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Takuya Sasaki

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
76
Takai, Yoshimi
12
Kikuchi, Akira
11
Nakanishi, Hiroyuki
11
Takahashi, Kiyohisa
9
Orita, S
8
Takaishi, K
8
Kuroda, Shun'ichi
7
Mammoto, A
7
Nagano, Fumiko
6
Imamura, H
6
Sakaguchi, Gaku
5
Maeda, M
4
Naito, A
4
Igarashi, H
4
Araki, S

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Publications

TOP 3
Nakahara Hirokazu; Otani Tomohiro; Sasaki Takuya; Miura Yasuhiro; Takai Yoshimi; Kogo Mikihiko
Involvement of Cdc42 and Rac small G proteins in invadopodia formation of RPMI7951 cells.
Nagano Fumiko; Kawabe Hiroshi; Nakanishi Hiroyuki; Shinohara Masahiko; Deguchi-Tawarada Maki; Takeuchi Masakazu; Sasaki Takuya; Takai Yoshimi
Rabconnectin-3, a novel protein that binds both GDP/GTP exchange protein and GTPase-activating protein for Rab3 small G protein family.
Nakanishi Hiroyuki; Sasaki Takuya; Takai Yoshimi
Isolation of regulatory proteins for the Rab3 subfamily GTPases.

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All Publications

2003: Nakahara Hirokazu; Otani Tomohiro; Sasaki Takuya; Miura Yasuhiro; Takai Yoshimi; Kogo Mikihiko
Involvement of Cdc42 and Rac small G proteins in invadopodia formation of RPMI7951 cells.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(12):1019-27.
2002: Nagano Fumiko; Kawabe Hiroshi; Nakanishi Hiroyuki; Shinohara Masahiko; Deguchi-Tawarada Maki; Takeuchi Masakazu; Sasaki Takuya; Takai Yoshimi
Rabconnectin-3, a novel protein that binds both GDP/GTP exchange protein and GTPase-activating protein for Rab3 small G protein family.
The Journal of biological chemistry 2002;277(12):9629-32.
2002: Nakanishi Hiroyuki; Sasaki Takuya; Takai Yoshimi
Isolation of regulatory proteins for the Rab3 subfamily GTPases.
Methods in molecular biology (Clifton, N.J.) 2002;189():143-56.
2001: Takai Y; Sasaki T; Matozaki T
Small GTP-binding proteins.
Physiological reviews 2001;81(1):153-208.
2001: Nagano F; Sasaki T; Takai Y
Purification and properties of Rab3 GTPase-activating protein.
Methods in enzymology 2001;329():67-75.
2000: Mammoto A; Sasaki T; Kim Y; Takai Y
Physical and functional interaction of rabphilin-11 with mammalian Sec13 protein. Implication in vesicle trafficking.
The Journal of biological chemistry 2000;275(18):13167-70.
2000: Mammoto A; Takahashi K; Sasaki T; Takai Y
Stimulation of Rho GDI release by ERM proteins.
Methods in enzymology 2000;325():91-101.
1999: Sakaguchi G; Manabe T; Kobayashi K; Orita S; Sasaki T; Naito A; Maeda M; Igarashi H; Katsuura G; Nishioka H; Mizoguchi A; Itohara S; Takahashi T; Takai Y
Doc2alpha is an activity-dependent modulator of excitatory synaptic transmission.
The European journal of neuroscience 1999;11(12):4262-8.
1999: Asakura T; Nakanishi H; Sakisaka T; Takahashi K; Mandai K; Nishimura M; Sasaki T; Takai Y
Similar and differential behaviour between the nectin-afadin-ponsin and cadherin-catenin systems during the formation and disruption of the polarized junctional alignment in epithelial cells.
Genes to cells : devoted to molecular & cellular mechanisms 1999;4(10):573-81.
1999: Mammoto A; Ohtsuka T; Hotta I; Sasaki T; Takai Y
Rab11BP/Rabphilin-11, a downstream target of rab11 small G protein implicated in vesicle recycling.
The Journal of biological chemistry 1999;274(36):25517-24.
1998: Oishi H; Sasaki T; Nagano F; Ikeda W; Ohya T; Wada M; Ide N; Nakanishi H; Takai Y
Localization of the Rab3 small G protein regulators in nerve terminals and their involvement in Ca2+-dependent exocytosis.
The Journal of biological chemistry 1998;273(51):34580-5.
