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Gianni Sava

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Marta Vadori; Francesca Vita; Sonia Zorzet; Moreno Cocchietto; Sabrina Pacor; Gianni Sava
Features and full reversibility of the renal toxicity of the ruthenium-based drug NAMI-A in mice.
Alberta Bergamo; Claudia Casarsa; Riccarda Delfino; Gianni Sava
CDK1 hyperphosphorylation maintenance drives the time-course of G2-M cell cycle arrest after short treatment with NAMI-A in Kb cells.
Gianni Sava; Elizabeth A Hillard; Gérard Jaouen; Alberta Bergamo
Targeted therapy vs. DNA-adduct formation-guided design: thoughts about the future of metal-based anticancer drugs.

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2013: Marta Vadori; Francesca Vita; Sonia Zorzet; Moreno Cocchietto; Sabrina Pacor; Gianni Sava
Features and full reversibility of the renal toxicity of the ruthenium-based drug NAMI-A in mice.
Journal of inorganic biochemistry 2013;118():21-7.
2012: Alberta Bergamo; Claudia Casarsa; Riccarda Delfino; Gianni Sava
CDK1 hyperphosphorylation maintenance drives the time-course of G2-M cell cycle arrest after short treatment with NAMI-A in Kb cells.
Anti-cancer agents in medicinal chemistry 2012;12(8):949-58.
2012: Gianni Sava; Elizabeth A Hillard; Gérard Jaouen; Alberta Bergamo
Targeted therapy vs. DNA-adduct formation-guided design: thoughts about the future of metal-based anticancer drugs.
Dalton transactions (Cambridge, England : 2003) 2012;41(27):8226-34.
2012: Alberta Bergamo; C Gaiddon; J H Beijnen; J H M Schellens; Gianni Sava
Approaching tumour therapy beyond platinum drugs: status of the art and perspectives of ruthenium drug candidates.
Journal of inorganic biochemistry 2012;106(1):90-9.
2011: Gianni Sava; Alberta Bergamo; Paul J Dyson
Metal-based antitumour drugs in the post-genomic era: what comes next?
Dalton transactions (Cambridge, England : 2003) 2011;40(36):9069-75.
2010: Teresa Gianferrara; Alberta Bergamo; Ioannis Bratsos; Barbara Milani; Cinzia Spagnul; Gianni Sava; Enzo Alessio
Ruthenium-porphyrin conjugates with cytotoxic and phototoxic antitumor activity.
Journal of medicinal chemistry 2010;53(12):4678-90.
2010: Alberta Bergamo; A Masi; A F A Peacock; A Habtemariam; P J Sadler; Gianni Sava
In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model.
Journal of inorganic biochemistry 2010;104(1):79-86.
2009: Alberta Bergamo; A Masi; M A Jakupec; B K Keppler; Gianni Sava
Inhibitory Effects of the Ruthenium Complex KP1019 in Models of Mammary Cancer Cell Migration and Invasion.
Metal-based drugs 2009;2009():681270.
2008: Alberta Bergamo; Alessia Masi; Paul J Dyson; Gianni Sava
Modulation of the metastatic progression of breast cancer with an organometallic ruthenium compound.
International journal of oncology 2008;33(6):1281-9.
2008: Moreno Cocchietto; Laura Zorzin; Paolo Alberto Veronesi; Gianni Sava
Oral poly(ethylene glycol)-conjugated human recombinant lysozyme control of lung metastases in mice.
Molecular medicine reports 2008;1(6):847-50.
2008: Cinzia Pellizzaro; Annalisa Speranza; Sonia Zorzet; Ilaria Crucil; Gianni Sava; Ignazio Scarlata; Silvia Cantoni; Maya Fedeli; Danila Coradini
Inhibition of human pancreatic cell line MIA PaCa2 proliferation by HA-But, a hyaluronic butyric ester: a preliminary report.
Pancreas 2008;36(4):e15-23.
2008: Ioannis Bratsos; Stephanie Jedner; Alberta Bergamo; Gianni Sava; Teresa Gianferrara; Ennio Zangrando; Enzo Alessio
Half-sandwich Ru II[9]aneS3 complexes structurally similar to antitumor-active organometallic piano-stool compounds: preparation, structural characterization and in vitro cytotoxic activity.
Journal of inorganic biochemistry 2008;102(5-6):1120-33.
2008: Darren Griffith; Sara Cecco; Ennio Zangrando; Alberto Bergamo; Gianni Sava; Celine J Marmion
Ruthenium(III) dimethyl sulfoxide pyridinehydroxamic acid complexes as potential antimetastatic agents: synthesis, characterisation and in vitro pharmacological evaluation.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2008;13(4):511-20.
2008: Ioannis Bratsos; Alberta Bergamo; Gianni Sava; Teresa Gianferrara; Ennio Zangrando; Enzo Alessio
Influence of the anionic ligands on the anticancer activity of Ru(II)-dmso complexes: Kinetics of aquation and in vitro cytotoxicity of new dicarboxylate compounds in comparison with their chloride precursors.
Journal of inorganic biochemistry 2008;102(4):606-17.
2007: Claudine Scolaro; Adrian B Chaplin; Christian G. Hartinger; Alberta Bergamo; Moreno Cocchietto; Bernhard K Keppler; Gianni Sava; Paul J Dyson
Tuning the hydrophobicity of ruthenium(II)-arene (RAPTA) drugs to modify uptake, biomolecular interactions and efficacy.
