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Isabel Sattler

Research Profile

Chemicals & Drugs

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Genes & Molecular Sequences

Molecular Structure

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Magnetic Resonance Spectroscopy

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Drug Screening Assays, Antitumor

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Publications

TOP 3
Basile Le S Tchize Ndejouong; Isabel Sattler; Armin Maier; Gerhard Kelter; Klaus-Dieter Menzel; Heinz-Herbert Fiebig; Christian Hertweck
Hygrobafilomycin, a cytotoxic and antifungal macrolide bearing a unique monoalkylmaleic anhydride moiety, from Streptomyces varsoviensis.
Fangfang Wang; Minjuan Xu; Qingshan Li; Isabel Sattler; Wenhan Lin
p-Aminoacetophenonic acids produced by a mangrove endophyte Streptomyces sp. (strain HK10552).
Randa Abdou; Kirstin Scherlach; Hans-Martin Dahse; Isabel Sattler; Christian Hertweck
Botryorhodines A-D, antifungal and cytotoxic depsidones from Botryosphaeria rhodina, an endophyte of the medicinal plant Bidens pilosa.

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All Publications

2010: Basile Le S Tchize Ndejouong; Isabel Sattler; Armin Maier; Gerhard Kelter; Klaus-Dieter Menzel; Heinz-Herbert Fiebig; Christian Hertweck
Hygrobafilomycin, a cytotoxic and antifungal macrolide bearing a unique monoalkylmaleic anhydride moiety, from Streptomyces varsoviensis.
The Journal of antibiotics 2010;63(7):359-63.
2010: Fangfang Wang; Minjuan Xu; Qingshan Li; Isabel Sattler; Wenhan Lin
p-Aminoacetophenonic acids produced by a mangrove endophyte Streptomyces sp. (strain HK10552).
Molecules (Basel, Switzerland) 2010;15(4):2782-90.
2010: Randa Abdou; Kirstin Scherlach; Hans-Martin Dahse; Isabel Sattler; Christian Hertweck
Botryorhodines A-D, antifungal and cytotoxic depsidones from Botryosphaeria rhodina, an endophyte of the medicinal plant Bidens pilosa.
Phytochemistry 2010;71(1):110-6.
2009: B Le S Tchize Ndejouong; Isabel Sattler; Hans-Martin Dahse; E Kothe; Christian Hertweck
Isoflavones with unusually modified B-rings and their evaluation as antiproliferative agents.
Bioorganic & medicinal chemistry letters 2009;19(22):6473-6.
2008: Li-Ya Li; Yi Ding; Ingrid Groth; Klaus-Dieter Menzel; Gundela Peschel; Kerstin Voigt; Zhi-Wei Deng; Isabel Sattler; Wen-Han Lin
Pyrrole and indole alkaloids from an endophytic Fusarium incarnatum (HKI00504) isolated from the mangrove plant Aegiceras corniculatum.
Journal of Asian natural products research 2008;10(7-8):775-80.
2008: Xuemei Niu; Hans-Martin Dahse; Klaus-Dieter Menzel; Olivier Lozach; Grit Walther; Laurent Meijer; Susanne Grabley; Isabel Sattler
Butyrolactone I derivatives from Aspergillus terreus carrying an unusual sulfate moiety.
Journal of natural products 2008;71(4):689-92.
2008: Li Han; Xueshi Huang; Hans-Martin Dahse; Ute Moellmann; Susanne Grabley; Wenhan Lin; Isabel Sattler
New abietane diterpenoids from the mangrove Avicennia marina.
Planta medica 2008;74(4):432-7.
2008: Xueshi Huang; Jian He; Xuemei Niu; Klaus-Dieter Menzel; Hans-Martin Dahse; Susanne Grabley; Hans-Peter Fiedler; Isabel Sattler; Christian Hertweck
