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Robert Sauerwein

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Else M Bijker; Quirijn de Mast; Wouter Graumans; Cornelus C Hermsen; Annemieke Jansens; Wiebke Nahrendorf; Edmond J Remarque; Will Roeffen; Anja Scholzen; Rianne Siebelink-Stoter; Karina Teelen; Anne C Teirlinck; Marga van de Vegte-Bolmer; André J A M van der Ven; Geert-Jan van Gemert; Lisette van Lieshout; Ben C L van Schaijk; Jaco J Verweij; Martijn Vos; Jorien Wiersma; Dunja Zimmerman; Theo Arens; Guido J H Bastiaens; Robert W Sauerwein
Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity.
Anja Scholzen; Robert W Sauerwein
How malaria modulates memory: activation and dysregulation of B cells in Plasmodium infection.
Anne C Teirlinck; Marga van de Vegte-Bolmer; Geert-Jan van Gemert; Lisette van Lieshout; Leo G Visser; Martijn W Vos; Anja Scholzen; Rianne Siebelink-Stoter; B Kim Lee Sim; Karina Teelen; Steffen Borrmann; Marianne A A Erkens; Wouter Graumans; Moniek J L Heinrichs; Cornelus C Hermsen; Stephen L Hoffman; Adrian J F Luty; Krystelle Nganou-Makamdop; Meta Roestenberg; Yolanda P A Rozier; Robert W Sauerwein
NF135.C10: a new Plasmodium falciparum clone for controlled human malaria infections.

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All Publications

2013: Else M Bijker; Quirijn de Mast; Wouter Graumans; Cornelus C Hermsen; Annemieke Jansens; Wiebke Nahrendorf; Edmond J Remarque; Will Roeffen; Anja Scholzen; Rianne Siebelink-Stoter; Karina Teelen; Anne C Teirlinck; Marga van de Vegte-Bolmer; André J A M van der Ven; Geert-Jan van Gemert; Lisette van Lieshout; Ben C L van Schaijk; Jaco J Verweij; Martijn Vos; Jorien Wiersma; Dunja Zimmerman; Theo Arens; Guido J H Bastiaens; Robert W Sauerwein
Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(19):7862-7.
2013: Anja Scholzen; Robert W Sauerwein
How malaria modulates memory: activation and dysregulation of B cells in Plasmodium infection.
Trends in parasitology 2013;29(5):252-62.
2013: Anne C Teirlinck; Marga van de Vegte-Bolmer; Geert-Jan van Gemert; Lisette van Lieshout; Leo G Visser; Martijn W Vos; Anja Scholzen; Rianne Siebelink-Stoter; B Kim Lee Sim; Karina Teelen; Steffen Borrmann; Marianne A A Erkens; Wouter Graumans; Moniek J L Heinrichs; Cornelus C Hermsen; Stephen L Hoffman; Adrian J F Luty; Krystelle Nganou-Makamdop; Meta Roestenberg; Yolanda P A Rozier; Robert W Sauerwein
NF135.C10: a new Plasmodium falciparum clone for controlled human malaria infections.
The Journal of infectious diseases 2013;207(4):656-60.
2013: Renate C Smallegange; Willem Takken; Marga van de Vegte-Bolmer; Geert-Jan van Gemert; Salvador Gezan; Robert W Sauerwein; James G Logan
Malaria infected mosquitoes express enhanced attraction to human odor.
PloS one 2013;8(5):e63602.
2013: Meta Roestenberg; Robert W Sauerwein; Anja Scholzen; B Kim Lee Sim; Karina Teelen; Anne C Teirlinck; Andre J A M van der Ven; Soundarapandian Velmurugan; Theo Arens; Guido J H Bastiaens; Else M Bijker; Peter F Billingsley; Sumana Chakravarty; Anusha Gunasekera; Cornelus C Hermsen; Eric R James; Stephen L Hoffman
Controlled human malaria infections by intradermal injection of cryopreserved Plasmodium falciparum sporozoites.
The American journal of tropical medicine and hygiene 2013;88(1):5-13.
2012: K Nganou-Makamdop; Ivo Ploemen; Meta Roestenberg; M Behet; Cornelus C Hermsen; Geert-Jan van Gemert; Robert W Sauerwein
Reduced Plasmodium berghei sporozoite liver load associates with low protective efficacy after intradermal immunization.
Parasite immunology 2012;34(12):562-9.
2012: Matthew Laurens; Kirsten E Lyke; Vasee S Moorthy; Christian F Ockenhouse; Thomas L Richie; Meta Roestenberg; Robert W Sauerwein; Michele D Spring; Angela K Talley; Christopher J Duncan; Judith E Epstein; Adrian V Hill; Jack Komisar
A consultation on the optimization of controlled human malaria infection by mosquito bite for evaluation of candidate malaria vaccines.
Vaccine 2012;30(36):5302-4.
2012: Meta Roestenberg; Robert W Sauerwein; Sake J de Vlas; An-Emmie Nieman; Cornelus C Hermsen
Efficacy of preerythrocytic and blood-stage malaria vaccines can be assessed in small sporozoite challenge trials in human volunteers.
The Journal of infectious diseases 2012;206(3):319-23.
2012: J C van Pelt-Koops; Bryan K S Yeung; M van der Vegte-Bolmer; Geert-Jan van Gemert; T T Diagana; W Graumans; H E Pett; M Rottmann; Robert W Sauerwein
The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector.
Antimicrobial agents and chemotherapy 2012;56(7):3544-8.
2012: Else M Bijker; Robert W Sauerwein
Enhancement of naturally acquired immunity against malaria by drug use.
Journal of medical microbiology 2012;61(Pt 7):904-10.
2012: Marta Tibúrcio; Kenneth D Vernick; Pietro Alano; Emmanuel Bischoff; Pierre Buffet; Peter H David; Guillaume Deplaine; Max Hardeman; Ayman Khattab; Odile Mercereau-Puijalon; Geneviève Milon; Papa Alioune Ndour; Makhtar Niang; Sylvie Perrot; Peter R Preiser; Robert W Sauerwein; Francesco Silvestrini; Catherine Lavazec
A switch in infected erythrocyte deformability at the maturation and blood circulation of Plasmodium falciparum transmission stages.
Blood 2012;119(24):e172-80.
2012: Takeshi Annoura; Severine Chevalley-Maurel; Jean-François Franetich; Blandine M D Franke-Fayard; Audrey Gego; Cornelus C Hermsen; Stephen L Hoffman; Chris J Janse; Dominique Mazier; Ivo H J Ploemen; Mohammed Sajid; Robert W Sauerwein; Geert-Jan van Gemert; Ben C L van Schaijk; Martijn W Vos; Shahid M Khan
Assessing the adequacy of attenuation of genetically modified malaria parasite vaccine candidates.
Vaccine 2012;30(16):2662-70.
2012: Ivo H J Ploemen; Huib J Croes; Cornelus C Hermsen; Geert-Jan van Gemert; Mietske Wijers-Rouw; Robert W Sauerwein
Plasmodium berghei Δp52&p36 parasites develop independent of a parasitophorous vacuole membrane in Huh-7 liver cells.
PloS one 2012;7(12):e50772.
2012: Sophie Jones; Robert W Sauerwein; Colin J Sutherland; Karina Teelen; Marga van der Vegte-Bolmer; Patrick H Corran; Chris Drakeley; Rachel Hallett; Cornelus C Hermsen; Theo Arens; Teun Bousema
Filter paper collection of Plasmodium falciparum mRNA for detecting low-density gametocytes.
Malaria journal 2012;11():266.
2012: Meta Roestenberg; Anja Scholzen; Andre J A M van der Ven; Christopher J A Duncan; Nick J Edwards; Judith E Epstein; Cornelus C Hermsen; Adrian V S Hill; Geraldine A O'Hara; Robert W Sauerwein
Comparison of clinical and parasitological data from controlled human malaria infection trials.
PloS one 2012;7(6):e38434.
2012: Krystelle Nganou-Makamdop; Theo Arens; Cornelus C Hermsen; Geert-Jan van Gemert; Robert W Sauerwein
Long term protection after immunization with P. berghei sporozoites correlates with sustained IFNγ responses of hepatic CD8+ memory T cells.
PloS one 2012;7(5):e36508.
2012: Krystelle Nganou-Makamdop; Sandrine A L Audouy; Cornelus C Hermsen; Kees Leenhouts; Geert-Jan van Gemert; Maarten L van Roosmalen; Robert W Sauerwein
Bacterium-like particles as multi-epitope delivery platform for Plasmodium berghei circumsporozoite protein induce complete protection against malaria in mice.
Malaria journal 2012;11():50.
2012: Teun Bousema; Thomas S Churcher; Chris Drakeley; Azra C Ghani; James T Griffin; Robert W Sauerwein; David L Smith; Willem Takken; Roly Gosling
Hitting hotspots: spatial targeting of malaria for control and elimination.
PLoS medicine 2012;9(1):e1001165.
