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Shigeki Sasaki

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TOP 3
Taiji Goto; Masashi Hasegawa; Kazuki Hirahara; Tsuyoshi Mikkaichi; Kiyoshi Mizukami; Naoki Nakao; Akiko Shiina; Yoshitaka Sogawa; Osamu Suzuki; Mizuki Takahashi; Tomoko Takahashi; Toshiharu Yoshino; Shigeki Sasaki
Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors.
Hidenori Okamura; Yosuke Taniguchi; Shigeki Sasaki
N-(Guanidinoethyl)-2'-deoxy-5-methylisocytidine exhibits selective recognition of a CG interrupting site for the formation of anti-parallel triplexes.
Yohei Koga; Yosuke Taniguchi; Shigeki Sasaki
Synthesis of the oligoribonucleotides incorporating 8-oxo-guanosine and evaluation of their base pairing properties.

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2013: Taiji Goto; Masashi Hasegawa; Kazuki Hirahara; Tsuyoshi Mikkaichi; Kiyoshi Mizukami; Naoki Nakao; Akiko Shiina; Yoshitaka Sogawa; Osamu Suzuki; Mizuki Takahashi; Tomoko Takahashi; Toshiharu Yoshino; Shigeki Sasaki
Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors.
Bioorganic & medicinal chemistry letters 2013;23(11):3325-8.
2013: Hidenori Okamura; Yosuke Taniguchi; Shigeki Sasaki
N-(Guanidinoethyl)-2'-deoxy-5-methylisocytidine exhibits selective recognition of a CG interrupting site for the formation of anti-parallel triplexes.
Organic & biomolecular chemistry 2013;11(23):3918-24.
2013: Yohei Koga; Yosuke Taniguchi; Shigeki Sasaki
Synthesis of the oligoribonucleotides incorporating 8-oxo-guanosine and evaluation of their base pairing properties.
Nucleosides, nucleotides & nucleic acids 2013;32(3):124-36.
2012: Yosuke Taniguchi; Shigeki Sasaki
An efficient antigene activity and antiproliferative effect by targeting the Bcl-2 or survivin gene with triplex forming oligonucleotides containing a W-shaped nucleoside analogue (WNA-βT).
Organic & biomolecular chemistry 2012;10(41):8336-41.
2012: Yukiko Abe; Osamu Nakagawa; Rie Yamaguchi; Shigeki Sasaki
Synthesis and binding properties of new selective ligands for the nucleobase opposite the AP site.
Bioorganic & medicinal chemistry 2012;20(11):3470-9.
2012: Eriko Aoki; Yosuke Taniguchi; Yasumasa Wada; Shigeki Sasaki
Efficient DNA strand displacement by a W-shaped nucleoside analogue (WNA-βT) containing an ortho-methyl-substituted phenyl ring.
Chembiochem : a European journal of chemical biology 2012;13(8):1152-60.
2012: Kazumitsu Onizuka; Daichi Jitsuzaki; Zhichun Li; Takamasa Nishioka; Yosuke Taniguchi; Shigeki Sasaki
An efficient and simple method for site-selective modification of O6-methyl-2'-deoxyguanosine in DNA.
Chemical communications (Cambridge, England) 2012;48(33):3969-71.
2012: Shigeki Sasaki; Kazumitsu Onizuka; Yosuke Taniguchi
Oligodeoxynucleotide containing s-functionalized 2'-deoxy-6-thioguanosine: facile tools for base-selective and site-specific internal modification of RNA.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2012;Chapter 4():Unit 4.49.1-16.
2012: Tamer Nasr; Hidenori Okamura; Tomoko Takaki; Yosuke Taniguchi; Shigeki Sasaki
Properties of oligonucleotide with phenyl-substituted carbocyclic nucleoside analogs for the formation of duplex and triplex DNA.
Nucleosides, nucleotides & nucleic acids 2012;31(12):841-60.
