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Jack Satsangi

Research Profile

Disorders

Physiology

Chemicals & Drugs

Procedures

Case Control Studies

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Scotland

Concepts & Ideas

Genes & Molecular Sequences

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Publications

TOP 3
Craig Stevens; David C Wilson; Kenneth W Simpson; Dinesh C Soares; Jeffrey C Barrett; Belgin Dogan; Paul Henderson; Elaine R Nimmo; Jack Satsangi
The intermediate filament protein, vimentin, is a regulator of NOD2 activity.
Aleixo Muise; Ryan Murchie; Andrew D Paterson; Richard K Russell; Jack Satsangi; Mary Sherlock; Mark S Silverberg; Thomas D Walters; David C Wilson; Victorien M Wolters; Wei Xu; Judy H Cho; Richard H Duerr; Ramzi Fattouh; Juan Cristóbal Gana; Michael Glogauer; Anne M Griffiths; Cong-Hui Guo; Pingzhao Hu; Grace Y Lam; Charles W Lees; John H Brumell
NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2.
Paul Henderson; Emma L Reynish; Pam Rogers; Richard K Russell; Jack Satsangi; Johan Van Limbergen; Niall H Anderson; WM Bisset; Fiona L Cameron; Hazel E Drummond; Kostas Gerasimidis; Richard Hansen; David C Wilson
Rising incidence of pediatric inflammatory bowel disease in Scotland.

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All Publications

2013: Craig Stevens; David C Wilson; Kenneth W Simpson; Dinesh C Soares; Jeffrey C Barrett; Belgin Dogan; Paul Henderson; Elaine R Nimmo; Jack Satsangi
The intermediate filament protein, vimentin, is a regulator of NOD2 activity.
Gut 2013;62(5):695-707.
2012: Aleixo Muise; Ryan Murchie; Andrew D Paterson; Richard K Russell; Jack Satsangi; Mary Sherlock; Mark S Silverberg; Thomas D Walters; David C Wilson; Victorien M Wolters; Wei Xu; Judy H Cho; Richard H Duerr; Ramzi Fattouh; Juan Cristóbal Gana; Michael Glogauer; Anne M Griffiths; Cong-Hui Guo; Pingzhao Hu; Grace Y Lam; Charles W Lees; John H Brumell
NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2.
Gut 2012;61(7):1028-35.
2012: Paul Henderson; Emma L Reynish; Pam Rogers; Richard K Russell; Jack Satsangi; Johan Van Limbergen; Niall H Anderson; WM Bisset; Fiona L Cameron; Hazel E Drummond; Kostas Gerasimidis; Richard Hansen; David C Wilson
Rising incidence of pediatric inflammatory bowel disease in Scotland.
Inflammatory bowel diseases 2012;18(6):999-1005.
2012: Elaine R Nimmo; James G Prendergast; Bernard H Ramsahoye; Marian C Aldhous; Hazel E Drummond; Paul Henderson; Nicholas A Kennedy; Colin A Semple; David C Wilson; Jack Satsangi
Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway.
Inflammatory bowel diseases 2012;18(5):889-99.
2011: Charles W Lees; Miles Parkes; J C Barrett; Jack Satsangi
New IBD genetics: common pathways with other diseases.
Gut 2011;60(12):1739-53.
2011: C A Parisinos; Charles W Lees; W A H Wallace; Jack Satsangi
Sarcoidosis complicating treatment with natalizumab for Crohn's disease.
Thorax 2011;66(12):1109-10.
2011: Jack Satsangi; David C Wilson; P Henderson; N A Kennedy; Elaine R Nimmo
Exploring the hidden heritability of inflammatory bowel disease.
Gut 2011;60(11):1447-8.
2011: Paul Henderson; Elaine R Nimmo; Richard K Russell; Jack Satsangi; Johan Van Limbergen; Niall H Anderson; David C Wilson
Variation in ICOSLG influences Crohn's disease susceptibility.
Gut 2011;60(10):1444.
2011: Elaine R Nimmo; Colin L Noble; Anne M Phillips; Michael Quail; Marian C Aldhous; Gail Davies; Hazel E Drummond; Amanda Smith; Craig Stevens; David C Wilson; Jack Satsangi
TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease.
Gastroenterology 2011;141(3):972-981.e1-2.
2011: Aleixo Muise; Bo-Yee Ngan; Andrew D Paterson; Paul Renbaum; Jack Satsangi; Grace Shen-Tu; Philip M Sherman; Mark S Silverberg; Dan Turner; Johan Van Limbergen; Thomas Walters; David C Wilson; Victorien M Wolters; Wei Xu; Judy Cho; Lee A Denson; Richard H Duerr; Ramzi Fattouh; Michael Glogauer; Anne M Griffiths; Cong-Hui Guo; Yair Kasirer; Grace Y Lam; Charlie W Lees; Joshua Bennitz; John H Brumell
Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis.
