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Masakiyo Sasahara

Research Profile

Chemicals & Drugs

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TOP 3
G Xu; Y Zheng; J Shen; M Tsuda; T C Dang; Toshihiko Fujimori; M Fukuchi; K Funa; T Hamashima; Yoko Ishii; Masakiyo Sasahara
Functional analysis of platelet-derived growth factor receptor-β in neural stem/progenitor cells.
Tsutomu Wada; Hiroshi Tsuneki; Hiroki Fusanobori; Yoko Ishii; Yukari Kimura; Tetsuro Nakano; Yasuhiro Onogi; Masakiyo Sasahara; Toshiyasu Sasaoka
Cilostazol ameliorates systemic insulin resistance in diabetic db/db mice by suppressing chronic inflammation in adipose tissue via modulation of both adipocyte and macrophage functions.
Tomomi Ichikawa; Shingo Imanishi; Minehiko Inomata; Kenta Kambara; Yukiko Koshimizu; Shoko Matsui; Yuji Matsuya; Toshiro Miwa; Seisuke Okazawa; Masakiyo Sasahara; Kensuke Suzuki; Masaharu Urakaze; Isao Usui; Toru Yamada; Yu Yamazaki; Ryuji Hayashi; Kazuyuki Tobe
Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma.

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All Publications

2013: G Xu; Y Zheng; J Shen; M Tsuda; T C Dang; Toshihiko Fujimori; M Fukuchi; K Funa; T Hamashima; Yoko Ishii; Masakiyo Sasahara
Functional analysis of platelet-derived growth factor receptor-β in neural stem/progenitor cells.
Neuroscience 2013;238():195-208.
2013: Tsutomu Wada; Hiroshi Tsuneki; Hiroki Fusanobori; Yoko Ishii; Yukari Kimura; Tetsuro Nakano; Yasuhiro Onogi; Masakiyo Sasahara; Toshiyasu Sasaoka
Cilostazol ameliorates systemic insulin resistance in diabetic db/db mice by suppressing chronic inflammation in adipose tissue via modulation of both adipocyte and macrophage functions.
European journal of pharmacology 2013;707(1-3):120-9.
2013: Tomomi Ichikawa; Shingo Imanishi; Minehiko Inomata; Kenta Kambara; Yukiko Koshimizu; Shoko Matsui; Yuji Matsuya; Toshiro Miwa; Seisuke Okazawa; Masakiyo Sasahara; Kensuke Suzuki; Masaharu Urakaze; Isao Usui; Toru Yamada; Yu Yamazaki; Ryuji Hayashi; Kazuyuki Tobe
Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma.
Respirology (Carlton, Vic.) 2013;18(2):332-9.
2012: Rika Yonezawa; Kanae Sawakawa; Hiroshi Tsuneki; Tsutomu Wada; Yoko Ishii; Natsumi Matsumoto; Mayuko Morita; Shigeru Saito; Masakiyo Sasahara; Toshiyasu Sasaoka
Central versus peripheral impact of estradiol on the impaired glucose metabolism in ovariectomized mice on a high-fat diet.
American journal of physiology. Endocrinology and metabolism 2012;303(4):E445-56.
2012: Jie Shen; Yusuke Takatsuru; Guihua Xu; Seiji Yamamoto; Thanh Chung Dang; Takeru Hamashima; Yuichi Hattori; Yoko Ishii; Takako Matsushima; Junichi Nabekura; Masakiyo Sasahara
PDGFR-β as a positive regulator of tissue repair in a mouse model of focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2012;32(2):353-67.
2012: Minehiko Inomata; Kenta Kambara; Tatsuhiko Kashii; Shoko Matsui; Toshiro Miwa; Seisuke Okazawa; Ryuji Hayashi; Tomomi Ichikawa; Shingo Imanishi; Kensuke Suzuki; Kazuyuki Tobe; Toru Yamada; Masakiyo Sasahara
Miliary brain metastasis presenting with calcification in a patient with lung cancer: a case report.