Benzopyrenomycin, a cytotoxic bacterial polyketide metabolite with a benzo[a]pyrene-type carbocyclic ring system.
Angewandte Chemie (International ed. in English) 2008;47(21):3995-8.
2008: Liya Li; Isabel Sattler; Zhiwei Deng; Ingrid Groth; Grit Walther; Gudrun Peschel; Susanne Grabley; Wenhan Lin
A-seco-oleane-type triterpenes from Phomopsis sp. (strain HKI0458) isolated from the mangrove plant Hibiscus tiliaceus.
Phytochemistry 2008;69(2):511-7.
2007: Jian He; Ernst Roemer; Corinna Lange; Xueshi Huang; Armin Maier; Gerhard Kelter; Yi Jiang; Li-Hua Xu; Klaus-Dieter Menzel; Susanne Grabley; Heinz-Herbert Fiebig; Cheng-Ling Jiang; Isabel Sattler
Structure, derivatization, and antitumor activity of new griseusins from Nocardiopsis sp.
Journal of medicinal chemistry 2007;50(21):5168-75.
2007: Xue-Mei Niu; Sheng-Hong Li; Helmar Görls; Dieter Schollmeyer; Matthias Hilliger; Susanne Grabley; Isabel Sattler
Abyssomicin E, a highly functionalized polycyclic metabolite from Streptomyces species.
Organic letters 2007;9(13):2437-40.
2007: Li Han; Xueshi Huang; Hans-Martin Dahse; Ute Moellmann; Hongzheng Fu; Susanne Grabley; Isabel Sattler; Wenhan Lin
Unusual naphthoquinone derivatives from the twigs of Avicennia marina.
Journal of natural products 2007;70(6):923-7.
2007: L Han; X-S Huang; Isabel Sattler; H-Z Fu; Susanne Grabley; W-H Lin
Two new constituents from mangrove Bruguiera gymnorrhiza.
Journal of Asian natural products research 2007;9(3-5):327-31.
2007: Xiang Li; Isabel Sattler; Wenhan Lin
Penisporolides A and B, two new spiral lactones from the marine-derived fungus Penicillium sp.
The Journal of antibiotics 2007;60(3):191-5.
2007: J E Angeh; X Huang; Isabel Sattler; Gerry E Swan; Hans-Martin Dahse; Albert Härtl; Jacobus Eloff
Antimicrobial and anti-inflammatory activity of four known and one new triterpenoid from Combretum imberbe (Combretaceae).
Journal of ethnopharmacology 2007;110(1):56-60.
2006: Liya Li; Xueshi Huang; Isabel Sattler; Hongzheng Fu; Susanne Grabley; Wenhan Lin
Structure elucidation of a new friedelane triterpene from the mangrove plant Hibiscus tiliaceus.
Magnetic resonance in chemistry : MRC 2006;44(6):624-8.
2006: Xueshi Huang; Ernst Roemer; Isabel Sattler; Ute Moellmann; Arnulf Christner; Susanne Grabley
Lydiamycins A-D: cyclodepsipetides with antimycobacterial properties.
Angewandte Chemie (International ed. in English) 2006;45(19):3067-72.
2005: Shuhong Guan; Susanne Grabley; Ingrid Groth; Wenhan Lin; Arnulf Christner; Dean Guo; Isabel Sattler
Structure determination of germacrane-type sesquiterpene alcohols from an endophyte Streptomyces griseus subsp.
Magnetic resonance in chemistry : MRC 2005;43(12):1028-31.
2005: Wenhan Lin; Liya Li; Hongzheng Fu; Isabel Sattler; Xueshi Huang; Susanne Grabley
New cyclopentenone derivatives from an endophytic Streptomyces sp. isolated from the mangrove plant Aegiceras comiculatum.
The Journal of antibiotics 2005;58(9):594-8.
2005: Li Han; Xueshi Huang; Isabel Sattler; Hans-Martin Dahse; Hongzheng Fu; Susanne Grabley; Wenhan Lin
Three new pimaren diterpenoids from marine mangrove plant, Bruguiera gymnorrhiza.
Die Pharmazie 2005;60(9):705-7.
2005: Jian He; Ulrich Lion; Isabel Sattler; Friedrich A Gollmick; Susanne Grabley; Jingmin Cai; Marinus Meiners; Henning Schünke; Karsten Schaumann; Ute Dechert; Michael Krohn