Gastroenterology 2011;141(2):633-41.
2011: Craig Mowat; Andrew Cole; Al Windsor; Tariq Ahmad; Ian Arnott; Richard Driscoll; Sally Mitton; Tim Orchard; Matt Rutter; Lisa Younge; Charlie Lees; Gwo-Tzer Ho; Jack Satsangi; Stuart Bloom
Guidelines for the management of inflammatory bowel disease in adults.
Gut 2011;60(5):571-607.
2011: Vibeke Andersen; Elaine Nimmo; Henrik Krarup; Hazel Drummond; Jane Christensen; Gwo-Tzer Ho; Mette Ostergaard; Anja Ernst; Charlie Lees; Bent A Jacobsen; Jack Satsangi; Ulla Vogel
Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study.
Inflammatory bowel diseases 2011;17(4):937-46.
2011: Marian C Aldhous; Malcolm G Dunlop; Jennifer E Easterbrook; Kimberley Soo; Lesley A Stark; Agata A Ulanicka; Jack Satsangi
Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells.
PloS one 2011;6(9):e24715.
2011: Simon Travis; Jack Satsangi; Marc Lémann
Predicting the need for colectomy in severe ulcerative colitis: a critical appraisal of clinical parameters and currently available biomarkers.
Gut 2011;60(1):3-9.
2011: Yao Lin; Paul Henderson; Susanne Pettersson; Jack Satsangi; Ted Hupp; Craig Stevens
Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway.
The FEBS journal 2011;278(2):354-70.
2010: Colin L Noble; Alexander R Abbas; Charles W Lees; Jennine Cornelius; Karen Toy; Zora Modrusan; Hilary F Clark; I D R Arnott; Ian D Penman; Jack Satsangi; Lauri Diehl
Characterization of intestinal gene expression profiles in Crohn's disease by genome-wide microarray analysis.
Inflammatory bowel diseases 2010;16(10):1717-28.
2010: C A Parisinos; V E D McIntyre; T Heron; D Subedi; I D R Arnott; C Mowat; David C Wilson; S McGurk; S Glancy; I A Zealley; Jack Satsangi; C W Lees
Magnetic resonance follow-through imaging for evaluation of disease activity in ileal Crohn's disease: an observational, retrospective cohort study.
Inflammatory bowel diseases 2010;16(7):1219-26.
2009: Charles W Lees; J Critchley; N Chee; T Beez; R E Gailer; Alistair R W Williams; Alan G Shand; I D R Arnott; Jack Satsangi
Lack of association between cervical dysplasia and IBD: a large case-control study.
Inflammatory bowel diseases 2009;15(11):1621-9.
2009: Charlie W Lees; Jack Satsangi
Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history.
Expert review of gastroenterology & hepatology 2009;3(5):513-34.
2009: Marco Zucchelli; Leif Torkvist; Francesca Bresso; Jonas Halfvarson; Anna Hellquist; Francesca Anedda; Ghazaleh Assadi; Gunnar B Lindgren; Monika Svanfeldt; Martin Janson; Colin L Noble; Sven Pettersson; Maija Lappalainen; Paulina Paavola-Sakki; Leena Halme; Martti Färkkilä; Ulla Turunen; Jack Satsangi; Kimmo Kontula; Robert Löfberg; Juha Kere; Mauro D'Amato
PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease.
Inflammatory bowel diseases 2009;15(10):1562-9.
2009: J Van Limbergen; Richard K Russell; Elaine R Nimmo; Y Zhao; H Liao; Hazel E Drummond; G Davies; P M Gillett; P McGrogan; W M Bisset; G Mahdi; David C Wilson; S J Brown; W H I McLean; Jack Satsangi
Filaggrin loss-of-function variants are associated with atopic comorbidity in pediatric inflammatory bowel disease.
Inflammatory bowel diseases 2009;15(10):1492-8.
2009: J Van Limbergen; C Stevens; Elaine R Nimmo; D C Wilson; Jack Satsangi
Autophagy: from basic science to clinical application.
Mucosal immunology 2009;2(4):315-30.
2009: Charles W Lees; A I Ali; A I Thompson; Gwo-Tzer Ho; R O Forsythe; L Marquez; C J Cochrane; S Aitken; Janice Fennell; P Rogers; Alan G Shand; Ian D Penman; Kelvin R Palmer; David C Wilson; I D R Arnott; Jack Satsangi
The safety profile of anti-tumour necrosis factor therapy in inflammatory bowel disease in clinical practice: analysis of 620 patient-years follow-up.