2011: Anne C Teirlinck; Andre J A M van der Ven; Rob Woestenenk; Anja Scholzen; Quirijn de Mast; Cornelus C Hermsen; Adrian J F Luty; Matthew B B McCall; Meta Roestenberg; Robert W Sauerwein
Longevity and composition of cellular immune responses following experimental Plasmodium falciparum malaria infection in humans.
PLoS pathogens 2011;7(12):e1002389.
2011: André Lin Ouédraogo; Will Roeffen; Teun Bousema; Nadine Cuzin-Ouattara; Sake J de Vlas; Edith Ilboudo-Sanogo; Adrian J F Luty; Issa Nebie; Sodiomon B Sirima; Karina Teleen; Alfred B Tiono; Jan Peter Verhave; Robert W Sauerwein
Naturally acquired immune responses to Plasmodium falciparum sexual stage antigens Pfs48/45 and Pfs230 in an area of seasonal transmission.
Infection and immunity 2011;79(12):4957-64.
2011: Meta Roestenberg; Anne C Teirlinck; Matthew B B McCall; Karina Teelen; Krystelle Nganou Makamdop; Jorien Wiersma; Theo Arens; Pieter Beckers; Geert-Jan van Gemert; Marga van de Vegte-Bolmer; Andre J A M van der Ven; Adrian J F Luty; Cornelus C Hermsen; Robert W Sauerwein
Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study.
Lancet 2011;377(9779):1770-6.
2011: Ivo Ploemen; Geert-Jan van Gemert; Marije Behet; Else Bijker; Cornelus C Hermsen; Krystelle Nganou-Makamdop; Robert W Sauerwein
Evaluation of immunity against malaria using luciferase-expressing Plasmodium berghei parasites.
Malaria journal 2011;10():350.
2011: Bruno Douradinha; Chris J Janse; Shahid M Khan; Adrian Jf Luty; Maria M Mota; Robert W Sauerwein; Bruno Silva-Santos; Melissa van Dijk; Geert-Jan van Gemert; Andy P Waters; S Epiphanio
Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver.
Journal of immune based therapies and vaccines 2011;9(1):6.
2011: Laurent Dembele; Audrey Gego; Anne-Marie Zeeman; Jean-François Franetich; Olivier Silvie; Armelle Rametti; Roger Le Grand; Nathalie Dereuddre-Bosquet; Robert W Sauerwein; Geert-Jan van Gemert; Jean-Christophe Vaillant; Alan W Thomas; Georges Snounou; Clemens H M Kocken; Dominique Mazier
Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery.
PloS one 2011;6(3):e18162.
2011: Christine E Farrance; Jessica A Chichester; Konstantin Musiychuk; Moneim Shamloul; Amy Rhee; Slobodanka D Manceva; R Mark Jones; Tarlan Mamedov; Satish Sharma; Vadim Mett; Stephen J Streatfield; Will Roeffen; Marga van de Vegte-Bolmer; Robert W Sauerwein; Yimin Wu; Olga Muratova; Louis H Miller; Patrick Duffy; Robert Sinden; Vidadi Yusibov
Antibodies to plant-produced Plasmodium falciparum sexual stage protein Pfs25 exhibit transmission blocking activity.
Human vaccines 2011;7 Suppl():191-8.
2011: Robert W Sauerwein; Meta Roestenberg; Vasee S Moorthy
Experimental human challenge infections can accelerate clinical malaria vaccine development.
Nature reviews. Immunology 2011;11(1):57-64.
2010: Matthew B B McCall; Meta Roestenberg; Ivo Ploemen; Anne Teirlinck; Jeroen Hopman; Quirijn de Mast; Amagana Dolo; Ogobara K Doumbo; Adrian J F Luty; Andre J A M van der Ven; Cornelus C Hermsen; Robert W Sauerwein
Memory-like IFN-γ response by NK cells following malaria infection reveals the crucial role of T cells in NK cell activation by P. falciparum.
European journal of immunology 2010;40(12):3472-7.
2010: Quirijn de Mast; Philip G de Groot; Waander L van Heerde; Meta Roestenberg; Jeroen F van Velzen; Bert Verbruggen; Mark Roest; Matthew McCall; An-Emmie Nieman; Josien Westendorp; Din Syafruddin; Rob Fijnheer; Edmee C van Dongen-Lases; Robert W Sauerwein; Andre J A M van der Ven
Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy.
British journal of haematology 2010;151(5):495-503.
2010: Matthew B B McCall; Robert W Sauerwein
Interferon-γ--central mediator of protective immune responses against the pre-erythrocytic and blood stage of malaria.
Journal of leukocyte biology 2010;88(6):1131-43.
2010: Aminatou Kone; Marga van de Vegte-Bolmer; Rianne Siebelink-Stoter; Geert-Jan van Gemert; Antoine Dara; Hamidou Niangaly; Adrian J F Luty; Ogobara K Doumbo; Robert W Sauerwein; Abdoulaye A Djimde
Sulfadoxine-pyrimethamine impairs Plasmodium falciparum gametocyte infectivity and Anopheles mosquito survival.
International journal for parasitology 2010;40(10):1221-8.
2010: Francesco Silvestrini; Edwin Lasonder; Anna Olivieri; Grazia Camarda; Ben van Schaijk; Massimo Sanchez; Sumera Younis Younis; Robert W Sauerwein; Pietro Alano
Protein export marks the early phase of gametocytogenesis of the human malaria parasite Plasmodium falciparum.
Molecular & cellular proteomics : MCP 2010;9(7):1437-48.
2010: Robert W Sauerwein; Else M Bijker; Thomas L Richie
Empowering malaria vaccination by drug administration.
Current opinion in immunology 2010;22(3):367-73.
2010: Matthew B B McCall; Bart Ferwerda; Joost Hopman; Ivo Ploemen; Boubacar Maiga; Modibo Daou; Amagana Dolo; Cornelus C Hermsen; Ogobara K Doumbo; George Bedu-Addo; Jos W van der Meer; Marita Troye-Blomberg; Andre J A M van der Ven; Ralf R Schumann; Robert W Sauerwein; Frank P Mockenhaupt; Mihai G Netea
Persistence of full-length caspase-12 and its relation to malaria in West and Central African populations.
European cytokine network 2010;21(2):77-83.
2010: Teun Bousema; Chris Drakeley; Samwel Gesase; Ramadhan Hashim; Stephen M Magesa; Frank Mosha; Silas Otieno; Ilona Carneiro; Jonathan Cox; Eliapendavyo Msuya; Immo Kleinschmidt; Caroline Maxwell; Brian Greenwood; Eleanor Riley; Robert W Sauerwein; Daniel Chandramohan; Roly D Gosling
Identification of hot spots of malaria transmission for targeted malaria control.
The Journal of infectious diseases 2010;201(11):1764-74.
2010: Seif A Shekalaghe; Roel ter Braak; Modibo Daou; Reginald Kavishe; Wouter van den Bijllaardt; Sven van den Bosch; Jan B Koenderink; Adrian J F Luty; Christopher J M Whitty; Chris Drakeley; Robert W Sauerwein; Teun Bousema
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Antimicrobial agents and chemotherapy 2010;54(5):1762-8.
2010: Melissa R van Dijk; Ben C L van Schaijk; Shahid M Khan; Maaike W van Dooren; Jai Ramesar; Szymon Kaczanowski; Geert-Jan van Gemert; Hans Kroeze; Hendrik G Stunnenberg; Wijnand Eling; Robert W Sauerwein; Andrew P Waters; Chris J Janse
Three members of the 6-cys protein family of Plasmodium play a role in gamete fertility.
PLoS pathogens 2010;6(4):e1000853.
2010: Ben C L van Schaijk; Martijn W Vos; Chris J Janse; Robert W Sauerwein; Shahid M Khan
Removal of heterologous sequences from Plasmodium falciparum mutants using FLPe-recombinase.
PloS one 2010;5(11):e15121.
2010: Teun Bousema; Will Roeffen; Hinta Meijerink; Harry Mwerinde; Steve Mwakalinga; Geert-Jan van Gemert; Marga van de Vegte-Bolmer; Frank Mosha; Geoffrey A T Targett; Eleanor M Riley; Robert W Sauerwein; Chris Drakeley
The dynamics of naturally acquired immune responses to Plasmodium falciparum sexual stage antigens Pfs230 & Pfs48/45 in a low endemic area in Tanzania.
PloS one 2010;5(11):e14114.
2010: André Lin Ouédraogo; Teun Bousema; Sake J de Vlas; Nadine Cuzin-Ouattara; Jan Peter Verhave; Chris Drakeley; Adrian J F Luty; Robert W Sauerwein
The plasticity of Plasmodium falciparum gametocytaemia in relation to age in Burkina Faso.
Malaria journal 2010;9():281.
2010: Christian W Wang; Steven B Mwakalinga; Colin J Sutherland; Samana Schwank; Sarah Sharp; Cornelus C Hermsen; Robert W Sauerwein; Thor G Theander; Thomas Lavstsen
Identification of a major rif transcript common to gametocytes and sporozoites of Plasmodium falciparum.