1998: Nagano F; Orita S; Sasaki T; Naito A; Sakaguchi G; Maeda M; Watanabe T; Kominami E; Uchiyama Y; Takai Y
Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport.
The Journal of biological chemistry 1998;273(46):30065-8.
1998: Nagano F; Sasaki T; Fukui K; Asakura T; Imazumi K; Takai Y
Molecular cloning and characterization of the noncatalytic subunit of the Rab3 subfamily-specific GTPase-activating protein.
The Journal of biological chemistry 1998;273(38):24781-5.
1998: Imamura H; Takaishi K; Nakano K; Kodama A; Oishi H; Shiozaki H; Monden M; Sasaki T; Takai Y
Rho and Rab small G proteins coordinately reorganize stress fibers and focal adhesions in MDCK cells.
Molecular biology of the cell 1998;9(9):2561-75.
1998: Sakaguchi G; Orita S; Naito A; Maeda M; Igarashi H; Sasaki T; Takai Y
A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13.
Biochemical and biophysical research communications 1998;248(3):846-51.
1998: Takahashi K; Sasaki T; Mammoto A; Hotta I; Takaishi K; Imamura H; Nakano K; Kodama A; Takai Y
Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl.
Oncogene 1998;16(25):3279-84.
1998: Umikawa M; Tanaka K; Kamei T; Shimizu K; Imamura H; Sasaki T; Takai Y
Interaction of Rho1p target Bni1p with F-actin-binding elongation factor 1alpha: implication in Rho1p-regulated reorganization of the actin cytoskeleton in Saccharomyces cerevisiae.
Oncogene 1998;16(15):2011-6.
1998: Sasaki T; Takai Y
The Rho small G protein family-Rho GDI system as a temporal and spatial determinant for cytoskeletal control.
Biochemical and biophysical research communications 1998;245(3):641-5.
1998: Mammoto A; Sasaki T; Asakura T; Hotta I; Imamura H; Takahashi K; Matsuura Y; Shirao T; Takai Y
Interactions of drebrin and gephyrin with profilin.
Biochemical and biophysical research communications 1998;243(1):86-9.
1998: Asakura T; Sasaki T; Nagano F; Satoh A; Obaishi H; Nishioka H; Imamura H; Hotta K; Tanaka K; Nakanishi H; Takai Y
Isolation and characterization of a novel actin filament-binding protein from Saccharomyces cerevisiae.
Oncogene 1998;16(1):121-30.
1998: Ohya T; Sasaki T; Kato M; Takai Y
Involvement of Rabphilin3 in endocytosis through interaction with Rabaptin5.
The Journal of biological chemistry 1998;273(1):613-7.
1997: Takaishi K; Sasaki T; Kotani H; Nishioka H; Takai Y
Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells.
The Journal of cell biology 1997;139(4):1047-59.
1997: Takahashi K; Sasaki T; Mammoto A; Takaishi K; Kameyama T; Tsukita S; Takai Y
Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein.
The Journal of biological chemistry 1997;272(37):23371-5.
1997: Orita S; Naito A; Sakaguchi G; Maeda M; Igarashi H; Sasaki T; Takai Y
Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery.
The Journal of biological chemistry 1997;272(26):16081-4.
1997: Imamura H; Tanaka K; Hihara T; Umikawa M; Kamei T; Takahashi K; Sasaki T; Takai Y
Bni1p and Bnr1p: downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae.
The EMBO journal 1997;16(10):2745-55.
1997: Kotani H; Takaishi K; Sasaki T; Takai Y
Rho regulates association of both the ERM family and vinculin with the plasma membrane in MDCK cells.
Oncogene 1997;14(14):1705-13.
1997: Naito A; Orita S; Wanaka A; Sasaki T; Sakaguchi G; Maeda M; Igarashi H; Tohyama M; Takai Y
Molecular cloning of mouse Doc2alpha and distribution of its mRNA in adult mouse brain.
Brain research. Molecular brain research 1997;44(2):198-204.
1997: Fukui K; Sasaki T; Imazumi K; Matsuura Y; Nakanishi H; Takai Y
Isolation and characterization of a GTPase activating protein specific for the Rab3 subfamily of small G proteins.
The Journal of biological chemistry 1997;272(8):4655-8.
1997: Sasaki T; Shirataki H; Nakanishi H; Takai Y
Rab3A-rabphilin-3A system in neurotransmitter release.
Advances in second messenger and phosphoprotein research 1997;31():279-94.
