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Stefania Sarno

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Chemicals & Drugs

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Francesca Vallese; Paola Berto; Laura Cendron; Edith De Rosa; Giorgio Mario Giacometti; Maria Ruzzene; Stefania Sarno; Paola Costantini
Biochemical analysis of the interactions between the proteins involved in the [FeFe]-hydrogenase maturation process.
Graziano Lolli; Marco Mazzorana; Flavio Meggio; Roberto Battistutta; Luca Cesaro; Giorgio Cozza; Arianna Donella-Deana; Cinzia Franchin; Stefania Sarno; Elena Tibaldi; Andrea Venerando; Lorenzo A Pinna
Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight.
Mauro Salvi; Stefania Sarno; Edlir Trashi; Oriano Marin; Alessandro Negro; Lorenzo A Pinna
Superiority of PLK-2 as α-synuclein phosphorylating agent relies on unique specificity determinants.

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2012: Francesca Vallese; Paola Berto; Laura Cendron; Edith De Rosa; Giorgio Mario Giacometti; Maria Ruzzene; Stefania Sarno; Paola Costantini
Biochemical analysis of the interactions between the proteins involved in the [FeFe]-hydrogenase maturation process.
The Journal of biological chemistry 2012;287(43):36544-55.
2012: Graziano Lolli; Marco Mazzorana; Flavio Meggio; Roberto Battistutta; Luca Cesaro; Giorgio Cozza; Arianna Donella-Deana; Cinzia Franchin; Stefania Sarno; Elena Tibaldi; Andrea Venerando; Lorenzo A Pinna
Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight.
Biochemistry 2012;51(31):6097-107.
2012: Mauro Salvi; Stefania Sarno; Edlir Trashi; Oriano Marin; Alessandro Negro; Lorenzo A Pinna
Superiority of PLK-2 as α-synuclein phosphorylating agent relies on unique specificity determinants.
Biochemical and biophysical research communications 2012;418(1):156-60.
2011: Roberto Battistutta; Giorgio Cozza; Mustapha Haddach; Graziano Lolli; Flavio Meggio; Sean E O'Brien; Elena Papinutto; Fabrice Pierre; David M Ryckman; Stefania Sarno; Adam Siddiqui-Jain; Kenna Anderes; Lorenzo A Pinna
Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer.
Biochemistry 2011;50(39):8478-88.
2011: Kendra Tosoni; Michela Zottini; Stefania Sarno; Francesca Sparla; Alex Costa; Stefano D'Alessandro; Lorenzo A Pinna; Maria Ruzzene
The p23 co-chaperone protein is a novel substrate of CK2 in Arabidopsis.
Molecular and cellular biochemistry 2011;356(1-2):245-54.
2011: Stefania Sarno; Elena Papinutto; C Franchin; Jenny Bain; Martin Elliott; Flavio Meggio; Zygmunt Kazimierczuk; A Orzeszko; Giuseppe Zanotti; Roberto Battistutta; Lorenzo A Pinna
ATP site-directed inhibitors of protein kinase CK2: an update.
Current topics in medicinal chemistry 2011;11(11):1340-51.
2010: Andrea Venerando; Oriano Marin; Giorgio Cozza; Victor H Bustos; Stefania Sarno; Lorenzo Alberto Pinna
Isoform specific phosphorylation of p53 by protein kinase CK1.
Cellular and molecular life sciences : CMLS 2010;67(7):1105-18.
2010: Mario Angelo Pagano; Oriano Marin; Giorgio Cozza; Stefania Sarno; Flavio Meggio; Kate J Treharne; Anil Mehta; Lorenzo A Pinna
Cystic fibrosis transmembrane regulator fragments with the Phe508 deletion exert a dual allosteric control over the master kinase CK2.
The Biochemical journal 2010;426(1):19-29.
2009: Mauro Salvi; Dong Xu; Yingyu Chen; Anna Cabrelle; Stefania Sarno; Lorenzo A Pinna
Programmed cell death protein 5 (PDCD5) is phosphorylated by CK2 in vitro and in 293T cells.