Malaria journal 2010;9():147.
2010: Teun Bousema; Lucy Okell; Seif Shekalaghe; Jamie T Griffin; Sabah Omar; Patrick Sawa; Colin Sutherland; Robert W Sauerwein; Azra C Ghani; Chris Drakeley
Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs.
Malaria journal 2010;9():136.
2010: Matthew B B McCall; Joost Hopman; Modibo Daou; Boubacar Maiga; Victor Dara; Ivo Ploemen; Krystelle Nganou-Makamdop; Amadou Niangaly; Youssouf Tolo; Charles Arama; J Teun Bousema; Jos W van der Meer; Andre J A M van der Ven; Marita Troye-Blomberg; Amagana Dolo; Ogobara K Doumbo; Robert W Sauerwein
Early interferon-gamma response against Plasmodium falciparum correlates with interethnic differences in susceptibility to parasitemia between sympatric Fulani and Dogon in Mali.
The Journal of infectious diseases 2010;201(1):142-52.
2009: Christian W Wang; Cornelus C Hermsen; Robert W Sauerwein; David E Arnot; Thor G Theander; Thomas Lavstsen
The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer.
Parasitology international 2009;58(4):478-80.
2009: Martijn Beurskens; Petra Mens; Henk D F H Schallig; Din Syafruddin; Puji Budi Setia Asih; Rob Hermsen; Robert W Sauerwein
Quantitative determination of Plasmodium vivax gametocytes by real-time quantitative nucleic acid sequence-based amplification in clinical samples.
The American journal of tropical medicine and hygiene 2009;81(2):366-9.
2009: Meta Roestenberg; Matthew McCall; Joost Hopman; Jorien Wiersma; Adrian J F Luty; Geert-Jan van Gemert; Marga van de Vegte-Bolmer; Ben van Schaijk; Karina Teelen; Theo Arens; Lopke Spaarman; Quirijn de Mast; Will Roeffen; Georges Snounou; Laurent Rénia; Andre J A M van der Ven; Cornelus C Hermsen; Robert W Sauerwein
Protection against a malaria challenge by sporozoite inoculation.
The New England journal of medicine 2009;361(5):468-77.
2009: Anna Olivieri; Grazia Camarda; Lucia Bertuccini; Marga van de Vegte-Bolmer; Adrian J F Luty; Robert W Sauerwein; Pietro Alano
The Plasmodium falciparum protein Pfg27 is dispensable for gametocyte and gamete production, but contributes to cell integrity during gametocytogenesis.
Molecular microbiology 2009;73(2):180-93.
2009: Adriana M Salcedo-Amaya; Marc A van Driel; Blaise T Alako; Morten B Trelle; Antonia M G van den Elzen; Adrian M Cohen; Eva M Janssen-Megens; Marga van de Vegte-Bolmer; Rebecca R Selzer; A Leonardo Iniguez; Roland D Green; Robert W Sauerwein; Ole N Jensen; Hendrik G Stunnenberg
Dynamic histone H3 epigenome marking during the intraerythrocytic cycle of Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(24):9655-60.
2009: Puji B S Asih; Rita M Dewi; Sekar Tuti; Mohamad Sadikin; Wajio Sumarto; Bonar Sinaga; Andre J A M van der Ven; Robert W Sauerwein; Din Syafruddin
Efficacy of artemisinin-based combination therapy for treatment of persons with uncomplicated Plasmodium falciparum malaria in West Sumba District, East Nusa Tenggara Province, Indonesia, and genotypic profiles of the parasite.
The American journal of tropical medicine and hygiene 2009;80(6):914-8.
2009: Quirijn de Mast; Edmee C van Dongen-Lases; Dorine W Swinkels; An-Emmie Nieman; Meta Roestenberg; Pierre Druilhe; Theo A Arens; Adrian J F Luty; Cornelus C Hermsen; Robert W Sauerwein; Andre J A M van der Ven
Mild increases in serum hepcidin and interleukin-6 concentrations impair iron incorporation in haemoglobin during an experimental human malaria infection.
British journal of haematology 2009;145(5):657-64.
2009: Franca C Hartgers; Benedicta Obeng; Yvonne C M Kruize; Annemiek Dijkhuis; Matthew McCall; Robert W Sauerwein; Adrian J F Luty; Daniel Boakye; Maria Yazdanbakhsh
Responses to malarial antigens are altered in helminth-infected children.
The Journal of infectious diseases 2009;199(10):1528-35.
2009: Robert W Sauerwein
Clinical malaria vaccine development.
Immunology letters 2009;122(2):115-7.
2009: Quirijn de Mast; Behzad Nadjm; Hugh Reyburn; Erwin H J M Kemna; Ben Amos; Coby M M Laarakkers; Simphorosa Silalye; Hans Verhoef; Robert W Sauerwein; Dorine W Swinkels; Andre J A M van der Ven
Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infection.
The Journal of infectious diseases 2009;199(2):253-62.
2009: André Lin Ouédraogo; Teun Bousema; Petra Schneider; Sake J de Vlas; Edith Ilboudo-Sanogo; Nadine Cuzin-Ouattara; Issa Nébié; Will Roeffen; Jan Peter Verhave; Adrian J F Luty; Robert W Sauerwein
Substantial contribution of submicroscopical Plasmodium falciparum gametocyte carriage to the infectious reservoir in an area of seasonal transmission.
PloS one 2009;4(12):e8410.
2009: An-Emmie Nieman; Quirijn de Mast; Meta Roestenberg; Jorien Wiersma; Gheorghe Pop; Anton Stalenhoef; Pierre Druilhe; Robert W Sauerwein; Andre J A M van der Ven
Cardiac complication after experimental human malaria infection: a case report.
Malaria journal 2009;8():277.
2009: Ivo Ploemen; Miguel Prudêncio; Bruno G Douradinha; Jai Ramesar; Jannik Fonager; Geert-Jan van Gemert; Adrian J F Luty; Cornelus C Hermsen; Robert W Sauerwein; Fernanda G Baptista; Maria M Mota; Andrew P Waters; Ivo Que; Clemens W G M Lowik; Shahid M Khan; Chris J Janse; Blandine M D Franke-Fayard
Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging.
PloS one 2009;4(11):e7881.
2009: David Courtin; Mayke Oesterholt; Harm Huismans; Kwadwo Asamoah Kusi; Jacqueline Milet; cyril badaut; Oumar Gaye; Will Roeffen; Edmond J Remarque; Robert W Sauerwein; André Garcia; Adrian J F Luty
The quantity and quality of African children's IgG responses to merozoite surface antigens reflect protection against Plasmodium falciparum malaria.
PloS one 2009;4(10):e7590.
2009: Puji B S Asih; William O Rogers; Agustina I Susanti; Agus Rahmat; Ismail E Rozi; Mariska A Kusumaningtyas; Rita M Dewi; Farah N Coutrier; Awalludin Sutamihardja; Andre J A M van der Ven; Robert W Sauerwein; Din Syafruddin
Seasonal distribution of anti-malarial drug resistance alleles on the island of Sumba, Indonesia.
Malaria journal 2009;8():222.
2009: Bart Ferwerda; Matthew B B McCall; Maaike C de Vries; Joost Hopman; Boubacar Maiga; Amagana Dolo; Ogobara K Doumbo; Modibo Daou; Dirk de Jong; Leo A B Joosten; Rudi A Tissingh; Frans A G Reubsaet; Robert W Sauerwein; Jos W M van der Meer; André J A M van der Ven; Mihai G Netea
Caspase-12 and the inflammatory response to Yersinia pestis.
PloS one 2009;4(9):e6870.
2009: Seif Shekalaghe; Michael Alifrangis; Charles Mwanziva; Anders Enevold; Steve Mwakalinga; Humphrey Mkali; Reginald Kavishe; Alphaxard Manjurano; Robert W Sauerwein; Chris Drakeley; Teun Bousema
Low density parasitaemia, red blood cell polymorphisms and Plasmodium falciparum specific immune responses in a low endemic area in northern Tanzania.
BMC infectious diseases 2009;9():69.
2009: Mayke J A M Oesterholt; Michael Alifrangis; Colin J Sutherland; Sabah A Omar; Patrick Sawa; Christina Howitt; Louis C Gouagna; Robert W Sauerwein; Teun Bousema
Submicroscopic gametocytes and the transmission of antifolate-resistant Plasmodium falciparum in Western Kenya.
PloS one 2009;4(2):e4364.
2008: Miguel Prudêncio; Cristina D Rodrigues; Michael Hannus; Cécilie Martin; Eliana Real; Lígia Antunes Gonçalves; Céline Carret; Robert Dorkin; Ingo Röhl; Kerstin Jahn-Hoffmann; Adrian J F Luty; Robert W Sauerwein; Christophe J Echeverri; Maria M Mota
Kinome-wide RNAi screen implicates at least 5 host hepatocyte kinases in Plasmodium sporozoite infection.