2011: Shigeki Sasaki; Kazumitsu Onizuka; Yosuke Taniguchi
The oligodeoxynucleotide probes for the site-specific modification of RNA.
Chemical Society reviews 2011;40(12):5698-706.
2011: Yosuke Taniguchi; Ryota Kawaguchi; Shigeki Sasaki
Adenosine-1,3-diazaphenoxazine derivative for selective base pair formation with 8-oxo-2'-deoxyguanosine in DNA.
Journal of the American Chemical Society 2011;133(19):7272-5.
2011: Kazumitsu Onizuka; Atsushi Shibata; Yosuke Taniguchi; Shigeki Sasaki
Pin-point chemical modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide-alkyne cycloaddition reaction.
Chemical communications (Cambridge, England) 2011;47(17):5004-6.
2010: Yosuke Taniguchi; Akiko Nitta; Sun Min Park; Akiko Kohara; Takahiro Uzu; Shigeki Sasaki
The ODN probes conjugating the Cu(II) complex enhance the luminol chemiluminescence by assembling on the DNA template.
Bioorganic & medicinal chemistry 2010;18(24):8614-7.
2010: Issei Doi; Genichiro Tsuji; Kyoko Kawakami; Osamu Nakagawa; Yosuke Taniguchi; Shigeki Sasaki
The spermine-bisaryl conjugate as a potent inducer of B- to Z-DNA transition.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(39):11993-9.
2010: Manabu Nakazono; Ai Jinguji; Shinkoh Nanbu; Ryoichi Kuwano; Zilong Zheng; Kenichiro Saita; Yuji Oshikawa; Yuta Mikuni; Tatsuhiro Murakami; Yi Zhao; Shigeki Sasaki; Kiyoshi Zaitsu
Fluorescence and chemiluminescence properties of indolylmaleimides: experimental and theoretical studies.
Physical chemistry chemical physics : PCCP 2010;12(33):9783-93.
2010: Kazumitsu Onizuka; Yosuke Taniguchi; Shigeki Sasaki
Activation and alteration of base selectivity by metal cations in the functionality-transfer reaction for RNA modification.
Bioconjugate chemistry 2010;21(8):1508-12.
2010: Zhichun Li; Osamu Nakagawa; Yohei Koga; Yosuke Taniguchi; Shigeki Sasaki
Synthesis of new derivatives of 8-oxoG-clamp for better understanding the recognition mode and improvement of selective affinity.
Bioorganic & medicinal chemistry 2010;18(11):3992-8.
2010: Yosuke Taniguchi; Yusuke Kurose; Takamasa Nishioka; Fumi Nagatsugi; Shigeki Sasaki
The alkyl-connected 2-amino-6-vinylpurine (AVP) crosslinking agent for improved selectivity to the cytosine base in RNA.
Bioorganic & medicinal chemistry 2010;18(8):2894-901.
2010: Kazumitsu Onizuka; Yosuke Taniguchi; Shigeki Sasaki
A new usage of functionalized oligodeoxynucleotide probe for site-specific modification of a guanine base within RNA.
Nucleic acids research 2010;38(5):1760-6.
2009: Yosuke Taniguchi; Yuko Uchida; Tomoko Takaki; Eriko Aoki; Shigeki Sasaki
Recognition of CG interrupting site by W-shaped nucleoside analogs (WNA) having the pyrazole ring in an anti-parallel triplex DNA.
Bioorganic & medicinal chemistry 2009;17(19):6803-10.
2009: Kazumitsu Onizuka; Yosuke Taniguchi; Shigeki Sasaki
A new odorless procedure for the synthesis of 2'-deoxy-6-thioguanosine and its incorporation into oligodeoxynucleotides.
Nucleosides, nucleotides & nucleic acids 2009;28(8):752-60.
2009: Kazumitsu Onizuka; Yosuke Taniguchi; Shigeki Sasaki
Site-specific covalent modification of RNA guided by functionality-transfer oligodeoxynucleotides.