Biochemical and biophysical research communications 2009;387(3):606-10.
2009: Giorgio Cozza; Marco Mazzorana; Elena Papinutto; Jenny Bain; Matthew Elliott; Giovanni Di Maira; Alessandra Gianoncelli; Mario Angelo Pagano; Stefania Sarno; Maria Ruzzene; Roberto Battistutta; Flavio Meggio; Stefano Moro; Giuseppe Zagotto; Lorenzo A Pinna
Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2.
The Biochemical journal 2009;421(3):387-95.
2009: Mauro Salvi; Stefania Sarno; Luca Cesaro; Hideji Nakamura; Lorenzo A Pinna
Extraordinary pleiotropy of protein kinase CK2 revealed by weblogo phosphoproteome analysis.
Biochimica et biophysica acta 2009;1793(5):847-59.
2008: Mario Angelo Pagano; Jenny Bain; Zygmunt Kazimierczuk; Stefania Sarno; Maria Ruzzene; Giovanni Di Maira; Matthew Elliott; Andrzej Orzeszko; Giorgio Cozza; Flavio Meggio; Lorenzo A Pinna
The selectivity of inhibitors of protein kinase CK2: an update.
The Biochemical journal 2008;415(3):353-65.
2008: Stefania Sarno; Lorenzo A Pinna
Protein kinase CK2 as a druggable target.
Molecular bioSystems 2008;4(9):889-94.
2008: Giorgia Poletto; Jordi Vilardell; Oriano Marin; Mario Angelo Pagano; Giorgio Cozza; Stefania Sarno; Antoni Falqués; Emilio Itarte; Lorenzo A Pinna; Flavio Meggio
The regulatory beta subunit of protein kinase CK2 contributes to the recognition of the substrate consensus sequence. A study with an eIF2 beta-derived peptide.
Biochemistry 2008;47(32):8317-25.
2008: Mario Angelo Pagano; Giorgio Arrigoni; Oriano Marin; Stefania Sarno; Flavio Meggio; Kate J Treharne; Anil Mehta; Lorenzo A Pinna
Modulation of protein kinase CK2 activity by fragments of CFTR encompassing F508 may reflect functional links with cystic fibrosis pathogenesis.
Biochemistry 2008;47(30):7925-36.
2008: Giorgio Arrigoni; Mario Angelo Pagano; Stefania Sarno; Luca Cesaro; P James; Lorenzo A Pinna
Mass spectrometry analysis of a protein kinase CK2beta subunit interactome isolated from mouse brain by affinity chromatography.
Journal of proteome research 2008;7(3):990-1000.
2007: Roberto Battistutta; Marco Mazzorana; Laura Cendron; Andrea Bortolato; Stefania Sarno; Zygmunt Kazimierczuk; Giuseppe Zanotti; Stefano Moro; Lorenzo A Pinna
The ATP-binding site of protein kinase CK2 holds a positive electrostatic area and conserved water molecules.
Chembiochem : a European journal of chemical biology 2007;8(15):1804-9.
2007: Mario Angelo Pagano; Giorgia Poletto; Giovanni Di Maira; Giorgio Cozza; Maria Ruzzene; Stefania Sarno; Jenny Bain; Matthew Elliott; Stefano Moro; Giuseppe Zagotto; Flavio Meggio; Lorenzo A Pinna
Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors.
Chembiochem : a European journal of chemical biology 2007;8(1):129-39.
2006: Mauro Salvi; Stefania Sarno; Oriano Marin; Flavio Meggio; Emilio Itarte; Lorenzo A Pinna
Discrimination between the activity of protein kinase CK2 holoenzyme and its catalytic subunits.
FEBS letters 2006;580(16):3948-52.
