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Robert Sauer

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Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

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Escherichia coli

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Protein Denaturation

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TOP 3
Santiago Lima; Rachna Chaba; Carol A Gross; Monica S Guo; Robert T Sauer
Dual molecular signals mediate the bacterial response to outer-membrane stress.
Benjamin M Stinson; Karl R Schmitz; Tania A Baker; Steven E Glynn; Andrew R Nager; Robert T Sauer
Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine.
Matthew L Wohlever; Tania A Baker; Andrew R Nager; Robert T Sauer
Engineering fluorescent protein substrates for the AAA+ Lon protease.

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All Publications

2013: Santiago Lima; Rachna Chaba; Carol A Gross; Monica S Guo; Robert T Sauer
Dual molecular signals mediate the bacterial response to outer-membrane stress.
Science (New York, N.Y.) 2013;340(6134):837-41.
2013: Benjamin M Stinson; Karl R Schmitz; Tania A Baker; Steven E Glynn; Andrew R Nager; Robert T Sauer
Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine.
Cell 2013;153(3):628-39.
2013: Matthew L Wohlever; Tania A Baker; Andrew R Nager; Robert T Sauer
Engineering fluorescent protein substrates for the AAA+ Lon protease.
Protein engineering, design & selection : PEDS 2013;26(4):299-305.
2013: Dominik Barthelme; Robert T Sauer
Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20S peptidase.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(9):3327-32.
2013: Randall V Mauldin; Robert T Sauer
Allosteric regulation of DegS protease subunits through a shared energy landscape.
Nature chemical biology 2013;9(2):90-6.
2012: Dominik Barthelme; Robert T Sauer
Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine.
Science (New York, N.Y.) 2012;337(6096):843-6.
2012: Steven E Glynn; Andrew R Nager; Tania A Baker; Robert T Sauer
Dynamic and static components power unfolding in topologically closed rings of a AAA+ proteolytic machine.
Nature structural & molecular biology 2012;19(6):616-22.
2012: Seokhee Kim; Robert T Sauer
Cage assembly of DegP protease is not required for substrate-dependent regulation of proteolytic activity or high-temperature cell survival.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(19):7263-8.
2012: Shankar Sundar; Tania A Baker; Robert T Sauer
The I domain of the AAA+ HslUV protease coordinates substrate binding, ATP hydrolysis, and protein degradation.
Protein science : a publication of the Protein Society 2012;21(2):188-98.
2011: Joseph H Davis; Tania A Baker; Robert T Sauer
Small-molecule control of protein degradation using split adaptors.
ACS chemical biology 2011;6(11):1205-13.
2011: Andrew R Nager; Tania A Baker; Robert T Sauer
Stepwise unfolding of a β barrel protein by the AAA+ ClpXP protease.
Journal of molecular biology 2011;413(1):4-16.
2011: Giselle Román-Hernández; Robert T Sauer; Robert A Grant; Jennifer Y Hou; Tania A Baker
The ClpS adaptor mediates staged delivery of N-end rule substrates to the AAA+ ClpAP protease.
Molecular cell 2011;43(2):217-28.
2011: Robert T Sauer; Tania A Baker
AAA+ proteases: ATP-fueled machines of protein destruction.
Annual review of biochemistry 2011;80():587-612.
2011: Marie-Eve Aubin-Tam; Adrian O Olivares; Robert T Sauer; Tania A Baker; Matthew J Lang
Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine.
Cell 2011;145(2):257-67.
2011: Seokhee Kim; Robert A Grant; Robert T Sauer
Covalent linkage of distinct substrate degrons controls assembly and disassembly of DegP proteolytic cages.
Cell 2011;145(1):67-78.
2011: Rachna Chaba; Benjamin M Alba; Monica S Guo; Jungsan Sohn; Nidhi Ahuja; Robert T Sauer; Carol A Gross
Signal integration by DegS and RseB governs the σ E-mediated envelope stress response in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(5):2106-11.
2011: Joseph H Davis; Adam J Rubin; Robert T Sauer
Design, construction and characterization of a set of insulated bacterial promoters.
Nucleic acids research 2011;39(3):1131-41.
2010: Shankar Sundar; Kathleen E McGinness; Tania A Baker; Robert T Sauer
Multiple sequence signals direct recognition and degradation of protein substrates by the AAA+ protease HslUV.
Journal of molecular biology 2010;403(3):420-9.
2010: Jungsan Sohn; Robert A Grant; Robert T Sauer
Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution.
The Journal of biological chemistry 2010;285(44):34039-47.
2010: Mary E Lee; Tania A Baker; Robert T Sauer
Control of substrate gating and translocation into ClpP by channel residues and ClpX binding.
Journal of molecular biology 2010;399(5):707-18.
2010: Sarah A Bissonnette; Izarys Rivera-Rivera; Robert T Sauer; Tania A Baker
The IbpA and IbpB small heat-shock proteins are substrates of the AAA+ Lon protease.
Molecular microbiology 2010;75(6):1539-49.
2010: Aliaa H Abdelhakim; Robert T Sauer; Tania A Baker
The AAA+ ClpX machine unfolds a keystone subunit to remodel the Mu transpososome.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(6):2437-42.
2010: Tahmeena Chowdhury; Peter Chien; Shamsah Ebrahim; Robert T Sauer; Tania A Baker
Versatile modes of peptide recognition by the ClpX N domain mediate alternative adaptor-binding specificities in different bacterial species.
Protein science : a publication of the Protein Society 2010;19(2):242-54.
