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Toshiyasu Sasaoka

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Tsutomu Wada; Hiroshi Tsuneki; Hiroki Fusanobori; Yoko Ishii; Yukari Kimura; Tetsuro Nakano; Yasuhiro Onogi; Masakiyo Sasahara; Toshiyasu Sasaoka
Cilostazol ameliorates systemic insulin resistance in diabetic db/db mice by suppressing chronic inflammation in adipose tissue via modulation of both adipocyte and macrophage functions.
Yoshinori Ichihara; Yuji Matsuya; Kentaro Okamoto; Toshiyasu Sasaoka; Kenji Sugimoto; Ryohei Fujimura; Hiroaki Gouda; Shuichi Hirono; Hiroshi Tsuneki; Tsutomu Wada; Naoki Toyooka
Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2).
Hiroshi Tsuneki; Tsutomu Wada; Takayuki Seki; Takashi Suzuki; Emi Tokai; Ikuko Kimura; Sakuji Koya; Tadashi Okamoto; Kyosuke Okubo; Toshiyasu Sasaoka
Protective effects of coenzyme Q10 against angiotensin II-induced oxidative stress in human umbilical vein endothelial cells.

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2013: Tsutomu Wada; Hiroshi Tsuneki; Hiroki Fusanobori; Yoko Ishii; Yukari Kimura; Tetsuro Nakano; Yasuhiro Onogi; Masakiyo Sasahara; Toshiyasu Sasaoka
Cilostazol ameliorates systemic insulin resistance in diabetic db/db mice by suppressing chronic inflammation in adipose tissue via modulation of both adipocyte and macrophage functions.
European journal of pharmacology 2013;707(1-3):120-9.
2013: Yoshinori Ichihara; Yuji Matsuya; Kentaro Okamoto; Toshiyasu Sasaoka; Kenji Sugimoto; Ryohei Fujimura; Hiroaki Gouda; Shuichi Hirono; Hiroshi Tsuneki; Tsutomu Wada; Naoki Toyooka
Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2).
European journal of medicinal chemistry 2013;62():649-60.
2013: Hiroshi Tsuneki; Tsutomu Wada; Takayuki Seki; Takashi Suzuki; Emi Tokai; Ikuko Kimura; Sakuji Koya; Tadashi Okamoto; Kyosuke Okubo; Toshiyasu Sasaoka
Protective effects of coenzyme Q10 against angiotensin II-induced oxidative stress in human umbilical vein endothelial cells.
European journal of pharmacology 2013;701(1-3):218-27.
2012: Rika Yonezawa; Kanae Sawakawa; Hiroshi Tsuneki; Tsutomu Wada; Yoko Ishii; Natsumi Matsumoto; Mayuko Morita; Shigeru Saito; Masakiyo Sasahara; Toshiyasu Sasaoka
Central versus peripheral impact of estradiol on the impaired glucose metabolism in ovariectomized mice on a high-fat diet.
American journal of physiology. Endocrinology and metabolism 2012;303(4):E445-56.
2012: Toshiyasu Sasaoka
[Perspective of new and future treatment of type 2 diabetes].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 3():707-15.
2012: Toshiyasu Sasaoka; Hiroshi Tsuneki; Tsutomu Wada
[Molecular mechanisms of biological action of insulin].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 3():145-54.
2012: Yasuharu Watanabe; Shizuo Akira; Shiho Fujisaka; Yoichiro Hirata; Yoshinori Ichihara; Sho Ishikawa; Hirofumi Izaki; Hiro-Omi Kanayama; Kensuke Miyake; Tomoya Nakamura; Yoshihiro Ogawa; Toshiyasu Sasaoka; Masataka Sata; Michio Shimabukuro; Takayoshi Suganami; Kiyoshi Takatsu; Kazuyuki Tobe; Koichi tsuneyama; Isao Usui; Tsutomu Wada; Yoshinori Nagai
The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation.
Diabetes 2012;61(5):1199-209.
2012: Hiroshi Tsuneki; Tsutomu Wada; Toshiyasu Sasaoka
Role of orexin in the central regulation of glucose and energy homeostasis.
Endocrine journal 2012;59(5):365-74.
2011: Tsutomu Wada; Masashi Hoshino; Yukari Kimura; Minoru Ojima; Tetsuro Nakano; Daisuke Koya; Hiroshi Tsuneki; Toshiyasu Sasaoka
Both type I and II IFN induce insulin resistance by inducing different isoforms of SOCS expression in 3T3-L1 adipocytes.
American journal of physiology. Endocrinology and metabolism 2011;300(6):E1112-23.
2011: Theodore P Ciaraldi; Toshiyasu Sasaoka
Review on the in vitro interaction of insulin glargine with the insulin/insulin-like growth factor system: potential implications for metabolic and mitogenic activities.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2011;43(1):1-10.
