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Robert Sarisky

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Reginald Clayton; Asa Ohagen; Francois Nicol; Alfred M Del Vecchio; Tim H M Jonckers; Olivia Goethals; Marnix Van Loock; Lieve Michiels; John Grigsby; Zheng Xu; Yuan Peng Zhang; Lester L Gutshall; Mark Cunningham; Haiyan Jiang; Sharon Bola; Robert T Sarisky; Kurt Hertogs
Sustained and specific in vitro inhibition of HIV-1 replication by a protease inhibitor encapsulated in gp120-targeted liposomes.
Lynne Murray; Darryl A Knight; Laura McAlonan; Rochelle Argentieri; Amrita Joshi; Furquan Shaheen; Mark Cunningham; Lena Alexopolou; Richard A Flavell; Robert T Sarisky; Cory M Hogaboam
Deleterious role of TLR3 during hyperoxia-induced acute lung injury.
CT Ranjith-Kumar; Karen E Duffy; J L Jordan; A Eaton-Bassiri; Robert Vaughan; Scott A Hoose; Roberta J Lamb; Robert T Sarisky; C Cheng Kao
Single-stranded oligonucleotides can inhibit cytokine production induced by human toll-like receptor 3.

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All Publications

2009: Reginald Clayton; Asa Ohagen; Francois Nicol; Alfred M Del Vecchio; Tim H M Jonckers; Olivia Goethals; Marnix Van Loock; Lieve Michiels; John Grigsby; Zheng Xu; Yuan Peng Zhang; Lester L Gutshall; Mark Cunningham; Haiyan Jiang; Sharon Bola; Robert T Sarisky; Kurt Hertogs
Sustained and specific in vitro inhibition of HIV-1 replication by a protease inhibitor encapsulated in gp120-targeted liposomes.
Antiviral research 2009;84(2):142-9.
2008: Lynne Murray; Darryl A Knight; Laura McAlonan; Rochelle Argentieri; Amrita Joshi; Furquan Shaheen; Mark Cunningham; Lena Alexopolou; Richard A Flavell; Robert T Sarisky; Cory M Hogaboam
Deleterious role of TLR3 during hyperoxia-induced acute lung injury.
American journal of respiratory and critical care medicine 2008;178(12):1227-37.
2008: CT Ranjith-Kumar; Karen E Duffy; J L Jordan; A Eaton-Bassiri; Robert Vaughan; Scott A Hoose; Roberta J Lamb; Robert T Sarisky; C Cheng Kao
Single-stranded oligonucleotides can inhibit cytokine production induced by human toll-like receptor 3.
Molecular and cellular biology 2008;28(14):4507-19.
2007: Karen E Duffy; Roberta J Lamb; Lani R San Mateo; Jarrat L Jordan; Gabriela Canziani; Michael Brigham-Burke; Jeremy Korteweg; Mark Cunningham; Heena Solanki Beck; Jill Carton; Jill Giles-Komar; Cynthia Duchala; Robert T Sarisky; Lamine Mbow
Down modulation of human TLR3 function by a monoclonal antibody.
Cellular immunology 2007;248(2):103-14.
2007: Roberta J Lamb; Renold J Capocasale; Karen E Duffy; Robert T Sarisky; Lamine Mbow
Identification and characterization of novel bone marrow myeloid DEC205+Gr-1+ cell subsets that differentially express chemokine and TLRs.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7833-9.
2007: CT Ranjith-Kumar; William Miller; Jingchuan Sun; Jin Xiong; Jon Santos; Ian Yarbrough; Roberta J Lamb; Juliane Mills; Karen E Duffy; Scott Hoose; Mark Cunningham; Andreas Holzenburg; Lamine Mbow; Robert T Sarisky; C Cheng Kao
Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells.
The Journal of biological chemistry 2007;282(24):17696-705.
2007: George Burton; Thomas W Ku; Thomas J Carr; Terry Kiesow; Robert T Sarisky; Juili Lin-Goerke; Glenn Hofmann; Martin J Slater; David Haigh; Dashyant Dhanak; Victor K Johnson; Nigel R Parry; Pia Thommes
Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity.