Bioconjugate chemistry 2009;20(4):799-803.
2009: Tamer Nasr; Zhichun Li; Osamu Nakagawa; Yosuke Taniguchi; Sayaka Ono; Shigeki Sasaki
Selective fluorescence quenching of the 8-oxoG-clamp by 8-oxodeoxyguanosine in ODN.
Bioorganic & medicinal chemistry letters 2009;19(3):727-30.
2009: Yosuke Taniguchi; Yusuke Kurose; Takamasa Nishioka; Fumi Nagatsugi; Shigeki Sasaki
Evaluation of the antisense effect of PEGylated oligodeoxynucleotides containing intelligent nucleoside analogues.
Nucleic acids symposium series (2004) 2009;(53):167-8.
2009: Kazumitsu Onizuka; Yosuke Taniguchi; Takamasa Nishioka; Shigeki Sasaki
Site-specific modification of RNA by functionality-transfer ODN probes.
Nucleic acids symposium series (2004) 2009;(53):67-8.
2008: Takeshi Fuchigami; Terushi Haradahira; Noriko Fujimoto; Takashi Okauchi; Jun Maeda; Kazutoshi Suzuki; Tetsuya Suhara; Fumihiko Yamamoto; Shigeki Sasaki; Takahiro Mukai; Hiroshi Yamaguchi; Mikako Ogawa; Yasuhiro Magata; Minoru Maeda
Difference in brain distributions of carbon 11-labeled 4-hydroxy-2(1H)-quinolones as PET radioligands for the glycine-binding site of the NMDA ion channel.
Nuclear medicine and biology 2008;35(2):203-12.
2008: Kazumitsu Onizuka; Yosuke Taniguchi; Takamasa Nishioka; Shigeki Sasaki
Site-specific modification by functionality-transfer oligonucleotide with the photo-inducible reactivity.
Nucleic acids symposium series (2004) 2008;(52):367-8.
2008: Yuko Uchida; Yosuke Taniguchi; Eriko Aoki; Mieko Togo; Shigeki Sasaki
Formation of a stable triplex incorporating a CG interrupting site by a new WNA derivative containing 3-aminopyrazole as a nucleobase.
Nucleic acids symposium series (2004) 2008;(52):137-8.
2008: John A Brazier; Ippei Onishi; Shigeki Sasaki
Binding of two bis-bipyridine minor groove binders to a DNA template in the presence of Cu2+ ions.
Nucleic acids symposium series (2004) 2008;(52):107-8.
2008: Yusuke Kurose; Yosuke Taniguchi; Fumi Nagatsugi; Shigeki Sasaki
Synthesis of the new nucleoside analogue connecting 2-amino-6-vinylpurine to the 2'-deoxyribose skeleton via the methylene linker.
Nucleic acids symposium series (2004) 2008;(52):43-4.
2007: Takahiro Uzu; Shigeki Sasaki
A new copper(II) complex as an efficient catalyst of luminol chemiluminescence.
Organic letters 2007;9(21):4383-6.
2007: Mohammed Alam; Alokes Majumdar; Arun Kalliat Thazhathveetil; Su-Ting Liu; Ji-Lan Liu; Nitin Puri; Bernard Cuenoud; Shigeki Sasaki; Paul S Miller; Michael M Seidman
Extensive sugar modification improves triple helix forming oligonucleotide activity in vitro but reduces activity in vivo.
Biochemistry 2007;46(35):10222-33.
2007: Osamu Nakagawa; Sayaka Ono; Akira Tsujimoto; Zhichun Li; Shigeki Sasaki
Selective fluorescence detection of 8-oxoguanosine with 8-oxoG-clamp.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):645-9.
2007: Sayaka Ono; Zhichun Li; Yohei Koga; Akira Tsujimoto; Osamu Nakagawa; Shigeki Sasaki
Development of a specific fluorescent probe for 8-oxoguanosine.
Nucleic acids symposium series (2004) 2007;(51):315-6.
