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Dieter Saur

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Laura Conradt; Annika Henrich; Oliver H Krämer; Marina Lesina; Maximilian Reichert; Dieter Saur; Roland M Schmid; Hana Algül; Matthias Wirth; Günter Schneider
Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death.
Stefan Eser; Irene Esposito; Kathleen Gottschalk; Maren Hieber; Alexander J Kind; Sabine Klein; Bo Kong; Marlena Messer; Christoph W Michalski; Lena Rad; Roland Rad; Nina Reiff; Dario R Alessi; Andreas Arbeiter; Manuela Baccarini; Melanie Dobler; Anna Melissa Schlitter; Roland M Schmid; Günter Schneider; Angelika Schnieke; Barbara Seidler; Dieter Saur
Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer.
Hong Zhang; Walter Halangk; Magdalena U Kurkowski; Marina Lesina; Joseph P Mizgerd; Patrick Neuhöfer; Björn Rabe; Sara Regnér; Stefan Rose-John; Dieter Saur; Roland M Schmid; Liang Song; Henrik Thorlacius; Matthias Treiber; Thomas Wartmann; Gregor Weirich; Akihiko Yoshimura; Hana Algül
IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality.

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2013: Laura Conradt; Annika Henrich; Oliver H Krämer; Marina Lesina; Maximilian Reichert; Dieter Saur; Roland M Schmid; Hana Algül; Matthias Wirth; Günter Schneider
Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death.
International journal of cancer. Journal international du cancer 2013;132(10):2248-57.
2013: Stefan Eser; Irene Esposito; Kathleen Gottschalk; Maren Hieber; Alexander J Kind; Sabine Klein; Bo Kong; Marlena Messer; Christoph W Michalski; Lena Rad; Roland Rad; Nina Reiff; Dario R Alessi; Andreas Arbeiter; Manuela Baccarini; Melanie Dobler; Anna Melissa Schlitter; Roland M Schmid; Günter Schneider; Angelika Schnieke; Barbara Seidler; Dieter Saur
Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer.
Cancer cell 2013;23(3):406-20.
2013: Hong Zhang; Walter Halangk; Magdalena U Kurkowski; Marina Lesina; Joseph P Mizgerd; Patrick Neuhöfer; Björn Rabe; Sara Regnér; Stefan Rose-John; Dieter Saur; Roland M Schmid; Liang Song; Henrik Thorlacius; Matthias Treiber; Thomas Wartmann; Gregor Weirich; Akihiko Yoshimura; Hana Algül
IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality.
The Journal of clinical investigation 2013;123(3):1019-31.
2013: Sandra Diersch; Philipp Eser; Stefan Eser; Irene Esposito; Marlena Messer; Philipp Pagel; Mariel C Paul; Maximilian Reichert; Dieter Saur; Roland M Schmid; Barbara Seidler; Melanie Szameitat; Patrick Wenzel; Günter Schneider
Efemp1 and p27(Kip1) modulate responsiveness of pancreatic cancer cells towards a dual PI3K/mTOR inhibitor in preclinical models.
Oncotarget 2013;4(2):277-88.
2013: Sabine Klein; Roland Rad; Michael Rohn; Hans-Dieter Allescher; Robert Feil; Franz Hofmann; Anna Kettenberger; Michael Schemann; Roland M Schmid; Günter Schneider; Barbara Seidler; Andrei Sibaev; Martin Storr; Jean-Marie Vanderwinden; Dieter Saur
Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity.
Nature communications 2013;4():1630.
2013: Claudia Merkl; Anna Pertek; Nathalie Riesen; Anja Saalfrank; Dieter Saur; Stefan Eser; Markus Sebastian Hardt; Antonio Iglesias; Alexander Kind; Ralf Kühn; Wolfgang Wurst; Angelika Schnieke
Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector.
PloS one 2013;8(1):e55170.
2012: Tatiana Flisikowska; Barbara Kessler; Alexander Kind; Mayuko Kurome; Martina Landmann; Claudia Merkl; Nousin Rezaei; Oswald Rottmann; Dieter Saur; Roland M Schmid; Günter Schneider; Xinxin Cui; Stefan Eser; Hagen Wieland; Eckhard Wolf; Valeri Zakhartchenko; Angelika Schnieke
A porcine model of familial adenomatous polyposis.
Gastroenterology 2012;143(5):1173-5.e1-7.
2012: Alexander von Werder; Roland M Schmid; Günter Schneider; Barbara Seidler; Dieter Saur
Production of avian retroviruses and tissue-specific somatic retroviral gene transfer in vivo using the RCAS/TVA system.