Bioorganic & medicinal chemistry letters 2007;17(7):1930-3.
2007: CT Ranjith-Kumar; William Miller; Jin Xiong; William K Russell; Roberta Lamb; Jon Santos; Karen E Duffy; Larissa Cleveland; Mary Park; Kanchan Bhardwaj; Zhaoxiang Wu; David H Russell; Robert T Sarisky; Lamine Mbow; C Cheng Kao
Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain.
The Journal of biological chemistry 2007;282(10):7668-78.
2007: Adriana Weinberg; Jeffry J Leary; Robert T Sarisky; Myron J Levin
Factors that affect in vitro measurement of the susceptibility of herpes simplex virus to nucleoside analogues.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2007;38(2):139-45.
2007: Changbao Liu; Nicole D Day; Patrick J Branigan; Lester L Gutshall; Robert T Sarisky; Alfred M Del Vecchio
Relationship between the loss of neutralizing antibody binding and fusion activity of the F protein of human respiratory syncytial virus.
Virology journal 2007;4():71.
2007: Reginald Clayton; Asa Ohagen; Olivia Goethals; Alexandra Smets; Marnix Van Loock; Lieve Michiels; Erin Kennedy-Johnston; Mark Cunningham; Haiyan Jiang; Sharon Bola; Lester Gutshall; George Gunn; Alfred Del Vecchio; Robert T Sarisky; Sabine Hallenberger; Kurt Hertogs
Binding kinetics, uptake and intracellular accumulation of F105, an anti-gp120 human IgG1kappa monoclonal antibody, in HIV-1 infected cells.
Journal of virological methods 2007;139(1):17-23.
2006: Alfred M Del Vecchio; Robert T Sarisky
Small molecule and biologic inhibitors of hepatitis C virus: a symbiotic approach.
Mini reviews in medicinal chemistry 2006;6(11):1263-8.
2006: William G Glass; Robert T Sarisky; Alfred M Del Vecchio
Not-so-sweet sixteen: the role of IL-16 in infectious and immune-mediated inflammatory diseases.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2006;26(8):511-20.
2006: C Chris Huang; Karen E Duffy; Lani R San Mateo; Bernard Y Amegadzie; Robert T Sarisky; Lamine Mbow
A pathway analysis of poly(I:C)-induced global gene expression change in human peripheral blood mononuclear cells.
Physiological genomics 2006;26(2):125-33.
2006: Alfred M Del Vecchio; Robert T Sarisky
Cold virus fusion or stopping fusion cold--inhibitors of the human respiratory syncytial virus F protein.
Recent patents on anti-infective drug discovery 2006;1(2):247-54.
2006: Lamine Mbow; Ashlyn Eaton-Bassiri; W G Glass; Alfred M Del Vecchio; Robert T Sarisky
Small molecule and biologic modulators of the immune response to hepatitis C virus.
Mini reviews in medicinal chemistry 2006;6(5):527-31.
2006: Jingchuan Sun; Karen E Duffy; CT Ranjith-Kumar; Jin Xiong; Roberta J Lamb; Jon Santos; Hema Masarapu; Mark Cunningham; Andreas Holzenburg; Robert T Sarisky; Lamine Mbow; Cheng Kao
Structural and functional analyses of the human Toll-like receptor 3. Role of glycosylation.
The Journal of biological chemistry 2006;281(16):11144-51.
2006: Karen A Evans; Deping Chai; Todd L Graybill; George Burton; Robert T Sarisky; Juili Lin-Goerke; Victor K Johnston; Ralph A Rivero
An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
Bioorganic & medicinal chemistry letters 2006;16(8):2205-8.
2006: Rosanna Tedesco; Antony N Shaw; Ramesh Bambal; Deping Chai; Nestor O Concha; Michael G Darcy; Dashyant Dhanak; Duke M Fitch; Adam T Gates; Warren G Gerhardt; Dina L Halegoua; Chao Han; Glenn Hofmann; Victor K Johnston; Arun C Kaura; Nannan Liu; Richard M Keenan; Juili Lin-Goerke; Robert T Sarisky; Kenneth J Wiggall; Michael N Zimmerman; Kevin J Duffy
3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
Journal of medicinal chemistry 2006;49(3):971-83.
