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Grady Saunders

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Malinee Pongsavee; Pimpicha Patmasiriwat; Grady F Saunders
Functional analysis of familial Asp67Glu and Thr1051Ser BRCA1 mutations in breast/ovarian carcinogenesis.
Malinee Pongsavee; Vichanan Yamkamon; Sumana Dakeng; Pornchai O-Charoenrat; Duncan Smith; Grady F Saunders; Pimpicha Patmasiriwat
The BRCA1 3'-UTR: 5711+421T/T_5711+1286T/T genotype is a possible breast and ovarian cancer risk factor.
Anwar Hossain; M Tien Kuo; Grady F Saunders
Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA.

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All Publications

2009: Malinee Pongsavee; Pimpicha Patmasiriwat; Grady F Saunders
Functional analysis of familial Asp67Glu and Thr1051Ser BRCA1 mutations in breast/ovarian carcinogenesis.
International journal of molecular sciences 2009;10(9):4187-97.
2009: Malinee Pongsavee; Vichanan Yamkamon; Sumana Dakeng; Pornchai O-Charoenrat; Duncan Smith; Grady F Saunders; Pimpicha Patmasiriwat
The BRCA1 3'-UTR: 5711+421T/T_5711+1286T/T genotype is a possible breast and ovarian cancer risk factor.
Genetic testing and molecular biomarkers 2009;13(3):307-17.
2006: Anwar Hossain; M Tien Kuo; Grady F Saunders
Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA.
Molecular and cellular biology 2006;26(21):8191-201.
2006: Anwar Hossain; Molly Nixon; M Tien Kuo; Grady F Saunders
N-terminally truncated WT1 protein with oncogenic properties overexpressed in leukemia.
The Journal of biological chemistry 2006;281(38):28122-30.
2004: Nicole Haubst; Joachim Berger; Venugopal Radjendirane; Jochen Graw; Jack Favor; Grady F Saunders; Anastassia Stoykova; Magdalena Götz
Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development.
Development (Cambridge, England) 2004;131(24):6131-40.
2004: Anwar Hossain; Chun Li; Grady F Saunders
Generation of two distinct functional isoforms of dosage-sensitive sex reversal-adrenal hypoplasia congenita-critical region on the X chromosome gene 1 (DAX-1) by alternative splicing.
Molecular endocrinology (Baltimore, Md.) 2004;18(6):1428-37.
2003: Anwar Hossain; Grady F Saunders
Role of Wilms tumor 1 (WT1) in the transcriptional regulation of the Mullerian-inhibiting substance promoter.
Biology of reproduction 2003;69(6):1808-14.
2003: Anwar Hossain; Grady F Saunders
Synergistic cooperation between the beta-catenin signaling pathway and steroidogenic factor 1 in the activation of the Mullerian inhibiting substance type II receptor.
The Journal of biological chemistry 2003;278(29):26511-6.
2003: Lian-Yu Chao; Rajnikant Mishra; Louise C Strong; Grady F Saunders
Missense mutations in the DNA-binding region and termination codon in PAX6.
Human mutation 2003;21(2):138-45.
2002: Rajnikant Mishra; Ivan P Gorlov; Lian-Yu Chao; Sanjaya Singh; Grady F Saunders
PAX6, paired domain influences sequence recognition by the homeodomain.
The Journal of biological chemistry 2002;277(51):49488-94.
2002: Yi-Hong Zhou; Jessica B Zheng; Xun Gu; Grady F Saunders; W K Alfred Yung
Novel PAX6 binding sites in the human genome and the role of repetitive elements in the evolution of gene regulation.
Genome research 2002;12(11):1716-22.
2002: Ivan P Gorlov; Grady F Saunders
A method for isolating alternatively spliced isoforms: isolation of murine Pax6 isoforms.
Analytical biochemistry 2002;308(2):401-4.
2002: Zheng-Ping Xu; Amalia Dutra; Christine Stellrecht; Chengyan Wu; Joram Piatigorsky; Grady F Saunders
Functional and structural characterization of the human gene BHLHB5, encoding a basic helix-loop-helix transcription factor.