Dalton transactions (Cambridge, England : 2003) 2007;(43):5065-72.
2007: Carsten A Vock; Wee Han Ang; Claudine Scolaro; Andrew D Phillips; Lucienne Lagopoulos; Lucienne Juillerat-Jeanneret; Gianni Sava; Rosario Scopelliti; Paul J Dyson
Development of ruthenium antitumor drugs that overcome multidrug resistance mechanisms.
Journal of medicinal chemistry 2007;50(9):2166-75.
2007: Alberta Bergamo; Gianni Sava
Ruthenium complexes can target determinants of tumour malignancy.
Dalton transactions (Cambridge, England : 2003) 2007;(13):1267-72.
2007: Gianni Sava
Metal based drugs restyled and resumed.
Metal-based drugs 2007;2007():16260.
2006: Carsten A Vock; Claudine Scolaro; Andrew D Phillips; Rosario Scopelliti; Gianni Sava; Paul J Dyson
Synthesis, characterization, and in vitro evaluation of novel ruthenium(II) eta6-arene imidazole complexes.
Journal of medicinal chemistry 2006;49(18):5552-61.
2006: Isam Khalaila; Alberta Bergamo; Francois Bussy; Gianni Sava; Paul J Dyson
The role of cisplatin and NAMI-A plasma-protein interactions in relation to combination therapy.
International journal of oncology 2006;29(1):261-8.
2006: Danila Coradini; Cinzia Pellizzaro; Ignazio Scarlata; Sonia Zorzet; C Garrovo; Gabriella Abolafio; Annalisa Speranza; M Fedeli; Silvia Cantoni; Gianni Sava; Maria Grazia Daidone; Alberto Perbellini
A novel retinoic/butyric hyaluronan ester for the treatment of acute promyelocytic leukemia: preliminary preclinical results.
Leukemia 2006;20(5):785-92.
2006: Paul J Dyson; Gianni Sava
Metal-based antitumour drugs in the post genomic era.
Dalton transactions (Cambridge, England : 2003) 2006;(16):1929-33.
2006: Barbara Gava; Sonia Zorzet; Paola Spessotto; Moreno Cocchietto; Gianni Sava
Inhibition of B16 melanoma metastases with the ruthenium complex imidazolium trans-imidazoledimethylsulfoxide-tetrachlororuthenate and down-regulation of tumor cell invasion.
The Journal of pharmacology and experimental therapeutics 2006;317(1):284-91.
2005: Claudine Scolaro; Alberta Bergamo; Laura Brescacin; Riccarda Delfino; Moreno Cocchietto; Gábor Laurenczy; Tilmann J Geldbach; Gianni Sava; Paul J Dyson
In vitro and in vivo evaluation of ruthenium(II)-arene PTA complexes.
Journal of medicinal chemistry 2005;48(12):4161-71.
2005: Paride Papadia; Nicola Margiotta; Alberta Bergamo; Gianni Sava; Giovanni Natile
Platinum(II) complexes with antitumoral/antiviral aromatic heterocycles: effect of glutathione upon in vitro cell growth inhibition.
Journal of medicinal chemistry 2005;48(9):3364-71.
2005: Fabiana Frausin; Vito Scarcia; Moreno Cocchietto; Ariella Furlani; Barbara Serli; Enzo Alessio; Gianni Sava
Free exchange across cells, and echistatin-sensitive membrane target for the metastasis inhibitor NAMI-A (imidazolium trans-imidazole dimethyl sulfoxide tetrachlororuthenate) on KB tumor cells.
The Journal of pharmacology and experimental therapeutics 2005;313(1):227-33.
2004: Marina Bacac; Marta Vadori; Gianni Sava; Sabrina Pacor
Cocultures of metastatic and host immune cells: selective effects of NAMI-A for tumor cells.
Cancer immunology, immunotherapy : CII 2004;53(12):1101-10.
2004: Claudia Casarsa; Maria Teresa Mischis; Gianni Sava
TGFbeta1 regulation and collagen-release-independent connective tissue re-modelling by the ruthenium complex NAMI-A in solid tumours.
Journal of inorganic biochemistry 2004;98(10):1648-54.
2004: Nicola Margiotta; Alberta Bergamo; Gianni Sava; Giacomo Padovano; Erik De Clercq; Giovanni Natile
Antiviral properties and cytotoxic activity of platinum(II) complexes with 1,10-phenanthrolines and acyclovir or penciclovir.
Journal of inorganic biochemistry 2004;98(8):1385-90.
2004: Danila Coradini; Cinzia Pellizzaro; Gabriella Abolafio; Marco Bosco; Ignazio Scarlata; Silvia Cantoni; Luca Stucchi; Sonia Zorzet; Claudia Turrin; Gianni Sava; Alberto Perbellini; Maria Grazia Daidone
Hyaluronic-acid butyric esters as promising antineoplastic agents in human lung carcinoma: a preclinical study.
Investigational new drugs 2004;22(3):207-17.
2004: Sabrina Pacor; Sonia Zorzet; Moreno Cocchietto; Marina Bacac; Marta Vadori; Claudia Turrin; Barbara Gava; Anna Castellarin; Gianni Sava
Intratumoral NAMI-A treatment triggers metastasis reduction, which correlates to CD44 regulation and tumor infiltrating lymphocyte recruitment.
The Journal of pharmacology and experimental therapeutics 2004;310(2):737-44.
