kevin R; Li Donghui; Xiao Lian-chun; Fidler Isaiah J; Abbruzzese James L; Kobayashi Ryuji
Plasma protein profiling for diagnosis of pancreatic cancer reveals the presence of host response proteins.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(3):1110-8.
2005: Davis Darren W; Takamori Ryan; Raut Chandrajit P; Xiong Henry Q; Herbst Roy S; Stadler Walter M; Heymach John V; Demetri George D; Rashid Asif; Shen Yu; Wen Sijin; Abbruzzese James L; McConkey David J
Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 1):678-89.
2005: Sclabas Guido M; Fujioka Shuichi; Schmidt Christian; Li Zhongkui; Frederick Wayne A I; Yang Wentao; Yokoi Kenji; Evans Douglas B; Abbruzzese James L; Hess Kenneth R; Zhang Wei; Fidler Isaiah J; Chiao Paul J
Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 1):440-9.
2005: Koomen John M; Zhao Haitao; Li Donghui; Nasser Waleed; Hawke David H; Abbruzzese James L; Baggerly Keith A; Kobayashi Ryuji
Diagnostic protein discovery using liquid chromatography/mass spectrometry for proteolytic peptide targeting.
Rapid communications in mass spectrometry : RCM 2005;19(12):1624-36.
2004: Ebrahimi Behnam; Tucker Susan L; Li Donghui; Abbruzzese James L; Kurzrock Razelle
Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis.
Cancer 2004;101(12):2727-36.
2004: Li Lan; Aggarwal Bharat B; Shishodia Shishir; Abbruzzese James; Kurzrock Razelle
Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis.
Cancer 2004;101(10):2351-62.
2004: Asano Takayuki; Yao Yixin; Zhu Jijiang; Li Donghui; Abbruzzese James L; Reddy Shrikanth A G
The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells.
Oncogene 2004;23(53):8571-80.
2004: Xiong Henry Q; Herbst Roy; Faria Silvana C; Scholz Catherine; Davis Darren; Jackson Edward F; Madden Timothy; McConkey David; Hicks Marshall; Hess Kenneth; Charnsangavej Chusilp Arthur; Abbruzzese James L
A phase I surrogate endpoint study of SU6668 in patients with solid tumors.
Investigational new drugs 2004;22(4):459-66.
2004: Wang Wei; Ke Shi; Wu Qingping; Charnsangavej Chusilp; Gurfinkel Mikhail; Gelovani Juri G; Abbruzzese James L; Sevick-Muraca Eva M; Li Chun
Near-infrared optical imaging of integrin alphavbeta3 in human tumor xenografts.
Molecular imaging : official journal of the Society for Molecular Imaging 2004;3(4):343-51.
2004: Abbruzzese James L; Lippman Scott M
The convergence of cancer prevention and therapy in early-phase clinical drug development.
Cancer cell 2004;6(4):321-6.
2004: Xiong Henry Q; Abbruzzese James L
Adjuvant therapy for pancreatic cancer: current status and future directions.
Surgical oncology clinics of North America 2004;13(4):737-49, xi.
2004: Eng Cathy; Abbruzzese James L
The treatment of colorectal carcinoma: standard chemotherapy and beyond.
Clinical advances in hematology & oncology : H&O 2004;2(9):592-8.
2004: Fujioka Shuichi; Niu Jiangong; Schmidt Christian; Sclabas Guido M; Peng Bailu; Uwagawa Tadashi; Li Zhongkui; Evans Douglas B; Abbruzzese James L; Chiao Paul J
NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity.
Molecular and cellular biology 2004;24(17):7806-19.
2004: Hoff Paulo M; Saad Everardo D; Pazdur Richard; Wolff Robert; Lassere Yvonne; Bogaard Karla R; Abbruzzese James L
Phase I trial of combined irinotecan and oxaliplatin given every three weeks to patients with metastatic colorectal cancer.
Investigational new drugs 2004;22(3):307-13.
2004: Davis Darren W; Inoue Keiji; Dinney Colin P N; Hicklin Daniel J; Abbruzzese James L; McConkey David J
Regional effects of an antivascular endothelial growth factor receptor monoclonal antibody on receptor phosphorylation and apoptosis in human 253J B-V bladder cancer xenografts.
Cancer research 2004;64(13):4601-10.
2004: Xiong Henry Q; Rosenberg Arthur; LoBuglio Albert; Schmidt William; Wolff Robert A; Deutsch John; Needle Michael; Abbruzzese James L
Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(13):2610-6.
2004: Li Zhongkui; Sclabas Guido M; Peng Bailu; Hess Kenneth R; Abbruzzese James L; Evans Douglas B; Chiao Paul J
Overexpression of synuclein-gamma in pancreatic adenocarcinoma.
Cancer 2004;101(1):58-65.
2004: Hoff Paulo M; Pazdur Richard; Lassere Yvonne; Carter Susan; Samid Dvorit; Polito Diane; Abbruzzese James L
Phase II study of capecitabine in patients with fluorouracil-resistant metastatic colorectal carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(11):2078-83.
2004: Fujioka Shuichi; Schmidt Christian; Sclabas Guido M; Li Zhongkui; Pelicano Hélène; Peng Bailu; Yao Alice; Niu Jiangong; Zhang Wei; Evans Douglas B; Abbruzzese James L; Huang Peng; Chiao Paul J
Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB.
The Journal of biological chemistry 2004;279(26):27549-59.
2004: Hoff Paulo M; Ellis Lee M; Abbruzzese James L
Monoclonal antibodies: the foundation of therapy for colorectal cancer in the 21st century?
Oncology (Williston Park, N.Y.) 2004;18(6):736-41; discussion 742, 745-6.
2004: Varadhachary Gauri R; Abbruzzese James L; Lenzi Renato
Diagnostic strategies for unknown primary cancer.
Cancer 2004;100(9):1776-85.
2004: Pino Simona M; Xiong Henry Q; McConkey David; Abbruzzese James L
Novel therapies for pancreatic adenocarcinoma.
Current oncology reports 2004;6(3):199-206.
2004: Pino Simona M; Xiong Henry Q; McConkey David; Abbruzzese James L
Novel therapies for pancreatic adenocarcinoma.
Current gastroenterology reports 2004;6(2):119-25.
2004: Eng Cathy; Abbruzzese James; Minsky Bruce D
Chemotherapy and radiation of anal canal cancer: the first approach.