2009: Yongdae Shin; Joseph H Davis; Ricardo R Brau; Andreas Martin; Jon A Kenniston; Tania A Baker; Robert T Sauer; Matthew J Lang
Single-molecule denaturation and degradation of proteins by the AAA+ ClpXP protease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(46):19340-5.
2009: Steven E Glynn; Andreas Martin; Andrew R Nager; Tania A Baker; Robert T Sauer
Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine.
Cell 2009;139(4):744-56.
2009: Eyal Gur; Robert T Sauer
Degrons in protein substrates program the speed and operating efficiency of the AAA+ Lon proteolytic machine.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(44):18503-8.
2009: Jungsan Sohn; Robert A Grant; Robert T Sauer
OMP peptides activate the DegS stress-sensor protease by a relief of inhibition mechanism.
Structure (London, England : 1993) 2009;17(10):1411-21.
2009: Sarah R Barkow; Igor Levchenko; Tania A Baker; Robert T Sauer
Polypeptide translocation by the AAA+ ClpXP protease machine.
Chemistry & biology 2009;16(6):605-12.
2009: Giselle Román-Hernández; Robert A Grant; Robert T Sauer; Tania A Baker
Molecular basis of substrate selection by the N-end rule adaptor protein ClpS.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(22):8888-93.
2009: Brent O Cezairliyan; Robert T Sauer
Control of Pseudomonas aeruginosa AlgW protease cleavage of MucA by peptide signals and MucB.
Molecular microbiology 2009;72(2):368-79.
2009: Jungsan Sohn; Robert T Sauer
OMP peptides modulate the activity of DegS protease by differential binding to active and inactive conformations.
Molecular cell 2009;33(1):64-74.
2008: Sean D Moore; Robert T Sauer
Revisiting the mechanism of macrolide-antibiotic resistance mediated by ribosomal protein L22.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18261-6.
2008: Kevin H Wang; Giselle Roman-Hernandez; Robert A Grant; Robert T Sauer; Tania A Baker
The molecular basis of N-end rule recognition.
Molecular cell 2008;32(3):406-14.
2008: Andreas Martin; Tania A Baker; Robert T Sauer
Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding.
Nature structural & molecular biology 2008;15(11):1147-51.
2008: Eyal Gur; Robert T Sauer
Evolution of the ssrA degradation tag in Mycoplasma: specificity switch to a different protease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(42):16113-8.
2008: Kevin H Wang; Elizabeth S C Oakes; Robert T Sauer; Tania A Baker
Tuning the strength of a bacterial N-end rule degradation signal.
The Journal of biological chemistry 2008;283(36):24600-7.
2008: Sean D Moore; Tania A Baker; Robert T Sauer
Forced extraction of targeted components from complex macromolecular assemblies.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11685-90.
2008: Eyal Gur; Robert T Sauer
Recognition of misfolded proteins by Lon, a AAA(+) protease.
Genes & development 2008;22(16):2267-77.
2008: Joseph A Yakamavich; Tania A Baker; Robert T Sauer
Asymmetric nucleotide transactions of the HslUV protease.
Journal of molecular biology 2008;380(5):946-57.
2008: Aliaa H Abdelhakim; Elizabeth C Oakes; Robert T Sauer; Tania A Baker
Unique contacts direct high-priority recognition of the tetrameric Mu transposase-DNA complex by the AAA+ unfoldase ClpX.
Molecular cell 2008;30(1):39-50.
2008: Andreas Martin; Tania A Baker; Robert T Sauer
Diverse pore loops of the AAA+ ClpX machine mediate unassisted and adaptor-dependent recognition of ssrA-tagged substrates.
Molecular cell 2008;29(4):441-50.
2007: Jungsan Sohn; Robert A Grant; Robert T Sauer
Allosteric activation of DegS, a stress sensor PDZ protease.
Cell 2007;131(3):572-83.
2007: Peter Chien; Robert A Grant; Robert T Sauer; Tania A Baker
Structure and substrate specificity of an SspB ortholog: design implications for AAA+ adaptors.
Structure (London, England : 1993) 2007;15(10):1296-305.
2007: Andreas Martin; Tania A Baker; Robert T Sauer
Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease.
Molecular cell 2007;27(1):41-52.
2007: Peter Chien; Barrett S Perchuk; Michael T Laub; Robert T Sauer; Tania A Baker
Direct and adaptor-mediated substrate recognition by an essential AAA+ protease.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6590-5.
2007: Kathleen E McGinness; Daniel N. Bolon; Mark Kaganovich; Tania A Baker; Robert T Sauer
Altered tethering of the SspB adaptor to the ClpXP protease causes changes in substrate delivery.
The Journal of biological chemistry 2007;282(15):11465-73.
2007: Brent O Cezairliyan; Robert T Sauer
Inhibition of regulated proteolysis by RseB.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3771-6.
2007: Kevin H Wang; Robert T Sauer; Tania A Baker
ClpS modulates but is not essential for bacterial N-end rule degradation.
Genes & development 2007;21(4):403-8.
2007: Christopher M Farrell; Tania A Baker; Robert T Sauer
Altered specificity of a AAA+ protease.
Molecular cell 2007;25(1):161-6.
2007: Sean D Moore; Robert T Sauer
The tmRNA system for translational surveillance and ribosome rescue.
Annual review of biochemistry 2007;76():101-24.
2006: Tania A Baker; Robert T Sauer
ATP-dependent proteases of bacteria: recognition logic and operating principles.
Trends in biochemical sciences 2006;31(12):647-53.
2006: Kathleen E McGinness; Tania A Baker; Robert T Sauer
Engineering controllable protein degradation.
Molecular cell 2006;22(5):701-7.