Journal of medical case reports 2012;6(1):279.
2012: Taizo Nakagawa; Hiroshi Inoue; Masakiyo Sasahara
Platelet-derived growth factor and renal disease.
Current opinion in nephrology and hypertension 2012;21(1):80-5.
2011: Tatsuya Nogami; Hideyuki Beppu; Takashi Tokoro; Shigeki Moriguchi; Norifumi Shioda; Kohji Fukunaga; Toshihisa Ohtsuka; Yoko Ishii; Masakiyo Sasahara; Yutaka Shimada; Hisao Nishijo; En Li; Isao Kitajima
Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice.
Hippocampus 2011;21(6):678-87.
2011: Phuong Thi Hong Nguyen; Tomoya Nakamura; Etsuro Hori; Susumu Urakawa; Teruko Uwano; Juanjuan Zhao; Ruixi Li; Nguyen Duy Bac; Takeru Hamashima; Yoko Ishii; Takako Matsushima; Taketoshi Ono; Masakiyo Sasahara; Hisao Nishijo
Cognitive and socio-emotional deficits in platelet-derived growth factor receptor-β gene knockout mice.
PloS one 2011;6(3):e18004.
2010: Lianshun Zheng; Yoko Ishii; Ayano Tokunaga; Takeru Hamashima; Jie Shen; Qing-Li Zhao; Shin Ishizawa; Toshihiko Fujimori; Yo-Ichi Nabeshima; Hisashi Mori; Takashi Kondo; Masakiyo Sasahara
Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved.
Journal of neuroscience research 2010;88(6):1273-84.
2009: Takashi Yamazaki; Hemragul Sabit; Takeshi Oya; Yoko Ishii; Takeru Hamashima; Ayano Tokunaga; Shin Ishizawa; Shen Jie; Yoichi Kurashige; Takako Matsushima; Isao Furuta; Makoto Noguchi; Masakiyo Sasahara
Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves.
Journal of the peripheral nervous system : JPNS 2009;14(3):165-76.
2009: Hiroshi Kudo; Yutaka Yata; Terumi Takahara; Kengo Kawai; Yasuhiro Nakayama; Masami Kanayama; Takeshi Oya; Seiichi Morita; Masakiyo Sasahara; Derek A Mann; Toshiro Sugiyama
Telmisartan attenuates progression of steatohepatitis in mice: role of hepatic macrophage infiltration and effects on adipose tissue.
Liver international : official journal of the International Association for the Study of the Liver 2009;29(7):988-96.
2009: Hikari Suzuki; Ichiro Kato; Isao Usui; Ichiro Takasaki; Yoshiaki Tabuchi; Takeshi Oya; Koichi tsuneyama; Hiroshi Kawaguchi; Koichi Hiraga; Shin Takasawa; Hiroshi Okamoto; Kazuyuki Tobe; Masakiyo Sasahara
Characterization of diabetic nephropathy in CaM kinase IIalpha (Thr286Asp) transgenic mice.
Biochemical and biophysical research communications 2009;379(1):38-42.
2008: Ichiro Kato; Takeshi Oya; Hikari Suzuki; Kumi Takasawa; Andi M Ichsan; Shinji Nakada; Yoko Ishii; Yutaka Shimada; Masakiyo Sasahara; Kazuyuki Tobe; Shin Takasawa; Hiroshi Okamoto; Koichi Hiraga
A novel model of insulin-dependent diabetes with renal and retinal lesions by transgenic expression of CaMKIIalpha (Thr286Asp) in pancreatic beta-cells.
Diabetes/metabolism research and reviews 2008;24(6):486-97.
2008: Ayano Tokunaga; Takeshi Oya; Yoko Ishii; Hiraku Motomura; Chieko Nakamura; Shin Ishizawa; Toshihiko Fujimori; Yo-ichi Nabeshima; Akihiro Umezawa; Masahiko Kanamori; Tomoatsu Kimura; Masakiyo Sasahara
PDGF receptor beta is a potent regulator of mesenchymal stromal cell function.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008;23(9):1519-28.