Alimentary pharmacology & therapeutics 2009;29(3):286-97.
2009: Marian C Aldhous; Colin L Noble; Jack Satsangi
Dysregulation of human beta-defensin-2 protein in inflammatory bowel disease.
PloS one 2009;4(7):e6285.
2008: Charlie W Lees; William J Zacharias; Mark Tremelling; Colin L Noble; Elaine R Nimmo; Albert Tenesa; Jennine Cornelius; Leif Torkvist; John Y Kao; Susan Farrington; Hazel E Drummond; Gwo-Tzer Ho; Ian D R Arnott; Henry D Appelman; Lauri Diehl; Harry Campbell; Malcolm G Dunlop; Miles Parkes; Sarah E M Howie; Deborah L Gumucio; Jack Satsangi
Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways.
PLoS medicine 2008;5(12):e239.
2008: Marian C Aldhous; Robin J Prescott; Simon Roberts; Kay Samuel; Martin Waterfall; Jack Satsangi
Does nicotine influence cytokine profile and subsequent cell cycling/apoptotic responses in inflammatory bowel disease?
Inflammatory bowel diseases 2008;14(11):1469-82.
2008: Jack Satsangi
What do the terms "genetic predisposition" and "genetic heterogeneity" mean in relation to inflammatory bowel disease?
Inflammatory bowel diseases 2008;14 Suppl 2():S31-2.
2008: Johan Van Limbergen; Richard K Russell; Hazel E Drummond; Marian C Aldhous; Nicola K Round; Elaine R Nimmo; Linda Smith; Peter M Gillett; Paraic McGrogan; Lawrence T Weaver; WM Bisset; Gamal Mahdi; I D R Arnott; Jack Satsangi; David C Wilson
Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease.
Gastroenterology 2008;135(4):1114-22.
2008: Colin L Noble; Alex Abbas; J Cornelius; Charles W Lees; Gwo-Tzer Ho; K Toy; Z Modrusan; N Pal; F Zhong; S Chalasani; H Clark; I D R Arnott; Ian D Penman; Jack Satsangi; L Diehl
Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis.
Gut 2008;57(10):1398-405.
2008: Charles W Lees; Janet Ironside; William A H Wallace; Jack Satsangi
Resolution of non-small-cell lung cancer after withdrawal of anti-TNF therapy.
The New England journal of medicine 2008;359(3):320-1.
2008: Charlie W Lees; Jack Satsangi
Early combined immunosuppression in Crohn's disease.
Lancet 2008;371(9629):1995; author reply 1996-7.
2008: Shahida Din; Anna Dahele; Janice Fennel; Sue Aitken; Alan G Shand; I D R Arnott; Jack Satsangi
Use of methotrexate in refractory Crohn's disease: the Edinburgh experience.
Inflammatory bowel diseases 2008;14(6):756-62.
2008: Jack Satsangi
Gene discovery in IBD: a decade of progress.
Journal of pediatric gastroenterology and nutrition 2008;46 Suppl 1():E1-2.
2008: Colin L Noble; J McCullough; W Ho; Charles W Lees; Elaine R Nimmo; Hazel E Drummond; S Bear; J Hannan; C Millar; S H Ralston; Jack Satsangi
Low body mass not vitamin D receptor polymorphisms predict osteoporosis in patients with inflammatory bowel disease.
Alimentary pharmacology & therapeutics 2008;27(7):588-96.
2008: Johan Van Limbergen; Richard K Russell; Elaine R Nimmo; Hazel E Drummond; Linda Smith; Niall H Anderson; G Davies; Peter M Gillett; Paraic McGrogan; Lawrence T Weaver; WM Bisset; Gamal Mahdi; I D R Arnott; David C Wilson; Jack Satsangi
Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood-onset in Crohn's disease in Northern Europe.
Inflammatory bowel diseases 2008;14(3):338-46.
2008: Gwo-Tzer Ho; Linda Smith; S Aitken; H M Lee; T Ting; Janice Fennell; Charles W Lees; Kelvin R Palmer; Ian D Penman; Alan G Shand; I D R Arnott; Jack Satsangi
The use of adalimumab in the management of refractory Crohn's disease.
Alimentary pharmacology & therapeutics 2008;27(4):308-15.
2008: Charles W Lees; A K Maan; B Hansoti; Jack Satsangi; I D R Arnott
Tolerability and safety of mercaptopurine in azathioprine-intolerant patients with inflammatory bowel disease.