2006: Giorgio Cozza; Paolo Bonvini; Elisa Zorzi; Giorgia Poletto; Mario Angelo Pagano; Stefania Sarno; Arianna Donella-Deana; Giuseppe Zagotto; Angelo Rosolen; Lorenzo A Pinna; Flavio Meggio; Stefano Moro
Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
Journal of medicinal chemistry 2006;49(8):2363-6.
2005: Stefania Sarno; Mauro Salvi; Roberto Battistutta; Giuseppe Zanotti; Lorenzo A Pinna
Features and potentials of ATP-site directed CK2 inhibitors.
Biochimica et biophysica acta 2005;1754(1-2):263-70.
2005: Roberto Battistutta; Marco Mazzorana; Stefania Sarno; Zygmunt Kazimierczuk; Giuseppe Zanotti; Lorenzo A Pinna
Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.
Chemistry & biology 2005;12(11):1211-9.
2005: Stefania Sarno; Maria Ruzzene; Pietrogiulio Frascella; Mario Angelo Pagano; Flavio Meggio; Alfonso Zambon; Marco Mazzorana; Giovanni Di Maira; Vittorio Lucchini; Lorenzo A Pinna
Development and exploitation of CK2 inhibitors.
Molecular and cellular biochemistry 2005;274(1-2):69-76.
2005: Franc Llorens; Stefania Sarno; Eduard Sarró; Anna Duarri; Nerea Roher; Flavio Meggio; Maria Plana; Lorenzo A Pinna; Emilio Itarte
Cross talk between protein kinase CK2 and eukaryotic translation initiation factor eIF2beta subunit.
Molecular and cellular biochemistry 2005;274(1-2):53-61.
2005: Mario Angelo Pagano; Stefania Sarno; Giorgia Poletto; Giorgio Cozza; Lorenzo A Pinna; Flavio Meggio
Autophosphorylation at the regulatory beta subunit reflects the supramolecular organization of protein kinase CK2.
Molecular and cellular biochemistry 2005;274(1-2):23-9.
2005: Giovanni Di Maira; Mauro Salvi; Giorgio Arrigoni; Oriano Marin; Stefania Sarno; F Brustolon; Lorenzo A Pinna; Maria Ruzzene
Protein kinase CK2 phosphorylates and upregulates Akt/PKB.
Cell death and differentiation 2005;12(6):668-77.
2005: Matteo Barberis; Luca De Gioia; Maria Ruzzene; Stefania Sarno; Paola Coccetti; Piercarlo Fantucci; Marco Vanoni; Lilia Alberghina
The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain.
The Biochemical journal 2005;387(Pt 3):639-47.
2004: Mario Angelo Pagano; Mariola Andrzejewska; Maria Ruzzene; Stefania Sarno; Luca Cesaro; Jenny Bain; Matthew Elliott; Flavio Meggio; Zygmunt Kazimierczuk; Lorenzo A Pinna
Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.
Journal of medicinal chemistry 2004;47(25):6239-47.
2004: Flavio Meggio; Mario Angelo Pagano; Stefano Moro; Giuseppe Zagotto; Maria Ruzzene; Stefania Sarno; Giorgio Cozza; Jenny Bain; Matthew Elliott; Arianna Donella Deana; Anna Maria Brunati; Lorenzo A Pinna
Inhibition of protein kinase CK2 by condensed polyphenolic derivatives. An in vitro and in vivo study.
Biochemistry 2004;43(40):12931-6.
2004: Joanna I Loizou; Sherif F El-Khamisy; Anastasia Zlatanou; David Moore; Douglas W Chan; Jun Qin; Stefania Sarno; Flavio Meggio; Lorenzo A Pinna; Keith W Caldecott
The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks.
Cell 2004;117(1):17-28.
2003: Franc Llorens; Nerea Roher; Francesc Miro; Stefania Sarno; F Xavier Ruiz; Flavio Meggio; Maria Plana; Lorenzo A Pinna; Emilio Itarte
Eukaryotic translation-initiation factor eIF2beta binds to protein kinase CK2: effects on CK2alpha activity.
The Biochemical journal 2003;375(Pt 3):623-31.
