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Axel Sauerbrey

Research Profile

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TOP 3
Daniela Laux; Christian Kratz; Axel Sauerbrey
Common acute lymphoblastic leukemia in a girl with genetically confirmed LEOPARD syndrome.
Thomas Efferth; Badireenath Konkimalla; Yi-Fen Wang; Axel Sauerbrey; Silke Meinhardt; Felix Zintl; Jürgen Mattern; Manfred Volm
Prediction of broad spectrum resistance of tumors towards anticancer drugs.
Sabine Wagner; Ove Peters; Christin Fels; Gisela Janssen; Anne-Kathrin Liebeskind; Axel Sauerbrey; Meinolf Suttorp; Peter Hau; Johannes Ernst Wolff
Pegylated-liposomal doxorubicin and oral topotecan in eight children with relapsed high-grade malignant brain tumors.

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All Publications

2008: Daniela Laux; Christian Kratz; Axel Sauerbrey
Common acute lymphoblastic leukemia in a girl with genetically confirmed LEOPARD syndrome.
Journal of pediatric hematology/oncology 2008;30(8):602-4.
2008: Thomas Efferth; Badireenath Konkimalla; Yi-Fen Wang; Axel Sauerbrey; Silke Meinhardt; Felix Zintl; Jürgen Mattern; Manfred Volm
Prediction of broad spectrum resistance of tumors towards anticancer drugs.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(8):2405-12.
2008: Sabine Wagner; Ove Peters; Christin Fels; Gisela Janssen; Anne-Kathrin Liebeskind; Axel Sauerbrey; Meinolf Suttorp; Peter Hau; Johannes Ernst Wolff
Pegylated-liposomal doxorubicin and oral topotecan in eight children with relapsed high-grade malignant brain tumors.
Journal of neuro-oncology 2008;86(2):175-81.
2006: Thomas Efferth; Jean-Pierre Gillet; Axel Sauerbrey; Felix Zintl; Vincent Bertholet; Françoise de Longueville; José Remacle; Daniel Steinbach
Expression profiling of ATP-binding cassette transporters in childhood T-cell acute lymphoblastic leukemia.
Molecular cancer therapeutics 2006;5(8):1986-94.
2006: Daniel Steinbach; Jean-Pierre Gillet; Axel Sauerbrey; Bernd Gruhn; Kristin Dawczynski; Vincent Bertholet; Françoise de Longueville; Felix Zintl; José Remacle; Thomas Efferth
ABCA3 as a possible cause of drug resistance in childhood acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 1):4357-63.
2006: Claus Doerfel; Andreas Rump; Axel Sauerbrey; Bernd Gruhn; Felix Zintl; Daniel Steinbach
In acute leukemia, the polymorphism -211C>T in the promoter region of the multidrug resistance-associated protein 3 (MRP3) does not determine the expression level of the gene.
Pharmacogenetics and genomics 2006;16(2):149-50.
2005: Daniel Steinbach; Jana Friedrich; Kristin Dawczynski; Silke Furchtbar; Bernd Gruhn; Susann Wittig; Felix Zintl; Axel Sauerbrey
Are MTT assays the right tool to analyze drug resistance caused by ABC-transporters in patient samples?
Leukemia & lymphoma 2005;46(9):1357-63.
2003: Daniel Steinbach; Susann Wittig; Gunnar Cario; Susanne Viehmann; Angelika Mueller; Bernd Gruhn; Ralf Haefer; Felix Zintl; Axel Sauerbrey
The multidrug resistance-associated protein 3 (MRP3) is associated with a poor outcome in childhood ALL and may account for the worse prognosis in male patients and T-cell immunophenotype.
Blood 2003;102(13):4493-8.
2003: Anita Heller; Vladimir Trifonov; Nikolai Rubtsov; Axel Sauerbrey; Heike Starke; Ivan F Loncarevic; Uwe Claussen; Thomas Liehr
Complex chromosomal rearrangements in a secondary acute myeloblastic leukemia after chemotherapy in TRAPS.
Oncology reports 2003;10(6):1789-92.
2003: Thomas Efferth; Erich Gebhart; Douglas Ross; Axel Sauerbrey
Identification of gene expression profiles predicting tumor cell response to L-alanosine.
