Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Robert Sauer

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequence

Concepts & Ideas

Living Beings

Escherichia coli

Disorders

Protein Denaturation

Physiology

Phenomena

Protein Binding

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
51
Baker, Tania
11
Grant, Robert
11
Levchenko, Igor
8
Burton, Randall
7
Flynn, Julia
7
Bolon, Daniel N.
6
Robinson, Clifford
6
Tidor, Bruce
5
Wah, David
5
Walsh, Nathan
5
Moore, Sean
5
Neher, Saskia
5
Martin, Andreas
5
Reidhaar-Olson, John
5
Hecht, Michael

Sign-in to see all Coauthors

Publications

TOP 3
Glynn Steven E; Martin Andreas; Nager Andrew R; Baker Tania A; Sauer Robert T
Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine.
Gur Eyal; Sauer Robert T
Degrons in protein substrates program the speed and operating efficiency of the AAA+ Lon proteolytic machine.
Sohn Jungsan; Grant Robert A; Sauer Robert T
OMP peptides activate the DegS stress-sensor protease by a relief of inhibition mechanism.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Robert Sauer (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Glynn Steven E; Martin Andreas; Nager Andrew R; Baker Tania A; Sauer Robert T
Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine.
Cell 2009;139(4):744-56.
2009: Gur Eyal; Sauer Robert T
Degrons in protein substrates program the speed and operating efficiency of the AAA+ Lon proteolytic machine.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(44):18503-8.
2009: Sohn Jungsan; Grant Robert A; Sauer Robert T
OMP peptides activate the DegS stress-sensor protease by a relief of inhibition mechanism.
Structure (London, England : 1993) 2009;17(10):1411-21.
2009: Barkow Sarah R; Levchenko Igor; Baker Tania A; Sauer Robert T
Polypeptide translocation by the AAA+ ClpXP protease machine.
Chemistry & biology 2009;16(6):605-12.
2009: Román-Hernández Giselle; Grant Robert A; Sauer Robert T; Baker Tania A
Molecular basis of substrate selection by the N-end rule adaptor protein ClpS.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(22):8888-93.
2009: Cezairliyan Brent O; Sauer Robert T
Control of Pseudomonas aeruginosa AlgW protease cleavage of MucA by peptide signals and MucB.
Molecular microbiology 2009;72(2):368-79.
2009: Sohn Jungsan; Sauer Robert T
OMP peptides modulate the activity of DegS protease by differential binding to active and inactive conformations.
Molecular cell 2009;33(1):64-74.
2008: Moore Sean D; Sauer Robert T
Revisiting the mechanism of macrolide-antibiotic resistance mediated by ribosomal protein L22.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18261-6.
2008: Wang Kevin H; Roman-Hernandez Giselle; Grant Robert A; Sauer Robert T; Baker Tania A
The molecular basis of N-end rule recognition.
Molecular cell 2008;32(3):406-14.
2008: Martin Andreas; Baker Tania A; Sauer Robert T
Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding.
Nature structural & molecular biology 2008;15(11):1147-51.
2008: Gur Eyal; Sauer Robert T
Evolution of the ssrA degradation tag in Mycoplasma: specificity switch to a different protease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(42):16113-8.
2008: Wang Kevin H; Oakes Elizabeth S C; Sauer Robert T; Baker Tania A
Tuning the strength of a bacterial N-end rule degradation signal.
The Journal of biological chemistry 2008;283(36):24600-7.
2008: Gur Eyal; Sauer Robert T
Recognition of misfolded proteins by Lon, a AAA(+) protease.
Genes & development 2008;22(16):2267-77.
2008: Moore Sean D; Baker Tania A; Sauer Robert T
Forced extraction of targeted components from complex macromolecular assemblies.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11685-90.
2008: Yakamavich Joseph A; Baker Tania A; Sauer Robert T
Asymmetric nucleotide transactions of the HslUV protease.
Journal of molecular biology 2008;380(5):946-57.
2008: Abdelhakim Aliaa H; Oakes Elizabeth C; Sauer Robert T; Baker Tania A
Unique contacts direct high-priority recognition of the tetrameric Mu transposase-DNA complex by the AAA+ unfoldase ClpX.
Molecular cell 2008;30(1):39-50.
2008: Martin Andreas; Baker Tania A; Sauer Robert T
Diverse pore loops of the AAA+ ClpX machine mediate unassisted and adaptor-dependent recognition of ssrA-tagged substrates.
Molecular cell 2008;29(4):441-50.
2007: Sohn Jungsan; Grant Robert A; Sauer Robert T
Allosteric activation of DegS, a stress sensor PDZ protease.
Cell 2007;131(3):572-83.
2007: Chien Peter; Grant Robert A; Sauer Robert T; Baker Tania A
Structure and substrate specificity of an SspB ortholog: design implications for AAA+ adaptors.
Structure (London, England : 1993) 2007;15(10):1296-305.
