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Grady Saunders

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Molecular Sequence Data

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Gene Expression Regulation

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Co-Publications
Name
21
Strong, Louise
16
Huff, Vicki
12
Chao, Lian-Yu
12
Fraizer, GC
7
Compton, Duane
7
Stellrecht, Christine
6
Hossain, Anwar
5
Ferrell, Robert
5
Weil, Michael
5
Singh, Saurabh
4
Patmasiriwat, Pimpicha
4
Mishra, Rajnikant
4
Tang, HK
4
Zhang, Xing
3
Zheng, Jessica

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Publications

TOP 3
Pongsavee Malinee; Patmasiriwat Pimpicha; Saunders Grady F
Functional Analysis of Familial Asp67Glu and Thr1051Ser BRCA1 Mutations in Breast/Ovarian Carcinogenesis.
Pongsavee Malinee; Yamkamon Vichanan; Dakeng Sumana; O-charoenrat Pornchai; Smith Duncan R; Saunders Grady F; Patmasiriwat Pimpicha
The BRCA1 3'-UTR: 5711+421T/T_5711+1286T/T genotype is a possible breast and ovarian cancer risk factor.
Hossain Anwar; Kuo Macus T; Saunders Grady F
Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA.

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All Publications

2009: Pongsavee Malinee; Patmasiriwat Pimpicha; Saunders Grady F
Functional Analysis of Familial Asp67Glu and Thr1051Ser BRCA1 Mutations in Breast/Ovarian Carcinogenesis.
International journal of molecular sciences 2009;10(9):4187-97.
2009: Pongsavee Malinee; Yamkamon Vichanan; Dakeng Sumana; O-charoenrat Pornchai; Smith Duncan R; Saunders Grady F; Patmasiriwat Pimpicha
The BRCA1 3'-UTR: 5711+421T/T_5711+1286T/T genotype is a possible breast and ovarian cancer risk factor.
Genetic testing and molecular biomarkers 2009;13(3):307-17.
2006: Hossain Anwar; Kuo Macus T; Saunders Grady F
Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA.
Molecular and cellular biology 2006;26(21):8191-201.
2006: Hossain Anwar; Nixon Molly; Kuo Macus T; Saunders Grady F
N-terminally truncated WT1 protein with oncogenic properties overexpressed in leukemia.
The Journal of biological chemistry 2006;281(38):28122-30.
2004: Haubst Nicole; Berger Joachim; Radjendirane Venugopal; Graw Jochen; Favor Jack; Saunders Grady F; Stoykova Anastassia; Götz Magdalena
Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development.
Development (Cambridge, England) 2004;131(24):6131-40.
2004: Hossain Anwar; Li Chun; Saunders Grady F
Generation of two distinct functional isoforms of dosage-sensitive sex reversal-adrenal hypoplasia congenita-critical region on the X chromosome gene 1 (DAX-1) by alternative splicing.
Molecular endocrinology (Baltimore, Md.) 2004;18(6):1428-37.
2003: Hossain Anwar; Saunders Grady F
Role of Wilms tumor 1 (WT1) in the transcriptional regulation of the Mullerian-inhibiting substance promoter.
Biology of reproduction 2003;69(6):1808-14.
2003: Hossain Anwar; Saunders Grady F
Synergistic cooperation between the beta-catenin signaling pathway and steroidogenic factor 1 in the activation of the Mullerian inhibiting substance type II receptor.
The Journal of biological chemistry 2003;278(29):26511-6.
2003: Chao Lian-Yu; Mishra Rajnikant; Strong Louise C; Saunders Grady F
Missense mutations in the DNA-binding region and termination codon in PAX6.
Human mutation 2003;21(2):138-45.
2002: Mishra Rajnikant; Gorlov Ivan P; Chao Lian Y; Singh Sanjaya; Saunders Grady F
PAX6, paired domain influences sequence recognition by the homeodomain.