2004: Danila Coradini; Sonia Zorzet; Raffaella Rossin; Ignazio Scarlata; Cinzia Pellizzaro; Claudia Turrin; Michele Bello; Silvia Cantoni; Annalisa Speranza; Gianni Sava; Ulderico Mazzi; Alberto Perbellini
Inhibition of hepatocellular carcinomas in vitro and hepatic metastases in vivo in mice by the histone deacetylase inhibitor HA-But.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(14):4822-30.
2004: Gianni Sava; Fabiana Frausin; Moreno Cocchietto; Francesca Vita; Elena Podda; Paola Spessotto; Ariella Furlani; Vito Scarcia; Giuliano Zabucchi
Actin-dependent tumour cell adhesion after short-term exposure to the antimetastasis ruthenium complex NAMI-A.
European journal of cancer (Oxford, England : 1990) 2004;40(9):1383-96.
2004: Anna C G Hotze; Sabrine E Caspers; Dick de Vos; Huub Kooijman; Anthony L Spek; Anna Flamigni; Marina Bacac; Gianni Sava; Jaap G Haasnoot; Jan Reedijk
Structure-dependent in vitro cytotoxicity of the isomeric complexes [Ru(L)2Cl2] (L= o-tolylazopyridine and 4-methyl-2-phenylazopyridine) in comparison to [Ru(azpy)2Cl2].
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(3):354-64.
2004: Aldrik H Velders; Alberta Bergamo; Enzo Alessio; Ennio Zangrando; Jaap G Haasnoot; Claudia Casarsa; Moreno Cocchietto; Sonia Zorzet; Gianni Sava
Synthesis and chemical-pharmacological characterization of the antimetastatic NAMI-A-type Ru(III) complexes (Hdmtp)[trans-RuCl4(dmso-S)(dmtp)], (Na)[trans-RuCl4(dmso-S)(dmtp)], and [mer-RuCl3(H2O)(dmso-S)(dmtp)] (dmtp = 5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine).
Journal of medicinal chemistry 2004;47(5):1110-21.
2004: Marina Bacac; Anna C G Hotze; Karlijn van der Schilden; Jaap G Haasnoot; Sabrina Pacor; Enzo Alessio; Gianni Sava; Jan Reedijk
The hydrolysis of the anti-cancer ruthenium complex NAMI-A affects its DNA binding and antimetastatic activity: an NMR evaluation.
Journal of inorganic biochemistry 2004;98(2):402-12.
2004: Iztok Turel; Milena Pecanac; Amalija Golobic; Enzo Alessio; Barbara Serli; Alberta Bergamo; Gianni Sava
Solution, solid state and biological characterization of ruthenium(III)-DMSO complexes with purine base derivatives.
Journal of inorganic biochemistry 2004;98(2):393-401.
2004: Marisa Belicchi Ferrari; Franco Bisceglie; Giorgio Pelosi; Pieralberto Tarasconi; Roberto Albertini; Pier Paolo Dall'Aglio; Silvana Pinelli; Alberta Bergamo; Gianni Sava
Synthesis, characterization and biological activity of copper complexes with pyridoxal thiosemicarbazone derivatives. X-ray crystal structure of three dimeric complexes.
Journal of inorganic biochemistry 2004;98(2):301-12.
2004: Alberta Bergamo; Gabriele Stocco; Claudia Casarsa; Moreno Cocchietto; Enzo Alessio; Barbara Serli; Sonia Zorzet; Gianni Sava
Reduction of in vivo lung metastases by dinuclear ruthenium complexes is coupled to inhibition of in vitro tumour invasion.
International journal of oncology 2004;24(2):373-9.
2004: Enzo Alessio; Giovanni Mestroni; Alberta Bergamo; Gianni Sava
Ruthenium antimetastatic agents.
Current topics in medicinal chemistry 2004;4(15):1525-35.
2004: Enzo Alessio; Giovanni Mestroni; Alberta Bergamo; Gianni Sava
Ruthenium anticancer drugs.
Metal ions in biological systems 2004;42():323-51.
2003: Alberta Bergamo; Luigi Messori; Francesca Piccioli; Moreno Cocchietto; Gianni Sava
Biological role of adduct formation of the ruthenium(III) complex NAMI-A with serum albumin and serum transferrin.
Investigational new drugs 2003;21(4):401-11.
2003: Lucia Morbidelli; Sandra Donnini; Sandra Filippi; Luigi Messori; Francesca Piccioli; Pierluigi Orioli; Gianni Sava; Marina Ziche
Antiangiogenic properties of selected ruthenium(III) complexes that are nitric oxide scavengers.
British journal of cancer 2003;88(9):1484-91.
2003: Gianni Sava; Sonia Zorzet; Claudia Turrin; Francesca Vita; Maria Rosa Soranzo; Giuliano Zabucchi; Moreno Cocchietto; Alberta Bergamo; Stefano DiGiovine; Gabriella Pezzoni; Luigi Sartor; Spiridione Garbisa
Dual Action of NAMI-A in inhibition of solid tumor metastasis: selective targeting of metastatic cells and binding to collagen.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(5):1898-905.
2003: Luigi Messori; Giordana Marcon; Pierluigi Orioli; Marco Fontani; Piero Zanello; Alberta Bergamo; Gianni Sava; Pasquale Mura
Molecular structure, solution chemistry and biological properties of the novel [ImH][trans-IrCl(4)(Im)(DMSO)], (I) and of the orange form of [(DMSO)(2)H][trans-IrCl(4)(DMSO)(2)], (II), complexes.