2007: Martin Andreas; Baker Tania A; Sauer Robert T
Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease.
Molecular cell 2007;27(1):41-52.
2007: Chien Peter; Perchuk Barrett S; Laub Michael T; Sauer Robert T; Baker Tania A
Direct and adaptor-mediated substrate recognition by an essential AAA+ protease.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6590-5.
2007: McGinness Kathleen E; Bolon Daniel N; Kaganovich Mark; Baker Tania A; Sauer Robert T
Altered tethering of the SspB adaptor to the ClpXP protease causes changes in substrate delivery.
The Journal of biological chemistry 2007;282(15):11465-73.
2007: Cezairliyan Brent O; Sauer Robert T
Inhibition of regulated proteolysis by RseB.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3771-6.
2007: Wang Kevin H; Sauer Robert T; Baker Tania A
ClpS modulates but is not essential for bacterial N-end rule degradation.
Genes & development 2007;21(4):403-8.
2007: Farrell Christopher M; Baker Tania A; Sauer Robert T
Altered specificity of a AAA+ protease.
Molecular cell 2007;25(1):161-6.
2007: Moore Sean D; Sauer Robert T
The tmRNA system for translational surveillance and ribosome rescue.
Annual review of biochemistry 2007;76():101-24.
2006: Baker Tania A; Sauer Robert T
ATP-dependent proteases of bacteria: recognition logic and operating principles.
Trends in biochemical sciences 2006;31(12):647-53.
2006: McGinness Kathleen E; Baker Tania A; Sauer Robert T
Engineering controllable protein degradation.
Molecular cell 2006;22(5):701-7.
2006: Neher Saskia B; Villén Judit; Oakes Elizabeth C; Bakalarski Corey E; Sauer Robert T; Gygi Steven P; Baker Tania A
Proteomic profiling of ClpXP substrates after DNA damage reveals extensive instability within SOS regulon.
Molecular cell 2006;22(2):193-204.
2005: Anderson Thomas A; Cordes Matthew H J; Sauer Robert T
Sequence determinants of a conformational switch in a protein structure.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18344-9.
2005: Martin Andreas; Baker Tania A; Sauer Robert T
Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines.
Nature 2005;437(7062):1115-20.
2005: Moore Sean D; Sauer Robert T
Ribosome rescue: tmRNA tagging activity and capacity in Escherichia coli.
Molecular microbiology 2005;58(2):456-66.
2005: Farrell Christopher M; Grossman Alan D; Sauer Robert T
Cytoplasmic degradation of ssrA-tagged proteins.
Molecular microbiology 2005;57(6):1750-61.
2005: Bolon Daniel N; Grant Robert A; Baker Tania A; Sauer Robert T
Specificity versus stability in computational protein design.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(36):12724-9.
2005: Hersch Greg L; Burton Randall E; Bolon Daniel N; Baker Tania A; Sauer Robert T
Asymmetric interactions of ATP with the AAA+ ClpX6 unfoldase: allosteric control of a protein machine.
Cell 2005;121(7):1017-27.
2005: Levchenko Igor; Grant Robert A; Flynn Julia M; Sauer Robert T; Baker Tania A
Versatile modes of peptide recognition by the AAA+ adaptor protein SspB.
Nature structural & molecular biology 2005;12(6):520-5.
2005: Burton Randall E; Baker Tania A; Sauer Robert T
Nucleotide-dependent substrate recognition by the AAA+ HslUV protease.
Nature structural & molecular biology 2005;12(3):245-51.
2005: Tabtiang Ramon K; Cezairliyan Brent O; Grant Robert A; Cochrane Jesse C; Sauer Robert T
Consolidating critical binding determinants by noncyclic rearrangement of protein secondary structure.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2305-9.
2005: Kenniston Jon A; Baker Tania A; Sauer Robert T
Partitioning between unfolding and release of native domains during ClpXP degradation determines substrate selectivity and partial processing.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1390-5.
2004: Bolon Daniel N; Grant Robert A; Baker Tania A; Sauer Robert T
Nucleotide-dependent substrate handoff from the SspB adaptor to the AAA+ ClpXP protease.
Molecular cell 2004;16(3):343-50.
2004: Sauer Robert T; Bolon Daniel N; Burton Briana M; Burton Randall E; Flynn Julia M; Grant Robert A; Hersch Greg L; Joshi Shilpa A; Kenniston Jon A; Levchenko Igor; Neher Saskia B; Oakes Elizabeth S C; Siddiqui Samia M; Wah David A; Baker Tania A
Sculpting the proteome with AAA(+) proteases and disassembly machines.
Cell 2004;119(1):9-18.
2004: Flynn Julia M; Levchenko Igor; Sauer Robert T; Baker Tania A
Modulating substrate choice: the SspB adaptor delivers a regulator of the extracytoplasmic-stress response to the AAA+ protease ClpXP for degradation.
Genes & development 2004;18(18):2292-301.