The Journal of biological chemistry 2002;277(51):49488-94.
2002: Zhou Yi-Hong; Zheng Jessica B; Gu Xun; Saunders Grady F; Yung W-K Alfred
Novel PAX6 binding sites in the human genome and the role of repetitive elements in the evolution of gene regulation.
Genome research 2002;12(11):1716-22.
2002: Gorlov Ivan P; Saunders Grady F
A method for isolating alternatively spliced isoforms: isolation of murine Pax6 isoforms.
Analytical biochemistry 2002;308(2):401-4.
2002: Xu Zheng-Ping; Dutra Amalia; Stellrecht Christine M; Wu Chengyan; Piatigorsky Joram; Saunders Grady F
Functional and structural characterization of the human gene BHLHB5, encoding a basic helix-loop-helix transcription factor.
Genomics 2002;80(3):311-8.
2002: Patmasiriwat Pimpicha; Bhothisuwan Kris; Sinilnikova Olga M; Chopin Sandrine; Methakijvaroon Suthida; Badzioch Michael; Padungsutt Puchong; Vattanaviboon Phantip; Vattanasapt Vanchai; Szabo Csilla; Saunders Grady F; Goldgar David; Lenoir Gilbert M
Analysis of breast cancer susceptibility genes BRCA1 and BRCA2 in Thai familial and isolated early-onset breast and ovarian cancer.
Human mutation 2002;20(3):230.
2002: Singh Sanjaya; Mishra Rajnikant; Arango Nelson A; Deng Jian Min; Behringer Richard R; Saunders Grady F
Iris hypoplasia in mice that lack the alternatively spliced Pax6(5a) isoform.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6812-5.
2001: Zheng J B; Zhou Y H; Maity T; Liao W S; Saunders G F
Activation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1.
Nucleic acids research 2001;29(19):4070-8.
2001: Hossain A; Saunders G F
The human sex-determining gene SRY is a direct target of WT1.
The Journal of biological chemistry 2001;276(20):16817-23.
2001: Singh S; Chao L Y; Mishra R; Davies J; Saunders G F
Missense mutation at the C-terminus of PAX6 negatively modulates homeodomain function.
Human molecular genetics 2001;10(9):911-8.
2001: Zaia A; Fraizer G C; Piantanelli L; Saunders G F
Transcriptional regulation of the androgen signaling pathway by the Wilms' tumor suppressor gene WT1.
Anticancer research 2001;21(1A):1-10.
2000: Singh S; Stellrecht C M; Tang H K; Saunders G F
Modulation of PAX6 homeodomain function by the paired domain.
The Journal of biological chemistry 2000;275(23):17306-13.
2000: Zhou Y; Zheng J B; Gu X; Li W; Saunders G F
A novel Pax-6 binding site in rodent B1 repetitive elements: coevolution between developmental regulation and repeated elements?
Gene 2000;245(2):319-28.
2000: Chao L Y; Huff V; Strong L C; Saunders G F
Mutation in the PAX6 gene in twenty patients with aniridia.
Human mutation 2000;15(4):332-9.
1999: Edwards S M; Badzioch M D; Minter R; Hamoudi R; Collins N; Ardern-Jones A; Dowe A; Osborne S; Kelly J; Shearer R; Easton D F; Saunders G F; Dearnaley D P; Eeles R A
Androgen receptor polymorphisms: association with prostate cancer risk, relapse and overall survival.
International journal of cancer. Journal international du cancer 1999;84(5):458-65.
1999: Patmasiriwat P; Fraizer G; Kantarjian H; Saunders G F
WT1 and GATA1 expression in myelodysplastic syndrome and acute leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13(6):891-900.
1999: Zhang X; Xing G; Saunders G F
Proto-oncogene N-myc promoter is down regulated by the Wilms' tumor suppressor gene WT1.
Anticancer research 1999;19(3A):1641-8.