2007: Eriko Aoki; Yosuke Taniguchi; Shigeki Sasaki
Effective strand invasion ODN incorporating a new bicyclic nucleoside analogue (WNA).
Nucleic acids symposium series (2004) 2007;(51):255-6.
2007: Kazumitsu Onizuka; Yosuke Taniguchi; Shigeki Sasaki
Development of novel thioguanosine analogs with the ability to specifically modify cytidine.
Nucleic acids symposium series (2004) 2007;(51):5-6.
2007: Osamu Nakagawa; Sayaka Ono; Zhichun Li; Akira Tsujimoto; Shigeki Sasaki
Specific fluorescent probe for 8-oxoguanosine.
Angewandte Chemie (International ed. in English) 2007;46(24):4500-3.
2007: Saori Tsujita; Mikimasa Tanada; Tomonobu Kataoka; Shigeki Sasaki
Equilibrium shift by target DNA substrates for determination of DNA binding ligands.
Bioorganic & medicinal chemistry letters 2007;17(1):68-72.
2006: Shigeki Sasaki; Fumi Nagatsugi
Application of unnatural oligonucleotides to chemical modification of gene expression.
Current opinion in chemical biology 2006;10(6):615-21.
2006: Mikimasa Tanada; Saori Tsujita; Tomonobu Kataoka; Shigeki Sasaki
Cu2+ -mediated assembly of the minor groove binders on the DNA template with sequence selectivity.
Organic letters 2006;8(12):2475-8.
2006: Md Monsur Ali; Motoi Oishi; Fumi Nagatsugi; Kenya Mori; Yukio Nagasaki; Kazunori Kataoka; Shigeki Sasaki
Intracellular inducible alkylation system that exhibits antisense effects with greater potency and selectivity than the natural oligonucleotide.
Angewandte Chemie (International ed. in English) 2006;45(19):3136-40.
2006: Yosuke Taniguchi; Ayako Nakamura; Yusuke Senko; Fumi Nagatsugi; Shigeki Sasaki
Effects of halogenated WNA derivatives on sequence dependency for expansion of recognition sequences in non-natural-type triplexes.
The Journal of organic chemistry 2006;71(5):2115-22.
2006: Mikimasa Tanada; Saori Tsujita; Shigeki Sasaki
Design of new bidentate ligands constructed of two Hoechst 33258 units for discrimination of the length of two A3T3 binding motifs.
The Journal of organic chemistry 2006;71(1):125-34.
2006: Eriko Aoki; Yosuke Taniguchi; Mieko Togo; Shigeki Sasaki
Effects of the modified aromatic ring of WNA on stability of triplex DNA.
Nucleic acids symposium series (2004) 2006;(50):185-6.
2006: Tomonobu Kataoka; Mikimasa Tanada; Ippei Onishi; Shigeki Sasaki
Recognition of DNA with assembly of minor groove binders mediated by metal complexation.
Nucleic acids symposium series (2004) 2006;(50):161-2.
2006: Osamu Nakagawa; Sayaka Ono; Akira Tsujimoto; Zhichun Li; Shigeki Sasaki
Fluorescence detection of 8-oxoguanosine by G-clamp derivatives.
Nucleic acids symposium series (2004) 2006;(50):21-2.
2006: Md Monsur Ali; Fumi Nagatsugi; Shigeki Sasaki; Ryusuke Nakahara; Minoru Maeda
Application of 2-amino-6-vinylpurine as an efficient agent for conjugation of oligonucleotides.
Nucleosides, nucleotides & nucleic acids 2006;25(2):159-69.
2005: Takeshi Kawasaki; Fumi Nagatsugi; Md Monsur Ali; Minoru Maeda; Kumiko Sugiyama; Kenji Hori; Shigeki Sasaki
Hybridization-promoted and cytidine-selective activation for cross-linking with the use of 2-amino-6-vinylpurine derivatives.