Nature protocols 2012;7(6):1167-83.
2012: Wajana L Labisso; Dieter Saur; Roland M Schmid; Angelika Schnieke; Roland H Stauber; Natasa Stojanovic; Matthias Wirth; Oliver H Krämer; Günter Schneider
MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors.
Cell cycle (Georgetown, Tex.) 2012;11(8):1593-602.
2012: Anurag Kumar Singh; Beate Spiessberger; Jörg W Wegener; Pascal Weinmeister; Fang Xiao; Wen Zheng; Sabine Klein; Dagmar Krueger; Robert Lukowski; Dieter Saur; Michael Schemann; Ursula Seidler; Franz Hofmann
Neuronal cGMP kinase I is essential for stimulation of duodenal bicarbonate secretion by luminal acid.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(4):1745-54.
2012: Günter Schneider; Oliver H Krämer; Dieter Saur
A ZEB1-HDAC pathway enters the epithelial to mesenchymal transition world in pancreatic cancer.
Gut 2012;61(3):329-30.
2011: Alexander von Werder; Hans-Dieter Allescher; Ralph Fritsch; Franz Hofmann; Martina Mayr; Daniela Oesterle; Michael Schemann; Jens Schlossmann; Roland M Schmid; Günter Schneider; Barbara Seidler; Dieter Saur
Truncated IRAG variants modulate cGMP-mediated inhibition of human colonic smooth muscle cell contraction.
American journal of physiology. Cell physiology 2011;301(6):C1445-57.
2011: Laura Conradt; Sandra Diersch; Stefan Eser; Klaus Godl; Jörg Kleeff; Christoph W Michalski; Dieter Saur; Christoph Schaab; Roland M Schmid; Angelika Schnieke; Andreas Tebbe; Günter Schneider
Disclosure of erlotinib as a multikinase inhibitor in pancreatic ductal adenocarcinoma.
Neoplasia (New York, N.Y.) 2011;13(11):1026-34.
2011: Stefan Eser; Irene Esposito; Alexander Meining; Marlena Messer; Philipp Pagel; Roland M Schmid; Günter Schneider; Angelika Schnieke; Barbara Seidler; Roger Vogelmann; Johannes von Burstin; Alexander von Werder; Hana Algül; Monther Bajbouj; Philipp Eser; Dieter Saur
In vivo diagnosis of murine pancreatic intraepithelial neoplasia and early-stage pancreatic cancer by molecular imaging.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(24):9945-50.
2011: Günter Schneider; Oliver H Krämer; Roland M Schmid; Dieter Saur
Acetylation as a transcriptional control mechanism-HDACs and HATs in pancreatic ductal adenocarcinoma.
Journal of gastrointestinal cancer 2011;42(2):85-92.
2011: Günter Schneider; Dieter Saur
Mesenchymal stem cells: therapeutic potential for acute pancreatitis.
Gastroenterology 2011;140(3):779-82.
2011: Susanne Schüler; Sandra Diersch; Rainer Hamacher; Roland M Schmid; Dieter Saur; Günter Schneider
SKP2 confers resistance of pancreatic cancer cells towards TRAIL-induced apoptosis.
International journal of oncology 2011;38(1):219-25.
2011: Matthias Wirth; Petra Fritsche; Natasa Stojanovic; Martina Brandl; Stephanie Jaeckel; Roland M Schmid; Dieter Saur; Günter Schneider
A simple and cost-effective method to transfect small interfering RNAs into pancreatic cancer cell lines using polyethylenimine.
Pancreas 2011;40(1):144-50.
2010: Martina Brandl; Barbara Seidler; Ferdinand Haller; Jerzy Adamski; Roland M Schmid; Dieter Saur; Günter Schneider
IKK(α) controls canonical TGF(ß)-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells.
Journal of cell science 2010;123(Pt 24):4231-9.
2010: Boris Schlenker; Kaspar Matiasek; Dieter Saur; Christian Gratzke; Ricarda M Bauer; Yared Herouy; Christian Arndt; Armin Blesch; Rudolf Hartung; Christian G Stief; Norbert Weidner; F May
Effects of cavernous nerve reconstruction on expression of nitric oxide synthase isoforms in rats.
BJU international 2010;106(11):1726-31.
2010: Günter Schneider; Oliver H Krämer; Petra Fritsche; Susanne Schüler; Roland M Schmid; Dieter Saur
Targeting histone deacetylases in pancreatic ductal adenocarcinoma.