Surgical oncology clinics of North America 2004;13(2):309-20, viii.
2004: Li Donghui; Xie Keping; Wolff Robert; Abbruzzese James L
Pancreatic cancer.
Lancet 2004;363(9414):1049-57.
2004: Wei Daoyan; Wang Liwei; He Yanjuan; Xiong Henry Q; Abbruzzese James L; Xie Keping
Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity.
Cancer research 2004;64(6):2030-8.
2004: Ke Shi; Wen Xiaoxia; Wu Qing-Ping; Wallace Sidney; Charnsangavej Chusilp; Stachowiak Anne M; Stephens Clifton L; Abbruzzese James L; Podoloff Donald A; Li Chun
Imaging taxane-induced tumor apoptosis using PEGylated, 111In-labeled annexin V.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004;45(1):108-15.
2004: Davis Darren W; Shen Yu; Mullani Nizar A; Wen Sijin; Herbst Roy S; O'Reilly Michael; Abbruzzese James L; McConkey David J
Quantitative analysis of biomarkers defines an optimal biological dose for recombinant human endostatin in primary human tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(1 Pt 1):33-42.
2004: Xiong Henry Q; Abbruzzese James L; Lin Edward; Wang Liwei; Zheng Leizhen; Xie Keping
NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic cancer cells.
International journal of cancer. Journal international du cancer 2004;108(2):181-8.
2004: Jiang Yixing; Wang Liwei; Gong Weida; Wei Daoyan; Le Xiangdong; Yao James; Ajani Jaffer; Abbruzzese James L; Huang Suyun; Xie Keping
A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer.
Clinical & experimental metastasis 2004;21(8):755-64.
2004: Koomen John M; Zhao Haitao; Li Donghui; Abbruzzese James; Baggerly Keith; Kobayashi Ryuji
Diagnostic protein discovery using proteolytic peptide targeting and identification.
Rapid communications in mass spectrometry : RCM 2004;18(21):2537-48.
2003: Schmidt Christian; Peng Bailu; Li Zhongkui; Sclabas Guido M; Fujioka Shuichi; Niu Jiangong; Schmidt-Supprian Marc; Evans Douglas B; Abbruzzese James L; Chiao Paul J
Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation.
Molecular cell 2003;12(5):1287-300.
2003: Xiong Henry Q; Tran Hai T; Madden Timothy L; Newman Robert A; Abbruzzese James L
Phase I and pharmacological study of oral 9-aminocamptothecin colloidal dispersion (NSC 603071) in patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(6):2066-71.
2003: Melichar Bohuslav; Lenzi Renato; Rosenblum Michael; Kudelka Andrzej P; Kavanagh John J; Melicharova Karolina; Templin Stacie; Garcia Michael E; Abbruzzese James L; Freedman Ralph S
Intraperitoneal fluid neopterin, nitrate, and tryptophan after regional administration of interleukin-12.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2003;26(3):270-6.
2003: Nasta Sunita Dwivedy; Hoff Paulo M; George Christopher S; Neubauer Marcus; Cohen Steven C; Abbruzzese James; Winn Rodger; Pazdur Richard M
Phase II study of MGI-114 administered intravenously for 5 days every 28 days to patients with metastatic colorectal cancer.
American journal of clinical oncology 2003;26(2):132-4.
2003: Wang Bailiang; Wei Daoyan; Crum Vanessa E; Richardson Erica L; Xiong Henry H; Luo Yu; Huang Suyun; Abbruzzese James L; Xie Keping
A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis.
Oncogene 2003;22(12):1771-82.
2003: Li Donghui; Zhu Jijiang; Firozi Pervez F; Abbruzzese James L; Evans Douglas B; Cleary Karen; Friess Helmut; Sen Subrata
Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(3):991-7.
2003: Fujioka Shuichi; Sclabas Guido M; Schmidt Christian; Niu Jiangong; Frederick Wayne A; Dong Qiang G; Abbruzzese James L; Evans Douglas B; Baker Cheryl; Chiao Paul J
Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis.
Oncogene 2003;22(9):1365-70.
2003: Wei Daoyan; Le Xiangdong; Zheng Leizhen; Wang Liwei; Frey Jennifer A; Gao Allen C; Peng Zhihai; Huang Suyun; Xiong Henry Q; Abbruzzese James L; Xie Keping
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
Oncogene 2003;22(3):319-29.
2003: Fujioka Shuichi; Sclabas Guido M; Schmidt Christian; Frederick Wayne A; Dong Qiang G; Abbruzzese James L; Evans Douglas B; Baker Cheryl; Chiao Paul J
Function of nuclear factor kappaB in pancreatic cancer metastasis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1):346-54.
2003: Wei Daoyan; Xiong Henry Q; Abbruzzese James L; Xie Keping
Experimental animal models of pancreatic carcinogenesis and metastasis.
International journal of gastrointestinal cancer 2003;33(1):43-60.
2003: Abbruzzese James L
The challenge of pancreatic cancer.
International journal of gastrointestinal cancer 2003;33(1):1-2.
2002: Abbruzzese James L
Past and present treatment of pancreatic adenocarcinoma: chemotherapy as a standard treatment modality.
Seminars in oncology 2002;29(6 Suppl 20):2-8.
2002: Nawrocki Steffan T; Bruns Christiane J; Harbison Matthew T; Bold Richard J; Gotsch Bridget Sweeney; Abbruzzese James L; Elliott Peter; Adams Julian; McConkey David J
Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts.
Molecular cancer therapeutics 2002;1(14):1243-53.
2002: Lenzi Renato; Rosenblum Michael; Verschraegen Claire; Kudelka Andrzej P; Kavanagh John J; Hicks Marshall E; Lang Eric A; Nash Michael A; Levy Lawrence B; Garcia Michael E; Platsoucas Chris D; Abbruzzese James L; Freedman Ralph S
Phase I study of intraperitoneal recombinant human interleukin 12 in patients with Müllerian carcinoma, gastrointestinal primary malignancies, and mesothelioma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(12):3686-95.
2002: Peng Bailu; Fleming Jason B; Breslin Tara; Grau Ana M; Fojioka Shuichi; Abbruzzese James L; Evans Douglas B; Ayers Dan; Wathen Kyle; Wu Tianai; Robertson Kimberly D; Chiao Paul J
Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3628-38.
2002: Hassan Manal M; Hwang Lu-Yu; Hatten Chiq J; Swaim Mark; Li Donghui; Abbruzzese James L; Beasley Palmer; Patt Yehuda Z
Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus.