2004: McGinness Kathleen E; Sauer Robert T
Ribosomal protein S1 binds mRNA and tmRNA similarly but plays distinct roles in translation of these molecules.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(37):13454-9.
2004: Kenniston Jon A; Sauer Robert T
Signaling degradation.
Nature structural & molecular biology 2004;11(9):800-2.
2004: Hersch Greg L; Baker Tania A; Sauer Robert T
SspB delivery of substrates for ClpXP proteolysis probed by the design of improved degradation tags.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(33):12136-41.
2004: Spector Shari; Sauer Robert T; Tidor Bruce
Computational and experimental probes of symmetry mismatches in the Arc repressor-DNA complex.
Journal of molecular biology 2004;340(2):253-61.
2004: Joshi Shilpa A; Hersch Greg L; Baker Tania A; Sauer Robert T
Communication between ClpX and ClpP during substrate processing and degradation.
Nature structural & molecular biology 2004;11(5):404-11.
2004: Kenniston Jon A; Burton Randall E; Siddiqui Samia M; Baker Tania A; Sauer Robert T
Effects of local protein stability and the geometric position of the substrate degradation tag on the efficiency of ClpXP denaturation and degradation.
Journal of structural biology 2004;146(1-2):130-40.
2004: Siddiqui Samia M; Sauer Robert T; Baker Tania A
Role of the processing pore of the ClpX AAA+ ATPase in the recognition and engagement of specific protein substrates.
Genes & development 2004;18(4):369-74.
2004: Bolon Daniel N; Wah David A; Hersch Greg L; Baker Tania A; Sauer Robert T
Bivalent tethering of SspB to ClpXP is required for efficient substrate delivery: a protein-design study.
Molecular cell 2004;13(3):443-9.
2003: Spector Shari; Flynn Julia M; Tidor Bruce; Baker Tania A; Sauer Robert T
Expression of N-formylated proteins in Escherichia coli.
Protein expression and purification 2003;32(2):317-22.
2003: Neher Saskia B; Sauer Robert T; Baker Tania A
Distinct peptide signals in the UmuD and UmuD' subunits of UmuD/D' mediate tethering and substrate processing by the ClpXP protease.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13219-24.
2003: Hayes Christopher S; Sauer Robert T
Cleavage of the A site mRNA codon during ribosome pausing provides a mechanism for translational quality control.
Molecular cell 2003;12(4):903-11.
2003: Schreiter Eric R; Sintchak Michael D; Guo Yayi; Chivers Peter T; Sauer Robert T; Drennan Catherine L
Crystal structure of the nickel-responsive transcription factor NikR.
Nature structural biology 2003;10(10):794-9.
2003: Levchenko Igor; Grant Robert A; Wah David A; Sauer Robert T; Baker Tania A
Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag.
Molecular cell 2003;12(2):365-72.
2003: Wah David A; Levchenko Igor; Rieckhof Gabrielle E; Bolon Daniel N; Baker Tania A; Sauer Robert T
Flexible linkers leash the substrate binding domain of SspB to a peptide module that stabilizes delivery complexes with the AAA+ ClpXP protease.
Molecular cell 2003;12(2):355-63.
2003: Kenniston Jon A; Baker Tania A; Fernandez Julio M; Sauer Robert T
Linkage between ATP consumption and mechanical unfolding during the protein processing reactions of an AAA+ degradation machine.
Cell 2003;114(4):511-20.
2003: Neher Saskia B; Flynn Julia M; Sauer Robert T; Baker Tania A
Latent ClpX-recognition signals ensure LexA destruction after DNA damage.
Genes & development 2003;17(9):1084-9.
2003: Burton Randall E; Baker Tania A; Sauer Robert T
Energy-dependent degradation: Linkage between ClpX-catalyzed nucleotide hydrolysis and protein-substrate processing.
Protein science : a publication of the Protein Society 2003;12(5):893-902.
2003: Walsh Nathan P; Alba Benjamin M; Bose Baundauna; Gross Carol A; Sauer Robert T
OMP peptide signals initiate the envelope-stress response by activating DegS protease via relief of inhibition mediated by its PDZ domain.
Cell 2003;113(1):61-71.
2003: Moore Sean D; McGinness Kathleen E; Sauer Robert T
Structural biology. A glimpse into tmRNA-mediated ribosome rescue.
Science (New York, N.Y.) 2003;300(5616):72-3.
2003: Joshi Shilpa A; Baker Tania A; Sauer Robert T
C-terminal domain mutations in ClpX uncouple substrate binding from an engagement step required for unfolding.
Molecular microbiology 2003;48(1):67-76.
2003: Flynn Julia M; Neher Saskia B; Kim Yong In; Sauer Robert T; Baker Tania A
Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals.
Molecular cell 2003;11(3):671-83.
2003: Cordes Matthew H J; Walsh Nathan P; McKnight C James; Sauer Robert T
Solution structure of switch Arc, a mutant with 3(10) helices replacing a wild-type beta-ribbon.