2003: Stefania Sarno; Erika De Moliner; Maria Ruzzene; Mario Angelo Pagano; Roberto Battistutta; Jenny Bain; Doriano Fabbro; Joseph Schoepfer; Matthew Elliott; Pascal Furet; Flavio Meggio; Giuseppe Zanotti; Lorenzo A Pinna
Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA).
The Biochemical journal 2003;374(Pt 3):639-46.
2003: Arianna Donella-Deana; Luca Cesaro; Stefania Sarno; Maria Ruzzene; Anna Maria Brunati; Oriano Marin; Greg Vilk; Amanda Doherty-Kirby; Gilles Lajoie; David W Litchfield; Lorenzo A Pinna
Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity.
The Biochemical journal 2003;372(Pt 3):841-9.
2003: Erika De Moliner; Stefano Moro; Stefania Sarno; Giuseppe Zagotto; Giuseppe Zanotti; Lorenzo A Pinna; Roberto Battistutta
Inhibition of protein kinase CK2 by anthraquinone-related compounds. A structural insight.
The Journal of biological chemistry 2003;278(3):1831-6.
2002: Sonia Facchin; Stefania Sarno; Oriano Marin; Raffaele Lopreiato; Geppo Sartori; Lorenzo A Pinna
Acidophilic character of yeast PID261/BUD32, a putative ancestor of eukaryotic protein kinases.
Biochemical and biophysical research communications 2002;296(5):1366-71.
2002: Stefania Sarno; Paola Ghisellini; Lorenzo A Pinna
Unique activation mechanism of protein kinase CK2. The N-terminal segment is essential for constitutive activity of the catalytic subunit but not of the holoenzyme.
The Journal of biological chemistry 2002;277(25):22509-14.
2002: Stefania Sarno; Stefano Moro; Flavio Meggio; Giuseppe Zagotto; Diego Dal Ben; Paola Ghisellini; Roberto Battistutta; Giuseppe Zanotti; Lorenzo A Pinna
Toward the rational design of protein kinase casein kinase-2 inhibitors.
Pharmacology & therapeutics 2002;93(2-3):159-68.
2001: Flavio Meggio; Oriano Marin; Marco Boschetti; Stefania Sarno; Lorenzo A Pinna
HIV-1 Rev transactivator: a beta-subunit directed substrate and effector of protein kinase CK2.
Molecular and cellular biochemistry 2001;227(1-2):145-51.
2001: Stefania Sarno; Paola Ghisellini; Luca Cesaro; Roberto Battistutta; Lorenzo A Pinna
Generation of mutants of CK2alpha which are dependent on the beta-subunit for catalytic activity.
Molecular and cellular biochemistry 2001;227(1-2):13-9.
2001: Roberto Battistutta; Erika De Moliner; Stefania Sarno; Giuseppe Zanotti; Lorenzo A Pinna
Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole.
Protein science : a publication of the Protein Society 2001;10(11):2200-6.
2001: Nerea Roher; Stefania Sarno; Francesc Miro; Maria Ruzzene; Franc Llorens; Flavio Meggio; Emilio Itarte; Lorenzo A Pinna; Maria Plana
The carboxy-terminal domain of Grp94 binds to protein kinase CK2 alpha but not to CK2 holoenzyme.
FEBS letters 2001;505(1):42-6.
2001: Arianna Donella-Deana; Luca Cesaro; Stefania Sarno; Anna Maria Brunati; Maria Ruzzene; Lorenzo A Pinna
Autocatalytic tyrosine-phosphorylation of protein kinase CK2 alpha and alpha' subunits: implication of Tyr182.
The Biochemical journal 2001;357(Pt 2):563-7.
2001: Stefania Sarno; H Reddy; Flavio Meggio; Maria Ruzzene; SP Davies; Arianna Donella-Deana; D Shugar; Lorenzo A Pinna
Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').
FEBS letters 2001;496(1):44-8.