2006: Saskia B Neher; Judit Villén; Elizabeth C Oakes; Corey E Bakalarski; Robert T Sauer; Steven P Gygi; Tania A Baker
Proteomic profiling of ClpXP substrates after DNA damage reveals extensive instability within SOS regulon.
Molecular cell 2006;22(2):193-204.
2005: Thomas A Anderson; Matthew H J Cordes; Robert T Sauer
Sequence determinants of a conformational switch in a protein structure.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18344-9.
2005: Andreas Martin; Tania A Baker; Robert T Sauer
Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines.
Nature 2005;437(7062):1115-20.
2005: Sean D Moore; Robert T Sauer
Ribosome rescue: tmRNA tagging activity and capacity in Escherichia coli.
Molecular microbiology 2005;58(2):456-66.
2005: Daniel N. Bolon; Robert A Grant; Tania A Baker; Robert T Sauer
Specificity versus stability in computational protein design.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(36):12724-9.
2005: Christopher M Farrell; Alan D Grossman; Robert T Sauer
Cytoplasmic degradation of ssrA-tagged proteins.
Molecular microbiology 2005;57(6):1750-61.
2005: Greg L Hersch; Randall E Burton; Daniel N. Bolon; Tania A Baker; Robert T Sauer
Asymmetric interactions of ATP with the AAA+ ClpX6 unfoldase: allosteric control of a protein machine.
Cell 2005;121(7):1017-27.
2005: Igor Levchenko; Robert A Grant; Julia M Flynn; Robert T Sauer; Tania A Baker
Versatile modes of peptide recognition by the AAA+ adaptor protein SspB.
Nature structural & molecular biology 2005;12(6):520-5.
2005: Randall E Burton; Tania A Baker; Robert T Sauer
Nucleotide-dependent substrate recognition by the AAA+ HslUV protease.
Nature structural & molecular biology 2005;12(3):245-51.
2005: Ramon K Tabtiang; Brent O Cezairliyan; Robert A Grant; Jesse C Cochrane; Robert T Sauer
Consolidating critical binding determinants by noncyclic rearrangement of protein secondary structure.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2305-9.
2005: Jon A Kenniston; Tania A Baker; Robert T Sauer
Partitioning between unfolding and release of native domains during ClpXP degradation determines substrate selectivity and partial processing.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1390-5.
2004: Daniel N. Bolon; Robert A Grant; Tania A Baker; Robert T Sauer
Nucleotide-dependent substrate handoff from the SspB adaptor to the AAA+ ClpXP protease.
Molecular cell 2004;16(3):343-50.
2004: Robert T Sauer; Daniel N. Bolon; Briana M Burton; Randall E Burton; Julia M Flynn; Robert A Grant; Greg L Hersch; Shilpa A Joshi; Jon A Kenniston; Igor Levchenko; Saskia B Neher; Elizabeth S C Oakes; Samia M Siddiqui; David A Wah; Tania A Baker
Sculpting the proteome with AAA(+) proteases and disassembly machines.
Cell 2004;119(1):9-18.
2004: Julia M Flynn; Igor Levchenko; Robert T Sauer; Tania A Baker
Modulating substrate choice: the SspB adaptor delivers a regulator of the extracytoplasmic-stress response to the AAA+ protease ClpXP for degradation.
Genes & development 2004;18(18):2292-301.
2004: Kathleen E McGinness; Robert T Sauer
Ribosomal protein S1 binds mRNA and tmRNA similarly but plays distinct roles in translation of these molecules.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(37):13454-9.
2004: Jon A Kenniston; Robert T Sauer
Signaling degradation.
Nature structural & molecular biology 2004;11(9):800-2.
2004: Greg L Hersch; Tania A Baker; Robert T Sauer
SspB delivery of substrates for ClpXP proteolysis probed by the design of improved degradation tags.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(33):12136-41.
2004: Shari Spector; Robert T Sauer; Bruce Tidor
Computational and experimental probes of symmetry mismatches in the Arc repressor-DNA complex.
Journal of molecular biology 2004;340(2):253-61.
2004: Shilpa A Joshi; Greg L Hersch; Tania A Baker; Robert T Sauer
Communication between ClpX and ClpP during substrate processing and degradation.
Nature structural & molecular biology 2004;11(5):404-11.
2004: Jon A Kenniston; Randall E Burton; Samia M Siddiqui; Tania A Baker; Robert T Sauer
Effects of local protein stability and the geometric position of the substrate degradation tag on the efficiency of ClpXP denaturation and degradation.
Journal of structural biology 2004;146(1-2):130-40.
2004: Samia M Siddiqui; Robert T Sauer; Tania A Baker
Role of the processing pore of the ClpX AAA+ ATPase in the recognition and engagement of specific protein substrates.
Genes & development 2004;18(4):369-74.
2004: Daniel N. Bolon; David A Wah; Greg L Hersch; Tania A Baker; Robert T Sauer
Bivalent tethering of SspB to ClpXP is required for efficient substrate delivery: a protein-design study.
Molecular cell 2004;13(3):443-9.
2003: Shari Spector; Julia M Flynn; Bruce Tidor; Tania A Baker; Robert T Sauer
Expression of N-formylated proteins in Escherichia coli.
Protein expression and purification 2003;32(2):317-22.
2003: Saskia B Neher; Robert T Sauer; Tania A Baker
Distinct peptide signals in the UmuD and UmuD' subunits of UmuD/D' mediate tethering and substrate processing by the ClpXP protease.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13219-24.
2003: Christopher S Hayes; Robert T Sauer
Cleavage of the A site mRNA codon during ribosome pausing provides a mechanism for translational quality control.
Molecular cell 2003;12(4):903-11.
