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Willi Sauerbrei

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Harald Binder; Willi Sauerbrei; Patrick Royston
Comparison between splines and fractional polynomials for multivariable model building with continuous covariates: a simulation study with continuous response.
Willi Sauerbrei; Patrick Royston
A new strategy for meta-analysis of continuous covariates in observational studies.
Willi Sauerbrei; Anne-Laure Boulesteix; Harald Binder
Stability investigations of multivariable regression models derived from low- and high-dimensional data.

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All Publications

2013: Harald Binder; Willi Sauerbrei; Patrick Royston
Comparison between splines and fractional polynomials for multivariable model building with continuous covariates: a simulation study with continuous response.
Statistics in medicine 2013;32(13):2262-77.
2011: Willi Sauerbrei; Patrick Royston
A new strategy for meta-analysis of continuous covariates in observational studies.
Statistics in medicine 2011;30(28):3341-60.
2011: Willi Sauerbrei; Anne-Laure Boulesteix; Harald Binder
Stability investigations of multivariable regression models derived from low- and high-dimensional data.
Journal of biopharmaceutical statistics 2011;21(6):1206-31.
2011: Willi Sauerbrei; Patrick Royston; Martin Schumacher
Comments on 'Performance of using multiple stepwise algorithms for variable selection' by Ryan E. Wiegand, Statistics in Medicine 2010; 29:1647-1659.
Statistics in medicine 2011;30(8):892-4; author reply 894-5.
2010: Harald Binder; Willi Sauerbrei
Adding local components to global functions for continuous covariates in multivariable regression modeling.
Statistics in medicine 2010;29(7-8):808-17.
2010: R Stollhoff; Willi Sauerbrei; Martin Schumacher
An experimental evaluation of boosting methods for classification.
Methods of information in medicine 2010;49(3):219-29.
2010: Klaus-Jürgen Winzer; Willi Sauerbrei; M Braun; T Liersch; J Dunst; Hans Guski; Martin Schumacher
Radiation therapy and tamoxifen after breast-conserving surgery: updated results of a 2 x 2 randomised clinical trial in patients with low risk of recurrence.
European journal of cancer (Oxford, England : 1990) 2010;46(1):95-101.
2009: Willi Sauerbrei; Maria Blettner
Interpreting results in 2 x 2 tables: part 9 of a series on evaluation of scientific publications.
Deutsches Ärzteblatt international 2009;106(48):795-800.
2007: Willi Sauerbrei; Patrick Royston; Harald Binder
Selection of important variables and determination of functional form for continuous predictors in multivariable model building.
Statistics in medicine 2007;26(30):5512-28.
2007: Willi Sauerbrei; Patrick Royston
Modelling to extract more information from clinical trials data: On some roles for the bootstrap.
Statistics in medicine 2007;26(27):4989-5001.
2007: Willi Sauerbrei; Patrick Royston; Maxime Look
A new proposal for multivariable modelling of time-varying effects in survival data based on fractional polynomial time-transformation.
Biometrical journal. Biometrische Zeitschrift 2007;49(3):453-73.
2006: Patrick Royston; Douglas Altman; Willi Sauerbrei
Dichotomizing continuous predictors in multiple regression: a bad idea.
Statistics in medicine 2006;25(1):127-41.
2006: Norbert Holländer; N H Augustin; Willi Sauerbrei
Investigation on the improvement of prediction by bootstrap model averaging.
Methods of information in medicine 2006;45(1):44-50.
2005: Patrick Royston; Willi Sauerbrei
Building multivariable regression models with continuous covariates in clinical epidemiology--with an emphasis on fractional polynomials.
Methods of information in medicine 2005;44(4):561-71.
2005: Willi Sauerbrei
Prognostic factors. Confusion caused by bad quality design, analysis and reporting of many studies.
Advances in oto-rhino-laryngology 2005;62():184-200.
2004: Patrick Royston; Willi Sauerbrei
A new approach to modelling interactions between treatment and continuous covariates in clinical trials by using fractional polynomials.