1996: Masumoto N; Sasaki T; Tahara M; Mammoto A; Ikebuchi Y; Tasaka K; Tokunaga M; Takai Y; Miyake A
Involvement of Rabphilin-3A in cortical granule exocytosis in mouse eggs.
The Journal of cell biology 1996;135(6 Pt 2):1741-7.
1996: Kato M; Sasaki T; Ohya T; Nakanishi H; Nishioka H; Imamura M; Takai Y
Physical and functional interaction of rabphilin-3A with alpha-actinin.
The Journal of biological chemistry 1996;271(50):31775-8.
1996: Komuro R; Sasaki T; Takaishi K; Orita S; Takai Y
Involvement of Rho and Rac small G proteins and Rho GDI in Ca2+-dependent exocytosis from PC12 cells.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(10):943-51.
1996: Takai Y; Sasaki T; Shirataki H; Nakanishi H
Rab3A small GTP-binding protein in Ca(2+)-dependent exocytosis.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(7):615-32.
1996: Taniguchi T; Takaishi K; Murayama T; Ito M; Iwata N; Chihara K; Sasaki T; Takai Y; Matsui T
Cholecystokinin-B/gastrin receptors mediate rapid formation of actin stress fibers.
Oncogene 1996;12(6):1357-60.
1996: Fujita Y; Sasaki T; Fukui K; Kotani H; Kimura T; Hata Y; Südhof T C; Scheller R H; Takai Y
Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin.
The Journal of biological chemistry 1996;271(13):7265-8.
1996: Orita S; Sasaki T; Komuro R; Sakaguchi G; Maeda M; Igarashi H; Takai Y
Doc2 enhances Ca2+-dependent exocytosis from PC12 cells.
The Journal of biological chemistry 1996;271(13):7257-60.
1996: Matsuda S; Nakanishi H; Sasaki T; Takai Y
A membrane-associated GDP/GTP exchange protein specific for Rho small GTP-binding protein - partial purification and characterization from rat brain.
Oncogene 1996;12(4):915-20.
1996: Komuro R; Sasaki T; Orita S; Maeda M; Takai Y
Involvement of rabphilin-3A in Ca2+-dependent exocytosis from PC12 cells.
Biochemical and biophysical research communications 1996;219(2):435-40.
1995: Takahashi K; Sasaki T; Takai Y
Heterotetramer formation of prenylated Rab3A with two Rabphilin-3A molecules.
Biochemical and biophysical research communications 1995;217(3):979-86.
1995: Takaishi K; Sasaki T; Kameyama T; Tsukita S; Tsukita S; Takai Y
Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows.
Oncogene 1995;11(1):39-48.
1995: Araki K; Nakanishi H; Hirano H; Kato M; Sasaki T; Takai Y
Purification and characterization of Rab GDI beta from rat brain.
Biochemical and biophysical research communications 1995;211(1):296-305.
1995: Orita S; Sasaki T; Naito A; Komuro R; Ohtsuka T; Maeda M; Suzuki H; Igarashi H; Takai Y
Doc2: a novel brain protein having two repeated C2-like domains.
Biochemical and biophysical research communications 1995;206(2):439-48.
1995: Sasaki T; Takai Y
Purification and properties of bovine Rab-GDP dissociation inhibitor.
Methods in enzymology 1995;257():70-9.
1995: Takai Y; Kaibuchi K; Kikuchi A; Sasaki T
Effects of prenyl modifications on interactions of small G proteins with regulators.
Methods in enzymology 1995;250():122-33.
1995: Tanaka K; Sasaki T; Takai Y
Purification and properties of recombinant Rho-GDP dissociation inhibitor.
Methods in enzymology 1995;256():41-9.
1995: Takaishi K; Sasaki T; Takai Y
Cell motility assay and inhibition by Rho-GDP dissociation inhibitor.
Methods in enzymology 1995;256():336-47.
1994: Kato M; Sasaki T; Imazumi K; Takahashi K; Araki K; Shirataki H; Matsuura Y; Ishida A; Fujisawa H; Takai Y
Phosphorylation of Rabphilin-3A by calmodulin-dependent protein kinase II.
Biochemical and biophysical research communications 1994;205(3):1776-84.
1994: Imazumi K; Sasaki T; Takahashi K; Takai Y
Identification of a rabphilin-3A-interacting protein as GTP cyclohydrolase I in PC12 cells.
Biochemical and biophysical research communications 1994;205(2):1409-16.