Genomics 2002;80(3):311-8.
2002: Pimpicha Patmasiriwat; Kris Bhothisuwan; Olga M Sinilnikova; Sandrine Chopin; Suthida Methakijvaroon; Michael D Badzioch; Puchong Padungsutt; Paiboon Vattanaviboon; Vanchai Vattanasapt; Csilla I Szabo; Grady F Saunders; David E Goldgar; Gilbert M Lenoir
Analysis of breast cancer susceptibility genes BRCA1 and BRCA2 in Thai familial and isolated early-onset breast and ovarian cancer.
Human mutation 2002;20(3):230.
2002: Sanjaya Singh; Rajnikant Mishra; Nelson A Arango; Jian Min Deng; Richard R Behringer; Grady F Saunders
Iris hypoplasia in mice that lack the alternatively spliced Pax6(5a) isoform.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6812-5.
2001: Jessica B Zheng; Yi-Hong Zhou; T Maity; Warren S-L Liao; Grady F Saunders
Activation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1.
Nucleic acids research 2001;29(19):4070-8.
2001: Anwar Hossain; Grady F Saunders
The human sex-determining gene SRY is a direct target of WT1.
The Journal of biological chemistry 2001;276(20):16817-23.
2001: Saurabh Singh; Lian-Yu Chao; Rajnikant Mishra; J Davies; Grady F Saunders
Missense mutation at the C-terminus of PAX6 negatively modulates homeodomain function.
Human molecular genetics 2001;10(9):911-8.
2001: A Zaia; GC Fraizer; Lucio Piantanelli; Grady F Saunders
Transcriptional regulation of the androgen signaling pathway by the Wilms' tumor suppressor gene WT1.
Anticancer research 2001;21(1A):1-10.
2000: Saurabh Singh; Christine Stellrecht; HK Tang; Grady F Saunders
Modulation of PAX6 homeodomain function by the paired domain.
The Journal of biological chemistry 2000;275(23):17306-13.
2000: Y Zhou; Jessica B Zheng; X Gu; W Li; Grady F Saunders
A novel Pax-6 binding site in rodent B1 repetitive elements: coevolution between developmental regulation and repeated elements?
Gene 2000;245(2):319-28.
2000: Lian-Yu Chao; Vicki Huff; Louise C Strong; Grady F Saunders
Mutation in the PAX6 gene in twenty patients with aniridia.
Human mutation 2000;15(4):332-9.
1999: Stephen M Edwards; Michael D Badzioch; R Minter; Rifat A Hamoudi; N Collins; Audrey Ardern-Jones; Anna Dowe; S Osborne; Jo Kelly; RJ Shearer; Douglas F Easton; Grady F Saunders; David P Dearnaley; Rosalind A Eeles
Androgen receptor polymorphisms: association with prostate cancer risk, relapse and overall survival.
International journal of cancer. Journal international du cancer 1999;84(5):458-65.
1999: Pimpicha Patmasiriwat; GC Fraizer; Andrew Lamb; Grady F Saunders
WT1 and GATA1 expression in myelodysplastic syndrome and acute leukemia.
Leukemia 1999;13(6):891-900.
1999: Xing Zhang; G Xing; Grady F Saunders
Proto-oncogene N-myc promoter is down regulated by the Wilms' tumor suppressor gene WT1.
Anticancer research 1999;19(3A):1641-8.
1998: Saurabh Singh; Grady F Saunders
A method for obtaining reporter gene activity and nuclear extracts simultaneously from transiently transfected cells.
Analytical biochemistry 1998;265(1):185-7.
1998: Saurabh Singh; HK Tang; J Y Lee; Grady F Saunders
Truncation mutations in the transactivation region of PAX6 result in dominant-negative mutants.
The Journal of biological chemistry 1998;273(34):21531-41.
1998: HK Tang; Saurabh Singh; Grady F Saunders
Dissection of the transactivation function of the transcription factor encoded by the eye developmental gene PAX6.
