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Frédéric Saudou

Research Profile

Disorders

Huntington's Disease

Chemicals & Drugs

Anatomy

Living Beings

Physiology

Phenomena

Phosphorylation

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Publications

TOP 3
Karim Ben M'barek; Caroline Benstaali; Denis J David; Alain M Gardier; Juliette D Godin; Sophie Orvoen; Patrick Pla; Frédéric Saudou; Sandrine Humbert
Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.
Géraldine Liot; Guillaume Mottet; Matthieu Piel; Patrick Pla; Diana Zala; Frédéric Saudou
Mutant Huntingtin Alters Retrograde Transport of TrkB Receptors in Striatal Dendrites.
Diana Zala; Hua Yu; Fabrice P Cordelières; Maria-Victoria Hinckelmann; Géraldine Liot; Marcel Menezes Lyra da Cunha; Sergio Marco; Frédéric Saudou
Vesicular glycolysis provides on-board energy for fast axonal transport.

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All Publications

2013: Karim Ben M'barek; Caroline Benstaali; Denis J David; Alain M Gardier; Juliette D Godin; Sophie Orvoen; Patrick Pla; Frédéric Saudou; Sandrine Humbert
Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(20):8608-20.
2013: Géraldine Liot; Guillaume Mottet; Matthieu Piel; Patrick Pla; Diana Zala; Frédéric Saudou
Mutant Huntingtin Alters Retrograde Transport of TrkB Receptors in Striatal Dendrites.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(15):6298-309.
2013: Diana Zala; Hua Yu; Fabrice P Cordelières; Maria-Victoria Hinckelmann; Géraldine Liot; Marcel Menezes Lyra da Cunha; Sergio Marco; Frédéric Saudou
Vesicular glycolysis provides on-board energy for fast axonal transport.
Cell 2013;152(3):479-91.
2013: Diana Zala; Maria-Victoria Hinckelmann; Frédéric Saudou
Huntingtin's Function in Axonal Transport Is Conserved in Drosophila melanogaster.
PloS one 2013;8(3):e60162.
2012: Frédéric Saudou
A "so cilia" network: cilia proteins start "social" networking.
The Journal of clinical investigation 2012;122(4):1198-202.
2012: Jean Christophe ROUX; Frédéric Saudou; Ana Borges-Correia; Nicolas Panayotis; Diana Zala; Laurent Villard
Modification of Mecp2 dosage alters axonal transport through the Huntingtin/Hap1 pathway.
Neurobiology of disease 2012;45(2):786-95.
2012: Jean Christophe ROUX; Frédéric Saudou; Ana Borges-Correia; Nicolas Panayotis; Diana Zala; Laurent Villard
[Unexpected link between Huntington disease and Rett syndrome].
Médecine sciences : M/S 2012;28(1):44-6.
2011: Jason Miller; Emily J Mitchell; Siddhartha Mitra; Paul J Muchowski; Yvonne Newhouse; Alex Osmand; Frédéric Saudou; Mark Segal; Benjamin A Shaby; Leslie M Thompson; Vanitha Thulasiramin; Karl H Weisgraber; Kartika Widjaja; X William Yang; Montserrat Arrasate; Elizabeth Brooks; Kenneth Cheung; Jessica Curtis; Michelle Gray; Danny Hatters; Preethi Krishnan; Justin Legleiter; Clare Peters Libeu; Gregor P Lotz; Eliezer Masliah; Steven Finkbeiner
Identifying polyglutamine protein species in situ that best predict neurodegeneration.
Nature chemical biology 2011;7(12):925-34.
2011: Guy Keryer; Jinho Kim; Géraldine Liot; Jose R Pineda; Caroline Benstaali; Fabrice P Cordelières; Paula Dietrich; Ioannis Dragatsis; Robert J Ferrante; Karen Smith; Nathalie Spassky; Frédéric Saudou
Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.
The Journal of clinical investigation 2011;121(11):4372-82.
