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Fredrik Björkling

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Mette Munk Jensen; Peter Buhl Jensen; Camilla Bardram Johnbeck; Fredrik Björkling; Kamille Dumong Erichsen; Liselotte Højgaard; Jacob Madsen; Maxwell Sehested; Andreas Kjaer
[18F]FDG and [18F]FLT positron emission tomography imaging following treatment with belinostat in human ovary cancer xenografts in mice.
Mette Munk Jensen; Jacob Madsen; Maxwell Sehested; Fredrik Björkling; Michael Bzorek; Kamille Dumong Erichsen; Liselotte Højgaard; Peter Buhl Jensen; Camilla Bardram Johnbeck; Andreas Kjaer
[18F]FLT and [18F]FDG PET for non-invasive treatment monitoring of the nicotinamide phosphoribosyltransferase inhibitor APO866 in human xenografts.
John M Kelly; Einars Loza; Martin C Taylor; David Horn; Ivars Kalvinsh; Fredrik Björkling
Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.

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All Publications

2013: Mette Munk Jensen; Peter Buhl Jensen; Camilla Bardram Johnbeck; Fredrik Björkling; Kamille Dumong Erichsen; Liselotte Højgaard; Jacob Madsen; Maxwell Sehested; Andreas Kjaer
[18F]FDG and [18F]FLT positron emission tomography imaging following treatment with belinostat in human ovary cancer xenografts in mice.
BMC cancer 2013;13():168.
2013: Mette Munk Jensen; Jacob Madsen; Maxwell Sehested; Fredrik Björkling; Michael Bzorek; Kamille Dumong Erichsen; Liselotte Højgaard; Peter Buhl Jensen; Camilla Bardram Johnbeck; Andreas Kjaer
[18F]FLT and [18F]FDG PET for non-invasive treatment monitoring of the nicotinamide phosphoribosyltransferase inhibitor APO866 in human xenografts.
PloS one 2013;8(1):e53410.
2012: John M Kelly; Einars Loza; Martin C Taylor; David Horn; Ivars Kalvinsh; Fredrik Björkling
Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.
Bioorganic & medicinal chemistry letters 2012;22(5):1886-90.
2012: Mette Munk Jensen; Maxwell Sehested; Jacob Madsen; Fredrik Björkling; Kamille Dumong Erichsen; Liselotte Højgaard; Peter Buhl Jensen; Andreas Kjaer
[18F]FLT PET for non-invasive assessment of tumor sensitivity to chemotherapy: studies with experimental chemotherapy TP202377 in human cancer xenografts in mice.
PloS one 2012;7(11):e50618.
2010: Mette K Christensen; Kamille D Erichsen; Christina Trojel-Hansen; Jette Tjørnelund; Søren J Nielsen; Karla Frydenvang; Tommy N Johansen; Birgitte Nielsen; Maxwell Sehested; Peter B Jensen; Martins Ikaunieks; Andrei Zaichenko; Einars Loza; Ivars Kalvinsh; Fredrik Björkling
Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones.
Journal of medicinal chemistry 2010;53(19):7140-5.
2010: Uffe H Olesen; Jakob G Petersen; Antje Garten; Wieland Kiess; Jun Yoshino; Shin-Ichiro Imai; Mette K Christensen; Peter Fristrup; Annemette Vinding Thougaard; Fredrik Björkling; Peter B Jensen; Søren J Nielsen; Maxwell Sehested
Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase.
BMC cancer 2010;10():677.
2010: Mette Munk Jensen; Kamille Dumong Erichsen; Fredrik Björkling; Jacob Madsen; Peter Buhl Jensen; Liselotte Højgaard; Maxwell Sehested; Andreas Kjaer
Early detection of response to experimental chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in human ovary cancer xenografts in mice.
PloS one 2010;5(9):e12965.
2009: Victor Andrianov; Vija Gailite; Daina Lola; Einars Loza; Valentina Semenikhina; Ivars Kalvinsh; Paul Finn; Kamille Dumong Petersen; James W A Ritchie; Nagma Khan; Anthony Tumber; Laura S Collins; Sree M Vadlamudi; Fredrik Björkling; Maxwell Sehested
Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.
European journal of medicinal chemistry 2009;44(3):1067-85.
2008: Uffe Høgh Olesen; Mette Knak Christensen; Fredrik Björkling; Marja Jäättelä; Peter Buhl Jensen; Maxwell Sehested; Søren Nielsen
Anticancer agent CHS-828 inhibits cellular synthesis of NAD.
Biochemical and biophysical research communications 2008;367(4):799-804.
2006: Stewart A Fyffe; Magnus S Alphey; Lori Buetow; Terry K Smith; Michael A J Ferguson; Morten Dahl Sørensen; Fredrik Björkling; William N Hunter
Recombinant human PPAR-beta/delta ligand-binding domain is locked in an activated conformation by endogenous fatty acids.
Journal of molecular biology 2006;356(4):1005-13.
2006: Stewart A Fyffe; Magnus S Alphey; Lori Buetow; Terry K Smith; Michael A J Ferguson; Morten Dahl Sørensen; Fredrik Björkling; William N Hunter
Reevaluation of the PPAR-beta/delta ligand binding domain model reveals why it exhibits the activated form.