2008: Jiro Ogawa; Hirokazu Kanegane; Koichi tsuneyama; Rika Kanezaki; Takeshi Futatani; Keiko Nomura; Shin Ishizawa; Masakiyo Sasahara; Etsuro Ito; Toshio Miyawaki
Platelet-derived growth factor may be associated with fibrosis in a Down syndrome patient with transient myeloproliferative disorder.
European journal of haematology 2008;81(1):58-64.
2008: Syota Kagawa; Yoshiyuki Soeda; Hajime Ishihara; Takeshi Oya; Masakiyo Sasahara; Saori Yaguchi; Ryo Oshita; Tsutomu Wada; Hiroshi Tsuneki; Toshiyasu Sasaoka
Impact of transgenic overexpression of SH2-containing inositol 5'-phosphatase 2 on glucose metabolism and insulin signaling in mice.
Endocrinology 2008;149(2):642-50.
2007: Yoshifumi Tsuboi; Nakamasa Hayashi; Masanori Kurimoto; Shoichi Nagai; Masakiyo Sasahara; Shunro Endo
Malignant transformation of clival chordoma after gamma knife surgery - case report - .
Neurologia medico-chirurgica 2007;47(10):479-82.
2007: Jun Tang; Teruaki Akao; Norio Nakamura; Zheng-Tao Wang; Kiyoshi Takagawa; Masakiyo Sasahara; Masao Hattori
In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1832-9.
2007: Yoshiaki Ohi; Yoko Ishii; Akira Haji; Shigeru Noguchi; Toshiyasu Sasaoka; Toshihiko Fujimori; Yo-ichi Nabeshima; Masakiyo Sasahara; Yuichi Hattori
Platelet-derived growth factor (PDGF)-BB inhibits AMPA receptor-mediated synaptic transmission via PDGF receptor-beta in murine nucleus tractus solitarius.
Brain research 2007;1159():77-85.
2006: Kazunori Hemmi; Dongping Ma; Yutaka Miura; Makoto Kawaguchi; Masakiyo Sasahara; Tomoko Hashimoto-Tamaoki; Taiki Tamaoki; Nobuo Sakata; Kayoko Tsuchiya
A homeodomain-zinc finger protein, ZFHX4, is expressed in neuronal differentiation manner and suppressed in muscle differentiation manner.
Biological & pharmaceutical bulletin 2006;29(9):1830-5.
2006: Yoko Ishii; Takeshi Oya; Lianshun Zheng; Zhiyang Gao; Makoto Kawaguchi; Hemragul Sabit; Takako Matsushima; Ayano Tokunaga; Shin Ishizawa; Etsuro Hori; Yo-ichi Nabeshima; Toshiyasu Sasaoka; Toshihiko Fujimori; Hisashi Mori; Masakiyo Sasahara
Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury.
Journal of neurochemistry 2006;98(2):588-600.
2005: Zhiyang Gao; Toshiyasu Sasaoka; Toshihiko Fujimori; Takeshi Oya; Yoko Ishii; Hemragul Sabit; Makoto Kawaguchi; Yoko Kurotaki; Maiko Naito; Tsutomu Wada; Shin Ishizawa; Masashi Kobayashi; Yo-ichi Nabeshima; Masakiyo Sasahara
Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing.
The Journal of biological chemistry 2005;280(10):9375-89.
2005: Shigeharu Nogami; Yoko Ishii; Makoto Kawaguchi; Nobuo Sakata; Takeshi Oya; Kiyoshi Takagawa; Masahiko Kanamori; Hemragul Sabit; Toshiyuki Obata; Tomoatsu Kimura; Masakiyo Sasahara
ZFH4 protein is expressed in many neurons of developing rat brain.
The Journal of comparative neurology 2005;482(1):33-49.
