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Makoto Sasaki

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TOP 3
Haruhiko Fuwa; Kana Mizunuma; Makoto Sasaki; Takaya Suzuki; Hiroshi Kubo
Total synthesis and biological evaluation of (-)-exiguolide analogues: importance of the macrocyclic backbone.
Kazuya Ishigai; Mari Yotsu-Yamashita; Yuko Cho; Ryo Fukazawa; Haruhiko Fuwa; Keisuke Hashizume; Makoto Sasaki
Total synthesis and biological evaluation of (+)-gambieric acid A and its analogues.
Haruhiko Fuwa; Asami Saito; Naoya Yamagata; Makoto Sasaki
Total synthesis of 13-demethyllyngbyaloside B.

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All Publications

2013: Haruhiko Fuwa; Kana Mizunuma; Makoto Sasaki; Takaya Suzuki; Hiroshi Kubo
Total synthesis and biological evaluation of (-)-exiguolide analogues: importance of the macrocyclic backbone.
Organic & biomolecular chemistry 2013;11(21):3442-50.
2013: Kazuya Ishigai; Mari Yotsu-Yamashita; Yuko Cho; Ryo Fukazawa; Haruhiko Fuwa; Keisuke Hashizume; Makoto Sasaki
Total synthesis and biological evaluation of (+)-gambieric acid A and its analogues.
Chemistry (Weinheim an der Bergstrasse, Germany) 2013;19(17):5276-88.
2013: Haruhiko Fuwa; Asami Saito; Naoya Yamagata; Makoto Sasaki
Total synthesis of 13-demethyllyngbyaloside B.
Organic letters 2013;15(7):1630-3.
2012: Haruhiko Fuwa; Takuma Noguchi; Kenkichi Noto; Makoto Sasaki
Tandem catalysis in domino olefin cross-metathesis/intramolecular oxa-conjugate cyclization: concise synthesis of 2,6-cis-substituted tetrahydropyran derivatives.
Organic & biomolecular chemistry 2012;10(40):8108-12.
2012: Haruhiko Fuwa; Keisuke Hashizume; Kazuya Ishigai; Makoto Sasaki
Total synthesis and complete stereostructure of gambieric acid A.
Journal of the American Chemical Society 2012;134(29):11984-7.
2012: Yusuke Kasai; Takanori Ito; Makoto Sasaki
Total synthesis of (-)-polycavernoside A: Suzuki-Miyaura coupling approach.
Organic letters 2012;14(12):3186-9.
2012: Haruhiko Fuwa; Naoki Ichinokawa; Kenkichi Noto; Makoto Sasaki
Stereoselective synthesis of 2,6-cis-substituted tetrahydropyrans: Brønsted acid-catalyzed intramolecular oxa-conjugate cyclization of α,β-unsaturated ester surrogates.
The Journal of organic chemistry 2012;77(6):2588-607.
2011: Makoto Ebine; Haruhiko Fuwa; Makoto Sasaki
Total synthesis of (-)-brevenal: a streamlined strategy for practical synthesis of polycyclic ethers.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(49):13754-61.
2011: Haruhiko Fuwa; Kenkichi Noto; Makoto Sasaki
Biosynthesis-inspired intramolecular oxa-conjugate cyclization of α,β-unsaturated thioesters: stereoselective synthesis of 2,6-cis-substituted tetrahydropyrans.
Organic letters 2011;13(7):1820-3.
2011: Haruhiko Fuwa; Motohiro Nakajima; Jinglu Shi; Yoshiyuki Takeda; Tomoyuki Saito; Makoto Sasaki
A convergent synthesis of the C1-C16 segment of goniodomin A via palladium-catalyzed organostannane-thioester coupling.
Organic letters 2011;13(5):1106-9.
2011: Haruhiko Fuwa; Takaya Suzuki; Hiroshi Kubo; Takao Yamori; Makoto Sasaki
Total synthesis and biological assessment of (-)-exiguolide and analogues.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(9):2678-88.
2010: Haruhiko Fuwa; Sayaka Noji; Makoto Sasaki
Convergent assembly of the spiroacetal subunit of didemnaketal B.
Organic letters 2010;12(22):5354-7.
2010: Haruhiko Fuwa; Sayaka Noji; Makoto Sasaki
Studies toward the total synthesis of gambieric acids: stereocontrolled synthesis of a DEFG-ring model compound.
The Journal of organic chemistry 2010;75(15):5072-82.