Statistics in medicine 2004;23(16):2509-25.
2004: Norbert Holländer; Willi Sauerbrei; Martin Schumacher
Confidence intervals for the effect of a prognostic factor after selection of an 'optimal' cutpoint.
Statistics in medicine 2004;23(11):1701-13.
2004: Klaus-Jürgen Winzer; R Sauer; Willi Sauerbrei; E Schneller; W Jaeger; M Braun; J Dunst; T Liersch; M Zedelius; K Brunnert; Hans Guski; Claudia Schmoor; Martin Schumacher
Radiation therapy after breast-conserving surgery; first results of a randomised clinical trial in patients with low risk of recurrence.
European journal of cancer (Oxford, England : 1990) 2004;40(7):998-1005.
2004: Dirk Watermann; Helmut Madjar; Willi Sauerbrei; Valerie Hirt; Heinrich Prömpeler; Elmar Stickeler
Assessment of breast cancer vascularisation by Doppler ultrasound as a prognostic factor of survival.
Oncology reports 2004;11(4):905-10.
2004: Patrick Royston; Willi Sauerbrei
A new measure of prognostic separation in survival data.
Statistics in medicine 2004;23(5):723-48.
2004: Patrick Royston; Willi Sauerbrei; A Ritchie
Is treatment with interferon-alpha effective in all patients with metastatic renal carcinoma? A new approach to the investigation of interactions.
British journal of cancer 2004;90(4):794-9.
2003: Patrick Royston; Willi Sauerbrei
Stability of multivariable fractional polynomial models with selection of variables and transformations: a bootstrap investigation.
Statistics in medicine 2003;22(4):639-59.
2002: Marco Colleoni; H J Litman; Monica Castiglione-Gertsch; Willi Sauerbrei; Richard D Gelber; Marco Bonetti; Alan Coates; M Schumacher; G Bastert; Carl-Magnus Rudenstam; Claudia Schmoor; Jurij Lindtner; John Collins; Beat Thürlimann; Stig B Holmberg; Diana Crivellari; C Beyerle; R L A Neumann; Aron Goldhirsch
Duration of adjuvant chemotherapy for breast cancer: a joint analysis of two randomised trials investigating three versus six courses of CMF.
British journal of cancer 2002;86(11):1705-14.
2002: Dirk G Kieback; Dagmar-C Fischer; Dirk G Engehausen; Willi Sauerbrei; Martin K. Oehler; Xiao-Wen Tong; Estuardo Aguilar-Cordova
Intraperitoneal adenovirus-mediated suicide gene therapy in combination with either topotecan or paclitaxel in nude mice with human ovarian cancer.
Cancer gene therapy 2002;9(5):478-81.
2002: Claudia Schmoor; M Olschewski; Willi Sauerbrei; Martin Schumacher
Long-term follow-up of patients in four prospective studies of the German Breast Cancer Study Group (GBSG): A summary of key results.
Onkologie 2002;25(2):143-50.
2002: B Randelzhofer; Heinrich Prömpeler; Willi Sauerbrei; Helmut Madjar; Günter Emons
Value of sonomorphological criteria of the endometrium in women with postmenopausal bleeding: a multivariate analysis.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 2002;19(1):62-8.
2001: Claudia Schmoor; Willi Sauerbrei; G Bastert; H Bojar; M Schumacher
Long-term prognosis of breast cancer patients with 10 or more positive lymph nodes treated with CMF.
European journal of cancer (Oxford, England : 1990) 2001;37(9):1123-31.
2000: Claudia Schmoor; G Bastert; J Dunst; H Bojar; D Christmann; V Unbehaun; G Tümmers; W Bauer; Willi Sauerbrei; M Schumacher
Randomized trial on the effect of radiotherapy in addition to 6 cycles CMF in node-positive breast-cancer patients. The German Breast-Cancer Study Group.
International journal of cancer. Journal international du cancer 2000;86(3):408-15.
2000: Claudia Schmoor; Willi Sauerbrei; G Bastert; M Schumacher
Role of isolated locoregional recurrence of breast cancer: results of four prospective studies.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(8):1696-708.