2004: Arjun H Banskota; Nhan Trung Nguyen; Yasuhiro Tezuka; Quan Le Tran; Takahiro Nobukawa; Youichi Kurashige; Masakiyo Sasahara; Shigetoshi Kadota
Secoisolariciresinol and isotaxiresinol inhibit tumor necrosis factor-alpha-dependent hepatic apoptosis in mice.
Life sciences 2004;74(22):2781-92.
2004: Nhan Trung Nguyen; Arjun H Banskota; Yasuhiro Tezuka; Quan Le Tran; Takahiro Nobukawa; Youichi Kurashige; Masakiyo Sasahara; Shigetoshi Kadota
Hepatoprotective effect of taxiresinol and (7'R)-7'-hydroxylariciresinol on D-galactosamine and lipopolysaccharide-induced liver injury in mice.
Planta medica 2004;70(1):29-33.
2003: Yoko Ishii; Makoto Kawaguchi; Kiyoshi Takagawa; Takeshi Oya; Shigeharu Nogami; Amane Tamura; Yutaka Miura; Akio Ido; Nobuo Sakata; Tomoko Hashimoto-Tamaoki; Tomoatsu Kimura; Takayoshi Saito; Taiki Tamaoki; Masakiyo Sasahara
ATBF1-A protein, but not ATBF1-B, is preferentially expressed in developing rat brain.
The Journal of comparative neurology 2003;465(1):57-71.
2003: Tohru Masuda; Hirofumi Ogawa; Takako Matsushima; Seiichi Kawamata; Masakiyo Sasahara; Kazunari Kuroda; Yasuhiro Suzuki; Yoshimi Takata; Mitsuaki Yamazaki; Fusao Takusagawa; Henry C Pitot
Localization and hormonal control of serine dehydratase during metabolic acidosis differ markedly from those of phosphoenolpyruvate carboxykinase in rat kidney.
The international journal of biochemistry & cell biology 2003;35(8):1234-47.
2003: Ying-Luan Zhao; Kiyoshi Takagawa; Takeshi Oya; Hong-Fa Yang; Zhi-Yang Gao; Makoto Kawaguchi; Yoko Ishii; Toshiyasu Sasaoka; Koji Owada; Isao Furuta; Masakiyo Sasahara
Active Src expression is induced after rat peripheral nerve injury.
Glia 2003;42(2):184-93.
2002: Takeshi Oya; Ying-Luan Zhao; Kiyoshi Takagawa; Makoto Kawaguchi; Kamon Shirakawa; Tadakazu Yamauchi; Masakiyo Sasahara
Platelet-derived growth factor-b expression induced after rat peripheral nerve injuries.
Glia 2002;38(4):303-12.
2001: M Kawaguchi; Y Miura; Akio Ido; T Morinaga; Nobuo Sakata; Takeshi Oya; Tomoko Hashimoto-Tamaoki; Masakiyo Sasahara; Fumitomo Koizumi; Taiki Tamaoki
DNA/RNA-dependent ATPase activity is associated with ATBF1, a multiple homeodomain-zinc finger protein.
Biochimica et biophysica acta 2001;1550(2):164-74.
2001: K Yamazaki; Akiko Kawai; M Kawaguchi; Yasuhide Hibino; Fang Li; Masakiyo Sasahara; Kazuhiro Tsukada; Koichi Hiraga
Simultaneous induction of galectin-3 phosphorylated on tyrosine residue, p21(WAF1/Cip1/Sdi1), and the proliferating cell nuclear antigen at a distinctive period of repair of hepatocytes injured by CCl4.
Biochemical and biophysical research communications 2001;280(4):1077-84.
2000: Nobuo Sakata; K Hemmi; M Kawaguchi; Y Miura; S Noguchi; D Ma; Masakiyo Sasahara; T Kato; M Hori; Taiki Tamaoki
The mouse ZFH-4 protein contains four homeodomains and twenty-two zinc fingers.
Biochemical and biophysical research communications 2000;273(2):686-93.