1998: Singh S; Saunders G F
A method for obtaining reporter gene activity and nuclear extracts simultaneously from transiently transfected cells.
Analytical biochemistry 1998;265(1):185-7.
1998: Singh S; Tang H K; Lee J Y; Saunders G F
Truncation mutations in the transactivation region of PAX6 result in dominant-negative mutants.
The Journal of biological chemistry 1998;273(34):21531-41.
1998: Tang H K; Singh S; Saunders G F
Dissection of the transactivation function of the transcription factor encoded by the eye developmental gene PAX6.
The Journal of biological chemistry 1998;273(13):7210-21.
1998: Xu Z P; Saunders G F
PAX6 intronic sequence targets expression to the spinal cord.
Developmental genetics 1998;23(4):259-63.
1998: Saunders G F; Chao L Y
Four novel and two previously reported mutations of the PAX6 gene in patients with aniridia.
Human mutation 1998;Suppl 1():S207-8.
1998: Tartaglini E; Badzioch M D; Chao L Y; Anderson D E; Saunders G F
Three novel germline BRCA1 mutations in early-onset breast and ovarian cancer families.
Human mutation 1998;Suppl 1():S163-6.
1997: Shimamura R; Fraizer G C; Trapman J; Lau YfC; Saunders G F
The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Müllerian-inhibiting substance, and the androgen receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(12 Pt 2):2571-80.
1997: Fraizer G C; Shimamura R; Zhang X; Saunders G F
PAX 8 regulates human WT1 transcription through a novel DNA binding site.
The Journal of biological chemistry 1997;272(49):30678-87.
1997: Zhang X; Xing G; Fraizer G C; Saunders G F
Transactivation of an intronic hematopoietic-specific enhancer of the human Wilms' tumor 1 gene by GATA-1 and c-Myb.
The Journal of biological chemistry 1997;272(46):29272-80.
1997: Hewitt S M; Hamada S; Monarres A; Kottical L V; Saunders G F; McDonnell T J
Transcriptional activation of the bcl-2 apoptosis suppressor gene by the paired box transcription factor PAX8.
Anticancer research 1997;17(5A):3211-5.
1997: Tang H K; Chao L Y; Saunders G F
Functional analysis of paired box missense mutations in the PAX6 gene.
Human molecular genetics 1997;6(3):381-6.
1997: Xu Z P; Saunders G F
Transcriptional regulation of the human PAX6 gene promoter.
The Journal of biological chemistry 1997;272(6):3430-6.
1996: Patmasiriwat P; Fraizer G C; Claxton D; Kantarjian H; Saunders G F
Expression pattern of WT1 and GATA-1 in AML with chromosome 16q22 abnormalities.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1996;10(7):1127-33.
1996: Hewitt S M; Fraizer G C; Wu Y J; Rauscher F J; Saunders G F
Differential function of Wilms' tumor gene WT1 splice isoforms in transcriptional regulation.
The Journal of biological chemistry 1996;271(15):8588-92.
1996: Hewitt S M; Saunders G F
Differentially spliced exon 5 of the Wilms' tumor gene WT1 modifies gene function.
Anticancer research 1996;16(2):621-6.
1995: Fraizer G C; Patmasiriwat P; Zhang X; Saunders G F
Expression of the tumor suppressor gene WT1 in both human and mouse bone marrow.
Blood 1995;86(12):4704-6.
1995: Mars W M; Patmasiriwat P; Maity T; Huff V; Weil M M; Saunders G F
Inheritance of unequal numbers of the genes encoding the human neutrophil defensins HP-1 and HP-3.
The Journal of biological chemistry 1995;270(51):30371-6.
1995: Hewitt S M; Hamada S; McDonnell T J; Rauscher F J; Saunders G F
Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1.
Cancer research 1995;55(22):5386-9.
1995: Hewitt S M; Fraizer G C; Saunders G F
Transcriptional silencer of the Wilms' tumor gene WT1 contains an Alu repeat.