The Journal of organic chemistry 2005;70(1):14-23.
2005: Fumi Nagatsugi; Sayaka Mori; Md Monsur Ali; Yuki Ogata; Shigeki Sasaki
Substituent effects on the in situ activation of the double activated cross-linking reaction.
Nucleic acids symposium series (2004) 2005;(49):175-6.
2005: Yosuke Taniguchi; Ayako Nakamura; Eriko Aoki; Shigeki Sasaki
Modification of the aromatic ring of the WNA analogues for expansion of the triplex recognition codes.
Nucleic acids symposium series (2004) 2005;(49):173-4.
2005: Mikimasa Tanada; Shigeki Sasaki
Discrimination of the length of two remote binding sites by the spacer-linked DNA minor groove binders.
Nucleic acids symposium series (2004) 2005;(49):1-2.
2005: Yosuke Taniguchi; Ayako Nakamura; Yusuke Senko; Keiichi Kodama; Fumi Nagatsugi; Shigeki Sasaki
Expansion of triplex recognition codes by the use of novel bicyclic nucleoside derivatives (WNA).
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):823-7.
2005: Md Monsur Ali; Fumi Nagatsugi; Shizuka Nakayama; Mohammed Alam; Takeshi Kawasaki; Shigeki Sasaki
Design of highly efficient and selective transfer reaction of nitrosyl group to dc and d(M)C resulting in specific deamination.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):721-4.
2004: Shuhei Imoto; Yoshinari Haruta; Kyouichi Watanabe; Shigeki Sasaki
New DNA binding ligands as a model of chromomycin A3.
Bioorganic & medicinal chemistry letters 2004;14(19):4855-9.
2004: Md Monsur Ali; Mohammed Alam; Takeshi Kawasaki; Shizuka Nakayama; Fumi Nagatsugi; Shigeki Sasaki
Sequence- and base-specific delivery of nitric oxide to cytidine and 5-methylcytidine leading to efficient deamination.
Journal of the American Chemical Society 2004;126(29):8864-5.
2004: Shigeki Sasaki; Fumie Kurosaki; Terushi Haradahira; Fumihiko Yamamoto; Jun Maeda; Takashi Okauchi; Kazutoshi Suzuki; Tetsuya Suhara; Minoru Maeda
Synthesis of 11C-labelled bis(phenylalkyl)amines and their in vitro and in vivo binding properties in rodent and monkey brains.
Biological & pharmaceutical bulletin 2004;27(4):531-7.
2004: Fumi Nagatsugi; Shigeki Sasaki
Chemical tools for targeted mutagenesis of DNA based on triple helix formation.
Biological & pharmaceutical bulletin 2004;27(4):463-7.
2004: Shigeki Sasaki; Yosuke Taniguchi; Ryo Takahashi; Yusuke Senko; Keiichi Kodama; Fumi Nagatsugi; Minoru Maeda
Selective formation of stable triplexes including a TA or a CG interrupting site with new bicyclic nucleoside analogues (WNA).
Journal of the American Chemical Society 2004;126(2):516-28.
2004: Yosuke Taniguchi; Ayako Nakamura; Yusuke Senko; Shigeki Sasaki
Effects of 5-substituted pyrimidine nucleoside bases of WNA on stability of triplex DNA.
Nucleic acids symposium series (2004) 2004;(48):69-70.
2004: Ali Md Monsur; Fumi Nagatsugi; Motoi Oishi; Yukio Nagasaki; Kazunari Kataoka; Shigeki Sasaki
Synthesis and evaluation of the functional oligonucleotides-PEG conjugates.
Nucleic acids symposium series (2004) 2004;(48):61-2.
2004: Fumi Nagatsugi; Shizuka Nakayama; Md Monsur Ali; Shigeki Sasaki
Selective nitrosyl group transfer reaction to cytidine using oligonucleotides bearing S-nitrosothioguanosine.
Nucleic acids symposium series (2004) 2004;(48):23-4.