Diastereomeric quinolinone alkaloids from the marine-derived fungus Penicillium janczewskii.
Journal of natural products 2005;68(9):1397-9.
2005: Shu-Hong Guan; Isabel Sattler; Wen-Han Lin; De-An Guo; Susanne Grabley
p-Aminoacetophenonic acids produced by a mangrove endophyte: Streptomyces griseus subsp.
Journal of natural products 2005;68(8):1198-200.
2005: Fuchao Li; Rajendra P Maskey; Song Qin; Isabel Sattler; Heinz-Herbert Fiebig; Armin Maier; Axel Zeeck; Hartmut Laatsch
Chinikomycins A and B: isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp. isolate M045.
Journal of natural products 2005;68(3):349-53.
2005: Li Han; Xueshi Huang; Isabel Sattler; Ute Moellmann; Hongzheng Fu; Wenhan Lin; Susanne Grabley
New aromatic compounds from the marine mangrove Bruguiera gymnorrhiza.
Planta medica 2005;71(2):160-4.
2005: Andreas Mitsch; Mirko Altenkämper; Isabel Sattler; Martin Schlitzer
Non-thiol farnesyltransferase inhibitors: utilization of the far aryl binding site by arylthienylacryloylaminobenzophenones.
Archiv der Pharmazie 2005;338(1):9-17.
2005: Katja Kettler; Jochen Wiesner; Katrin Silber; Peter Haebel; Regina Ortmann; Isabel Sattler; Hans-Martin Dahse; Hassan Jomaa; Gerhard Klebe; Martin Schlitzer
Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl]acrylic acid amides and their antimalarial activity.
European journal of medicinal chemistry 2005;40(1):93-101.
2004: Li Han; Xueshi Huang; Isabel Sattler; Hans-Martin Dahse; Hongzheng Fu; Wenhan Lin; Susanne Grabley
New diterpenoids from the marine mangrove Bruguiera gymnorrhiza.
Journal of natural products 2004;67(9):1620-3.
2004: Andreas Mitsch; Pia Wissner; Markus Böhm; Katrin Silber; Gerhard Klebe; Isabel Sattler; Martin Schlitzer
Non-thiol farnesyltransferase inhibitors: utilization of the far aryl binding site by 5-cinnamoylaminobenzophenones.
Archiv der Pharmazie 2004;337(9):493-501.
2004: Andreas Mitsch; Pia Wissner; Katrin Silber; Peter Haebel; Isabel Sattler; Gerhard Klebe; Martin Schlitzer
Non-thiol farnesyltransferase inhibitors: N-(4-tolylacetylamino-3-benzoylphenyl)-3-arylfurylacrylic acid amides.
Bioorganic & medicinal chemistry 2004;12(17):4585-600.
2004: Andreas Mitsch; Markus Böhm; Isabel Sattler; Martin Schlitzer
Non-thiol farnesyltransferase inhibitors: utilization of the near aryl binding site by 5-arylacetylaminobenzophenones.
Archiv der Pharmazie 2004;337(4):213-8.
2003: Jin-Feng Hu; Dirk Wunderlich; Isabel Sattler; Ralf Thiericke; Susanne Grabley; Xiao-Zhang Feng
New 2-o-methylrhamno-isoflavones from Streptomyces sp.
Natural product research 2003;17(6):451-8.
2003: Jin-Feng Hu; Dirk Wunderlich; Ralf Thiericke; Hans-Martin Dahse; Susanne Grabley; Xiao-Zhang Feng; Isabel Sattler
Jenamidines A to C: unusual alkaloids from Streptomyces sp. with specific antiproliferative properties obtained by chemical screening.
The Journal of antibiotics 2003;56(9):747-54.
2003: Minggang Li; Ingrid Groth; Yiqing Li; Isabel Sattler; Mengliang Wen
[The secondary metabolites research of the alkalophlic strain YIMGQ14 tracked by the TLC assay].
Wei sheng wu xue bao = Acta microbiologica Sinica 2003;43(4):481-6.
2003: Andreas Mitsch; Silke Bergemann; Ronald Gust; Isabel Sattler; Martin Schlitzer