Alimentary pharmacology & therapeutics 2008;27(3):220-7.
2008: S Din; C J Cochrane; Colin L Noble; Jack Satsangi; I D R Arnott
Combination therapy of infliximab and azathioprine reduces disease progression in Crohn's disease.
Inflammatory bowel diseases 2008;14(1):143-5.
2007: Johan Van Limbergen; Richard K Russell; Elaine R Nimmo; Jack Satsangi
The genetics of inflammatory bowel disease.
The American journal of gastroenterology 2007;102(12):2820-31.
2007: Johan Van Limbergen; Elaine R Nimmo; Richard K Russell; Hazel E Drummond; Linda Smith; Niall H Anderson; Gail Davies; I D R Arnott; David C Wilson; Jack Satsangi
Investigation of NOD1/CARD4 variation in inflammatory bowel disease using a haplotype-tagging strategy.
Human molecular genetics 2007;16(18):2175-86.
2007: Charles W Lees; D Heys; Gwo-Tzer Ho; Colin L Noble; Alan G Shand; Craig Mowat; R Boulton-Jones; A Williams; Nicholas I Church; Jack Satsangi; I D R Arnott
A retrospective analysis of the efficacy and safety of infliximab as rescue therapy in acute severe ulcerative colitis.
Alimentary pharmacology & therapeutics 2007;26(3):411-9.
2007: Johan Van Limbergen; Richard K Russell; Elaine R Nimmo; Hazel E Drummond; Linda Smith; G Davies; Niall H Anderson; Peter M Gillett; Paraic McGrogan; Kamal Hassan; L Weaver; WM Bisset; Gamal Mahdi; David C Wilson; Jack Satsangi
IL23R Arg381Gln is associated with childhood onset inflammatory bowel disease in Scotland.
Gut 2007;56(8):1173-4.
2007: Shahida Din; Anne Marie Lennon; I D R Arnott; Ted Hupp; Jack Satsangi
Technology insight: the application of proteomics in gastrointestinal disease.
Nature clinical practice. Gastroenterology & hepatology 2007;4(7):372-85.
2007: Johan Van Limbergen; Richard K Russell; Elaine R Nimmo; Leif Törkvist; Charles W Lees; Hazel E Drummond; Linda Smith; Niall H Anderson; Peter M Gillett; Paraic McGrogan; Kamal Hassan; Lawrence T Weaver; WM Bisset; Gamal Mahdi; I D R Arnott; Urban Sjöqvist; Mikael Lördal; Susan M Farrington; M G Dunlop; David C Wilson; Jack Satsangi
Contribution of the NOD1/CARD4 insertion/deletion polymorphism +32656 to inflammatory bowel disease in Northern Europe.
Inflammatory bowel diseases 2007;13(7):882-9.
2007: Mark Tremelling; Fraser Cummings; Sheila A Fisher; John Mansfield; Rhian Gwilliam; Andrew Keniry; Elaine R Nimmo; Hazel E Drummond; Clive M Onnie; Natalie Prescott; Jeremy Sanderson; Francesca Bredin; Carlo Berzuini; Alastair Forbes; Cathryn M Lewis; Lon Cardon; Panos Deloukas; Derek Jewell; Christopher G Mathew; Miles Parkes; Jack Satsangi
IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease.
Gastroenterology 2007;132(5):1657-64.
2007: Francesca Bresso; Johan Askling; Marco Astegiano; Brunello Demarchi; Nicoletta Sapone; Mario Rizzetto; Paolo Gionchetti; Karen Lammers; Annalisa de Leone; Gabriele Riegler; Elaine R Nimmo; Hazel E Drummond; Colin L Noble; Leif Torkvist; Anders Ekbom; Marco Zucchelli; Robert Lofberg; Jack Satsangi; Sven Pettersson; Mauro D'Amato
Potential role for the common cystic fibrosis DeltaF508 mutation in Crohn's disease.
Inflammatory bowel diseases 2007;13(5):531-6.
2007: Marian C Aldhous; Hazel E Drummond; Niall Anderson; M Reza Baneshi; Linda A Smith; I D R Arnott; Jack Satsangi
Smoking habit and load influence age at diagnosis and disease extent in ulcerative colitis.
The American journal of gastroenterology 2007;102(3):589-97.
2007: Marian C Aldhous; Hazel E Drummond; Niall Anderson; Linda A Smith; I D R Arnott; Jack Satsangi
Does cigarette smoking influence the phenotype of Crohn's disease? Analysis using the Montreal classification.
The American journal of gastroenterology 2007;102(3):577-88.