Hepatology (Baltimore, Md.) 2002;36(5):1206-13.
2002: Xiong Henry Q; Abbruzzese James L
Epidermal growth factor receptor-targeted therapy for pancreatic cancer.
Seminars in oncology 2002;29(5 Suppl 14):31-7.
2002: Saad Everardo D; Kraut Eric H; Hoff Paulo M; Moore Dennis F; Jones Donnah; Pazdur Richard; Abbruzzese James L
Phase II study of dolastatin-10 as first-line treatment for advanced colorectal cancer.
American journal of clinical oncology 2002;25(5):451-3.
2002: Herbst Roy S; Mullani Nizar A; Davis Darren W; Hess Kenneth R; McConkey David J; Charnsangavej Chusilp; O'Reilly Michael S; Kim Hyung-Woo; Baker Cheryl; Roach Jennifer; Ellis Lee M; Rashid Asif; Pluda James; Bucana Corazon; Madden Timothy L; Tran Hai T; Abbruzzese James L
Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(18):3804-14.
2002: Herbst Roy S; Hess Kenneth R; Tran Hai T; Tseng Jennifer E; Mullani Nizar A; Charnsangavej Chusilp; Madden Timothy; Davis Darren W; McConkey David J; O'Reilly Michael S; Ellis Lee M; Pluda James; Hong Waun K; Abbruzzese James L
Phase I study of recombinant human endostatin in patients with advanced solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(18):3792-803.
2002: Pentz Rebecca D; Flamm Anne L; Sugarman Jeremy; Cohen Marlene Z; Daniel Ayers G; Herbst Roy S; Abbruzzese James L
Study of the media's potential influence on prospective research participants' understanding of and motivations for participation in a high-profile phase I trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(18):3785-91.
2002: Dong Qiang G; Sclabas Guido M; Fujioka Shuichi; Schmidt Christian; Peng Bailu; Wu TianAi; Tsao Ming-Sound; Evans Douglas B; Abbruzzese James L; McDonnell Timothy J; Chiao Paul J
The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis.
Oncogene 2002;21(42):6510-9.
2002: Abbruzzese James L
New applications of gemcitabine and future directions in the management of pancreatic cancer.
Cancer 2002;95(4 Suppl):941-5.
2002: Pisters Peter W T; Wolff Robert A; Janjan Nora A; Cleary Karen R; Charnsangavej Chusilp; Crane Christopher N; Lenzi Renato; Vauthey J Nicolas; Lee Jeffrey E; Abbruzzese James L; Evans Douglas B
Preoperative paclitaxel and concurrent rapid-fractionation radiation for resectable pancreatic adenocarcinoma: toxicities, histologic response rates, and event-free outcome.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(10):2537-44.
2002: Crane Christopher H; Abbruzzese James L; Evans Douglas B; Wolff Robert A; Ballo Mathew T; Delclos Marc; Milas Luka; Mason K; Charnsangavej C; Pisters P W T; Lee J E; Lenzi R; Vauthey J N; Wong A B S; Phan T; Nguyen Q; Janjan N A
Is the therapeutic index better with gemcitabine-based chemoradiation than with 5-fluorouracil-based chemoradiation in locally advanced pancreatic cancer?
International journal of radiation oncology, biology, physics 2002;52(5):1293-302.
2002: Saad Everardo D; Abbruzzese James L
Prognostic stratification in UPC: a role for assessing the value of conventional-dose and high-dose chemotherapy for unknown primary carcinoma.
Critical reviews in oncology/hematology 2002;41(2):205-11.
2002: Li Donghui; Firozi Pervez F; Zhang Weiqing; Shen Jianjun; DiGiovanni John; Lau Serrine; Evans Douglas; Friess Helmut; Hassan Manal; Abbruzzese James L
DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer.
Mutation research 2002;513(1-2):37-48.
2002: Lenzi Renato; Yalcin Suayib; Evans Douglas B; Abbruzzese James L
Phase II study of docetaxel in patients with pancreatic cancer previously untreated with cytotoxic chemotherapy.
Cancer investigation 2002;20(4):464-72.
2001: Tseng J E; Glisson B S; Khuri F R; Shin D M; Myers J N; El-Naggar A K; Roach J S; Ginsberg L E; Thall P F; Wang X; Teddy S; Lawhorn K N; Zentgraf R E; Steinhaus G D; Pluda J M; Abbruzzese J L; Hong W K; Herbst R S
Phase II study of the antiangiogenesis agent thalidomide in recurrent or metastatic squamous cell carcinoma of the head and neck.
Cancer 2001;92(9):2364-73.
2001: Kuniyasu H; Abbruzzese J L; Cleary K R; Fidler I J
Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma.
International journal of oncology 2001;19(4):681-5.
2001: Sanfilippo N J; Crane C H; Skibber J; Feig B; Abbruzzese J L; Curley S; Vauthey J N; Ellis L M; Hoff P; Wolff R A; Brown T D; Cleary K; Wong A; Phan T; Janjan N A
T4 rectal cancer treated with preoperative chemoradiation to the posterior pelvis followed by multivisceral resection: patterns of failure and limitations of treatment.
International journal of radiation oncology, biology, physics 2001;51(1):176-83.
2001: Wolff R A; Evans D B; Gravel D M; Lenzi R; Pisters P W; Lee J E; Janjan N A; Charnsangavej C; Abbruzzese J L
Phase I trial of gemcitabine combined with radiation for the treatment of locally advanced pancreatic adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(8):2246-53.
2001: Ho L; Aytac U; Stephens L C; Ohnuma K; Mills G B; McKee K S; Neumann C; LaPushin R; Cabanillas F; Abbruzzese J L; Morimoto C; Dang N H
In vitro and in vivo antitumor effect of the anti-CD26 monoclonal antibody 1F7 on human CD30+ anaplastic large cell T-cell lymphoma Karpas 299.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):2031-40.
2001: Crane C H; Wolff R A; Abbruzzese J L; Evans D B; Milas L; Mason K; Charnsangavej C; Pisters P W; Lee J E; Lenzi R; Lahoti S; Vauthey J N; Janjan N A
Combining gemcitabine with radiation in pancreatic cancer: understanding important variables influencing the therapeutic index.
Seminars in oncology 2001;28(3 Suppl 10):25-33.