The Journal of biological chemistry 1998;273(13):7210-21.
1998: Zheng-Ping Xu; Grady F Saunders
PAX6 intronic sequence targets expression to the spinal cord.
Developmental genetics 1998;23(4):259-63.
1998: Grady F Saunders; Lian-Yu Chao
Four novel and two previously reported mutations of the PAX6 gene in patients with aniridia.
Human mutation 1998;Suppl 1():S207-8.
1998: E Tartaglini; Michael D Badzioch; Lian-Yu Chao; D E Anderson; Grady F Saunders
Three novel germline BRCA1 mutations in early-onset breast and ovarian cancer families.
Human mutation 1998;Suppl 1():S163-6.
1997: GC Fraizer; R Shimamura; Xing Zhang; Grady F Saunders
PAX 8 regulates human WT1 transcription through a novel DNA binding site.
The Journal of biological chemistry 1997;272(49):30678-87.
1997: R Shimamura; GC Fraizer; J Trapman; Grady F Saunders
The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Müllerian-inhibiting substance, and the androgen receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(12 Pt 2):2571-80.
1997: Xing Zhang; G Xing; GC Fraizer; Grady F Saunders
Transactivation of an intronic hematopoietic-specific enhancer of the human Wilms' tumor 1 gene by GATA-1 and c-Myb.
The Journal of biological chemistry 1997;272(46):29272-80.
1997: S M Hewitt; S Hamada; A Monarres; L V Kottical; Grady F Saunders; Timothy J McDonnell
Transcriptional activation of the bcl-2 apoptosis suppressor gene by the paired box transcription factor PAX8.
Anticancer research 1997;17(5A):3211-5.
1997: HK Tang; Lian-Yu Chao; Grady F Saunders
Functional analysis of paired box missense mutations in the PAX6 gene.
Human molecular genetics 1997;6(3):381-6.
1997: Zheng-Ping Xu; Grady F Saunders
Transcriptional regulation of the human PAX6 gene promoter.
The Journal of biological chemistry 1997;272(6):3430-6.
1996: P Patmasiriwat; GC Fraizer; David F Claxton; Andrew Lamb; Grady F Saunders
Expression pattern of WT1 and GATA-1 in AML with chromosome 16q22 abnormalities.
Leukemia 1996;10(7):1127-33.
1996: S M Hewitt; GC Fraizer; Y J Wu; Frank J Rauscher; Grady F Saunders
Differential function of Wilms' tumor gene WT1 splice isoforms in transcriptional regulation.
The Journal of biological chemistry 1996;271(15):8588-92.
1996: S M Hewitt; Grady F Saunders
Differentially spliced exon 5 of the Wilms' tumor gene WT1 modifies gene function.
Anticancer research 1996;16(2):621-6.
1995: W M Mars; P Patmasiriwat; T Maity; Vicki Huff; Michael M Weil; Grady F Saunders
Inheritance of unequal numbers of the genes encoding the human neutrophil defensins HP-1 and HP-3.
The Journal of biological chemistry 1995;270(51):30371-6.
1995: GC Fraizer; P Patmasiriwat; Xing Zhang; Grady F Saunders
Expression of the tumor suppressor gene WT1 in both human and mouse bone marrow.
Blood 1995;86(12):4704-6.
1995: S M Hewitt; S Hamada; Timothy J McDonnell; Frank J Rauscher; Grady F Saunders
Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1.
Cancer research 1995;55(22):5386-9.
1995: S M Hewitt; GC Fraizer; Grady F Saunders
Transcriptional silencer of the Wilms' tumor gene WT1 contains an Alu repeat.
The Journal of biological chemistry 1995;270(30):17908-12.
1995: Y Wu; GC Fraizer; Grady F Saunders
GATA-1 transactivates the WT1 hematopoietic specific enhancer.
The Journal of biological chemistry 1995;270(11):5944-9.
1995: Vicki Huff; Norman Jaffe; Grady F Saunders; Louise C Strong; F Villalba; E C Ruteshouser
WT1 exon 1 deletion/insertion mutations in Wilms tumor patients, associated with di- and trinucleotide repeats and deletion hotspot consensus sequences.
