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Takehiko Sasaki

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Teiji Wada; Nicholas Joza; Hai-Ying M Cheng; Takehiko Sasaki; Ivona Kozieradzki; Kurt Bachmaier; Toshiaki Katada; Martin Schreiber; Erwin F Wagner; Hiroshi Nishina; Josef M Penninger
MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence.
Gavin Y Oudit; Michael A Crackower; Urs Eriksson; Renu Sarao; Ivona Kozieradzki; Takehiko Sasaki; Junko Irie-Sasaki; Dominica Gidrewicz; Vitalyi O Rybin; Teiji Wada; Susan F Steinberg; Peter H Backx; Josef M Penninger
Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.
Minna Woo; Raza Hakem; Caren Furlonger; Anne Hakem; Gordon S Duncan; Takehiko Sasaki; Denis Bouchard; Liwei Lu; Gillian E Wu; Christopher J Paige; Tak W Mak
Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity.

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All Publications

2004: Teiji Wada; Nicholas Joza; Hai-Ying M Cheng; Takehiko Sasaki; Ivona Kozieradzki; Kurt Bachmaier; Toshiaki Katada; Martin Schreiber; Erwin F Wagner; Hiroshi Nishina; Josef M Penninger
MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence.
Nature cell biology 2004;6(3):215-26.
2003: Gavin Y Oudit; Michael A Crackower; Urs Eriksson; Renu Sarao; Ivona Kozieradzki; Takehiko Sasaki; Junko Irie-Sasaki; Dominica Gidrewicz; Vitalyi O Rybin; Teiji Wada; Susan F Steinberg; Peter H Backx; Josef M Penninger
Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.
Circulation 2003;108(17):2147-52.
2003: Minna Woo; Raza Hakem; Caren Furlonger; Anne Hakem; Gordon S Duncan; Takehiko Sasaki; Denis Bouchard; Liwei Lu; Gillian E Wu; Christopher J Paige; Tak W Mak
Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity.
Nature immunology 2003;4(10):1016-22.
2003: Junko Irie-Sasaki; Takehiko Sasaki; Josef M Penninger
CD45 regulated signaling pathways.
Current topics in medicinal chemistry 2003;3(7):783-96.
2002: Michael A Crackower; Gavin Y Oudit; Ivona Kozieradzki; Renu Sarao; Hui Sun; Takehiko Sasaki; Emilio Hirsch; Akira Suzuki; Tetsuo Shioi; Junko Irie-Sasaki; Rajan Sah; Hai-Ying M Cheng; Vitalyi O Rybin; Giuseppe Lembo; Luigi Fratta; Antonio J Oliveira-dos-Santos; Jeffery L Benovic; C Ronald Kahn; Seigo Izumo; Susan F Steinberg; Matthias P Wymann; Peter H Backx; Josef M Penninger
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways.
Cell 2002;110(6):737-49.
2002: Connie M Krawczyk; Antonio J Oliveira-dos-Santos; Takehiko Sasaki; Emily Griffiths; Pamela S Ohashi; Scott Snapper; Fred Alt; Josef M Penninger
Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells.
Immunity 2002;16(3):331-43.
2001: Takehiko Sasaki; T Wada; Hiroyuki Kishimoto; Junko Irie-Sasaki; Goichi Matsumoto; T Goto; Z Yao; Andrew Wakeham; Tak W Mak; A Suzuki; S K Cho; J C Zuniga-Pflucker; Antonio J Oliveira-dos-Santos; T Katada; Hiroshi Nishina; Josef M Penninger
The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells.
The Journal of experimental medicine 2001;194(6):757-68.
2001: Takehiko Sasaki; J Sasaki; Akira Suzuki; Josef M Penninger
[Involvement of phosphoinositide 3-kinases and phosphoinositide phosphatases in immune responses, glucose metabolism and tumorigenesis].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2001;46(12):1820-9.
2001: Josef M Penninger; Junko Irie-Sasaki; Takehiko Sasaki; Antonio J Oliveira-dos-Santos
CD45: new jobs for an old acquaintance.
Nature immunology 2001;2(5):389-96.
2001: Nicholas Joza; Santos A Susin; Eric Daugas; William L Stanford; S K Cho; C Y Li; Takehiko Sasaki; Andrew Elia; Hai-Ying M Cheng; Luigi Ravagnan; Karine F Ferri; Naoufal Zamzami; Andrew Wakeham; Raza Hakem; H Yoshida; Young-Yun Kong; Tak W Mak; J C Zúñiga-Pflücker; Guido Kroemer; Josef M Penninger
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death.
Nature 2001;410(6828):549-54.
2001: Junko Irie-Sasaki; Takehiko Sasaki; W Matsumoto; A Opavsky; M Cheng; G Grant Welstead; E Griffiths; Connie M Krawczyk; Christopher D Richardson; Karen Aitken; Norman N Iscove; G Koretzky; P Johnson; Peter Liu; David M Rothstein; Josef M Penninger