Biochemical pharmacology 2003;66(4):613-21.
2003: Thomas Efferth; Axel Sauerbrey; Armin Olbrich; Erich Gebhart; Pia Rauch; H Oliver Weber; Jan G Hengstler; Marc-Eric Halatsch; Manfred Volm; Kenneth D Tew; Douglas Ross; Jens Oliver Funk
Molecular modes of action of artesunate in tumor cell lines.
Molecular pharmacology 2003;64(2):382-94.
2003: Thomas Efferth; Axel Sauerbrey; Daniel Steinbach; Erich Gebhart; Hans-Günther Drexler; Hayato Miyachi; Christopher R Chitambar; Cord-Michael Becker; Felix Zintl; Andreas Humeny
Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia.
International journal of oncology 2003;23(2):509-17.
2003: Lutz Hempel; Axel Sauerbrey; Felix Zintl; Angela Weirich; Andreas Lemmer; Norbert Graf
Successful management of a child with clear cell sarcoma of the kidney (CCSK) and multifocal bone metastases at diagnosis.
Medical and pediatric oncology 2003;41(1):97-9.
2003: Daniel Steinbach; Janka Lengemann; Astrid Voigt; Johann Hermann; Felix Zintl; Axel Sauerbrey
Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2, MRP3, MRP4, MRP5, and SMRP in childhood acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(3):1083-6.
2003: Daniel Steinbach; S Furchtbar; Wieland Sell; Janka Lengemann; Johann Hermann; Felix Zintl; Axel Sauerbrey
Contrary to adult patients, expression of the multidrug resistance gene (MDR1) fails to define a poor prognostic group in childhood AML.
Leukemia 2003;17(2):470-1.
2003: Thomas Efferth; Axel Sauerbrey; Marc-Eric Halatsch; Douglas Ross; Erich Gebhart
Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines.
Naunyn-Schmiedeberg's archives of pharmacology 2003;367(1):56-67.
2002: Thomas Efferth; Armin Olbrich; Axel Sauerbrey; Douglas Ross; Erich Gebhart; Michael Neugebauer
Activity of ascaridol from the anthelmintic herb Chenopodium anthelminticum L. against sensitive and multidrug-resistant tumor cells.
Anticancer research 2002;22(6C):4221-4.
2002: Manfred Volm; Axel Sauerbrey; F Zintl; Reet Koomägi; Thomas Efferth
Protein expression profile of newly diagnosed acute lymphoblastic leukemia in children developing relapses.
Oncology reports 2002;9(5):965-9.
2002: Daniel Steinbach; Wieland Sell; Astrid Voigt; Johann Hermann; Felix Zintl; Axel Sauerbrey
BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia.
Leukemia 2002;16(8):1443-7.
2002: Thomas Efferth; Irmgard Verdorfer; Hayato Miyachi; Axel Sauerbrey; Hans G Drexler; Christopher R Chitambar; Michelle Haber; Erich Gebhart
Genomic imbalances in drug-resistant T-cell acute lymphoblastic CEM leukemia cell lines.
Blood cells, molecules & diseases 2002;29(1):1-13.
2002: Axel Sauerbrey; Wieland Sell; Daniel Steinbach; Astrid Voigt; Felix Zintl
Expression of the BCRP gene (ABCG2/MXR/ABCP) in childhood acute lymphoblastic leukaemia.
British journal of haematology 2002;118(1):147-50.
2002: Axel Sauerbrey; Astrid Voigt; Susann Wittig; Ralf Häfer; Felix Zintl
Messenger RNA analysis of the multidrug resistance related protein (MRP1) and the lung resistance protein (LRP) in de novo and relapsed childhood acute lymphoblastic leukemia.
Leukemia & lymphoma 2002;43(4):875-9.
2002: Jill Brown; mays jawad; Stephen R F Twigg; Kaan Saracoglu; Axel Sauerbrey; Angela E Thomas; Roland Eils; Jochen Harbott; Lyndal Kearney
A cryptic t(5;11)(q35;p15.5) in 2 children with acute myeloid leukemia with apparently normal karyotypes, identified by a multiplex fluorescence in situ hybridization telomere assay.
Blood 2002;99(7):2526-31.