Molecular cell 2006;21(1):1-2.
2005: Ernst Binderup; Fredrik Björkling; Pernille Vig Hjarnaa; Scilla Latini; Bodil Baltzer; Morten Carlsen; Lise Binderup
EB1627: a soluble prodrug of the potent anticancer cyanoguanidine CHS828.
Bioorganic & medicinal chemistry letters 2005;15(10):2491-4.
2004: Joachim Gullbo; Henrik Lövborg; Sumeer Dhar; Agneta Lukinius; Fredrik Oberg; Kenneth Nilsson; Fredrik Björkling; Lise Binderup; Peter Nygren; Rolf Larsson
Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguanidine CHS 828.
Anti-cancer drugs 2004;15(1):45-54.
2003: Erik Rytter Ottosen; Morten Dahl Sørensen; Fredrik Björkling; Tine Skak-Nielsen; Marianne Scheel Fjording; Helle Aaes; Lise Binderup
Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity.
Journal of medicinal chemistry 2003;46(26):5651-62.
2003: Berith F Jensen; Morten Dahl Sørensen; Anne-Marie Kissmeyer; Fredrik Björkling; Kim Sonne; Søren Balling Engelsen; Lars Nørgaard
Prediction of in vitro metabolic stability of calcitriol analogs by QSAR.
Journal of computer-aided molecular design 2003;17(12):849-59.
2003: Morten Dahl Sørensen; Lars K A Blaehr; Mette K Christensen; Thomas Høyer; Scilla Latini; Pernille-Julia V Hjarnaa; Fredrik Björkling
Cyclic phosphinamides and phosphonamides, novel series of potent matrix metalloproteinase inhibitors with antitumour activity.
Bioorganic & medicinal chemistry 2003;11(24):5461-84.
2003: Anne T Jørgensen; Morten Dahl Sørensen; Fredrik Björkling; Tommy Liljefors
Binding of alpha-hydroxy-beta-amino acid inhibitors to methionine aminopeptidase. The performance of two types of scoring functions.
Journal of computer-aided molecular design 2003;17(5-6):383-97.
2003: Lars K A Blaehr; Fredrik Björkling; Martin J Calverley; Ernst Binderup; Mikael Begtrup
Synthesis of novel hapten derivatives of 1alpha,25-dihydroxy-vitamin D3 and its 20-epi analogue.
The Journal of organic chemistry 2003;68(4):1367-75.
2002: Tore Duvold; Anne Jørgensen; Niels R Andersen; Anne S Henriksen; Morten Dahl Sørensen; Fredrik Björkling
17S,20S-Methanofusidic acid, a new potent semi-synthetic fusidane antibiotic.
Bioorganic & medicinal chemistry letters 2002;12(24):3569-72.
2001: Thomas A Bonasera; G Grue-Sørensen; Giuseppina Ortu; Ernst Binderup; Mats Bergström; Fredrik Björkling; Bengt Långström
The synthesis of [26,27-11C]dihydroxyvitamin D(3), a tracer for positron emission tomography (PET).
Bioorganic & medicinal chemistry 2001;9(12):3123-8.
2001: Tore Duvold; Morten Dahl Sørensen; Fredrik Björkling; A S Henriksen; N Rastrup-Andersen
Synthesis and conformational analysis of fusidic acid side chain derivatives in relation to antibacterial activity.
Journal of medicinal chemistry 2001;44(19):3125-31.
2001: Lars K A Blaehr; Fredrik Björkling; Ernst Binderup; Martin J Calverley; P Kaastrup
Polyclonal antibodies to EB1089 (seocalcitol), an analog of 1alpha,25-dihydroxyvitamin D(3)*.
Steroids 2001;66(7):539-48.
2001: AS Weiskopf; Paul Vouros; J Cunniff; Ernst Binderup; Fredrik Björkling; Lise Binderup; M C White; G H Posner
Examination of structurally selective derivatization of vitamin D(3) analogues by electrospray mass spectrometry.
Journal of mass spectrometry : JMS 2001;36(1):71-8.
2000: Sara Ekelund; G Liminga; Fredrik Björkling; E Ottosen; C Schou; Lise Binderup; Rolf Larsson
Early stimulation of acidification rate by novel cytotoxic pyridyl cyanoguanidines in human tumor cells: comparison with m-iodobenzylguanidine.
Biochemical pharmacology 2000;60(6):839-49.
2000: A Laghmich; Laurence Ladrière; H Dannacher; Fredrik Björkling; Willy J Malaisse
New esters of succinic acid and mixed molecules formed by such esters and a meglitinide analog: study of their insulinotropic potential.
Pharmacological research : the official journal of the Italian Pharmacological Society 2000;41(5):543-54.
2000: Willy J Malaisse; Laurence Ladrière; Ingrid Verbruggen; G Grue-Sørenson; Fredrik Björkling; Rudolph Willem
Metabolism of [1,3-13C]glycerol-1,2,3-tris(methylsuccinate) and glycerol-1,2,3-tris(methyl[2,3-13C]succinate) in rat hepatocytes.