2006: Patrick J Branigan; Nicole D Day; Changbao Liu; Lester L Gutshall; José A Melero; Robert T Sarisky; Alfred M Del Vecchio
The cytoplasmic domain of the F protein of Human respiratory syncytial virus is not required for cell fusion.
The Journal of general virology 2006;87(Pt 2):395-8.
2006: Nicole D Day; Patrick J Branigan; Changbao Liu; Lester L Gutshall; Jianquan Luo; José A Melero; Robert T Sarisky; Alfred M Del Vecchio
Contribution of cysteine residues in the extracellular domain of the F protein of human respiratory syncytial virus to its function.
Virology journal 2006;3():34.
2005: Fred Del Vecchio; Lamine Mbow; Robert T Sarisky
Novel treatment options for infectious exacerbations.
Drug discovery today 2005;10(22):1500-2.
2005: Lamine Mbow; Robert T Sarisky
Modulating toll-like receptor signalling as a novel antiinfective approach.
Drug news & perspectives 2005;18(3):179-84.
2005: George Burton; Thomas W Ku; Thomas J Carr; Terry Kiesow; Robert T Sarisky; Juili Lin-Goerke; Audrey Baker; David L Earnshaw; Glenn Hofmann; Richard M Keenan; Dashyant Dhanak
Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture.
Bioorganic & medicinal chemistry letters 2005;15(6):1553-6.
2005: Patrick J Branigan; Changbao Liu; Nicole D Day; Lester L Gutshall; Robert T Sarisky; Alfred M Del Vecchio
Use of a novel cell-based fusion reporter assay to explore the host range of human respiratory syncytial virus F protein.
Virology journal 2005;2():54.
2004: Lamine Mbow; Robert T Sarisky
Exploiting toll-like receptors for designed multiple ligands.
Drug discovery today 2004;9(24):1038-9.
2004: Ashlyn Eaton-Bassiri; Susan B Dillon; Mark Cunningham; Michael A Rycyzyn; Juliane Mills; Robert T Sarisky; Lamine Mbow
Toll-like receptor 9 can be expressed at the cell surface of distinct populations of tonsils and human peripheral blood mononuclear cells.
Infection and immunity 2004;72(12):7202-11.
2004: CT Ranjith-Kumar; Robert T Sarisky; Lester L Gutshall; M Thomson; C Cheng Kao
De novo initiation pocket mutations have multiple effects on hepatitis C virus RNA-dependent RNA polymerase activities.
Journal of virology 2004;78(22):12207-17.
2004: Emil Chuang; Alfred Del Vecchio; Steve Smolinski; Xiao-Yu Song; Robert T Sarisky
Biomedicines to reduce inflammation but not viral load in chronic HCV--what's the sense?
Trends in biotechnology 2004;22(10):517-23.
2004: Lamine Mbow; Robert T Sarisky
What is disrupting IFN-alpha's antiviral activity?
Trends in biotechnology 2004;22(8):395-9.
2004: Robert T Sarisky
Non-nucleoside inhibitors of the HCV polymerase.
The Journal of antimicrobial chemotherapy 2004;54(1):14-6.
2004: Adam T Gates; Robert T Sarisky; Baohua Gu
Sequence requirements for the development of a chimeric HCV replicon system.
Virus research 2004;100(2):213-22.
2004: Baohua Gu; Lester L Gutshall; Derrick Maley; Cynthia M Pruss; Tammy T Nguyen; Carol Silverman; Juili Lin-Goerke; Sanjay S Khandekar; Changbao Liu; Audrey E Baker; David J Casper; Robert T Sarisky
Mapping cooperative activity of the hepatitis C virus RNA-dependent RNA polymerase using genotype 1a-1b chimeras.
Biochemical and biophysical research communications 2004;313(2):343-50.