2011: Catherine Marquer; Viviane Devauges; Jack-Christophe Cossec; Géraldine Liot; Sandrine Lécart; Frédéric Saudou; Charles Duyckaerts; Sandrine Lévêque-Fort; Marie-Claude Potier
Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(4):1295-305.
2010: Daniel del Toro; Xavier Xifró; Albert Pol; Sandrine Humbert; Frédéric Saudou; Josep M Canals; Jordi Alberch
Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease.
Journal of neurochemistry 2010;115(1):153-67.
2010: Juliette D Godin; Kelly Colombo; Maria Molina-Calavita; Guy Keryer; Diana Zala; Bénédicte C Charrin; Paula Dietrich; Marie-Laure Volvert; François Guillemot; Ioannis Dragatsis; Yohanns Bellaiche; Frédéric Saudou; Laurent Nguyen; Sandrine Humbert
Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis.
Neuron 2010;67(3):392-406.
2010: Raúl Pardo; Maria Molina-Calavita; Ghislaine Poizat; Guy Keryer; Sandrine Humbert; Frédéric Saudou
pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking.
Molecular brain 2010;3():17.
2010: Laurent Nguyen; Sandrine Humbert; Frédéric Saudou; Alain Chariot
Elongator - an emerging role in neurological disorders.
Trends in molecular medicine 2010;16(1):1-6.
2009: Anja W Fjorback; Patrick Pla; Heidi K Müller; Ove Wiborg; Frédéric Saudou; Jens R Nyengaard
Serotonin transporter oligomerization documented in RN46A cells and neurons by sensitized acceptor emission FRET and fluorescence lifetime imaging microscopy.
Biochemical and biophysical research communications 2009;380(4):724-8.
2009: Jose R Pineda; Raúl Pardo; Diana Zala; Hua Yu; Sandrine Humbert; Frédéric Saudou
Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease.
Molecular brain 2009;2():33.
2008: Diana Zala; Emilie Colin; Hélène Rangone; Géraldine Liot; Sandrine Humbert; Frédéric Saudou
Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.
Human molecular genetics 2008;17(24):3837-46.
2008: emilie colin; Diana Zala; Géraldine Liot; Hélène Rangone; Maria Borrell-Pagès; Xiao-Jiang Li; Frédéric Saudou; Sandrine Humbert
Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons.
The EMBO journal 2008;27(15):2124-34.
2008: Emmanuel Roze; Frédéric Saudou; Jocelyne Caboche
Pathophysiology of Huntington's disease: from huntingtin functions to potential treatments.
Current opinion in neurology 2008;21(4):497-503.
2008: Frédéric Saudou; Sandrine Humbert
The biology of Huntington's disease.
Handbook of clinical neurology 2008;89():619-29.
2007: Sandrine L Anne; Frédéric Saudou; Sandrine Humbert
Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(27):7318-28.
2007: Jim P Dompierre; Juliette godin; Bénédicte Charrin; Fabrice P Cordelières; Stephen J King; Sandrine Humbert; Frédéric Saudou
Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(13):3571-83.
2006: Frédéric Saudou; Sandrine Humbert
[Cysteamine restores intracellular dynamics and BDNF secretion in Huntington's disease].
Médecine sciences : M/S 2006;22(11):906-8.
2006: Maria Borrell-Pagès; Diana Zala; Sandrine Humbert; Frédéric Saudou
Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.
Cellular and molecular life sciences : CMLS 2006;63(22):2642-60.
2006: Sandrine Humbert; Frédéric Saudou
The ataxia-ome: connecting disease proteins of the cerebellum.
Cell 2006;125(4):645-7.
