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Motoko Sasaki

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Maylee Hsu; Saya Igarashi; Motoko Sasaki; Yasunori Sato; Yasuni Nakanuma
KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas.
Chihiro Gandou; Kenichi Harada; Saya Igarashi; Hiroko Ikeda; Motoko Sasaki; Yasunori Sato; Yasuni Nakanuma
Hilar cholangiocarcinoma and pancreatic ductal adenocarcinoma share similar histopathologies, immunophenotypes, and development-related molecules.
Yasunori Sato; Motoko Sasaki; Kenichi Harada; Yasuni Nakanuma
Histological characteristics of biliary intraepithelial neoplasia-3 and intraepithelial spread of cholangiocarcinoma.

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2013: Maylee Hsu; Saya Igarashi; Motoko Sasaki; Yasunori Sato; Yasuni Nakanuma
KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas.
Cancer 2013;119(9):1669-74.
2013: Chihiro Gandou; Kenichi Harada; Saya Igarashi; Hiroko Ikeda; Motoko Sasaki; Yasunori Sato; Yasuni Nakanuma
Hilar cholangiocarcinoma and pancreatic ductal adenocarcinoma share similar histopathologies, immunophenotypes, and development-related molecules.
Human pathology 2013;44(5):811-21.
2013: Yasunori Sato; Motoko Sasaki; Kenichi Harada; Yasuni Nakanuma
Histological characteristics of biliary intraepithelial neoplasia-3 and intraepithelial spread of cholangiocarcinoma.
Virchows Archiv : an international journal of pathology 2013;462(4):421-7.
2013: Motoko Sasaki; Yasunori Sato; Masami Miyakoshi; Yasuni Nakanuma
Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis.
Liver international : official journal of the International Association for the Study of the Liver 2013;33(2):312-20.
2013: Motoko Sasaki; Yasunori Sato; Koichi tsuneyama; Norihide Yoneda; Takashi Matsubara; Kazuhiro Nomoto; Yasuni Nakanuma
Overexpression of enhancer of zeste homolog 2 and MUC1 may be related to malignant behaviour in intraductal papillary neoplasm of the bile duct.
Histopathology 2013;62(3):446-57.
2012: Motoko Sasaki; Yasunori Sato; Norihide Yoneda; Seiko Kitamura; Yasuni Nakanuma
A serum amyloid A-positive hepatocellular neoplasm arising in alcoholic cirrhosis: a previously unrecognized type of inflammatory hepatocellular tumor.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2012;25(12):1584-93.
2012: Takashi Matsubara; Osamu Matsui; Koichi Nakamura; Kazuhiro Nomoto; Motoko Sasaki; Yasunori Sato; Koichi tsuneyama; Toshifumi Gabata; Kenichi Harada; Yasuni Nakanuma
Immunohistochemical characteristics and malignant progression of hepatic cystic neoplasms in comparison with pancreatic counterparts.
Human pathology 2012;43(12):2177-86.
2012: Saya Igarashi; Hiroko Ikeda; Takashi Matsubara; Osamu Matsui; Motoko Sasaki; Yasunori Sato; Kenichi Harada; Yasuni Nakanuma
Bile duct expression of pancreatic and duodenal homeobox 1 in perihilar cholangiocarcinogenesis.
Histopathology 2012;61(2):266-76.
2012: Jing Xu; Norihide Yoneda; Eunsil Yu; Motoko Sasaki; Saya Igarashi; Hiroko Ikeda; Jihun Kim; Kazuto Kozaka; Takashi Matsubara; Osamu Matsui; Yasuni Nakanuma
Intrahepatic cholangiocarcinomas in cirrhosis are hypervascular in comparison with those in normal livers.
Liver international : official journal of the International Association for the Study of the Liver 2012;32(7):1156-64.
2012: Motoko Sasaki; Yasunori Sato; Masami Miyakoshi; Yasuni Nakanuma
A possible involvement of p62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis.
Liver international : official journal of the International Association for the Study of the Liver 2012;32(3):487-99.
2012: Motoko Sasaki; Yasunori Sato; Masami Miyakoshi; Yasuni Nakanuma
Autophagy may precede cellular senescence of bile ductular cells in ductular reaction in primary biliary cirrhosis.
Digestive diseases and sciences 2012;57(3):660-6.
2012: Motoko Sasaki; Yasuni Nakanuma
Overview of hepatocellular adenoma in Japan.
International journal of hepatology 2012;2012():648131.
2012: Motoko Sasaki; Yasuni Nakanuma
Novel approach to bile duct damage in primary biliary cirrhosis: participation of cellular senescence and autophagy.
International journal of hepatology 2012;2012():452143.
2011: Xiang Shan Ren; Motoko Sasaki; Yasunori Sato; Norihide Yoneda; Kenichi Harada; Zhen Hua Lin; Yasuni Nakanuma
Biliary infection may exacerbate biliary cystogenesis through the induction of VEGF in cholangiocytes of the polycystic kidney (PCK) rat.
The American journal of pathology 2011;179(6):2845-54.
2011: Motoko Sasaki; Yasunori Sato; Norihide Yoneda; Seiko Kitamura; Yasuni Nakanuma
Characterization of hepatocellular adenoma based on the phenotypic classification: The Kanazawa experience.
Hepatology research : the official journal of the Japan Society of Hepatology 2011;41(10):982-8.
2011: Mayumi Chiba; Hiroko Ikeda; Seiko Kitamura; Motoko Sasaki; Yasunori Sato; Yasuni Nakanuma
Participation of bile ductular cells in the pathological progression of non-alcoholic fatty liver disease.
Journal of clinical pathology 2011;64(7):564-70.
2011: Yasuni Nakanuma; Jing Xu; Kenichi Harada; Yasunori Sato; Motoko Sasaki; Hiroko Ikeda; Jihun Kim; Eunsil Yu
Pathological spectrum of intrahepatic cholangiocarcinoma arising in non-biliary chronic advanced liver diseases.