1994: Fujita Y; Sasaki T; Araki K; Takahashi K; Imazumi K; Kato M; Matsuura Y; Takai Y
GDP/GTP exchange reaction-stimulating activity of Rabphilin-3A for Rab3A small GTP-binding protein.
FEBS letters 1994;353(1):67-70.
1994: Miyazaki A; Sasaki T; Araki K; Ueno N; Imazumi K; Nagano F; Takahashi K; Takai Y
Comparison of kinetic properties between MSS4 and Rab3A GRF GDP/GTP exchange proteins.
FEBS letters 1994;350(2-3):333-6.
1994: Mizoguchi A; Yano Y; Hamaguchi H; Yanagida H; Ide C; Zahraoui A; Shirataki H; Sasaki T; Takai Y
Localization of Rabphilin-3A on the synaptic vesicle.
Biochemical and biophysical research communications 1994;202(3):1235-43.
1994: Nishiyama T; Sasaki T; Takaishi K; Kato M; Yaku H; Araki K; Matsuura Y; Takai Y
rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.
Molecular and cellular biology 1994;14(4):2447-56.
1994: Kobayashi M; Okamoto T; Hayashi K; Yokoyama N; Sasaki T; Kitagawa I
Marine natural products. XXXII. Absolute configurations of C-4 of the manoalide family, biologically active sesterterpenes from the marine sponge Hyrtios erecta.
Chemical & pharmaceutical bulletin 1994;42(2):265-70.
1994: Takaishi K; Sasaki T; Kato M; Yamochi W; Kuroda S; Nakamura T; Takeichi M; Takai Y
Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility.
Oncogene 1994;9(1):273-9.
1994: Yaku H; Sasaki T; Takai Y
The Dbl oncogene product as a GDP/GTP exchange protein for the Rho family: its properties in comparison with those of Smg GDS.
Biochemical and biophysical research communications 1994;198(2):811-7.
1994: Kobayashi M; Kawazoe K; Okamoto T; Sasaki T; Kitagawa I
Marine natural products. XXXI. Structure-activity correlation of a potent cytotoxic dimeric macrolide swinholide A, from the Okinawan marine sponge Theonella swinhoei, and its isomers.
Chemical & pharmaceutical bulletin 1994;42(1):19-26.
1994: Takai Y; Kaibuchi K; Sasaki T; Tanaka K; Shirataki H; Nakanishi H
Rho small G protein and cytoskeletal control.
Princess Takamatsu symposia 1994;24():338-50.
1994: Takai Y; Kaibuchi K; Kikuchi A; Sasaki T; Shirataki H; Tanaka K
Function and mode of action of small G protein.
Progress in clinical and biological research 1994;390():99-113.
1993: Sasaki T; Kato M; Takai Y
Consequences of weak interaction of rho GDI with the GTP-bound forms of rho p21 and rac p21.
The Journal of biological chemistry 1993;268(32):23959-63.
1993: Garrett M D; Kabcenell A K; Zahner J E; Kaibuchi K; Sasaki T; Takai Y; Cheney C M; Novick P J
Interaction of Sec4 with GDI proteins from bovine brain, Drosophila melanogaster and Saccharomyces cerevisiae. Conservation of GDI membrane dissociation activity.
FEBS letters 1993;331(3):233-8.
1993: Kishida S; Shirataki H; Sasaki T; Kato M; Kaibuchi K; Takai Y
Rab3A GTPase-activating protein-inhibiting activity of Rabphilin-3A, a putative Rab3A target protein.
The Journal of biological chemistry 1993;268(30):22259-61.
1993: Sasaki T; Kato M; Nishiyama T; Takai Y
The nucleotide exchange rates of rho and rac small GTP-binding proteins are enhanced to different extents by their regulatory protein Smg GDS.
Biochemical and biophysical research communications 1993;194(3):1188-93.
1993: Kobayashi M; Aoki S; Sakai H; Kihara N; Sasaki T; Kitagawa I
Altohyrtins B and C and 5-desacetylaltohyrtin A, potent cytotoxic macrolide congeners of altohyrtin A, from the Okinawan marine sponge Hyrtios altum.
Chemical & pharmaceutical bulletin 1993;41(5):989-91.
1993: Kishi K; Sasaki T; Kuroda S; Itoh T; Takai Y
Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI).
The Journal of cell biology 1993;120(5):1187-95.
1993: Takaishi K; Kikuchi A; Kuroda S; Kotani K; Sasaki T; Takai Y
Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility.
Molecular and cellular biology 1993;13(1):72-9.