2000: Flavio Meggio; Alessandro Negro; Stefania Sarno; Maria Ruzzene; Alessandro Bertoli; Maria Catia Sorgato; Lorenzo A Pinna
Bovine prion protein as a modulator of protein kinase CK2.
The Biochemical journal 2000;352 Pt 1():191-6.
2000: Stefania Sarno; Oriano Marin; Marco Boschetti; Mario Angelo Pagano; Flavio Meggio; Lorenzo A Pinna
Cooperative modulation of protein kinase CK2 by separate domains of its regulatory beta-subunit.
Biochemistry 2000;39(40):12324-9.
2000: Roberto Battistutta; Stefania Sarno; Erika De Moliner; Elena Papinutto; Giuseppe Zanotti; Lorenzo A Pinna
The replacement of ATP by the competitive inhibitor emodin induces conformational modifications in the catalytic site of protein kinase CK2.
The Journal of biological chemistry 2000;275(38):29618-22.
2000: Oriano Marin; Stefania Sarno; Marco Boschetti; Mario Angelo Pagano; Flavio Meggio; Vincenzo Ciminale; Donna M D'Agostino; Lorenzo A Pinna
Unique features of HIV-1 Rev protein phosphorylation by protein kinase CK2 ('casein kinase-2').
FEBS letters 2000;481(1):63-7.
2000: Roberto Battistutta; Stefania Sarno; Erika De Moliner; Oriano Marin; Olaf-Georg Issinger; Giuseppe Zanotti; Lorenzo A Pinna
The crystal structure of the complex of Zea mays alpha subunit with a fragment of human beta subunit provides the clue to the architecture of protein kinase CK2 holoenzyme.
European journal of biochemistry / FEBS 2000;267(16):5184-90.
2000: Maria Ruzzene; Anna Maria Brunati; Stefania Sarno; Oriano Marin; Arianna Donella-Deana; Lorenzo A Pinna
Ser/Thr phosphorylation of hematopoietic specific protein 1 (HS1): implication of protein kinase CK2.
European journal of biochemistry / FEBS 2000;267(10):3065-72.
2000: Flavio Meggio; Maria Ruzzene; Stefania Sarno; Mario Angelo Pagano; Lorenzo A Pinna
pCMB treatment reveals the essential role of cysteinyl residues in conferring functional competence to the regulatory subunit of protein kinase CK2.
Biochemical and biophysical research communications 2000;267(1):427-32.
1999: Maria Ruzzene; Anna Maria Brunati; Stefania Sarno; Arianna Donella-Deana; Lorenzo A Pinna
Hematopoietic lineage cell specific protein 1 associates with and down-regulates protein kinase CK2.
FEBS letters 1999;461(1-2):32-6.
1999: Oriano Marin; Flavio Meggio; Stefania Sarno; Luca Cesaro; Mario Angelo Pagano; Lorenzo A Pinna
Tyrosine versus serine/threonine phosphorylation by protein kinase casein kinase-2. A study with peptide substrates derived from immunophilin Fpr3.
The Journal of biological chemistry 1999;274(41):29260-5.
1999: Barbara Guerra; Brigitte Boldyreff; Stefania Sarno; Luca Cesaro; Olaf-Georg Issinger; Lorenzo A Pinna
CK2: a protein kinase in need of control.
Pharmacology & therapeutics 1999;82(2-3):303-13.
1999: Flavio Meggio; Oriano Marin; Stefania Sarno; Lorenzo A Pinna
Functional analysis of CK2beta-derived synthetic fragments.
Molecular and cellular biochemistry 1999;191(1-2):35-42.
1999: Stefania Sarno; P Vaglio; Luca Cesaro; Oriano Marin; Lorenzo A Pinna
A multifunctional network of basic residues confers unique properties to protein kinase CK2.
Molecular and cellular biochemistry 1999;191(1-2):13-9.
1998: Stefania Sarno; Oriano Marin; Paola Ghisellini; Flavio Meggio; Lorenzo A Pinna
Biochemical evidence that the N-terminal segments of the alpha subunit and the beta subunit play interchangeable roles in the activation of protein kinase CK2.