Pathology international 2011;61(5):298-305.
2011: Norihide Yoneda; Yasunori Sato; Azusa Kitao; Hiroko Ikeda; Seiko Sawada-Kitamura; Masami Miyakoshi; Kenichi Harada; Motoko Sasaki; Osamu Matsui; Yasuni Nakanuma
Epidermal growth factor induces cytokeratin 19 expression accompanied by increased growth abilities in human hepatocellular carcinoma.
Laboratory investigation; a journal of technical methods and pathology 2011;91(2):262-72.
2010: Yasuni Nakanuma; Yasunori Sato; Kenichi Harada; Motoko Sasaki; Jing Xu; Hiroko Ikeda
Pathological classification of intrahepatic cholangiocarcinoma based on a new concept.
World journal of hepatology 2010;2(12):419-27.
2010: Moustafa A Sakr; Takahisa Takino; Takahiro Domoto; Hiroshi Nakano; Richard W Wong; Motoko Sasaki; Yasuni Nakanuma; Hiroshi Sato
GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase.
Cancer science 2010;101(11):2368-74.
2010: Motoko Sasaki; Masami Miyakoshi; Yasunori Sato; Yasuni Nakanuma
Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis.
Journal of hepatology 2010;53(2):318-25.
2010: Yasunori Sato; Hidenobu Osaka; Kenichi Harada; Motoko Sasaki; Yasuni Nakanuma
Intraductal tubular neoplasm of the common bile duct.
Pathology international 2010;60(7):516-9.
2010: Yasunori Sato; Kenichi Harada; Keita Itatsu; Hiroko Ikeda; Yuko Kakuda; Syuji Shimomura; Xiang Shan Ren; Norihide Yoneda; Motoko Sasaki; Yasuni Nakanuma
Epithelial-mesenchymal transition induced by transforming growth factor-{beta}1/Snail activation aggravates invasive growth of cholangiocarcinoma.
The American journal of pathology 2010;177(1):141-52.
2010: Motoko Sasaki; Masami Miyakoshi; Yasunori Sato; Yasuni Nakanuma
Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis.
Laboratory investigation; a journal of technical methods and pathology 2010;90(6):835-43.
2010: Yasuni Nakanuma; Yoh Zen; Kenichi Harada; Hiroko Ikeda; Yasunori Sato; Takeshi Uehara; Motoko Sasaki
Tumorigenesis and phenotypic characteristics of mucin-producing bile duct tumors: an immunohistochemical approach.
Journal of hepato-biliary-pancreatic sciences 2010;17(3):211-22.
2010: Yasuni Nakanuma; Yoh Zen; Kenichi Harada; Motoko Sasaki; Akitaka Nonomura; Takeshi Uehara; Kenji Sano; Fukuo Kondo; Toshio Fukusato; Koichi tsuneyama; Masahiro Ito; Kenichi Wakasa; Minoru Nomoto; Hiroshi Minato; Hironori Haga; Masayoshi Kage; Hirohisa Yano; Joji Haratake; Shinichi Aishima; Tomoyuki Masuda; Hajime Aoyama; Aya Miyakawa-Hayashino; Toshiharu Matsumoto; Hayato Sanefuji; Hidenori Ojima; Tse-Ching Chen; Eunsil Yu; Ji-Hun Kim; Young Nyun Park; Wilson Tsui
Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens: Interobserver agreement.
Pathology international 2010;60(3):167-74.
2010: Motoko Sasaki; Hiroko Ikeda; Junpei Yamaguchi; Masami Miyakoshi; Yasunori Sato; Yasuni Nakanuma
Bile ductular cells undergoing cellular senescence increase in chronic liver diseases along with fibrous progression.
American journal of clinical pathology 2010;133(2):212-23.
2010: Junpei Yamaguchi; Motoko Sasaki; Yasunori Sato; Keita Itatsu; Kenichi Harada; Yoh Zen; Hiroko Ikeda; Yuji Nimura; Masato Nagino; Yasuni Nakanuma
Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma.
Cancer science 2010;101(2):355-62.
2010: Motoko Sasaki; Yasuni Nakanuma
Biliary epithelial apoptosis, autophagy, and senescence in primary biliary cirrhosis.
Hepatitis research and treatment 2010;2010():205128.
2009: Hiroko Ikeda; Motoko Sasaki; Yasunori Sato; Kenichi Harada; Yoh Zen; Takeshi Mitsui; Yasuni Nakanuma
Large cell change of hepatocytes in chronic viral hepatitis represents a senescent-related lesion.
Human pathology 2009;40(12):1774-82.
2009: Motoko Sasaki; Junpei Yamaguchi; Hiroko Ikeda; Keita Itatsu; Yasuni Nakanuma
Polycomb group protein Bmi1 is overexpressed and essential in anchorage-independent colony formation, cell proliferation and repression of cellular senescence in cholangiocarcinoma: tissue and culture studies.
Human pathology 2009;40(12):1723-30.
2009: Yasuni Nakanuma; Motoko Sasaki; Yasunori Sato; Xiangshan Ren; Hiroko Ikeda; Kenichi Harada
Multistep carcinogenesis of perihilar cholangiocarcinoma arising in the intrahepatic large bile ducts.
World journal of hepatology 2009;1(1):35-42.
2009: Junpei Yamaguchi; Motoko Sasaki; Kenichi Harada; Yoh Zen; Yasunori Sato; Hiroko Ikeda; Keita Itatsu; Yukihiro Yokoyama; Hisami Ando; Tetsuo Ohta; Akio Kubota; Koichi Shimizu; Yuji Nimura; Masato Nagino; Yasuni Nakanuma
Papillary hyperplasia of the gallbladder in pancreaticobiliary maljunction represents a senescence-related lesion induced by lysolecithin.