2010: Yoshiyuki Soeda; Hiroshi Tsuneki; Hayato Muranaka; Norihiko Mori; Shuji Hosoh; Yoshinori Ichihara; Syota Kagawa; Xu Wang; Naoki Toyooka; Yusaku Takamura; Teruko Uwano; Hisao Nishijo; Tsutomu Wada; Toshiyasu Sasaoka
The inositol phosphatase SHIP2 negatively regulates insulin/IGF-I actions implicated in neuroprotection and memory function in mouse brain.
Molecular endocrinology (Baltimore, Md.) 2010;24(10):1965-77.
2010: Tsutomu Wada; Satoko Hori; Maine Sugiyama; Eriko Fujisawa; Tetsuro Nakano; Hiroshi Tsuneki; Kiyofumi Nagira; Shigeru Saito; Toshiyasu Sasaoka
Progesterone inhibits glucose uptake by affecting diverse steps of insulin signaling in 3T3-L1 adipocytes.
American journal of physiology. Endocrinology and metabolism 2010;298(4):E881-8.
2009: Tsutomu Takahashi; Michio Suzuki; Masahiko Tsunoda; Nobuhisa Maeno; Yasuhiro Kawasaki; Shi-Yu Zhou; Hirofumi Hagino; Lisha Niu; Hiroshi Tsuneki; Soushi Kobayashi; Toshiyasu Sasaoka; Hikaru Seto; Masayoshi Kurachi; Norio Ozaki
The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia.
Psychiatry research 2009;172(2):128-35.
2009: Tsutomu Wada; Satoshi Ohshima; Eriko Fujisawa; Daisuke Koya; Hiroshi Tsuneki; Toshiyasu Sasaoka
Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes.
Endocrinology 2009;150(4):1662-9.
2008: Tsutomu Wada; Mari Azegami; Maine Sugiyama; Hiroshi Tsuneki; Toshiyasu Sasaoka
Characteristics of signalling properties mediated by long-acting insulin analogue glargine and detemir in target cells of insulin.
Diabetes research and clinical practice 2008;81(3):269-77.
2008: Tsutomu Takahashi; Michio Suzuki; Masahiko Tsunoda; Yukiko Kawamura; Nagahide Takahashi; Nobuhisa Maeno; Yasuhiro Kawasaki; Shi-Yu Zhou; Hirofumi Hagino; Lisha Niu; Hiroshi Tsuneki; Soushi Kobayashi; Toshiyasu Sasaoka; Hikaru Seto; Masayoshi Kurachi; Norio Ozaki
The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesio interthalamica and medial temporal lobe structures.
Progress in neuro-psychopharmacology & biological psychiatry 2008;32(5):1236-42.
2008: Tsutomu Takahashi; Michio Suzuki; Masahiko Tsunoda; Yukiko Kawamura; Nagahide Takahashi; Hiroshi Tsuneki; Yasuhiro Kawasaki; Shi-Yu Zhou; Soushi Kobayashi; Toshiyasu Sasaoka; Hikaru Seto; Masayoshi Kurachi; Norio Ozaki
Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons.
Neuroscience letters 2008;435(1):34-9.
2008: Hiroshi Tsuneki; S Murata; Y Anzawa; Y Soeda; E Tokai; Tsutomu Wada; Ikuko Kimura; M Yanagisawa; T Sakurai; Toshiyasu Sasaoka
Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice.
Diabetologia 2008;51(4):657-67.
2008: Syota Kagawa; Yoshiyuki Soeda; Hajime Ishihara; Takeshi Oya; Masakiyo Sasahara; Saori Yaguchi; Ryo Oshita; Tsutomu Wada; Hiroshi Tsuneki; Toshiyasu Sasaoka
Impact of transgenic overexpression of SH2-containing inositol 5'-phosphatase 2 on glucose metabolism and insulin signaling in mice.
Endocrinology 2008;149(2):642-50.
2007: Naoki Toyooka; Soushi Kobayashi; Dejun Zhou; Hiroshi Tsuneki; Tsutomu Wada; Hideki Sakai; Hideo Nemoto; Toshiyasu Sasaoka; H Martin Garraffo; Thomas F Spande; John W Daly
Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors.
Bioorganic & medicinal chemistry letters 2007;17(21):5872-5.
2007: Isao Usui; Shiho Fujisaka; Katsuya Yamazaki; Atsuko Takano; Shiho Murakami; Yu Yamazaki; Masaharu Urakaze; Haruo Hachiya; Michiyo Takata; Satoko Senda; Minoru Iwata; Akira Satoh; Toshiyasu Sasaoka; Norel Dim Ak; Rie Temaru; Masashi Kobayashi
Telmisartan reduced blood pressure and HOMA-IR with increasing plasma leptin level in hypertensive and type 2 diabetic patients.