2003: Eric Schreiter; Michael D Sintchak; Yayi Guo; Peter T Chivers; Robert T Sauer; Catherine L Drennan
Crystal structure of the nickel-responsive transcription factor NikR.
Nature structural biology 2003;10(10):794-9.
2003: Jon A Kenniston; Tania A Baker; Julio M Fernandez; Robert T Sauer
Linkage between ATP consumption and mechanical unfolding during the protein processing reactions of an AAA+ degradation machine.
Cell 2003;114(4):511-20.
2003: Igor Levchenko; Robert A Grant; David A Wah; Robert T Sauer; Tania A Baker
Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag.
Molecular cell 2003;12(2):365-72.
2003: David A Wah; Igor Levchenko; Gabrielle E Rieckhof; Daniel N. Bolon; Tania A Baker; Robert T Sauer
Flexible linkers leash the substrate binding domain of SspB to a peptide module that stabilizes delivery complexes with the AAA+ ClpXP protease.
Molecular cell 2003;12(2):355-63.
2003: Saskia B Neher; Julia M Flynn; Robert T Sauer; Tania A Baker
Latent ClpX-recognition signals ensure LexA destruction after DNA damage.
Genes & development 2003;17(9):1084-9.
2003: Randall E Burton; Tania A Baker; Robert T Sauer
Energy-dependent degradation: Linkage between ClpX-catalyzed nucleotide hydrolysis and protein-substrate processing.
Protein science : a publication of the Protein Society 2003;12(5):893-902.
2003: Nathan P Walsh; Benjamin M Alba; Baundauna Bose; Carol A Gross; Robert T Sauer
OMP peptide signals initiate the envelope-stress response by activating DegS protease via relief of inhibition mediated by its PDZ domain.
Cell 2003;113(1):61-71.
2003: Sean D Moore; Kathleen E McGinness; Robert T Sauer
Structural biology. A glimpse into tmRNA-mediated ribosome rescue.
Science (New York, N.Y.) 2003;300(5616):72-3.
2003: Shilpa A Joshi; Tania A Baker; Robert T Sauer
C-terminal domain mutations in ClpX uncouple substrate binding from an engagement step required for unfolding.
Molecular microbiology 2003;48(1):67-76.
2003: Julia M Flynn; Saskia B Neher; Yong In Kim; Robert T Sauer; Tania A Baker
Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals.
Molecular cell 2003;11(3):671-83.
2003: Matthew H J Cordes; Nathan P Walsh; C James McKnight; Robert T Sauer
Solution structure of switch Arc, a mutant with 3(10) helices replacing a wild-type beta-ribbon.
Journal of molecular biology 2003;326(3):899-909.
2003: Paul E Carrington; Peter T Chivers; Faizah Al-Mjeni; Robert T Sauer; Michael Maroney
Nickel coordination is regulated by the DNA-bound state of NikR.
Nature structural biology 2003;10(2):126-30.
2003: Christopher S Hayes; Robert T Sauer
Toxin-antitoxin pairs in bacteria: killers or stress regulators?
Cell 2003;112(1):2-4.
2003: Thomas A Anderson; Robert T Sauer
Role of an N(cap) residue in determining the stability and operator-binding affinity of Arc repressor.
Biophysical chemistry 2003;100(1-3):341-50.
2002: Alok K Srivastava; Robert T Sauer
Mutational studies of protein stability and folding of the hyperstable MYL Arc repressor variant.
Biophysical chemistry 2002;101-102():35-42.
2002: David A Wah; Igor Levchenko; Tania A Baker; Robert T Sauer
Characterization of a specificity factor for an AAA+ ATPase: assembly of SspB dimers with ssrA-tagged proteins and the ClpX hexamer.
Chemistry & biology 2002;9(11):1237-45.
2002: Peter T Chivers; Robert T Sauer
NikR repressor: high-affinity nickel binding to the C-terminal domain regulates binding to operator DNA.
Chemistry & biology 2002;9(10):1141-8.
2002: Christopher S Hayes; Baundauna Bose; Robert T Sauer
Proline residues at the C terminus of nascent chains induce SsrA tagging during translation termination.
The Journal of biological chemistry 2002;277(37):33825-32.
2002: Christopher S Hayes; Baundauna Bose; Robert T Sauer
Stop codons preceded by rare arginine codons are efficient determinants of SsrA tagging in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3440-5.
2001: Sharief Barends; AW Karzai; Robert T Sauer; Jacek Wower; Barend Kraal
Simultaneous and functional binding of SmpB and EF-Tu-TP to the alanyl acceptor arm of tmRNA.
Journal of molecular biology 2001;314(1):9-21.
2001: Julia M Flynn; Igor Levchenko; M Seidel; Sue Wickner; Robert T Sauer; Tania A Baker
Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10584-9.
2001: E D Roche; Robert T Sauer
Identification of endogenous SsrA-tagged proteins reveals tagging at positions corresponding to stop codons.
The Journal of biological chemistry 2001;276(30):28509-15.
2001: Randall E Burton; Samia M Siddiqui; Yong In Kim; Tania A Baker; Robert T Sauer
Effects of protein stability and structure on substrate processing by the ClpXP unfolding and degradation machine.
The EMBO journal 2001;20(12):3092-100.
2001: M J Nohaile; Zachary S Hendsch; Bruce Tidor; Robert T Sauer
Altering dimerization specificity by changes in surface electrostatics.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3109-14.
2001: AW Karzai; Robert T Sauer
Protein factors associated with the SsrA.SmpB tagging and ribosome rescue complex.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3040-4.
2001: J H Lo; Tania A Baker; Robert T Sauer
Characterization of the N-terminal repeat domain of Escherichia coli ClpA-A class I Clp/HSP100 ATPase.