Laboratory investigation; a journal of technical methods and pathology 2009;89(9):1018-31.
2009: Azusa Kitao; Yasunori Sato; Seiko Sawada-Kitamura; Kenichi Harada; Motoko Sasaki; Hiroyasu Morikawa; Susumu Shiomi; Masao Honda; Osamu Matsui; Yasuni Nakanuma
Endothelial to mesenchymal transition via transforming growth factor-beta1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension.
The American journal of pathology 2009;175(2):616-26.
2009: Hiroko Ikeda; Motoko Sasaki; Yasunori Sato; Kenichi Harada; Yoh Zen; Takeshi Mitsui; Yasuni Nakanuma
Bile ductular cell reaction with senescent hepatocytes in chronic viral hepatitis is lost during hepatocarcinogenesis.
Pathology international 2009;59(7):471-8.
2009: Yasunori Sato; Munenori Mukai; Motoko Sasaki; Azusa Kitao; Norihide Yoneda; Daisuke Kobayashi; Yoshiaki Imamura; Yasuni Nakanuma
Intraductal papillary-mucinous neoplasm of the pancreas associated with polycystic liver and kidney disease.
Pathology international 2009;59(3):201-4.
2009: Keita Itatsu; Motoko Sasaki; Junpei Yamaguchi; Shusaku Ohira; Akira Ishikawa; Hiroko Ikeda; Yasunori Sato; Kenichi Harada; Yoh Zen; Hiroshi Sato; Tetsuo Ohta; Masato Nagino; Yuji Nimura; Yasuni Nakanuma
Cyclooxygenase-2 is involved in the up-regulation of matrix metalloproteinase-9 in cholangiocarcinoma induced by tumor necrosis factor-alpha.
The American journal of pathology 2009;174(3):829-41.
2009: Motoko Sasaki; Ichiro Araki; Toshiaki Yasui; Masaru Kinoshita; Keita Itatsu; Takayuki Nojima; Yasuni Nakanuma
Primary localized malignant biphasic mesothelioma of the liver in a patient with asbestosis.
World journal of gastroenterology : WJG 2009;15(5):615-21.
2009: Yasunori Sato; Kenichi Harada; Hiroko Ikeda; Takahiko Fijii; Motoko Sasaki; Yoh Zen; Yasuni Nakanuma
Hepatic stellate cells are activated around central scars of focal nodular hyperplasia of the liver--a potential mechanism of central scar formation.
Human pathology 2009;40(2):181-8.
2009: Keita Itatsu; Motoko Sasaki; Kenichi Harada; Junpei Yamaguchi; Hiroko Ikeda; Yasunori Sato; Tetsuo Ohta; Hiroshi Sato; Masato Nagino; Yuji Nimura; Yasuni Nakanuma
Phosphorylation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase and nuclear translocation of nuclear factor-kappaB are involved in upregulation of matrix metalloproteinase-9 by tumour necrosis factor-alpha.
Liver international : official journal of the International Association for the Study of the Liver 2009;29(2):291-8.
2008: Motoko Sasaki; Hiroko Ikeda; Keita Itatsu; Junpei Yamaguchi; Seiko Sawada; Hiroshi Minato; Tetsuo Ohta; Yasuni Nakanuma
The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma.
Laboratory investigation; a journal of technical methods and pathology 2008;88(8):873-82.
2008: Ryuhei Nishino; Masao Honda; Taro Yamashita; Hajime Takatori; Hiroshi Minato; Yoh Zen; Motoko Sasaki; Hiroyuki Takamura; Katsuhisa Horimoto; Tetsuo Ohta; Yasuni Nakanuma; Shuichi Kaneko
Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma.
Journal of hepatology 2008;49(2):207-16.
2008: Motoko Sasaki; Hiroko Ikeda; Yasuni Nakanuma
Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: an immunohistochemical study.
Journal of autoimmunity 2008;31(1):73-8.
2008: Motoko Sasaki; Hiroko Ikeda; Yasunori Sato; Yasuni Nakanuma
Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: a culture study.
Free radical research 2008;42(7):625-32.
2008: Motoko Sasaki; Hiroko Ikeda; Junpei Yamaguchi; Satoko Nakada; Yasuni Nakanuma
Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence.
Hepatology (Baltimore, Md.) 2008;48(1):186-95.
2008: Motoko Sasaki; J Yamaguchi; Keita Itatsu; Hiroko Ikeda; Yasuni Nakanuma
Over-expression of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis.
The Journal of pathology 2008;215(2):175-83.
2008: Keita Itatsu; Yoh Zen; Junpei Yamaguchi; Shusaku Ohira; Akira Ishikawa; Hiroko Ikeda; Yasunori Sato; Kenichi Harada; Motoko Sasaki; Masatoshi Sasaki; Hiroya Sakamoto; Masato Nagino; Yuji Nimura; Tetsuo Ohta; Yasuni Nakanuma
Expression of matrix metalloproteinase 7 is an unfavorable postoperative prognostic factor in cholangiocarcinoma of the perihilar, hilar, and extrahepatic bile ducts.
Human pathology 2008;39(5):710-9.
2008: Yasuni Nakanuma; Motoko Sasaki; Hiroko Ikeda; Yasunori Sato; Yoh Zen; Kazuto Kosaka; Kenichi Harada
Pathology of peripheral intrahepatic cholangiocarcinoma with reference to tumorigenesis.
Hepatology research : the official journal of the Japan Society of Hepatology 2008;38(4):325-34.
2008: Takahiko Fujii; Yoh Zen; Yasunori Sato; Motoko Sasaki; Mio Enomae; Hiroshi Minato; Shinji Masuda; Takeshi Uehara; Tsutomu Katsuyama; Yasuni Nakanuma
Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008;21(2):125-30.