American journal of human genetics 1995;56(1):84-90.
1995: A Martha; Louise C Strong; Robert E Ferrell; Grady F Saunders
Three novel aniridia mutations in the human PAX6 gene.
Human mutation 1995;6(1):44-9.
1994: A Martha; Robert E Ferrell; Helen A Mintz-Hittner; L A Lyons; Grady F Saunders
Paired box mutations in familial and sporadic aniridia predicts truncated aniridia proteins.
American journal of human genetics 1994;54(5):801-11.
1994: GC Fraizer; Y J Wu; S M Hewitt; T Maity; C C Ton; Vicki Huff; Grady F Saunders
Transcriptional regulation of the human Wilms' tumor gene (WT1). Cell type-specific enhancer and promiscuous promoter.
The Journal of biological chemistry 1994;269(12):8892-900.
1994: A D Martha; Robert E Ferrell; Grady F Saunders
Nonsense mutation in the homeobox region of the aniridia gene.
Human mutation 1994;3(3):297-300.
1993: Vicki Huff; Grady F Saunders
Wilms tumor genes.
Biochimica et biophysica acta 1993;1155(3):295-306.
1993: A D Martha; Robert E Ferrell; Grady F Saunders
Dinucleotide repeat polymorphism in the human aniridia (PAX6) gene.
Human molecular genetics 1993;2(11):1982.
1993: D H Kass; M Shen; N B Appel; D E Anderson; Grady F Saunders
Examination of DNA methylation of chromosomal hot spots associated with breast cancer.
Anticancer research 1993;13(5A):1245-51.
1993: Christine Stellrecht; GC Fraizer; C Selvanayagam; Lian-Yu Chao; A Lee; Grady F Saunders
Transcriptional regulation of a hematopoietic proteoglycan core protein gene during hematopoiesis.
The Journal of biological chemistry 1993;268(6):4078-84.
1993: Lian-Yu Chao; Vicki Huff; Gail Tomlinson; V M Riccardi; Louise C Strong; Grady F Saunders
Genetic mosaicism in normal tissues of Wilms' tumour patients.
Nature genetics 1993;3(2):127-31.
1992: L A Lyons; A Martha; Helen A Mintz-Hittner; Grady F Saunders; Robert E Ferrell
Resolution of the two loci for autosomal dominant aniridia, AN1 and AN2, to a single locus on chromosome 11p13.
Genomics 1992;13(4):925-30.
1992: C C Ton; H Miwa; Grady F Saunders
Small eye (Sey): cloning and characterization of the murine homolog of the human aniridia gene.
Genomics 1992;13(2):251-6.
1992: H Miwa; Miloslav Beran; Grady F Saunders
Expression of the Wilms' tumor gene (WT1) in human leukemias.
Leukemia 1992;6(5):405-9.
1992: Robert E Hill; J Favor; B L Hogan; C C Ton; Grady F Saunders; Isabel M Hanson; J Prosser; T Jordan; Nicholas D Hastie; Veronica van Heyningen
Mouse Small eye results from mutations in a paired-like homeobox-containing gene.
Nature 1992;355(6362):750.
1992: H Miwa; Gail Tomlinson; Charles F Timmons; Vicki Huff; Susan Cohn; Louise C Strong; Grady F Saunders
RNA expression of the WT1 gene in Wilms' tumors in relation to histology.
Journal of the National Cancer Institute 1992;84(3):181-7.
1991: Robert E Hill; J Favor; B L Hogan; C C Ton; Grady F Saunders; Isabel M Hanson; J Prosser; T Jordan; Nicholas D Hastie; Veronica van Heyningen
Mouse small eye results from mutations in a paired-like homeobox-containing gene.
Nature 1991;354(6354):522-5.
1991: W H Walker; S L Fitzpatrick; Hugo A Barrera-Saldaña; D Resendez-Perez; Grady F Saunders
The human placental lactogen genes: structure, function, evolution and transcriptional regulation.