Protein science : a publication of the Protein Society 2001;10(3):551-9.
2001: Yong In Kim; Igor Levchenko; K Fraczkowska; R V Woodruff; Robert T Sauer; Tania A Baker
Molecular determinants of complex formation between Clp/Hsp100 ATPases and the ClpP peptidase.
Nature structural biology 2001;8(3):230-3.
2001: A Berggrun; Robert T Sauer
Contributions of distinct quaternary contacts to cooperative operator binding by Mnt repressor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2301-5.
2001: Zachary S Hendsch; M J Nohaile; Robert T Sauer; Bruce Tidor
Preferential heterodimer formation via undercompensated electrostatic interactions.
Journal of the American Chemical Society 2001;123(6):1264-5.
2000: Matthew H J Cordes; Randall E Burton; Nathan P Walsh; C James McKnight; Robert T Sauer
An evolutionary bridge to a new protein fold.
Nature structural biology 2000;7(12):1129-32.
2000: Clifford R Robinson; Robert T Sauer
Striking stabilization of Arc repressor by an engineered disulfide bond.
Biochemistry 2000;39(40):12494-502.
2000: Igor Levchenko; M Seidel; Robert T Sauer; Tania A Baker
A specificity-enhancing factor for the ClpXP degradation machine.
Science (New York, N.Y.) 2000;289(5488):2354-6.
2000: A Berggrun; Robert T Sauer
Interactions of Arg2 in the Mnt N-terminal arm with the central and flanking regions of the Mnt operator.
Journal of molecular biology 2000;301(4):959-73.
2000: A K Srivastava; Robert T Sauer
Evidence for partial secondary structure formation in the transition state for arc repressor refolding and dimerization.
Biochemistry 2000;39(28):8308-14.
2000: Peter T Chivers; Robert T Sauer
Regulation of high affinity nickel uptake in bacteria. Ni2+-Dependent interaction of NikR with wild-type and mutant operator sites.
The Journal of biological chemistry 2000;275(26):19735-41.
2000: AW Karzai; E D Roche; Robert T Sauer
The SsrA-SmpB system for protein tagging, directed degradation and ribosome rescue.
Nature structural biology 2000;7(6):449-55.
2000: Yong In Kim; Randall E Burton; Briana M Burton; Robert T Sauer; Tania A Baker
Dynamics of substrate denaturation and translocation by the ClpXP degradation machine.
Molecular cell 2000;5(4):639-48.
1999: Peter T Chivers; Robert T Sauer
NikR is a ribbon-helix-helix DNA-binding protein.
Protein science : a publication of the Protein Society 1999;8(11):2494-500.
1999: E D Roche; Robert T Sauer
SsrA-mediated peptide tagging caused by rare codons and tRNA scarcity.
The EMBO journal 1999;18(16):4579-89.
1999: AW Karzai; M M Susskind; Robert T Sauer
SmpB, a unique RNA-binding protein essential for the peptide-tagging activity of SsrA (tmRNA).
The EMBO journal 1999;18(13):3793-9.
1999: Ehud Gazit; Robert T Sauer
The Doc toxin and Phd antidote proteins of the bacteriophage P1 plasmid addiction system form a heterotrimeric complex.
The Journal of biological chemistry 1999;274(24):16813-8.
1999: C K Smith; Tania A Baker; Robert T Sauer
Lon and Clp family proteases and chaperones share homologous substrate-recognition domains.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6678-82.
1999: Dionisios Rentzeperis; T Jonsson; Robert T Sauer
Acceleration of the refolding of Arc repressor by nucleic acids and other polyanions.
Nature structural biology 1999;6(6):569-73.
1999: Matthew H J Cordes; Nathan P Walsh; C James McKnight; Robert T Sauer
Evolution of a protein fold in vitro.
Science (New York, N.Y.) 1999;284(5412):325-8.
1999: B M Brown; Robert T Sauer
Tolerance of Arc repressor to multiple-alanine substitutions.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):1983-8.
1999: J F Schildbach; AW Karzai; B E Raumann; Robert T Sauer
Origins of DNA-binding specificity: role of protein contacts with the DNA backbone.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(3):811-7.
1999: Matthew H J Cordes; Robert T Sauer
Tolerance of a protein to multiple polar-to-hydrophobic surface substitutions.
Protein science : a publication of the Protein Society 1999;8(2):318-25.
1999: Ehud Gazit; Robert T Sauer
Stability and DNA binding of the phd protein of the phage P1 plasmid addiction system.
The Journal of biological chemistry 1999;274(5):2652-7.
1998: Clifford R Robinson; Robert T Sauer
Optimizing the stability of single-chain proteins by linker length and composition mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):5929-34.
1998: J F Schildbach; Clifford R Robinson; Robert T Sauer
Biophysical characterization of the TraY protein of Escherichia coli F factor.
The Journal of biological chemistry 1998;273(3):1329-33.
1997: Igor Levchenko; C K Smith; Nathan P Walsh; Robert T Sauer; Tania A Baker
PDZ-like domains mediate binding specificity in the Clp/Hsp100 family of chaperones and protease regulatory subunits.
Cell 1997;91(7):939-47.
1997: Clifford R Robinson; Dionisios Rentzeperis; Jerson L Silva; Robert T Sauer
Formation of a denatured dimer limits the thermal stability of Arc repressor.
Journal of molecular biology 1997;273(3):692-700.
1997: L Tucker-Kellogg; MA Rould; K A Chambers; S E Ades; Robert T Sauer; Carl O Pabo
Engrailed (Gln50-->Lys) homeodomain-DNA complex at 1.9 A resolution: structural basis for enhanced affinity and altered specificity.