Non-thiol farnesyltransferase inhibitors: FTase-inhibition and cellular activity of benzophenone-based bisubstrate analogue farnesyltransferase inhibitors.
Archiv der Pharmazie 2003;336(4-5):242-50.
2003: Katja Kettler; Jacek Sakowski; Katrin Silber; Isabel Sattler; Gerhard Klebe; Martin Schlitzer
Non-thiol farnesyltransferase inhibitors: N-(4-acylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides.
Bioorganic & medicinal chemistry 2003;11(7):1521-30.
2003: Jochen Wiesner; Regina Ortmann; Andreas Mitsch; Pia Wissner; Isabel Sattler; Hassan Jomaa; Martin Schlitzer
Inhibitors of farnesyltransferase: 5-arylacryloylaminobenzophenones show antimalarial activity.
Die Pharmazie 2003;58(4):289-90.
2003: Susanne Grabley; Isabel Sattler
Natural products for lead identification: nature is a valuable resource for providing tools.
EXS 2003;(93):87-107.
2002: Andreas Mitsch; Markus Böhm; Pia Wissner; Isabel Sattler; Martin Schlitzer
Non-thiol farnesyltransferase inhibitors: utilization of an aryl binding site by 5-arylacryloylaminobenzophenones.
Bioorganic & medicinal chemistry 2002;10(8):2657-62.
2002: Jacek Sakowski; Markus Böhm; Isabel Sattler; Martin Schlitzer
Non-thiol farnesyltransferase inhibitors: evaluation of different AA(X)-peptidomimetic substructures in combination with arylic cysteine replacements.
Archiv der Pharmazie 2002;335(4):135-42.
2002: Martin Schlitzer; Markus Böhm; Isabel Sattler
Non-thiol farnesyltransferase inhibitors: structure-activity relationships of benzophenone-based bisubstrate analogue farnesyltransferase inhibitors.
Bioorganic & medicinal chemistry 2002;10(3):615-20.
2002: Jacek Sakowski; Isabel Sattler; Martin Schlitzer
Non-thiol farnesyltransferase inhibitors: N-(4-Acylamino-3-benzoylphenyl)-4-nitrocinnamic acid amides.
Bioorganic & medicinal chemistry 2002;10(2):233-9.
2001: Markus Böhm; Andreas Mitsch; Pia Wissner; Isabel Sattler; Martin Schlitzer
Exploration of novel aryl binding sites of farnesyltransferase using molecular modeling and benzophenone-based farnesyltransferase inhibitors.
Journal of medicinal chemistry 2001;44(19):3117-24.
2001: Jacek Sakowski; Markus Böhm; Isabel Sattler; Hans-Martin Dahse; Martin Schlitzer
Synthesis, molecular modeling, and structure-activity relationship of benzophenone-based CAAX-peptidomimetic farnesyltransferase inhibitors.
Journal of medicinal chemistry 2001;44(18):2886-99.
2001: Andreas Mitsch; Pia Wissner; Isabel Sattler; Martin Schlitzer
Non-thiol farnesyltransferase inhibitors: structure-activity relationships of aralkylsubstituted benzophenones.
Archiv der Pharmazie 2001;334(2):40-4.
2000: Martin Schlitzer; Markus Böhm; Isabel Sattler
Non-peptidic, non-prenylic bisubstrate farnesyltransferase inhibitors. Part 3: structural requirements of the central moiety for farnesyltransferase inhibitory activity.
Bioorganic & medicinal chemistry 2000;8(10):2399-406.
2000: Jin-Feng Hu; Dirk Wunderlich; Isabel Sattler; Albert Härtl; I Papastavrou; Stephanie Grond; Susanne Grabley; Xiao-Zhang Feng; Ralf Thiericke
New 1-O-acyl alpha-L-rhamnopyranosides and rhamnosylated lactones from Streptomyces sp., inhibitors of 3 alpha-hydroxysteroid-dehydrogenase (3alpha-HSD).