Journal of molecular biology 2003;326(3):899-909.
2003: Carrington Paul E; Chivers Peter T; Al-Mjeni Faizah; Sauer Robert T; Maroney Michael J
Nickel coordination is regulated by the DNA-bound state of NikR.
Nature structural biology 2003;10(2):126-30.
2003: Hayes Christopher S; Sauer Robert T
Toxin-antitoxin pairs in bacteria: killers or stress regulators?
Cell 2003;112(1):2-4.
2003: Anderson Thomas A; Sauer Robert T
Role of an N(cap) residue in determining the stability and operator-binding affinity of Arc repressor.
Biophysical chemistry 2003;100(1-3):341-50.
2002: Srivastava Alok K; Sauer Robert T
Mutational studies of protein stability and folding of the hyperstable MYL Arc repressor variant.
Biophysical chemistry 2002;101-102():35-42.
2002: Wah David A; Levchenko Igor; Baker Tania A; Sauer Robert T
Characterization of a specificity factor for an AAA+ ATPase: assembly of SspB dimers with ssrA-tagged proteins and the ClpX hexamer.
Chemistry & biology 2002;9(11):1237-45.
2002: Chivers Peter T; Sauer Robert T
NikR repressor: high-affinity nickel binding to the C-terminal domain regulates binding to operator DNA.
Chemistry & biology 2002;9(10):1141-8.
2002: Hayes Christopher S; Bose Baundauna; Sauer Robert T
Proline residues at the C terminus of nascent chains induce SsrA tagging during translation termination.
The Journal of biological chemistry 2002;277(37):33825-32.
2002: Hayes Christopher S; Bose Baundauna; Sauer Robert T
Stop codons preceded by rare arginine codons are efficient determinants of SsrA tagging in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3440-5.
2001: Barends S; Karzai A W; Sauer R T; Wower J; Kraal B
Simultaneous and functional binding of SmpB and EF-Tu-TP to the alanyl acceptor arm of tmRNA.
Journal of molecular biology 2001;314(1):9-21.
2001: Flynn J M; Levchenko I; Seidel M; Wickner S H; Sauer R T; Baker T A
Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10584-9.
2001: Roche E D; Sauer R T
Identification of endogenous SsrA-tagged proteins reveals tagging at positions corresponding to stop codons.
The Journal of biological chemistry 2001;276(30):28509-15.
2001: Burton R E; Siddiqui S M; Kim Y I; Baker T A; Sauer R T
Effects of protein stability and structure on substrate processing by the ClpXP unfolding and degradation machine.
The EMBO journal 2001;20(12):3092-100.
2001: Lo J H; Baker T A; Sauer R T
Characterization of the N-terminal repeat domain of Escherichia coli ClpA-A class I Clp/HSP100 ATPase.
Protein science : a publication of the Protein Society 2001;10(3):551-9.
2001: Nohaile M J; Hendsch Z S; Tidor B; Sauer R T
Altering dimerization specificity by changes in surface electrostatics.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3109-14.
2001: Karzai A W; Sauer R T
Protein factors associated with the SsrA.SmpB tagging and ribosome rescue complex.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3040-4.
2001: Kim Y I; Levchenko I; Fraczkowska K; Woodruff R V; Sauer R T; Baker T A
Molecular determinants of complex formation between Clp/Hsp100 ATPases and the ClpP peptidase.
Nature structural biology 2001;8(3):230-3.
2001: Hendsch Z S; Nohaile M J; Sauer R T; Tidor B
Preferential heterodimer formation via undercompensated electrostatic interactions.
Journal of the American Chemical Society 2001;123(6):1264-5.
2001: Berggrun A; Sauer R T
Contributions of distinct quaternary contacts to cooperative operator binding by Mnt repressor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2301-5.
2000: Cordes M H; Burton R E; Walsh N P; McKnight C J; Sauer R T
An evolutionary bridge to a new protein fold.
Nature structural biology 2000;7(12):1129-32.
2000: Robinson C R; Sauer R T
Striking stabilization of Arc repressor by an engineered disulfide bond.
Biochemistry 2000;39(40):12494-502.
2000: Levchenko I; Seidel M; Sauer R T; Baker T A
A specificity-enhancing factor for the ClpXP degradation machine.
Science (New York, N.Y.) 2000;289(5488):2354-6.
2000: Berggrun A; Sauer R T
Interactions of Arg2 in the Mnt N-terminal arm with the central and flanking regions of the Mnt operator.
Journal of molecular biology 2000;301(4):959-73.
2000: Srivastava A K; Sauer R T
Evidence for partial secondary structure formation in the transition state for arc repressor refolding and dimerization.
Biochemistry 2000;39(28):8308-14.
2000: Karzai A W; Roche E D; Sauer R T
The SsrA-SmpB system for protein tagging, directed degradation and ribosome rescue.
Nature structural biology 2000;7(6):449-55.