Journal of inorganic biochemistry 2003;95(1):37-46.
2003: Alberta Bergamo; Gabriele Stocco; Barbara Gava; Moreno Cocchietto; Enzo Alessio; Barbara Serli; Elisabetta Iengo; Gianni Sava
Distinct effects of dinuclear ruthenium(III) complexes on cell proliferation and on cell cycle regulation in human and murine tumor cell lines.
The Journal of pharmacology and experimental therapeutics 2003;305(2):725-32.
2003: Marjan Bouma; Bastiaan Nuijen; Martine T Jansen; Gianni Sava; Fabrizio Picotti; Antonella Flaibani; Auke Bult; Jos H Beijnen
Development of a LC method for pharmaceutical quality control of the antimetastatic ruthenium complex NAMI-A.
Journal of pharmaceutical and biomedical analysis 2003;31(2):215-28.
2003: Moreno Cocchietto; Sonia Zorzet; Alenka Sorc; Gianni Sava
Primary tumor, lung and kidney retention and antimetastasis effect of NAMI-A following different routes of administration.
Investigational new drugs 2003;21(1):55-62.
2003: Dina N Akbayeva; Luca Gonsalvi; Werner Oberhauser; Maurizio Peruzzini; Francesco Vizza; Peter Brüggeller; Antonio Romerosa; Gianni Sava; Alberta Bergamo
Synthesis, catalytic properties and biological activity of new water soluble ruthenium cyclopentadienyl PTA complexes [(C5R5)RuCl(PTA)2] (R = H, Me; PTA = 1,3,5-triaza-7-phosphaadamantane).
Chemical communications (Cambridge, England) 2003;(2):264-5.
2002: Alberta Bergamo; Barbara Gava; Enzo Alessio; Giovanni Mestroni; Barbara Serli; Moreno Cocchietto; Sonia Zorzet; Gianni Sava
Ruthenium-based NAMI-A type complexes with in vivo selective metastasis reduction and in vitro invasion inhibition unrelated to cell cytotoxicity.
International journal of oncology 2002;21(6):1331-8.
2002: Marjan Bouma; Bastiaan Nuijen; Martine T Jansen; Gianni Sava; Auke Bult; Jos H Beijnen
Photostability profiles of the experimental antimetastatic ruthenium complex NAMI-A.
Journal of pharmaceutical and biomedical analysis 2002;30(4):1287-96.
2002: Marjan Bouma; Bastiaan Nuijen; Gianni Sava; Alberto Perbellini; Antonella Flaibani; Mies J van Steenbergen; Herre Talsma; J Jantina Kettenes-van den Bosch; Auke Bult; Jos H Beijnen
Pharmaceutical development of a parenteral lyophilized formulation of the antimetastatic ruthenium complex NAMI-A.
International journal of pharmaceutics 2002;248(1-2):247-59.
2002: Marjan Bouma; Bastiaan Nuijen; Martine T Jansen; Gianni Sava; Antonella Flaibani; Auke Bult; Jos H Beijnen
A kinetic study of the chemical stability of the antimetastatic ruthenium complex NAMI-A.
International journal of pharmaceutics 2002;248(1-2):239-46.
2002: Fabiana Frausin; Moreno Cocchietto; Alberta Bergamo; Vito Scarcia; Ariella Furlani; Gianni Sava
Tumour cell uptake of the metastasis inhibitor ruthenium complex NAMI-A and its in vitro effects on KB cells.
Cancer chemotherapy and pharmacology 2002;50(5):405-11.
2002: Sabrina Pacor; Anna Giangaspero; Marina Bacac; Gianni Sava; Alessandro Tossi
Analysis of the cytotoxicity of synthetic antimicrobial peptides on mouse leucocytes: implications for systemic use.
The Journal of antimicrobial chemotherapy 2002;50(3):339-48.
2002: Moreno Cocchietto; skert nicola; Pier Luigi Nimis; Gianni Sava
A review on usnic acid, an interesting natural compound.
Die Naturwissenschaften 2002;89(4):137-46.
2002: Angelo Vacca; M Bruno; Angelina Boccarelli; Mauro Coluccia; Dragana Vukasovic; Alberta Bergamo; Spiridione Garbisa; Luigi Sartor; Gianni Sava
Inhibition of endothelial cell functions and of angiogenesis by the metastasis inhibitor NAMI-A.
British journal of cancer 2002;86(6):993-8.
2002: Gianni Sava; Alberta Bergamo; Sonia Zorzet; Barbara Gava; Claudia Casarsa; Moreno Cocchietto; Ariella Furlani; Vito Scarcia; Barbara Serli; Elisabetta Iengo; Enzo Alessio; Giovanni Mestroni
Influence of chemical stability on the activity of the antimetastasis ruthenium compound NAMI-A.
European journal of cancer (Oxford, England : 1990) 2002;38(3):427-35.
2001: Sabrina Pacor; Marta Vadori; Francesca Vita; Marina Bacac; Maria Rosa Soranzo; Giuliano Zabucchi; Gianni Sava
Isolation of a murine metastatic cell line and preliminary test of sensitivity to the anti-metastasis agent NAMI-A.
Anticancer research 2001;21(4A):2523-30.
2001: Alberta Bergamo; Sonia Zorzet; Moreno Cocchietto; ME Carotenuto; Monica Magnarin; Gianni Sava
Tumour cell uptake G2-M accumulation and cytotoxicity of NAMI-A on TS/A adenocarcinoma cells.