2003: Takeshi Fuchigami; Terushi Haradahira; Takuya Arai; Takashi Okauchi; Jun Maeda; Kazutoshi Suzuki; Fumihiko Yamamoto; Tetsuya Suhara; Shigeki Sasaki; Minoru Maeda
Synthesis and brain regional distribution of [11C]NPS 1506 in mice and rat: an N-methyl-D-aspartate (NMDA) receptor antagonist.
Biological & pharmaceutical bulletin 2003;26(11):1570-3.
2003: Fumi Nagatsugi; Shigeki Sasaki; Paul S Miller; Michael M Seidman
Site-specific mutagenesis by triple helix-forming oligonucleotides containing a reactive nucleoside analog.
Nucleic acids research 2003;31(6):e31.
2003: Fumi Nagatsugi; Yasushi Suenaga; Shigeki Sasaki
Efficient cross-linking reactions by functional nucleobases capable of in situ activation under neutral conditions.
Nucleic acids research. Supplement (2001) 2003;(3):155-6.
2003: Yosuke Taniguchi; Yusuke Senko; Kelichi Kodama; Ayako Nakamura; Shigeki Sasaki
Design and evaluation of novel nucleoside analogs (WNA) for specific formation of non-natural type triplexes containing a TA or CG interrupting site.
Nucleic acids research. Supplement (2001) 2003;(3):113-4.
2002: Shigeki Sasaki
[Creation of functional recognition molecules for chemical modification of gene expression].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2002;122(12):1081-93.
2002: Fumihiko Yamamoto; Mizuho Aoki; Yoshiya Furusawa; Koichi Ando; Yasuo Kuwabara; Kouji Masuda; Shigeki Sasaki; Minoru Maeda
Synthesis and evaluation of 4-bromo-1-(3-[18F]fluoropropyl)-2-nitroimidazole with a low energy LUMO orbital designed as brain hypoxia-targeting imaging agent.
Biological & pharmaceutical bulletin 2002;25(5):616-21.
2002: Fumi Nagatsugi; Yoshihisa Matsuyama; Minoru Maeda; Shigeki Sasaki
Selective cross-linking to the adenine of the TA interrupting site within the triple helix.
Bioorganic & medicinal chemistry letters 2002;12(3):487-9.
2002: Md Monsur Ali; Fumi Nagatsugi; Fumihiko Yamamoto; Minoru Maeda; Shigeki Sasaki
2-Amino-6-vinyl purine as a tool for post synthetic conjugation of DNA with radio-, spin-, fluorescence labels and peptides.
Nucleic acids research. Supplement (2001) 2002;(2):149-50.
2002: Yosuke Taniguchi; Ryo Takahashi; Keiichi Kodama; Yusuke Senko; Minoru Maeda; Shigeki Sasaki
Selective formation of non-natural type triplexes containing TA interrupting sites with the TFO incorporating W-shape nucleic acid (WNA) analogs.
Nucleic acids research. Supplement (2001) 2002;(2):35-6.
2002: Fumi Nagatsugi; Shigeki Sasaki; Michael M Seidmen; Paul S Miller
Mutagenesis targeted by triple-helix forming oligonucleotides containing a reactive nucleoside analogue.
Nucleic acids research. Supplement (2001) 2002;(2):31-2.
2001: Shigeki Sasaki; T Ehara; Mohammed Alam; Y Fujino; N Harada; J Kimura; H Nakamura; Minoru Maeda
Solid-Phase synthesis of a library constructed of aromatic phosphate, long alkyl chains and tryptophane components, and identification of potent dipeptide telomerase inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(19):2581-4.
2001: Fumi Nagatsugi; N Tokuda; Minoru Maeda; Shigeki Sasaki
A new reactive nucleoside analogue for highly reactive and selective cross-linking reaction to cytidine under neutral conditions.
Bioorganic & medicinal chemistry letters 2001;11(19):2577-9.