2001: Shi Q; Le X; Wang B; Abbruzzese J L; Xiong Q; He Y; Xie K
Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells.
Oncogene 2001;20(28):3751-6.
2001: Shi Q; Le X; Abbruzzese J L; Peng Z; Qian C N; Tang H; Xiong Q; Wang B; Li X C; Xie K
Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma.
Cancer research 2001;61(10):4143-54.
2001: Janjan N A; Crane C; Feig B W; Cleary K; Dubrow R; Curley S; Vauthey J N; Lynch P; Ellis L M; Wolff R; Lenzi R; Abbruzzese J; Pazdur R; Hoff P M; Allen P; Brown T; Skibber J
Improved overall survival among responders to preoperative chemoradiation for locally advanced rectal cancer.
American journal of clinical oncology 2001;24(2):107-12.
2001: Koul D; Yao Y; Abbruzzese J L; Yung W K; Reddy S A
Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway.
The Journal of biological chemistry 2001;276(14):11402-8.
2001: Breslin T M; Hess K R; Harbison D B; Jean M E; Cleary K R; Dackiw A P; Wolff R A; Abbruzzese J L; Janjan N A; Crane C H; Vauthey J N; Lee J E; Pisters P W; Evans D B
Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas: treatment variables and survival duration.
Annals of surgical oncology 2001;8(2):123-32.
2001: Herbst R S; Lee A T; Tran H T; Abbruzzese J L
Clinical studies of angiogenesis inhibitors: the University of Texas MD Anderson Center Trial of Human Endostatin.
Current oncology reports 2001;3(2):131-40.
2001: Wang B; Xiong Q; Shi Q; Le X; Abbruzzese J L; Xie K
Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma.
Cancer research 2001;61(1):71-5.
2001: Crane C H; Janjan N A; Abbruzzese J L; Curley S; Vauthey J; Sawaf H B; Dubrow R; Allen P; Ellis L M; Hoff P; Wolff R A; Lenzi R; Brown T D; Lynch P; Cleary K; Rich T A; Skibber J
Effective pelvic symptom control using initial chemoradiation without colostomy in metastatic rectal cancer.
International journal of radiation oncology, biology, physics 2001;49(1):107-16.
2001: Crane C H; Janjan N A; Evans D B; Wolff R A; Ballo M T; Milas L; Mason K; Charnsangavej C; Pisters P W; Lee J E; Lenzi R; Vauthey J N; Wong A; Phan T; Nguyen Q; Abbruzzese J L
Toxicity and efficacy of concurrent gemcitabine and radiotherapy for locally advanced pancreatic cancer.
International journal of pancreatology : official journal of the International Association of Pancreatology 2001;29(1):9-18.
2001: Wang B; Shi Q; Abbruzzese J L; Xiong Q; Le X; Xie K
A novel, clinically relevant animal model of metastatic pancreatic adenocarcinoma biology and therapy.
International journal of pancreatology : official journal of the International Association of Pancreatology 2001;29(1):37-46.
2001: Xie K; Wang B; Shi Q; Abbruzzese J L; Xiong Q; Le X
Mouse models of metastatic pancreatic adenocarcinoma.
International journal of pancreatology : official journal of the International Association of Pancreatology 2001;29(1):25-35.
2000: Hoff P M; Ellerton J A; Dakhil S R; Winn R J; Abbruzzese J L; Pazdur R
Phase II study of intravenous CI-958 in metastatic colorectal adenocarcinoma.
American journal of clinical oncology 2000;23(6):602-4.
2000: Hoff P M; Janjan N; Saad E D; Skibber J; Crane C; Lassere Y; Cleary K R; Benner S; Randolph J; Abbruzzese J L; Pazdur R
Phase I study of preoperative oral uracil and tegafur plus leucovorin and radiation therapy in rectal cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(20):3529-34.
2000: Pearson A S; Chiao P; Zhang L; Zhang W; Larry L; Katz R L; Evans D B; Abbruzzese J L
The detection of telomerase activity in patients with adenocarcinoma of the pancreas by fine needle aspiration.
International journal of oncology 2000;17(2):381-5.
2000: Bruns C J; Solorzano C C; Harbison M T; Ozawa S; Tsan R; Fan D; Abbruzzese J; Traxler P; Buchdunger E; Radinsky R; Fidler I J
Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma.
Cancer research 2000;60(11):2926-35.
2000: Janjan N A; Crane C N; Feig B W; Cleary K; Dubrow R; Curley S A; Ellis L M; Vauthey J; Lenzi R; Lynch P; Wolff R; Brown T; Pazdur R; Abbruzzese J; Hoff P M; Allen P; Brown B; Skibber J
Prospective trial of preoperative concomitant boost radiotherapy with continuous infusion 5-fluorouracil for locally advanced rectal cancer.
International journal of radiation oncology, biology, physics 2000;47(3):713-8.
2000: Bruns C J; Harbison M T; Davis D W; Portera C A; Tsan R; McConkey D J; Evans D B; Abbruzzese J L; Hicklin D J; Radinsky R
Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1936-48.
2000: Madden T; Tran H T; Beck D; Huie R; Newman R A; Pusztai L; Wright J J; Abbruzzese J L
Novel marine-derived anticancer agents: a phase I clinical, pharmacological, and pharmacodynamic study of dolastatin 10 (NSC 376128) in patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(4):1293-301.
2000: Wolff R A; Chiao P; Lenzi R; Pisters P W; Lee J E; Janjan N A; Crane C H; Evans D B; Abbruzzese J L
Current approaches and future strategies for pancreatic carcinoma.
Investigational new drugs 2000;18(1):43-56.
2000: Pisters P W; Hudec W A; Lee J E; Raijman I; Lahoti S; Janjan N A; Rich T A; Crane C H; Lenzi R; Wolff R A; Abbruzzese J L; Evans D B
Preoperative chemoradiation for patients with pancreatic cancer: toxicity of endobiliary stents.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(4):860-7.
2000: Verschraegen C F; Vincent M; Abbruzzese J L; Siegler D; Kavanagh J J; Loyer E; Kudelka A P; Rubin E
Phase I study of 9-nitro-20(S)-camptothecin in combination with cisplatin for patients with advanced malignancies.
Annals of the New York Academy of Sciences 2000;922():345-8.
1999: Shi Q; Abbruzzese J L; Huang S; Fidler I J; Xiong Q; Xie K
Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(11):3711-21.