1993: Miura Y; Kikuchi A; Musha T; Kuroda S; Yaku H; Sasaki T; Takai Y
Regulation of morphology by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in Swiss 3T3 cells.
The Journal of biological chemistry 1993;268(1):510-5.
1993: Takai Y; Kaibuchi K; Kikuchi A; Sasaki T; Shirataki H
Regulators of small GTPases.
Ciba Foundation symposium 1993;176():128-38; discussion 138-46.
1992: Ando S; Kaibuchi K; Sasaki T; Hiraoka K; Nishiyama T; Mizuno T; Asada M; Nunoi H; Matsuda I; Matsuura Y
Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase.
The Journal of biological chemistry 1992;267(36):25709-13.
1992: Yoshida Y; Kawata M; Miura Y; Musha T; Sasaki T; Kikuchi A; Takai Y
Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes.
Molecular and cellular biology 1992;12(8):3407-14.
1992: Kikuchi A; Kuroda S; Sasaki T; Kotani K; Hirata K; Katayama M; Takai Y
Functional interactions of stimulatory and inhibitory GDP/GTP exchange proteins and their common substrate small GTP-binding protein.
The Journal of biological chemistry 1992;267(21):14611-5.
1992: Kuroda S; Kikuchi A; Hirata K; Masuda T; Kishi K; Sasaki T; Takai Y
Cooperative function of rho GDS and rho GDI to regulate rho p21 activation in smooth muscle.
Biochemical and biophysical research communications 1992;185(1):473-80.
1992: Hirata K; Kikuchi A; Sasaki T; Kuroda S; Kaibuchi K; Matsuura Y; Seki H; Saida K; Takai Y
Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.
The Journal of biological chemistry 1992;267(13):8719-22.
1992: Sasaki T; Inui M; Kimura Y; Kuzuya T; Tada M
Molecular mechanism of regulation of Ca2+ pump ATPase by phospholamban in cardiac sarcoplasmic reticulum. Effects of synthetic phospholamban peptides on Ca2+ pump ATPase.
The Journal of biological chemistry 1992;267(3):1674-9.
1991: Shirataki H; Kaibuchi K; Hiroyoshi M; Isomura M; Araki S; Sasaki T; Takai Y
Inhibition of the action of the stimulatory GDP/GTP exchange protein for smg p21 by the geranylgeranylated synthetic peptides designed from its C-terminal region.
The Journal of biological chemistry 1991;266(31):20672-7.
1991: Itoh T; Kaibuchi K; Sasaki T; Takai Y
The smg GDS-induced activation of smg p21 is initiated by cyclic AMP-dependent protein kinase-catalyzed phosphorylation of smg p21.
Biochemical and biophysical research communications 1991;177(3):1319-24.
1991: Sasaki T
A novel type of regulatory protein for the GDP/GTP exchange reaction of smg p25A, a ras p21-like small GTP-binding protein, in bovine brain cytosol.
The Kobe journal of medical sciences 1991;37(3):129-45.
1991: Sasaki T; Kaibuchi K; Kabcenell A K; Novick P J; Takai Y
A mammalian inhibitory GDP/GTP exchange protein (GDP dissociation inhibitor) for smg p25A is active on the yeast SEC4 protein.
Molecular and cellular biology 1991;11(5):2909-12.
1991: Araki S; Kaibuchi K; Sasaki T; Hata Y; Takai Y
Role of the C-terminal region of smg p25A in its interaction with membranes and the GDP/GTP exchange protein.
Molecular and cellular biology 1991;11(3):1438-47.
1991: Takai Y; Kaibuchi K; Kikuchi A; Kawata M; Sasaki T; Yamamoto T
Transforming and c-fos promoter/enhancer-stimulating activities of a GDP/GTP exchange protein for small GTP-binding proteins.
Princess Takamatsu symposia 1991;22():197-204.
1990: Hata Y; Kikuchi A; Sasaki T; Schaber M D; Gibbs J B; Takai Y
Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21s.
The Journal of biological chemistry 1990;265(13):7104-7.
1990: Sasaki T; Kikuchi A; Araki S; Hata Y; Isomura M; Kuroda S; Takai Y
Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein.
The Journal of biological chemistry 1990;265(4):2333-7.
1989: Kikuchi A; Sasaki T; Araki S; Hata Y; Takai Y
Purification and characterization from bovine brain cytosol of two GTPase-activating proteins specific for smg p21, a GTP-binding protein having the same effector domain as c-ras p21s.
The Journal of biological chemistry 1989;264(16):9133-6.

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