Endocrine reviews 1991;12(4):316-28.
1991: Christine Stellrecht; W M Mars; H Miwa; Miloslav Beran; Grady F Saunders
Expression pattern of a hematopoietic proteoglycan core protein gene during human hematopoiesis.
Differentiation; research in biological diversity 1991;48(2):127-35.
1991: Vicki Huff; H Miwa; Daniel A Haber; K M Call; D Housman; Louise C Strong; Grady F Saunders
Evidence for WT1 as a Wilms tumor (WT) gene: intragenic germinal deletion in bilateral WT.
American journal of human genetics 1991;48(5):997-1003.
1991: C C Ton; Vicki Huff; K M Call; Susan Cohn; Louise C Strong; David E Housman; Grady F Saunders
Smallest region of overlap in Wilms tumor deletions uniquely implicates an 11p13 zinc finger gene as the disease locus.
Genomics 1991;10(1):293-7.
1991: Gail Tomlinson; Duane A Compton; Louise C Strong; Grady F Saunders
PCR detection of a BglII RFLP at 11p13.
Nucleic acids research 1991;19(7):1718.
1991: C L Barr; Grady F Saunders
Interferon-gamma-inducible regulation of the human invariant chain gene.
The Journal of biological chemistry 1991;266(6):3475-81.
1991: W M Mars; M Genuardi; H Tsihira; D E Anderson; Grady F Saunders
Genomic changes on the short arm of human chromosome 1 in breast cancer.
Cancer detection and prevention 1991;15(2):145-9.
1990: S L Fitzpatrick; W H Walker; Grady F Saunders
DNA sequences involved in the transcriptional activation of a human placental lactogen gene.
Molecular endocrinology (Baltimore, Md.) 1990;4(12):1815-26.
1990: A K Levinson; D E Johnson; Louise C Strong; Sen Pathak; Vicki Huff; Grady F Saunders
Familial renal cell carcinoma: hereditary or coincidental?
The Journal of urology 1990;144(4):849-51.
1990: W H Walker; S L Fitzpatrick; Grady F Saunders
Human placental lactogen transcriptional enhancer. Tissue specificity and binding with specific proteins.
The Journal of biological chemistry 1990;265(22):12940-8.
1990: W M Mars; Grady F Saunders
Chromosomal abnormalities in human breast cancer.
Cancer metastasis reviews 1990;9(1):35-43.
1990: Vicki Huff; A Meadows; V M Riccardi; Louise C Strong; Grady F Saunders
Parental origin of de novo constitutional deletions of chromosomal band 11p13.
American journal of human genetics 1990;47(1):155-60.
1990: P Selvanayagam; Louise C Strong; Grady F Saunders; Bart Barlogie
A rare BclI RFLP in the putative oncogene bcl-1 locus.
Nucleic acids research 1990;18(6):1665.
1990: C C Ton; Vicki Huff; Michael M Weil; Louise C Strong; Grady F Saunders
A BglII RFLP detected by the probe JA8-1 at human chromosome band 11p13 (D11S417).
Nucleic acids research 1990;18(4):1084.
1990: Michael M Weil; Vicki Huff; Duane A Compton; Louise C Strong; Grady F Saunders
An XmnI polymorphism detected by a human genomic clone from chromosomal band 11p13 [D11S416].
Nucleic acids research 1990;18(3):689.
1990: Duane A Compton; Michael M Weil; L Bonetta; A Huang; C Jones; Herman Yeger; Bryan R G Williams; Louise C Strong; Grady F Saunders
Definition of the limits of the Wilms tumor locus on human chromosome 11p13.
Genomics 1990;6(2):309-15.
1990: Vicki Huff; Duane A Compton; Louise C Strong; Grady F Saunders
A panel of restriction fragment length polymorphisms for chromosomal band 11p13.
Human genetics 1990;84(3):253-7.
1989: J W White; M Sobnosky; B L Rogers; W H Walker; Grady F Saunders
Nucleotide sequence of a transcriptional enhancer located 2.2 kb 3' of a human placental lactogen-encoding gene.