2010: M B Gill; S Frausto; M Ikoma; Makoto Sasaki; M Oikawa; Ryuichi Sakai; Geoffrey T Swanson
A series of structurally novel heterotricyclic alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor-selective antagonists.
British journal of pharmacology 2010;160(6):1417-29.
2010: Haruhiko Fuwa; Hiroshi Yamaguchi; Makoto Sasaki
A unified total synthesis of aspergillides A and B.
Organic letters 2010;12(8):1848-51.
2010: Haruhiko Fuwa; Asami Saito; Makoto Sasaki
A concise total synthesis of (+)-neopeltolide.
Angewandte Chemie (International ed. in English) 2010;49(17):3041-4.
2010: Haruhiko Fuwa; Kenkichi Noto; Makoto Sasaki
Stereoselective synthesis of substituted tetrahydropyrans via domino olefin cross-metathesis/intramolecular oxa-conjugate cyclization.
Organic letters 2010;12(7):1636-9.
2010: L Leanne Lash-Van Wyhe; Pekka A Postila; Koichi Tsubone; Makoto Sasaki; Olli Pentikäinen; Ryuichi Sakai; Geoffrey T Swanson
Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine.
Neuropharmacology 2010;58(3):640-9.
2010: Haruhiko Fuwa; Makoto Sasaki
Total synthesis of (-)-exiguolide.
Organic letters 2010;12(3):584-7.
2010: Makoto Ebine; Yuto Suga; Haruhiko Fuwa; Makoto Sasaki
Highly efficient synthesis of medium-sized lactones via oxidative lactonization: concise total synthesis of isolaurepan.
Organic & biomolecular chemistry 2010;8(1):39-42.
2009: Haruhiko Fuwa; Asami Saito; Shinya Naito; Keiichi Konoki; Mari Yotsu-Yamashita; Makoto Sasaki
Total synthesis and biological evaluation of (+)-neopeltolide and its analogues.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(46):12807-18.
2009: Tomoyuki Saito; Haruhiko Fuwa; Makoto Sasaki
Toward the total synthesis of goniodomin A, an actin-targeting marine polyether macrolide: convergent synthesis of the C15-C36 segment.
Organic letters 2009;11(22):5274-7.
2009: Haruhiko Fuwa; Kazuya Ishigai; Tomomi Goto; Akihiro Suzuki; Makoto Sasaki
Synthetic studies on gambieric acids, potent antifungal polycyclic ether natural products: reassignment of the absolute configuration of the nonacyclic polyether core by NMR analysis of model compounds.
The Journal of organic chemistry 2009;74(11):4024-40.
2009: Haruhiko Fuwa; Makoto Sasaki
Synthesis of 2-substituted indoles and indolines via Suzuki-Miyaura coupling/5-endo-trig cyclization strategies.
The Journal of organic chemistry 2009;74(1):212-21.
2008: William C Sheets; Evan S Stampler; Mariana I Bertoni; Makoto Sasaki; Tobin J Marks; Thomas O Mason; Kenneth R Poeppelmeier
Silver delafossite oxides.
Inorganic chemistry 2008;47(7):2696-705.
2008: Makoto Sasaki; Haruhiko Fuwa
Convergent strategies for the total synthesis of polycyclic ether marine metabolites.
Natural product reports 2008;25(2):401-26.
2008: Yoshiyuki Takeda; Jinglu Shi; Masato Oikawa; Makoto Sasaki
Assignment of the absolute configuration of goniodomin A by NMR spectroscopy and synthesis of model compounds.
Organic letters 2008;10(5):1013-6.
2008: L Leanne Lash; James M Sanders; Nobuyuki Akiyama; Muneo Shoji; Pekka Postila; Olli Pentikäinen; Makoto Sasaki; Ryuichi Sakai; Geoffrey T Swanson
Novel analogs and stereoisomers of the marine toxin neodysiherbaine with specificity for kainate receptors.
The Journal of pharmacology and experimental therapeutics 2008;324(2):484-96.
2008: Makoto Sasaki; Koichi Tsubone; Kunimori Aoki; Nobuyuki Akiyama; Muneo Shoji; Masato Oikawa; Ryuichi Sakai; Keiko Shimamoto
Rapid and efficient synthesis of dysiherbaine and analogues to explore structure-activity relationships.
The Journal of organic chemistry 2008;73(1):264-73.