Journal of cellular and molecular medicine 2010;14(6A):1255-63.
2010: Susanne Schüler; Petra Fritsche; Sandra Diersch; Alexander Arlt; Roland M Schmid; Dieter Saur; Günter Schneider
HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells.
Molecular cancer 2010;9():80.
2009: Carolin Schild; Matthias Wirth; Maximilian Reichert; Roland M Schmid; Dieter Saur; Günter Schneider
PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells.
Molecular carcinogenesis 2009;48(12):1149-58.
2009: Florian Nagl; Katrin Schönhofer; Barbara Seidler; Jörg Mages; Hans-Dieter Allescher; Roland M Schmid; Günter Schneider; Dieter Saur
Retinoic acid-induced nNOS expression depends on a novel PI3K/Akt/DAX1 pathway in human TGW-nu-I neuroblastoma cells.
American journal of physiology. Cell physiology 2009;297(5):C1146-56.
2009: Birgit Pfost; Christof Seidl; Michael Autenrieth; Dieter Saur; Frank Bruchertseifer; Alfred Morgenstern; Markus Schwaiger; Reingard Senekowitsch-Schmidtke
Intravesical alpha-radioimmunotherapy with 213Bi-anti-EGFR-mAb defeats human bladder carcinoma in xenografted nude mice.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(10):1700-8.
2009: P Fritsche; Barbara Seidler; S Schüler; Angelika Schnieke; M Göttlicher; Roland M Schmid; Dieter Saur; Günter Schneider
HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA.
Gut 2009;58(10):1399-409.
2009: E Rognoni; M Widmaier; Cornelia Haczek; Klaus Mantwill; R Holzmüller; Bernd Gansbacher; Andreas Kolk; T Schuster; Roland M Schmid; Dieter Saur; Alexander Kaszubiak; Hermann Lage; Per Sonne Holm
Adenovirus-based virotherapy enabled by cellular YB-1 expression in vitro and in vivo.
Cancer gene therapy 2009;16(10):753-63.
2009: Johannes von Burstin; Stefan Eser; Mariel C Paul; Barbara Seidler; Martina Brandl; Marlena Messer; Alexander von Werder; Annegret Schmidt; Jörg Mages; Philipp Pagel; Angelika Schnieke; Roland M Schmid; Günter Schneider; Dieter Saur
E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex.
Gastroenterology 2009;137(1):361-71, 371.e1-5.
2009: Rainer Hamacher; Sandra Diersch; Melanie Scheibel; Florian Eckel; Martina Mayr; Roland Rad; Monther Bajbouj; Roland M Schmid; Dieter Saur; Günter Schneider
Interleukin 1 beta gene promoter SNPs are associated with risk of pancreatic cancer.
Cytokine 2009;46(2):182-6.
2009: J Khasawneh; M D Schulz; A Walch; J Rozman; M Hrabe de Angelis; Martin Klingenspor; A Buck; Markus Schwaiger; Dieter Saur; Roland M Schmid; Günter Klöppel; B Sipos; Florian R Greten; Melek C Arkan
Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3354-9.
2008: Johannes von Burstin; Stefan Eser; Barbara Seidler; Alexander Meining; Monther Bajbouj; Jörg Mages; Roland Lang; Alexander J Kind; Angelika E Schnieke; Roland M Schmid; Günter Schneider; Dieter Saur
Highly sensitive detection of early-stage pancreatic cancer by multimodal near-infrared molecular imaging in living mice.
International journal of cancer. Journal international du cancer 2008;123(9):2138-47.
2008: Ulrich Mayr; Alexander von Werder; Barbara Seidler; Wolfgang Reindl; Monther Bajbouj; Roland M Schmid; Günter Schneider; Dieter Saur
RCAS-mediated retroviral gene delivery: a versatile tool for the study of gene function in a mouse model of pancreatic cancer.
Human gene therapy 2008;19(9):896-906.
2008: Barbara Seidler; Annegret Schmidt; Ulrich Mayr; Hassan Nakhai; Roland M Schmid; Günter Schneider; Dieter Saur
A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(29):10137-42.
2008: Günter Schneider; Rainer Hamacher; Stefan Eser; Helmut Friess; Roland M Schmid; Dieter Saur
Molecular biology of pancreatic cancer--new aspects and targets.
Anticancer research 2008;28(3A):1541-50.
2008: Rainer Hamacher; Roland M Schmid; Dieter Saur; Günter Schneider
Apoptotic pathways in pancreatic ductal adenocarcinoma.