2000: Chivers P T; Sauer R T
Regulation of high affinity nickel uptake in bacteria. Ni2+-Dependent interaction of NikR with wild-type and mutant operator sites.
The Journal of biological chemistry 2000;275(26):19735-41.
2000: Kim Y I; Burton R E; Burton B M; Sauer R T; Baker T A
Dynamics of substrate denaturation and translocation by the ClpXP degradation machine.
Molecular cell 2000;5(4):639-48.
1999: Chivers P T; Sauer R T
NikR is a ribbon-helix-helix DNA-binding protein.
Protein science : a publication of the Protein Society 1999;8(11):2494-500.
1999: Roche E D; Sauer R T
SsrA-mediated peptide tagging caused by rare codons and tRNA scarcity.
The EMBO journal 1999;18(16):4579-89.
1999: Karzai A W; Susskind M M; Sauer R T
SmpB, a unique RNA-binding protein essential for the peptide-tagging activity of SsrA (tmRNA).
The EMBO journal 1999;18(13):3793-9.
1999: Rentzeperis D; Jonsson T; Sauer R T
Acceleration of the refolding of Arc repressor by nucleic acids and other polyanions.
Nature structural biology 1999;6(6):569-73.
1999: Smith C K; Baker T A; Sauer R T
Lon and Clp family proteases and chaperones share homologous substrate-recognition domains.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6678-82.
1999: Gazit E; Sauer R T
The Doc toxin and Phd antidote proteins of the bacteriophage P1 plasmid addiction system form a heterotrimeric complex.
The Journal of biological chemistry 1999;274(24):16813-8.
1999: Cordes M H; Walsh N P; McKnight C J; Sauer R T
Evolution of a protein fold in vitro.
Science (New York, N.Y.) 1999;284(5412):325-8.
1999: Brown B M; Sauer R T
Tolerance of Arc repressor to multiple-alanine substitutions.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):1983-8.
1999: Cordes M H; Sauer R T
Tolerance of a protein to multiple polar-to-hydrophobic surface substitutions.
Protein science : a publication of the Protein Society 1999;8(2):318-25.
1999: Schildbach J F; Karzai A W; Raumann B E; Sauer R T
Origins of DNA-binding specificity: role of protein contacts with the DNA backbone.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(3):811-7.
1999: Gazit E; Sauer R T
Stability and DNA binding of the phd protein of the phage P1 plasmid addiction system.
The Journal of biological chemistry 1999;274(5):2652-7.
1998: Robinson C R; Sauer R T
Optimizing the stability of single-chain proteins by linker length and composition mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):5929-34.
1998: Schildbach J F; Robinson C R; Sauer R T
Biophysical characterization of the TraY protein of Escherichia coli F factor.
The Journal of biological chemistry 1998;273(3):1329-33.
1997: Levchenko I; Smith C K; Walsh N P; Sauer R T; Baker T A
PDZ-like domains mediate binding specificity in the Clp/Hsp100 family of chaperones and protease regulatory subunits.
Cell 1997;91(7):939-47.
1997: Robinson C R; Rentzeperis D; Silva J L; Sauer R T
Formation of a denatured dimer limits the thermal stability of Arc repressor.
Journal of molecular biology 1997;273(3):692-700.
1997: Tucker-Kellogg L; Rould M A; Chambers K A; Ades S E; Sauer R T; Pabo C O
Engrailed (Gln50-->Lys) homeodomain-DNA complex at 1.9 A resolution: structural basis for enhanced affinity and altered specificity.
Structure (London, England : 1993) 1997;5(8):1047-54.
1996: Smith T L; Sauer R T
Role of operator subsites in Arc repression.
Journal of molecular biology 1996;264(2):233-42.
1996: Robinson C R; Sauer R T
Equilibrium stability and sub-millisecond refolding of a designed single-chain Arc repressor.
Biochemistry 1996;35(44):13878-84.
1996: Waldburger C D; Sauer R T
Signal detection by the PhoQ sensor-transmitter. Characterization of the sensor domain and a response-impaired mutant that identifies ligand-binding determinants.
The Journal of biological chemistry 1996;271(43):26630-6.
1996: Kolmar H; Waller P R; Sauer R T
The DegP and DegQ periplasmic endoproteases of Escherichia coli: specificity for cleavage sites and substrate conformation.
Journal of bacteriology 1996;178(20):5925-9.
1996: Smith T L; Sauer R T
Dual regulation of open-complex formation and promoter clearance by Arc explains a novel repressor to activator switch.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):8868-72.
1996: Hendsch Z S; Jonsson T; Sauer R T; Tidor B
Protein stabilization by removal of unsatisfied polar groups: computational approaches and experimental tests.
Biochemistry 1996;35(24):7621-5.
1996: Jonsson T; Waldburger C D; Sauer R T
Nonlinear free energy relationships in Arc repressor unfolding imply the existence of unstable, native-like folding intermediates.
Biochemistry 1996;35(15):4795-802.