2008: Haruhiko Fuwa; Shinya Naito; Tomomi Goto; Makoto Sasaki
Total synthesis of (+)-neopeltolide.
Angewandte Chemie (International ed. in English) 2008;47(25):4737-9.
2007: Haruhiko Fuwa; Makoto Sasaki
Recent advances in the synthesis of marine polycyclic ether natural products.
Current opinion in drug discovery & development 2007;10(6):784-806.
2007: Haruhiko Fuwa; Makoto Sasaki
Strategies for the synthesis of 2-substituted indoles and indolines starting from acyclic alpha-phosphoryloxy enecarbamates.
Organic letters 2007;9(17):3347-50.
2007: Haruhiko Fuwa; Makoto Sasaki
A strategy for the synthesis of 2,3-disubstituted indoles starting from N-(o-halophenyl)allenamides.
Organic & biomolecular chemistry 2007;5(14):2214-8.
2007: Haruhiko Fuwa; Makoto Sasaki
A new method for the generation of indole-2,3-quinodimethanes and 2-(N-alkoxycarbonylamino)-1,3-dienes. Intramolecular Heck/Diels-Alder cycloaddition cascade starting from acyclic alpha-phosphoryloxy [corrected] enecarbamates.
Chemical communications (Cambridge, England) 2007;(27):2876-8.
2007: Haruhiko Fuwa; Makoto Sasaki
An efficient method for the synthesis of enol ethers and enecarbamates. Total syntheses of isoindolobenzazepine alkaloids, lennoxamine and chilenine.
Organic & biomolecular chemistry 2007;5(12):1849-53.
2007: Haruhiko Fuwa; Yasuko Takahashi; Yu Konno; Naoto Watanabe; Hiroyuki Miyashita; Makoto Sasaki; Hideaki Natsugari; Toshiyuki Kan; Tohru Fukuyama; Taisuke Tomita; Takeshi Iwatsubo
Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors.
ACS chemical biology 2007;2(6):408-18.
2006: Haruhiko Fuwa; Makoto Ebine; Andrea J Bourdelais; Daniel G Baden; Makoto Sasaki
Total synthesis, structure revision, and absolute configuration of (-)-brevenal.
Journal of the American Chemical Society 2006;128(51):16989-99.
2006: Makoto Sasaki; Koichi Tsubone; Muneo Shoji; Masato Oikawa; Keiko Shimamoto; Ryuichi Sakai
Design, total synthesis, and biological evaluation of neodysiherbaine A derivative as potential probes.
Bioorganic & medicinal chemistry letters 2006;16(22):5784-7.
2006: Masato Oikawa; Tomoko Uehara; Taizo Iwayama; Makoto Sasaki
Synthetic study of azaspiracid-1: synthesis of the EFGHI-ring fragment.
Organic letters 2006;8(18):3943-6.
2006: Haruhiko Fuwa; Makoto Ebine; Makoto Sasaki
Total synthesis of the proposed structure of brevenal.
Journal of the American Chemical Society 2006;128(30):9648-50.
2006: Yasuko Takahashi; Haruhiko Fuwa; Akane Kaneko; Makoto Sasaki; Satoshi Yokoshima; Hifumi Koizumi; Tohru Takebe; Toshiyuki Kan; Takeshi Iwatsubo; Taisuke Tomita; Hideaki Natsugari; Tohru Fukuyama
Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.
Bioorganic & medicinal chemistry letters 2006;16(14):3813-6.
2006: Muneo Shoji; Nobuyuki Akiyama; Koichi Tsubone; L Leanne Lash; James M Sanders; Geoffrey T Swanson; Ryuichi Sakai; Keiko Shimamoto; Masato Oikawa; Makoto Sasaki
Total synthesis and biological evaluation of neodysiherbaine A and analogues.
The Journal of organic chemistry 2006;71(14):5208-20.
2006: James M Sanders; Olli Pentikäinen; Luca Settimo; Ulla Pentikäinen; Muneo Shoji; Makoto Sasaki; Ryuichi Sakai; Mark S Johnson; Geoffrey T Swanson
Determination of binding site residues responsible for the subunit selectivity of novel marine-derived compounds on kainate receptors.
Molecular pharmacology 2006;69(6):1849-60.
2005: James M Sanders; Koichi Ito; Luca Settimo; Olli Pentikäinen; Muneo Shoji; Makoto Sasaki; Mark S Johnson; Ryuichi Sakai; Geoffrey T Swanson
Divergent pharmacological activity of novel marine-derived excitatory amino acids on glutamate receptors.