Molecular cancer 2008;7():64.
2007: Alexander Meining; Dieter Saur; Monther Bajbouj; Valentin Becker; Eric Peltier; Heinz Höfler; Claus Hann von Weyhern; Roland M Schmid; Christian Prinz
In vivo histopathology for detection of gastrointestinal neoplasia with a portable, confocal miniprobe: an examiner blinded analysis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2007;5(11):1261-7.
2007: Rainer Hamacher; Dieter Saur; Ralph Fritsch; Maximilian Reichert; Roland M Schmid; Günter Schneider
Casein kinase II inhibition induces apoptosis in pancreatic cancer cells.
Oncology reports 2007;18(3):695-701.
2007: Ralph Fritsch; Günter Schneider; Dieter Saur; Melanie Scheibel; Roland M Schmid
Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation.
The Journal of biological chemistry 2007;282(31):22551-62.
2007: Birol Yüce; Andrei Sibaev; Andreas Haaken; Dieter Saur; Hans-Dieter Allescher; Burkhard Göke; Jean-Pierre Timmermans; Martin Storr
ORL-1 receptor mediates the action of nociceptin on ascending myenteric reflex pathways in rats.
Gastroenterology 2007;133(2):574-86.
2007: Günter Schneider; Maximilian Reichert; Dieter Saur; Rainer Hamacher; Ralph Fritsch; Roland M Schmid
HDAC3 is linked to cell cycle machinery in MiaPaCa2 cells by regulating transcription of skp2.
Cell proliferation 2007;40(4):522-31.
2007: Hana Algül; Matthias Treiber; Marina Lesina; Hassan Nakhai; Dieter Saur; Fabian Geisler; Alexander Pfeifer; Stephan Paxian; Roland M Schmid
Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis.
The Journal of clinical investigation 2007;117(6):1490-501.
2007: H Matthias Buchhorn; Christof Seidl; Roswitha Beck; Dieter Saur; Christos Apostolidis; Alfred Morgenstern; Markus Schwaiger; Reingard Senekowitsch-Schmidtke
Non-invasive visualisation of the development of peritoneal carcinomatosis and tumour regression after 213Bi-radioimmunotherapy using bioluminescence imaging.
European journal of nuclear medicine and molecular imaging 2007;34(6):841-9.
2007: Sebastian Kolb; Ralph Fritsch; Dieter Saur; Maximilian Reichert; Roland M Schmid; Günter Schneider
HMGA1 controls transcription of insulin receptor to regulate cyclin D1 translation in pancreatic cancer cells.
Cancer research 2007;67(10):4679-86.
2007: Maximilian Reichert; Dieter Saur; Rainer Hamacher; Roland M Schmid; Günter Schneider
Phosphoinositide-3-kinase signaling controls S-phase kinase-associated protein 2 transcription via E2F1 in pancreatic ductal adenocarcinoma cells.
Cancer research 2007;67(9):4149-56.
2006: Anar Dossumbekova; Christian Prinz; Jorg Mages; Roland Lang; Johannes G Kusters; Arnoud H M van Vliet; Wolfgang Reindl; Steffen Backert; Dieter Saur; Roland M Schmid; Roland Rad
Helicobacter pylori HopH (OipA) and bacterial pathogenicity: genetic and functional genomic analysis of hopH gene polymorphisms.
The Journal of infectious diseases 2006;194(10):1346-55.
2006: Günter Schneider; Dieter Saur; Jens T Siveke; Ralph Fritsch; Florian R Greten; Roland M Schmid
IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression.
The EMBO journal 2006;25(16):3801-12.
2006: Roland Rad; Lena Brenner; Stefan Bauer; Susanne Schwendy; Laura Layland; Clarissa Prazeres da Costa; Wolfgang Reindl; Anar Dossumbekova; Mathias Friedrich; Dieter Saur; Hermann Wagner; Roland M Schmid; Christian Prinz
CD25+/Foxp3+ T cells regulate gastric inflammation and Helicobacter pylori colonization in vivo.
Gastroenterology 2006;131(2):525-37.
2006: Wolfgang Huber; Florian Eckel; Michael Hennig; Hilkea Rosenbrock; Annette Wacker; Dieter Saur; Angelika Sennefelder; Romain Hennico; Cordula Schenk; Alexander Meining; Renate Schmelz; Ralph Fritsch; Wolfgang Weiss; Peter Hamar; Uwe Heemann; Roland M Schmid
Prophylaxis of contrast material-induced nephropathy in patients in intensive care: acetylcysteine, theophylline, or both? A randomized study.