1996: Waldburger C D; Jonsson T; Sauer R T
Barriers to protein folding: formation of buried polar interactions is a slow step in acquisition of structure.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):2629-34.
1996: Cordes M H; Davidson A R; Sauer R T
Sequence space, folding and protein design.
Current opinion in structural biology 1996;6(1):3-10.
1996: Keiler K C; Waller P R; Sauer R T
Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA.
Science (New York, N.Y.) 1996;271(5251):990-3.
1996: Keiler K C; Sauer R T
Sequence determinants of C-terminal substrate recognition by the Tsp protease.
The Journal of biological chemistry 1996;271(5):2589-93.
1996: Waller P R; Sauer R T
Characterization of degQ and degS, Escherichia coli genes encoding homologs of the DegP protease.
Journal of bacteriology 1996;178(4):1146-53.
1996: Sauer R T; Milla M E; Waldburger C D; Brown B M; Schildbach J F
Sequence determinants of folding and stability for the P22 Arc repressor dimer.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(1):42-8.
1996: Robinson C R; Sauer R T
Covalent attachment of Arc repressor subunits by a peptide linker enhances affinity for operator DNA.
Biochemistry 1996;35(1):109-16.
1995: Raumann B E; Knight K L; Sauer R T
Dramatic changes in DNA-binding specificity caused by single residue substitutions in an Arc/Mnt hybrid repressor.
Nature structural biology 1995;2(12):1115-22.
1995: Keiler K C; Sauer R T
Identification of active site residues of the Tsp protease.
The Journal of biological chemistry 1995;270(48):28864-8.
1995: Ades S E; Sauer R T
Specificity of minor-groove and major-groove interactions in a homeodomain-DNA complex.
Biochemistry 1995;34(44):14601-8.
1995: Milla M E; Brown B M; Waldburger C D; Sauer R T
P22 Arc repressor: transition state properties inferred from mutational effects on the rates of protein unfolding and refolding.
Biochemistry 1995;34(42):13914-9.
1995: Davidson A R; Lumb K J; Sauer R T
Cooperatively folded proteins in random sequence libraries.
Nature structural biology 1995;2(10):856-64.
1995: Waldburger C D; Sauer R T
Domains of Mnt repressor: roles in tetramer formation, protein stability, and operator DNA binding.
Biochemistry 1995;34(40):13109-16.
1995: Keiler K C; Silber K R; Downard K M; Papayannopoulos I A; Biemann K; Sauer R T
C-terminal specific protein degradation: activity and substrate specificity of the Tsp protease.
Protein science : a publication of the Protein Society 1995;4(8):1507-15.
1995: Smith T L; Sauer R T
P22 Arc repressor: role of cooperativity in repression and binding to operators with altered half-site spacing.
Journal of molecular biology 1995;249(4):729-42.
1995: Milla M E; Sauer R T
Critical side-chain interactions at a subunit interface in the Arc repressor dimer.
Biochemistry 1995;34(10):3344-51.
1995: Waldburger C D; Schildbach J F; Sauer R T
Are buried salt bridges important for protein stability and conformational specificity?
Nature structural biology 1995;2(2):122-8.
1995: Schildbach J F; Milla M E; Jeffrey P D; Raumann B E; Sauer R T
Crystal structure, folding, and operator binding of the hyperstable Arc repressor mutant PL8.
Biochemistry 1995;34(4):1405-12.
1994: Marqusee S; Sauer R T
Contributions of a hydrogen bond/salt bridge network to the stability of secondary and tertiary structure in lambda repressor.
Protein science : a publication of the Protein Society 1994;3(12):2217-25.
1994: Ades S E; Sauer R T
Differential DNA-binding specificity of the engrailed homeodomain: the role of residue 50.
Biochemistry 1994;33(31):9187-94.
1994: Milla M E; Brown B M; Sauer R T
Protein stability effects of a complete set of alanine substitutions in Arc repressor.
Nature structural biology 1994;1(8):518-23.
1994: Waugh D S; Sauer R T
A novel class of FokI restriction endonuclease mutants that cleave hemi-methylated substrates.
The Journal of biological chemistry 1994;269(16):12298-303.
1994: Davidson A R; Sauer R T
Folded proteins occur frequently in libraries of random amino acid sequences.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2146-50.
1994: Brown B M; Milla M E; Smith T L; Sauer R T
Scanning mutagenesis of the Arc repressor as a functional probe of operator recognition.
Nature structural biology 1994;1(3):164-8.
1994: Milla M E; Sauer R T
P22 Arc repressor: folding kinetics of a single-domain, dimeric protein.
Biochemistry 1994;33(5):1125-33.
1994: Raumann B E; Rould M A; Pabo C O; Sauer R T
DNA recognition by beta-sheets in the Arc repressor-operator crystal structure.
Nature 1994;367(6465):754-7.
1994: Silber K R; Sauer R T
Deletion of the prc (tsp) gene provides evidence for additional tail-specific proteolytic activity in Escherichia coli K-12.