Anticancer research 2001;21(3B):1893-8.
2001: Sonia Zorzet; A Sorc; Claudia Casarsa; Moreno Cocchietto; Gianni Sava
Pharmacological Effects of the Ruthenium Complex NAMI-A Given Orally to CBA Mice With MCa Mammary Carcinoma.
Metal-based drugs 2001;8(1):1-7.
2000: Sonia Zorzet; Alberta Bergamo; Moreno Cocchietto; Alenka Sorc; Barbara Gava; Enzo Alessio; Elisabetta Iengo; Gianni Sava
Lack of In vitro cytotoxicity, associated to increased G(2)-M cell fraction and inhibition of matrigel invasion, may predict In vivo-selective antimetastasis activity of ruthenium complexes.
The Journal of pharmacology and experimental therapeutics 2000;295(3):927-33.
2000: Gianni Sava; Moreno Cocchietto
Blood levels of ruthenium following repeated treatments with the antimetastatic compound NAMI-A in healthy beagle dogs.
In vivo (Athens, Greece) 2000;14(6):741-4.
2000: Moreno Cocchietto; Gianni Sava
Blood concentration and toxicity of the antimetastasis agent NAMI-A following repeated intravenous treatment in mice.
Pharmacology & toxicology 2000;87(5):193-7.
2000: Alberta Bergamo; Sonia Zorzet; Barbara Gava; Alenka Sorc; Enzo Alessio; Elisabetta Iengo; Gianni Sava
Effects of NAMI-A and some related ruthenium complexes on cell viability after short exposure of tumor cells.
Anti-cancer drugs 2000;11(8):665-72.
2000: Monica Magnarin; Alberta Bergamo; ME Carotenuto; Sonia Zorzet; Gianni Sava
Increase of tumour infiltrating lymphocytes in mice treated with antimetastatic doses of NAMI-A.
Anticancer research 2000;20(5A):2939-44.
2000: Gianni Sava; Alberta Bergamo
Ruthenium-based compounds and tumour growth control (review).
International journal of oncology 2000;17(2):353-65.
2000: Enzo Alessio; Elisabetta Iengo; Sonia Zorzet; Alberta Bergamo; Mauro Coluccia; Angelina Boccarelli; Gianni Sava
Antimetastatic properties and DNA interactions of the novel class of dimeric Ru(III) compounds Na2[[trans-RuCl4(Me2SO)]2(mu-L)] (L = ditopic, non-chelating aromatic N-ligand). A preliminary investigation.
Journal of inorganic biochemistry 2000;79(1-4):173-7.
2000: Moreno Cocchietto; G Salerno; Enzo Alessio; Giovanni Mestroni; Gianni Sava
Fate of the antimetastatic ruthenium complex ImH [trans-RuCl4(DMSO)Im] after acute i.v. treatment in mice.
Anticancer research 2000;20(1A):197-202.
2000: Sabrina Pacor; Monica Magnarin; ME Carotenuto; Paola Spessotto; Giuliano Zabucchi; Gianni Sava
In vitro growth of TS/A adenocarcinoma and of the gene transfected TS/A-IL4 line on biological substrates.
Anticancer research 2000;20(1A):191-6.
1999: Sabrina Pacor; R Gagliardi; E Di Daniel; Marta Vadori; Gianni Sava
In vitro down regulation of ICAM-1 and E-cadherin and in vivo reduction of lung metastases of TS/A adenocarcinoma by a lysozyme derivative.
International journal of molecular medicine 1999;4(4):369-75.
1999: Alberta Bergamo; R Gagliardi; Vito Scarcia; Ariella Furlani; Enzo Alessio; Giovanni Mestroni; Gianni Sava
In vitro cell cycle arrest, in vivo action on solid metastasizing tumors, and host toxicity of the antimetastatic drug NAMI-A and cisplatin.
The Journal of pharmacology and experimental therapeutics 1999;289(1):559-64.
1999: Gianni Sava; Alberta Bergamo
Drug control of solid tumour metastases: a critical view.
Anticancer research 1999;19(2A):1117-24.
1999: Gianni Sava; R Gagliardi; Alberta Bergamo; Enzo Alessio; Giovanni Mestroni
Treatment of metastases of solid mouse tumours by NAMI-A: comparison with cisplatin, cyclophosphamide and dacarbazine.
Anticancer research 1999;19(2A):969-72.
1999: Sabrina Pacor; R Gagliardi; Paola Spessotto; Giuliano Zabucchi; Gianni Sava
Paracrine effects of IL-4 transfection on TS/A adenocarcinoma cells mediate reduced in vivo growth.
Pathology oncology research : POR 1999;5(2):110-6.
1999: Gianni Sava; K Clerici; I Capozzi; Moreno Cocchietto; R Gagliardi; Enzo Alessio; Giovanni Mestroni; Alberto Perbellini
Reduction of lung metastasis by ImH[trans-RuCl4(DMSO)Im]: mechanism of the selective action investigated on mouse tumors.
Anti-cancer drugs 1999;10(1):129-38.
1998: I Capozzi; K Clerici; Moreno Cocchietto; G Salerno; Alberta Bergamo; Gianni Sava
Modification of cell cycle and viability of TLX5 lymphoma in vitro by sulfoxide-ruthenium compounds and cisplatin detected by flow cytometry.
Chemico-biological interactions 1998;113(1):51-64.