2003: Victor K Johnston; Derrick Maley; Robert C Gagnon; Claus W Grassmann; Sven-Erik Behrens; Robert T Sarisky
Kinetic profile of a heterocyclic HCV replicon RNA synthesis inhibitor.
Biochemical and biophysical research communications 2003;311(3):672-7.
2003: Olaf Isken; Claus W Grassmann; Robert T Sarisky; Michael Kann; Suisheng Zhang; Frank Grosse; Peter N Kao; Sven-Erik Behrens
Members of the NF90/NFAR protein group are involved in the life cycle of a positive-strand RNA virus.
The EMBO journal 2003;22(21):5655-65.
2003: Tammy T Nguyen; Adam T Gates; Lester L Gutshall; Victor K Johnston; Baohua Gu; Kevin J Duffy; Robert T Sarisky
Resistance profile of a hepatitis C virus RNA-dependent RNA polymerase benzothiadiazine inhibitor.
Antimicrobial agents and chemotherapy 2003;47(11):3525-30.
2003: Douglas J DeMarini; Victor K Johnston; Madhavi Konduri; Lester L Gutshall; Robert T Sarisky
Intracellular hepatitis C virus RNA-dependent RNA polymerase activity.
Journal of virological methods 2003;113(1):65-8.
2003: Robert T Sarisky; Teresa H Bacon; Ron J Boon; Karen E Duffy; K M Esser; J Leary; Leslie A Locke; Tammy T Nguyen; Matthew R Quail; Robin Saltzman
Profiling penciclovir susceptibility and prevalence of resistance of herpes simplex virus isolates across eleven clinical trials.
Archives of virology 2003;148(9):1757-69.
2003: CT Ranjith-Kumar; Jan Lee Santos; Lester L Gutshall; Victor K Johnston; Juili Lin-Goerke; Min-Ju Kim; David J Porter; Derrick Maley; Cathy Greenwood; David L Earnshaw; Audrey Baker; Baohua Gu; Carol Silverman; Robert T Sarisky; Cheng Kao
Enzymatic activities of the GB virus-B RNA-dependent RNA polymerase.
Virology 2003;312(2):270-80.
2003: CT Ranjith-Kumar; Lester L Gutshall; Robert T Sarisky; C Cheng Kao
Multiple interactions within the hepatitis C virus RNA polymerase repress primer-dependent RNA synthesis.
Journal of molecular biology 2003;330(4):675-85.
2003: Baohua Gu; Victor K Johnston; Lester L Gutshall; Tammy T Nguyen; Richard R Gontarek; Michael G Darcy; Rosanna Tedesco; Dashyant Dhanak; Kevin J Duffy; C Cheng Kao; Robert T Sarisky
Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives.
The Journal of biological chemistry 2003;278(19):16602-7.
2003: Baohua Gu; Adam T Gates; Olaf Isken; Sven-Erik Behrens; Robert T Sarisky
Replication studies using genotype 1a subgenomic hepatitis C virus replicons.
Journal of virology 2003;77(9):5352-9.
2003: Teresa H Bacon; Myron J Levin; Jeffry J Leary; Robert T Sarisky; David Sutton
Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapy.
Clinical microbiology reviews 2003;16(1):114-28.
2002: CT Ranjith-Kumar; Lester L Gutshall; Min-Ju Kim; Robert T Sarisky; C Cheng Kao
Requirements for de novo initiation of RNA synthesis by recombinant flaviviral RNA-dependent RNA polymerases.
Journal of virology 2002;76(24):12526-36.
2002: CT Ranjith-Kumar; Young-Chan Kim; Lester L Gutshall; Carol Silverman; Sanjay S Khandekar; Robert T Sarisky; C Cheng Kao
Mechanism of de novo initiation by the hepatitis C virus RNA-dependent RNA polymerase: role of divalent metals.
Journal of virology 2002;76(24):12513-25.