2007: Yasunori Sato; Kenichi Harada; Satoru Ozaki; Shinichi Furubo; Kazuo Kizawa; Takahiro Sanzen; Mitsue Yasoshima; Hiroko Ikeda; Motoko Sasaki; Yasuni Nakanuma
Cholangiocytes with mesenchymal features contribute to progressive hepatic fibrosis of the polycystic kidney rat.
The American journal of pathology 2007;171(6):1859-71.
2007: Motoko Sasaki; Keita Itatsu; Hiroshi Minato; Hiroyuki Takamura; Tetsuo Ohta; Yasuni Nakanuma
Flare-up of nonalcoholic steatohepatitis after hepatectomy resulted in hepatic failure in a patient with type 2 diabetes mellitus.
Digestive diseases and sciences 2007;52(12):3473-6.
2007: Keita Itatsu; Yoh Zen; Shusaku Ohira; Akira Ishikawa; Yasunori Sato; Kenichi Harada; Hiroko Ikeda; Motoko Sasaki; Yuji Nimura; Yasuni Nakanuma
Immunohistochemical analysis of the progression of flat and papillary preneoplastic lesions in intrahepatic cholangiocarcinogenesis in hepatolithiasis.
Liver international : official journal of the International Association for the Study of the Liver 2007;27(9):1174-84.
2007: Hideki Niwa; Motoko Sasaki; Joji Haratake; Takahiko Kasai; Kazuyoshi Katayanagi; Hiroshi Kurumaya; Shinji Masuda; Hiroshi Minato; Yoh Zen; Akio Uchiyama; Atsuo Miwa; Katsuhiko Saito; Yoshiko Sudo; Yasuni Nakanuma
Clinicopathological significance of antinuclear antibodies in non-alcoholic steatohepatitis.
Hepatology research : the official journal of the Japan Society of Hepatology 2007;37(11):923-31.
2007: Seiko Sawada; Kenichi Harada; Kumiko Isse; Yasunori Sato; Motoko Sasaki; Yasuharu Kaizaki; Yasuni Nakanuma
Involvement of Escherichia coli in pathogenesis of xanthogranulomatous cholecystitis with scavenger receptor class A and CXCL16-CXCR6 interaction.
Pathology international 2007;57(10):652-63.
2007: Motoko Sasaki; Hiroko Ikeda; Seiko Sawada; Yasunori Sato; Yasuni Nakanuma
Naturally-occurring regulatory T cells are increased in inflamed portal tracts with cholangiopathy in primary biliary cirrhosis.
Journal of clinical pathology 2007;60(10):1102-7.
2007: Kazuto Kozaka; Motoko Sasaki; Takahiko Fujii; Kenichi Harada; Yoh Zen; Yasunori Sato; Seiko Sawada; Hiroshi Minato; Osamu Matsui; Yasuni Nakanuma
A subgroup of intrahepatic cholangiocarcinoma with an infiltrating replacement growth pattern and a resemblance to reactive proliferating bile ductules: 'bile ductular carcinoma'.
Histopathology 2007;51(3):390-400.
2007: Yasunori Sato; Seiko Sawada; Kazuto Kozaka; Kenichi Harada; Motoko Sasaki; Osamu Matsui; Yasuni Nakanuma
Significance of enhanced expression of nitric oxide syntheses in splenic sinus lining cells in altered portal hemodynamics of idiopathic portal hypertension.
Digestive diseases and sciences 2007;52(8):1987-94.
2007: Yoh Zen; N Volkan Adsay; Krystof Bardadin; Romano Colombari; Linda Ferrell; Hironori Haga; Seung-Mo Hong; Prodromos Hytiroglou; Günter Klöppel; Gregory Y Lauwers; Dirk J van Leeuwen; Kenji Notohara; Kiyoko Oshima; Alberto Quaglia; Motoko Sasaki; Fausto Sessa; Arief Suriawinata; Wilson M S Tsui; Yutaka Atomi; Yasuni Nakanuma
Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2007;20(6):701-9.
2007: Hiroko Ikeda; Motoko Sasaki; Akira Ishikawa; Yasunori Sato; Kenichi Harada; Yoh Zen; Hideaki Kazumori; Yasuni Nakanuma
Interaction of Toll-like receptors with bacterial components induces expression of CDX2 and MUC2 in rat biliary epithelium in vivo and in culture.
Laboratory investigation; a journal of technical methods and pathology 2007;87(6):559-71.
2007: Keita Itatsu; Takahiko Fujii; Motoko Sasaki; Yoh Zen; Yasuni Nakanuma
Intraductal papillary cholangiocarcinoma and atypical biliary epithelial lesions confused with intrabiliary extension of metastatic colorectal carcinoma.
Hepato-gastroenterology 2007;54(75):677-80.
2007: Motoko Sasaki; Hiroko Ikeda; Yasuni Nakanuma
Expression profiles of MUC mucins and trefoil factor family (TFF) peptides in the intrahepatic biliary system: physiological distribution and pathological significance.
Progress in histochemistry and cytochemistry 2007;42(2):61-110.
2006: Yasunori Sato; Kenichi Harada; Shinichi Furubo; Kazuo Kizawa; Takahiro Sanzen; Mitsue Yasoshima; Satoru Ozaki; Kumiko Isse; Motoko Sasaki; Yasuni Nakanuma
Inhibition of intrahepatic bile duct dilation of the polycystic kidney rat with a novel tyrosine kinase inhibitor gefitinib.
The American journal of pathology 2006;169(4):1238-50.
2006: Motoko Sasaki; Hiroko Ikeda; Hiroaki Kataoka; Yasuni Nakanuma
Augmented expression of hepatocytes growth factor activator inhibitor type 1 (HAI-1) in intrahepatic small bile ducts in primary biliary cirrhosis.
Virchows Archiv : an international journal of pathology 2006;449(4):462-71.