1998: Gianni Sava; I Capozzi; K Clerici; G Gagliardi; Enzo Alessio; Giovanni Mestroni
Pharmacological control of lung metastases of solid tumours by a novel ruthenium complex.
Clinical & experimental metastasis 1998;16(4):371-9.
1998: Gianni Sava; R Gagliardi; Moreno Cocchietto; K Clerici; I Capozzi; M Marrella; Enzo Alessio; Giovanni Mestroni; R Milanino
Comparison of the effects of the antimetastatic compound ImH[trans-RuCl4(DMSO)Im] (NAMI-A) on the arthritic rat and on MCa mammary carcinoma in mice.
Pathology oncology research : POR 1998;4(1):30-6.
1996: Gianni Sava; Alberta Bergamo; I Capozzi; K Clerici; Sabrina Pacor; R Gagliardi; E Giacomello; M Zacchigna; G Di Luca; E Boccu
Stimulation of GALT and activation of mesenteric lymph node lymphocytes by a modified lysozyme in CBA mice with MCa mammary carcinoma.
Journal of experimental therapeutics & oncology 1996;1(6):342-9.
1996: Gianni Sava; I Capozzi; Alberta Bergamo; R Gagliardi; Moreno Cocchietto; L Masiero; Maurizio Onisto; Enzo Alessio; Giovanni Mestroni; Spiridione Garbisa
Down-regulation of tumour gelatinase/inhibitor balance and preservation of tumour endothelium by an anti-metastatic ruthenium complex.
International journal of cancer. Journal international du cancer 1996;68(1):60-6.
1996: Sabrina Pacor; E Giacomello; Alberta Bergamo; K Clerici; M Zacchigna; E Boccu; Gianni Sava
Antimetastatic action and lymphocyte activation by the modified lysozyme mPEG-Lyso in mice with MCa mammary carcinoma.
Anticancer research 1996;16(5A):2559-64.
1996: Alberta Bergamo; Moreno Cocchietto; I Capozzi; Giovanni Mestroni; Enzo Alessio; Gianni Sava
Treatment of residual metastases with Na[trans-RuCl4 (DMSO)lm] and ruthenium uptake by tumor cells.
Anti-cancer drugs 1996;7(6):697-702.
1996: Sabrina Pacor; E Giacomello; Alberta Bergamo; R Gagliardi; Moreno Cocchietto; Gianni Sava
Cytofluorimetric analysis of gut-intraepithelial and mesenteric lymph node lymphocytes of tumour bearing mice fed with egg-white lysozyme.
Anticancer research 1996;16(1):145-9.
1995: Gianni Sava; Sabrina Pacor; G Dasić; Alberta Bergamo
Lysozyme stimulates lymphocyte response to ConA and IL-2 and potentiates 5-fluorouracil action on advanced carcinomas.
Anticancer research 1995;15(5B):1883-8.
1995: Gianni Sava; Sabrina Pacor; Alberta Bergamo; Moreno Cocchietto; Giovanni Mestroni; Enzo Alessio
Effects of ruthenium complexes on experimental tumors: irrelevance of cytotoxicity for metastasis inhibition.
Chemico-biological interactions 1995;95(1-2):109-26.
1994: R Gagliardi; Gianni Sava; Sabrina Pacor; Giovanni Mestroni; Enzo Alessio
Antimetastatic action and toxicity on healthy tissues of Na[trans-RuCl4(DMSO)Im] in the mouse.
Clinical & experimental metastasis 1994;12(2):93-100.
1993: F Bregant; Sabrina Pacor; S Ghosh; S K Chattopadhyay; Gianni Sava
Effects of some ruthenium chelates on MCa mammary carcinoma and on TLX5 lymphoma in mice.
Anticancer research 1993;13(4):1011-7.
1993: Mauro Coluccia; Gianni Sava; F Loseto; A Nassi; Angelina Boccarelli; Domenico Giordano; Enzo Alessio; Giovanni Mestroni
Anti-leukaemic action of RuCl2 (DMSO)4 isomers and prevention of brain involvement on P388 leukaemia and on P388/DDP subline.
European journal of cancer (Oxford, England : 1990) 1993;29A(13):1873-9.
1992: Gianni Sava; Sabrina Pacor; Giovanni Mestroni; Enzo Alessio
Na[trans-RuCl4(DMSO)Im], a metal complex of ruthenium with antimetastatic properties.
Clinical & experimental metastasis 1992;10(4):273-80.
1992: Gianni Sava; Sabrina Pacor; Giovanni Mestroni; Enzo Alessio
Effects of the Ru(III) complexes [mer-RuCl3(DMSO)2Im]degrees and Na[trans-RuCl4(DMSO)Im] on solid mouse tumors.
Anti-cancer drugs 1992;3(1):25-31.
1992: Sabrina Pacor; Gianni Sava; Giovanni Mestroni; Enzo Alessio
Tumor inhibition and effects on host survival time by rutheniumIII and rhodiumIII complexes with dimethylsulphoxide ligands.
Pharmacological research : the official journal of the Italian Pharmacological Society 1992;25 Suppl 1():73-4.
1991: A Varnavas; C Nisi; L Lassiani; Gianni Sava; Laura Perissin; E Boccù
Synthesis and antitumor activity of hydrosoluble analogs of p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt.
Arzneimittel-Forschung 1991;41(11):1168-72.