FEBS letters 1998;441(1):29-33.
1997: Stefania Sarno; P Vaglio; Oriano Marin; Olaf-Georg Issinger; K Ruffato; Lorenzo A Pinna
Mutational analysis of residues implicated in the interaction between protein kinase CK2 and peptide substrates.
Biochemistry 1997;36(39):11717-24.
1997: Stefania Sarno; P Vaglio; Oriano Marin; Flavio Meggio; Olaf-Georg Issinger; Lorenzo A Pinna
Basic residues in the 74-83 and 191-198 segments of protein kinase CK2 catalytic subunit are implicated in negative but not in positive regulation by the beta-subunit.
European journal of biochemistry / FEBS 1997;248(2):290-5.
1997: Oriano Marin; Flavio Meggio; Stefania Sarno; Lorenzo A Pinna
Physical dissection of the structural elements responsible for regulatory properties and intersubunit interactions of protein kinase CK2 beta-subunit.
Biochemistry 1997;36(23):7192-8.
1996: Stefania Sarno; P Vaglio; Flavio Meggio; Olaf-Georg Issinger; Lorenzo A Pinna
Protein kinase CK2 mutants defective in substrate recognition. Purification and kinetic analysis.
The Journal of biological chemistry 1996;271(18):10595-601.
1996: Patrizia Agostinis; Arianna Donella-Deana; J Cuveele; AL Vandenbogaerde; Stefania Sarno; Wilfried Merlevede; P de Witte
A comparative analysis of the photosensitized inhibition of growth-factor regulated protein kinases by hypericin-derivatives.
Biochemical and biophysical research communications 1996;220(3):613-7.
1996: P Vaglio; Stefania Sarno; Oriano Marin; Flavio Meggio; Olaf-Georg Issinger; Lorenzo A Pinna
Mapping the residues of protein kinase CK2 alpha subunit responsible for responsiveness to polyanionic inhibitors.
FEBS letters 1996;380(1-2):25-8.
1995: Stefania Sarno; Brigitte Boldyreff; Oriano Marin; B Guerra; Flavio Meggio; Olaf-Georg Issinger; Lorenzo A Pinna
Mapping the residues of protein kinase CK2 implicated in substrate recognition: mutagenesis of conserved basic residues in the alpha-subunit.
Biochemical and biophysical research communications 1995;206(1):171-9.
1994: Oriano Marin; Flavio Meggio; Stefania Sarno; M Andretta; Lorenzo A Pinna
Phosphorylation of synthetic fragments of inhibitor-2 of protein phosphatase-1 by casein kinase-1 and -2. Evidence that phosphorylated residues are not strictly required for efficient targeting by casein kinase-1.
European journal of biochemistry / FEBS 1994;223(2):647-53.
1993: Stefania Sarno; Oriano Marin; Flavio Meggio; Lorenzo A Pinna
Polyamines as negative regulators of casein kinase-2: the phosphorylation of calmodulin triggered by polylysine and by the alpha[66-86] peptide is prevented by spermine.
Biochemical and biophysical research communications 1993;194(1):83-90.
1992: Patrizia Agostinis; Johan Van Lint; Stefania Sarno; P De Witte; Jackie R Vandenheede; Wilfried Merlevede
Rapid stimulation of Ser/Thr protein kinases following treatment of Swiss 3T3 cells with bombesin. Involvement of casein kinase-2 in the signaling pathway of bombesin.
The Journal of biological chemistry 1992;267(14):9732-7.
1992: Patrizia Agostinis; Rita Derua; Stefania Sarno; Jozef Goris; Wilfried Merlevede
Specificity of the polycation-stimulated (type-2A) and ATP,Mg-dependent (type-1) protein phosphatases toward substrates phosphorylated by P34cdc2 kinase.
European journal of biochemistry / FEBS 1992;205(1):241-8.