2000: Claudia Schmoor; Willi Sauerbrei; Martin Schumacher
Sample size considerations for the evaluation of prognostic factors in survival analysis.
Statistics in medicine 2000;19(4):441-52.
2000: Willi Sauerbrei; G Bastert; H Bojar; C Beyerle; R L Neumann; Claudia Schmoor; M Schumacher
Randomized 2 x 2 trial evaluating hormonal treatment and the duration of chemotherapy in node-positive breast cancer patients: an update based on 10 years' follow-up. German Breast Cancer Study Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(1):94-101.
1999: Patrick Royston; Gareth Ambler; Willi Sauerbrei
The use of fractional polynomials to model continuous risk variables in epidemiology.
International journal of epidemiology 1999;28(5):964-74.
1999: E Graf; Claudia Schmoor; Willi Sauerbrei; Martin Schumacher
Assessment and comparison of prognostic classification schemes for survival data.
Statistics in medicine 1999;18(17-18):2529-45.
1999: Willi Sauerbrei; Patrick Royston; H Bojar; Claudia Schmoor; M Schumacher
Modelling the effects of standard prognostic factors in node-positive breast cancer. German Breast Cancer Study Group (GBSG).
British journal of cancer 1999;79(11-12):1752-60.
1998: Willi Sauerbrei; Helmut Madjar; Heinrich Prömpeler
Differentiation of benign and malignant breast tumors by logistic regression and a classification tree using Doppler flow signals.
Methods of information in medicine 1998;37(3):226-34.
1998: Willi Sauerbrei; M Blettner; Claudia Schmoor; H Bojar; M Schumacher
The effect of oral contraceptive use on the prognosis of node positive breast cancer patients. German Breast Cancer Study Group.
European journal of cancer (Oxford, England : 1990) 1998;34(9):1348-51.
1998: Gabi Schulgen; Claudia Schmoor; Willi Sauerbrei; Martin Schumacher
A note on estimating local recurrence rates in clinical trials on the treatment of breast cancer.
Breast cancer research and treatment 1998;49(1):87-91.
1998: HF Rauschecker; Willi Sauerbrei; W Gatzemeier; Rolf Sauer; A Schauer; Claudia Schmoor; Martin Schumacher
Eight-year results of a prospective non-randomised study on therapy of small breast cancer. The German Breast Cancer Study Group (GBSG).
European journal of cancer (Oxford, England : 1990) 1998;34(3):315-23.
1997: Martin Schumacher; Norbert Holländer; Willi Sauerbrei
Resampling and cross-validation techniques: a tool to reduce bias caused by model building?
Statistics in medicine 1997;16(24):2813-27.
1997: Hans-Gerd Meerpohl; Willi Sauerbrei; H Kühnle; Martin Schumacher; A Pfleiderer
Randomized study comparing carboplatin/cyclophosphamide and cisplatin/cyclophosphamide as first-line treatment in patients with stage III/IV epithelial ovarian cancer and small volume disease. German Ovarian Cancer Study Group (GOCA).
Gynecologic oncology 1997;66(1):75-84.
1997: Helmut Madjar; Willi Sauerbrei; Heinrich Prömpeler; R Wolfarth; Hubert Gufler
Color Doppler and duplex flow analysis for classification of breast lesions.
Gynecologic oncology 1997;64(3):392-403.
1997: Heinrich Prömpeler; Helmut Madjar; Willi Sauerbrei; U Lattermann; A Pfleiderer
Diagnostic formula for the differentiation of adnexal tumors by transvaginal sonography.
Obstetrics and gynecology 1997;89(3):428-33.
1997: Willi Sauerbrei; K Hübner; Claudia Schmoor; Martin Schumacher
Validation of existing and development of new prognostic classification schemes in node negative breast cancer. German Breast Cancer Study Group.
Breast cancer research and treatment 1997;42(2):149-63.
1996: Willi Sauerbrei; Maria Blettner; M Schumacher
Re: Meta-analysis comparing cisplatin total dose intensity and survival: a critical reappraisal.