The Journal of biological chemistry 1995;270(30):17908-12.
1995: Wu Y; Fraizer G C; Saunders G F
GATA-1 transactivates the WT1 hematopoietic specific enhancer.
The Journal of biological chemistry 1995;270(11):5944-9.
1995: Huff V; Jaffe N; Saunders G F; Strong L C; Villalba F; Ruteshouser E C
WT1 exon 1 deletion/insertion mutations in Wilms tumor patients, associated with di- and trinucleotide repeats and deletion hotspot consensus sequences.
American journal of human genetics 1995;56(1):84-90.
1995: Martha A; Strong L C; Ferrell R E; Saunders G F
Three novel aniridia mutations in the human PAX6 gene.
Human mutation 1995;6(1):44-9.
1994: Martha A; Ferrell R E; Mintz-Hittner H; Lyons L A; Saunders G F
Paired box mutations in familial and sporadic aniridia predicts truncated aniridia proteins.
American journal of human genetics 1994;54(5):801-11.
1994: Fraizer G C; Wu Y J; Hewitt S M; Maity T; Ton C C; Huff V; Saunders G F
Transcriptional regulation of the human Wilms' tumor gene (WT1). Cell type-specific enhancer and promiscuous promoter.
The Journal of biological chemistry 1994;269(12):8892-900.
1994: Martha A D; Ferrell R E; Saunders G F
Nonsense mutation in the homeobox region of the aniridia gene.
Human mutation 1994;3(3):297-300.
1993: Huff V; Saunders G F
Wilms tumor genes.
Biochimica et biophysica acta 1993;1155(3):295-306.
1993: Martha A D; Ferrell R E; Saunders G F
Dinucleotide repeat polymorphism in the human aniridia (PAX6) gene.
Human molecular genetics 1993;2(11):1982.
1993: Kass D H; Shen M; Appel N B; Anderson D E; Saunders G F
Examination of DNA methylation of chromosomal hot spots associated with breast cancer.
Anticancer research 1993;13(5A):1245-51.
1993: Stellrecht C M; Fraizer G; Selvanayagam C; Chao L Y; Lee A; Saunders G F
Transcriptional regulation of a hematopoietic proteoglycan core protein gene during hematopoiesis.
The Journal of biological chemistry 1993;268(6):4078-84.
1993: Chao L Y; Huff V; Tomlinson G; Riccardi V M; Strong L C; Saunders G F
Genetic mosaicism in normal tissues of Wilms' tumour patients.
Nature genetics 1993;3(2):127-31.
1992: Lyons L A; Martha A; Mintz-Hittner H A; Saunders G F; Ferrell R E
Resolution of the two loci for autosomal dominant aniridia, AN1 and AN2, to a single locus on chromosome 11p13.
Genomics 1992;13(4):925-30.
1992: Ton C C; Miwa H; Saunders G F
Small eye (Sey): cloning and characterization of the murine homolog of the human aniridia gene.
Genomics 1992;13(2):251-6.
1992: Miwa H; Beran M; Saunders G F
Expression of the Wilms' tumor gene (WT1) in human leukemias.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1992;6(5):405-9.
1992: Hill R E; Favor J; Hogan B L; Ton C C; Saunders G F; Hanson I M; Prosser J; Jordan T; Hastie N D; van Heyningen V
Mouse Small eye results from mutations in a paired-like homeobox-containing gene.
Nature 1992;355(6362):750.
1992: Miwa H; Tomlinson G E; Timmons C F; Huff V; Cohn S L; Strong L C; Saunders G F
RNA expression of the WT1 gene in Wilms' tumors in relation to histology.
Journal of the National Cancer Institute 1992;84(3):181-7.
1991: Hill R E; Favor J; Hogan B L; Ton C C; Saunders G F; Hanson I M; Prosser J; Jordan T; Hastie N D; van Heyningen V
Mouse small eye results from mutations in a paired-like homeobox-containing gene.