2006: Motoko Sasaki; Hiroko Ikeda; Yasunori Sato; Yasuni Nakanuma
Decreased expression of Bmi1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis.
The American journal of pathology 2006;169(3):831-45.
2006: Shusaku Ohira; Keita Itatsu; Motoko Sasaki; Kenichi Harada; Yasunori Sato; Yoh Zen; Akira Ishikawa; Koji Oda; Tetsuro Nagasaka; Yuji Nimura; Yasuni Nakanuma
Local balance of transforming growth factor-beta1 secreted from cholangiocarcinoma cells and stromal-derived factor-1 secreted from stromal fibroblasts is a factor involved in invasion of cholangiocarcinoma.
Pathology international 2006;56(7):381-9.
2006: Shusaku Ohira; Motoko Sasaki; Kenichi Harada; Yasunori Sato; Yoh Zen; Kumiko Isse; Kazuto Kozaka; Akira Ishikawa; Koji Oda; Yuji Nimura; Yasuni Nakanuma
Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumor necrosis factor-alpha and stromal-derived factor-1 released in stroma.
The American journal of pathology 2006;168(4):1155-68.
2006: Yoh Zen; Motoko Sasaki; Takahiko Fujii; Tse-Ching Chen; Miin-Fu Chen; Ta-Sen Yeh; Yi-Yin Jan; Shiu-Feng Huang; Yuji Nimura; Yasuni Nakanuma
Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct--an immunohistochemical study of 110 cases of hepatolithiasis.
Journal of hepatology 2006;44(2):350-8.
2005: Satoshi Kitagawa; Yoh Zen; Kenichi Harada; Motoko Sasaki; Yasunori Sato; Hiroshi Minato; Kishichiro Watanabe; Hiroshi Kurumaya; Kazuyoshi Katayanagi; Shinji Masuda; Hideki Niwa; Koichi tsuneyama; Katsuhiko Saito; Joji Haratake; Kiyoshi Takagawa; Yasuni Nakanuma
Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Küttner's tumor).
The American journal of surgical pathology 2005;29(6):783-91.
2005: Yoh Zen; Shinichi Aishima; Yoichi Ajioka; Joji Haratake; Masayoshi Kage; Fukuo Kondo; Yuji Nimura; Michiie Sakamoto; Motoko Sasaki; Kazuhide Shimamatsu; Kenichi Wakasa; Young Nyun Park; Ming F Chen; Yutaka Atomi; Yasuni Nakanuma
Proposal of histological criteria for intraepithelial atypical/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma: preliminary report based on interobserver agreement.
Pathology international 2005;55(4):180-8.
2005: Yoh Zen; Kenichi Harada; Motoko Sasaki; Tse-Ching Chen; Miin-Fu Chen; Ta-Sen Yeh; Yi-Yin Jan; Shiu-Feng Huang; Yuji Nimura; Yasuni Nakanuma
Intrahepatic cholangiocarcinoma escapes from growth inhibitory effect of transforming growth factor-beta1 by overexpression of cyclin D1.
Laboratory investigation; a journal of technical methods and pathology 2005;85(4):572-81.
2005: Kaoru Sugimori; Katsuji Kobayashi; Masahiro Hayashi; Naoto Sakai; Motoko Sasaki; Yoshifumi Koshino
Leptomeningeal carcinomatosis from urinary bladder adenocarcinoma: a clinicopathological case study.
Neuropathology : official journal of the Japanese Society of Neuropathology 2005;25(1):89-94.
2005: Motoko Sasaki; Hiroko Ikeda; Hironori Haga; Toshiaki Manabe; Yasuni Nakanuma
Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss.
The Journal of pathology 2005;205(4):451-9.
2005: Yoh Zen; Kenichi Harada; Motoko Sasaki; Koichi tsuneyama; Kazuhiro Matsui; Joji Haratake; Shotaro Sakisaka; Shiro Maeyama; Kazuhide Yamamoto; Masayuki Nakano; Kazuhide Shimamatsu; Masayoshi Kage; Nozomu Kurose; Akio Uchiyama; Yasuharu Kaizaki; Gotaro Toda; Yasuni Nakanuma
Are bile duct lesions of primary biliary cirrhosis distinguishable from those of autoimmune hepatitis and chronic viral hepatitis? Interobserver histological agreement on trimmed bile ducts.
Journal of gastroenterology 2005;40(2):164-70.
2004: Akira Ishikawa; Motoko Sasaki; Yasunori Sato; Shusaku Ohira; Miin-Fu Chen; Shiu-Feng Huang; Koji Oda; Yuji Nimura; Yasuni Nakanuma
Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis.
Human pathology 2004;35(12):1505-14.
2004: Yoh Zen; Kenichi Harada; Motoko Sasaki; Yasunori Sato; Koichi tsuneyama; Joji Haratake; Hiroshi Kurumaya; Kazuyoshi Katayanagi; Shinji Masuda; Hideki Niwa; Hideo Morimoto; Atsuo Miwa; Akio Uchiyama; Bernard C Portmann; Yasuni Nakanuma
IgG4-related sclerosing cholangitis with and without hepatic inflammatory pseudotumor, and sclerosing pancreatitis-associated sclerosing cholangitis: do they belong to a spectrum of sclerosing pancreatitis?
The American journal of surgical pathology 2004;28(9):1193-203.
2004: Motoko Sasaki; Hiroko Ikeda; Shusaku Ohira; Akira Ishikawa; Yasuni Nakanuma
Expression of trefoil factor family 1, 2, and 3 peptide is augmented in hepatolithiasis.
Peptides 2004;25(5):763-70.
2004: Akira Ishikawa; Motoko Sasaki; Shusaku Ohira; Tetsuo Ohta; Koji Oda; Yuji Nimura; Miin-Fu Chen; Yi-Yin Jan; Ta-Sen Yeh; Yasuni Nakanuma
Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis.