Diabetes research and clinical practice 2007;77(2):210-4.
2007: Yoshiaki Ohi; Yoko Ishii; Akira Haji; Shigeru Noguchi; Toshiyasu Sasaoka; Toshihiko Fujimori; Yo-ichi Nabeshima; Masakiyo Sasahara; Yuichi Hattori
Platelet-derived growth factor (PDGF)-BB inhibits AMPA receptor-mediated synaptic transmission via PDGF receptor-beta in murine nucleus tractus solitarius.
Brain research 2007;1159():77-85.
2007: Hiroshi Tsuneki; Naoto Sekizaki; Takashi Suzuki; Shinjiro Kobayashi; Tsutomu Wada; Tadashi Okamoto; Ikuko Kimura; Toshiyasu Sasaoka
Coenzyme Q10 prevents high glucose-induced oxidative stress in human umbilical vein endothelial cells.
European journal of pharmacology 2007;566(1-3):1-10.
2007: Hiroshi Tsuneki; Soushi Kobayashi; Kazue Takagi; Syota Kagawa; Masahiko Tsunoda; Masahiko Murata; Tadasu Matsuoka; Tsutomu Wada; Masayoshi Kurachi; Ikuko Kimura; Toshiyasu Sasaoka
Novel G423S mutation of human alpha7 nicotinic receptor promotes agonist-induced desensitization by a protein kinase C-dependent mechanism.
Molecular pharmacology 2007;71(3):777-86.
2007: Tsutomu Wada; Maiko Naito; Hiroki Kenmochi; Hiroshi Tsuneki; Toshiyasu Sasaoka
Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cells.
Endocrinology 2007;148(2):790-9.
2007: Soushi Kobayashi; Hideo Nemoto; Hideki Sakai; Toshiyasu Sasaoka; Thomas F Spande; Naoki Toyooka; Hiroshi Tsuneki; Tsutomu Wada; Dejun Zhou; H Martin Garraffo; John W Daly
Flexible synthesis of poison-frog alkaloids of the 5,8-disubstituted indolizidine-class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B", (-)-221I, and an epimer of 193E and pharmacological effects at neuronal nicotinic acetylcholine receptors.
Beilstein journal of organic chemistry 2007;3():30.
2006: Toshiyasu Sasaoka; Tsutomu Wada; Hiroshi Tsuneki
Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity.
Pharmacology & therapeutics 2006;112(3):799-809.
2006: Yoko Ishii; Takeshi Oya; Lianshun Zheng; Zhiyang Gao; Makoto Kawaguchi; Hemragul Sabit; Takako Matsushima; Ayano Tokunaga; Shin Ishizawa; Etsuro Hori; Yo-ichi Nabeshima; Toshiyasu Sasaoka; Toshihiko Fujimori; Hisashi Mori; Masakiyo Sasahara
Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury.
Journal of neurochemistry 2006;98(2):588-600.
2006: Kiyofumi Nagira; Toshiyasu Sasaoka; Tsutomu Wada; Kazuhito Fukui; Mariko Ikubo; Satoko Hori; Hiroshi Tsuneki; Shigeru Saito; Masashi Kobayashi
Altered subcellular distribution of estrogen receptor alpha is implicated in estradiol-induced dual regulation of insulin signaling in 3T3-L1 adipocytes.
Endocrinology 2006;147(2):1020-8.
2006: Jianying He; Isao Usui; Ken Ishizuka; Yukiko Kanatani; Kazuyuki Hiratani; Minoru Iwata; Agussalim Bukhari; Tetsuro Haruta; Toshiyasu Sasaoka; Masashi Kobayashi
Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) 2006;20(1):114-24.
2005: Kazuhito Fukui; Tsutomu Wada; Syota Kagawa; Kiyofumi Nagira; Mariko Ikubo; Hajime Ishihara; Masashi Kobayashi; Toshiyasu Sasaoka
Impact of the liver-specific expression of SHIP2 (SH2-containing inositol 5'-phosphatase 2) on insulin signaling and glucose metabolism in mice.
Diabetes 2005;54(7):1958-67.
2005: Syota Kagawa; Toshiyasu Sasaoka; Saori Yaguchi; Hajime Ishihara; Hiroshi Tsuneki; Shihou Murakami; Kazuhito Fukui; Tsutomu Wada; Soushi Kobayashi; Ikuko Kimura; Masashi Kobayashi
Impact of SRC homology 2-containing inositol 5'-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signaling.
The Journal of clinical endocrinology and metabolism 2005;90(5):2911-9.