2001: Fumi Nagatsugi; Takeshi Kawasaki; N Tokuda; Minoru Maeda; Shigeki Sasaki
Site-directed alkylation to cytidine within duplex by the oligonucleotides containing functional nucleobases.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):915-9.
2001: Shigeki Sasaki; T Shibata; H Torigoe; Y Shibata; Minoru Maeda
Novel class of DNA binding motifs based on bistetrahydrofuran and bisfuran skeleton with long alkyl chains.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):551-8.
2001: Shigeki Sasaki
Active oligonucleotides incorporating alkylating an agent as potential sequence- and base selective modifier of gene expression.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;13(1):43-51.
2001: Shigeki Sasaki; T Ehara; I Sakata; Y Fujino; N Harada; J Kimura; H Nakamura; Minoru Maeda
Development of novel telomerase inhibitors based on a bisindole unit.
Bioorganic & medicinal chemistry letters 2001;11(4):583-5.
2001: Shigeki Sasaki; T Kanda; N Ishibashi; Fumihiko Yamamoto; Terushi Haradahira; Takashi Okauchi; J Meda; K Suzuki; Minoru Maeda
4,5,9,10-Tetrahydro-1,4-ethanobenz[b]quinolizine as a prodrug for its quinolizinium cation as a ligand to the open state of the TCP-binding site of NMDA receptors.
Bioorganic & medicinal chemistry letters 2001;11(4):519-21.
2001: Fumi Nagatsugi; D Usui; Takeshi Kawasaki; Minoru Maeda; Shigeki Sasaki
Selective reaction to a flipping cytidine of the duplex DNA mediated by triple helix formation.
Bioorganic & medicinal chemistry letters 2001;11(3):343-5.
2001: Fumi Nagatsugi; N Tokuda; Takeshi Kawasaki; Minoru Maeda; Shigeki Sasaki
Efficient cross-linking to cytidine under neutral conditions using the 2-amino-6-vinylpurine derivative having an additional activating group.
Nucleic acids research. Supplement (2001) 2001;(1):87-8.
2001: Shigeki Sasaki; H Yamauchi; R Takahasi; Yosuke Taniguchi; Minoru Maeda
New base analogs for the formation of non-natural triplexes.
Nucleic acids research. Supplement (2001) 2001;(1):23-4.
2000: Mohammed Alam; Minoru Maeda; Shigeki Sasaki
DNA-binding peptides searched from the solid-phase combinatorial library with the use of the magnetic beads attaching the target duplex DNA.
Bioorganic & medicinal chemistry 2000;8(2):465-73.
2000: Takeshi Kawasaki; Fumi Nagatsugi; Minoru Maeda; Shigeki Sasaki
Efficient cross-linking to cytidine using substituted phenylsulfide derivatives of 2-amino-6-vinylpurine nucleoside via synchronous activation within duplex.
Nucleic acids symposium series 2000;(44):129-30.
2000: Fumi Nagatsugi; D Usui; Takeshi Kawasaki; Minoru Maeda; Shigeki Sasaki
Design and synthesis of the novel cross-linking reagents triggered by the triple helix formation.
Nucleic acids symposium series 2000;(44):39-40.
1999: T Shibata; H Torigoe; Y Shibata; Minoru Maeda; Shigeki Sasaki
Novel DNA-binding ligands with sequence selectivity based on hydrophobic structure.
Nucleic acids symposium series 1999;(42):251-2.
1999: Mohammed Alam; Minoru Maeda; Shigeki Sasaki
DNA binding affinity of pentapeptides selected from combinatorial library.
Nucleic acids symposium series 1999;(42):173-4.
1999: Takeshi Kawasaki; Fumi Nagatsugi; D Usui; Minoru Maeda; Shigeki Sasaki
Efficient cross-linking to cytidine by functional nucleobases capable of in situ activation.
Nucleic acids symposium series 1999;(42):43-4.