Molecular & general genetics : MGG 1994;242(2):237-40.
1993: Milla M E; Brown B M; Sauer R T
P22 Arc repressor: enhanced expression of unstable mutants by addition of polar C-terminal sequences.
Protein science : a publication of the Protein Society 1993;2(12):2198-205.
1993: Waugh D S; Sauer R T
Single amino acid substitutions uncouple the DNA binding and strand scission activities of Fok I endonuclease.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9596-600.
1993: Hu J C; Newell N E; Tidor B; Sauer R T
Probing the roles of residues at the e and g positions of the GCN4 leucine zipper by combinatorial mutagenesis.
Protein science : a publication of the Protein Society 1993;2(7):1072-84.
1993: Gregoret L M; Sauer R T
Additivity of mutant effects assessed by binomial mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4246-50.
1993: Brown B M; Sauer R T
Assembly of the Arc repressor-operator complex: cooperative interactions between DNA-bound dimers.
Biochemistry 1993;32(5):1354-63.
1992: Lim W A; Farruggio D C; Sauer R T
Structural and energetic consequences of disruptive mutations in a protein core.
Biochemistry 1992;31(17):4324-33.
1992: Knight K L; Sauer R T
Biochemical and genetic analysis of operator contacts made by residues within the beta-sheet DNA binding motif of Mnt repressor.
The EMBO journal 1992;11(1):215-23.
1992: Silber K R; Keiler K C; Sauer R T
Tsp: a tail-specific protease that selectively degrades proteins with nonpolar C termini.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):295-9.
1992: Pabo C O; Sauer R T
Transcription factors: structural families and principles of DNA recognition.
Annual review of biochemistry 1992;61():1053-95.
1991: Lim W A; Sauer R T
The role of internal packing interactions in determining the structure and stability of a protein.
Journal of molecular biology 1991;219(2):359-76.
1991: Mossing M C; Bowie J U; Sauer R T
A streptomycin selection for DNA-binding activity.
Methods in enzymology 1991;208():604-19.
1991: Reidhaar-Olson J F; Bowie J U; Breyer R M; Hu J C; Knight K L; Lim W A; Mossing M C; Parsell D A; Shoemaker K R; Sauer R T
Random mutagenesis of protein sequences using oligonucleotide cassettes.
Methods in enzymology 1991;208():564-86.
1990: Brown B M; Bowie J U; Sauer R T
Arc repressor is tetrameric when bound to operator DNA.
Biochemistry 1990;29(51):11189-95.
1990: Mossing M C; Sauer R T
Stable, monomeric variants of lambda Cro obtained by insertion of a designed beta-hairpin sequence.
Science (New York, N.Y.) 1990;250(4988):1712-5.
1990: Hu J C; O'Shea E K; Kim P S; Sauer R T
Sequence requirements for coiled-coils: analysis with lambda repressor-GCN4 leucine zipper fusions.
Science (New York, N.Y.) 1990;250(4986):1400-3.
1990: Reidhaar-Olson J F; Parsell D A; Sauer R T
An essential proline in lambda repressor is required for resistance to intracellular proteolysis.
Biochemistry 1990;29(33):7563-71.
1990: Bowie J U; Reidhaar-Olson J F; Lim W A; Sauer R T
Deciphering the message in protein sequences: tolerance to amino acid substitutions.
Science (New York, N.Y.) 1990;247(4948):1306-10.
1990: Pakula A A; Sauer R T
Reverse hydrophobic effects relieved by amino-acid substitutions at a protein surface.
Nature 1990;344(6264):363-4.
1990: Parsell D A; Silber K R; Sauer R T
Carboxy-terminal determinants of intracellular protein degradation.
Genes & development 1990;4(2):277-86.
1990: Bowie J U; Sauer R T
TraY proteins of F and related episomes are members of the Arc and Mnt repressor family.
Journal of molecular biology 1990;211(1):5-6.
1990: Reidhaar-Olson J F; Sauer R T
Functionally acceptable substitutions in two alpha-helical regions of lambda repressor.
Proteins 1990;7(4):306-16.
1990: Bowie J U; Clarke N D; Pabo C O; Sauer R T
Identification of protein folds: matching hydrophobicity patterns of sequence sets with solvent accessibility patterns of known structures.
Proteins 1990;7(3):257-64.
1989: Zagorski M G; Bowie J U; Vershon A K; Sauer R T; Patel D J
NMR studies of Arc repressor mutants: proton assignments, secondary structure, and long-range contacts for the thermostable proline-8----leucine variant of Arc.
Biochemistry 1989;28(25):9813-25.
1989: Bowie J U; Sauer R T
Equilibrium dissociation and unfolding of the Arc repressor dimer.
Biochemistry 1989;28(18):7139-43.
1989: Parsell D A; Sauer R T
Induction of a heat shock-like response by unfolded protein in Escherichia coli: dependence on protein level not protein degradation.
Genes & development 1989;3(8):1226-32.