Gene 1989;84(2):521-2.
1989: Christine Stellrecht; Grady F Saunders
Nucleotide sequence of a cDNA encoding a hemopoietic proteoglycan core protein.
Nucleic acids research 1989;17(18):7523.
1989: M Genuardi; H Tsihira; D E Anderson; Grady F Saunders
Distal deletion of chromosome Ip in ductal carcinoma of the breast.
American journal of human genetics 1989;45(1):73-82.
1988: Duane A Compton; Michael M Weil; C Jones; V M Riccardi; Louise C Strong; Grady F Saunders
Long range physical map of the Wilms' tumor-aniridia region on human chromosome 11.
Cell 1988;55(5):827-36.
1988: Vicki Huff; Duane A Compton; Lian-Yu Chao; Louise C Strong; C F Geiser; Grady F Saunders
Lack of linkage of familial Wilms' tumour to chromosomal band 11p13.
Nature 1988;336(6197):377-8.
1988: W M Mars; P van Tuinen; Harry A Drabkin; J W White; Grady F Saunders
A myeloid-related sequence that localizes to human chromosome 8q21.1-22.
Blood 1988;71(6):1713-9.
1988: C J Su; J W White; W H Li; C C Luo; Marsha L Frazier; Grady F Saunders; L Chan
Structure and evolution of somatostatin genes.
Molecular endocrinology (Baltimore, Md.) 1988;2(3):209-16.
1988: P Selvanayagam; M Blick; F Narni; P van Tuinen; David Ledbetter; Raymond Alexanian; Grady F Saunders; Bart Barlogie
Alteration and abnormal expression of the c-myc oncogene in human multiple myeloma.
Blood 1988;71(1):30-5.
1987: H Gondo; J Kudo; J W White; C Barr; P Selvanayagam; Grady F Saunders
Differential expression of the human thymosin-beta 4 gene in lymphocytes, macrophages, and granulocytes.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(11):3840-8.
1987: Vicki Huff; Duane A Compton; W Lewis; C Jones; Louise C Strong; Grady F Saunders
An EcoRI polymorphism associated with a human genomic clone from band 11p13.
Nucleic acids research 1987;15(18):7651.
1987: D D Dao; W T Schroeder; Lian-Yu Chao; H Kikuchi; Louise C Strong; V M Riccardi; S Pathak; W W Nichols; W H Lewis; Grady F Saunders
Genetic mechanisms of tumor-specific loss of 11p DNA sequences in Wilms tumor.
American journal of human genetics 1987;41(2):202-17.
1987: F Narni; P Selvanayagam; Bart Barlogie; Grady F Saunders
HLA-associated invariant chain gene expression in human B cell neoplasia.
Leukemia 1987;1(6):504-7.
1987: W T Schroeder; Lian-Yu Chao; D D Dao; Louise C Strong; S Pathak; V Riccardi; W H Lewis; Grady F Saunders
Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors.
American journal of human genetics 1987;40(5):413-20.
1987: W M Mars; Christine Stellrecht; Sanford A Stass; Marsha L Frazier; Grady F Saunders
Localization of an abundant myeloid mRNA to individual leukocytes in mixed cell populations.
Leukemia 1987;1(3):167-72.
1987: W M Mars; Christine Stellrecht; J W White; Grady F Saunders
Localization of an abundant myeloid-related sequence.
Acta haematologica 1987;78 Suppl 1():11-7.
1986: F Narni; J Kudo; W Mars; B Calabretta; D L Florine; Bart Barlogie; Grady F Saunders
HLA-DR-associated invariant chain is highly expressed in chronic lymphocytic leukemia.
Blood 1986;68(2):372-7.
1985: J Kudo; L Y Chao; F Narni; Grady F Saunders
Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens.
Nucleic acids research 1985;13(24):8827-41.
1985: W M Mars; D L Florine; Moshe Talpaz; Grady F Saunders
Preferentially expressed genes in chronic myelogenous leukemia.
Blood 1985;65(5):1218-25.