2005: Hiroshi Tsuneki; En-Long Ma; Shinjiro Kobayashi; Naoto Sekizaki; Kouji Maekawa; Toshiyasu Sasaoka; Min-Wei Wang; Ikuko Kimura
Antiangiogenic activity of beta-eudesmol in vitro and in vivo.
European journal of pharmacology 2005;512(2-3):105-15.
2005: Hiroshi Tsuneki; Yueren You; Naoki Toyooka; Toshiyasu Sasaoka; Hideo Nemoto; John A Dani; Ikuko Kimura
Marine alkaloids (-)-pictamine and (-)-lepadin B block neuronal nicotinic acetylcholine receptors.
Biological & pharmaceutical bulletin 2005;28(4):611-4.
2005: Zhiyang Gao; Toshiyasu Sasaoka; Toshihiko Fujimori; Takeshi Oya; Yoko Ishii; Hemragul Sabit; Makoto Kawaguchi; Yoko Kurotaki; Maiko Naito; Tsutomu Wada; Shin Ishizawa; Masashi Kobayashi; Yo-ichi Nabeshima; Masakiyo Sasahara
Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing.
The Journal of biological chemistry 2005;280(10):9375-89.
2005: Toshiyasu Sasaoka; K Fukui; Tsutomu Wada; S Murakami; Junko Kawahara; Hajime Ishihara; M Funaki; T Asano; Masashi Kobayashi
Inhibition of endogenous SHIP2 ameliorates insulin resistance caused by chronic insulin treatment in 3T3-L1 adipocytes.
Diabetologia 2005;48(2):336-44.
2004: Hiroshi Tsuneki; Kana Ito; Naoto Sekizaki; En-Long Ma; Yueren You; Junichi Kawakami; Isao Adachi; Toshiyasu Sasaoka; Ikuko Kimura
Nicotinic enhancement of proliferation in bovine and porcine cerebral microvascular endothelial cells.
Biological & pharmaceutical bulletin 2004;27(12):1951-6.
2004: Hiroshi Tsuneki; Yueren You; Naoki Toyooka; Syota Kagawa; Soushi Kobayashi; Toshiyasu Sasaoka; Hideo Nemoto; Ikuko Kimura; John A Dani
Alkaloids indolizidine 235B', quinolizidine 1-epi-207I, and the tricyclic 205B are potent and selective noncompetitive inhibitors of nicotinic acetylcholine receptors.
Molecular pharmacology 2004;66(4):1061-9.
2004: Hiroshi Tsuneki; Mitsuyo Ishizuka; Miki Terasawa; Jin-Bin Wu; Toshiyasu Sasaoka; Ikuko Kimura
Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans.
BMC pharmacology 2004;4():18.
2004: Shihou Murakami; Toshiyasu Sasaoka; Tsutomu Wada; Kazuhito Fukui; Kiyofumi Nagira; Hajime Ishihara; Isao Usui; Masashi Kobayashi
Impact of Src homology 2-containing inositol 5'-phosphatase 2 on the regulation of insulin signaling leading to protein synthesis in 3T3-L1 adipocytes cultured with excess amino acids.
Endocrinology 2004;145(7):3215-23.
2004: Toshiyasu Sasaoka; Tsutomu Wada; Kazuhito Fukui; Shihou Murakami; Hajime Ishihara; Ryo Suzuki; Kazuyuki Tobe; Takashi Kadowaki; Masashi Kobayashi
SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes.
The Journal of biological chemistry 2004;279(15):14835-43.
2004: Minoru Iwata; Yuki Yamamoto; Tadashi Fujita; Ryuuji Hayashi; Yasushi Igarashi; Akira Satou; Toshiyasu Sasaoka; Muneharu Maruyama; Masashi Kobayashi; Kazuhiro Matsui
[Ectopic ACTH-producing bronchial carcinoid tumor].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2004;93(2):370-2.
2003: Hajime Ishihara; Toshiyasu Sasaoka; Syota Kagawa; Shihou Murakami; Kazuhito Fukui; Yukio Kawagishi; Katsuya Yamazaki; Akira Sato; Minoru Iwata; Masaharu Urakaze; Manabu Ishiki; Tsutomu Wada; Saori Yaguchi; Hiroshi Tsuneki; Ikuko Kimura; Masashi Kobayashi
Association of the polymorphisms in the 5'-untranslated region of PTEN gene with type 2 diabetes in a Japanese population.
FEBS letters 2003;554(3):450-4.
2003: Toshiyasu Sasaoka; Kosei Kikuchi; Tsutomu Wada; Akira Sato; Hiroyuki Hori; Shihou Murakami; Kazuhito Fukui; Hajime Ishihara; Rina Aota; Ikuko Kimura; Masashi Kobayashi
Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells.
Endocrinology 2003;144(9):4204-14.