PLoS pathogens 2008;4(11):e1000201.
2008: Edwin Lasonder; Chris J Janse; Geert-Jan van Gemert; Gunnar R Mair; Adriaan M W Vermunt; Bruno Douradinha; Vera van Noort; Martijn A Huynen; Adrian J F Luty; Hans Kroeze; Shahid M Khan; Robert W Sauerwein; Andrew P Waters; Matthias Mann; Hendrik G Stunnenberg
Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity.
PLoS pathogens 2008;4(10):e1000195.
2008: Samir Yalaoui; Thierry Huby; Jean-François Franetich; Audrey Gego; Armelle Rametti; Martine Moreau; Xavier Collet; Anthony Siau; Geert-Jan van Gemert; Robert W Sauerwein; Adrian J F Luty; Jean-Christophe Vaillant; Laurent Hannoun; John Chapman; Dominique Mazier; Patrick Froissard
Scavenger receptor BI boosts hepatocyte permissiveness to Plasmodium infection.
Cell host & microbe 2008;4(3):283-92.
2008: Cristina D Rodrigues; Michael Hannus; Miguel Prudêncio; Cécilie Martin; Lígia Antunes Gonçalves; Sílvia Portugal; Sabrina Epiphanio; Akin Akinc; Philipp Hadwiger; Kerstin Jahn-Hofmann; Ingo Röhl; Geert-Jan van Gemert; Jean-François Franetich; Adrian J F Luty; Robert W Sauerwein; Dominique Mazier; Victor Koteliansky; Hans-Peter Vornlocher; Christophe J Echeverri; Maria M Mota
Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection.
Cell host & microbe 2008;4(3):271-82.
2008: David Cavanagh; Edmond J Remarque; Robert W Sauerwein; Cornelus C Hermsen; Adrian J F Luty
Influenza virosomes: a flu jab for malaria?
Trends in parasitology 2008;24(9):382-5.
2008: Nassira Mahmoudi; Ramon Garcia-Domenech; Jorge Galvez; Khemais Farhati; Jean-François Franetich; Robert W Sauerwein; Laurent Hannoun; Francis Derouin; Martin Danis; Dominique Mazier
New active drugs against liver stages of Plasmodium predicted by molecular topology.
Antimicrobial agents and chemotherapy 2008;52(4):1215-20.
2008: Nikolay S Outchkourov; Will Roeffen; Anita Kaan; Josephine Jansen; Adrian Luty; Danielle Schuiffel; Geert-Jan van Gemert; Marga van de Vegte-Bolmer; Robert W Sauerwein; Hendrik G Stunnenberg
Correctly folded Pfs48/45 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(11):4301-5.
2008: J Teun Bousema; Chris Drakeley; Petra Mens; Theo Arens; Rein Houben; Sabah A Omar; Louis C Gouagna; Henk Schallig; Robert W Sauerwein
Increased Plasmodium falciparum gametocyte production in mixed infections with P. malariae.
The American journal of tropical medicine and hygiene 2008;78(3):442-8.
2008: Q De Mast; F C G J Sweep; M McCall; Anneke Geurts-Moespot; Cornelus C Hermsen; T Calandra; Mihai G Netea; Robert W Sauerwein; Andre J A M van der Ven
A decrease of plasma macrophage migration inhibitory factor concentration is associated with lower numbers of circulating lymphocytes in experimental Plasmodium falciparum malaria.
Parasite immunology 2008;30(3):133-8.
2008: Bruno Douradinha; Maria M Mota; Adrian J F Luty; Robert W Sauerwein
Cross-species immunity in malaria vaccine development: two, three, or even four for the price of one?
Infection and immunity 2008;76(3):873-8.
2008: Charles Mwanziva; Seif Shekalaghe; Arnold Ndaro; Bianca Mengerink; Simon Megiroo; Frank Mosha; Robert W Sauerwein; Chris Drakeley; Roly Gosling; Teun Bousema
Overuse of artemisinin-combination therapy in Mto wa Mbu (river of mosquitoes), an area misinterpreted as high endemic for malaria.
Malaria journal 2008;7():232.
2008: Ben C L van Schaijk; Chris J Janse; Geert-Jan van Gemert; Melissa R van Dijk; Audrey Gego; Jean-Francois Franetich; Marga van de Vegte-Bolmer; Samir Yalaoui; Olivier Silvie; Stephen L Hoffman; Andrew P Waters; Dominique Mazier; Robert W Sauerwein; Shahid M Khan
Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes.
PloS one 2008;3(10):e3549.
2008: Margarida Cunha-Rodrigues; Sílvia Portugal; Miguel Prudêncio; Lígia Antunes Gonçalves; Cristina Casalou; Dominik Buger; Robert W Sauerwein; Werner Haas; Maria M Mota
Genistein-supplemented diet decreases malaria liver infection in mice and constitutes a potential prophylactic strategy.
PloS one 2008;3(7):e2732.
2008: André Lin Ouédraogo; Sake J de Vlas; Issa Nébié; Edith Ilboudo-Sanogo; J Teun Bousema; Aboubakar S Ouattara; Jan Peter Verhave; Nadine Cuzin-Ouattara; Robert W Sauerwein
Seasonal patterns of Plasmodium falciparum gametocyte prevalence and density in a rural population of Burkina Faso.
Acta tropica 2008;105(1):28-34.
2007: Bruno Douradinha; Melissa R van Dijk; Ricardo Ataide; Geert-Jan van Gemert; Joanne Thompson; Jean-François Franetich; Dominique Mazier; Adrian J F Luty; Robert W Sauerwein; Chris J Janse; Andrew P Waters; Maria M Mota
Genetically attenuated P36p-deficient Plasmodium berghei sporozoites confer long-lasting and partial cross-species protection.
International journal for parasitology 2007;37(13):1511-9.
2007: Bart Ferwerda; Matthew B B McCall; Santos Alonso; Evangelos J Giamarellos-Bourboulis; Maria Mouktaroudi; Neskuts Izagirre; Din Syafruddin; Gibson S Kibiki; Tudor Cristea; Anneke Hijmans; Lutz Hamann; Shoshana Israel; Gehad Elghazali; Marita Troye-Blomberg; Oliver Kumpf; Boubacar Maiga; Amagana Dolo; Ogobara K Doumbo; Cornelus C Hermsen; Anton F H Stalenhoef; Reinout van Crevel; Han G Brunner; Djin-Ye Oh; Ralf R Schumann; Concepcion de la Rúa; Robert W Sauerwein; Bart Jan Kullberg; Andre J A M van der Ven; Jos W M van der Meer; Mihai G Netea
TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(42):16645-50.
2007: Louis C Gouagna; Mike van der Kolk; Will Roeffen; Jan Peter Verhave; Wijnand Eling; Robert W Sauerwein; Christian Boudin
Role of heat-labile serum factor or host complement in the inhibition of Plasmodium falciparum sporogonic stages in Anopheles stephensi by gametocyte carriers' serological factors.
Parasitology 2007;134(Pt 10):1315-27.
2007: Quirijn de Mast; Evelyn Groot; Peter J Lenting; Philip G de Groot; Matthew McCall; Robert W Sauerwein; Rob Fijnheer; Andre J A M van der Ven
Thrombocytopenia and release of activated von Willebrand Factor during early Plasmodium falciparum malaria.
The Journal of infectious diseases 2007;196(4):622-8.
2007: Matthew B B McCall; Mihai G Netea; Cornelus C Hermsen; Trees Jansen; Liesbeth Jacobs; Douglas T Golenbock; Andre J A M van der Ven; Robert W Sauerwein
Plasmodium falciparum infection causes proinflammatory priming of human TLR responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):162-71.
2007: Meta Roestenberg; Matthew McCall; Tom Eirik Mollnes; Marcel van Deuren; Tom Sprong; Ina S Klasen; Cornelus C Hermsen; Robert W Sauerwein; Andre J A M van der Ven
Complement activation in experimental human malaria infection.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2007;101(7):643-9.
2007: Nikolay S Outchkourov; Adriaan Vermunt; Josephine Jansen; Anita M Kaan; Will Roeffen; Karina Teelen; Edwin Lasonder; Anneke Braks; Marga van de Vegte-Bolmer; Li Yan Qiu; Robert W Sauerwein; Hendrik G Stunnenberg
Epitope analysis of the malaria surface antigen pfs48/45 identifies a subdomain that elicits transmission blocking antibodies.
The Journal of biological chemistry 2007;282(23):17148-56.
2007: J Teun Bousema; Chris Drakeley; Japheth Kihonda; Jan C M Hendriks; N I J Akim; Will Roeffen; Robert W Sauerwein
A longitudinal study of immune responses to Plasmodium falciparum sexual stage antigens in Tanzanian adults.
Parasite immunology 2007;29(6):309-17.