2002: Hans-Joachim Mentzel; Karim Kentouche; Hartwig Kosmehl; Bernd Gruhn; Susanna Vogt; Axel Sauerbrey; Werner Behrendt; Dietlinde Fuchs; Felix Zintl; Werner A Kaiser
US and MRI of gastrointestinal graft-versus-host disease.
Pediatric radiology 2002;32(3):195-8.
2001: R Koomagi; Felix Zintl; Axel Sauerbrey; Manfred Volm
Vascular endothelial growth factor in newly diagnosed and recurrent childhood acute lymphoblastic leukemia as measured by real-time quantitative polymerase chain reaction.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(11):3381-4.
2001: Axel Sauerbrey; Stefan S Bielack; Beate Kempf-Bielack; Andreas Zoubek; Michael Paulussen; Felix Zintl
High-dose chemotherapy (HDC) and autologous hematopoietic stem cell transplantation (ASCT) as salvage therapy for relapsed osteosarcoma.
Bone marrow transplantation 2001;27(9):933-7.
2001: Thomas Efferth; H Dunstan; Axel Sauerbrey; H Miyachi; Christopher R Chitambar
The anti-malarial artesunate is also active against cancer.
International journal of oncology 2001;18(4):767-73.
1999: Manfred Volm; Felix Zintl; Axel Sauerbrey; Reet Koomägi
Proliferation and apoptosis in newly diagnosed and relapsed childhood acute lymphoblastic leukemia.
Anticancer research 1999;19(5B):4327-31.
1999: Manfred Volm; Felix Zintl; Axel Sauerbrey; Reet Koomägi
Expression of Fas ligand in newly diagnosed childhood acute lymphoblastic leukemia.
Anticancer research 1999;19(4C):3399-402.
1999: Axel Sauerbrey; Ralf Häfer; Felix Zintl; M Volm
Analysis of cyclin D1 in de novo and relapsed childhood acute lymphoblastic leukemia.
Anticancer research 1999;19(1B):645-9.
1998: Reet Koomägi; Axel Sauerbrey; Felix Zintl; Manfred Volm
nm23-H1 protein expression in newly diagnosed and relapsed childhood acute lymphoblastic leukemia.
Anticancer research 1998;18(6A):4307-9.
1998: J Hermann; D Fuchs; Axel Sauerbrey; Lutz Hempel; Felix Zintl
Successful treatment of essential thrombocythemia with anagrelide in a child.
Medical and pediatric oncology 1998;30(6):367-70; discussion 370-1.
1998: Axel Sauerbrey; Felix Zintl; J Hermann; M Volm
Multiple resistance mechanisms in acute nonlymphoblastic leukemia (ANLL).
Anticancer research 1998;18(2B):1231-6.
1998: Axel Sauerbrey; Gerd Stammler; Felix Zintl; M Volm
Expression of the retinoblastoma tumor suppressor gene (RB-1) in acute leukemia.
Leukemia & lymphoma 1998;28(3-4):275-83.
1997: Manfred Volm; Reet Koomägi; Gerd Stammler; Werner Rittgen; Felix Zintl; Axel Sauerbrey
Prognostic implications of cyclins (D1, E, A), cyclin-dependent kinases (CDK2, CDK4) and tumor-suppressor genes (pRB, p16INK4A) in childhood acute lymphoblastic leukemia.
International journal of cancer. Journal international du cancer 1997;74(5):508-12.
1997: Manfred Volm; Gerd Stammler; Felix Zintl; Reet Koomägi; Axel Sauerbrey
Expression of lung resistance-related protein (LRP) in initial and relapsed childhood acute lymphoblastic leukemia.
Anti-cancer drugs 1997;8(7):662-5.
1997: Gerd Stammler; Felix Zintl; Axel Sauerbrey; Manfred Volm
Deoxycytidine kinase mRNA expression in childhood acute lymphoblastic leukemia.
Anti-cancer drugs 1997;8(5):517-21.
1997: Manfred Volm; Felix Zintl; L Edler; Axel Sauerbrey
Prognostic value of protein kinase C, proto-oncogene products and resistance-related proteins in newly diagnosed childhood acute lymphoblastic leukemia.
Medical and pediatric oncology 1997;28(2):117-26.