2003: Ying-Luan Zhao; Kiyoshi Takagawa; Takeshi Oya; Hong-Fa Yang; Zhi-Yang Gao; Makoto Kawaguchi; Yoko Ishii; Toshiyasu Sasaoka; Koji Owada; Isao Furuta; Masakiyo Sasahara
Active Src expression is induced after rat peripheral nerve injury.
Glia 2003;42(2):184-93.
2002: Hajime Ishihara; Toshiyasu Sasaoka; Manabu Ishiki; Tsutomu Wada; Hiroyuki Hori; Syota Kagawa; Masashi Kobayashi
Membrane localization of Src homology 2-containing inositol 5'-phosphatase 2 via Shc association is required for the negative regulation of insulin signaling in Rat1 fibroblasts overexpressing insulin receptors.
Molecular endocrinology (Baltimore, Md.) 2002;16(10):2371-81.
2002: Hiroyuki Hori; Toshiyasu Sasaoka; Hajime Ishihara; Tsutomu Wada; Shihou Murakami; Manabu Ishiki; Masashi Kobayashi
Association of SH2-containing inositol phosphatase 2 with the insulin resistance of diabetic db/db mice.
Diabetes 2002;51(8):2387-94.
2002: Hiroshi Tsuneki; Yoshitaka Sugihara; Ritsu Honda; Tsutomu Wada; Toshiyasu Sasaoka; Ikuko Kimura
Reduction of blood glucose level by orexins in fasting normal and streptozotocin-diabetic mice.
European journal of pharmacology 2002;448(2-3):245-52.
2002: Toshiyasu Sasaoka
[Glucose intolerance induced by interferon therapy].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():760-5.
2001: Toshiyasu Sasaoka; Manabu Ishiki; Tsutomu Wada; Hiroyuki Hori; H Hirai; Tetsuro Haruta; Hajime Ishihara; Masashi Kobayashi
Tyrosine phosphorylation-dependent and -independent role of Shc in the regulation of IGF-1-induced mitogenesis and glycogen synthesis.
Endocrinology 2001;142(12):5226-35.
2001: Toshiyasu Sasaoka; Hiroyuki Hori; Tsutomu Wada; Manabu Ishiki; Tetsuro Haruta; Hajime Ishihara; Masashi Kobayashi
SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes.
Diabetologia 2001;44(10):1258-67.
2001: Atsuko Takano; Tetsuro Haruta; Minoru Iwata; Isao Usui; T Uno; Junko Kawahara; E Ueno; Toshiyasu Sasaoka; Masashi Kobayashi
Growth hormone induces cellular insulin resistance by uncoupling phosphatidylinositol 3-kinase and its downstream signals in 3T3-L1 adipocytes.
Diabetes 2001;50(8):1891-900.
2001: Akira Sato; Toshiyasu Sasaoka; Katsuya Yamazaki; Norio Nakamura; Rie Temaru; Manabu Ishiki; Masanobu Takata; Mika Kishida; Tsutomu Wada; Hajime Ishihara; Isao Usui; Masaharu Urakaze; Masashi Kobayashi
Glucosamine enhances platelet-derived growth factor-induced DNA synthesis via phosphatidylinositol 3-kinase pathway in rat aortic smooth muscle cells.
Atherosclerosis 2001;157(2):341-52.
2001: E Ueno; Tetsuro Haruta; T Uno; Isao Usui; Minoru Iwata; Atsuko Takano; Junko Kawahara; Toshiyasu Sasaoka; O Ishibashi; Masashi Kobayashi
Potential role of Gab1 and phospholipase C-gamma in osmotic shock-induced glucose uptake in 3T3-L1 adipocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2001;33(7):402-6.
2001: Minoru Iwata; Tetsuro Haruta; Isao Usui; Yoshimi Takata; Atsuko Takano; T Uno; Junko Kawahara; E Ueno; Toshiyasu Sasaoka; O Ishibashi; Masashi Kobayashi
Pioglitazone ameliorates tumor necrosis factor-alpha-induced insulin resistance by a mechanism independent of adipogenic activity of peroxisome proliferator--activated receptor-gamma.
Diabetes 2001;50(5):1083-92.
2001: Tsutomu Wada; Toshiyasu Sasaoka; M Funaki; Hiroyuki Hori; S Murakami; Manabu Ishiki; Tetsuro Haruta; T Asano; W Ogawa; Hajime Ishihara; Masashi Kobayashi
Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity.
Molecular and cellular biology 2001;21(5):1633-46.
2000: Isao Usui; Tetsuro Haruta; Minoru Iwata; Atsuko Takano; T Uno; Junko Kawahara; E Ueno; Toshiyasu Sasaoka; Masashi Kobayashi
Retinoblastoma protein phosphorylation via PI 3-kinase and mTOR pathway regulates adipocyte differentiation.