2006: Maria Borrell-Pagès; Josep M Canals; Fabrice P Cordelières; Alex Parker; Jose R Pineda; Ghislaine Grange; Elzbieta A Bryson; Martine Guillermier; Etienne C Hirsch; Philippe Hantraye; Michael Cheetham; Christian Néri; Jordi Alberch; Emmanuel Brouillet; Frédéric Saudou; Sandrine Humbert
Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.
The Journal of clinical investigation 2006;116(5):1410-24.
2006: Alexandra Benchoua; Yaël Trioulier; Diana Zala; Marie-Claude Gaillard; Nathalie Lefort; Noelle Dufour; Frédéric Saudou; Jean-Marc Elalouf; Etienne C Hirsch; Philippe Hantraye; Nicole Deglon; Emmanuel Brouillet
Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin.
Molecular biology of the cell 2006;17(4):1652-63.
2006: Raúl Pardo; emilie colin; Etienne Régulier; Patrick Aebischer; Nicole Deglon; Sandrine Humbert; Frédéric Saudou
Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(5):1635-45.
2005: Hélène Rangone; Raúl Pardo; emilie colin; Jean-Antoine Girault; Frédéric Saudou; Sandrine Humbert
Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment.
The Journal of biological chemistry 2005;280(23):22021-8.
2005: Bénédicte Charrin; Frédéric Saudou; Sandrine Humbert
Axonal transport failure in neurodegenerative disorders: the case of Huntington's disease.
Pathologie-biologie 2005;53(4):189-92.
2005: emilie colin; Etienne Régulier; Valérie Perrin; Alexandra Dürr; Alexis Brice; Patrick Aebischer; Nicole Deglon; Sandrine Humbert; Frédéric Saudou
Akt is altered in an animal model of Huntington's disease and in patients.
The European journal of neuroscience 2005;21(6):1478-88.
2005: Sandrine Humbert; Frédéric Saudou
[Huntington's disease: intracellular signaling pathways and neuronal death].
Journal de la Société de biologie 2005;199(3):247-51.
2004: Sandrine Humbert; Frédéric Saudou
[Stimulation of BDNF transport by huntingtin].
Médecine sciences : M/S 2004;20(11):952-4.
2004: Laurent Gauthier; Bénédicte Charrin; Maria Borrell-Pagès; Jim P Dompierre; Hélène Rangone; Fabrice P Cordelières; Jan De Mey; Marcy E MacDonald; Volkmar Lessmann; Sandrine Humbert; Frédéric Saudou
Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules.
Cell 2004;118(1):127-38.
2004: Hélène Rangone; Sandrine Humbert; Frédéric Saudou
Huntington's disease: how does huntingtin, an anti-apoptotic protein, become toxic?
Pathologie-biologie 2004;52(6):338-42.
2004: Hélène Rangone; Ghislaine Poizat; Juan C Troncoso; Christopher A Ross; Marcy E MacDonald; Frédéric Saudou; Sandrine Humbert
The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.
The European journal of neuroscience 2004;19(2):273-9.
2003: Nicolas Bizat; Jean-Michel Hermel; Sandrine Humbert; carine Jacquard; Christophe Créminon; Carole Escartin; Frédéric Saudou; Stan Krajewski; Philippe Hantraye; Emmanuel Brouillet
In vivo calpain/caspase cross-talk during 3-nitropropionic acid-induced striatal degeneration: implication of a calpain-mediated cleavage of active caspase-3.
The Journal of biological chemistry 2003;278(44):43245-53.
2003: Sébastien Holbert; Alpaslan Dedeoglu; Sandrine Humbert; Frédéric Saudou; Robert J Ferrante; Christian Néri
Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2712-7.
2002: Sandrine Humbert; Elzbieta A Bryson; Fabrice P Cordelières; Nathan C Connors; Sandeep Robert Datta; Steven Finkbeiner; Michael E Greenberg; Frédéric Saudou
The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.
Developmental cell 2002;2(6):831-7.