Metabolism: clinical and experimental 2000;49(2):178-85.
1999: Laurence Ladrière; G Grue-Sørensen; Fredrik Björkling; Willy J Malaisse
Metabolism of glycerol-1,2,3-trimethylsuccinate in rat hepatocytes.
Molecular and cellular biochemistry 1999;198(1-2):135-9.
1999: Laurence Ladrière; Fredrik Björkling; Willy J Malaisse
Assessment of the nutritional value of glycerol-1,2, 3-tris(methylsuccinate) in fed and starved rats.
Molecular genetics and metabolism 1999;67(3):254-60.
1999: Laurence Ladriere; Ingrid Verbruggen; G Grue-Sørensen; Fredrik Björkling; Rudolph Willem; Willy J Malaisse
Metabolism of [1,3-(13)C]glycerol-1,2,3-tris(methylsuccinate) and glycerol-1,2,3-tris(methyl[2,3-(13)C]succinate) in hepatocytes from Goto-Kakizaki rats.
International journal of molecular medicine 1999;3(3):285-9.
1998: Marcus Quack; A Clarin; Ernst Binderup; Fredrik Björkling; Christina Mørk Hansen; Carsten Carlberg
Structural variants of the vitamin D analogue EB1089 reduce its ligand sensitivity and promoter selectivity.
Journal of cellular biochemistry 1998;71(3):340-50.
1998: Ida Stenfeldt Mathiasen; G Grue-Sørensen; Christina Mørk Hansen; Lise Binderup; Fredrik Björkling
Studies on the interaction between the vitamin D receptor and the radiolabelled 20-epi vitamin D analogue GS 1500.
Biochemical and biophysical research communications 1998;250(2):283-6.
1998: Laurence Ladrière; Dany Mercan; Fredrik Björkling; Willy J Malaisse
Improved viability and metabolic behavior of hepatocytes after liver storage in the presence of a succinic acid ester.
Transplantation 1998;66(2):183-5.
1998: A Laghmich; Laurence Ladrière; F Malaisse-Lagae; H Dannacher; Fredrik Björkling; Willy J Malaisse
Stimulation of biosynthetic activity by novel succinate esters in rat pancreatic islets.
Biochemical pharmacology 1998;55(6):909-13.
1998: Laurence Ladrière; A Laghmich; F Malaisse-Lagae; H Dannacher; Fredrik Björkling; Willy J Malaisse
Comparison between the insulinotropic potential of ten new esters of succinic acid.
European journal of pharmacology 1998;344(1):87-93.
1997: JA García-Martínez; María L Villanueva-Peñacarrillo; Isabel Valverde; Fredrik Björkling; WJ Malaisse
Stimulation of insulin release and potentiation of the insulinotropic action of antidiabetic agents by 1,2,3-tri(methylsuccinyl)glycerol ester in anaesthetized rats.
Pharmacological research : the official journal of the Italian Pharmacological Society 1997;36(5):369-72.
1997: Willy J Malaisse; Laurence Ladrière; A Laghmich; Louchami Karim; Hassan Jijakli; C Viñambres; María L Villanueva-Peñacarrillo; Isabel Valverde; Fredrik Björkling
Insulinotropic action of 1,2,3-Tri(methylsuccinyl)glycerol ester.
Biochemical and molecular medicine 1997;62(1):76-84.
1997: Willy J Malaisse; G Grue-Sørensen; Fredrik Björkling
Metabolism of glycerol-1,2,3-trimethylsuccinate in rat pancreatic islets.
Biochemical and biophysical research communications 1997;236(1):26-8.
1997: JA García-Martínez; María L Villanueva-Peñacarrillo; Isabel Valverde; Fredrik Björkling; WJ Malaisse
Potentiation of the insulinotropic and hypoglycemic action of gliquidone by succinic acid esters.
European journal of pharmacology 1997;325(1):65-8.
1997: JA García-Martínez; T M Zhang; María L Villanueva-Peñacarrillo; Isabel Valverde; Fredrik Björkling; WJ Malaisse
In vivo stimulation of insulin release by the monoethyl, monopropyl, monoisopropyl, monoallyl and diallyl esters of succinic acid.
Research communications in molecular pathology and pharmacology 1997;95(2):209-16.
1997: O Tvaermose-Nielsen; S Rachlin; H Dannacher; Fredrik Björkling; D Kirstein; Erik Bramm; C K Nielsen; J T Mortensen; Lise Binderup
Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist.
Bioorganic & medicinal chemistry 1997;5(2):415-27.
1995: T M Zhang; Fredrik Björkling; Willy J Malaisse
In vivo stimulation of insulin secretion by novel esters of succinic acid.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1995;27(5):251-2.
1994: Willy J Malaisse; T M Zhang; V Leclercq-Meyer; Abdullah Sener; Fredrik Björkling
Insulinotropic action of the D-glucosyl and 3-O-methyl-D-glucosyl monomethyl esters of succinic acid.
Diabetes research (Edinburgh, Scotland) 1994;25(3):93-105.