1999: Hess K R; Abbruzzese M C; Lenzi R; Raber M N; Abbruzzese J L
Classification and regression tree analysis of 1000 consecutive patients with unknown primary carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(11):3403-10.
1999: Wang W; Abbruzzese J L; Evans D B; Chiao P J
Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA.
Oncogene 1999;18(32):4554-63.
1999: Ravandi F; Rytting M E; Osmon C; Braud E L; Roach R W; Edwards K; Winn R; Abbruzzese J L; Pazdur R
Phase II trial of 5-fluorouracil, folinic acid and recombinant alpha-2a-interferon in patients with advanced colorectal cancer.
Anti-cancer drugs 1999;10(6):519-24.
1999: Janjan N A; Khoo V S; Abbruzzese J; Pazdur R; Dubrow R; Cleary K R; Allen P K; Lynch P M; Glober G; Wolff R; Rich T A; Skibber J
Tumor downstaging and sphincter preservation with preoperative chemoradiation in locally advanced rectal cancer: the M. D. Anderson Cancer Center experience.
International journal of radiation oncology, biology, physics 1999;44(5):1027-38.
1999: Chiao P J; Hunt K K; Grau A M; Abramian A; Fleming J; Zhang W; Breslin T; Abbruzzese J L; Evans D B
Tumor suppressor gene Smad4/DPC4, its downstream target genes, and regulation of cell cycle.
Annals of the New York Academy of Sciences 1999;880():31-7.
1999: Bold R J; Hess K R; Pearson A S; Grau A M; Sinicrope F A; Jennings M; McConkey D J; Bucana C D; Cleary K R; Hallin P A; Chiao P J; Abbruzzese J L; Evans D B
Prognostic factors in resectable pancreatic cancer: p53 and bcl-2.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 1999;3(3):263-77.
1999: Bold R J; Charnsangavej C; Cleary K R; Jennings M; Madray A; Leach S D; Abbruzzese J L; Pisters P W; Lee J E; Evans D B
Major vascular resection as part of pancreaticoduodenectomy for cancer: radiologic, intraoperative, and pathologic analysis.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 1999;3(3):233-43.
1999: Janjan N A; Abbruzzese J; Pazdur R; Khoo V S; Cleary K; Dubrow R; Ajani J; Rich T A; Goswitz M S; Evetts P A; Allen P K; Lynch P M; Skibber J M
Prognostic implications of response to preoperative infusional chemoradiation in locally advanced rectal cancer.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 1999;51(2):153-60.
1999: Wang W; Abbruzzese J L; Evans D B; Larry L; Cleary K R; Chiao P J
The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(1):119-27.
1999: Kuniyasu H; Ellis L M; Evans D B; Abbruzzese J L; Fenoglio C J; Bucana C D; Cleary K R; Tahara E; Fidler I J
Relative expression of E-cadherin and type IV collagenase genes predicts disease outcome in patients with resectable pancreatic carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(1):25-33.
1998: Bouvet M; Bold R J; Lee J; Evans D B; Abbruzzese J L; Chiao P J; McConkey D J; Chandra J; Chada S; Fang B; Roth J A
Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments]
Annals of surgical oncology 1998;5(8):681-8.
1998: Melichar B; Ferrandina G; Verschraegen C F; Loercher A; Abbruzzese J L; Freedman R S
Growth inhibitory effects of aromatic fatty acids on ovarian tumor cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(12):3069-76.
1998: Lee J E; Evans D B; Hickey R C; Sherman S I; Gagel R F; Abbruzzese M C; Abbruzzese J L
Unknown primary cancer presenting as an adrenal mass: frequency and implications for diagnostic evaluation of adrenal incidentalomas.
Surgery 1998;124(6):1115-22.
1998: Pisters P W; Abbruzzese J L; Janjan N A; Cleary K R; Charnsangavej C; Goswitz M S; Rich T A; Raijman I; Wolff R A; Lenzi R; Lee J E; Evans D B
Rapid-fractionation preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for resectable pancreatic adenocarcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(12):3843-50.
1998: Breslin T M; Janjan N A; Lee J E; Pisters P W; Wolff R A; Abbruzzese J L; Evans D B
Neoadjuvant chemoradiation for adenocarcinoma of the pancreas.
Frontiers in bioscience : a journal and virtual library 1998;3():E193-203.
1998: Touroutoglou N; Gravel D; Raber M N; Plunkett W; Abbruzzese J L
Clinical results of a pharmacodynamically-based strategy for higher dosing of gemcitabine in patients with solid tumors.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1998;9(9):1003-8.
1998: Robinson E K; Grau A M; Evans D B; Smid C M; Chiao P J; Abbruzzese J L; Grimm E A
Cell cycle regulation of human pancreatic cancer by tamoxifen.
Annals of surgical oncology 1998;5(4):342-9.
1998: Ayoub J P; Hess K R; Abbruzzese M C; Lenzi R; Raber M N; Abbruzzese J L
Unknown primary tumors metastatic to liver.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(6):2105-12.
1998: Miller A R; Pisters P W; Lee J E; Janjan N A; Abbruzzese J L; Evans D B
Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas.
Hepato-gastroenterology 1998;45(21):624-33.
1998: Lenzi R; Kim E E; Raber M N; Abbruzzese J L
Detection of primary breast cancer presenting as metastatic carcinoma of unknown primary origin by 111In-pentetreotide scan.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1998;9(2):213-6.
1998: Miller A R; Robinson E K; Lee J E; Pisters P W; Chiao P J; Lenzi R L; Abbruzzese J L; Evans D B
Neoadjuvant chemoradiation for adenocarcinoma of the pancreas.
Surgical oncology clinics of North America 1998;7(1):183-97.
1998: Wang M; Abbruzzese J L; Friess H; Hittelman W N; Evans D B; Abbruzzese M C; Chiao P; Li D
DNA adducts in human pancreatic tissues and their potential role in carcinogenesis.
Cancer research 1998;58(1):38-41.
1998: Pazdur R; Medgyesy D C; Winn R J; Dakhil S R; Moore D F; Scalzo A; Hoff P M; Arbuck S G; Abbruzzese J L
Phase II trial of 9-aminocamptothecin (NSC 603071) administered as a 120-hr continuous infusion weekly for three weeks in metastatic colorectal carcinoma.
Investigational new drugs 1998;16(4):341-6.
1998: Evans D B; Pisters P W; Lee J E; Bold R J; Charnsangavej C; Janjan N A; Wolff R A; Abbruzzese J L
Preoperative chemoradiation strategies for localized adenocarcinoma of the pancreas.