2002: Sandrine Humbert; Frédéric Saudou
Toward cell specificity in SCA1.
Neuron 2002;34(5):669-70.
1998: Frédéric Saudou; Steven Finkbeiner; Didier Devys; Michael E Greenberg
Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.
Cell 1998;95(1):55-66.
1998: Noboru Hiroi; Gerard Marek; J R Brown; H Ye; Frédéric Saudou; VA Vaidya; Ronald S Duman; Michael E Greenberg; Eric J Nestler
Essential role of the fosB gene in molecular, cellular, and behavioral actions of chronic electroconvulsive seizures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(17):6952-62.
1998: J R Brown; Elizabeth A Nigh; R J Lee; H Ye; M A Thompson; Frédéric Saudou; R G Pestell; Michael E Greenberg
Fos family members induce cell cycle entry by activating cyclin D1.
Molecular and cellular biology 1998;18(9):5609-19.
1997: Isabelle Gourfinkel-An; G Cancel; Yvon Trottier; Didier Devys; Làszlò Tora; Yves Lutz; G Imbert; Frédéric Saudou; Giovanni Stevanin; Yves Agid; Alexis Brice; Jean-Louis Mandel; Etienne C Hirsch
Differential distribution of the normal and mutated forms of huntingtin in the human brain.
Annals of neurology 1997;42(5):712-9.
1997: G David; Nacer Abbas; Giovanni Stevanin; Alexandra Dürr; Gaël Yvert; G Cancel; C Weber; G Imbert; Frédéric Saudou; E Antoniou; Harry A Drabkin; Robert M Gemmill; Paola Giunti; Ali Benomar; Nicholas W Wood; Merle Ruberg; Yves Agid; Jean-Louis Mandel; Alexis Brice
Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion.
Nature genetics 1997;17(1):65-70.
1997: G Cancel; Alexandra Dürr; O Didierjean; G Imbert; Katrin Bürk; Agnes Lezin; Samir Belal; Ali Benomar; M Abada-Bendib; C Vial; J Guimarães; H Chneiweiss; Giovanni Stevanin; Gaël Yvert; Nacer Abbas; Frédéric Saudou; Anne-Sophie Lebre; Mohamed Yahyaoui; Faycal Hentati; JC Vernant; Thomas Klockgether; Jean-Louis Mandel; Yves Agid; Alexis Brice
Molecular and clinical correlations in spinocerebellar ataxia 2: a study of 32 families.
Human molecular genetics 1997;6(5):709-15.
1996: Giovanni Stevanin; Yvon Trottier; G Cancel; Alexandra Dürr; G David; O Didierjean; Katrin Bürk; G Imbert; Frédéric Saudou; M Abada-Bendib; Isabelle Gourfinkel-An; Ali Benomar; Nacer Abbas; Thomas Klockgether; Djamel Grid; Yves Agid; Jean-Louis Mandel; Alexis Brice
Screening for proteins with polyglutamine expansions in autosomal dominant cerebellar ataxias.
Human molecular genetics 1996;5(12):1887-92.
1996: G Imbert; Frédéric Saudou; Gaël Yvert; Didier Devys; Yvon Trottier; J M Garnier; C Weber; Jean-Louis Mandel; G Cancel; Nacer Abbas; Alexandra Dürr; O Didierjean; Giovanni Stevanin; Yves Agid; Alexis Brice
Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats.
Nature genetics 1996;14(3):285-91.
1996: Frédéric Saudou; Didier Devys; Yvon Trottier; G Imbert; M E Stoeckel; Alexis Brice; Jean-Louis Mandel
Polyglutamine expansions and neurodegenerative diseases.
Cold Spring Harbor symposia on quantitative biology 1996;61():639-47.
1995: Yvon Trottier; Yves Lutz; Giovanni Stevanin; G Imbert; Didier Devys; G Cancel; Frédéric Saudou; C Weber; G David; Làszlò Tora
Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias.
Nature 1995;378(6555):403-6.
1995: Yvon Trottier; Didier Devys; G Imbert; Frédéric Saudou; I An; Yves Lutz; C Weber; Yves Agid; Etienne C Hirsch; Jean-Louis Mandel
Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form.
Nature genetics 1995;10(1):104-10.