Laboratory investigation; a journal of technical methods and pathology 2004;84(5):629-38.
2004: Koichi tsuneyama; Motoko Sasaki; Tomonori Shimonishi; Yasuni Nakanuma
Expression of MAGE-A3 in intrahepatic cholangiocarcinoma and its precursor lesions.
Pathology international 2004;54(3):181-6.
2004: Motoko Sasaki; Koichi tsuneyama; Takahito Saito; Hiroaki Kataoka; Jan Mollenhauer; Annemarie Poustka; Yasuni Nakanuma
Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology.
Liver international : official journal of the International Association for the Study of the Liver 2004;24(1):29-37.
2003: Motoko Sasaki; Koichi tsuneyama; Akira Ishikawa; Yasuni Nakanuma
Intrahepatic cholangiocarcinoma in cirrhosis presents granulocyte and granulocyte-macrophage colony-stimulating factor.
Human pathology 2003;34(12):1337-44.
2003: Motoko Sasaki; Koichi tsuneyama; Yasuni Nakanuma
Aberrant expression of trefoil factor family 1 in biliary epithelium in hepatolithiasis and cholangiocarcinoma.
Laboratory investigation; a journal of technical methods and pathology 2003;83(10):1403-13.
2003: Motoko Sasaki; Shiu-Feng Huang; Miin-Fu Chen; Yi-Yin Jan; Ta-Sen Yeh; Akira Ishikawa; Jan Mollenhauer; Annemarie Poustka; Koichi tsuneyama; Yuji Nimura; Koji Oda; Yasuni Nakanuma
Decrease of deleted in malignant brain tumour-1 (DMBT-1) expression is a crucial late event in intrahepatic cholangiocarcinoma.
Histopathology 2003;43(4):340-6.
2003: Motoko Sasaki; Shiu-Feng Huang; Miin-Fu Chen; Yi-Yin Jan; Ta-Sen Yeh; Akira Ishikawa; Jan Mollenhauer; Annemarie Poustka; Koichi tsuneyama; Yuji Nimura; Koji Oda; Yasuni Nakanuma
Expression of deleted in malignant brain tumor-1 (DMBT1) molecule in biliary epithelium is augmented in hepatolithiasis: possible participation in lithogenesis.
Digestive diseases and sciences 2003;48(7):1234-40.
2003: Koichi tsuneyama; Yasuharu Kaizaki; Kenji Doden; Eiichi Kidani; Kenichi Harada; Motoko Sasaki; Yasuni Nakanuma
Combined hepatocellular and cholangiocarcinoma with marked squamous cell carcinoma components arising in non-cirrhotic liver.
Pathology international 2003;53(2):90-7.
2003: Yasuni Nakanuma; Kenichi Harada; Akira Ishikawa; Yoh Zen; Motoko Sasaki
Anatomic and molecular pathology of intrahepatic cholangiocarcinoma.
Journal of hepato-biliary-pancreatic surgery 2003;10(4):265-81.
2002: Yoh Zen; Kenichi Harada; Motoko Sasaki; Koichi tsuneyama; Kazuyoshi Katayanagi; Yui Yamamoto; Yasuni Nakanuma
Lipopolysaccharide induces overexpression of MUC2 and MUC5AC in cultured biliary epithelial cells: possible key phenomenon of hepatolithiasis.
The American journal of pathology 2002;161(4):1475-84.
2002: Koichi tsuneyama; Kenichi Harada; Naoko Kono; Motoko Sasaki; Takahito Saito; M Eric Gershwin; Mamoru Ikemoto; Hiroyuki Arai; Yasuni Nakanuma
Damaged interlobular bile ducts in primary biliary cirrhosis show reduced expression of glutathione-S-transferase-pi and aberrant expression of 4-hydroxynonenal.
Journal of hepatology 2002;37(2):176-83.
2002: Yasuni Nakanuma; Motoko Sasaki; Akira Ishikawa; W Tsui; Tse-Ching Chen; S F Huang
Biliary papillary neoplasm of the liver.
Histology and histopathology 2002;17(3):851-61.
2002: Takahito Saito; Kenichi Harada; Koichi tsuneyama; Masaaki Hirano; Susumu Amaya; Motoko Sasaki; Shuichi Kaneko; Kenichi Kobayashi; Yasuni Nakanuma
Primary squamous cell carcinoma of the liver producing parathyroid hormone-related protein.
Journal of gastroenterology 2002;37(2):138-42.
2001: Susumu Amaya; Motoko Sasaki; Y Watanabe; Wilson M S Tsui; Koichi tsuneyama; Kenichi Harada; Yasuni Nakanuma
Expression of MUC1 and MUC2 and carbohydrate antigen Tn change during malignant transformation of biliary papillomatosis.
Histopathology 2001;38(6):550-60.
2001: M Iwata; Motoko Sasaki; Kenichi Harada; Shuichi Kaneko; K i Kobayashi; K Adachi; M Sasaki; Yasuni Nakanuma
Intrahepatic cholangitis and arteritis after transcatheter arterial embolization in a patient with tumor-like lesion-associated autoimmune hepatitis.
Pathology, research and practice 2001;197(1):59-63.
2000: Yasuni Nakanuma; Koichi tsuneyama; Motoko Sasaki; Kenichi Harada
Destruction of bile ducts in primary biliary cirrhosis.
Baillière's best practice & research. Clinical gastroenterology 2000;14(4):549-70.
2000: Wataru Koda; Kenichi Harada; Koichi tsuneyama; Naoko Kono; Motoko Sasaki; Osamu Matsui; Yasuni Nakanuma
Evidence of the participation of peribiliary mast cells in regulation of the peribiliary vascular plexus along the intrahepatic biliary tree.
Laboratory investigation; a journal of technical methods and pathology 2000;80(7):1007-17.