2007: Richard K Russell; Hazel E Drummond; Elaine R Nimmo; Niall Anderson; David C Wilson; Peter M Gillett; Paraic McGrogan; Kamal Hassan; Lawrence T Weaver; WM Bisset; Gamal Mahdi; Jack Satsangi
The contribution of the DLG5 113A variant in early-onset inflammatory bowel disease.
The Journal of pediatrics 2007;150(3):268-73.
2007: Johan Van Limbergen; Richard K Russell; Elaine R Nimmo; Gwo-Tzer Ho; I D R Arnott; David C Wilson; Jack Satsangi
Genetics of the innate immune response in inflammatory bowel disease.
Inflammatory bowel diseases 2007;13(3):338-55.
2007: Leif Törkvist; Colin L Noble; Mikael Lördal; Urban Sjöqvist; Ulrik Lindforss; Elaine R Nimmo; Robert Löfberg; Richard K Russell; Jack Satsangi
Contribution of the IBD5 locus to Crohn's disease in the Swedish population.
Scandinavian journal of gastroenterology 2007;42(2):200-6.
2006: Charles W Lees; Jack Satsangi
Hedgehog, paneth cells, and colon cancer: a cautionary note for the use of systemic agonists/antagonists.
Gastroenterology 2006;131(5):1657-8; author reply 1658.
2006: Gwo-Tzer Ho; Nicole Soranzo; Sarah K Tate; Hazel E Drummond; Elaine R Nimmo; Albert Tenesa; I D R Arnott; Jack Satsangi
Lack of association of the pregnane X receptor (PXR/NR1I2) gene with inflammatory bowel disease: parallel allelic association study and gene wide haplotype analysis.
Gut 2006;55(11):1676-7.
2006: Daniel R Gaya; S Aitken; Janice Fennell; Jack Satsangi; Alan G Shand
Anti-TNF-alpha therapy for orofacial granulomatosis: proceed with caution.
Gut 2006;55(10):1524-5.
2006: Richard K Russell; Hazel E Drummond; Elaine R Nimmo; Niall H Anderson; Colin L Noble; David C Wilson; Peter M Gillett; Paraic McGrogan; Kamal Hassan; Lawrence T Weaver; WM Bisset; Gamal Mahdi; Jack Satsangi
Analysis of the influence of OCTN1/2 variants within the IBD5 locus on disease susceptibility and growth indices in early onset inflammatory bowel disease.
Gut 2006;55(8):1114-23.
2006: Gwo-Tzer Ho; P Chiam; Hazel E Drummond; J Loane; I D R Arnott; Jack Satsangi
The efficacy of corticosteroid therapy in inflammatory bowel disease: analysis of a 5-year UK inception cohort.
Alimentary pharmacology & therapeutics 2006;24(2):319-30.
2006: Leif Törkvist; Colin L Noble; Mikael Lördal; Urban Sjöqvist; Ulrik Lindforss; Elaine R Nimmo; Richard K Russell; Robert Löfberg; Jack Satsangi
Contribution of CARD15 variants in determining susceptibility to Crohn's disease in Sweden.
Scandinavian journal of gastroenterology 2006;41(6):700-5.
2006: Jack Satsangi; M S Silverberg; S Vermeire; J-F Colombel
The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications.
Gut 2006;55(6):749-53.
2006: Daniel R Gaya; Richard K Russell; Elaine R Nimmo; Jack Satsangi
New genes in inflammatory bowel disease: lessons for complex diseases?
Lancet 2006;367(9518):1271-84.
2006: Colin L Noble; Elaine R Nimmo; Daniel R Gaya; Richard K Russell; Jack Satsangi
Novel susceptibility genes in inflammatory bowel disease.
World journal of gastroenterology : WJG 2006;12(13):1991-9.
2006: Charles W Lees; Alan G Shand; Ian D Penman; Jack Satsangi; I D R Arnott
Role of infliximab in ulcerative colitis: further questions.
Inflammatory bowel diseases 2006;12(4):335-7.
2006: Gwo-Tzer Ho; Nicole Soranzo; Elaine R Nimmo; Albert Tenesa; David B Goldstein; Jack Satsangi
ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach.
Human molecular genetics 2006;15(5):797-805.
2006: Albert Tenesa; Colin L Noble; Jack Satsangi; Malcolm Dunlop
Association of DLG5 and inflammatory bowel disease across populations.
European journal of human genetics : EJHG 2006;14(3):259-60; author reply 260-1.
2005: Colin L Noble; Elaine R Nimmo; Hazel E Drummond; Gwo-Tzer Ho; Albert Tenesa; Linda Smith; Norman Anderson; I D R Arnott; Jack Satsangi
The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease.