The Journal of antibiotics 2000;53(9):944-53.
2000: Y Q Tang; Isabel Sattler; Ralf Thiericke; Susanne Grabley; Xiao-Zhang Feng
Feigrisolides A, B, C and D, new lactones with antibacterial activities from Streptomyces griseus.
The Journal of antibiotics 2000;53(9):934-43.
2000: Martin Schlitzer; Markus Böhm; Isabel Sattler; Hans-Martin Dahse
Design, synthesis and early structure-activity relationship of farnesyltransferase inhibitors which mimic both the peptidic and the prenylic substrate.
Bioorganic & medicinal chemistry 2000;8(8):1991-2006.
2000: Martin Schlitzer; Isabel Sattler
Non-thiol farnesyltransferase inhibitors: the concept of benzophenone-based bisubstrate analogue farnesyltransferase inhibitors.
European journal of medicinal chemistry 2000;35(7-8):721-6.
2000: Martin Schlitzer; Isabel Sattler; A Friese; Ilse Zündorf; T Dingermann
Synthesis of 4-(acylaminomethyl)benzamides and their evaluation as potential anticancer agents.
Anticancer research 2000;20(3A):1723-6.
2000: Susanne Grabley; Ralf Thiericke; Isabel Sattler
Tools for drug discovery: natural product-based libraries.
Ernst Schering Research Foundation workshop 2000;(32):217-52.
1999: C Maul; Isabel Sattler; Marion Zerlin; C Hinze; C Koch; A Maier; Susanne Grabley; Ralf Thiericke
Biomolecular-chemical screening: a novel screening approach for the discovery of biologically active secondary metabolites. III. New DNA-binding metabolites.
The Journal of antibiotics 1999;52(12):1124-34.
1999: A Maier; C Maul; Marion Zerlin; Isabel Sattler; Susanne Grabley; Ralf Thiericke
Biomolecular-chemical screening: a novel screening approach for the discovery of biologically active secondary metabolites. I. Screening strategy and validation.
The Journal of antibiotics 1999;52(11):945-51.
1999: Martin Schlitzer; Isabel Sattler
Aromatic carboxylic acids as farnesyl surrogates in farnesylpyrophosphate-based farnesyltransferase inhibitors.
Bioorganic & medicinal chemistry 1999;7(11):2391-5.
1999: Martin Schlitzer; Isabel Sattler; Hans-Martin Dahse
Synthesis and evaluation of homofarnesoyl-substituted CAAX-peptidomimetics as farnesyltransferase inhibitors and antiproliferative agents.
Bioorganic & medicinal chemistry 1999;7(9):2037-45.
1999: Martin Schlitzer; Isabel Sattler; Hans-Martin Dahse
Synthesis and antiproliferative activity of N-acylaspartic acid dimethyl esters.
Anticancer research 1999;19(3A):2117-20.
1999: Martin Schlitzer; Isabel Sattler; Hans-Martin Dahse
Different amino acid replacements in CAAX-tetrapeptide based peptidomimetic farnesyltransferase inhibitors.
Archiv der Pharmazie 1999;332(4):124-32.
1998: Isabel Sattler; Ralf Thiericke; Axel Zeeck
The manumycin-group metabolites.
Natural product reports 1998;15(3):221-40.
1994: O Dick; U Onken; Isabel Sattler; Axel Zeeck
Influence of increased dissolved oxygen concentration on productivity and selectivity in cultures of a colabomycin-producing strain of Streptomyces griseoflavus.
Applied microbiology and biotechnology 1994;41(4):373-7.
1994: D Kaiser; U Onken; Isabel Sattler; Axel Zeeck
Influence of increased dissolved oxygen concentration on the formation of secondary metabolites by manumycin-producing Streptomyces parvulus.
Applied microbiology and biotechnology 1994;41(3):309-12.