1991: Gianni Sava; V Ceschia; Sabrina Pacor; Giuliano Zabucchi
Observations on the antimetastatic action of lysozyme in mice bearing Lewis lung carcinoma.
Anticancer research 1991;11(3):1109-13.
1991: Gianni Sava; Sabrina Pacor; F Bregant; V Ceschia
Metal complexes of ruthenium: a potential class of selective anticancer drugs.
Anticancer research 1991;11(3):1103-7.
1991: Sabrina Pacor; Gianni Sava; V Ceschia; F Bregant; Giovanni Mestroni; Enzo Alessio
Antineoplastic effect of mer-trichlorobisdimethylsulphoxideaminorutheniumIII against murine tumors: comparison with cisplatin and with ImH[RuIm2Cl4].
Chemico-biological interactions 1991;78(2):223-34.
1991: Gianni Sava; Sonia Zorzet; Laura Perissin; Sabrina Pacor; L Lassiani; C Nisi; A Varnavas
Antineoplastic action of p-(3-methyl-1-triazeno)benzoic acid potassium salt, a monomethyl derivative of the antimetastatic compound DM-COOK.
Cancer chemotherapy and pharmacology 1991;27(6):423-8.
1990: Gianni Sava; Sabrina Pacor; F Bregant; V Ceschia; Giovanni Mestroni
Metal complexes of ruthenium: antineoplastic properties and perspectives.
Anti-cancer drugs 1990;1(2):99-108.
1990: L Lassiani; C Ebert; C Nisi; A Varnavas; Sonia Zorzet; Gianni Sava; E Boccù
Kinetic investigation of the aqueous stability and antitumor activity of a hydrosoluble diaryltriazene, AVIS, related to the antimetastatic agent DM-COOK.
Die Pharmazie 1990;45(10):743-5.
1990: F Bregant; V Ceschia; Sabrina Pacor; Gianni Sava
Reduction of MCa mammary carcinoma in mice fed with egg-white lysozyme.
Pharmacological research : the official journal of the Italian Pharmacological Society 1990;22 Suppl 3():95-6.
1989: Sabrina Pacor; E Luxich; V Ceschia; Gianni Sava; Enzo Alessio; Giovanni Mestroni
Effects of trans-RuCl2 (DMSO)4 on B16 melanoma in mice.
Pharmacological research : the official journal of the Italian Pharmacological Society 1989;21 Suppl 1():127-8.
1989: Gianni Sava; V Ceschia; Sabrina Pacor; Sonia Zorzet; Laura Perissin
Antineoplastic action of egg-white lysozyme on the growth of MCa mammary carcinoma and TLX5 lymphoma in the CBA mouse.
Methods and findings in experimental and clinical pharmacology 1989;11(11):683-9.
1989: Gianni Sava; Laura Perissin; Sonia Zorzet; P Piccini; Tullio Giraldi
Antimetastatic action of the prostacyclin analog iloprost in the mouse.
Clinical & experimental metastasis 1989;7(6):671-8.
1989: Gianni Sava; Sabrina Pacor; Sonia Zorzet; Enzo Alessio; Giovanni Mestroni
Antitumour properties of dimethylsulphoxide ruthenium (II) complexes in the Lewis lung carcinoma system.
Pharmacological research : the official journal of the Italian Pharmacological Society 1989;21(5):617-28.
1989: Gianni Sava; V Ceschia; Sabrina Pacor
Mechanism of the antineoplastic action of lysozyme: evidence for host mediated effects.
Anticancer research 1989;9(4):1175-80.
1989: Gianni Sava; Sabrina Pacor; V Ceschia; G Zassinovich; Giovanni Mestroni
Antitumor effect of some rhodium(I) derivatives on MCa mammary carcinoma.
Anticancer research 1989;9(3):787-90.
1989: Gianni Sava; Sabrina Pacor; V Ceschia; G Zassinovich; Giovanni Mestroni
Inhibition of carrageenin paw edema by pyridinalalkylimine rhodium(I) complexes.
Anticancer research 1989;9(3):767-70.
1989: Gianni Sava; A Benetti; V Ceschia; Sabrina Pacor
Lysozyme and cancer: role of exogenous lysozyme as anticancer agent (review).
Anticancer research 1989;9(3):583-91.
1989: Gianni Sava; Sonia Zorzet; Sabrina Pacor; Giovanni Mestroni; G Zassinovich
Effects of two pyridinalalkyliminerhodium(I) complexes in mice bearing MCa mammary carcinoma.
Cancer chemotherapy and pharmacology 1989;24(5):302-6.
1989: Gianni Sava
Reduction of B16 melanoma metastases by oral administration of egg-white lysozyme.
Cancer chemotherapy and pharmacology 1989;25(3):221-2.
1988: Gianni Sava; V Ceschia; Giuliano Zabucchi
Evidence for host-mediated antitumor effects of lysozyme in mice bearing the MCa mammary carcinoma.
European journal of cancer & clinical oncology 1988;24(11):1737-43.
1988: V Ceschia; Gianni Sava; R Gagliardi; Giuliano Zabucchi
Effects of lysozyme on spleen and lungs in mice with Lewis lung carcinoma.
Pharmacological research communications 1988;20(7):615-6.
1988: Gianni Sava; Laura Perissin; Sonia Zorzet
Antimetastatic action of orally administered lysozyme in mice bearing Lewis lung carcinoma.
Clinical & experimental metastasis 1988;6(3):245-53.