Gastroenterology 2005;129(6):1854-64.
2005: Gwo-Tzer Ho; Alexandra J Seddon; George Therapondos; Jack Satsangi; Peter C Hayes
The clinical course of ulcerative colitis after orthotopic liver transplantation for primary sclerosing cholangitis: further appraisal of immunosuppression post transplantation.
European journal of gastroenterology & hepatology 2005;17(12):1379-85.
2005: Charlie Lees; Sarah Howie; Ryan Sartor; Jack Satsangi
The hedgehog signalling pathway in the gastrointestinal tract: implications for development, homeostasis, and disease.
Gastroenterology 2005;129(5):1696-710.
2005: Gwo-Tzer Ho; Daniel R Gaya; Jack Satsangi
Multidrug resistance (MDR1) gene in inflammatory bowel disease: a key player?
Inflammatory bowel diseases 2005;11(11):1013-9.
2005: Richard K Russell; Hazel E Drummond; Elaine E Nimmo; Niall Anderson; Linda Smith; David C Wilson; Peter M Gillett; Paraic McGrogan; Kamal Hassan; Lawrence T Weaver; Michael Bisset; Gamal Mahdi; Jack Satsangi
Genotype-phenotype analysis in childhood-onset Crohn's disease: NOD2/CARD15 variants consistently predict phenotypic characteristics of severe disease.
Inflammatory bowel diseases 2005;11(11):955-64.
2005: Richard K Russell; R Farhadi; M Wilson; Hazel E Drummond; Jack Satsangi; David C Wilson
Perinatal passive smoke exposure may be more important than childhood exposure in the risk of developing childhood IBD.
Gut 2005;54(10):1500-1; author reply 1501.
2005: Colin L Noble; Elaine R Nimmo; Hazel E Drummond; Linda Smith; I D R Arnott; Jack Satsangi
DLG5 variants do not influence susceptibility to inflammatory bowel disease in the Scottish population.
Gut 2005;54(10):1416-20.
2005: Jack Satsangi; Harry Campbell; Malcolm G Dunlop; M E M Porteous
Molecular genetics in gastroenterology: from research success to clinical application?
Nature clinical practice. Gastroenterology & hepatology 2005;2(3):118-9.
2005: Gwo-Tzer Ho; Elaine R Nimmo; Albert Tenesa; Janice Fennell; Hazel E Drummond; Craig Mowat; I D R Arnott; Jack Satsangi
Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis.
Gastroenterology 2005;128(2):288-96.
2005: I D R Arnott; Gwo-Tzer Ho; Elaine R Nimmo; Jack Satsangi
Toll-like receptor 4 gene in IBD: further evidence for genetic heterogeneity in Europe.
Gut 2005;54(2):308; author reply 309.
2004: I D R Arnott; Carol J Landers; Elaine J Nimmo; Hazel E Drummond; Ben K R Smith; Stephan R Targan; Jack Satsangi
Sero-reactivity to microbial components in Crohn's disease is associated with disease severity and progression, but not NOD2/CARD15 genotype.
The American journal of gastroenterology 2004;99(12):2376-84.
2004: Emma L Armitage; Marian C Aldhous; Niall Anderson; Hazel E Drummond; Rudolph A Riemersma; Subrata Ghosh; Jack Satsangi
Incidence of juvenile-onset Crohn's disease in Scotland: association with northern latitude and affluence.
Gastroenterology 2004;127(4):1051-7.
2004: Richard K Russell; David C Wilson; Jack Satsangi
The frequency of CARD 15 mutations in the paediatric population.
Journal of pediatric gastroenterology and nutrition 2004;39(4):436.
2004: B R K Smith; I D R Arnott; Hazel E Drummond; Elaine R Nimmo; Jack Satsangi
Disease location, anti-Saccharomyces cerevisiae antibody, and NOD2/CARD15 genotype influence the progression of disease behavior in Crohn's disease.
Inflammatory bowel diseases 2004;10(5):521-8.
2004: Richard K Russell; David C Wilson; Jack Satsangi
CARD 15 / NOD 2 in paediatric onset Crohn's disease.
Journal of pediatric gastroenterology and nutrition 2004;39(2):216.
2004: I D R Arnott; Elaine R Nimmo; Hazel E Drummond; Janice Fennell; B R K Smith; E MacKinlay; J Morecroft; Niall Anderson; D Kelleher; M O'Sullivan; Ross McManus; Jack Satsangi
NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe?
Genes and immunity 2004;5(5):417-25.
2004: Richard K Russell; Jack Satsangi; David C Wilson
More pediatric NOD2/CARD data.
The American journal of gastroenterology 2004;99(7):1401; author reply 1402.