2000: Katsushi Hiramatsu; Kenichi Harada; Koichi tsuneyama; Motoko Sasaki; S Fujita; T Hashimoto; Shuichi Kaneko; K i Kobayashi; Yasuni Nakanuma
Amplification and sequence analysis of partial bacterial 16S ribosomal RNA gene in gallbladder bile from patients with primary biliary cirrhosis.
Journal of hepatology 2000;33(1):9-18.
2000: Tomonori Shimonishi; Motoko Sasaki; Yasuni Nakanuma
Precancerous lesions of intrahepatic cholangiocarcinoma.
Journal of hepato-biliary-pancreatic surgery 2000;7(6):542-50.
2000: Mitsue Yasoshima; Koichi tsuneyama; Kenichi Harada; Motoko Sasaki; M Eric Gershwin; Yasuni Nakanuma
Immunohistochemical analysis of cell-matrix adhesion molecules and their ligands in the portal tracts of primary biliary cirrhosis.
The Journal of pathology 2000;190(1):93-9.
1999: Koichi tsuneyama; Naoko Kono; Masashi Yamashiro; Wataru Kouda; A Sabit; Motoko Sasaki; Yasuni Nakanuma
Aberrant expression of stem cell factor on biliary epithelial cells and peribiliary infiltration of c-kit-expressing mast cells in hepatolithiasis and primary sclerosing cholangitis: a possible contribution to bile duct fibrosis.
The Journal of pathology 1999;189(4):609-14.
1999: T Yamato; H Kurumaya; K Ohama; N Yamamichi; Y Watanabe; Kenichi Harada; Motoko Sasaki; Yasuni Nakanuma
Frequent expression of mucin core protein MUC1 in non-neoplastic gallbladder mucosa from patients with pancreaticobiliary maljunction.
Liver 1999;19(4):281-7.
1999: T Yamato; Motoko Sasaki; Y Watanabe; Yasuni Nakanuma
Expression of MUC1 and MUC2 mucin core proteins and their messenger RNA in gall bladder carcinoma: an immunohistochemical and in situ hybridization study.
The Journal of pathology 1999;188(1):30-7.
1999: Motoko Sasaki; T Yamato; Yasuni Nakanuma
Expression of sialyl-Tn, Tn and T antigens in primary liver cancer.
Pathology international 1999;49(4):325-31.
1999: Yasuni Nakanuma; Kenichi Harada; Kazuyoshi Katayanagi; Koichi tsuneyama; Motoko Sasaki
Definition and pathology of primary sclerosing cholangitis.
Journal of hepato-biliary-pancreatic surgery 1999;6(4):333-42.
1999: Motoko Sasaki; T Yamato; Yasuni Nakanuma; S B Ho; Y S Kim
Expression of MUC2, MUC5AC and MUC6 apomucins in carcinoma, dysplasia and non-dysplastic epithelia of the gallbladder.
Pathology international 1999;49(1):38-44.
1999: Koichi tsuneyama; Motoko Sasaki; A Sabit; K Yokoi; Y Arano; T Imai; Yasuni Nakanuma
A case report of gastric carcinosarcoma with rhabdomyosarcomatous and neuroendocrinal differentiation.
Pathology, research and practice 1999;195(2):93-7; discussion 98.
1998: Motoko Sasaki; Yasuni Nakanuma; H Ando
Lipomatous pseudohypertrophy of the pancreas in a patient with cirrhosis due to chronic hepatitis B.
Pathology international 1998;48(7):566-8.
1998: Motoko Sasaki; Yasuni Nakanuma; S B Ho; YS Kim
Increased MUC6 apomucin expression is a characteristic of reactive biliary epithelium in chronic viral hepatitis.
The Journal of pathology 1998;185(2):191-8.
1998: T Yamato; Motoko Sasaki; M Hoso; J Sakai; Hajime Ohta; Y Watanabe; Yasuni Nakanuma
Intrahepatic cholangiocarcinoma arising in congenital hepatic fibrosis: report of an autopsy case.
Journal of hepatology 1998;28(4):717-22.
1998: Motoko Sasaki; Yasuni Nakanuma; S B Ho; YS Kim
Cholangiocarcinomas arising in cirrhosis and combined hepatocellular-cholangiocellular carcinomas share apomucin profiles.
American journal of clinical pathology 1998;109(3):302-8.
1998: Motoko Sasaki; Yasuni Nakanuma; YS Kim
Expression of apomucins in the intrahepatic biliary tree in hepatolithiasis differs from that in normal liver and extrahepatic biliary obstruction.
Hepatology (Baltimore, Md.) 1998;27(1):54-61.
1997: Yasuni Nakanuma; M Hoso; Takahiro Sanzen; Motoko Sasaki
Microstructure and development of the normal and pathologic biliary tract in humans, including blood supply.
Microscopy research and technique 1997;38(6):552-70.
1997: Kyosuke Kaji; Koichi tsuneyama; Yasuni Nakanuma; Kenichi Harada; Motoko Sasaki; Shuichi Kaneko; K i Kobayashi
B7-2 positive cells around interlobular bile ducts in primary biliary cirrhosis and chronic hepatitis C.
Journal of gastroenterology and hepatology 1997;12(7):507-12.
1996: Motoko Sasaki; Yasuni Nakanuma; Y S Kim
Characterization of apomucin expression in intrahepatic cholangiocarcinomas and their precursor lesions: an immunohistochemical study.
Hepatology (Baltimore, Md.) 1996;24(5):1074-8.
1996: T Terada; T Ohta; Motoko Sasaki; Yasuni Nakanuma; Y S Kim
Expression of MUC apomucins in normal pancreas and pancreatic tumours.
The Journal of pathology 1996;180(2):160-5.
1996: Motoko Sasaki; Yasuni Nakanuma
Abnormal expression of MUC1 apomucin and mature MUC1 mucin in biliary epithelial cells in various cystic liver diseases.