2007: Shinji L Okitsu; Ursula Kienzl; Kerstin Moehle; Olivier Silvie; Elisabetta Peduzzi; Markus S Mueller; Robert W Sauerwein; Hugues Matile; Rinaldo Zurbriggen; Dominique Mazier; John A Robinson; Gerd Pluschke
Structure-activity-based design of a synthetic malaria peptide eliciting sporozoite inhibitory antibodies in a virosomal formulation.
Chemistry & biology 2007;14(5):577-87.
2007: Robert W Sauerwein
Malaria transmission-blocking vaccines: the bonus of effective malaria control.
Microbes and infection / Institut Pasteur 2007;9(6):792-5.
2007: Cornelus C Hermsen; Danielle F Verhage; Denise S C Telgt; Karina Teelen; J Teun Bousema; Meta Roestenberg; Ahmed Bolad; Klavs Berzins; Giampietro Corradin; Odile Leroy; Michael Theisen; Robert W Sauerwein
Glutamate-rich protein (GLURP) induces antibodies that inhibit in vitro growth of Plasmodium falciparum in a phase 1 malaria vaccine trial.
Vaccine 2007;25(15):2930-40.
2007: Seif A Shekalaghe; J Teun Bousema; Karaine K Kunei; Paminus Lushino; Alutu Masokoto; Liselotte R Wolters; Steve Mwakalinga; Frank Mosha; Robert W Sauerwein; Chris Drakeley
Submicroscopic Plasmodium falciparum gametocyte carriage is common in an area of low and seasonal transmission in Tanzania.
Tropical medicine & international health : TM & IH 2007;12(4):547-53.
2007: André Lin Ouédraogo; Petra Schneider; Marcel de Kruijf; Issa Nébié; Jan Peter Verhave; Nadine Cuzin-Ouattara; Robert W Sauerwein
Age-dependent distribution of Plasmodium falciparum gametocytes quantified by Pfs25 real-time QT-NASBA in a cross-sectional study in Burkina Faso.
The American journal of tropical medicine and hygiene 2007;76(4):626-30.
2007: Petra Schneider; J Teun Bousema; Louis C Gouagna; Silas Otieno; Marga van de Vegte-Bolmer; Sabah A Omar; Robert W Sauerwein
Submicroscopic Plasmodium falciparum gametocyte densities frequently result in mosquito infection.
The American journal of tropical medicine and hygiene 2007;76(3):470-4.
2007: Saliha Eksi; Beata Czesny; Geert-Jan van Gemert; Robert W Sauerwein; Wijnand Eling; Kim C Williamson
Inhibition of Plasmodium falciparum oocyst production by membrane-permeant cysteine protease inhibitor E64d.
Antimicrobial agents and chemotherapy 2007;51(3):1064-70.
2007: Shinji L Okitsu; Olivier Silvie; Nicole Westerfeld; Marija Curcic; Andreas Kammer; Markus S Mueller; Robert W Sauerwein; John A Robinson; Blaise Genton; Dominique Mazier; Rinaldo Zurbriggen; Gerd Pluschke
A virosomal malaria peptide vaccine elicits a long-lasting sporozoite-inhibitory antibody response in a phase 1a clinical trial.
PloS one 2007;2(12):e1278.
2007: Seif Shekalaghe; Chris Drakeley; Roly Gosling; Arnold Ndaro; Monique van Meegeren; Anders Enevold; Michael Alifrangis; Frank Mosha; Robert W Sauerwein; Teun Bousema
Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate.
PloS one 2007;2(10):e1023.
2006: Maëlle Carraz; Akino Jossang; Jean-François Franetich; Anthony Siau; Liliane Ciceron; Laurent Hannoun; Robert W Sauerwein; François Frappier; Philippe Rasoanaivo; Georges Snounou; Dominique Mazier
A plant-derived morphinan as a novel lead compound active against malaria liver stages.
PLoS medicine 2006;3(12):e513.
2006: Matthew B B McCall; Andy J Beynon; Emmanuel A M Mylanus; Andre J A M van der Ven; Robert W Sauerwein
No hearing loss associated with the use of artemether-lumefantrine to treat experimental human malaria.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2006;100(12):1098-104.
2006: Reginald A Kavishe; Jan B Koenderink; Matthew B B McCall; Wilbert H M Peters; Bert Mulder; Cornelus C Hermsen; Robert W Sauerwein; Frans G M Russel; Andre J A M van der Ven
Short report: Severe Plasmodium falciparum malaria in Cameroon: associated with the glutathione S-transferase M1 null genotype.
The American journal of tropical medicine and hygiene 2006;75(5):827-9.
2006: Ben C L van Schaijk; Melissa R van Dijk; Marga van de Vegte-Bolmer; Geert-Jan van Gemert; Maaike W van Dooren; Saliha Eksi; Will Roeffen; Chris J Janse; Andrew P Waters; Robert W Sauerwein
Pfs47, paralog of the male fertility factor Pfs48/45, is a female specific surface protein in Plasmodium falciparum.
Molecular and biochemical parasitology 2006;149(2):216-22.
2006: Chris Drakeley; Colin Sutherland; J Teun Bousema; Robert W Sauerwein; Geoffrey A T Targett
The epidemiology of Plasmodium falciparum gametocytes: weapons of mass dispersion.
Trends in parasitology 2006;22(9):424-30.
2006: Mike van der Kolk; Sake J de Vlas; Robert W Sauerwein
Reduction and enhancement of Plasmodium falciparum transmission by endemic human sera.
International journal for parasitology 2006;36(10-11):1091-5.
2006: Saliha Eksi; Beata Czesny; Geert-Jan van Gemert; Robert W Sauerwein; Wijnand Eling; Kim C Williamson
Malaria transmission-blocking antigen, Pfs230, mediates human red blood cell binding to exflagellating male parasites and oocyst production.
Molecular microbiology 2006;61(4):991-8.
2006: Olivier Silvie; Céline Greco; Jean-François Franetich; Anne Dubart Kupperschmitt; Laurent Hannoun; Geert-Jan van Gemert; Robert W Sauerwein; Shoshana Levy; Claude Boucheix; Eric Rubinstein; Dominique Mazier
Expression of human CD81 differently affects host cell susceptibility to malaria sporozoites depending on the Plasmodium species.
Cellular microbiology 2006;8(7):1134-46.
2006: Olivier Silvie; Stéphanie Charrin; Martine Billard; Jean-François Franetich; Krista L Clark; Geert-Jan van Gemert; Robert W Sauerwein; François Dautry; Claude Boucheix; Dominique Mazier; Eric Rubinstein
Cholesterol contributes to the organization of tetraspanin-enriched microdomains and to CD81-dependent infection by malaria sporozoites.
Journal of cell science 2006;119(Pt 10):1992-2002.
2006: Din Syafruddin; Puji B S Asih; Farah N Coutrier; Leily Trianty; Rintis Noviyanti; Yaveth Luase; Wajiyo Sumarto; Marten Caley; Andre J A M van der Ven; Robert W Sauerwein
Malaria in Wanokaka and Loli sub-districts, West Sumba District, East Nusa Tenggara Province, Indonesia.
The American journal of tropical medicine and hygiene 2006;74(5):733-7.
2006: Chris Drakeley; J Teun Bousema; N I J Akim; Karina Teelen; Will Roeffen; AH Lensen; M Bolmer; Wijnand Eling; Robert W Sauerwein
Transmission-reducing immunity is inversely related to age in Plasmodium falciparum gametocyte carriers.
Parasite immunology 2006;28(5):185-90.
2006: J Teun Bousema; Petra Schneider; Louis C Gouagna; Chris Drakeley; Alma Tostmann; Rein Houben; John I Githure; Rosalynn Ord; Colin J Sutherland; Sabah A Omar; Robert W Sauerwein
Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparum.
The Journal of infectious diseases 2006;193(8):1151-9.
2006: Audrey Gego; Olivier Silvie; Jean-François Franetich; Khemais Farhati; Laurent Hannoun; Adrian J F Luty; Robert W Sauerwein; Claude Boucheix; Eric Rubinstein; Dominique Mazier
New approach for high-throughput screening of drug activity on Plasmodium liver stages.
Antimicrobial agents and chemotherapy 2006;50(4):1586-9.
2006: Serban Morosan; Stéphanie Hez-Deroubaix; Françoise Lunel; Laurent Renia; Carlo Giannini; Nico van Rooijen; Serena Battaglia; Catherine Blanc; Wijnand Eling; Robert W Sauerwein; Laurent Hannoun; Jacques Belghiti; Christian Brechot; Dina Kremsdorf; Pierre Druilhe
Liver-stage development of Plasmodium falciparum, in a humanized mouse model.
The Journal of infectious diseases 2006;193(7):996-1004.
2006: Petra Schneider; Teun Bousema; Sabah Omar; Louis C Gouagna; Patrick Sawa; Henk D F H Schallig; Robert W Sauerwein
(Sub)microscopic Plasmodium falciparum gametocytaemia in Kenyan children after treatment with sulphadoxine-pyrimethamine monotherapy or in combination with artesunate.