Nature 1991;354(6354):522-5.
1991: Walker W H; Fitzpatrick S L; Barrera-Saldaña H A; Resendez-Perez D; Saunders G F
The human placental lactogen genes: structure, function, evolution and transcriptional regulation.
Endocrine reviews 1991;12(4):316-28.
1991: Stellrecht C M; Mars W M; Miwa H; Beran M; Saunders G F
Expression pattern of a hematopoietic proteoglycan core protein gene during human hematopoiesis.
Differentiation; research in biological diversity 1991;48(2):127-35.
1991: Huff V; Miwa H; Haber D A; Call K M; Housman D; Strong L C; Saunders G F
Evidence for WT1 as a Wilms tumor (WT) gene: intragenic germinal deletion in bilateral WT.
American journal of human genetics 1991;48(5):997-1003.
1991: Ton C C; Huff V; Call K M; Cohn S; Strong L C; Housman D E; Saunders G F
Smallest region of overlap in Wilms tumor deletions uniquely implicates an 11p13 zinc finger gene as the disease locus.
Genomics 1991;10(1):293-7.
1991: Tomlinson G E; Compton D A; Strong L C; Saunders G F
PCR detection of a BglII RFLP at 11p13.
Nucleic acids research 1991;19(7):1718.
1991: Barr C L; Saunders G F
Interferon-gamma-inducible regulation of the human invariant chain gene.
The Journal of biological chemistry 1991;266(6):3475-81.
1991: Mars W M; Genuardi M; Tsihira H; Anderson D E; Saunders G F
Genomic changes on the short arm of human chromosome 1 in breast cancer.
Cancer detection and prevention 1991;15(2):145-9.
1990: Fitzpatrick S L; Walker W H; Saunders G F
DNA sequences involved in the transcriptional activation of a human placental lactogen gene.
Molecular endocrinology (Baltimore, Md.) 1990;4(12):1815-26.
1990: Levinson A K; Johnson D E; Strong L C; Pathak S; Huff V; Saunders G F
Familial renal cell carcinoma: hereditary or coincidental?
The Journal of urology 1990;144(4):849-51.
1990: Walker W H; Fitzpatrick S L; Saunders G F
Human placental lactogen transcriptional enhancer. Tissue specificity and binding with specific proteins.
The Journal of biological chemistry 1990;265(22):12940-8.
1990: Mars W M; Saunders G F
Chromosomal abnormalities in human breast cancer.
Cancer metastasis reviews 1990;9(1):35-43.
1990: Huff V; Meadows A; Riccardi V M; Strong L C; Saunders G F
Parental origin of de novo constitutional deletions of chromosomal band 11p13.
American journal of human genetics 1990;47(1):155-60.
1990: Selvanayagam P; Strong L C; Saunders G F; Barlogie B
A rare BclI RFLP in the putative oncogene bcl-1 locus.
Nucleic acids research 1990;18(6):1665.
1990: Compton D A; Weil M M; Bonetta L; Huang A; Jones C; Yeger H; Williams B R; Strong L C; Saunders G F
Definition of the limits of the Wilms tumor locus on human chromosome 11p13.
Genomics 1990;6(2):309-15.
1990: Ton C C; Huff V; Weil M M; Strong L C; Saunders G F
A BglII RFLP detected by the probe JA8-1 at human chromosome band 11p13 (D11S417).
Nucleic acids research 1990;18(4):1084.
1990: Weil M M; Huff V; Compton D A; Strong L C; Saunders G F
An XmnI polymorphism detected by a human genomic clone from chromosomal band 11p13 [D11S416]
Nucleic acids research 1990;18(3):689.
1990: Huff V; Compton D A; Strong L C; Saunders G F
A panel of restriction fragment length polymorphisms for chromosomal band 11p13.
Human genetics 1990;84(3):253-7.