Gynecologic oncology 1996;62(3):427-9.
1996: Heinrich Prömpeler; Helmut Madjar; Willi Sauerbrei; U Lattermann; A Pfleiderer
[Combined evaluation of ovarian tumors with transvaginal B-image and color Doppler ultrasound].
Geburtshilfe und Frauenheilkunde 1996;56(7):345-50.
1996: Heinrich Prömpeler; Helmut Madjar; Willi Sauerbrei
Classification of adnexal tumors by transvaginal color Doppler.
Gynecologic oncology 1996;61(3):354-63.
1996: H Ikenberg; I Wiegering; Jacobus Pfisterer; M Kiechle-Schwarz; B Schmitt; Willi Sauerbrei; A Pfleiderer
Human papillomavirus DNA in tumor-free regional lymph nodes: a potential prognostic marker in cervical carcinoma.
The cancer journal from Scientific American 1996;2(1):28-34.
1995: Jacobus Pfisterer; Friedrich Kommoss; Willi Sauerbrei; D Menzel; Marion Kiechle; E Giese; M Hilgarth; A Pfleiderer
DNA flow cytometry in node-positive breast cancer. Prognostic value and correlation with morphologic and clinical factors.
Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 1995;17(6):406-12.
1995: Helmut Madjar; Heinrich Prömpeler; Willi Sauerbrei; A Mundinger; A Pfleiderer
Differential diagnosis of breast lesions by color Doppler.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 1995;6(3):199-204.
1995: Jacobus Pfisterer; Friedrich Kommoss; Willi Sauerbrei; I Rendl; Marion Kiechle; W Kleine; A Pfleiderer
Prognostic value of DNA ploidy and S-phase fraction in stage I endometrial carcinoma.
Gynecologic oncology 1995;58(2):149-56.
1995: Wolfram Jäger; Willi Sauerbrei
Effect of timing of surgery during the menstrual cycle of premenopausal breast cancer patients.
Breast cancer research and treatment 1995;34(3):279-87.
1994: H Ikenberg; Willi Sauerbrei; U Schottmüller; C Spitz; A Pfleiderer
Human papillomavirus DNA in cervical carcinoma--correlation with clinical data and influence on prognosis.
International journal of cancer. Journal international du cancer 1994;59(3):322-6.
1994: Jacobus Pfisterer; Friedrich Kommoss; Willi Sauerbrei; H Renz; Andreas du Bois; M Kiechle-Schwarz; A Pfleiderer
Cellular DNA content and survival in advanced ovarian carcinoma.
Cancer 1994;74(9):2509-15.
1994: Friedrich Kommoss; J Wölfle; Thomas Bauknecht; Jacobus Pfisterer; M Kiechle-Schwarz; A Pfleiderer; Willi Sauerbrei; R Kiehl; Barry M Kacinski
Co-expression of M-CSF transcripts and protein, FMS (M-CSF receptor) transcripts and protein, and steroid receptor content in adenocarcinomas of the ovary.
The Journal of pathology 1994;174(2):111-9.
1994: M Schumacher; G Bastert; H Bojar; K Hübner; Manfred Olschewski; Willi Sauerbrei; Claudia Schmoor; C Beyerle; R L Neumann; HF Rauschecker
Randomized 2 x 2 trial evaluating hormonal treatment and the duration of chemotherapy in node-positive breast cancer patients. German Breast Cancer Study Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(10):2086-93.
1994: Willi Sauerbrei; G Bastert; Claudia Schmoor
Prognostic effect of timing of surgery during menstrual cycle in premenopausal breast-cancer patients. German Breast Cancer Study Group.
International journal of cancer. Journal international du cancer 1994;59(1):149-50.
1994: Heinrich Prömpeler; Helmut Madjar; Willi Sauerbrei; U Lattermann; A Pfleiderer
Quantitative flow measurements for classification of ovarian tumors by transvaginal color Doppler sonography in postmenopausal patients.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 1994;4(5):406-13.