Biochemical and biophysical research communications 2000;275(1):115-20.
2000: Toshiyasu Sasaoka; Masashi Kobayashi
The functional significance of Shc in insulin signaling as a substrate of the insulin receptor.
Endocrine journal 2000;47(4):373-81.
2000: Toshiyasu Sasaoka; Masashi Kobayashi
[Relative importance of insulin actin in insulin's target tissues].
Nihon rinsho. Japanese journal of clinical medicine 2000;58(2):291-6.
1999: T Sawa; Toshiyasu Sasaoka; H Hirai; Hajime Ishihara; Manabu Ishiki; Tsutomu Wada; Masashi Kobayashi
Intracellular signalling pathways of okadaic acid leading to mitogenesis in Rat1 fibroblast overexpressing insulin receptors: okadaic acid regulates Shc phosphorylation by mechanisms independent of insulin.
Cellular signalling 1999;11(11):797-803.
1999: Isao Usui; Tetsuro Haruta; Yoshimi Takata; Minoru Iwata; T Uno; Atsuko Takano; E Ueno; O Ishibashi; Hajime Ishihara; Tsutomu Wada; Toshiyasu Sasaoka; Masashi Kobayashi
Differential effects of palmitate on glucose uptake in rat-1 fibroblasts and 3T3-L1 adipocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1999;31(10):546-52.
1999: Tsutomu Wada; Toshiyasu Sasaoka; Manabu Ishiki; Hiroyuki Hori; Tetsuro Haruta; Hajime Ishihara; Masashi Kobayashi
Role of the Src homology 2 (SH2) domain and C-terminus tyrosine phosphorylation sites of SH2-containing inositol phosphatase (SHIP) in the regulation of insulin-induced mitogenesis.
Endocrinology 1999;140(10):4585-94.
1999: Toshiyasu Sasaoka; Tsutomu Wada; Hajime Ishihara; Yoshimi Takata; Tetsuro Haruta; Isao Usui; Manabu Ishiki; Masashi Kobayashi
Synergistic role of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase cascade in the regulation of insulin receptor trafficking.
Endocrinology 1999;140(8):3826-34.
1999: Hajime Ishihara; Toshiyasu Sasaoka; Hiroyuki Hori; Tsutomu Wada; H Hirai; Tetsuro Haruta; W J Langlois; Masashi Kobayashi
Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling.
Biochemical and biophysical research communications 1999;260(1):265-72.
1998: Hajime Ishihara; Toshiyasu Sasaoka; Tsutomu Wada; Manabu Ishiki; Tetsuro Haruta; Isao Usui; Minoru Iwata; Atsuko Takano; T Uno; E Ueno; Masashi Kobayashi
Relative involvement of Shc tyrosine 239/240 and tyrosine 317 on insulin induced mitogenic signaling in rat1 fibroblasts expressing insulin receptors.
Biochemical and biophysical research communications 1998;252(1):139-44.
1998: T Imamura; Tetsuro Haruta; Yoshimi Takata; Isao Usui; Minoru Iwata; Hajime Ishihara; Manabu Ishiki; O Ishibashi; E Ueno; Toshiyasu Sasaoka; Masashi Kobayashi
Involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome.
The Journal of biological chemistry 1998;273(18):11183-8.
1997: Manabu Ishiki; Toshiyasu Sasaoka; Hajime Ishihara; T Imamura; Isao Usui; Yoshimi Takata; Masashi Kobayashi
Evidence for functional roles of Crk-II in insulin and epidermal growth factor signaling in Rat-1 fibroblasts overexpressing insulin receptors.
Endocrinology 1997;138(11):4950-8.
1997: Yoshimi Takata; T Imamura; Minoru Iwata; Isao Usui; Tetsuro Haruta; N Nandachi; Manabu Ishiki; Toshiyasu Sasaoka; Masashi Kobayashi
Functional importance of heat shock protein 90 associated with insulin receptor on insulin-stimulated mitogenesis.
Biochemical and biophysical research communications 1997;237(2):345-7.
1997: Isao Usui; Yoshimi Takata; T Imamura; H Morioka; Toshiyasu Sasaoka; T Sawa; Hajime Ishihara; Manabu Ishiki; Masashi Kobayashi
Fatty acid induced insulin resistance in rat-1 fibroblasts overexpressing human insulin receptors: impaired insulin-stimulated mitogen-activated protein kinase activity.
Diabetologia 1997;40(8):894-901.
1997: Hajime Ishihara; Toshiyasu Sasaoka; Manabu Ishiki; Yoshimi Takata; T Imamura; Isao Usui; W J Langlois; T Sawa; Masashi Kobayashi
Functional importance of Shc tyrosine 317 on insulin signaling in Rat1 fibroblasts expressing insulin receptors.