Journal of hepato-biliary-pancreatic surgery 1998;5(3):242-50.
1997: Mason K A; Hunter N R; Milas M; Abbruzzese J L; Milas L
Docetaxel enhances tumor radioresponse in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(12 Pt 1):2431-8.
1997: Pazdur R; Meyers C; Diaz-Canton E; Abbruzzese J L; Patt Y; Grove W; Ajani J
Phase II trial of intravenous CI-980 (NSC 370147) in patients with metastatic colorectal carcinoma. Model for prospective evaluation of neurotoxicity.
American journal of clinical oncology 1997;20(6):573-6.
1997: Ferrandina G; Melichar B; Loercher A; Verschraegen C F; Kudelka A P; Edwards C L; Scambia G; Kavanagh J J; Abbruzzese J L; Freedman R S
Growth inhibitory effects of sodium phenylacetate (NSC 3039) on ovarian carcinoma cells in vitro.
Cancer research 1997;57(19):4309-15.
1997: Grau A M; Zhang L; Wang W; Ruan S; Evans D B; Abbruzzese J L; Zhang W; Chiao P J
Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells.
Cancer research 1997;57(18):3929-34.
1997: Pazdur R; Diaz-Canton E; Ballard W P; Bradof J E; Graham S; Arbuck S G; Abbruzzese J L; Winn R
Phase II trial of 9-aminocamptothecin administered as a 72-hour continuous infusion in metastatic colorectal carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(8):2905-9.
1997: Lenzi R; Hess K R; Abbruzzese M C; Raber M N; Ordoñez N G; Abbruzzese J L
Poorly differentiated carcinoma and poorly differentiated adenocarcinoma of unknown origin: favorable subsets of patients with unknown-primary carcinoma?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(5):2056-66.
1997: Spitz F R; Abbruzzese J L; Lee J E; Pisters P W; Lowy A M; Fenoglio C J; Cleary K R; Janjan N A; Goswitz M S; Rich T A; Evans D B
Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticoduodenectomy for adenocarcinoma of the pancreas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(3):928-37.
1997: Evans D B; Lee J E; Pisters P W; Charnsangavej C; Ellis L M; Chiao P J; Lenzi R; Abbruzzese J L
Advances in the diagnosis and treatment of adenocarcinoma of the pancreas.
Cancer treatment and research 1997;90():109-25.
1996: Sinicrope F A; Evans D B; Leach S D; Cleary K R; Fenoglio C J; Lee J J; Abbruzzese J L
bcl-2 and p53 expression in resectable pancreatic adenocarcinomas: association with clinical outcome.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(12):2015-22.
1996: Abbruzzese J L
Phase I studies with the novel nucleoside analog gemcitabine.
Seminars in oncology 1996;23(5 Suppl 10):25-31.
1996: Beran M; Kantarjian H; O'Brien S; Koller C; al-Bitar M; Arbuck S; Pierce S; Moore M; Abbruzzese J L; Andreeff M; Keating M; Estey E
Topotecan, a topoisomerase I inhibitor, is active in the treatment of myelodysplastic syndrome and chronic myelomonocytic leukemia.
Blood 1996;88(7):2473-9.
1996: Abbruzzese J L; Madden T; Sugarman S M; Ellis A L; Loughlin S; Hess K R; Newman R A; Zwelling L A; Raber M N
Phase I clinical and plasma and cellular pharmacological study of topotecan without and with granulocyte colony-stimulating factor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(9):1489-97.
1996: Staley C A; Cleary K R; Abbruzzese J L; Lee J E; Ames F C; Fenoglio C J; Evans D B
The need for standardized pathologic staging of pancreaticoduodenectomy specimens.
Pancreas 1996;12(4):373-80.
1996: Evans D B; Frazier M L; Charnsangavej C; Katz R L; Larry L; Abbruzzese J L
Molecular diagnosis of exocrine pancreatic cancer using a percutaneous technique.
Annals of surgical oncology 1996;3(3):241-6.
1996: Abbruzzese J L; Abbruzzese M C; Lenzi R; Raber M N; Hess K R
Are time or intensity factors important to the definition of metastases of unknown origin?
Journal of the National Cancer Institute 1996;88(7):462-3.
1996: Staley C A; Lee J E; Cleary K R; Abbruzzese J L; Fenoglio C J; Rich T A; Evans D B
Preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for adenocarcinoma of the pancreatic head.
American journal of surgery 1996;171(1):118-24; discussion 124-5.
1996: Pazdur R; Meropol N J; Casper E S; Fuchs C; Douglass H O; Vincent M; Abbruzzese J L
Phase II trial of ZD1694 (Tomudex) in patients with advanced pancreatic cancer.
Investigational new drugs 1996;13(4):355-8.
1995: Moore D F; Pazdur R; Sugarman S; Jones D; Lippman S M; Bready B; Abbruzzese J L
Pilot phase II trial of 13-cis-retinoic acid and interferon-alpha combination therapy for advanced pancreatic adenocarcinoma.
American journal of clinical oncology 1995;18(6):525-7.
1995: Jones D V; Winn R J; Brown B W; Levy L B; Pugh R P; Wade J L; Gross H M; Pendergrass K B; Levin B; Abbruzzese J L
Randomized phase III study of 5-fluorouracil plus high dose folinic acid versus 5-fluorouracil plus folinic acid plus methyl-lomustine for patients with advanced colorectal cancer.
Cancer 1995;76(10):1709-14.
1995: Evans D B; Abbruzzese J L; Cleary K R; Buchholz D J; Fenoglio C J; Collier C; Rich T A
Preoperative chemoradiation for adenocarcinoma of the pancreas: excessive toxicity of prophylactic hepatic irradiation.
International journal of radiation oncology, biology, physics 1995;33(4):913-8.
1995: Evans O B; Abbruzzese J L; Cleary K R; Lee J E; Buchholz D J; Rich T A
Rapid-fractionation pre-operative chemoradiation for malignant periampullary neoplasms.
Journal of the Royal College of Surgeons of Edinburgh 1995;40(5):319-23.
1995: Pazdur R; Bready B; Ajani J A; Abbruzzese J L; Markowitz A; Sugarman S; Jones D; Levin B
Phase II trial of isotretinoin and recombinant interferon alfa-2a in metastatic colorectal carcinoma.