1994: Friedrich Kommoss; Jacobus Pfisterer; T Idris; E Giese; Willi Sauerbrei; W Schäfer; M Thome; A Pfleiderer
Steroid receptors in carcinoma of the breast. Results of immunocytochemical and biochemical determination and their effects on short-term prognosis.
Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 1994;16(3):203-10.
1994: Heinrich Prömpeler; Helmut Madjar; Willi Sauerbrei; U Lattermann; Andreas du Bois; M Breckwoldt; A Pfleiderer
[Transvaginal color-coded Doppler ultrasound in ovarian tumors].
Geburtshilfe und Frauenheilkunde 1994;54(4):216-21.
1994: Helmut Madjar; Heinrich Prömpeler; Willi Sauerbrei; R Wolfarth; A Pfleiderer
Color Doppler flow criteria of breast lesions.
Ultrasound in medicine & biology 1994;20(9):849-58.
1993: Maria Blettner; Willi Sauerbrei
Influence of model-building strategies on the results of a case-control study.
Statistics in medicine 1993;12(14):1325-38.
1993: M Heinrich Seegenschmiedt; Willi Sauerbrei; Rolf Sauer; M Schumacher; A Schauer; HF Rauschecker; H Dinkloh; E Dühmke; K D Haase; W Haase
Quality control review for radiotherapy of small breast cancer: analysis of 708 patients in the GBSG I trial. German Breast Study Group (GBSG).
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 1993;169(6):339-50.
1993: Helmut Madjar; H A Ladner; Willi Sauerbrei; A Oberstein; Heinrich Prömpeler; A Pfleiderer
Preoperative staging of breast cancer by palpation, mammography and high-resolution ultrasound.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 1993;3(3):185-90.
1993: Martin Schumacher; Claudia Schmoor; Willi Sauerbrei; A Schauer; L Ummenhofer; W Gatzemeier; HF Rauschecker
The prognostic effect of histological tumor grade in node-negative breast cancer patients.
Breast cancer research and treatment 1993;25(3):235-45.
1992: Friedrich Kommoss; Jacobus Pfisterer; M Thome; W Schäfer; Willi Sauerbrei; A Pfleiderer
Steroid receptors in ovarian carcinoma: immunohistochemical determination may lead to new aspects.
Gynecologic oncology 1992;47(3):317-22.
1992: Willi Sauerbrei; Martin Schumacher
A bootstrap resampling procedure for model building: application to the Cox regression model.
Statistics in medicine 1992;11(16):2093-109.
1992: HF Rauschecker; W Gatzemeier; Rolf Sauer; M Heinrich Seegenschmiedt; A Schauer; L Ummenhofer; Willi Sauerbrei; Claudia Schmoor; M Schumacher
[Initial results of the Project of the German Breast Cancer Study Group on "Breast saving therapy of the small breast cancer"].
Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen 1992;63(6):495-500.
1992: Rolf Sauer; A Schauer; HF Rauschecker; M Schumacher; W Gatzemeier; Willi Sauerbrei; Jürgen Dunst; M Heinrich Seegenschmiedt; D Marx
Breast preservation versus mastectomy in early breast cancer--1991 update of the GBSG 1--protocol and prognostic factors. The German Breast Cancer Study Group.
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 1992;168(4):191-202.
1991: Helmut Madjar; Willi Sauerbrei; S Münch; H Schillinger
Continuous-wave and pulsed Doppler studies of the breast: clinical results and effect of transducer frequency.
Ultrasound in medicine & biology 1991;17(1):31-9.
1990: Helmut Madjar; Willi Sauerbrei; S Münch; Heinrich Prömpeler; H Schillinger
[Analysis of a method for Doppler study of the female breast].
Ultraschall in der Medizin (Stuttgart, Germany : 1980) 1990;11(4):196-201.
1990: Helmut Madjar; S Münch; Willi Sauerbrei; M Bauer; H Schillinger
[Differential breast diagnosis using CW-Doppler ultrasound].
Der Radiologe 1990;30(4):193-7.