The Journal of pharmacology and experimental therapeutics 2005;314(3):1068-78.
2005: Soichiro Matsushima; Kazuya Maeda; Chihiro Kondo; Masaru Hirano; Makoto Sasaki; Hiroshi Suzuki; Yuichi Sugiyama
Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein.
The Journal of pharmacology and experimental therapeutics 2005;314(3):1059-67.
2005: Kazushi Sato; Makoto Sasaki
Studies toward the total synthesis of gambieric acids, potent antifungal polycyclic ethers: convergent synthesis of the CDEFG-ring system.
Organic letters 2005;7(12):2441-4.
2005: Chihiro Tsukano; Makoto Ebine; Makoto Sasaki
Convergent total synthesis of gymnocin-A and evaluation of synthetic analogues.
Journal of the American Chemical Society 2005;127(12):4326-35.
2004: Haruhiko Fuwa; Noriko Kainuma; Kazuo Tachibana; Chihiro Tsukano; Masayuki Satake; Makoto Sasaki
Diverted total synthesis and biological evaluation of gambierol analogues: elucidation of crucial structural elements for potent toxicity.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(19):4894-909.
2004: Makoto Sasaki; Hiroshi Suzuki; Jun Aoki; Kousei Ito; Peter J Meier Abt; Yuichi Sugiyama
Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance associated protein 2.
Molecular pharmacology 2004;66(3):450-9.
2004: Makoto Sasaki; Makoto Ebine; Hiroyuki Takagi; Hiroyuki Takakura; Takeshi Shida; Masayuki Satake; Yasukatsu Oshima; Tomoji Igarashi; Takeshi Yasumoto
Synthesis of the CDE/FG ring models of prymnesins: reassignment of the relative configuration of the E/F ring juncture.
Organic letters 2004;6(9):1501-4.
2003: Chihiro Tsukano; Makoto Sasaki
Total synthesis of gymnocin-A.
Journal of the American Chemical Society 2003;125(47):14294-5.
2003: Haruhiko Fuwa; Noriko Kainuma; Masayuki Satake; Makoto Sasaki
Synthesis and biological evaluation of gambierol analogues.
Bioorganic & medicinal chemistry letters 2003;13(15):2519-22.
2002: Haruhiko Fuwa; Noriko Kainuma; Kazuo Tachibana; Makoto Sasaki
Total synthesis of (-)-gambierol.
Journal of the American Chemical Society 2002;124(50):14983-92.
2002: Haruhiko Fuwa; Makoto Sasaki; Masayuki Satake; Kazuo Tachibana
Total synthesis of gambierol.
Organic letters 2002;4(17):2981-4.
2002: Hiroyuki Takakura; Makoto Sasaki; Shugo Honda; Kazuo Tachibana
Progress toward the total synthesis of ciguatoxins: a convergent synthesis of the FGHIJKLM ring fragment.
Organic letters 2002;4(16):2771-4.
2002: Makoto Sasaki; Tetsuji Noguchi; Kazuo Tachibana
Intramolecular radical cyclization-ring-closing metathesis approach to fused polycyclic ethers. Convergent synthesis and conformational analysis of the (E)FGH ring system of ciguatoxin.
The Journal of organic chemistry 2002;67(10):3301-10.
2002: Makoto Sasaki; Chihiro Tsukano; Kazuo Tachibana
Studies toward the total synthesis of gymnocin A, a cytotoxic polyether: a highly convergent entry to the F-N ring fragment.
Organic letters 2002;4(10):1747-50.
2002: Makoto Sasaki; Hiroshi Suzuki; Kousei Ito; Takaaki Abe; Yuichi Sugiyama
Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2).
The Journal of biological chemistry 2002;277(8):6497-503.
2001: Haruhiko Fuwa; Makoto Sasaki; Kazuo Tachibana
Synthetic studies toward gambierol. Convergent synthesis of the octacyclic polyether core.
Organic letters 2001;3(22):3549-52.
1998: Keiichi Konoki; M Hashimoto; Taro Nonomura; Makoto Sasaki; Masayuki Murata; Kazuo Tachibana
Inhibition of maitotoxin-induced Ca2+ influx in rat glioma C6 cells by brevetoxins and synthetic fragments of maitotoxin.
Journal of neurochemistry 1998;70(1):409-16.