1988: Gianni Sava; Sonia Zorzet; Laura Perissin; Tullio Giraldi; L Lassiani
Effects of an inducer and an inhibitor of hepatic metabolism on the antitumor action of dimethyltriazenes.
Cancer chemotherapy and pharmacology 1988;21(3):241-5.
1988: Tullio Giraldi; Gianni Sava; Laura Perissin; Sonia Zorzet
Role of host responses in the drug treatment of metastasis.
Advances in experimental medicine and biology 1988;233():351-60.
1987: Tullio Giraldi; Gianni Sava; Sonia Zorzet; Laura Perissin; P Piccini
Activity and inhibition by cytotoxic and antimetastatic drugs of cathepsin B-like cysteine proteinase in transplantable leukemias in mice.
Anticancer research 1987;7(3 Pt B):343-6.
1987: Gianni Sava; P Piccini; Giovanni Mestroni; G Zassinovich; A Bontempi
Inhibitory effects of some organometallic complexes of rhodium(I) and iridium(I) on carrageenin paw edema in rats.
In vivo (Athens, Greece) 1987;1(1):27-30.
1985: Gianni Sava; Sonia Zorzet; Laura Perissin; L Lassiani; J Tomasic
Effects of postsurgical immunotherapy with PGM in mice bearing Lewis lung carcinoma treated with p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt.
Methods and findings in experimental and clinical pharmacology 1985;7(9):477-80.
1985: Gianni Sava; Sonia Zorzet; Giovanni Mestroni; G Zassinovich
Antineoplastic activity of planar rhodium(I) complexes in mice bearing Lewis lung carcinoma and P388 leukemia.
Anticancer research 1985;5(3):249-52.
1985: Gianni Sava; Laura Perissin; L Lassiani; G Zabucchi
Antiinflammatory action of hydrosoluble dimethyltriazenes on the carrageenin-induced edema in guinea pigs.
Chemico-biological interactions 1985;53(1-2):37-43.
1984: Gianni Sava; Sonia Zorzet; Tullio Giraldi; Giovanni Mestroni; G Zassinovich
Antineoplastic activity and toxicity of an organometallic complex of ruthenium(II) in comparison with cis-PDD in mice bearing solid malignant neoplasms.
European journal of cancer & clinical oncology 1984;20(6):841-7.
1984: Gianni Sava; Tullio Giraldi; L Lassiani; C Nisi
Antimetastatic action and hematological toxicity of p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt and 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide used as prophylactic adjuvants to surgical tumor removal in mice bearing B16 melanoma.
Cancer research 1984;44(1):64-8.
1984: B Nardelli; Paolo Puccetti; Luigina Romani; Gianni Sava; E Bonmassar; Maria C Fioretti
Chemical xenogenization of murine lymphoma cells with triazene derivatives: immunotoxicological studies.
Cancer immunology, immunotherapy : CII 1984;17(3):213-7.
1984: B Nardelli; A R Contessa; Luigina Romani; Gianni Sava; C Nisi; Maria C Fioretti
Immunogenic changes of murine lymphoma cells following in vitro treatment with aryl-triazene derivatives.
Cancer immunology, immunotherapy : CII 1984;16(3):157-61.
1983: Gianni Sava; Tullio Giraldi; L Lassiani; R Dogani
Effects of isomeric aryldimethyltriazenes on Lewis lung carcinoma growth and metastases in mice.
Chemico-biological interactions 1983;46(1):131-6.
1983: Gianni Sava; Tullio Giraldi; Giovanni Mestroni; G Zassinovich
Antitumor effects of rhodium(I), iridium(I) and ruthenium(II) complexes in comparison with cis-dichlorodiammino platinum(II) in mice bearing Lewis lung carcinoma.
Chemico-biological interactions 1983;45(1):1-6.
1982: Gianni Sava; Tullio Giraldi; L Lassiani; C Nisi; P B Farmer
Mechanism of the antileukemic effects of 1-p-carboxamidophenyl-3,3-dimethyltriazene and its in vitro metabolites.
Biochemical pharmacology 1982;31(22):3629-34.
1982: Gianni Sava; Tullio Giraldi; L Lassiani; C Nisi
Metabolism and mechanism of the antileukemic action of isomeric aryldimethyltriazenes.
Cancer treatment reports 1982;66(9):1751-5.
1982: Gianni Sava; Tullio Giraldi; C Nisi; G Bertoli
Prophylactic antimetastatic treatment with aryldimethyltriazenes as adjuvants to surgical tumor removal in mice bearing Lewis lung carcinoma.
Cancer treatment reports 1982;66(1):115-20.
1981: Tullio Giraldi; Gianni Sava; R Cuman; C Nisi; L Lassiani
Selectivity of the antimetastatic and cytotoxic effects of 1-p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt (+/-)-1,2-di(3,5-dioxopiperazin-1-yl)propane, and cyclophosphamide in mice bearing Lewis lung carcinoma.
Cancer research 1981;41(6):2524-8.
1980: L Lassiani; C Nisi; F Sigon; Gianni Sava; Tullio Giraldi
Synthesis of 1-aryl-3-formyl-3-methyltriazenes, potential metabolites of 1-aryl-3,3-dimethyltriazenes.
Journal of pharmaceutical sciences 1980;69(9):1098-9.
1980: Tullio Giraldi; A M Guarino; C Nisi; Gianni Sava
Antitumor and antimetastatic effects of benzenoid triazenes in mice bearing Lewis lung carcinoma.
Pharmacological research communications 1980;12(1):1-11.