International journal for parasitology 2006;36(4):403-8.
2006: J Teun Bousema; Will Roeffen; Mike van der Kolk; Sake J de Vlas; Marga van de Vegte-Bolmer; Michael J Bangs; Karina Teelen; Liliana Kurniawan; Jason D Maguire; J Kevin Baird; Robert W Sauerwein
Rapid onset of transmission-reducing antibodies in javanese migrants exposed to malaria in papua, indonesia.
The American journal of tropical medicine and hygiene 2006;74(3):425-31.
2006: J Teun Bousema; Chris Drakeley; Robert W Sauerwein
Sexual-stage antibody responses to P. falciparum in endemic populations.
Current molecular medicine 2006;6(2):223-9.
2006: Chris J Janse; Blandine Franke-Fayard; Gunnar R Mair; Jai Ramesar; Corinna Thiel; Sabine Engelmann; Kai Matuschewski; Geert-Jan van Gemert; Robert W Sauerwein; Andrew P Waters
High efficiency transfection of Plasmodium berghei facilitates novel selection procedures.
Molecular and biochemical parasitology 2006;145(1):60-70.
2005: J Damoiseaux; A van der Ven; Rob Hermsen; Denise S C Telgt; Meta Roestenberg; J W Cohen Tervaert; Robert W Sauerwein
Experimental infection with Plasmodium falciparum does not result in the induction of anticardiolipin antibodies in healthy volunteers.
Annals of the rheumatic diseases 2005;64(12):1804-5.
2005: Frank P Mockenhaupt; J Teun Bousema; Teunis A Eggelte; Jonas Schreiber; Stephan Ehrhardt; Nasstasja Wassilew; Rowland N Otchwemah; Robert W Sauerwein; Ulrich Bienzle
Plasmodium falciparum dhfr but not dhps mutations associated with sulphadoxine-pyrimethamine treatment failure and gametocyte carriage in northern Ghana.
Tropical medicine & international health : TM & IH 2005;10(9):901-8.
2005: Melissa R van Dijk; Bruno Douradinha; Blandine Franke-Fayard; Volker T Heussler; Maaike W van Dooren; Ben van Schaijk; Geert-Jan van Gemert; Robert W Sauerwein; Maria M Mota; Andrew P Waters; Chris J Janse
Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(34):12194-9.
2005: Frank P Mockenhaupt; Stephan Ehrhardt; Stephen Y Dzisi; J Teun Bousema; Nasstasja Wassilew; Jonas Schreiber; Sylvester D Anemana; Jakob P Cramer; Rowland N Otchwemah; Robert W Sauerwein; Teunis A Eggelte; Ulrich Bienzle
A randomized, placebo-controlled, double-blind trial on sulfadoxine-pyrimethamine alone or combined with artesunate or amodiaquine in uncomplicated malaria.
Tropical medicine & international health : TM & IH 2005;10(6):512-20.
2005: Patrícia Leirião; Sónia S Albuquerque; Simona Corso; Geert-Jan van Gemert; Robert W Sauerwein; Ana Rodriguez; silvia giordano; Maria M Mota
HGF/MET signalling protects Plasmodium-infected host cells from apoptosis.
Cellular microbiology 2005;7(4):603-9.
2005: Denise S C Telgt; Andre J A M van der Ven; Barbara Schimmer; Han A Droogleever-Fortuyn; Robert W Sauerwein
Serious psychiatric symptoms after chloroquine treatment following experimental malaria infection.
The Annals of pharmacotherapy 2005;39(3):551-4.
2005: Danielle F Verhage; Denise S C Telgt; J Teun Bousema; Cornelus C Hermsen; Geert-Jan van Gemert; J W M Van Der Meer; Robert W Sauerwein
Clinical outcome of experimental human malaria induced by Plasmodium falciparum-infected mosquitoes.
The Netherlands journal of medicine 2005;63(2):52-8.
2005: Frank P Mockenhaupt; J Teun Bousema; Teunis A Eggelte; Stephan Ehrhardt; Rowland N Otchwemah; Robert W Sauerwein; Ulrich Bienzle
Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana.
Malaria journal 2005;4():42.
2005: Thomas Lavstsen; Pamela Magistrado; Cornelus C Hermsen; Ali Salanti; Anja T R Jensen; Robert W Sauerwein; Lars Hviid; Thor G Theander; Trine Staalsoe
Expression of Plasmodium falciparum erythrocyte membrane protein 1 in experimentally infected humans.
Malaria journal 2005;4(1):21.
2005: Mike van der Kolk; Sake J de Vlas; Allan Saul; Marga van de Vegte-Bolmer; Wijnand Eling; Robert W Sauerwein; W Sauerwein
Evaluation of the standard membrane feeding assay (SMFA) for the determination of malaria transmission-reducing activity using empirical data.
Parasitology 2005;130(Pt 1):13-22.
2005: Petra Schneider; Liselotte Wolters; Gerard Schoone; Henk D F H Schallig; Peter Sillekens; Rob Hermsen; Robert W Sauerwein
Real-time nucleic acid sequence-based amplification is more convenient than real-time PCR for quantification of Plasmodium falciparum.
Journal of clinical microbiology 2005;43(1):402-5.
2004: Louis C Gouagna; Sarah Bonnet; R Gounoue; Jan Peter Verhave; Wijnand Eling; Robert W Sauerwein; Christian Boudin
Stage-specific effects of host plasma factors on the early sporogony of autologous Plasmodium falciparum isolates within Anopheles gambiae.
Tropical medicine & international health : TM & IH 2004;9(9):937-48.
2004: Petra Schneider; Gerard Schoone; Henk D F H Schallig; Danielle F Verhage; Denise S C Telgt; Wijnand Eling; Robert W Sauerwein
Quantification of Plasmodium falciparum gametocytes in differential stages of development by quantitative nucleic acid sequence-based amplification.
Molecular and biochemical parasitology 2004;137(1):35-41.
2004: Cornelus C Hermsen; Sake J de Vlas; Geert-Jan van Gemert; Denise S C Telgt; Danielle F Verhage; Robert W Sauerwein
Testing vaccines in human experimental malaria: statistical analysis of parasitemia measured by a quantitative real-time polymerase chain reaction.
The American journal of tropical medicine and hygiene 2004;71(2):196-201.
2004: J Teun Bousema; Louis C Gouagna; Chris Drakeley; Annemiek M Meutstege; Bernard A Okech; Ikupa N J Akim; John C Beier; John I Githure; Robert W Sauerwein
Plasmodium falciparum gametocyte carriage in asymptomatic children in western Kenya.
Malaria journal 2004;3():18.
2004: Anja T R Jensen; Pamela Magistrado; Sarah Sharp; Louise Joergensen; Thomas Lavstsen; Antonella Chiucchiuini; Ali Salanti; Lasse S Vestergaard; John P A Lusingu; Rob Hermsen; Robert W Sauerwein; Jesper Christensen; Morten A Nielsen; Lars Hviid; Colin Sutherland; Trine Staalsoe; Thor G Theander
Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes.
The Journal of experimental medicine 2004;199(9):1179-90.
2004: Chris Drakeley; Wijnand Eling; Karina Teelen; J Teun Bousema; Robert W Sauerwein; Brian M Greenwood; Geoffrey A T Targett
Parasite infectivity and immunity to Plasmodium falciparum gametocytes in Gambian children.
Parasite immunology 2004;26(4):159-65.
2004: Myriam Bodescot; Olivier Silvie; Anthony Siau; Philippe Refour; Paco Pino; Jean-François Franetich; Laurent Hannoun; Robert W Sauerwein; Dominique Mazier
Transcription status of vaccine candidate genes of Plasmodium falciparum during the hepatic phase of its life cycle.
Parasitology research 2004;92(6):449-52.
2004: Olivier Silvie; Jean-François Franetich; Stéphanie Charrin; Markus S Mueller; Anthony Siau; Myriam Bodescot; Eric Rubinstein; Laurent Hannoun; Yupin Charoenvit; Clemens H M Kocken; Alan Thomas; Geert-Jan van Gemert; Robert W Sauerwein; Michael J Blackman; Robin F Anders; Gerd Pluschke; Dominique Mazier
A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites.
The Journal of biological chemistry 2004;279(10):9490-6.
2003: Nassira Mahmoudi; Liliane Ciceron; Jean-François Franetich; Khemais Farhati; Olivier Silvie; Wijnand Eling; Robert W Sauerwein; Martin Danis; Dominique Mazier; Francis Derouin
In vitro activities of 25 quinolones and fluoroquinolones against liver and blood stage Plasmodium spp.
Antimicrobial agents and chemotherapy 2003;47(8):2636-9.
2003: Mike van der Kolk; Anne Tebo; Hermann Nimpaye; Delphine Ngo Ndombol; Robert W Sauerwein; Wijnand Eling
Transmission of Plasmodium falciparum in urban Yaoundé, Cameroon, is seasonal and age-dependent.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2003;97(4):375-9.