The Journal of biological chemistry 1997;272(14):9581-6.
1996: Yoshimi Takata; T Imamura; Tetsuro Haruta; Toshiyasu Sasaoka; H Morioka; Hajime Ishihara; T Sawa; Isao Usui; Manabu Ishiki; Masashi Kobayashi
The dominant negative effect of a kinase-defective insulin receptor on insulin-like growth factor-I-stimulated signaling in Rat-1 fibroblasts.
Metabolism: clinical and experimental 1996;45(12):1474-82.
1996: Toshiyasu Sasaoka; Manabu Ishiki; T Sawa; Hajime Ishihara; Yoshimi Takata; T Imamura; Isao Usui; Jerrold M Olefsky; Masashi Kobayashi
Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways.
Endocrinology 1996;137(10):4427-34.
1996: Toshiyasu Sasaoka; Hajime Ishihara; T Sawa; Manabu Ishiki; H Morioka; T Imamura; Isao Usui; Yoshimi Takata; Masashi Kobayashi
Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner.
The Journal of biological chemistry 1996;271(33):20082-7.
1996: Toshiyasu Sasaoka; W J Langlois; F Bai; David W Rose; J Wayne Leitner; S J Decker; Alan Saltiel; G N Gill; Masashi Kobayashi; Boris Draznin; Jerrold M Olefsky
Involvement of ErbB2 in the signaling pathway leading to cell cycle progression from a truncated epidermal growth factor receptor lacking the C-terminal autophosphorylation sites.
The Journal of biological chemistry 1996;271(14):8338-44.
1996: T Sawa; T Imamura; Tetsuro Haruta; Toshiyasu Sasaoka; Manabu Ishiki; Yoshimi Takata; Y Takada; H Morioka; Hajime Ishihara; Isao Usui; Masashi Kobayashi
Hsp70 family molecular chaperones and mutant insulin receptor: differential binding specificities of BiP and Hsp70/Hsc70 determines accumulation or degradation of insulin receptor.
Biochemical and biophysical research communications 1996;218(2):449-53.
1995: W J Langlois; Toshiyasu Sasaoka; Alan Saltiel; Jerrold M Olefsky
Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation.
The Journal of biological chemistry 1995;270(43):25320-3.
1995: J Langlois; W Leitner; J Medh; Toshiyasu Sasaoka; Jerrold M Olefsky; Boris Draznin
Mechanism of activation of guanine nucleotide exchange factor by insulin.
Endocrine 1995;3(7):475-9.
1995: B H Jhun; T Haruta; Judy L Meinkoth; W Leitner; Boris Draznin; Alan Saltiel; L Pang; Toshiyasu Sasaoka; Jerrold M Olefsky
Signal transduction pathways leading to insulin-induced early gene induction.
Biochemistry 1995;34(25):7996-8004.
1995: Toshiyasu Sasaoka; W J Langlois; David W Rose; Jerrold M Olefsky
Mechanisms of enhanced transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain.
The Journal of biological chemistry 1995;270(18):10885-92.
1995: W J Langlois; Toshiyasu Sasaoka; C C Yip; Jerrold M Olefsky
Functional characterization of hybrid receptors composed of a truncated insulin receptor and wild type insulin-like growth factor 1 or insulin receptors.
Endocrinology 1995;136(5):1978-86.
1995: T S Pillay; Toshiyasu Sasaoka; Jerrold M Olefsky
Insulin stimulates the tyrosine dephosphorylation of pp125 focal adhesion kinase.
The Journal of biological chemistry 1995;270(3):991-4.
1994: Toshiyasu Sasaoka; W J Langlois; J Wayne Leitner; Boris Draznin; Jerrold M Olefsky
The signaling pathway coupling epidermal growth factor receptors to activation of p21ras.
The Journal of biological chemistry 1994;269(51):32621-5.
1994: T Imamura; Yoshimi Takata; Toshiyasu Sasaoka; Y Takada; H Morioka; Tetsuro Haruta; T Sawa; M Iwanishi; Y G Hu; Y Suzuki
Two naturally occurring mutations in the kinase domain of insulin receptor accelerate degradation of the insulin receptor and impair the kinase activity.
The Journal of biological chemistry 1994;269(49):31019-27.
1994: W J Langlois; J Medh; J Wayne Leitner; Toshiyasu Sasaoka; Jerrold M Olefsky; Boris Draznin
Insulin and epidermal growth factor influence guanine nucleotide-releasing factor by distinct mechanisms.
Endocrinology 1994;135(6):2412-7.
1994: S Xiao; David W Rose; Toshiyasu Sasaoka; H Maegawa; T R Burke; P P Roller; S E Shoelson; Jerrold M Olefsky
Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction.
The Journal of biological chemistry 1994;269(33):21244-8.