1997: Gerd Stammler; Axel Sauerbrey; Felix Zintl; Manfred Volm
Apoptotic index, Fas and bcl-2 in initial and relapsed childhood acute lymphoblastic leukaemia.
Apoptosis : an international journal on programmed cell death 1997;2(4):377-83.
1996: Axel Sauerbrey; Gerd Stammler; Felix Zintl; M Volm
Expression and prognostic value of the retinoblastoma tumour suppressor gene (RB-1) in childhood acute lymphoblastic leukaemia.
British journal of haematology 1996;94(1):99-104.
1995: Bernd Gruhn; D Fuchs; J Hermann; J Prager; Axel Sauerbrey; Felix Zintl
[Therapy-induced formation of ascites and pleural effusion during initial chemotherapy in a patient with non-Hodgkin's lymphoma. Ascites and pleural effusion during initial chemotherapy].
Klinische Pädiatrie 1995;207(6):317-20.
1995: Axel Sauerbrey; M Volm; Felix Zintl
[Expression and clinical significance of resistance proteins in initial acute lymphatic leukemia (ALL) in childhood].
Klinische Pädiatrie 1995;207(4):230-4.
1995: Manfred Volm; S Hecker; Axel Sauerbrey; Jürgen Mattern
Predictive value of statin, a G0-associated cell cycle protein, in childhood acute lymphoblastic leukemia.
International journal of cancer. Journal international du cancer 1995;64(3):166-70.
1995: Jürgen Mattern; Axel Sauerbrey; Manfred Volm
p53 protein detected by two different antibodies: relationship to proliferation and prognosis in acute lymphoblastic leukemia.
Anticancer research 1995;15(3):1043-7.
1995: Gerd Stammler; Axel Sauerbrey; Manfred Volm
Messenger RNA expression of resistance factors and their correlation to the proliferative activity in childhood acute lymphoblastic leukemia.
Cancer letters 1995;89(1):129-35.
1994: Axel Sauerbrey; F Zintl; M Volm
P-glycoprotein and glutathione S-transferase pi in childhood acute lymphoblastic leukaemia.
British journal of cancer 1994;70(6):1144-9.
1994: S Hecker; Axel Sauerbrey; Manfred Volm
p53 expression and poor prognosis in childhood acute lymphoblastic leukemia.
Anticancer research 1994;14(6B):2759-61.
1994: Gerd Stammler; Axel Sauerbrey; Manfred Volm
Determination of DNA topoisomerase II in newly diagnosed childhood acute lymphoblastic leukemia by immunocytochemistry and RT-PCR.
Cancer letters 1994;84(2):141-7.
1994: Axel Sauerbrey; Felix Zintl; Manfred Volm
Expression of metallothionein in initial and relapsed childhood acute lymphoblastic leukemia.
Annals of hematology 1994;69(3):111-5.
1994: Manfred Volm; Axel Sauerbrey; Felix Zintl
Dihydrofolate-reductase and thymidylate-synthase in childhood acute lymphoblastic leukemia.
Anticancer research 1994;14(3B):1377-81.
1994: Manfred Volm; Felix Zintl; Axel Sauerbrey
Thymidylate synthase in childhood acute non-lymphoblastic leukemia.
Anticancer research 1994;14(3B):1271-5.
1992: J Prager; A Baumert; W Thilo; J Hermann; D Fuchs; Axel Sauerbrey; Felix Zintl
[The kinetics of vaccine antibodies against tetanus toxoid, diphtheria toxoid, measles virus, poliomyelitis virus and pneumococcus after allogeneic and autologous bone marrow transplantation and revaccination. 3: The kinetics of vaccine antibodies against tetanus toxoid and diphtheria toxoid after allogeneic and autologous bone marrow transplantation and combined revaccination against diphtheria and tetanus].
Kinderärztliche Praxis 1992;60(8):230-8.
1989: Felix Zintl; J Prager; Axel Sauerbrey; G Metzner; J Hermann; D Fuchs
Immunoreconstitution after human bone marrow transplantation.
Folia haematologica (Leipzig, Germany : 1928) 1989;116(3-4):519-26.
1989: Axel Sauerbrey; Ralf Häfer; Felix Zintl
[Acute lymphatic leukemia with pre-B-cell characteristics].
Folia haematologica (Leipzig, Germany : 1928) 1989;116(2):219-26.