2003: Cornelus C Hermsen; Y Konijnenberg; L Mulder; C Loé; Marcel van Deuren; J W M Van Der Meer; G J van Mierlo; Wijnand Eling; C Erik Hack; Robert W Sauerwein
Circulating concentrations of soluble granzyme A and B increase during natural and experimental Plasmodium falciparum infections.
Clinical and experimental immunology 2003;132(3):467-72.
2003: J Teun Bousema; Louis C Gouagna; A M Meutstege; B E Okech; N I J Akim; John I Githure; John C Beier; Robert W Sauerwein
Treatment failure of pyrimethamine-sulphadoxine and induction of Plasmodium falciparum gametocytaemia in children in western Kenya.
Tropical medicine & international health : TM & IH 2003;8(5):427-30.
2002: Edwin Lasonder; Yasushi Ishihama; Jens S Andersen; Adriaan M W Vermunt; Arnab Pain; Robert W Sauerwein; Wijnand Eling; Neil Hall; Andrew P Waters; Hendrik G Stunnenberg; Matthias Mann
Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry.
Nature 2002;419(6906):537-42.
2002: N I J Akim; Honorathy Urassa; Chris Drakeley; Robert W Sauerwein; Andrew Y Kitua
Immunity to the sexual stages of Plasmodium falciparum in mothers, neonates and infants subject to intense and perennial malarial transmission.
Annals of tropical medicine and parasitology 2002;96(7):735-7.
2001: Cornelus C Hermsen; Denise S C Telgt; EH Linders; L A van de Locht; Wijnand Eling; E J B M Mensink; Robert W Sauerwein
Detection of Plasmodium falciparum malaria parasites in vivo by real-time quantitative PCR.
Molecular and biochemical parasitology 2001;118(2):247-51.
2001: Will Roeffen; Jos M H Raats; Karina Teelen; René M A Hoet; Wijnand Eling; Walther J van Venrooij; Robert W Sauerwein
Recombinant human antibodies specific for the Pfs48/45 protein of the malaria parasite Plasmodium falciparum.
The Journal of biological chemistry 2001;276(23):19807-11.
2001: Kordai Mp Sowa; David Cavanagh; Alison M Creasey; Jos M H Raats; J McBride; Robert W Sauerwein; Will Roeffen; David E Arnot
Isolation of a monoclonal antibody from a malaria patient-derived phage display library recognising the Block 2 region of Plasmodium falciparum merozoite surface protein-1.
Molecular and biochemical parasitology 2001;112(1):143-7.
2001: Melissa R van Dijk; Chris J Janse; J Thompson; Andrew P Waters; Joanna A M Braks; H J Dodemont; Hendrik G Stunnenberg; Geert-Jan van Gemert; Robert W Sauerwein; Wijnand Eling
A central role for P48/45 in malaria parasite male gamete fertility.
Cell 2001;104(1):153-64.
2001: Will Roeffen; Karina Teelen; J van As; M vd Vegte-Bolmer; Wijnand Eling; Robert W Sauerwein
Plasmodium falciparum: production and characterization of rat monoclonal antibodies specific for the sexual-stage Pfs48/45 antigen.
Experimental parasitology 2001;97(1):45-9.
2000: N I J Akim; Chris Drakeley; T Kingo; B Simon; K Senkoro; Robert W Sauerwein
Dynamics of P. falciparum gametocytemia in symptomatic patients in an area of intense perennial transmission in Tanzania.
The American journal of tropical medicine and hygiene 2000;63(3-4):199-203.
2000: Chris Drakeley; N I J Akim; Robert W Sauerwein; B M Greenwood; Geoffrey A T Targett
Estimates of the infectious reservoir of Plasmodium falciparum malaria in The Gambia and in Tanzania.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2000;94(5):472-6.
1999: B Mulder; T Lensen; Timoléon Tchuinkam; Will Roeffen; Jan Peter Verhave; Christian Boudin; Robert W Sauerwein
Plasmodium falciparum: membrane feeding assays and competition ELISAs for the measurement of transmission reduction in sera from Cameroon.
Experimental parasitology 1999;92(1):81-6.
1999: AH Lensen; A Bril; M van de Vegte; Geert-Jan van Gemert; Wijnand Eling; Robert W Sauerwein
Plasmodium falciparum: infectivity of cultured, synchronized gametocytes to mosquitoes.
Experimental parasitology 1999;91(1):101-3.
1998: Cornelus C Hermsen; E Mommers; TJ van de Wiel; Robert W Sauerwein; Wijnand Eling
Convulsions due to increased permeability of the blood-brain barrier in experimental cerebral malaria can be prevented by splenectomy or anti-T cell treatment.
The Journal of infectious diseases 1998;178(4):1225-7.
1998: RL Milek; Will Roeffen; Clemens H M Kocken; Josephine Jansen; Anita M Kaan; Wijnand Eling; Robert W Sauerwein; RN Konings
Immunological properties of recombinant proteins of the transmission blocking vaccine candidate, Pfs48/45, of the human malaria parasite Plasmodium falciparum produced in Escherichia coli.
Parasite immunology 1998;20(8):377-85.
1998: B Mulder; W van der Ligt; Robert W Sauerwein; Jan Peter Verhave
Detection of Plasmodium falciparum gametocytes with the OBC test and Giemsa-stained thick blood films for malaria transmission studies in Cameroon.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1998;92(4):395-6.
1998: Chris Drakeley; L Mulder; Timoléon Tchuinkam; S Gupta; Robert W Sauerwein; Geoffrey A T Targett
Transmission-blocking effects of sera from malaria-exposed individuals on Plasmodium falciparum isolates from gametocyte carriers.
Parasitology 1998;116 ( Pt 5)():417-23.
1998: Marcel van Deuren; Mihai G Netea; Anneke Hijmans; P N Demacker; Chris Neeleman; Robert W Sauerwein; Albert K M Bartelink; Jos W M van der Meer
Posttranscriptional down-regulation of tumor necrosis factor-alpha and interleukin-1beta production in acute meningococcal infections.
The Journal of infectious diseases 1998;177(5):1401-5.
1998: AH Lensen; L Mulder; Timoléon Tchuinkam; L Willemsen; Wijnand Eling; Robert W Sauerwein
Mechanisms that reduce transmission of Plasmodium falciparum malaria in semiimmune and nonimmune persons.
The Journal of infectious diseases 1998;177(5):1358-63.
1998: K Brinkman; S Debast; Robert W Sauerwein; F Ooyman; J Hiel; J Raemaekers
Toxoplasma retinitis/encephalitis 9 months after allogeneic bone marrow transplantation.
Bone marrow transplantation 1998;21(6):635-6.
1998: A L Beetsma; TJ van de Wiel; Robert W Sauerwein; Wijnand Eling
Plasmodium berghei ANKA: purification of large numbers of infectious gametocytes.
Experimental parasitology 1998;88(1):69-72.
1997: Cornelus C Hermsen; J V Crommert; H Fredix; Robert W Sauerwein; Wijnand Eling
Circulating tumour necrosis factor alpha is not involved in the development of cerebral malaria in Plasmodium berghei-infected C57Bl mice.
Parasite immunology 1997;19(12):571-7.
1997: AH Lensen; M Bolmer-Van de Vegte; Geert-Jan van Gemert; Wijnand Eling; Robert W Sauerwein
Leukocytes in a Plasmodium falciparum-infected blood meal reduce transmission of malaria to Anopheles mosquitoes.
Infection and immunity 1997;65(9):3834-7.
1997: Cornelus C Hermsen; TJ van de Wiel; E Mommers; Robert W Sauerwein; Wijnand Eling
Depletion of CD4+ or CD8+ T-cells prevents Plasmodium berghei induced cerebral malaria in end-stage disease.
Parasitology 1997;114 ( Pt 1)():7-12.
1996: R M Perenboom; P Beckers; Jos W M van der Meer; A C Van Schijndel; Wim J G Oyen; Frans H M Corstens; Robert W Sauerwein
Pro-inflammatory cytokines in lung and blood during steroid-induced Pneumocystis carinii pneumonia in rats.
Journal of leukocyte biology 1996;60(6):710-5.
1996: Evelien Dekker; Johannes A Romijn; Catherine Waruiru; Mariëtte T Ackermans; Gerrit Jan Weverling; Robert W Sauerwein; Erik Endert; Norbert Peshu; Kevin Marsh; Hans P Sauerwein
The relationship between glucose production and plasma glucose concentration in children with falciparum malaria.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1996;90(6):654-7.
1996: J T Frieling; Marcel van Deuren; J Wijdenes; R van Dalen; Albert K M Bartelink; Cees J Van Der Linden; Robert W Sauerwein
Interleukin-6 and its soluble receptor during acute meningococcal infections: effect of plasma or whole blood exchange.
Critical care medicine 1996;24(11):1801-5.