1989: White J W; Sobnosky M; Rogers B L; Walker W H; Saunders G F
Nucleotide sequence of a transcriptional enhancer located 2.2 kb 3' of a human placental lactogen-encoding gene.
Gene 1989;84(2):521-2.
1989: Stellrecht C M; Saunders G F
Nucleotide sequence of a cDNA encoding a hemopoietic proteoglycan core protein.
Nucleic acids research 1989;17(18):7523.
1989: Genuardi M; Tsihira H; Anderson D E; Saunders G F
Distal deletion of chromosome Ip in ductal carcinoma of the breast.
American journal of human genetics 1989;45(1):73-82.
1988: Compton D A; Weil M M; Jones C; Riccardi V M; Strong L C; Saunders G F
Long range physical map of the Wilms' tumor-aniridia region on human chromosome 11.
Cell 1988;55(5):827-36.
1988: Huff V; Compton D A; Chao L Y; Strong L C; Geiser C F; Saunders G F
Lack of linkage of familial Wilms' tumour to chromosomal band 11p13.
Nature 1988;336(6197):377-8.
1988: Mars W M; van Tuinen P; Drabkin H A; White J W; Saunders G F
A myeloid-related sequence that localizes to human chromosome 8q21.1-22.
Blood 1988;71(6):1713-9.
1988: Su C J; White J W; Li W H; Luo C C; Frazier M L; Saunders G F; Chan L
Structure and evolution of somatostatin genes.
Molecular endocrinology (Baltimore, Md.) 1988;2(3):209-16.
1988: Selvanayagam P; Blick M; Narni F; van Tuinen P; Ledbetter D H; Alexanian R; Saunders G F; Barlogie B
Alteration and abnormal expression of the c-myc oncogene in human multiple myeloma.
Blood 1988;71(1):30-5.
1987: Gondo H; Kudo J; White J W; Barr C; Selvanayagam P; Saunders G F
Differential expression of the human thymosin-beta 4 gene in lymphocytes, macrophages, and granulocytes.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(11):3840-8.
1987: Huff V; Compton D; Lewis W; Jones C; Strong L C; Saunders G F
An EcoRI polymorphism associated with a human genomic clone from band 11p13.
Nucleic acids research 1987;15(18):7651.
1987: Dao D D; Schroeder W T; Chao L Y; Kikuchi H; Strong L C; Riccardi V M; Pathak S; Nichols W W; Lewis W H; Saunders G F
Genetic mechanisms of tumor-specific loss of 11p DNA sequences in Wilms tumor.
American journal of human genetics 1987;41(2):202-17.
1987: Narni F; Selvanayagam P; Barlogie B; Saunders G F
HLA-associated invariant chain gene expression in human B cell neoplasia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1987;1(6):504-7.
1987: Schroeder W T; Chao L Y; Dao D D; Strong L C; Pathak S; Riccardi V; Lewis W H; Saunders G F
Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors.
American journal of human genetics 1987;40(5):413-20.
1987: Mars W M; Stellrecht C M; Stass S; Frazier M L; Saunders G F
Localization of an abundant myeloid mRNA to individual leukocytes in mixed cell populations.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1987;1(3):167-72.
1987: Mars W M; Stellrecht C M; White J W; Saunders G F
Localization of an abundant myeloid-related sequence.
Acta haematologica 1987;78 Suppl 1():11-7.
1986: Narni F; Kudo J; Mars W; Calabretta B; Florine D L; Barlogie B; Saunders G F
HLA-DR-associated invariant chain is highly expressed in chronic lymphocytic leukemia.
Blood 1986;68(2):372-7.
1985: Kudo J; Chao L Y; Narni F; Saunders G F
Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens.
Nucleic acids research 1985;13(24):8827-41.
1985: Mars W M; Florine D L; Talpaz M; Saunders G F
Preferentially expressed genes in chronic myelogenous leukemia.
Blood 1985;65(5):1218-25.

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