Structure (London, England : 1993) 1997;5(8):1047-54.
1996: T L Smith; Robert T Sauer
Role of operator subsites in Arc repression.
Journal of molecular biology 1996;264(2):233-42.
1996: Clifford R Robinson; Robert T Sauer
Equilibrium stability and sub-millisecond refolding of a designed single-chain Arc repressor.
Biochemistry 1996;35(44):13878-84.
1996: C D Waldburger; Robert T Sauer
Signal detection by the PhoQ sensor-transmitter. Characterization of the sensor domain and a response-impaired mutant that identifies ligand-binding determinants.
The Journal of biological chemistry 1996;271(43):26630-6.
1996: H Kolmar; P R Waller; Robert T Sauer
The DegP and DegQ periplasmic endoproteases of Escherichia coli: specificity for cleavage sites and substrate conformation.
Journal of bacteriology 1996;178(20):5925-9.
1996: T L Smith; Robert T Sauer
Dual regulation of open-complex formation and promoter clearance by Arc explains a novel repressor to activator switch.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):8868-72.
1996: Zachary S Hendsch; T Jonsson; Robert T Sauer; Bruce Tidor
Protein stabilization by removal of unsatisfied polar groups: computational approaches and experimental tests.
Biochemistry 1996;35(24):7621-5.
1996: T Jonsson; C D Waldburger; Robert T Sauer
Nonlinear free energy relationships in Arc repressor unfolding imply the existence of unstable, native-like folding intermediates.
Biochemistry 1996;35(15):4795-802.
1996: C D Waldburger; T Jonsson; Robert T Sauer
Barriers to protein folding: formation of buried polar interactions is a slow step in acquisition of structure.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):2629-34.
1996: Kenneth Keiler; P R Waller; Robert T Sauer
Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA.
Science (New York, N.Y.) 1996;271(5251):990-3.
1996: Kenneth Keiler; Robert T Sauer
Sequence determinants of C-terminal substrate recognition by the Tsp protease.
The Journal of biological chemistry 1996;271(5):2589-93.
1996: M H Cordes; A R Davidson; Robert T Sauer
Sequence space, folding and protein design.
Current opinion in structural biology 1996;6(1):3-10.
1996: P R Waller; Robert T Sauer
Characterization of degQ and degS, Escherichia coli genes encoding homologs of the DegP protease.
Journal of bacteriology 1996;178(4):1146-53.
1996: Clifford R Robinson; Robert T Sauer
Covalent attachment of Arc repressor subunits by a peptide linker enhances affinity for operator DNA.
Biochemistry 1996;35(1):109-16.
1996: Robert T Sauer; M E Milla; C D Waldburger; B M Brown; J F Schildbach
Sequence determinants of folding and stability for the P22 Arc repressor dimer.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(1):42-8.
1995: B E Raumann; K L Knight; Robert T Sauer
Dramatic changes in DNA-binding specificity caused by single residue substitutions in an Arc/Mnt hybrid repressor.
Nature structural biology 1995;2(12):1115-22.
1995: Kenneth Keiler; Robert T Sauer
Identification of active site residues of the Tsp protease.
The Journal of biological chemistry 1995;270(48):28864-8.
1995: S E Ades; Robert T Sauer
Specificity of minor-groove and major-groove interactions in a homeodomain-DNA complex.
Biochemistry 1995;34(44):14601-8.
1995: M E Milla; B M Brown; C D Waldburger; Robert T Sauer
P22 Arc repressor: transition state properties inferred from mutational effects on the rates of protein unfolding and refolding.
Biochemistry 1995;34(42):13914-9.
1995: C D Waldburger; Robert T Sauer
Domains of Mnt repressor: roles in tetramer formation, protein stability, and operator DNA binding.
Biochemistry 1995;34(40):13109-16.
1995: A R Davidson; Kevin J Lumb; Robert T Sauer
Cooperatively folded proteins in random sequence libraries.
Nature structural biology 1995;2(10):856-64.
1995: Kenneth Keiler; K R Silber; K M Downard; Ioannis Papayannopoulos; Klaus Biemann; Robert T Sauer
C-terminal specific protein degradation: activity and substrate specificity of the Tsp protease.
Protein science : a publication of the Protein Society 1995;4(8):1507-15.
1995: T L Smith; Robert T Sauer
P22 Arc repressor: role of cooperativity in repression and binding to operators with altered half-site spacing.
Journal of molecular biology 1995;249(4):729-42.
1995: M E Milla; Robert T Sauer
Critical side-chain interactions at a subunit interface in the Arc repressor dimer.
Biochemistry 1995;34(10):3344-51.
1995: C D Waldburger; J F Schildbach; Robert T Sauer
Are buried salt bridges important for protein stability and conformational specificity?
Nature structural biology 1995;2(2):122-8.
1995: J F Schildbach; M E Milla; Philip Jeffrey; B E Raumann; Robert T Sauer
Crystal structure, folding, and operator binding of the hyperstable Arc repressor mutant PL8.
Biochemistry 1995;34(4):1405-12.
1994: Susan Marqusee; Robert T Sauer
Contributions of a hydrogen bond/salt bridge network to the stability of secondary and tertiary structure in lambda repressor.
Protein science : a publication of the Protein Society 1994;3(12):2217-25.
1994: S E Ades; Robert T Sauer
Differential DNA-binding specificity of the engrailed homeodomain: the role of residue 50.
Biochemistry 1994;33(31):9187-94.
1994: M E Milla; B M Brown; Robert T Sauer
Protein stability effects of a complete set of alanine substitutions in Arc repressor.
Nature structural biology 1994;1(8):518-23.