Radiology 2006;239(3):793-804.
2005: Dieter Saur; Barbara Seidler; Günter Schneider; Hana Algül; Roswitha Beck; Reingard Senekowitsch-Schmidtke; Markus Schwaiger; Roland M Schmid
CXCR4 expression increases liver and lung metastasis in a mouse model of pancreatic cancer.
Gastroenterology 2005;129(4):1237-50.
2004: Roland Rad; Anar Dossumbekova; Bruno Neu; Roland Lang; S Bauer; Dieter Saur; Markus Gerhard; Christian Prinz
Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during Helicobacter pylori infection.
Gut 2004;53(8):1082-9.
2004: Ralph Fritsch; Dieter Saur; Manfred Kurjak; Daniela Oesterle; Jens Schlossmann; Angela Geiselhöringer; Franz Hofmann; Hans-Dieter Allescher
InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle.
The Journal of biological chemistry 2004;279(13):12551-9.
2004: Dieter Saur; Jean-Marie Vanderwinden; Barbara Seidler; Roland M Schmid; marc-Henri de laet; Hans-Dieter Allescher
Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(6):1662-7.
2002: Martin Storr; P Koppitz; Andrei Sibaev; Dieter Saur; Manfred Kurjak; Hartmut Franck; Volker Schusdziarra; Hans-Dieter Allescher
Melatonin reduces non-adrenergic, non-cholinergic relaxant neurotransmission by inhibition of nitric oxide synthase activity in the gastrointestinal tract of rodents in vitro.
Journal of pineal research 2002;33(2):101-8.
2002: Dieter Saur; Barbara Seidler; Heidi Paehge; Volker Schusdziarra; Hans-Dieter Allescher
Complex regulation of human neuronal nitric-oxide synthase exon 1c gene transcription. Essential role of Sp and ZNF family members of transcription factors.
The Journal of biological chemistry 2002;277(28):25798-814.
2002: Martin Storr; Andreas Hahn; Evelyn Gaffal; Dieter Saur; Hans-Dieter Allescher
Effects of endomorphin-1 and -2 on mu-opioid receptors in myenteric neurons and in the peristaltic reflex in rat small intestine.
Clinical and experimental pharmacology & physiology 2002;29(5-6):428-34.
2002: Dieter Saur; Winfried Neuhuber; Bernd Gengenbach; Andrea Huber; Volker Schusdziarra; Hans-Dieter Allescher
Site-specific gene expression of nNOS variants in distinct functional regions of rat gastrointestinal tract.
American journal of physiology. Gastrointestinal and liver physiology 2002;282(2):G349-58.
2002: Martin Storr; Evelyn Gaffal; Dieter Saur; Volker Schusdziarra; Hans-Dieter Allescher
Effect of cannabinoids on neural transmission in rat gastric fundus.
Canadian journal of physiology and pharmacology 2002;80(1):67-76.
2001: Manfred Kurjak; Ralph Fritsch; Dieter Saur; Volker Schusdziarra; Hans-Dieter Allescher
Functional coupling between nitric oxide synthesis and VIP release within enteric nerve terminals of the rat: involvement of protein kinase G and phosphodiesterase 5.
The Journal of physiology 2001;534(Pt 3):827-36.
2000: Martin Storr; Hartmut Franck; Dieter Saur; V Schusdziarra; Hans-Dieter Allescher
Mechanisms of alpha,beta-methylene atp-induced inhibition in rat ileal smooth muscle: involvement of intracellular Ca2+ stores in purinergic inhibition.
Clinical and experimental pharmacology & physiology 2000;27(10):771-9.
2000: Dieter Saur; H Paehge; Volker Schusdziarra; Hans-Dieter Allescher
Distinct expression of splice variants of neuronal nitric oxide synthase in the human gastrointestinal tract.
Gastroenterology 2000;118(5):849-58.
1999: Manfred Kurjak; Ralph Fritsch; Dieter Saur; Volker Schusdziarra; Hans-Dieter Allescher
NO releases bombesin-like immunoreactivity from enteric synaptosomes by cross-activation of protein kinase A.
The American journal of physiology 1999;276(6 Pt 1):G1521-30.
1998: Andrea Huber; Dieter Saur; Manfred Kurjak; Volker Schusdziarra; Hans-Dieter Allescher
Characterization and splice variants of neuronal nitric oxide synthase in rat small intestine.
The American journal of physiology 1998;275(5 Pt 1):G1146-56.