2004: Richard K Russell; David C Wilson; Jack Satsangi
Unravelling the complex genetics of inflammatory bowel disease.
Archives of disease in childhood 2004;89(7):598-603.
2004: Richard K Russell; Elaine R Nimmo; Jack Satsangi
Molecular genetics of Crohn's disease.
Current opinion in genetics & development 2004;14(3):264-70.
2004: Richard K Russell; Jack Satsangi
IBD: a family affair.
Best practice & research. Clinical gastroenterology 2004;18(3):525-39.
2004: Gwo-Tzer Ho; Craig Mowat; C J R Goddard; Janice Fennell; N B Shah; Robin J Prescott; Jack Satsangi
Predicting the outcome of severe ulcerative colitis: development of a novel risk score to aid early selection of patients for second-line medical therapy or surgery.
Alimentary pharmacology & therapeutics 2004;19(10):1079-87.
2004: Gwo-Tzer Ho; Charlie Lees; Jack Satsangi
Pharmacogenetics and inflammatory bowel disease: progress and prospects.
Inflammatory bowel diseases 2004;10(2):148-58.
2004: L J Walker; Marian C Aldhous; Hazel E Drummond; B R K Smith; Elaine R Nimmo; I D R Arnott; Jack Satsangi
Anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn's disease are associated with disease severity but not NOD2/CARD15 mutations.
Clinical and experimental immunology 2004;135(3):490-6.
2003: Simon Hellier; Angela J Frodsham; B J W Hennig; Paul Klenerman; Suzanne Knapp; Patricia A Ramaley; Jack Satsangi; Mark Wright; Lyna Zhang; Howard Thomas; Mark Thursz; Adrian V S Hill
Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection.
Hepatology (Baltimore, Md.) 2003;38(6):1468-76.
2003: Marian C Aldhous; Elaine R Nimmo; Jack Satsangi
NOD2/CARD15 and the Paneth cell: another piece in the genetic jigsaw of inflammatory bowel disease.
Gut 2003;52(11):1533-5.
2003: I D R Arnott; G McNeill; Jack Satsangi
An analysis of factors influencing short-term and sustained response to infliximab treatment for Crohn's disease.
Alimentary pharmacology & therapeutics 2003;17(12):1451-7.
2003: Gwo-Tzer Ho; F M Moodie; Jack Satsangi
Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease?
Gut 2003;52(5):759-66.
2003: I D R Arnott; Jack Satsangi
Crohn's disease or Crohn's diseases?
Gut 2003;52(4):460-1.
2003: Jack Satsangi; J Morecroft; N B Shah; Elaine R Nimmo
Genetics of inflammatory bowel disease: scientific and clinical implications.
Best practice & research. Clinical gastroenterology 2003;17(1):3-18.
2003: I D R Arnott; David Watts; Jack Satsangi
Azathioprine and anti-TNF alpha therapies in Crohn's disease: a review of pharmacology, clinical efficacy and safety.
Pharmacological research : the official journal of the Italian Pharmacological Society 2003;47(1):1-10.
2001: T Ahmad; Jack Satsangi; D McGovern; M Bunce; DP Jewell
Review article: the genetics of inflammatory bowel disease.
Alimentary pharmacology & therapeutics 2001;15(6):731-48.
2001: Gillian Harcourt; Simon Hellier; Mike Bunce; Jack Satsangi; J Collier; R Chapman; Rodney Phillips; Paul Klenerman
Effect of HLA class II genotype on T helper lymphocyte responses and viral control in hepatitis C virus infection.
Journal of viral hepatitis 2001;8(3):174-9.
2001: Severine Vermeire; Jack Satsangi; M Peeters; Miles Parkes; D P Jewell; Robert Francois Vlietinck; Paul Rutgeerts
Evidence for inflammatory bowel disease of a susceptibility locus on the X chromosome.
Gastroenterology 2001;120(4):834-40.
2000: Severine Vermeire; M Peeters; Robert Francois Vlietinck; Miles Parkes; Jack Satsangi; Derek Jewell; Paul Rutgeerts
Exclusion of linkage of Crohn's disease to previously reported regions on chromosomes 12, 7, and 3 in the Belgian population indicates genetic heterogeneity.
Inflammatory bowel diseases 2000;6(3):165-70.
2000: David A van Heel; Jack Satsangi; Alisoun Carey; Derek P Jewell
Inflammatory bowel disease: progress toward a gene.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie 2000;14(3):207-18.
2000: K Koss; Jack Satsangi; KI Welsh; DP Jewell
Is interleukin-6 important in inflammatory bowel disease?
Genes and immunity 2000;1(3):207-12.