1998: Shigeki Sasaki; N Ishibashi; T Kuwamura; H Sano; M Matoba; T Nisikawa; Minoru Maeda
Excellent acceleration of the Diels-Alder reaction by microwave irradiation for the synthesis of new fluorine-substituted ligands of NMDA receptor.
Bioorganic & medicinal chemistry letters 1998;8(21):2983-6.
1998: Shigeki Sasaki; T Hashimoto; N Obana; H Yasuda; Y Uehara; Minoru Maeda
Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure.
Bioorganic & medicinal chemistry letters 1998;8(9):1019-22.
1998: Shigeki Sasaki; K Maruta; H Naito; R Maemura; E Kawahara; Minoru Maeda
In vitro antitumor activities of new synthetic bistetrahydrofuran derivatives as analogs of Annonaceous acetogenins.
Chemical & pharmaceutical bulletin 1998;46(1):154-8.
1997: Fumi Nagatsugi; Takeshi Kawasaki; Minoru Maeda; Shigeki Sasaki
Novel cross-linking reaction of oligonucleotides incorporating new base analogs with selective reactivity toward cytidine.
Nucleic acids symposium series 1997;(37):67-8.
1997: S Nakashima; N Matsuura; Fumi Nagatsugi; Minoru Maeda; Shigeki Sasaki
Synthesis and evaluation of oligonucleotides incorporating novel artificial nucleobases for the selective formation of non-natural type triplexes.
Nucleic acids symposium series 1997;(37):33-4.
1995: Fumi Nagatsugi; F Inoue; Shigeki Sasaki; Minoru Maeda
18F-labeled octanoates as potential agents for cerebral fatty acid studies. The influence of 4-substitution and the fluorine position on biodistribution.
Chemical & pharmaceutical bulletin 1995;43(4):607-15.
1995: Fumi Nagatsugi; K Uemura; S Nakashima; Minoru Maeda; Shigeki Sasaki
Design and synthesis of new cross-linking agents.
Nucleic acids symposium series 1995;(34):171-2.
1994: Fumi Nagatsugi; Shigeki Sasaki; Minoru Maeda
8-[18F]fluorooctanoic acid and its beta-substituted derivatives as potential agents for cerebral fatty acid studies: synthesis and biodistribution.
Nuclear medicine and biology 1994;21(6):809-17.
1993: K Orita; Shigeki Sasaki; Minoru Maeda; A Hashimoto; T Nishikawa; T Yugami; K Umezu
Synthesis and evaluation of 1-(1-[5-(2'-[18F]fluoroethyl)-2-thienyl]-cyclohexyl)piperidine as a potential in vivo radioligand for the NMDA receptor-channel complex.
Nuclear medicine and biology 1993;20(7):865-73.
1993: Shigeki Sasaki; F Takao; K Watanabe; N Obana; Minoru Maeda; T Fukumura; S Takehara
New fluorinated dopamine D2 ligands with benzofuran skeleton. The synthesis and in vitro evaluation.
Chemical & pharmaceutical bulletin 1993;41(2):296-300.
1992: Minoru Maeda; Shigeki Sasaki; T Fukumura; E Fukuzawa; K Watanabe; M Kojima; T Tahara; K Masuda; Y Ichiya
Positron-emitting N-[18F]fluoroalkyl and [18F]fluoropyrrolidinyl analogues of eticlopride as potential in vivo radioligands for dopamine D2 receptors.
Chemical & pharmaceutical bulletin 1992;40(7):1793-8.
1992: F Yamamoto; Shigeki Sasaki; Minoru Maeda
Positron labeled antioxidants: synthesis and tissue biodistribution of 6-deoxy-6-[18F]fluoro-L-ascorbic acid.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1992;43(5):633-9.
1991: K Watanabe; T Fukumura; Shigeki Sasaki; Minoru Maeda; S Takehara
New fluorine-substituted analogue of eticlopride with high affinity toward dopamine D2 receptors.
Chemical & pharmaceutical bulletin 1991;39(12):3211-4.