1994: D S Waugh; Robert T Sauer
A novel class of FokI restriction endonuclease mutants that cleave hemi-methylated substrates.
The Journal of biological chemistry 1994;269(16):12298-303.
1994: A R Davidson; Robert T Sauer
Folded proteins occur frequently in libraries of random amino acid sequences.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2146-50.
1994: B M Brown; M E Milla; T L Smith; Robert T Sauer
Scanning mutagenesis of the Arc repressor as a functional probe of operator recognition.
Nature structural biology 1994;1(3):164-8.
1994: B E Raumann; MA Rould; Carl O Pabo; Robert T Sauer
DNA recognition by beta-sheets in the Arc repressor-operator crystal structure.
Nature 1994;367(6465):754-7.
1994: M E Milla; Robert T Sauer
P22 Arc repressor: folding kinetics of a single-domain, dimeric protein.
Biochemistry 1994;33(5):1125-33.
1994: K R Silber; Robert T Sauer
Deletion of the prc (tsp) gene provides evidence for additional tail-specific proteolytic activity in Escherichia coli K-12.
Molecular & general genetics : MGG 1994;242(2):237-40.
1993: M E Milla; B M Brown; Robert T Sauer
P22 Arc repressor: enhanced expression of unstable mutants by addition of polar C-terminal sequences.
Protein science : a publication of the Protein Society 1993;2(12):2198-205.
1993: D S Waugh; Robert T Sauer
Single amino acid substitutions uncouple the DNA binding and strand scission activities of Fok I endonuclease.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9596-600.
1993: J C Hu; N E Newell; Bruce Tidor; Robert T Sauer
Probing the roles of residues at the e and g positions of the GCN4 leucine zipper by combinatorial mutagenesis.
Protein science : a publication of the Protein Society 1993;2(7):1072-84.
1993: Lydia Gregoret; Robert T Sauer
Additivity of mutant effects assessed by binomial mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4246-50.
1993: B M Brown; Robert T Sauer
Assembly of the Arc repressor-operator complex: cooperative interactions between DNA-bound dimers.
Biochemistry 1993;32(5):1354-63.
1992: Wendell A Lim; D C Farruggio; Robert T Sauer
Structural and energetic consequences of disruptive mutations in a protein core.
Biochemistry 1992;31(17):4324-33.
1992: K L Knight; Robert T Sauer
Biochemical and genetic analysis of operator contacts made by residues within the beta-sheet DNA binding motif of Mnt repressor.
The EMBO journal 1992;11(1):215-23.
1992: K R Silber; Kenneth Keiler; Robert T Sauer
Tsp: a tail-specific protease that selectively degrades proteins with nonpolar C termini.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):295-9.
1992: Carl O Pabo; Robert T Sauer
Transcription factors: structural families and principles of DNA recognition.
Annual review of biochemistry 1992;61():1053-95.
1991: Wendell A Lim; Robert T Sauer
The role of internal packing interactions in determining the structure and stability of a protein.
Journal of molecular biology 1991;219(2):359-76.
1991: M C Mossing; J U Bowie; Robert T Sauer
A streptomycin selection for DNA-binding activity.
Methods in enzymology 1991;208():604-19.
1991: John Reidhaar-Olson; J U Bowie; R M Breyer; J C Hu; K L Knight; Wendell A Lim; M C Mossing; D A Parsell; K R Shoemaker; Robert T Sauer
Random mutagenesis of protein sequences using oligonucleotide cassettes.
Methods in enzymology 1991;208():564-86.
1990: B M Brown; J U Bowie; Robert T Sauer
Arc repressor is tetrameric when bound to operator DNA.
Biochemistry 1990;29(51):11189-95.
1990: M C Mossing; Robert T Sauer
Stable, monomeric variants of lambda Cro obtained by insertion of a designed beta-hairpin sequence.
Science (New York, N.Y.) 1990;250(4988):1712-5.
1990: J C Hu; E K O'Shea; Peter S Kim; Robert T Sauer
Sequence requirements for coiled-coils: analysis with lambda repressor-GCN4 leucine zipper fusions.
Science (New York, N.Y.) 1990;250(4986):1400-3.
1990: John Reidhaar-Olson; D A Parsell; Robert T Sauer
An essential proline in lambda repressor is required for resistance to intracellular proteolysis.
Biochemistry 1990;29(33):7563-71.
1990: A A Pakula; Robert T Sauer
Reverse hydrophobic effects relieved by amino-acid substitutions at a protein surface.
Nature 1990;344(6264):363-4.
1990: J U Bowie; John Reidhaar-Olson; Wendell A Lim; Robert T Sauer
Deciphering the message in protein sequences: tolerance to amino acid substitutions.
Science (New York, N.Y.) 1990;247(4948):1306-10.
1990: D A Parsell; K R Silber; Robert T Sauer
Carboxy-terminal determinants of intracellular protein degradation.
Genes & development 1990;4(2):277-86.
1990: J U Bowie; Robert T Sauer
TraY proteins of F and related episomes are members of the Arc and Mnt repressor family.
Journal of molecular biology 1990;211(1):5-6.
1990: John Reidhaar-Olson; Robert T Sauer
Functionally acceptable substitutions in two alpha-helical regions of lambda repressor.
Proteins 1990;7(4):306-16.
1990: J U Bowie; Neil D Clarke; Carl O Pabo; Robert T Sauer
Identification of protein folds: matching hydrophobicity patterns of sequence sets with solvent accessibility patterns of known structures.
Proteins 1990;7(3):257-64.