Hepatology (Baltimore, Md.) 1996;24(3):539-43.
1996: Motoko Sasaki; Yasuni Nakanuma
Frequent expression of MUC1 apomucin on biliary epithelial cells of damaged small bile ducts in primary biliary cirrhosis and chronic viral hepatitis: an immunohistochemical study.
Hepatology (Baltimore, Md.) 1996;23(6):1313-7.
1996: Yasuni Nakanuma; M Hoso; Motoko Sasaki; T Terada; Kazuyoshi Katayanagi; Akitaka Nonomura; Hiroshi Kurumaya; A Harada; H Obata
Histopathology of the liver in non-cirrhotic portal hypertension of unknown aetiology.
Histopathology 1996;28(3):195-204.
1996: Motoko Sasaki; T Morita; M Hoso; Yasuni Nakanuma; H Tanimura
Carcinoembryonic antigen and blood group-related carbohydrate antigens in glycoproteins in human bile in hepatolithiasis. Japanese Study Group of Hepatolithiasis.
Hepatology (Baltimore, Md.) 1996;23(2):258-63.
1995: Motoko Sasaki; Yasuni Nakanuma; Koichi Shimizu; R Izumi
Pathological and immunohistochemical findings in a case of mucinous cholangiocarcinoma.
Pathology international 1995;45(10):781-6.
1995: Motoko Sasaki; Yasuni Nakanuma; T Terada; Y S Kim
Biliary epithelial expression of MUC1, MUC2, MUC3 and MUC5/6 apomucins during intrahepatic bile duct development and maturation. An immunohistochemical study.
The American journal of pathology 1995;147(3):574-9.
1995: Takahiro Sanzen; K Yoshida; Motoko Sasaki; T Terada; Yasuni Nakanuma
Expression of glycoconjugates during intrahepatic bile duct development in the rat: an immunohistochemical and lectin-histochemical study.
Hepatology (Baltimore, Md.) 1995;22(3):944-51.
1995: Motoko Sasaki; Yasuni Nakanuma; K Watanabe
Hepatocellular prolapse of hepatic portal tracts and subendothelial space of central veins in idiopathic portal hypertension.
Histopathology 1995;27(1):67-70.
1995: Motoko Sasaki; T Terada; Yasuni Nakanuma
[Mucinous cholangiocarcinoma].
Ryōikibetsu shōkōgun shirīzu 1995;(7):423-5.
1995: Motoko Sasaki; T Terada; Yasuni Nakanuma
[Intrahepatic sarcomatoid cholangiocarcinoma].
Ryōikibetsu shōkōgun shirīzu 1995;(7):408-10.
1994: Kyosuke Kaji; Yasuni Nakanuma; Motoko Sasaki; M Unoura; K Kobayashi; Akitaka Nonomura; Koichi tsuneyama; Judith A van de Water; M Eric Gershwin
Hepatitic bile duct injuries in chronic hepatitis C: histopathologic and immunohistochemical studies.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1994;7(9):937-45.
1994: Motoko Sasaki; Yasuni Nakanuma
Expression of mucin core protein of mammary type in primary liver cancer.
Hepatology (Baltimore, Md.) 1994;20(5):1192-7.
1994: Noboru Terayama; K P Makimoto; Satoshi Kobayashi; Yasuni Nakanuma; Motoko Sasaki; K Saito; Kazuyoshi Katayanagi
Pathology of the spleen in primary biliary cirrhosis: an autopsy study.
Pathology international 1994;44(10-11):753-8.
1994: Motoko Sasaki; K Harada; Yasuni Nakanuma; K Watanabe
Pseudolipoma of Glisson's capsule. Report of six cases and review of the literature.
Journal of clinical gastroenterology 1994;19(1):75-8.
1994: Motoko Sasaki; Naoko Kono; Yasuni Nakanuma
Membranous expression of Lewis Y antigen in clustered hepatocytes in chronic viral, autoimmune, and alcoholic liver diseases but not in biliary diseases.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1994;7(3):339-46.
1994: Yasuni Nakanuma; Motoko Sasaki; T Terada; Kenichi Harada
Intrahepatic peribiliary glands of humans. II. Pathological spectrum.
Journal of gastroenterology and hepatology 1994;9(1):80-6.
1994: Motoko Sasaki; Naoko Kono; Yasuni Nakanuma
Neoexpression of Lewis Y antigen is a sensitive phenotypic change of the damaged intrahepatic bile ducts.
Hepatology (Baltimore, Md.) 1994;19(1):138-44.
1993: Yasuni Nakanuma; Motoko Sasaki; Naoko Kono
Succinylated wheat germ agglutinin lectin binding in intrahepatic vessels. A new histochemical tool.
Archives of pathology & laboratory medicine 1993;117(8):809-11.
1991: Motoko Sasaki; Yasuni Nakanuma; Y Nagai; Akitaka Nonomura
Intrahepatic cholangiocarcinoma with sarcomatous transformation: an autopsy case.
Journal of clinical gastroenterology 1991;13(2):220-5.
1990: Motoko Sasaki; Yasuni Nakanuma; T Terada; M Hoso; K Saito; M Hayashi; Hiroshi Kurumaya
Amyloid deposition in intrahepatic large bile ducts and peribiliary glands in systemic amyloidosis.
Hepatology (Baltimore, Md.) 1990;12(4 Pt 1):743-6.
1990: Motoko Sasaki; T Terada; Yasuni Nakanuma; N Kono; Y Kasahara; K Watanabe
Anorectal mucinous adenocarcinoma associated with latent perianal Paget's disease.
The American journal of gastroenterology 1990;85(2):199-202.
1989: Yasuni Nakanuma; Motoko Sasaki
Expression of blood group-related antigens in the intrahepatic biliary tree and hepatocytes in normal livers and various hepatobiliary diseases.
Hepatology (Baltimore, Md.) 1989;10(2):174-8.