American journal of clinical oncology 1995;18(5):436-8.
1995: Leach S D; Rose J A; Lowy A M; Lee J E; Charnsangavej C; Abbruzzese J L; Katz R L; Evans D B
Significance of peritoneal cytology in patients with potentially resectable adenocarcinoma of the pancreatic head.
Surgery 1995;118(3):472-8.
1995: Abbruzzese J L; Abbruzzese M C; Lenzi R; Hess K R; Raber M N
Analysis of a diagnostic strategy for patients with suspected tumors of unknown origin.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1995;13(8):2094-103.
1994: Pazdur R; Lassere Y; Rhodes V; Ajani J A; Sugarman S M; Patt Y Z; Jones D V; Markowitz A B; Abbruzzese J L; Bready B
Phase II trial of uracil and tegafur plus oral leucovorin: an effective oral regimen in the treatment of metastatic colorectal carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(11):2296-300.
1994: Abbruzzese J L; Abbruzzese M C; Hess K R; Raber M N; Lenzi R; Frost P
Unknown primary carcinoma: natural history and prognostic factors in 657 consecutive patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(6):1272-80.
1994: Pazdur R; Lassere Y; Soh L T; Ajani J A; Bready B; Soo E; Sugarman S; Patt Y; Abbruzzese J L; Levin B
Phase II trial of docetaxel (Taxotere) in metastatic colorectal carcinoma.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1994;5(5):468-70.
1994: Hubbard K P; Roehm J O; Abbruzzese J L
The Bird's Nest Filter. An alternative to long-term oral anticoagulation in patients with advanced malignancies.
American journal of clinical oncology 1994;17(2):115-7.
1994: Moore D F; Pazdur R; Abbruzzese J L; Ajani J A; Dubovsky D W; Wade J L; Belt R J; Mangold C; Bready B; Winn R J
Phase II trial of edatrexate in patients with advanced pancreatic adenocarcinoma.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1994;5(3):286-7.
1994: Fuhrman G M; Charnsangavej C; Abbruzzese J L; Cleary K R; Martin R G; Fenoglio C J; Evans D B
Thin-section contrast-enhanced computed tomography accurately predicts the resectability of malignant pancreatic neoplasms.
American journal of surgery 1994;167(1):104-11; discussion 111-3.
1994: Lenzi R; Frost P; Abbruzzese J L
Modulation of cisplatin resistance by 2'-deoxy-5-azacytidine in human ovarian tumor cell lines.
Anticancer research 1994;14(1A):247-51.
1994: Moore D F; Pazdur R; Abbruzzese J L
Phase II trial of intravenous melphalan in advanced colorectal carcinoma.
Investigational new drugs 1994;12(2):133-6.
1993: Jones D V; Patt Y Z; Ajani J A; Abbruzzese J; Carrasco C H; Charnsangavej C; Levin B; Wallace S
A phase I-II trial of mitoxantrone by hepatic arterial infusion in patients with hepatocellular carcinoma or colorectal carcinoma metastatic to the liver.
Cancer 1993;72(9):2560-3.
1993: Bar-Eli M; Abbruzzese J L; Lee-Jackson D; Frost P
p53 gene mutation spectrum in human unknown primary tumors.
Anticancer research 1993;13(5A):1619-23.
1993: Abbruzzese J L; Lenzi R; Raber M N; Pathak S; Frost P
The biology of unknown primary tumors.
Seminars in oncology 1993;20(3):238-43.
1993: Ajani J A; Abbruzzese J L; Markowitz A B; Patt Y Z; Daugherty K
Phase II study of etoposide and alpha-interferon in patients with advanced measurable colorectal carcinoma.
Investigational new drugs 1993;11(1):67-9.
1993: Ellerhorst J A; Frost P; Abbruzzese J L; Newman R A; Chernajovsky Y
2'-deoxy-5-azacytidine increases binding of cisplatin to DNA by a mechanism independent of DNA hypomethylation.
British journal of cancer 1993;67(2):209-15.
1993: Lenzi R; Raber M N; Frost P; Schmidt S; Abbruzzese J L
Phase II study of cisplatin, 5-fluorouracil and folinic acid in patients with carcinoma of unknown primary origin.
European journal of cancer (Oxford, England : 1990) 1993;29A(11):1634.
1992: Hubbard K P; Pazdur R; Ajani J A; Braud E; Blaustein A; King M; Llenado-Lee M; Winn R; Levin B; Abbruzzese J L
Phase II evaluation of iproplatin in patients with advanced gastric and pancreatic cancer.
American journal of clinical oncology 1992;15(6):524-7.
1992: Moore D F; Pazdur R; Daugherty K; Tarassoff P; Abbruzzese J L
Phase II study of gemcitabine in advanced colorectal adenocarcinoma.
Investigational new drugs 1992;10(4):323-5.
1992: Pazdur R; Ajani J J; Abbruzzese J L; Belt R J; Dakhil S R; Dubovsky D; Graham S; Pilat S; Winn R; Levin B
Phase II evaluation of fluorouracil and recombinant alpha-2a-interferon in previously untreated patients with pancreatic adenocarcinoma.
Cancer 1992;70(8):2073-6.
1992: Jones D V; Ajani J A; Blackburn R; Daugherty K; Levin B; Patt Y Z; Abbruzzese J L
Phase II study of didemnin B in advanced colorectal cancer.
Investigational new drugs 1992;10(3):211-3.
1992: Hubbard K P; Daugherty K; Ajani J A; Pazdur R; Levin B; Abbruzzese J L
Phase II trial of fazarabine in advanced colorectal carcinoma.
Investigational new drugs 1992;10(1):39-42.
1992: Anzai H; Frost P; Abbruzzese J L
Synergistic cytotoxicity with 2'-deoxy-5-azacytidine and topotecan in vitro and in vivo.
Cancer research 1992;52(8):2180-5.
1992: Abbruzzese J L; Gholson C F; Daugherty K; Larson E; DuBrow R; Berlin R; Levin B
A pilot clinical trial of the cholecystokinin receptor antagonist MK-329 in patients with advanced pancreatic cancer.
Pancreas 1992;7(2):165-71.
1992: Abbruzzese J L; Frost P
Studies on the mechanism of the synergistic interaction between 2'-deoxy-5-azacytidine and cisplatin.
Cancer chemotherapy and pharmacology 1992;30(1):31-6.