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling.
Nature 2001;409(6818):349-54.
2000: G Boehmelt; Andrew Wakeham; Andrew Elia; Takehiko Sasaki; Suzanne Plyte; J Potter; Y Yang; E Tsang; Jürgen Ruland; Norman N Iscove; James W Dennis; Tak W Mak
Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells.
The EMBO journal 2000;19(19):5092-104.
2000: Jimmie E Fata; Young-Yun Kong; Joyce Li; Takehiko Sasaki; Junko Irie-Sasaki; Roger A Moorehead; R Elliott; Sheila Scully; EB Voura; David L Lacey; william boyle; Rama Khokha; Josef M Penninger
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development.
Cell 2000;103(1):41-50.
2000: Takehiko Sasaki; Junko Irie-Sasaki; Y Horie; Kurt Bachmaier; Jimmie E Fata; M Li; Akira Suzuki; Denis Bouchard; Alexandra Ho; Mark Redston; Steven Gallinger; Rama Khokha; Tak W Mak; Phillip T Hawkins; Len Stephens; Stephen W Scherer; May Tsao; Josef M Penninger
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma.
Nature 2000;406(6798):897-902.
2000: Takehiko Sasaki; Junko Irie-Sasaki; Russell G Jones; Antonio J Oliveira-dos-Santos; William L Stanford; B Bolon; Andrew Wakeham; Annick Itie; Denis Bouchard; Ivona Kozieradzki; Nicholas Joza; Tak W Mak; Pamela S Ohashi; Akira Suzuki; Josef M Penninger
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.
Science (New York, N.Y.) 2000;287(5455):1040-6.
2000: Kurt Bachmaier; Connie M Krawczyk; Ivona Kozieradzki; Young-Yun Kong; Takehiko Sasaki; Antonio J Oliveira-dos-Santos; Sanjeev Mariathasan; Denis Bouchard; Andrew Wakeham; Annick Itie; J Le; Pamela S Ohashi; Ildiko Sarosi; Hiroshi Nishina; Stan Lipkowitz; Josef M Penninger
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b.
Nature 2000;403(6766):211-6.
1999: Josef M Penninger; Klaus-Dieter Fischer; Takehiko Sasaki; Ivona Kozieradzki; J Le; Kerry Tedford; Kurt Bachmaier; Pamela S Ohashi; Martin F Bachmann
The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation.
European journal of immunology 1999;29(5):1709-18.
1999: Mark A Lomaga; Wen-Chen Yeh; Ildiko Sarosi; Gordon S Duncan; Caren Furlonger; Alexandra Ho; Sean Morony; Charles Capparelli; Gwyneth Van; Stephen Kaufman; A van der Heiden; Annick Itie; Andrew Wakeham; W Khoo; Takehiko Sasaki; Z Cao; Josef M Penninger; Christopher J Paige; David L Lacey; Colin R Dunstan; william boyle; David V Goeddel; Tak W Mak
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
Genes & development 1999;13(8):1015-24.
1999: Anne Hakem; Takehiko Sasaki; Ivona Kozieradzki; Josef M Penninger
The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis.
The Journal of experimental medicine 1999;189(6):957-68.
1999: Hiroshi Nishina; C Vaz; P Billia; Mai Nghiem; Takehiko Sasaki; José Luis de la Pompa; K Furlonger; Christopher J Paige; C Hui; Klaus-Dieter Fischer; Hiroyuki Kishimoto; T Iwatsubo; T Katada; James R Woodgett; Josef M Penninger
Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4.
Development (Cambridge, England) 1999;126(3):505-16.
1998: Akira Suzuki; José Luis de la Pompa; Vuk Stambolic; Andrew Elia; Takehiko Sasaki; I del Barco Barrantes; Alexandra Ho; Andrew Wakeham; Annick Itie; W Khoo; M Fukumoto; Tak W Mak
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice.
Current biology : CB 1998;8(21):1169-78.
1998: Vuk Stambolic; Akira Suzuki; José Luis de la Pompa; Greg M Brothers; Christine Mirtsos; Takehiko Sasaki; Jürgen Ruland; Josef M Penninger; David Siderovski; Tak W Mak
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.
Cell 1998;95(1):29-39.
1998: Hiroshi Nishina; LG Radvanyi; K Raju; Takehiko Sasaki; Ivona Kozieradzki; Josef M Penninger
Impaired TCR-mediated apoptosis and Bcl-XL expression in T cells lacking the stress kinase activator SEK1/MKK4.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(7):3416-20.
1998: Klaus-Dieter Fischer; Young-Yun Kong; Hiroshi Nishina; Kerry Tedford; LE Marengère; Ivona Kozieradzki; Takehiko Sasaki; M Starr; G Chan; S Gardener; Mai Nghiem; Denis Bouchard; M Barbacid; alan bernstein; Josef M Penninger
Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor.
Current biology : CB 1998;8(10):554-62.