1994: Toshiyasu Sasaoka; David W Rose; B H Jhun; Alan Saltiel; Boris Draznin; Jerrold M Olefsky
Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor.
The Journal of biological chemistry 1994;269(18):13689-94.
1994: Toshiyasu Sasaoka; Boris Draznin; J Wayne Leitner; W J Langlois; Jerrold M Olefsky
Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.
The Journal of biological chemistry 1994;269(14):10734-8.
1993: Toshiyasu Sasaoka; Yoshimi Takata; J Kusari; C M Anderson; W J Langlois; Jerrold M Olefsky
Transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4379-83.
1993: M Iwanishi; Tetsuro Haruta; Yoshimi Takata; O Ishibashi; Toshiyasu Sasaoka; K Egawa; T Imamura; K Naitou; T Itazu; Masashi Kobayashi
A mutation (Trp1193-->Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance.
Diabetologia 1993;36(5):414-22.
1993: RM Smith; Toshiyasu Sasaoka; N Shah; Yoshimi Takata; J Kusari; Jerrold M Olefsky; Leonard Jarett
A truncated human insulin receptor missing the COOH-terminal 365 amino acid residues does not undergo insulin-mediated receptor migration or aggregation.
Endocrinology 1993;132(4):1453-62.
1990: Masashi Kobayashi; M Sugibayashi; Toshiyasu Sasaoka; K Egawa; Y Shigeta; M Tamaki; E Nakamura; H Teraoka
Transfection of cDNA with G----T point mutation at the cleavage site of insulin receptors to COS 7 cells.
Biochemical and biophysical research communications 1990;167(3):1073-8.
1989: Toshiyasu Sasaoka; Y Shigeta; Y Takata; O Ishibashi; M Sugibayashi; A Hisatomi; Masashi Kobayashi
Unprocessed insulin proreceptor in cultured fibroblasts from a patient with extreme insulin resistance.
Metabolism: clinical and experimental 1989;38(10):990-6.
1989: Masashi Kobayashi; Toshiyasu Sasaoka; M Sugibayashi; M Iwanishi; Y Shigeta
Receptor binding and biologic activity of biosynthetic human insulin and mini-proinsulin produced by recombinant gene technology.
Diabetes research and clinical practice 1989;7(1):25-8.
1989: Toshiyasu Sasaoka; Y Shigeta; Y Takata; M Sugibayashi; A Hisatomi; Masashi Kobayashi
Binding specificity and intramolecular signal transmission of uncleaved insulin proreceptor in transformed lymphocytes from a patient with extreme insulin resistance.
Diabetologia 1989;32(6):371-7.
1989: O Ishibashi; Masashi Kobayashi; Toshiyasu Sasaoka; M Sugibayashi; Y Shigeta
W-7 specifically inhibits insulin-induced increase in glucose transport.
Diabetes research and clinical practice 1989;6(2):109-13.
1989: Masashi Kobayashi; Toshiyasu Sasaoka; Y Takata; O Ishibashi; M Sugibayashi; A Hisatomi; H Teraoka; Y Shigeta
Unprocessed insulin proreceptors due to point mutation at the cleavage site.
Diabetes research and clinical practice 1989;7 Suppl 1():S35-9.
1988: Toshiyasu Sasaoka; Masashi Kobayashi; Y Takata; O Ishibashi; M Iwasaki; Y Shigeta; K Goji; A Hisatomi
Clarification of signaling pathways mediated by insulin and insulin-like growth factor I receptors in fibroblasts from patients with specific defect in insulin receptor.
Diabetes 1988;37(11):1515-23.
1988: T Watarai; Masashi Kobayashi; Y Takata; Toshiyasu Sasaoka; M Iwasaki; Y Shigeta
Alteration of insulin-receptor kinase activity by high-fat feeding.
Diabetes 1988;37(10):1397-404.
1988: Masashi Kobayashi; Toshiyasu Sasaoka; Y Takata; O Ishibashi; M Sugibayashi; Y Shigeta; A Hisatomi; E Nakamura; M Tamaki; H Teraoka
Insulin resistance by unprocessed insulin proreceptors point mutation at the cleavage site.
Biochemical and biophysical research communications 1988;153(2):657-63.
1988: Masashi Kobayashi; Toshiyasu Sasaoka; Y Takata; A Hisatomi; Y Shigeta
Insulin resistance by uncleaved insulin proreceptor. Emergence of binding site by trypsin.
Diabetes 1988;37(5):653-6.
1988: Masashi Kobayashi; Y Takata; Toshiyasu Sasaoka; Y Shigeta; K Goji
Fluctuation of insulin resistance in a leprechaun with a primary defect in insulin binding.
The Journal of clinical endocrinology and metabolism 1988;66(5):1084-8.