2000: K Koss; Jack Satsangi; GC Fanning; KI Welsh; DP Jewell
Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies.
Genes and immunity 2000;1(3):185-90.
1999: K Kyo; Miles Parkes; Y Takei; H Nishimori; P Vyas; Jack Satsangi; J Simmons; H Nagawa; S Baba; Derek Jewell; T Muto; G M Lathrop; Yusuke Nakamura
Association of ulcerative colitis with rare VNTR alleles of the human intestinal mucin gene, MUC3.
Human molecular genetics 1999;8(2):307-11.
1998: Jack Satsangi; Miles Parkes; DP Jewell
Molecular genetics of Crohn's disease: recent advances.
The European journal of surgery = Acta chirurgica 1998;164(12):887-91.
1998: Jack Satsangi; Derek Jewell; Miles Parkes; J Bell
Genetics of inflammatory bowel disease. A personal view on progress and prospects.
Digestive diseases (Basel, Switzerland) 1998;16(6):370-4.
1998: Miles Parkes; Jack Satsangi; Derek Jewell
Contribution of the IL-2 and IL-10 genes to inflammatory bowel disease (IBD) susceptibility.
Clinical and experimental immunology 1998;113(1):28-32.
1998: Jack Satsangi; Miles Parkes; DP Jewell; J I Bell
Genetics of inflammatory bowel disease.
Clinical science (London, England : 1979) 1998;94(5):473-8.
1998: Jack Satsangi; Carol J Landers; KI Welsh; K Koss; S Targan; DP Jewell
The presence of anti-neutrophil antibodies reflects clinical and genetic heterogeneity within inflammatory bowel disease.
Inflammatory bowel diseases 1998;4(1):18-26.
1997: Miles Parkes; Jack Satsangi; Derek Jewell
Mapping susceptibility loci in inflammatory bowel disease: why and how?
Molecular medicine today 1997;3(12):546-53.
1997: M Roussomoustakaki; Jack Satsangi; K Welsh; E Louis; GC Fanning; S Targan; Carol J Landers; DP Jewell
Genetic markers may predict disease behavior in patients with ulcerative colitis.
Gastroenterology 1997;112(6):1845-53.
1996: Miles Parkes; Jack Satsangi; G M Lathrop; John I Bell; D P Jewell
Susceptibility loci in inflammatory bowel disease.
Lancet 1996;348(9041):1588.
1996: E Louis; Jack Satsangi; M Roussomoustakaki; Miles Parkes; G Fanning; K Welsh; Derek Jewell
Cytokine gene polymorphisms in inflammatory bowel disease.
Gut 1996;39(5):705-10.
1996: Jack Satsangi; Miles Parkes; E Louis; L Hashimoto; N Kato; K Welsh; Joseph D Terwilliger; G M Lathrop; John I Bell; D P Jewell
Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12.
Nature genetics 1996;14(2):199-202.
1996: philip hayward; Jack Satsangi; D P Jewell
Inflammatory bowel disease and the X chromosome.
QJM : monthly journal of the Association of Physicians 1996;89(9):713-8.
1996: Jack Satsangi; Miles Parkes; D P Jewell
Genetics of ulcerative colitis.
Lancet 1996;348(9027):624-5.
1996: Jack Satsangi; K I Welsh; Mike Bunce; C Julier; J M Farrant; John I Bell; D P Jewell
Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease.
Lancet 1996;347(9010):1212-7.
1996: Jack Satsangi; C Grootscholten; H Holt; D P Jewell
Clinical patterns of familial inflammatory bowel disease.
Gut 1996;38(5):738-41.
1996: Jack Satsangi; D P Jewell
Are cytokine gene polymorphisms important in the pathogenesis of inflammatory bowel disease?
European journal of gastroenterology & hepatology 1996;8(2):97-9.
1996: Jack Satsangi; J Marshall; D Roskell; Derek Jewell
Ulcerative colitis complicated by renal cell carcinoma: a series of three patients.
Gut 1996;38(1):148-50.
1995: D C Rees; Jack Satsangi; piers cornelissen; S P Travis; J White; D P Jewell
Are serum concentrations of nitric oxide metabolites useful for predicting the clinical outcome of severe ulcerative colitis?
European journal of gastroenterology & hepatology 1995;7(3):227-30.
1995: Jack Satsangi; D Rees; D Jewell
Nitric oxide in ulcerative colitis.
Lancet 1995;345(8947):448-9.
1994: Jack Satsangi; D P Jewell; K Welsh; M Bunce; John I Bell
Effect of heparin on polymerase chain reaction.
Lancet 1994;343(8911):1509-10.