1989: Knight K L; Sauer R T
Identification of functionally important residues in the DNA binding region of the mnt repressor.
The Journal of biological chemistry 1989;264(23):13706-10.
1989: Breyer R M; Sauer R T
Mutational analysis of the fine specificity of binding of monoclonal antibody 51F to lambda repressor.
The Journal of biological chemistry 1989;264(22):13355-60.
1989: Breyer R M; Sauer R T
Production and characterization of monoclonal antibodies to the N-terminal domain of lambda repressor.
The Journal of biological chemistry 1989;264(22):13348-54.
1989: Bowie J U; Sauer R T
Identification of C-terminal extensions that protect proteins from intracellular proteolysis.
The Journal of biological chemistry 1989;264(13):7596-602.
1989: Parsell D A; Sauer R T
The structural stability of a protein is an important determinant of its proteolytic susceptibility in Escherichia coli.
The Journal of biological chemistry 1989;264(13):7590-5.
1989: Lim W A; Sauer R T
Alternative packing arrangements in the hydrophobic core of lambda repressor.
Nature 1989;339(6219):31-6.
1989: Bowie J U; Sauer R T
Identifying determinants of folding and activity for a protein of unknown structure.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2152-6.
1989: Knight K L; Bowie J U; Vershon A K; Kelley R D; Sauer R T
The Arc and Mnt repressors. A new class of sequence-specific DNA-binding protein.
The Journal of biological chemistry 1989;264(7):3639-42.
1989: Gimble F S; Sauer R T
Lambda repressor mutants that are better substrates for RecA-mediated cleavage.
Journal of molecular biology 1989;206(1):29-39.
1989: Vershon A K; Kelley R D; Sauer R T
Sequence-specific binding of arc repressor to DNA. Effects of operator mutations and modifications.
The Journal of biological chemistry 1989;264(6):3267-73.
1989: Knight K L; Sauer R T
DNA binding specificity of the Arc and Mnt repressors is determined by a short region of N-terminal residues.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):797-801.
1989: Pakula A A; Sauer R T
Amino acid substitutions that increase the thermal stability of the lambda Cro protein.
Proteins 1989;5(3):202-10.
1988: Reidhaar-Olson J F; Sauer R T
Combinatorial cassette mutagenesis as a probe of the informational content of protein sequences.
Science (New York, N.Y.) 1988;241(4861):53-7.
1988: Knight K L; Sauer R T
The Mnt repressor of bacteriophage P22: role of C-terminal residues in operator binding and tetramer formation.
Biochemistry 1988;27(6):2088-94.
1987: Weiss M A; Karplus M; Sauer R T
Quaternary structure and function in phage lambda repressor: 1H-NMR studies of genetically altered proteins.
Journal of biomolecular structure & dynamics 1987;5(3):539-56.
1987: Vershon A K; Liao S M; McClure W R; Sauer R T
Interaction of the bacteriophage P22 Arc repressor with operator DNA.
Journal of molecular biology 1987;195(2):323-31.
1987: Vershon A K; Liao S M; McClure W R; Sauer R T
Bacteriophage P22 Mnt repressor. DNA binding and effects on transcription in vitro.
Journal of molecular biology 1987;195(2):311-22.
1986: Vershon A K; Bowie J U; Karplus T M; Sauer R T
Isolation and analysis of arc repressor mutants: evidence for an unusual mechanism of DNA binding.
Proteins 1986;1(4):302-11.
1986: Hecht M H; Sturtevant J M; Sauer R T
Stabilization of lambda repressor against thermal denaturation by site-directed Gly----Ala changes in alpha-helix 3.
Proteins 1986;1(1):43-6.
1986: Poteete A R; Hehir K; Sauer R T
Bacteriophage P22 Cro protein: sequence, purification, and properties.
Biochemistry 1986;25(1):251-6.
1985: Hecht M H; Hehir K M; Nelson H C; Sturtevant J M; Sauer R T
Increasing and decreasing protein stability: effects of revertant substitutions on the thermal denaturation of phage lambda repressor.
Journal of cellular biochemistry 1985;29(3):217-24.
1983: Sauer R T; Nelson H C; Hehir K; Hecht M H; Gimble F S; DeAnda J; Poteete A R
The lambda and P22 phage repressors.
Journal of biomolecular structure & dynamics 1983;1(4):1011-22.
1983: Hecht M H; Nelson H C; Sauer R T
Mutations in lambda repressor's amino-terminal domain: implications for protein stability and DNA binding.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(9):2676-80.
1983: Nelson H C; Hecht M H; Sauer R T
Mutations defining the operator-binding sites of bacteriophage lambda repressor.
Cold Spring Harbor symposia on quantitative biology 1983;47 Pt 1():441-9.
1981: Sauer R T; Pan J; Hopper P; Hehir K; Brown J; Poteete A R
Primary structure of the phage P22 repressor and its gene c2.
Biochemistry 1981;20(12):3591-8.

Sign-in to see more