1989: M G Zagorski; J U Bowie; A K Vershon; Robert T Sauer; Dinshaw J Patel
NMR studies of Arc repressor mutants: proton assignments, secondary structure, and long-range contacts for the thermostable proline-8----leucine variant of Arc.
Biochemistry 1989;28(25):9813-25.
1989: J U Bowie; Robert T Sauer
Equilibrium dissociation and unfolding of the Arc repressor dimer.
Biochemistry 1989;28(18):7139-43.
1989: K L Knight; Robert T Sauer
Identification of functionally important residues in the DNA binding region of the mnt repressor.
The Journal of biological chemistry 1989;264(23):13706-10.
1989: R M Breyer; Robert T Sauer
Mutational analysis of the fine specificity of binding of monoclonal antibody 51F to lambda repressor.
The Journal of biological chemistry 1989;264(22):13355-60.
1989: R M Breyer; Robert T Sauer
Production and characterization of monoclonal antibodies to the N-terminal domain of lambda repressor.
The Journal of biological chemistry 1989;264(22):13348-54.
1989: D A Parsell; Robert T Sauer
Induction of a heat shock-like response by unfolded protein in Escherichia coli: dependence on protein level not protein degradation.
Genes & development 1989;3(8):1226-32.
1989: J U Bowie; Robert T Sauer
Identification of C-terminal extensions that protect proteins from intracellular proteolysis.
The Journal of biological chemistry 1989;264(13):7596-602.
1989: D A Parsell; Robert T Sauer
The structural stability of a protein is an important determinant of its proteolytic susceptibility in Escherichia coli.
The Journal of biological chemistry 1989;264(13):7590-5.
1989: Wendell A Lim; Robert T Sauer
Alternative packing arrangements in the hydrophobic core of lambda repressor.
Nature 1989;339(6219):31-6.
1989: J U Bowie; Robert T Sauer
Identifying determinants of folding and activity for a protein of unknown structure.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2152-6.
1989: K L Knight; J U Bowie; A K Vershon; R D Kelley; Robert T Sauer
The Arc and Mnt repressors. A new class of sequence-specific DNA-binding protein.
The Journal of biological chemistry 1989;264(7):3639-42.
1989: F S Gimble; Robert T Sauer
Lambda repressor mutants that are better substrates for RecA-mediated cleavage.
Journal of molecular biology 1989;206(1):29-39.
1989: A K Vershon; R D Kelley; Robert T Sauer
Sequence-specific binding of arc repressor to DNA. Effects of operator mutations and modifications.
The Journal of biological chemistry 1989;264(6):3267-73.
1989: K L Knight; Robert T Sauer
DNA binding specificity of the Arc and Mnt repressors is determined by a short region of N-terminal residues.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):797-801.
1989: A A Pakula; Robert T Sauer
Amino acid substitutions that increase the thermal stability of the lambda Cro protein.
Proteins 1989;5(3):202-10.
1988: John Reidhaar-Olson; Robert T Sauer
Combinatorial cassette mutagenesis as a probe of the informational content of protein sequences.
Science (New York, N.Y.) 1988;241(4861):53-7.
1988: K L Knight; Robert T Sauer
The Mnt repressor of bacteriophage P22: role of C-terminal residues in operator binding and tetramer formation.
Biochemistry 1988;27(6):2088-94.
1987: M A Weiss; M Karplus; Robert T Sauer
Quaternary structure and function in phage lambda repressor: 1H-NMR studies of genetically altered proteins.
Journal of biomolecular structure & dynamics 1987;5(3):539-56.
1987: A K Vershon; S M Liao; WR McClure; Robert T Sauer
Interaction of the bacteriophage P22 Arc repressor with operator DNA.
Journal of molecular biology 1987;195(2):323-31.
1987: A K Vershon; S M Liao; WR McClure; Robert T Sauer
Bacteriophage P22 Mnt repressor. DNA binding and effects on transcription in vitro.
Journal of molecular biology 1987;195(2):311-22.
1986: A K Vershon; J U Bowie; T M Karplus; Robert T Sauer
Isolation and analysis of arc repressor mutants: evidence for an unusual mechanism of DNA binding.
Proteins 1986;1(4):302-11.
1986: Michael H Hecht; Julian M Sturtevant; Robert T Sauer
Stabilization of lambda repressor against thermal denaturation by site-directed Gly----Ala changes in alpha-helix 3.
Proteins 1986;1(1):43-6.
1986: A R Poteete; K Hehir; Robert T Sauer
Bacteriophage P22 Cro protein: sequence, purification, and properties.
Biochemistry 1986;25(1):251-6.
1985: Michael H Hecht; K M Hehir; H C Nelson; Julian M Sturtevant; Robert T Sauer
Increasing and decreasing protein stability: effects of revertant substitutions on the thermal denaturation of phage lambda repressor.
Journal of cellular biochemistry 1985;29(3):217-24.
1983: Robert T Sauer; H C Nelson; K Hehir; Michael H Hecht; F S Gimble; J DeAnda; A R Poteete
The lambda and P22 phage repressors.
Journal of biomolecular structure & dynamics 1983;1(4):1011-22.
1983: Michael H Hecht; H C Nelson; Robert T Sauer
Mutations in lambda repressor's amino-terminal domain: implications for protein stability and DNA binding.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(9):2676-80.
1983: H C Nelson; Michael H Hecht; Robert T Sauer
Mutations defining the operator-binding sites of bacteriophage lambda repressor.
Cold Spring Harbor symposia on quantitative biology 1983;47 Pt 1():441-9.
1981: Robert T Sauer; J Pan; P Hopper; K Hehir; J Brown; A R Poteete
Primary structure of the phage P22 repressor and its gene c2.
Biochemistry 1981;20(12):3591-8.