2002: Dashyant Dhanak; Kevin J Duffy; Victor K Johnston; Juili Lin-Goerke; Michael G Darcy; Antony N Shaw; Baohua Gu; Carol Silverman; Adam T Gates; Michael Nonnemacher; David L Earnshaw; David J Casper; Arun C Kaura; Audrey Baker; Cathy Greenwood; Lester L Gutshall; Derrick Maley; Alfred DelVecchio; Ricardo Macarron; Glenn Hofmann; Zaid Alnoah; Hung-Yuan Cheng; George Chan; Sanjay S Khandekar; Richard M Keenan; Robert T Sarisky
Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
The Journal of biological chemistry 2002;277(41):38322-7.
2002: Robert T Sarisky; Teresa H Bacon; Ron J Boon; Leslie A Locke; Tammy T Nguyen; Jeffry Leary; Klaus Esser; Robin Saltzman
Penciclovir susceptibilities of herpes simplex virus isolates from patients using penciclovir cream for treatment of recurrent herpes labialis.
Antimicrobial agents and chemotherapy 2002;46(9):2848-53.
2002: Karen E Duffy; Matthew R Quail; Tammy T Nguyen; Robert J Wittrock; Joan O Bartus; Wendy M Halsey; Jeffry J Leary; Teresa H Bacon; Robert T Sarisky
Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations.
BMC infectious diseases 2002;2():7.
2002: Jeffry J Leary; Robert J Wittrock; Robert T Sarisky; Adriana Weinberg; Myron J Levin
Susceptibilities of herpes simplex viruses to penciclovir and acyclovir in eight cell lines.
Antimicrobial agents and chemotherapy 2002;46(3):762-8.
2002: Robert T Sarisky; Paul Crosson; Rachel Cano; Matthew R Quail; Tammy T Nguyen; Robert J Wittrock; Teresa H Bacon; Stephen L Sacks; Laure Caspers-Velu; Richard L Hodinka; Jeffry J Leary
Comparison of methods for identifying resistant herpes simplex virus and measuring antiviral susceptibility.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2002;23(3):191-200.
2001: Robert T Sarisky; R Cano; Tammy T Nguyen; Robert J Wittrock; Karen E Duffy; P Clark; J O Bartus; Teresa H Bacon; Laure Caspers-Velu; Richard L Hodinka; Jeffry J Leary
Biochemical characterization of a virus isolate, recovered from a patient with herpes keratitis, that was clinically resistant to acyclovir.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2001;33(12):2034-9.
2001: Myron J Levin; Adriana Weinberg; Jeffry J Leary; Robert T Sarisky
Development of acyclovir-resistant herpes simplex virus early during the treatment of herpes neonatorum.
The Pediatric infectious disease journal 2001;20(11):1094-7.
2001: CT Ranjith-Kumar; J Gajewski; Lester L Gutshall; Derrick Maley; Robert T Sarisky; C Cheng Kao
Terminal nucleotidyl transferase activity of recombinant Flaviviridae RNA-dependent RNA polymerases: implication for viral RNA synthesis.
Journal of virology 2001;75(18):8615-23.
2001: Robert T Sarisky; Matthew R Quail; P E Clark; Tammy T Nguyen; WS Halsey; Robert J Wittrock; J O'Leary Bartus; M M Van Horn; Ganesh Sathe; S Van Horn; M D Kelly; Teresa H Bacon; Jeffry J Leary
Characterization of herpes simplex viruses selected in culture for resistance to penciclovir or acyclovir.
Journal of virology 2001;75(4):1761-9.
2001: Robert T Sarisky; H R Bartus; S A Dennis; Matthew R Quail; Tammy T Nguyen; Robert J Wittrock; WS Halsey; Teresa H Bacon; Jeffry J Leary; David Sutton
Absence of rapid selection for acyclovir or penciclovir resistance following suboptimal oral prodrug therapy of HSV-infected mice.
BMC infectious diseases 2001;1():24.
2000: Robert T Sarisky; Tammy T Nguyen; Karen E Duffy; Robert J Wittrock; Jeffry J Leary
Difference in incidence of spontaneous mutations between Herpes simplex virus types 1 and 2.
Antimicrobial agents and chemotherapy 2000;44(6):1524-9.