1991: Ajani J A; Pazdur R; Winn R J; Abbruzzese J L; Levin B; Belt R; Young J; Patt Y Z; Krakoff I H
Phase II study of intravenous 6-thioguanine in patients with advanced carcinoma of the pancreas.
Investigational new drugs 1991;9(4):369-71.
1991: Linke K; Pazdur R; Abbruzzese J L; Ajani J A; Winn R; Bradof J E; Daugherty K; Levin B
Phase II study of amonafide in advanced pancreatic adenocarcinoma.
Investigational new drugs 1991;9(4):353-6.
1991: Lee N K; Byers R M; Abbruzzese J L; Wolf P
Metastatic adenocarcinoma to the neck from an unknown primary source.
American journal of surgery 1991;162(4):306-9.
1991: Ajani J A; Pazdur R; Winn R J; Abbruzzese J L; Levin B; Wiseman C; Lenado-Lee M A; Patt Y Z; Krakoff I H
Phase II study of intravenous 6-thioguanine in patients with advanced gastric carcinoma.
Investigational new drugs 1991;9(3):257-9.
1991: Raber M N; Faintuch J; Abbruzzese J L; Sumrall C; Frost P
Continuous infusion 5-fluorouracil, etoposide and cis-diamminedichloroplatinum in patients with metastatic carcinoma of unknown primary origin.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1991;2(7):519-20.
1991: Abbruzzese J L; Grunewald R; Weeks E A; Gravel D; Adams T; Nowak B; Mineishi S; Tarassoff P; Satterlee W; Raber M N
A phase I clinical, plasma, and cellular pharmacology study of gemcitabine.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1991;9(3):491-8.
1991: Grunewald R; Abbruzzese J L; Tarassoff P; Plunkett W
Saturation of 2',2'-difluorodeoxycytidine 5'-triphosphate accumulation by mononuclear cells during a phase I trial of gemcitabine.
Cancer chemotherapy and pharmacology 1991;27(4):258-62.
1990: Grunewald R; Kantarjian H; Keating M J; Abbruzzese J; Tarassoff P; Plunkett W
Pharmacologically directed design of the dose rate and schedule of 2',2'-difluorodeoxycytidine (Gemcitabine) administration in leukemia.
Cancer research 1990;50(21):6823-6.
1990: Abbruzzese J L; Levin B; Ajani J A; Faintuch J S; Pazdur R; Saks S; Edwards C; Gutterman J U
A phase II trial of recombinant human interferon-gamma and recombinant tumor necrosis factor in patients with advanced gastrointestinal malignancies: results of a trial terminated by excessive toxicity.
Journal of biological response modifiers 1990;9(5):522-7.
1990: Frost P; Abbruzzese J L; Hunt B; Lee D; Ellis M
Synergistic cytotoxicity using 2'-deoxy-5-azacytidine and cisplatin or 4-hydroperoxycyclophosphamide with human tumor cells.
Cancer research 1990;50(15):4572-7.
1990: Ajani J A; Roth J A; Ryan B; McMurtrey M; Rich T A; Jackson D E; Abbruzzese J L; Levin B; DeCaro L; Mountain C
Evaluation of pre- and postoperative chemotherapy for resectable adenocarcinoma of the esophagus or gastroesophageal junction.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1990;8(7):1231-8.
1990: Abbruzzese J L; Amato R; Schmidt S; Raber M N; Frost P
Phase I clinical trial of cisplatin given i.v. with 5-fluorouracil and high-dose folinic acid.
Cancer chemotherapy and pharmacology 1990;26(3):159-62.
1990: Ajani J A; Abbruzzese J L; Faintuch J S; Patt Y Z; Boman B M; Jackson D E; Levin B; Krakoff I H
A phase II study of trimetrexate therapy for metastatic colorectal carcinoma.
Cancer investigation 1990;8(6):619-21.
1990: Ajani J A; Ota D M; Grossie V B; Abbruzzese J L; Faintuch J S; Patt Y Z; Jackson D E; Levin B; Nishioka K
Evaluation of continuous-infusion alpha-difluoromethylornithine therapy for colorectal carcinoma.
Cancer chemotherapy and pharmacology 1990;26(3):223-6.
1989: Abbruzzese J L; Weeks A; Raber M N; Gravel D; DuBrow R A; Levin B; Grem J; Chun H G
Phase I trial of semustine plus weekly fluorouracil and high-dose leucovorin calcium in patients with advanced colorectal cancer.
Journal of the National Cancer Institute 1989;81(23):1840-2.
1989: Abbruzzese J L; Schmidt S; Raber M N; Levy J K; Castellanos A M; Legha S S; Krakoff I H
Phase I trial of 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-methyluracil (FMAU) terminated by severe neurologic toxicity.
Investigational new drugs 1989;7(2-3):195-201.
1989: Abbruzzese J L; Levin B; Ajani J A; Faintuch J S; Saks S; Patt Y Z; Edwards C; Ende K; Gutterman J U
Phase I trial of recombinant human gamma-interferon and recombinant human tumor necrosis factor in patients with advanced gastrointestinal cancer.
Cancer research 1989;49(14):4057-61.
1989: Ajani J A; Rios A A; Ende K; Abbruzzese J L; Edwards C; Faintuch J S; Saks S; Gutterman J U; Levin B
Phase I and II studies of the combination of recombinant human interferon-gamma and 5-fluorouracil in patients with advanced colorectal carcinoma.
Journal of biological response modifiers 1989;8(2):140-6.
1989: Abbruzzese J L; Levin B
Treatment of advanced colorectal cancer.
Hematology/oncology clinics of North America 1989;3(1):135-53.
1989: Ajani J A; Goudeau P; Levin B; Faintuch J S; Abbruzzese J L; Boman B M; Kanojia M D
Phase II study of adriamycin with sequential methotrexate and 5-fluorouracil (AMF) in gastric carcinoma.
Cancer chemotherapy and pharmacology 1989;24(1):41-4.
1988: Ajani J A; Abbruzzese J L; Goudeau P; Faintuch J S; Yeomans A C; Boman B M; Nicaise C; Levin B
Ifosfamide and mesna: marginally active in patients with advanced carcinoma of the pancreas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1988;6(11):1703-7.
1988: Ajani J A; Abbruzzese J L; Faintuch J S; Blackburn R; Levin B; Boman B M
Phase II study of fludarabine phosphate in patients with advanced colorectal carcinoma.
Investigational new drugs 1988;6(1):47-50.

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