1996: B Mulder; Will Roeffen; Robert W Sauerwein; Timoléon Tchuinkam; Christian Boudin; Jan Peter Verhave
Anti-Pfs25 monoclonal antibody 32F81 blocks transmission from Plasmodium falciparum gametocyte carriers in Cameroon.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1996;90(2):195.
1996: Will Roeffen; B Mulder; K Teelen; M Bolmer; Wijnand Eling; Geoffrey A T Targett; P J Beckers; Robert W Sauerwein
Association between anti-Pfs48/45 reactivity and P. falciparum transmission-blocking activity in sera from Cameroon.
Parasite immunology 1996;18(2):103-9.
1996: R M Perenboom; A C van Schijndel; P Beckers; Robert W Sauerwein; H W Van Hamersvelt; J Festen; H Gallati; Jos W M van der Meer
Cytokine profiles in bronchoalveolar lavage fluid and blood in HIV-seronegative patients with Pneumocystis carinii pneumonia.
European journal of clinical investigation 1996;26(2):159-66.
1996: P J Beckers; G J Derks; T Gool; F J Rietveld; Robert W Sauerwein
Encephalocytozoon intestinalis-specific monoclonal antibodies for laboratory diagnosis of microsporidiosis.
Journal of clinical microbiology 1996;34(2):282-5.
1996: AH Lensen; J van Druten; M Bolmer; Geert-Jan van Gemert; Wijnand Eling; Robert W Sauerwein
Measurement by membrane feeding of reduction in Plasmodium falciparum transmission induced by endemic sera.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1996;90(1):20-2.
1995: S G Vreden; M F Van den Broek; M C Oettinger; W Boers; N Van-Rooijen; J H Meuwissen; Robert W Sauerwein
Susceptibility to Plasmodium berghei infection in rats is modulated by the acute phase response.
Parasite immunology 1995;17(9):445-50.
1995: S G Vreden; W L Blok; Robert W Sauerwein; M C Oettinger; Jan Peter Verhave; J E Meuwissen; J W Van der Meer; M F Van den Broek
Inhibition of Plasmodium berghei liver schizont development and reduction of cytokine production capacity in rats by dietary fish oil supplementation.
The American journal of tropical medicine and hygiene 1995;53(2):206-10.
1995: Marcel van Deuren; Johanna van der Ven-Jongekrijg; Albert K M Bartelink; R van Dalen; Robert W Sauerwein; Jos W M van der Meer
Correlation between proinflammatory cytokines and antiinflammatory mediators and the severity of disease in meningococcal infections.
The Journal of infectious diseases 1995;172(2):433-9.
1995: Will Roeffen; F Geeraedts; Wijnand Eling; P Beckers; Benjamin Wizel; Nirbhay Kumar; T Lensen; Robert W Sauerwein
Transmission blockade of Plasmodium falciparum malaria by anti-Pfs230-specific antibodies is isotype dependent.
Infection and immunity 1995;63(2):467-71.
1995: J T Frieling; Marcel van Deuren; J Wijdenes; Jos W M van der Meer; C Clement; Cees J Van Der Linden; Robert W Sauerwein
Circulating interleukin-6 receptor in patients with sepsis syndrome.
The Journal of infectious diseases 1995;171(2):469-72.
1995: Will Roeffen; P J Beckers; K Teelen; T Lensen; Robert W Sauerwein; J H Meuwissen; Wijnand Eling
Plasmodium falciparum: a comparison of the activity of Pfs230-specific antibodies in an assay of transmission-blocking immunity and specific competition ELISAs.
Experimental parasitology 1995;80(1):15-26.
1995: Will Roeffen; T Lensen; B Mulder; K Teelen; Robert W Sauerwein; J Van Druten; Wijnand Eling; J H Meuwissen; P J Beckers
A comparison of transmission-blocking activity with reactivity in a Plasmodium falciparum 48/45-kD molecule-specific competition enzyme-linked immunosorbent assay.
The American journal of tropical medicine and hygiene 1995;52(1):60-5.
1994: J T Frieling; Robert W Sauerwein; J Wijdenes; Thijs Hendriks; Cees J Van Der Linden
Soluble interleukin 6 receptor in biological fluids from human origin.
Cytokine 1994;6(4):376-81.
1994: M Keuter; E Dharmana; M H Gasem; J van der Ven-Jongekrijg; R Djokomoeljanto; W M Dolmans; Pierre N M Demacker; Robert W Sauerwein; H Gallati; Jos W M van der Meer
Patterns of proinflammatory cytokines and inhibitors during typhoid fever.
The Journal of infectious diseases 1994;169(6):1306-11.
1994: Marcel van Deuren; Johanna van der Ven-Jongekrijg; Pierre N M Demacker; Albert K M Bartelink; R van Dalen; Robert W Sauerwein; H Gallati; J L Vannice; Jos W M van der Meer
Differential expression of proinflammatory cytokines and their inhibitors during the course of meningococcal infections.
The Journal of infectious diseases 1994;169(1):157-61.
1994: Will Roeffen; T Lensen; B Mulder; K Teelen; Robert W Sauerwein; Wijnand Eling; J H Meuwissen; P Beckers
Transmission blocking immunity as observed in a feeder system and serological reactivity to Pfs 48/45 and Pfs230 in field sera.
Memórias do Instituto Oswaldo Cruz 1994;89 Suppl 2():13-5.
1993: R M Roumen; Thijs Hendriks; Johanna van der Ven-Jongekrijg; G A Nieuwenhuijzen; Robert W Sauerwein; Jos W M van der Meer; R Jan A Goris
Cytokine patterns in patients after major vascular surgery, hemorrhagic shock, and severe blunt trauma. Relation with subsequent adult respiratory distress syndrome and multiple organ failure.
Annals of surgery 1993;218(6):769-76.
1993: Will Roeffen; P J Beckers; K Teelen; Jan Peter Verhave; Wijnand Eling; Robert W Sauerwein
Comparison of serological tests and bio-assay for malaria transmission blocking capacity in field sera.
Parassitologia 1993;35 Suppl():95-7.
1993: S G Vreden; Robert W Sauerwein; Jan Peter Verhave; N Van Rooijen; J H Meuwissen; M F Van Den Broek
Kupffer cell elimination enhances development of liver schizonts of Plasmodium berghei in rats.
Infection and immunity 1993;61(5):1936-9.
1993: J Peter Donnelly; Petra Muus; Alphons Horrevorts; Robert W Sauerwein; B E De Pauw
Failure of clindamycin to influence the course of severe oromucositis associated with streptococcal bacteraemia in allogeneic bone marrow transplant recipients.
Scandinavian journal of infectious diseases 1993;25(1):43-50.
1992: Jacques Meis; Robert W Sauerwein; I C Gyssens; Alphons Horrevorts; A van Kampen
Kingella kingae intervertebral diskitis in an adult.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1992;15(3):530-2.
1992: Marcel van Deuren; F W Santman; R van Dalen; Robert W Sauerwein; Lambert Span; Jos W M van der Meer
Plasma and whole blood exchange in meningococcal sepsis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1992;15(3):424-30.
1992: S G Vreden; M F van den Broek; M C Oettinger; Jan Peter Verhave; J H Meuwissen; Robert W Sauerwein
Cytokines inhibit the development of liver schizonts of the malaria parasite Plasmodium berghei in vivo.
European journal of immunology 1992;22(9):2271-5.
1992: A van Amerongen; P J Beckers; H H Plasman; Wim M M Schaaper; Robert W Sauerwein; J H Meuwissen; Rob H Meloen
Peptides reactive with a transmission-blocking monoclonal antibody against Plasmodium falciparum Pfs25: 2000-fold affinity increase by PEPSCAN-based amino acid substitutions.
Peptide research 1992;5(5):269-74.
1992: J Peter Donnelly; Alphons Horrevorts; Robert W Sauerwein; B E De Pauw
High-dose meropenem in meningitis due to Pseudomonas aeruginosa.
Lancet 1992;339(8801):1117.
1992: Robert W Sauerwein; J W Lammers; Alphons Horrevorts
Ceftazidime monotherapy for pulmonary melioidosis in a traveler returning from Thailand.
Chest 1992;101(2):555-7.
1991: S G Vreden; Jan Peter Verhave; T Oettinger; Robert W Sauerwein; J H Meuwissen
Phase I clinical trial of a recombinant malaria vaccine consisting of the circumsporozoite repeat region of Plasmodium falciparum coupled to hepatitis B surface antigen.
The American journal of tropical medicine and hygiene 1991;45(5):533-8.
1990: Jo H A J Curfs; J W van der Meer; Robert W Sauerwein; Wijnand Eling
Low dosages of interleukin 1 protect mice against lethal cerebral malaria.
The Journal of experimental medicine 1990;172(5):1287-91.
1989: A van Amerongen; Robert W Sauerwein; P J Beckers; Rob H Meloen; J H Meuwissen
Identification of a peptide sequence of the 25 kD surface protein of Plasmodium falciparum recognized by transmission-blocking monoclonal antibodies: implications for synthetic vaccine development.
Parasite immunology 1989;11(4):425-8.